TIROID HORMONE AND ANTITIROID

TIROID GLAND

SYNTHESIS

DIT

MIT

DIT

MIT

T3

T4

H2O2

C

I-

I-

A

I+

HOI

ATAU

EOI

H2O2 LUMEN

INTRA CEL

ECF

Membran Basalis

D

B

MIT

DIT

T4

T3 T3

E F

G

Keterangan:

A: Transport of I-

B: Iodination

C: MIT and DIT

formation

D: Coloid

Resorption

E: Proteolysis

F: Deiodination of

MIT dan DIT

G: Deiodination of

T4

I-

SINTESA HORMON TIROID

1. PENGAMBILAN I

2. OKSIDASI DAN IODINASI

3. PEMBENTUKAN T4 DAN T3 DARI

IODOTIROSIN

4. SEKRESI HORMON TIROID

5. PRUBAHAN T4 MENJADI T3 DI

PERIVER

STRUCTURE

TRANSPORT

TBG (T3 DAN T4)

TRANSTIRETIN (T4)

PROTECTION, METABOLISM AND EXCRETION

FREE

0.03% T4 &

0.3% T3

BINDING

Metadon

Esterogene

Clofibrate

Heroine

Tamoksiphen

BINDING

Glucocorticoid

Androgen

Salicylate

Mefenamic acid

Furocemide

LIVER

HIV

ACUT AND

CHRONIS

DISEASES

MECHANISM of ACTION

DNA BINDING

SITES LIGAND BINDING SITES

TRb2

TRb1

TRa1

c-erbAa2

TRa1 dan TRb1 APPEAR IN TH RESPONSIVE TISSUES

TRb2: anterior Pituitary

c-erb A a2 : cerebral

PHARMACOLOGICAL EFFECTS

SECRETION DISTURBANCES

PREPARATES

Tiroksin (levotiroksin Na= L-T4)

Liotironin Na ( L-T3)

ANTITIROID

Proses dihambat Contoh

Transport I- Perchlorat, fluoborat, SCN

Iodinasi tiroglobulin Thionamid, PTU, Mtimazol

Reaksi Coupling Thionamid, Sulfonamid

Pelepasan Hormon Garam Li, Iodida

Deiodinasi iodotirosin Nitrotirosin

Deiodinasi periver Der. TU, Amiodaron

EFEK SAMPING ANTITIROID

Perchlorat, : Anemia aplastis

PTU, Mtimazol : agaranulositosis (-), urticaria

Iodida : radang tenggorokan, endarahan

kulit, hipersensitif, eosinofilia,

trombositopenia

RAIod : hipotiroidism tertunda

Untuk : hipertiroid (dws) dan Graves’s Disease, Ca

Tiroid metastase

CI : hamil

SINTESA HORMON TIROID