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Index
Aβ see amyloid-βABILHAND questionnaire 591abundance, in motor system
602–5acarbose 424accelerometers, triaxial 66–7accidental injuries, wheelchair
users 162ACE (angiotensin-converting
enzyme) genotype 538acetyl L-carnitine 641acetylcholine (ACh) 415, 417activity-dependent learning
132inhibitors see anticholinergic
drugsacetylcholine receptors (AChRs)
2, 317, 415acetylcholinesterase (AChE)
inhibitors 479–80cognitive rehabilitation with
522traumatic brain injury
480, 541acetylsalicylic acid (ASA, aspirin)
601–2acquired brain injury (ABI),
virtual realityapplications 203–4, 207
ACTH therapy, multiple sclerosis638–9
ActiGait® 257actinβ-actin, axon tip synthesis
424filamentous (F-actin) 301–2,
307–8microfilaments 423–4
action coding system 512–13action disorganization syndrome
450action potentials (APs)conduction see conductionrecording, implanted
microelectrodes541–2, 556
spike broadening 40, 66spike narrowing 66synaptic transmission 36
action research arm test (ARAT)591, 595
active movements, neglectrehabilitation 468
active range of motiondeforming spastic paresis 313post-stroke, predicting
recovery 334ACTIVE trial 517–18activities of daily living (ADLs)apraxia 457assistive technology 154–7dementia 511disorders of consciousness
397metabolic costs 369recovery after stroke 590–2predicting 593–4
virtual reality applications207–8
visual field rehabilitation and504–5
activities-specific balanceconfidence (ABC) test112
activity-dependent plasticity 241axon sprouting 109CNS extracellular matrix 161sensorimotor function after
spinal cord injury and536–7
spinal cord 83–92synaptogenesis 323–4see also experience-dependent
plasticity, Hebbianplasticity, long-termdepression, long-termpotentiation
activity participationinterventions, dementia527–8
acute inflammatorydemyelinatingpolyradiculoneuropathy(AIDP)see Guillain–Barrésyndrome
acute stage of neurologicaldisease, rehabilitation
see earlyneurorehabilitation
adaptations (functional) 7–8see also compensation
adeno-associated virus (AAV)vectors 247, 515, 517
adenosine triphosphate (ATP)activation of microglia
393–4autonomic function 417Schwann cell signaling 485
adenovirus vectors 515, 517adherent cultures, neural
precursor cells 290–1ADL see activities of daily
livingadrenaline see epinephrineadrenocorticotropic hormone
(ACTH), multiplesclerosis 638–9
adrenoreceptors (AR) 415advancing caregiver training
(ACT) 527aerobic capacity, maximal
see VO2 max
aerobic training 372benefits 373–5multiple sclerosis 646–7recommendations 378see also exercise training
after-hyperpolarization (AHP)amplitude, spinaltransection 177
aggrecan 157, 381activity-related changes in
expression 161secretion after stroke 202
aggression, dementia patients524
agingexercise capacity and 368–9hippocampal neurogenesis and
289neuromuscular junction
morphology and480–1
spinal stretch reflexes and87–8
tactile perception and 141
tinnitus and 134see also elderly
agitationmanagement in dementia
525–7traumatic brain injury 543–4
akinesia, Parkinson’s disease571
akinetic mutism 387AKT-mTOR pathway
see mTOR/mTORpathway
alcohol injections, deformingspastic paresis 319
Allen cognitive level screen-5513
Allen diagnostic module-2 513α-2 adrenergic agonists,
locomotor effects 181,183
α-2 adrenergic antagonists,locomotor effects 181
α-adrenoceptors (α-AR) 415injured spinal cord 178
α coefficient, Cronbach’s 36Alzheimer’s disease (AD)ApoE4 allele and 27, 394apraxia 448–9, 455–7brain reserve capacity and
509–10cognitive/behavioral
assessment 512deep brain stimulation 528eye-blink conditioning
task 26functional neuroimaging
studies 510gene therapy 517–19inflammatory response 393–4learning studies 510, 518–22memory retraining 481–2,
518–20neuronal cell death 258–9, 261,
263, 268–9noninvasive brain stimulation
226, 231, 234pharmacological therapies
479–80risk factors 512
674 Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
virtual reality applications 205see also dementia
amantadinedisorders of consciousness
393, 539–40multiple sclerosis 641multiple system atrophy 425traumatic brain injury
539–41unilateral neglect 469
American Heart Association(AHA), stroke careguidelines 177
American Spinal InjuryAssociation (ASIA)impairment scale 350,531–2, 617–18
α-amino-3-hydroxy-5-methyl-isoxazole-4-propionicacid receptors see AMPAreceptors
4-aminopyridine (4-AP) 458multiple sclerosis 459, 640–1spinal cord injury 249
AMPA receptors (α-amino-3-hydroxy-5-methyl-isoxazole-4-propionicacid receptors, AMPA-R)52
binding proteins 55facilitation 38long-term depression 56–7long-term potentiation 54–5phosphorylation 55stroke recovery and 198–9synaptogenesis 319–20, 323
AMPAkines, stroke recovery and198–9
amphetamines (includingdexamphetamine)
genetic influences on response28
impact on motor training319–20
stroke rehabilitation 12, 242–3traumatic brain injury 539–40
amphibiansspinal cord regeneration
332–3visual system regeneration
333–4see also frogs
amphisomes 267amputationsamphibian regenerative
responses 333brain plasticity after targeted
reinnervation 555cortical reorganization 291–3mechatronic upper limb
prostheses 184–6somatosensory reorganization
77, 245, 291–2see also phantom limb pain/
sensation
amygdalachondroitinase ABC injection
160declarative memory 27, 31
amyloid 264amyloid-β (Aβ) 258–9, 383, 393–4amyloid precursor protein (APP)
259amyotrophic lateral sclerosis
(ALS) 656–8cell death mechanisms 261,
264, 266, 268diaphragmatic pacing 126gene therapy 518, 520inflammation 395–6quality of life 655–8rehabilitation 657–8trophic factors and cell death
259–60Android-based communication
apps 221anesthesia (loss of somatic
sensation) 298anesthesia (regional)motor cortical plasticity 245somatosensory reorganization
245stroke motor recovery and
244, 246angiogenesis, stroke recovery and
15angiopoietins, after stroke 204angiotensin converting enzyme
(ACE) genotype 538angiotensin II 417angle of catch 313anhidrosis 431animal models 232–3
see also preclinical studiesankle–foot orthosesenergy costs of walking and
377–8pressure relief (PRAFO) 397
ankle muscle responses,vestibular inputs 357
ankle strategy, balance control108, 114
annexin A1 (ANXA1) 396–7anomia, mechanisms of recovery
442–3anophthalmia 148anosodiaphoria 469anosognosia 469–71dementia rehabilitation and
513–14for hemiplegia 470for neglect 470–1
antecedent-behavior-consequences (ABC)model 524
anterior cord syndrome 617anterior ectosylvian sulcus (AES)
127–8anticholinergic drugsdystonia 577
multiple sclerosis 641anticipation, facilitating sensory
training 305anticipatory postural
adjustments 108assessment 111treatments addressing 114
antidepressantschronic pain in spinal cord
injury 623epilepsy 559post-stroke depression 608traumatic brain injury 540
antidiuretic hormonesee arginine vasopressin
antiepileptic drugs (AEDs)adverse effects 552–3, 556–8prophylactic, traumatic brain
injury 392, 542anxiety/anxiety disordersafter temporal lobectomy 561critically ill patients 265epilepsy 551, 556postictal 555spinal cord injury 629traumatic brain injury 544
apallic syndrome see vegetativestate
apathy, dementia patients 524ApCAM (Aplysia neuronal
cell adhesion molecule)67
ApCPEB (Aplysia cytoplasmicpolyadenylation element-binding protein) 67–8
aphasia 437–44after temporal lobectomy 561classification 608–9epidemiology 437mechanisms of recovery 441–3pharmacological interventions
242–4prognosis 437rehabilitation 437–44, 608–9assistive technology 152–3behavioral modification 440communication devices 222,226
communication-oriented440
early 271efficacy 443–4holistic vs. localizationist437–8
learning theories 439loss vs. dysfunction oflanguage 438–9
multisystemic view 440–1neoassociationist 440neurobiological basis 441–3neurolinguistic-cognitive440
noninvasive brainstimulation 227–9, 247–8,146–7
pragmatic approaches440
restitution vs. compensation438
stimulation and facilitation439–40
techniques 439–41theoretical basis 437–9training and practice effects241
Aplysia californica 63–71associative learning 68–71behaviors and neural circuitry
63–4nonassociative learning 23,
64–8principles of learning 71
apolipoprotein E (ApoE)genotypes 27–8
apolipoprotein E4 (ApoE4)genotype 27
Alzheimer’s disease risk and27, 394
traumatic brain injuryoutcome and 27,537–8
apoptosis 256, 258developing neurons 256Huntington’s disease 268molecular program 257newly generated neurons in
adult brain 290see also neuronal death,
programed cell deathapoptosome 257Apple 221apraxia 447–58clinical relevance 457clinical testing 455–7cognitive-motor deficits
448–50frontal 447–8, 450historical note 447ideational 447–8, 450ideomotor (limb or
buccofacial) 448–50limbkinetic 448neuroanatomy 453–5syndromes 447–8theoretical models 450–3therapy 457–8
apraxia screen of TULIA (AST)456
ApTBL-1 (Aplysia tolloid/bonemorphogenetic-likeprotein-1) 67
ApUch (Aplysia ubiquitinC-terminal hydrolase)66–7
aquatic therapy, multiplesclerosis 647
arginase I 357arginine vasopressin (AVP,
antidiuretic hormone,ADH) 417, 420, 624
Index
675Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
arm movementscompensatory, brain damage
601–2compensatory trunk
movements assisting 601stretch reflex thresholds 605
artemin 404, 418, 521Ashworth scale, modified 542ASIA scale see American Spinal
Injury Association(ASIA) impairment scale
Aspen criteria, minimallyconscious state 389
asphyxia, perinatal 212aspiration (of gastric contents)
264, 396, 609–10aspirin (acetylsalicylic acid, ASA)
601–2assessment of life habits
(Life-H) 42assistive brain–computer
interfaces 570–1, 579–81assistive devices (assistive
technology, AT) 150–9activities of daily living 154–7assessment for 150–1cognitive impairments 152–4credentialing program 172falls prevention 114, 151–2future 159instrumental activities of daily
living 157–8mechatronic 177neuromotor impairments
151–2sensory perceptual
impairments 154standards 172–3team approach 172
assistive technology professional(ATP) 172
assistive technology professional/seating and mobilityspecialist (ATP/SMS) 172
associative learning 24–6, 63–71Aplysia 68–71emerging principles 71forms 63hippocampal neurogenesis
and 289associativity, long-term
potentiation 51astrocytes 367–9activation after stroke 201Alzheimer’s disease 393–4axon regeneration role 371–2development 368–9functional diversity 367–9after spinal cord injury370–2
functions 367–8, 392GABA uptake after stroke 198glial scar formation 371, 376immature, therapeutic
potential 380
implant–tissue interface 557–8injured spinal cord 448neurogenic potential 286neuronal-type Na+ channels
463–4olfactory ensheathing cell
interactions 503reactive 158–9, 371, 376immature vs. mature 380molecules secreted 381, 383see also astrogliosis, reactiveregulation of synaptogenesis322
replacement therapy, spinalcord injury 442–3
astrogliosis, reactive 158, 286,376
cerebral palsy 213glial scar formation 360, 371growth-promoting molecules
383olfactory ensheathing cell
transplants and 503protective role 376
ataxia, multiple sclerosis 640ATF3 422ATF6 266athletes, spinal cord plasticity
86–7atomoxetine 540ATP see adenosine triphosphate,
Assistive TechnologyProfessional
Atrotech phrenic nervestimulator 126
attentionbalance control and 110, 359genetic factors 27–8selective 495sensory retraining and 305training, neglect 465–9
attention deficit hyperactivitydisorder (ADHD)
in children with epilepsy 553,556, 558
epilepsy risk in 554genetic factors 27–8virtual classroom 203
attention deficitsnoninvasive brain stimulation
227–8traumatic brain injury 540–1virtual reality applications
203–4attentional focusgait training instructions
102internal vs. external 96–7
auditory assessment, disorders ofconsciousness 395
auditory brainstem implants(ABIs) 544
auditory cortex, plasticity 125–35cochlear implants 133congenital deafness 132
during life span 132–3object recognition 129–32spatial functions 125–9tinnitus 133–5
auditory evoked potentials 390–1auditory feedback, virtual reality
systems 200auditory midbrain implants
(AMIs) 544auditory motion perception,
middle temporal (MT)complex 142, 146–7
auditory neglect 465auditory neuroprostheses 544–5
see also cochlear implantsauditory object recognition
129–32auditory perception, blindness
141–2, 145–7auditory rehabilitation, disorders
of consciousness 395–6auditory spatial functions (sound
localization) 125–9blind people 141–2neuroimaging 127–30visual cortical involvement146–7
epigenetic adaptation 125–6visually deprived animals
126–7neural basis 127–9
auditory systemplasticity 125–35transneuronal degeneration 4
augmentation (of synaptictransmission) 36
Ca2+-dependent mechanisms42–3
quantal mechanisms 38synapse specificity 44–5
augmentative and alternativecommunication (AAC)219–28
see also communicationdevices
augmentative and alternativecommunication (AAC)specialists 223
Austrian NeurorehabilitationSociety 261
autism (autistic spectrumdisorders, ASD)
communication support 226–7pathogenic mechanisms 58,
259autonomic dysfunction 415–31cardiovascular system 419–27classification 415–17clinical examination 419clinical features 416–19disorders of consciousness
392–3gastrointestinal tract 428–9localized 416, 418reproductive system 429–30
spinal cord injury 621thermoregulation 430–1traumatic brain injury 543urinary tract 427–9see also orthostatic
hypotensionautonomic dysreflexia/
hyperreflexia 427, 621–2autonomic function assessment,
experimental spinal cordinjury 536
autonomic nervous system(ANS) 415–17
autophagosomes 267autophagy (autophagic cell
death, ACD) 257, 267–9chaperone-mediated (CMA)
267–8molecular regulation 257neurodegenerative diseases
267–9subtypes and steps 267
AVERT trial 269, 603Avery phrenic nerve stimulator
126avoidance learning 27–8axolotl (Ambystoma mexicanum)
284axon(s)collaterals see collaterals,
neuronaldystrophic see dystrophic
growth conesmyelinated see myelinated
axonsspared, conundrum of 9synaptogenesis 318–19tip, local protein synthesis 424unmyelinated 457
axon arbors 10formation of new, after
axotomy 10, 12–14principle of conservation of 12tortuous, suggesting abortive
growth 7, 10, 12axon degeneration 274–9demyelinating diseases 466distal (dying back) 276–7proteins blocking 275–6Wallerian see Wallerian
degenerationWallerian-like 278–9
axon growthafter axotomy 11–12see also axon regenerationbranching mode 10, 12see also axon arborscollateral formation, after
axotomy 12during development 114,
242–3molecular programs, post-
stroke changes 200–1neuron-intrinsic regulators
see neuron-intrinsic
Index
676 Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
determinants ofregeneration
terminology 11–12tract mode 10see also axon sprouting;
growth conesaxon growth inhibitors 308–9,
349–60, 418–19after stroke/brain injury 201–4blocking strategies 354–7categories 201developmentally related 201,
203glial scar-associated
see chondroitin sulfateproteoglycans
myelin-associated see myelin-associated axonal growthinhibitors
vs. neuron-intrinsic regulators345
axon guidance 301–10activity-dependent 109cues (and receptors) 303–7modulating growth coneresponses 308
morphogens 306neurotrophins 306permissive and instructive302
regulation of growth conecytoskeleton 307–8
role in regeneration 309–10,357–60
short- and long-range 302during development 242–3,
302–8, 357–60during regeneration 308–10Sperry chemoaffinity
hypothesis 115–18, 306axon injuryeffects of distance from cell
body 415molecular signaling 416neuronal responses 1–7, 413see also axotomy; denervation;
peripheral nerve injuryaxon regeneration 8–11abortive 7, 9–10canonical (normal target-
specific) 8CNS 339–40developmental loss 414, 425extracellular influences 243glial scar inhibiting 360,376–86
mechanisms limiting 243–4molecules inhibitingsee axon growthinhibitors
obstacles 114overcoming myelin-inducedblock 354–7
strategies for enhancing10–11, 243–5
conditioning lesion effectsee conditioning lesioneffect
disorderly 8ectopic connection formation
10effectors 422–5electrodiagnostic testing 81forms of growth 10glial cell role 371–3guidance 308–10developmental cues 309–10,357–60
inhibitory pathways 309–10identification criteria 9inhibitors see axon growth
inhibitorsinvertebrates 329–30lower vertebrates 329–34neuron-intrinsic determinants
243, 413–26neurotrophins and 402–8, 418non-mammalian models
329–35orderly 8peripheral nervous system
see peripheral nerveregeneration
pitfalls for studies of 8–9priming effects 16region-specific 8retinal ganglion cells see
under retinal ganglioncells
spinal cord injury 339axon–glial cell contacts 10bridges across lesion sites243–4
mechanisms limiting 243–4olfactory ensheathing celltransplants 504–6
PTEN deletion and 11Schwann cell transplants500–1
strategies for enhancing243–5
terminology 11–12vs. axon sprouting 11–12,
343–4see also axon growth, axon
sproutingaxon sprouting 10, 12–15activity-dependent guidance
109corticospinal tract (CST) 5–14,
159factors determining extent
15–17interspecies differences 17myelin-associated axonal
growth inhibitors and343–4
post-stroke 197, 199–201contralateral cortex 199–200ipsilateral cortex 200–2
molecular growth programs200–1
remote intracortical, motorcortex lesions 107
Schwann cell role 475–6,481
Schwann cell transplants intospinal cord 499–500
spinal cord injury 536terminology 11–13triggers 15vs. axon regeneration 11–12,
343–4vs. axonal ingrowth 15vs. generation of new
collaterals 12axonal polyneuropathiescommon causes 79electrodiagnostic testing 79length-dependent 276
axonal transport 422defectsdemyelination 278–9length-dependent axonalneuropathies 277
retrogradeneurotrophins 401signals of axon injury 416
axonotmesis, electrodiagnostictesting 81
axotomy 7, 17axon regeneration after 8–11distal axon degeneration
see Walleriandegeneration
fate of neurons after 4Na+ channel expression 462–3oligodendrocyte death and
demyelination 6–8other types of axon growth
after 11–12retrograde atrophy and
degeneration 4–7site, neuronal response and
415spared axon conundrum 9synapse stripping 6see also axon injury, peripheral
nerve injury
back pain, chronic,neuroplasticity 289–91
backrests, wheelchair 171baclofen 428, 542, 577, 640Bak 263balance 355–64compensatory strategies after
stroke 15, 602importance 105terminology 105–6
balance control 105–10attentional contributions 110,
359cognitive influences 110, 112extrinsic factors affecting 112
resources required 106–10role of eye movements
359–60sensory contributions 107–8,
356–9systems model 106vestibular system role 108,
357–9see also postural control
balance disordersassessment 110–12assistive technology 151–2attentional resources needed
359rehabilitation 112–15see also vestibular dysfunction
balance evaluation systems test(BESTest) 110
balance scale 38, 40–1balance training 105–15attentional focus studies
96–7explicit vs. implicit learning
98Parkinson’s disease 572–3vestibular dysfunction 363virtual reality-based 113, 209
ballet dancers, spinal cordplasticity 86–7
bands of Büngner 472, 496baroreceptors 419–20baroreflex system, bionic 422Barthel Index (BI) 67post-strokepattern of recovery 590–4predictive value 593–4
responsiveness 40–1basal ganglialearning and memory 24praxis 455
basal metabolic rate (BMR) 369,377
base of support (BoS) 105–6basic fibroblast growth factor
(bFGF, FGF-2)astrocyte responses 369glial scar formation 378–9neural precursor cell responses
287, 289oligodendrocyte precursor cell
responses 370regeneration in amphibians
334stroke therapy 248
bathingassistive technology 154–5dementia patients 525
bathroom grab bars 151Bax 263BBB (Basso, Beattie and
Bresnahan) locomotorrating scale 533–4
BCI2000 system 572BCIs see brain-computer
interfaces
Index
677Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
Bcl-2 proteinsmitochondrial function
263–4neuronal death 257–8non-cell death roles 257
BCL-xL 44BDNF see brain-derived
neurotrophic factorbed nuclei of the stria terminalis
(BST) 27bed rest 265–8exercise capacity and 270, 369see also deconditioning
bedside assistive devices 151behavioral change, spinal cord
plasticity and 88–90behavioral disorderschildren with epilepsy 553, 556traumatic brain injury 543–4
behavioral interventionsaphasia 440chronic pain 293–5dementia 516–17, 524–6Parkinson’s disease 571–2somatosensory loss 80
behavioral problems in dementia522
assessment 511–14conceptual frameworks 523–4interventions 516–17, 524–7models guiding treatment
514–15Bergman glia 368–9Berlin apraxia test (BAXT)
456–7Berlin LSVT®BIG study 570BESTest (Balance Evaluation
Systems Test) 110β-adrenoceptors (β-AR) 415β-amyloid see amyloid-βbiasin clinical trials 234in prognostic studies 587–9
Bienenstock–Cooper–Munro(BCM) model 56–7
bilateral arm training withrhythmic auditory cueing(BATRAC) 90
bilingual humans 131Binswanger’s disease 569biofeedbackmemory dysfunction 481sensory, balance rehabilitation
114see also feedback
biomechanical constraints onbalance 106
assessment 110treatment 112
biomechanical factors, energyexpenditure 374–6
biomimetic neural prosthesessee neural prostheses
BION® device 1302,20-bipyridine (BPY) 159
birds, adult neurogenesis 285Blackrock microelectrode array
577bladder care, disorders of
consciousness 392bladder controlassessment, experimental
spinal cord injury 536development 85
bladder dysfunction 427–9functional electrical
stimulation 129–30multiple sclerosis 641, 648neural prostheses 543spinal cord injury 427–8, 621
blast injuries 385–6, 535blepharospasm 574–5, 577–8blinded clinical trials 234blindfolding, tactile
discrimination after141, 144
blindness 144–8age at development 140auditory object recognition 132auditory spatial function
126–30, 141–2cortical 502modality-independence of
perceptual-cognitivefunctions 147
neuroanatomical studies 147–8nonvisual perception 140–2somatosensory cortical
plasticity 142visual cortical involvement in
nonvisual tasks 144–7visual neuroprostheses 545–6,
554–5see also visual deprivation
blindsight 502blood–brain barrier (BBB) 368breakdown, glial scar
formation 378microelectrode implantation
disrupting 555–7blood pressurechanges in orthostatic
hypotension 420–1control 419–20
blunt brain injuries 385body weight support system
(BWSS) 628body weight-supported treadmill
training (BWSTT) 64–6,369
multiple sclerosis 647spinal cord injury 65, 630stroke 65, 372, 374, 607
bone marrow stromal cells448
see also mesenchymal stemcells
bone morphogenetic proteins(BMP)
axon guidance 306
induced astrocytes, spinal cordtransplants 370, 372,443–4
neural precursor cell responses287
botulinum toxin (BTX)injections
bladder dysfunction 428, 641dystonia 577hemiplegic shoulder pain 607spasticity 319, 604–5, 640
bound Ca2+ model, facilitation41
bowel care, disorders ofconsciousness 392
bowel functionassessment, experimental
spinal cord injury 536multiple sclerosis 641sacral anterior root
stimulation and 130spinal cord injury 429, 621
BPY (2,20-bipyridine) 159bradykinesia, Parkinson’s disease
571Braille readerssomatosensory cortical
plasticity 142tactile perception 140–1
Braille readingmodality-independent visual
cortical functions 147visual cortical involvement
144–5, 147brainplasticity see plasticityreserve capacity 509–10responses to neural prostheses
see under neuralprostheses
brain–computer interfaces(BCIs) 549–50, 565–73
applications 571–2definition 565–6dementia 528–9direct speech 579invasive see intracranial
brain–computerinterfaces
moderately invasive seeelectrocorticography(ECoG)-basedbrain–computerinterfaces
motor 570–2, 579–81noninvasive see electroen
cephalography (EEG)-based brain–computerinterfaces
potential users 570–1present-day types 567–70principles of operation 566–7process control vs. goal
selection 571–2research and development 572
selectivity–invasivenesstradeoff 556
signal processing 570signal recording methods 567,
577therapeutic uses 571
brain damage see brain injurybrain-derived neurotrophic
factor (BDNF) 400amyotrophic lateral sclerosis,
gene therapy 520exercise training and 373–4Huntington’s disease, gene
therapy 520neural precursor cell responses
287neuropathological role 258–9peripheral nerve injuryaxon regeneration and403–4
cell survival and 402plasticity-related functions
26–8receptor 400regulation of synaptogenesis
322–3spinal cord injuryaxon regeneration and405–6, 418
cell survival and 405effects on specific fibertracts 408
functional effects 180, 184,406–7
gene therapy 521increased expression 405methods of administration406
with Schwann cell grafts501–2
stroke recovery and 13, 199,603
val66met gene polymorphism26–8
brain disorders see brain injurybrain injurycellular mechanisms of
plasticity 196–207axon growth inhibitors201–4
axonal sprouting/newconnections 199–201
cellular regeneration 204–5excitatory signaling 197–9functional imaging 196–7
cognitive rehabilitation seecognitive rehabilitation
etiologies 385–7motor compensation after
600–2motor cortex reorganization
52–3, 55perinatal see perinatal brain
injurysecondary 543
Index
678 Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
stem cell therapies 586–93traumatic see traumatic brain
injurysee also specific conditions
brain–machine interfaces (BMIs)see brain-computerinterfaces
brain size, reserve capacity and509
brain stimulation 141–7genetic influences on response
29see also deep brain stimulation,
non-invasive brainstimulation
brain tumors, hippocampalneurogenesis and 294
BrainGate device 549, 578brainstem auditory evoked
responses (BAERs)390–1
breathing assistance, hightetraplegia 126
brevican 157, 381bromocriptine 540–1bromodeoxyuridine (BrdU)
labeling, neural precursorcells 291–2
Brown–Séquard syndrome 169,617
buffer saturation model,facilitation 42
bulbospinal projections,locomotor control 169
Bundesarbeitsgemeinschaft fürRehabilitation (BAR),Phasenmodell der 261
buspirone 182
C-Mill treadmill 100–3C3 transferase 421cadherins 323, 484Caenorhabditis elegansaxon guidance 304–5axon regeneration 329–30calcium signaling 416specificity of synaptic
connections 323caffeine 424CAG triplet repeat diseases
see polyglutamine(polyQ) repeat diseases
Cajal, Ramón y see Ramón yCajal
calbindin 42calcineurin, long-term
depression 56calcium (Ca2+)cell death in degenerative
diseases 262current facilitation 40–1extrusion, presynaptic
terminals 40growth cone motility and
422
mitochondrial handling 37, 40,42–4
postsynaptic signalinglong-term depression 56long-term potentiation53–4
long-term sensitization 67presynaptic signaling 36–43delayed asynchronousrelease 40
phasic release 39residual [Ca2+] 39–40short-term synapticenhancement and 40–3
signaling in axon injury 416uncaging 39Wallerian degeneration and
275calcium (Ca2+)/calmodulin-
activated kinase II(CaMK II)
long-term depression 56long-term potentiation 53–5post-tetanic potentiation 43
calyx of Held 39Canadian neurological scale
(CNS) 593canes, walking 114, 156cannabinoids 640CAP-23 424captopril 427carbamazepine (CBZ) 552–3cardiovascular diseaseexercise capacity and 369–71spinal cord injury 421, 623stroke patients 263, 268
cardiovascular systemacute responses to exercise
367–8, 370assessment in spinal cord
injury 621autonomic disorders 419–27effects of inactivity 268, 369training-induced adaptations
372Care of Persons with Dementia
in their Environments(COPE) 527
care pathways see clinicalpathways
caregiversamyotrophic lateral sclerosis
658dementia rehabilitation role
522–8formal and informal 523
CAREN™ multisensory system200–1, 206–7
carotid sinus hypersensitivity(CSH) 425
carotid sinus massage 421carpal tunnel syndrome,
wheelchair users 161case manager 285caspases
neurodegenerative disorders259
neuronal death 257–8non-cell death roles 257
casting 316catechol-O-methyl transferase
(COMT) gene 28–30,538
catechol-O-methyl transferase(COMT) inhibitors 568
Catherine Bergego scale 470–1cationic liposomes 515Catwalk device 533–5cauda equina syndrome 617CAVE virtual reality system 200Cdc42 307–8, 359ceiling effects, outcome measures
41cell adhesion moleculesaxon regeneration role 425,
484neuronal regenerative ability
and 415cell death 256–7necrotic 256see also apoptosis, autophagy,
neuronal death,programed cell death
cell phones (mobile phones)reminder systems 483–4see also smartphones
cell replacement therapies, spinalcord injury 435–50
alternative sources of cells 448cell delivery methods 449clinical trials 442, 449–50development and properties of
cells 437–9fetal tissue transplants 436–7mobilizing endogenous
precursors 448–9neural stem and precursor cell
transplants 380, 439–48practical issues 449–50properties of candidate cells
439–40rationale 436relay formation 446–8time of engraftment 449see also cellular therapies, stem
cell therapiescell survival, neuronal
see neuronal survivalcellular therapiesbased on endogenous
precursors 294–5, 448–9demyelinating diseases 465for-profit centers 449–50gene therapy approaches
514spinal cord injury 496–508,
588–90, 592, 631olfactory ensheathingcell transplants 496,502–8
Schwann cell transplants496–502, 508
trophic factor-secreting cells521
see also cell replacementtherapies; stem celltherapies
center of body mass (CoM)105–6
Centers for Medicare andMedicaid Services (CMS)127, 163, 286
central cord syndrome 617central nervous system (CNS)
injuryaxon regeneration see axon
regenerationglial scar see glial scarinflammatory response
392–7neural consequences 317neuronal effects 1–2neurotrophins and repair
405–8oligodendrocyte death and
demyelination 6–8reactive growth responses of
neurons 1–7reorganization of neuronal
connections 8–17sensory loss 298–9see also brain injury, spinal
cord injurycentral nervous system (CNS)
stimulants 393, 528, 540central pattern generator (CPG)locomotor 83–4, 61–2cats 166–9changes after spinal cordinjury 177
coordinating interneurons173
human 343–4, 348mice 176–7rats 171–2
swallowing 406–7CERE-110 (AAV-NGF) 519cereal-eating test 535–6cerebellar Purkinje cells 26, 56channelopathy in
demyelinating disease462, 464
cerebellins 321–2cerebellumcontralesional hypoactivity
317learning and memory 25–6lesions, spinal fixation 84long-term depression 26,
56–7M1 connectivity 143
cerebral blood flowduring exercise 368regional (rCBF) 84stroke 12
Index
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cerebral cortexcontralateral, axon sprouting
after stroke 199–200experience-dependent
plasticityipsilateral, axon sprouting
after stroke 200see also neocortex
cerebral edema, post-stroke 602cerebral motor functions 99–110organization 99–103plasticity 103–9see also motor cortex
cerebral palsy (CP) 211–16abnormal corticospinal
connections 85–6exercise capacity 370exercise training 375gait disorder 347infantile spinal stretch reflexes
85–6neural plasticity 215–16pathophysiology 212–15underlying perinatal brain
injuries 211–12virtual reality applications 210,
212cervical dystonia (spasmodic
torticollis) 575–6medical and surgical treatment
577–8rehabilitation 578
cervical spinal cord,propriospinal pathways175
cervical spinal cord injuryautonomic dysfunction 421clinical trial endpoints 237–9forelimb motor recovery
measures 532–5locomotor recovery in rats 171nonhuman primates 537recovery and functional
outcomes 625–7upper extremity
neuroprostheses 546–7see also tetraplegia
chair, rising from a 42channelopathy, demyelinating
disease 462, 464chaperone-mediated autophagy
(CMA) 267–8chaperones, neurodegenerative
diseases 264–7Charcot–Marie–Tooth diseasedemyelinating forms, axonal
loss 278type 2A 277type 2B 277
charge storage capacity (CSC)542
chemoaffinity (orchemospecificity)hypothesis, Sperry’s115–18, 306, 334
childrencochlear implants 544with complex communication
needs 224–5with epilepsycognitive impairments 552management 557–8psychiatric/behavioralproblems 553–4, 556
psychosocial impact 551otitis media 132virtual reality applications
203–4, 210wheelchair design 169see also cerebral palsy;
perinatal brain injurycholesterol, synapse formation
and 322cholinergic polymorphisms 29cholinesterase inhibitors
see acetylcholinesterase(AChE) inhibitors
chondroitin sulfateproteoglycans (CSPGs)155–7, 381–2
axon growth inhibition 158,309, 344–5, 360, 381
axon regeneration inhibition243, 378, 381–2, 419
ocular dominance plasticityand 345
receptors 344–5, 381–2secretion after CNS injury
201–3, 381signaling, as therapeutic target
385as therapeutic target 159–60,
244, 384–5chondroitinase (Ch’ase, chABC)
157inhibition of scar formation 159promoting axon regeneration
381, 384–5spinal cord injury 6, 80,
159–60, 244chronic phase 161with rehabilitation 161with Schwann cell grafts 501
chorioamnionitis 212CHRNA4 gene 28chronic inflammatory
demyelinatingpolyneuropathy (CIDP)662–3
concurrent diseases 80electrodiagnostic testing 79–80
chronic pain 289–95behavioral interventions
293–5musculoskeletal
see musculoskeletal pain,chronic
pharmacological interventions295
plasticity and 289–93
spinal cord injury 623see also neuropathic pain
ciliary neurotrophic factor(CNTF)
astrocytes induced by 370, 372derived astrocytes, spinal cord
transplants 443–4gene therapyamyotrophic lateral sclerosis520
Huntington’s disease 520inducing axon regeneration
385, 417cingulate motor area (CMA) 53,
55, 103post-stroke changes 85–6
citalopram 29, 320citicholine 539classical (Pavlovian)
conditioning 24–7, 63cellular analog 51neural mechanisms in Aplysia
68–70pain-related responses 291
classical test theory 35–8clavicle, osteolysis of distal 161climbing fibers, cerebellar 26, 56clinical pathways 70–6, 281benefits and risks 72continuous team education 72definition and characteristics
71design and implementation
74–5evidence for efficacy 72–4
clinical practice guidelines 70clinical test for sensory
integration in balance(CTSIB) 110–11
clinical trials 1–6, 231–40biological interventions 2confounding factors 5–6,
238–40CONSORT checklist 2–3inclusion/exclusion criteria
232–4interventions 4methodological quality 11outcome measures 4–5, 235–8phases and stages 1–2, 236–7preclinical criteria prior to
231–2principles for conduct of valid
239–40randomization 2–4, 234–5study designs 2–5, 234–5see also randomized controlled
trialsclonazepam 640clonidinechallenge, autonomic
dysfunction 422locomotor effects 181, 183
clothing fasteners 155cluster headache 293
CNS see central nervous systemcochlear implants (CI) 133,
544–5, 554plastic responses 555
cognitive activities, dementiaprevention 511, 518
cognitive behavioral therapy(CBT)
epilepsy 559post-stroke depression 608
cognitive functionassessment in dementia
511–14balance control 110, 112language interactions 440–1
cognitive impairmentsafter temporal lobectomy
560–1assistive technology 152–4communication support 225–6epilepsy 551–2, 557–8learning by individuals with
515–17multiple sclerosis 641transient, epilepsy 552traumatic brain injury 543virtual reality applications
203–8see also dementia, mild
cognitive impairment,specific deficits
cognitive neuroscientific models,dementia 514
cognitive orthotics 153cognitive rehabilitation 218–35challenges 218–19definition 218dementia 515memory dysfunction 481noninvasive brain stimulation
146–7, 219–35choice of technique 221clinical evidence 227–31diagnostic applications223–4
with other therapeuticinterventions 224–5
technical and otherchallenges 225–7
theoretical framework221–3
online training programs 219virtual reality systems 203–7
cognitive reserve 509cognitive stimulation, in
dementia 514–15, 526cognitive tasks, secondaryduring balance tasks 112, 359improving motor learning
97–8see also dual-task paradigms
cognitive trainingdementia 514–15healthy older people 517–18memory dysfunction 481
Index
680 Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
multiple sclerosis 648–9cohort, prospective inception
589collagen, after spinal cord injury
158–9collagenous scar 158–9collaterals, neuronalgrowth of new, after injury 10,
12–14principle of sustaining 5
coma 262, 387coma near coma scale 389coma recovery scale–revised
(CRS-R) 389commissureless (Comm) 308commodes, bedside 156communication devices 152–3,
219–28control inputs 220–1direct speech brain–computer
interfaces 579disorders of consciousness 397funding 223–4, 226mobile devices and apps
221–3, 225outputs 220–1selection of dedicated 223specific clinical populations
224–7types available 219–20visual scene approach 220,
222, 225–6web resources 230
communication-orientedapproaches, aphasiarehabilitation 440
communication systems,disorders ofconsciousness 395–7
compensation 7, 599–605adaptive 7–8after brain damage 600–2aphasia 438balance rehabilitation
112–13definitions 7–8, 599–600measurement 605mechanisms 602–5motor map plasticity and 109neural 509noninvasive brain stimulation
promoting 222redundancy and 603–5stroke recovery and 15–16substitutive see substitutionvs. neural repair 8–9see also motor compensation
compensatory plasticity 91competence-environmental press
model (CEPM) 523complex regional pain syndrome
(CRPS) 293compound motor action
potential (CMAP)80–2
compressive neuropathies,electrodiagnostic testing78, 81
computed tomography (CT),head injury 536
computer adapted testing (CAT)38–9
computer-assisted scaleadministration 38
computer trainingmemory deficits 480unilateral neglect 469
computersfor word processing 158see also mobile electronic
devices, tablet computersCOMT (catechol-O-methyl
transferase) gene 28–30,538
conditioningclassical (Pavlovian)
see classical conditioningcontextual 30fear see fear conditioningoperant see operant
conditioningtrace 29–30see also learning
conditioning lesion effect 379,416, 245
cAMP dependence 356, 379conduction (action potential)
459–60continuous, demyelinated
axons 460–1demyelinated/dysmyelinated
axons 459–60discontinuous, recovering
demyelinated axons 462myelinated axons 457, 459remyelinated axons 464–5slowed 459spinal cord axons
remyelinated by Schwanncells 498–9
temporal dispersion 459unmyelinated axons 457see also nerve conduction
studiesconduction block 459–60electrodiagnostic testing 78frequency-related 460impedance mismatch/
matching and 464–5role of blocking factors 460total 460
cone electrode 577confounders, clinical trials 5–6,
238–40connections, neuronal
see neuronal connectionsconsciousness, disorders of
385–400acute rehabilitation 391–400facilitating plasticity 394
goals 394–5medical and nursing care392–3
prognostic evaluation398–9
programs and protocols394–8
clinical assessment 391clinical presentations 262–3,
387–8diagnostic procedures 388–91duration, predictive value 399etiologies 385–7evoked potentials 390–1neurobehavioral evaluation
388–90neuroimaging 390
CONSORT (consolidatedstandards of reportingtrials) checklist 2–3
Consortium for Spinal CordMedicine 532, 162
constipation 429constrained action hypothesis,
external focus ofattention 96
constrained-induced aphasiatherapy (CIAT),memantine with 244
constraint-induced movementtherapy (CIMT) 10, 337,606–7
early intensive 16, 335–6increased sensory input 136outcome measures 338timing 241
construct validity 37contact heat evoked potentials
(CHEP) 618–19content validity 36–7context specificity of training
see specificity of trainingcontextual conditioning 30contextual-interference effect
98–9contiguity, in associative learning
24contingency, in associative
learning 24continuous performance tasks
(CPT), virtual classroom203
continuous team education 72contracts, self-rehabilitation
321contracturescasting and serial casting 316chronic stretch 314–15disorders of consciousness 397spastic paresis 312
contrecoup brain injury 385control groups 4, 234–5conus medullaris syndrome 617cooling therapy, multiple
sclerosis 647–8
cooperativity, long-termpotentiation 51
coordinative structures, motorcontrol 603
Copenhagen stroke study 593Cornichon proteins 55corpus callosum, surgical
transection 560cortical map plasticityafter stroke 13–14see also under motor cortex
cortical motoneurons (CM cells)101–2
changes after stroke 85–6degeneration after spinal cord
injury 5–6see also corticospinal tractaxons, upper motorneurons
cortical visual prostheses 545–6corticobasal degeneration (CBD)
569–70apraxia 448–9, 454, 457inflammatory response 394
corticospinal tract (CST)activity-dependent plasticity
88during development 85–6
lesionslocomotor recovery 169, 173neurotrophin-3 genetherapy 521
Nogo-A antibody therapy179
olfactory ensheathing celltransplants 504–5
recovery and compensationfor 57
retrograde neuronaldegeneration 5–6
Schwann cell accumulation498
stroke 56, 87origins and pathways 55–6regeneration from endogenous
progenitor cells 445stroke recovery and 14, 333,
596voluntary motor control
55–6corticospinal tract axons 55–6regeneration 11cerebral palsy 215gene knockout studies342–3
neurotrophins and 408sprouting 5–14, 159see also upper motor neurons
corticostriatal fibers, effects ofcortical injury 107
COSMIN checklist 39cost–benefit analysis,
rehabilitation robotics181
cough, aspiration risk and 264
Index
681Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
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coup brain injury 385cranial nerve palsies, after
temporal lobectomy 563CREB see cyclic AMP response
element-binding proteincredentialing, assistive
technology 172criterion-related validity 37critical illness 264–5critical illness myopathy (CIM)
264–5, 663, 666critical illness polyneuropathy
(CIP) 264–5, 663critical pathways see clinical
pathwayscritical periods (sensitive periods)acquisition of musical abilities
131auditory system development
132–3functional recovery after CNS
injury 371language acquisition 131locomotor recovery in
spinalized rats 171metaplasticity after stroke 206for plasticity, termination by
perineuronal nets 156–7stroke recovery 17, 202, 595–6visual system development 140
Cronbach’s α coefficient 36cross-modal plasticity, visual
system 140–8cross-talk, pathological 460crossover studies 235crustaceans, axon regeneration
329–30CSPG see chondroitin sulfate
proteoglycanscueing techniquesgait training 66Parkinson’s disease 571–2unilateral neglect 467–8
cuneate nucleus, changes aftersensory loss 78–9
CX3CL1 (fractalkine) 396CX3CL1R (fractalkine receptor)
396cybernetics 184cybersickness 199cyclic AMP (cAMP)axon guidance 308conditioning lesion effect
356, 379downstream effects, as
therapeutic targets 356–7infusion, spinal cord injury
159modulation of axon
regeneration 355–6,419–21
Schwann cell grafts into spinalcord and 502
cyclic AMP/protein kinaseA (cAMP/PKA) pathway
axon regeneration and 356mediating sensitization 65–7
cyclic AMP response element-binding protein-1(CREB1) 66–7
cyclic AMP response element-binding protein-2(CREB2) 67, 416
cyclic GMP (cGMP), axonguidance 308, 420
cyclic nucleotides, modulation ofaxon regeneration 420–1
cytokinesaxon regeneration and 416–18cerebral palsy 215inflammatory response 393responses to implanted devices
557cytoskeletal proteinsaxon regeneration role 422–4axonal transport 422Schwann cells 485synthesis in axon tip 424
cytoskeletongranular disintegration,
degenerating axons 275growth cone 301–2, 422–3regulation 307–8
cytoskeleton-associated proteinof 23 kDa (CAP-23) 424
dantrolene 542Data Safety Monitoring Board
(DSMB) 235DCC (deleted in colorectal
cancer) receptoraxon guidance 304, 308netrin binding 358
deafness see hearing impairmentdeconditioning 367effects of exercise training
372–4neurological disorders 369–72see also bed rest
deep brain stimulation (DBS)543–4
dementia 528dystonia 577–8Parkinson’s disease 345,
543–4, 568–9tinnitus 135vs. intracortical
brain–computerinterfaces 577
deep venous thrombosis (DVT),spinal cord injury 620–2
default mode, transcending the492
Defense Advanced ResearchProjects Agency(DARPA) 184–6
deficit-compensating strategy600
degenerationaxon see axon degeneration
cascading 6delayedneuronal, after ischemia 6oligodendrocytes, afteraxonal injury 6–8
retrograde, after axotomy 4–7transneuronal, after
denervation 4Wallerian see Wallerian
degenerationdegenerative diseases
see neurodegenerativediseases
DEKA Gen 2 arm system 185delayed non-matching to sample
task 30–1delirium 265dementia 529behavioral problems
see behavioral problemsin dementia
cognitive/behavioralassessment 511–14
cognitive neuroscientificmodels 514
neurogenesis theory 294new medications and devices
528–9Parkinson’s disease 569prevention 511rehabilitation 529caregiver involvement522–8
cholinesterase inhibitortherapy with 522
efficacy of learning 517–22learning theory and 515–17models 514–15neural substrate supporting509–10
relevance 510–11risk factors 512semantic, apraxia 449–50vascular see vascular dementia
dementia of Alzheimer’s type(DAT) see Alzheimer’sdisease
dementia with Lewy bodies(DLB) 569
demyelinated axons 457–67conduction abnormalities
459–60continuous conduction 460–1discontinuous conduction 462impedance mismatch/
matching 464–5molecular remodeling 462Na+ channel transfer from glia
462–4demyelinating diseasesaxonal degeneration 278cell transplantation 465neuroprotection of axons 466potassium channel blockers
459
sodium channelopathy 462,464
demyelinating polyneuropathiesaxonal degeneration 278electrodiagnostic studies 79–80
demyelination 457axonal degeneration 278–9trauma-induced 6–8
dendrites 3–4, 318–19dendritic cells 393dendritic spines 318, 324denervation 2–4diffuse vs. concentrated 15–16fate of CNS neurons after 2neuronal structural
modifications 3–4neurotransmitter receptor
changes 2–3reinnervation after
see reinnervationtransneuronal atrophy 3–4transneuronal degeneration 4see also axon injury, axotomy
denervation supersensitivity 2–3denial 469dental hygiene 155dentate gyrus (DG), adult
neurogenesis 285, 288–90depression (clinical)after temporal lobectomy 561critically ill patients 265deep brain stimulation 544in epilepsy 551, 553–6, 558–9epilepsy risk in 554genetic factors 28hippocampal neurogenesis 294multiple sclerosis 641post-stroke 607–8postictal 555spinal cord injury 620, 628–9traumatic brain injury 544
depression (neural)long term see long-term
depressionmechanisms in Aplysia 64–5short term see short-term
depressiondermatomyositis 80, 665–6descending pathwayschanges in injured spinal cord
179–80control of locomotion 167,
172–6control of spinal reflexes 85specific effects of
neurotrophins 407–8spinal cord plasticity after
lesions to 84stroke-related injury 86, 90–1voluntary motor control 55–7
descriptive studies 2desmopressin 424, 428developmentastrocyte function 368axon growth 114, 242–3
Index
682 Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
axon guidance 242–3, 302–8,357–60
neural cell 368neuromuscular synapse
remodeling 482neuronal cell death 255–8molecular regulation257–8
morphological features256–7
neurotrophic hypothesis 255,257, 400
retinotectal pathway 114–18somatosensory system
plasticity 79–80spinal cord plasticity 84–6trophic factors in neural 255
developmental ageaxonal growth after
transection and 12reinnervation of denervated
neurons and 16–17developmentally related axon
growth inhibitors 201,203
dexamethasone (DEX) 560dexamphetamine
see amphetaminesdexanabinol 539dexterity, manual see hand
functiondiabetes insipidus 541diabetes mellitusgastrointestinal dysfunction
429type II, spinal cord injury
624diabetic neuropathy 79, 81,
663–4diaphragmatic pacing 126diaschisis after stroke, recovery
from 12, 602diazepam 640dietitian 283differential learning 99–100diffuse axonal injury (DAI) 385,
399, 537diffusion tensor imaging (DTI)disorders of consciousness 399predicting stroke recovery
43–4, 90, 596with transcranial magnetic
stimulation 224traumatic brain injury 537
digital voice recorders 153dihydroergotamine 423–4L-threo-3-4-
dihydroxyphenylserine(L-DOPS) 424
disability assessment scale 313disinhibition (unmasking) 240somatosensory system injury
76, 78disorders of consciousness scale
(DOCS) 389–91, 399
distal axonal degeneration(DAD) 276–7
distributed network effects,noninvasive brainstimulation 222–3
dizziness, post-traumatic 544DKL-1 416donepezil 244, 479–80, 541, 641dopaminecontrol of locomotion 183, 344denervation supersensitivity 2reward learning 27
dopamine agonistsimpact on motor training 320locomotor recovery in spinal
animals 182Parkinson’s disease 567–8stroke rehabilitation 243–4traumatic brain injury 539–41unilateral neglect 469
dopamine β-hydroxylase (DβH)deficiency 424
dopamine transporter gene 28L-DOPS (L-threo-3-4-
dihydroxyphenylserine)424
dorsal column lesionschondroitinase ABC therapy
159–60locomotor recovery in cats 169somatosensory system
plasticity 78–9dorsal funiculus, locomotor
control in rats 172–3dorsal premotor cortex
(PMd and prePMd) 53,99–100, 103
reorganization after stroke85–6, 89
voluntary motor control 55dorsal root ganglion (DRG)
neuronscAMP dependence of
conditioning lesion effect356
CSPGs and regeneration 382cytoskeletal proteins in
regenerating 423neurotrophins and
regeneration 403–4, 418see also sensory neurons
dorsal root injury,somatosensory systemplasticity 77
dorsolateral funiculus (DLF)lesions, locomotor recovery in
cats 169locomotor control in cats 167
Dosset boxes 484double blind clinical trials 234Down’s syndrome (DS) 259, 210,
370, 375Dragon (RGMb) 306–7dressingassessment in dementia 513
assistive technology 155dressing sticks 155drinking, assistive technology
156drivingspinal cord injury 625–7virtual reality applications
207–8drop foot see foot dropDrosophila melanogasteraxon guidance 303–4, 308specificity of synaptic
connections 323Wallerian degeneration 276
drug-induced myopathies 80dSarm 276Dscam 304, 323dual-task paradigmsAlzheimer’s disease 519balance control 112, 359virtual reality 205–7see also cognitive tasks,
secondaryDuncan, Carl 27–8dying back, axonal 276–7dynactins 422dynamic gait index 42, 112dynamic postural stability during
gait 109–10assessment 112treatments to enhance 114
dynamic post-urography 110–13dynamic splints 315dynamic turnover, principle of
16–17dynamic visual acuity (DVA)
testing 360–1dynamin-related protein 1
(DRP-1) 262–3dynein 422dysexecutive syndrome 489–91
see also executive dysfunctiondysmyelinated axons 457–67conduction abnormalities
459–60Na+ channels 461see also demyelinated axons
dysmyelination 457dysphagia 405–12causes 407disorders of consciousness
396–7evaluation see swallowing,
evaluationlearned non-use 411–12multiple sclerosis 648Parkinson’s disease 574pharyngeal stimulation 138,
245, 410–11recovery 409–10treatment 407–11acute phase 264alternative explanations ofeffects 412
effects on plasticity 409–11
multiple sclerosis 648negative effects 412outcome measures 409Parkinson’s disease 574rehabilitative 408–9stroke 609–10
dystonia 567, 574–9classification 574–5clinical features and diagnosis
576–7focal hand see hand dystonia,
focalgenetics 575–6medical and surgical treatment
577–8neurobiology 555, 576Oppenheim (DYT1) 575–6rehabilitation 578–9
dystrophic growth cones(dystrophic axons) 7,9–10, 376–8
cellular interactions 380stabilization by NG2+ cells
384DYT1 gene polymorphism 30
e-books 158early neurorehabilitation 261–72bed rest and its consequences
265–8clinical syndromes 262–3comorbidity and
complications 263–4critical illness 264–5interventions 268–71organization 271–2, 279–80upper extremity 270–1, 335–6
eating, assistive technology 156ecological validity 25economicsclinical pathways 73neurorehabilitation 285–6traumatic brain injury 535
ectopic impulse generation 460Edinburgh virtual errands test
(EVET) 206educationcontinuous team 72epilepsy 559falls prevention 114
educational leveldementia development and
509–10impact of epilepsy 551, 556–7spinal muscular atrophy 658–9
EEG see electroencephalographyeffect size 38ejaculation, retrograde 429elderlyauditory function 132–3carotid sinus hypersensitivity
425cognitive remediation studies
517–18dementia prevention 511
Index
683Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
elderly (cont.)efficacy of aphasia
rehabilitation 444falls 105motor learning strategies 97stroke recovery 9see also aging
electric powered wheelchairs(EPW) 165–8
electrical feedback approaches528
electrical stimulationbiomimetic neural prostheses
542injured spinal cord in animal
models 183–4neuromodulation approaches
543–4paired associative, spastic
paresis 321see also brain stimulation,
functional electricalstimulation, peripheralnerve stimulation
electroconvulsive shock (ECS),memory dysfunction27–8
electrocorticography (ECoG)-based brain–computerinterfaces 549, 567
clinical use 577methods 568–9vs. intracortical BCIs 578
electrodesfunctional electrical
stimulation systems121–2, 254–5
implantable 121–2, 255intracranial brain–computer
interfaces 577–9surface 121, 254–5see also microelectrodes,
implantedelectrodiagnostic tests 77–82spinal cord injury 617–19see also electromyography,
nerve conductionstudies
electroejaculation 130, 430, 631electroencephalography (EEG) 565after stroke 87predicting recovery from brain
injury 399electroencephalography (EEG)-
based brain–computerinterfaces (BCIs) 549, 567
methods 567–8vs. intracortical BCIs 578
electromyography (EMG) 77–82assessment of weakness 77–80basic principles 77gait analysis 62, 81, 343interpretation of report 81in movement 80–1outcome assessment 81–2
powered orthoses using 184spinal cord injury 619surface (SEMG) 80–1
electronic aids for daily living(EADLs) 152
electronic memory aids 483–4eMagin head-mounted display
(HMD) 200–1embodied cognition theory 441embryonic stem (ES) cellsderived motor neurons, spinal
cord transplants 444–5directed differentiation 437isolation and properties 439neural induction 439spinal cord transplants 442,
449, 589emotional disorders
see psychiatric disordersemploymentafter temporal lobectomy 562epilepsy and 551, 556–8polio patients 660
encephalopathy of prematurity211
endocrine dysfunctionspinal cord injury 624traumatic brain injury 541
endoneurial tubes, peripheralaxon regeneration along473–4
endoplasmic reticulum (ER)stress 262, 264–7
enduranceimmobility and 270local muscular 331walking tests measuring 42
endurance training, multiplesclerosis 646–7
energy conservation course,multiple sclerosis 648
energy expenditure 374–8biomechanical and metabolic
factors 374–6effects of rehabilitation 377–8factors affecting 376–7
enriched environmentsadult neurogenesis and 289stroke recovery and 603
enrichment strategies,rehabilitation trials 5
enteral nutrition see tube feedingenteric nervous system 415entrainment enhancement,
noninvasive brainstimulation 223
entrapment neuropathies 78environment 279enriched see enriched
environmentsinfluences on balance control
112environmental control devices/
units (ECUs) 150, 152,625
environmental cueing, memorydysfunction 515
environmental dependencysyndrome 490
environmental modificationfalls prevention 114–15memory dysfunction 485
environmental skill-buildingprogram (ESP) 527
ependymal cells 392injured spinal cord 448
Eph receptorsaxon guidance 306regulation of synaptogenesis
321, 323retinotectal pathway
development 116retinotectal pathway
regeneration 118–19ephedrine 423ephexin 359ephrins 203axon guidance 306axon regeneration 309, 344,
359–60, 383changes after stroke 203regulation of synaptogenesis
321, 323retinotectal pathway
development 116retinotectal pathway
regeneration 118–19epidermal growth factor (EGF)astrocyte development 369neural precursor cell responses
287, 289epidural spinal cord stimulation
183–4, 548epigenetic adaptation, sound
localization cues 125–6epilepsy 550–63cognitive impairments 551–2,
557–8gene therapy 522impact on patients’ lives 550–1obstacles to personal and
social development 551–7pediatric see children, with
epilepsypost-traumatic 392, 542psychiatric disorders 550–1,
553–6, 558–60psychosocial problems 556–7,
559rehabilitation 550–63epilepsy surgery and 559–63need for 550strategies 557–9
surgery 559–63see also seizures
epileptic aphasia of childhood,acquired 550
epimysial electrodes 121, 255epinephrine (E)autonomic function 417
facilitation of memory 28plasma, orthostatic
hypotension 421–2epithelial V-like antigen (EVA-1)
305erectile dysfunction 429–30, 641ergometry, functional electrical
stimulation 125, 630ERGYS clinical rehabilitation
system 125ERK (extracellular-regulated
kinase) pathwayaxon injury 416axon regeneration and 356long-term potentiation 54neuronal survival 257
errorless learning 97–8aphasia 439dementia 515–17, 521–2executive dysfunction 482
erythropoietin 424, 539escaped fibers, during muscle
reinnervation 474–5,478–9
essential tremor (ET) 567, 569ethical issues, implanted neural
prostheses 550EVA-1 (epithelial V-like antigen)
305evoked potentialsdisorders of consciousness
390–1see also motor evoked
potentials; somatosensoryevoked potentials
excitability, brainafter stroke 197–9noninvasive brain stimulation
inducing 246excitatory postsynaptic potentials
(EPSP) 36EXCITE trial 335, 337, 606–7excitotoxicitycerebral palsy 214neurodegenerative diseases
261–2executive dysfunction 489–96clinical features 489–91noninvasive brain stimulation
227rehabilitation 492–6
executive function 489cognitive theories 491–2virtual reality applications
205–7exerciseamyotrophic lateral sclerosis
657brain reserve capacity and 509functional electrical
stimulation 125, 630induced hypotension 422inflammatory myopathies
665–6physiology of acute 367–8, 370
Index
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exercise capacity 367–74factors affecting 368–9measurement 368–9neurological disorders 369–72see also VO2 max
exercise trainingcritical illness myopathy 666energy costs of walking after
378genetic influences on response
28long-term adaptations 372in neurological disorders372–5
modes 372–3multiple sclerosis 373, 375,
646–7Parkinson’s disease 375, 570post-polio syndrome 659postural tachycardia syndrome
426recommendations 378stroke 9–10, 373, 375early phase 268–71
timing of onset 373see also treadmill training
expanded disability status scale(EDSS), Kurtzke 643
experience-dependent plasticitycerebral cortex 103–6disorders of consciousness 394genetic factors 29memory consolidation 31ocular dominance 160post-injury 108–9stroke recovery 12–15see also activity-dependent
plasticity, learningexperimental allergic
encephalomyelitis (EAE)axonal degeneration 278Na+ channel expression 461–2neuroprotection of axons 466stem cell therapies 587–8
experimental spinal cord injury232–3, 529, 531
bilateral staggered hemisection175–6, 182
clinical translation issues247–9
complete section see spinalcord transection
incomplete 169–76, 180locomotor recovery 161,
166–84, 349cat models 166–71, 348interventions stimulating180–4, 536–7
kinematic analysis seeunder kinematic analysis
mouse models 176–7olfactory ensheathing celltransplants 505
outcome measures 530,532–4
rat models 171–6spinal plasticity underlying177–80
locomotor training 61, 170–1,180–1, 184
lower vertebrates 330–4models and outcomes 530, 532nonhuman primates 537, 248sensorimotor outcome
assessment 529–37unilateral hemisection 532changes in 5-HT neurons179
changes in descendingpathways 179
locomotor recovery 169–71,173, 177
experimental study designs 2experimental treatmentsclinical trials see clinical trialscriteria for initiating human
studies 231–2expiratory muscle strength
training (EMST),Parkinson’s disease 574
explicit motor learning strategies97–8
extinction 160chronic musculoskeletal pain
291, 294–5extracellular matrix (ECM)effects of rehabilitation on 161injured nervous system 157–9,
243normal/uninjured nervous
system 155–7as therapeutic target, in spinal
cord injury 159–60, 244extracellular matrix (ECM)
moleculesaxon guidance cues 303–4inhibiting axon regeneration
243, 376–86secreted after stroke 201–3see also chondroitin sulfate
proteoglycansextubation 267eye movements, role in balance
359–60eye patches, neglect 468eyeblink conditioning 25–6,
29–30EyeToy, Sony PlayStation 200,
202, 209
F-actin (filamentous actin)301–2, 307–8
FAAST (flexible action andarticulated skeletontoolkit) 202
facial nerve injury,electrodiagnostic testing81–2
facilitated communication (FC)227
facilitation (neural) 36Ca2+-dependent mechanisms
41–2intermediate-term, in Aplysia
68long-term (LTF), in Aplysia
66–8quantal mechanisms 38synapse specificity 44–5vs. long-term potentiation 51see also sensitization
facilitation site models 41–2factorial study designs 235falls 105carotid sinus hypersensitivity
425fear of 110, 112prevention 112–15, 151–2Parkinson’s disease 572–3
traumatic brain injury 535vestibular dysfunction 363–4
familiar auditory sensorytraining task (FAST) 394
familycaregivers, dementia 523,
525–8epilepsy patients 559, 562nursing assistant interactions,
dementia 524support, disorders of
consciousness 393, 398fampridine see 4-aminopyridineFas–Fas ligand, neuronal death
257fatiguemultiple sclerosis 641traumatic brain injury 544
fearof falling 110, 112ictal 554–5
fear conditioning 26–7, 30chondroitinase ABC therapy
160feedbackelectrical 528facilitating sensory training
305gait training 66neglect rehabilitation 468,
471see also biofeedback, visual
feedbackfeeding behavior, Aplysia
69–70female reproductive dysfunction
430fetal neural precursor cells,
human, spinal cordtransplants 441
fetal spinal cord (FSC)transplants, spinal cordinjury 436–7
fetal tissue transplants, spinalcord injury 436–7
fibrinogen 344, 378
fibroblast growth factor-2(FGF-2) see basicfibroblast growth factor
fibroblast growth factors (FGFs),synaptogenesis 322
fibroblastsgeneration of neurons from
448olfactory ensheathing cell
populations 504fibromyalgia 290, 295fibronectin 158–9, 383fibrous scar 158–9Fick equation 367–8filopodiadendritic 318growth cone 301–2, 422–3
Finetech–Brindley (Vocare)bladder control system129–30, 428–9, 543
finger extension, post-stroke334, 596
finger-tapping task 85fingolimod 640fishadult neurogenesis 284–5axonal regeneration 118–19,
330–2retinotectal map development
114–15fitness, physical 269–70
see also exercise capacityflecainide, axonal
neuroprotection 466flexion-withdrawal reflexes 83,
535development 85–6
Flk1 see vascular endothelialgrowth factor receptor 2
floor effects, outcome measures41
Florida apraxia battery (FAB)456
fludrocortisone 422–3fluoxetine 29, 320fMRI see functional magnetic
resonance imagingfocal hand dystonia see hand
dystonia, focalFood and Drug Administration
(FDA) 449food preparation, assistive
devices 158food reaching and grasping tasks
534–6foot dropfunctional electrical
stimulation 125, 606motor neuroprostheses
256–8neural prostheses 547–8
footprint analysis 533–5foreign body response, implanted
neuroprostheses557–8
Index
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forelimbamputations, somatosensory
reorganization 77injuries, motor cortex
plasticity 106motor recovery measures
534–5musculature, cortical
representations 99–100see also upper extremity
4.1N protein 55fractalkine (CX3CL1) 396fractalkine receptor (CX3CL1R)
396fragile-X syndrome 58free radicals 261–2Freehand System® 127–9,
258–9, 546, 630Frenchay arm test (FAT) 313frequency of rapid alternating
movements, of maximalamplitude 313
frequenin (NCS-1) 42Fresnel prisms 501frogsregeneration of retinal
ganglion cell axons118–19, 306, 334
retinal regeneration 333–4retinotectal map development
114–15spinal cord regeneration 333
frontal lobeexecutive function 489lesionsapraxia 450dysexecutive syndrome489–91
memory functions 31–2motor functions 53, 102–3
frontal lobe epilepsy 560frontotemporal dementia
260–1frontotemporal dementia with
parkinsonism linkedto chromosome 17(FTDP-17) 394
Fugl-Meyer assessment of motorperformance (FMA)
arm subscale (FM-A) 41, 338leg subscale (FM-L) 40–1
functional activities, virtualreality applications 207–8
functional assessment,sensorimotorsee sensorimotor functionassessment
functional connectivity analysis,aphasia 443
functional electrical stimulation(FES) 120–30, 555
applications 123–30, 546–8critical illness myopathy 666mechanisms of action 120–1motor neuroprostheses 253–6
spinal cord injury 125–30,630–1
functional recovery research125–6
functional uses 126–30therapeutic exercise 125
spinal muscular atrophy 658stimulation parameters 122–3stroke rehabilitation 124–5,
547–8, 605–6system components 121–2, 128see also neural prostheses
functional independencemeasure (FIM) 67
pattern of recovery after stroke591–3
predictive value in stroke 594functional magnetic resonance
imaging (fMRI) 84aphasia rehabilitation 442–3blindness 129–30stroke 13–14, 87–9predicting recovery 44–5,90–1
tactile perception 142–4transcranial magnetic
stimulation (TMS) with224
traumatic brain injury 537functional neuroimagingAlzheimer’s disease 510aphasia rehabilitation 442–3blindnessauditory spatial function127–30
visual cortical function 144disorders of consciousness 390praxis control 454stroke/focal brain injury 84–92cerebral reorganization13–14, 85–9, 196–7
choice of motor task 84–5predicting recovery 43–5,90–1
therapeutic interventions 90techniques 84transcranial magnetic
stimulation (TMS) with224
visual cortical function andtactile perception 142
see also specific modalitiesfunctional neuromuscular
stimulation (FNS)see functional electricalstimulation
functional reach test 110functional residual capacity
(FRC) 266
GABA (γ-aminobutyric acid)effects of spinal cord injury
177–8retinotectal pathway
development 117–18
signaling after stroke 197–9somatosensory system injury
76GABAA receptor α-5 inverse
agonists, stroke recoveryand 198
GABAA receptors, spinal cordinjury 178
GABAergic neurons,replacement after spinalcord injury 446
gabapentin 428, 552–3, 623gaitcompensatory strategies after
stroke 15–16, 602dynamic stability during
see dynamic posturalstability during gait
speed see walking speedsee also locomotion; walking
gait analysis 62–3clinical relevance 42–3, 350electromyography (EMG) 62,
81, 343gait disorders 63–4, 343–51assistive technology 151–2hemiparesis 63–4, 346–8, 604paraparesis 64Parkinson’s disease 344–5spastic 345–8
gait trainer device 65, 190gait training 64–6applying learning theories
100–3approaches 64attentional focus and 102cues and feedback 66electromechanical and robotic-
assisted 190–5advantages 190–2devices available 190disadvantages 192multiple sclerosis 647subgroup analysis 193–4systematic review ofevidence 192–5
home based 66implicit 102neural repair strategies and 67Parkinson’s disease 66, 571–2pulse therapies 66rationale 61–2, 349spinal cord injury 184, 348–50rationale 61–2
stroke 190–5, 271, 348task-oriented 64–6variability of practice 102–3virtual reality applications 210see also treadmill training
games, computerexercise training 372rehabilitation robotics with
181–2gaming platforms, virtual reality
systems using 202
γ-aminobutyric acid see GABAγ-retrovirus gene vectors 515,
517gangliosides, myelin-associated
glycoprotein interactions352
GAP-43 (growth-associatedprotein-43) 10, 332, 424
gastroesophageal reflux 264gastrointestinal dysfunction
428–9spinal cord injury 429, 621see also bowel function
gastroparesis 429GAT-3/4 198gaze stabilityfunctional measurements 360role in balance control 359–60vestibular exercises 361
gene therapy 514–22ex vivo 514–15in vivo 514–15spinal cord injury 247, 518,
521trophic factor delivery 514–22limitations 522methodologies 514–17specific neurologicaldiseases 517–22
vector selection 516–17vectors 515–17
genetic factors 25–30attention to task 27–8axon regeneration in
adulthood 243depression 28learning 27less studied 29–30neuroplasticity 25–7therapeutic responses 28–9traumatic brain injury
outcome 537–8genitourinary evaluation, spinal
cord injury 621germinal matrix hemorrhage,
perinatal 211Geron Corporation 442, 449ghrelin 429Ginkgo biloba 480Glasgow coma scale (GCS) 389glatiramer acetate 640glial cells 367–73axon regeneration role 371–3lower vertebrates 333–4
CNS inflammation 392–3diversity, development and
functions 367–71Na+ channel transfer to axons
462–4regulation of synaptogenesis
322types 367, 392see also astrocytes; microglia;
oligodendrocyte(s);Schwann cells
Index
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glial-derived neurotrophic factor(GDNF)
amyotrophic lateral sclerosisgene therapy 520
Huntington’s disease genetherapy 520
Parkinson’s disease genetherapy 519
peripheral axon regenerationand 403–4
peripheral neuron survival and402
spinal cord injurygene therapy 521with Schwann cell grafts 501
stroke gene therapy 522therapeutic potential 259
glial fibrillary acidic protein(GFAP), traumatic braininjury 536
glial-restricted precursors (GRP)differentiation from
neuroepithelial cells 437isolation and properties 438–9spinal cord transplants 380,
441–7, 449glial scar 158–9, 376–86around implanted devices
557–8methods of studying 560–1strategies for minimizing559–60
cellular environment 379–81dystrophic axons 376–8formation 157–8, 360, 371,
378–9growth-inhibiting molecules
381–3growth-promoting molecules
383–4inhibition of axon
regeneration 360, 376–86molecular environment 381–4penumbra vs. core 384potential interventions 384–5protective role 376spinal cord injury 157–9
gliosis, reactive see astrogliosis,reactive
Gln-Tyr-Asn-Ala-Asp(QYNAD) peptide 460
globus pallidus internus (GPi)stimulation
dystonia 577–8Parkinson’s disease 543–4,
568–9glutamatecerebral palsy 212–14control of locomotion 182denervation supersensitivity 3enhanced uptake, long-term
sensitization 66long-term potentiation 52–5neurodegenerative diseases
262
stroke recovery and 198–9glutamate receptors (GluR)cerebral palsy 214long-term depression 55–7long-term potentiation 52–5metaplasticity 57neurodegenerative diseases
262role in locomotion 182subtypes 52–3synaptogenesis 319–20see also specific subtypes
glycine, spinal cord injury 177–8glycogen synthase kinase (GSK)
420glycoprotein 130 (gp130) 416–17glycosaminoglycans (GAGs) 156goal-attainment scaling 313goal-directed behavior 495–6goal selection and goal neglect
theory 492goldfish, neural regeneration
284–5, 331–2grab bars 151Gram-positive organisms,
cerebral palsypathogenesis 214
granular degeneration ofcytoskeleton, Walleriandegeneration 275
granule cells, hippocampal,newly generated 289–90
granulocyte colony-stimulatingfactor (G-CSF), stroketherapy 248
graspingmotor compensations after
stroke 600–2strategy, balance control 109systems restoring, in
tetraplegia 127–9tasks, animal models 534–6virtual reality applications
208, 210grating orientation tactile
discrimination task141–2
grid-walking test 533, 536GRIP1 protein 57grooming, assistive technology
155grooming test 534–5group B streptococcus (GBS),
cerebral palsypathogenesis 214
growth, axon see axon growthgrowth-associated proteins 424
see also GAP-43growth cones 301–2calcium and motility 422cytoskeleton 301–2, 422–3regulation 307–8
dystrophic see dystrophicgrowth cones
guidance see axon guidance
local protein synthesis 424modulating response to
guidance cues 308regenerating axons 423, 425
growth factorsdistal axonal degeneration 277neural induction of
pluripotent stem cells 439neural precursor cell responses
287–8neural stem cell differentiation
437–8therapeutic studies 248, 245see also neurotrophic factors;
specific factorsgrowth hormone deficiency 393,
541guanfacine 469guidelines, clinical practice 70Guillain–Barré syndrome (GBS)
660–2electrodiagnostic testing 79, 81exercise capacity 370exercise training 375pathophysiology 459–60rehabilitation and outcome
660–2therapy in acute phase 660–1
gunshot wounds, head 385–6gustatory sweating 431
H-reflexesadaptive changes in normal life
86–8operant conditioning studies
88–91therapeutic applications of
conditioning 92H200 system see Ness H200
systemhabituation 23, 63neural mechanisms in Aplysia
64–5sensory, balance rehabilitation
112–13hand dystonia, focal 555, 576rehabilitation 578see also writer’s cramp
hand functionneuroprostheses, spinal cord
injury 127–9, 546–7strokechanging somatosensoryinput 246
compensatory strategies 16,600–2
functional electricalstimulation 124
predicting recovery 595–7virtual reality systems 208–10
hand function survey 300hand grip tasks, functional
neuroimaging 85handrails 151–2haptic discrimination
blindness 141neural basis of visual
involvement 143–4visual cortical involvement 142see also tactile perception
haptic feedback, virtual realitysystems 200–1
harnesses, for gait training 65Harrison, Ross Granville 301head and neck supports,
wheelchair 171–2head injury see traumatic brain
injuryhead mounted displays (HMD),
virtual reality systems199–201
head movementsmeasuring gaze stability
during 360vestibular control 108, 357–9
head-related transfer function(HRTF) 126
headachechronic tension 289post-traumatic 544see also migraine
hearing assessment, disorders ofconsciousness 395
hearing impairment 132–5auditory prostheses 544–5cochlear implants 133, 544–5cortical reorganization in
congenital 132during life span 132–3tinnitus and 134–5
heart diseaseexercise capacity and 369–71stroke patients 263, 268
heart rate (HR)during exercise 368training-induced changes 372VO2 max estimation 368
heat shock factors (HSFs) 264–6heat shock proteins (HSPs)
264–7heat stress response (HSR) 264–6Hebbian plasticity 50cortical motor systems 104development of visual
connections 116–18long-term potentiation 51–2NMDA receptor activation 53somatosensory system 76–7see also activity-dependent
plasticityhedgehog proteins 306hemi-cord syndrome
(Brown–Séquardsyndrome) 169, 617
hemineglect see neglect,unilateral
hemiplegia/hemiparesisafter temporal lobectomy
562–3anosognosia for 470
Index
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
hemiplegia/hemiparesis (cont.)assistive technology 152compensatory movements
15–16, 600–1corticospinal tract lesions 56functional electrical
stimulation 124–5gait disorder 63–4, 346–8peripheral nerve stimulation
137–8shoulder pain see shoulder
pain, hemiplegicthreshold joint angles 605upper extremity rehabilitation
330–9see also stroke
herbal remedies, memorydysfunction 480
hereditary spastic paraparesis(HSP) 277–8
herpes simplex virus (HSV)vectors 515, 517
heterotopic ossification (HO)543, 622–3
hierarchical substitution,principle of 16
high-load brief stretch (HLBS)315
high resolution perimetry (HRP)503–4
hip strategy, balance control108–9, 114
vestibular loss 357hippocampal formation 50hippocampusadult neurogenesis 288–90induced 292–3medical implications 294
architecture 50–1learning andmemory 25, 28–31long-term depression 55–6long-term potentiation 51–5neural precursor cells 285slice preparation 50–1
hippotherapy, multiple sclerosis647–8
HIV see humanimmunodeficiency virus
Holmes–Adie pupil 419, 431home automation systems 152home-based interventions,
dementia 527–8home environmentcontrol devices 150, 152falls prevention 114–15
homeostatic plasticity 2–3, 11–12horizontal fibers, motor cortex 104horizontal ladder test 533–4Horner’s syndrome 419hospital stay, duration, effects of
clinical pathways 72–35-HT see serotonin5-HTTLPR (serotonin-
transporter-linkedpolymorphic region) 28
human immunodeficiency virus(HIV)-associatedperipheral neuropathy 277
human immunodeficiencyvirus (HIV)-relatedmyopathy 80
huntingtin (Htt) 260, 264, 268Huntington’s disease (HD)apraxia 448, 457cell death mechanisms 259–61,
268gene therapy 518–20mitochondrial dysfunction 264rehabilitation 579
hyaluronic acid 243hyaluronidase 157hydrocephalus 393, 541–25-hydroxytryptamine
see serotonin25-hydroxyvitamin D (25-OHD)
deficiency, Parkinson’sdisease 573
hyperacuity task, tactile see tactilehyperacuity task
hypercalcemia, immobilization624
hyperhidrosis 431hypertensionautonomic disorders 426–7supine 427
hypertensive subcorticalarterioscleroticencephalopathy 569
hyperthermia 431hypopituitarism, post-traumatic
393, 541hypotensionorthostatic (postural)
see orthostatichypotension
postprandial 422, 424hypothalamus, thermoregulation
430hypothermiaautonomic dysfunction 431therapeutic, traumatic brain
injury 538–9hypoxic-ischemic
encephalopathy 212, 214
IBB forelimb dexterity test 534,536
iceberg effect 76ICF see International
Classification ofFunctioning, Disabilityand Health
ideomotor apraxia test (IAT) 456imagery techniquesParkinson’s disease 571phantom limb pain 294unilateral neglect 469
imaging see neuroimagingimmersion, virtual reality
systems 198–9
immune response, activation 393impedance mismatch/matching,
demyelinated axons464–5
implantable electrodes 121–2,255
see also microelectrodes,implanted
implantable neuroprosthesessee neural prostheses
implanted pulse generator (IPG)122
implicit motor learning strategies97–8, 102
importins 416impulse reflection 460IN-1 monoclonal antibody 340,
350, 355see also Nogo-A antibodies
inclusion body myositis (IBM)665–6
Independence 3000 IBOTTransporter 166–7
Independent Data MonitoringCommittee (IDMC) 235
induced pluripotent stem (iPS)cells
directed differentiation 437neural induction 439production and properties 439spinal cord transplants 445
infants, language and speechdevelopment 131
infections, maternal intrauterine212, 214–15
inferential study designs 2inferior parietal lobule (IPL),
blind humans 129–30inflammatory myopathies 80,
665–6inflammatory response 392–7α-synucleinopathies 394Alzheimer’s disease 393–4amyotrophic lateral sclerosis
395–6axon regeneration and 416–18cerebral palsy 214–15glial cells 392–3glial scar formation 378–9implanted neuroprostheses
542–3, 557–8microelectrode insertion
procedure 557microglial signaling in
resolution 396–7Parkinson’s disease 394signaling mechanisms 393–4tauopathies 394
inhibition (neural)after stroke 198impaired, in dystonia 576injured spinal cord 177–8non-invasive brain stimulation
inducing 246–7see also disinhibition
inhibitory postsynapticpotentials (IPSP) 36
inpatient rehabilitation facility(IRF) 286
instrumental activities of dailyliving (IADL), assistivedevices 157–8
instrumental learning see operantconditioning
insular cortex, changes afterstroke 85
insulin-like growth factor-1(IGF-1)
after stroke 201, 204gene therapy, amyotrophic
lateral sclerosis 520neural precursor cell responses
287, 290integrated care pathways
see clinical pathwaysintegrins 304, 358intellectual disability 58intensity of therapyaphasia 443–4disorders of consciousness
394stroke 9, 282–4, 335–6,
604intensive care unit (ICU) 262,
264–8intensive language action
therapies 440interdisciplinary model 281interferon-β-1a 640interferon-β-1b 640interferon-γ (IFN-γ) 378–9interhemispheric balance effect,
noninvasive brainstimulation 223
interhemispheric inhibition(IHI) 142–3
interhemispheric rivalry concept144–5
interim analysis 235interleukin-1 (IL-1) 215, 378,
538interleukin-1 receptor antagonist
(IL-1ra) 538interleukin-6 (IL-6) 416, 538interleukin gene polymorphisms
28, 538intermediate-term sensitization
and facilitation, inAplysia 68
intermittent catheterization (IC),spinal cord injury 621,623
internal capsulecorticospinal tract axons 55lesions, post-stroke hand
function and 596–7International Campaign for
Cures of Spinal CordInjury Paralysis (ICCP)449
Index
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www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
International Classification ofFunctioning, Disabilityand Health (ICF) 278–9
multiple sclerosis 643outcome measures and 35,
236–7recovery and compensation
599–600stroke recovery and 7, 585–6
international conference onharmonization (ICH) 234
International Society for StemCell Research (ISSCR)449
international standards for theneurological classificationof spinal cord injury(ISNCSCI) 237–8, 617
interneurons (INs)Aplysia reflexes 64spinal, locomotor control 167,
169, 173interpositus nucleus (IP),
cerebellar 25–6interpretability, outcome
measures 38InterQual guidelines 286interrater reliability 36InterStim system, Medtronic 543intracortical brain–computer
interfaces (BCIs) 549,567, 569–70
advantages 577–9direct speech 579future engineering efforts
581–2motor 579–81problems of long-term use
556, 581–2tetraplegia 578–9see also microelectrodes,
implantedintracortical microstimulation
(ICMS) 101, 104–5intracranial brain–computer
interfaces (BCIs) 577–82future engineering efforts 581–2signal sources and electrode
types 577–9see also electro
corticography (ECoG)-based brain–computerinterfaces, intracorticalbrain–computerinterfaces
intramuscular electrodes 121–2,255
intraneural electrodes 255Intrarater reliability 36intrauterine infections, maternal
212, 214–15intravenous immunoglobulin
(IVIg) 660, 662–4intraventricular hemorrhage,
perinatal 211
invertebrateslearning 23nervous system regeneration
329–30see also Aplysia californica;
Caenorhabditis elegans;Drosophila melanogaster
ion channels, myelinated axons457–9
iPads, communication apps221–3, 225
IRE1 266IREX (Interactive
Rehabilitation Exercise)system 200, 209
ischemia, delayed neuronaldeath 6
ischemic nerve block, motorcortical plasticity 245
IST-12 upper extremityneuroprosthesis 547
item response theory (IRT)38–9
Jackson, Hughlings 439JAK-STAT pathway, axon
regeneration 417, 421Jebsen–Taylor test (JTT) of hand
function 245, 300jewelry 155JNK pathway 257, 401–2The Jogger 153Jun 422
kainate receptors (KAR) 52Kalman filter 580Kdr see vascular endothelial
growth factor receptor 2Kinect gaming system, Microsoft
200, 202kinematic analysisdeforming spastic paresis 314experimental spinal cord
injury 533cats 166, 168–70mice 176–7rats 171–4
motor compensation 605movements in virtual vs. real
environments 210kinematic impairment index
(KIM) 338–9kinesin 422knowledge, explicit vs. implicit
97–8Kruppel-like factors (KLFs) 414
L-DOPA see levodopaL-DOPS (L-threo-3-4-
dihydroxyphenylserine)424
L1 protein (L1CAM)axon guidance 305–6axon regeneration 332, 415,
425
L300 system, Ness 256Lambert–Eaton myasthenic
syndrome (LEMS) 80,664–5
lamellipodia, growth cone 301–2,422–3
lamininsafter spinal cord injury 158–9axon guidance 303–4, 308CSPG interactions 381–2glial scar 383receptors 304structure 303
lamotrigine 466, 552–3lampreyheterogeneity in neuronal
regenerative ability 331,415
neurofilaments in regeneratingaxons 331, 423
spinal cord regeneration 330–1Landau–Kleffner syndrome 550languageacquisition 129–31automatic-voluntary
dissociation 439disorders, acquired 437function after temporal
lobectomy 561loss vs. dysfunction 438–9post-stroke recoverynoninvasive brainstimulation 146–7, 227–9,247–8
pharmacotherapy 242–4training and practice effects241
processingholistic vs. localizationistapproaches 437–8
multisystemic interactions440–1
visual cortex in blindness147
see also aphasiaLAR (leukocyte antigen-related)
proteins 309, 322, 381–2Lashley, Karl 28, 107lateral funiculus, locomotor
control in rats 172–3lateral occipital complex (LOC)haptic shape perception 143–4normal tactile perception
142–3tactile perception in blindness
145laterality index (LI), predicting
stroke recovery 44–5Laufband therapy see body
weight-supportedtreadmill training
learned non-useaphasia 439dysphagia 411–12traumatic brain injury 544
learningin Alzheimer’s disease 510,
518–22associative see associative
learningcellular and molecular
mechanisms 22–32, 58,63–71
Aplysia 63–71extracellular matrix 157
in cognitive impairment515–17
in dementia 517–22differential 99–100elementary forms 63enhanced, memory deficits
481–2errorless see errorless learningexplicit vs. implicit 97–8, 102genetic influences 27instrumental see operant
conditioningmodulating chronic pain
290–1motor see motor learningnonassociative
see nonassociativelearning
probabilistic 24rehabilitation and 71sensorimotor or cognitive
skills 23–4sensory retraining and 303,
305–6stimulus–response (S–R) 24stroke recovery and 197–9transfer, facilitating 306see also conditioning, memory
learning theoriesaphasia rehabilitation 439applied to gait training 100–3dementia rehabilitation
515–17Lee Silverman voice therapy
(LSVT), Parkinson’sdisease 573–4
leeches, axon regeneration329–30
leisure activitiesassistive devices 158virtual reality applications 208
Lennox–Gastaut syndrome 560lentivirus gene vectors 515, 517leucine-rich repeat kinase 2
(LRRK2) 260, 395leucine-rich repeat
transmembrane proteins(LRRTMs) 321–2
leukemia inhibitory factor (LIF)417
levodopa (L-DOPA)effects on locomotor activity
168, 183impact on motor training 320multiple system atrophy 424
Index
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levodopa (L-DOPA) (cont.)Parkinson’s disease 567–8stroke rehabilitation 243–4
Lewy bodies 260, 395dementia with (DLB) 569
Liepmann, H. 447Life-H test 42light stimulationretinotectal pathway
development and 117–18retinotectal pathway
regeneration and 119LILRB2 (leukocyte
immunoglobulin-likereceptor B2) 353
limbic system, role in tinnitus134–5
limits of (postural) stability 105–7assessment 110treatment for reduced 112
lineage-restricted progenitors(or precursors) 437
isolation and properties 438–9terminology 284, 435see also glial-restricted
precursors, neuronal-restricted precursors
linear discriminant analysis(LDA) 581
linear summation model,facilitation 41
Lingo1 204, 309, 342, 353link protein 157lipopolysaccharide (LPS) 214liposomes 515–16lizardsadult neurogenesis 284axon regeneration 119, 334
local field potentials (LFPs),brain–computerinterfaces 567, 570
locked-in syndrome 262, 387–8locomotioncentral pattern generator
see central patterngenerator (CPG),locomotor
control in humans 343–4, 346,348
energy expenditure during374–8
spinal cord injury seeunder experimentalspinal cord injury; spinalcord injury
see also gait; treadmilllocomotion; walking
locomotor disorders see gaitdisorders
locomotor experience appliedpost-stroke (LEAPS)trial 65
locomotor trainingexperimental spinal cord injury
61, 170–1, 180–1, 184, 348
humans see gait traininglocus ceruleus cell transplants,
spinal cord injury 437Lokomat system 65, 190, 210long-term depression (LTD)
55–8cerebellar 26, 56–7extracellular matrix
components and 157hippocampal 55–6learning and memory and 58limitations of studies
investigating 57–8as mechanism of human
neuroplasticity 241metaplasticity and 57neuropathological insights 58
long-term facilitation (LTF),in Aplysia 66
long-term memory see memory,long-term
long-term potentiation (LTP)50–5, 57–8
classical conditioning inAplysia and 68–9
expression, mechanisms 53–5extracellular matrix
components and 157functional electrical
stimulation and 120–1glutamate and glutamate
receptors 52–5Hebbian properties 51–2heterosynaptic 51homosynaptic 51induction, mechanisms 53–4learning and memory links 58limitations of molecular
studies 57–8as mechanism of human
neuroplasticity 241–2metaplasticity and 57neuropathological insights 58newly generated hippocampal
granule neurons 289pathway, neuron and synapse
specificity 51relationship with long-term
depression 56stroke recovery and 197
long-term sensitization, Aplysia66–8
Lou Gehrig’s diseasesee amyotrophic lateralsclerosis
lower extremity, botulinum toxininjections 319
lower extremity functionassessment 313–14, 349–50paraplegia 627–8stroke 604predictive value 595
see also standing; walkinglower extremity rehabilitationdeforming spastic paresis 318
early onset 271functional electrical
stimulation 126–7, 630motor neuroprostheses 256–9neural prosthetic systems
547–8robotics, orthotics, and
prosthetics 190–5stroke 604–7virtual reality applications 210see also gait training
lower motor neuron lesions,electrodiagnostic testing78–80
LRRK2 (leucine-rich repeatkinase 2) 260, 395
LRRTM (leucine-rich repeattransmembrane) proteins321–2
LTD see long-term depressionLTP see long-term potentiationlumbar spinal cordlocomotion in cats 168–9locomotion in rats 171–2, 175
lumbar support, wheelchairs171
lysosomes 267
M1 see primary motor cortexmacroautophagy 267
see also autophagymacrophagesglial scar formation 378, 381regulation of activity 393responses to implanted devices
557–8zymosan-induced activation
385see also microglia
MAG see myelin-associatedglycoprotein
magnetic resonance imaging(MRI)
functional see functionalmagnetic resonanceimaging
parkinsonism 568spinal cord injury 619–20traumatic brain injury 536–7see also diffusion tensor
imagingmagnetic resonance spectroscopy
(MRS), traumatic braininjury 537
magnetoencephalography(MEG) 84
MAGUK (membrane-associatedguanylate kinase) familyproteins 55
male sexual dysfunction 429–30Maloney murine leukemia virus
(MLV) 515mammalian target of rapamycin
see mTORmanual dexterity task 105–6
MAPK (mitogen-activatedprotein kinase), long-term sensitization 67
maternal intrauterine infections212, 214–15
matrix metalloproteinases(MMPs) 157–8, 383–4
maximal frequency of rapidalternating movements313
maximal oxygen consumptionsee VO2 max
mechanical in-exsufflator(MI-E) 622
mechanical ventilation 265–7amyotrophic lateral sclerosis
657Guillain–Barré syndrome 661weaning from 267–8
mechanosensitivity, increased460
medial geniculate nucleus, role intinnitus 134
medial temporal lobe, learningand memory 24, 28–9
median nerve section,somatosensory systemchanges 78
median nerve stimulationcortical effects 137paretic hand in stroke 137–8
medical alert tags 153medical model 280Medicarefunding of communication
devices 223see also Centers for Medicare
and Medicaid Servicesmedication reminders 153,
157–8, 484medications, impact on motor
recovery 319–20Medtronic InterStim system 543medulla, parapyramidal region
(PPR), control oflocomotion 172, 182
melodic intonation therapy(MIT) 440, 442
memantine 244, 480memory 478–9associative 24–6cellular mechanisms 22–32, 58consolidation 27–8declarative (explicit) 28–32,
479animal studies 29–31human observations 28–9
extracellular matrix function157
hippocampal neurogenesisand 290
intermediate-term, in Aplysia68
long-term 478–9categories 22–3
Index
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mechanisms in Aplysia66–8
nonassociative 23nondeclarative (implicit) 23–8priming 24procedural 23–4processing in Alzheimer’s
disease 510prospective 479, 484, 491reconsolidation 31semantic, neocortical storage
31–2somatosensory pain 290–1stroke recovery mechanisms
and 197–9working (short-term)
see working memorysee also learning
memory aids, external 153–4,483–5
memory awareness ratingscale–adjusted (MARSA)513–14
memory books, personalized524
memory dysfunction 478–85after temporal lobectomy
560–1compensatory strategies
481–5epilepsy 558frontal lobe lesions 490–1rehabilitation strategies 478restitution-oriented therapies
479–81traumatic brain injury 540–1virtual reality applications
204–5memory glasses 484memory training 480–1dementia 518–20, 526healthy elderly 518
mental health problemssee psychiatric disorders
mesencephalic locomotor region(MLR) 169, 175
mesenchymal stem cells (MSC)448, 587, 591
spinal cord transplants 589transplants in multiple
sclerosis 587–8transplants in stroke 590–1
mesial temporal sclerosis (MTS)559–60
metabolic equivalents (METs)369–70
training effects 372, 375metabolic syndrome 369metabotropic glutamate
receptors (mGluRs) 52–3long-term depression 56–7metaplasticity 57
metaplasticity 57critical period of, after stroke
206
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-inducedparkinsonism 260
methylphenidatedementia 528disorders of consciousness
393, 539genetic influences on response
28post-stroke depression 608traumatic brain injury 539–40
methylprednisolone 502, 629–30,639–40
microautophagy 267microelectrodes, implanted
556–8brain tissue responses 542–3,
557–9dexamethasone-releasing 560insertion-mediated damage
555–7intracranial brain–computer
interfaces 577–9materials 556recording by 541–2, 556reducing stiffness 559–60see also electrodes
microglia 367Alzheimer’s disease 393–4cerebral palsy 212–15implanted device responses
542, 557–9inflammatory response 392–4Parkinson’s disease 394–5regulation of activity 393role in axonal regeneration
372–3signaling in neuroprotection
396–7microtubules (MT)axonal transport 422growth cone 301–2, 423regenerating axons 423–4
microwave ovens 158micturition control see bladder
controlmicturition syncope 425middle occipital gyrus (MOG),
blindness 129–30middle temporal (MT) complexcross-modal motion perception
in blindness 146–7normal cross-modal motion
perception 142midodrine 423migraine 293mild cognitive impairment
(MCI)deep brain stimulation 528virtual reality applications 205see also dementia
military traumatic brain injury 535Milliman Care guidelines 286mind mapping technique 482
minimal clinically importantdifference (MCID)38, 41, 236
minimal detectable change(MCD) 41
minimally conscious state (MCS)263, 387–8
diagnosis of emergence 389emergence and prognosis 398experience of pain 393incidence and prevalence 388
minimization principle 603minocycline, microelectrode
insertion and 560mirror therapy 148, 294mitochondriaaxonal degeneration and 277dysfunction in
neurodegenerativediseases 262–4
fission and fusion 262–3neuronal cell death and 257–8,
263presynapticCa2+ extrusion 37, 40, 42–3Ca2+ uptake 37, 40, 44regulation of energy supply44
mitofusin-1 (Mfn1) 263mitofusin-2 (Mfn2) 263mutations 277
mitogen-activated protein kinase(MAPK), long-termsensitization 67
mitophagy 268mitoxantrone 640mixed reality stroke rehabilitation
system 338–9mnemonics 483mobile electronic devicesassistive technology 157, 159communication apps 221–3,
225memory aids 153, 483–4virtual reality-based
rehabilitation 212see also cell phones,
smartphonesmobility devices 64, 156–7electric powered 165–8see also wheelchairs
mobility impairmentmultiple sclerosis 640–1recovery after stroke 593see also locomotion, motor
impairments, walkingmobility scooters 157, 166mobilizationcritical illness myopathy 666early post-stroke 268–9
modafinil 540, 641Molaison, Henry 28–9Molyneux, William 140monoamine oxidase B inhibitors
568
mossy fibers 26motion sensitivity quotient
(MSQ) 362motor abundance 602–5motor activity log (MAL) 338motor adaptation 8motor brain–computer interfaces
579–81continuous decoders 579–80discrete decoders 580–1
motor compensationafter brain damage 600–2definition 8maladaptive 603–4measurement 605mechanisms 602–5stroke recovery and 15–16, 595
motor controldisrupted, Parkinson’s disease
571voluntary see voluntary motor
controlmotor cortex 99–110adult neurogenesis 292–3functional organization
99–103nomenclature 99–100non-primary areas (NPMAs)
53–5functional organization101–3, 53–5
reorganization after braininjury 55, 85–9
plasticity after deafferentation245
plasticity of motor maps103–9, 13
behavioral experiencemodulating post-injury108–9
experience-dependent103–6
post-injury 106–8post-stroke 106, 108, 196,13–14, 85–9
role in rehabilitation 109–10primary see primary motor
cortexsomatotopic organization 101strokeaxon sprouting 197, 199–200functional changes 106, 108,196
transcranial direct currentstimulation 247–8see also specific areas
motor equivalence 602–3motor evoked potentials (MEPs)
141–3spinal cord injury 618–19stroke 43
motor functioncerebral see cerebral motor
functionsearly rehabilitation 268–71
Index
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www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
motor impairmentsassistive technology 151–2brain–computer interfaces
570–2, 579–81communication devices 224Parkinson’s disease 570–1virtual reality applications
208–10motor learning 95–103Alzheimer’s disease 520attentional focus effects 96–7definition 104Fitts and Posner’s (standard)
model 95–6implicit vs. explicit knowledge
97–8motor cortex plasticity 104noninvasive brain stimulation
and 145principles, rehabilitation study
designs 5–6Schmidt’s schema theory 99theories applied to treadmill
training 100–3variability of practice 98–100context-conditionedvariability 98–9
differential learning 99–100see also motor skill acquisition
motor neglect 465motor neuron disease
see amyotrophic lateralsclerosis
motor neurons/motoneurons(MNs)
activity-dependent plasticity88–90
Aplysia reflexes 64changes after spinal cord
injury 177cortical see cortical
motoneuronsdiseases of 655–60fetal spinal cord transplants 437genetically engineered
progenitors 448neurotrophins and
regeneration after injury402–3
reinnervation of musclesee muscle, reinnervation
replacement, spinal cordinjury 444–5, 448
trophic factors in development255
motor neuroprostheses (MNP)253–9
functional electricalstimulation 253–6
orthotic uses 253principles of action 253systems for restoring limb
function 256–9therapeutic uses 253see also neural prostheses
motor recoverybrain injury, motor cortex
reorganization 52–3, 55compensation and 599–605ICF definitions 599–600importance of spared territory
57medications influencing
319–20spinal cord injury 625nonhuman primates 537preclinical measures 532–5
strokeAMPA receptor signaling198–9
Brunnstrom stages 603–4compensatory strategies15–16
cortical map plasticity13–14
neuroimaging for predicting43–5
noninvasive brainstimulation therapy 247–8
pharmacologicalinterventions 242–3
somatosensory input and244–5
spontaneous 592training and practice effects241
transient regional anesthesia246
upper extremity 333–4see also stroke recovery
traumatic brain injury 544motor restoration, neural
prostheses 546–50motor skill acquisitiondefinition 104motor cortex plasticity 105–6Schmidt’s schema theory 99spinal cord plasticity 91in normal life 86–8operant conditioning studies88–90
see also motor learningmotor systemredundancy and abundance in
602–5voluntary motor control 51–7
motor tasks, functionalneuroimaging 84–5
motor trainingdeforming spastic paresis
316–18impact of systemic
medications 319–20neural consequences 317–18pharmacological interventions
with 242–3role in functional recovery
241timing 318
motor unit recruitment
electrically induced 120, 254strength and 330
motor unit transformation,spastic gait 347
motor vehicle collisions 535, 615Move, Sony PlayStation 202movement disorders 567–79electric powered mobility
devices 167–8see also dystonia, Parkinson’s
diseaseMPTP (1-methyl-4-phenyl-
1,2,3,6-tetrahydro-pyridine)-inducedparkinsonism 260
mTOR (mammalian target ofrapamycin)/mTORpathway
axon regeneration 11, 345,357, 379, 419–20
Huntington’s disease 268Muller glia 368multidisciplinary model
280–1multiple brain trauma/lesions,
noninvasive brainstimulation 225–6
multiple object test 456multiple sclerosis (MS) 637–49clinical features 637diagnosis 637–9exercise capacity 369–70pathogenesis 637axonal degeneration 278, 466conduction abnormalities459
Na+ channel blockingfactors 460
Na+ channel expression461–2, 464
rehabilitation 641–9evaluating outcome 642–3exercise training 373, 375,646–7
multidisciplinary 643–6noninvasive brainstimulation 227
specific modalities 646–9treatment 638–41axonal neuroprotection 466disease-modifying 640potassium channel blockers459, 640–1
relapses 638–40stem cell therapies 586–8,592
symptomatic 640–1multiple sclerosis functional
composite (MSFC) 643multiple system atrophy (MSA)
419, 569diagnosis 422gastrointestinal dysfunction
429orthostatic hypotension 424–5
Parkinson variant (MSA-p) 569supine hypertension 427urinary dysfunction 428
multipotent progenitor cells(multipotent stem cells)
glial scar 380isolation and properties
437–8terminology 283–4, 435transplants, spinal cord injury
440–1see also neural stem cells
MUNC-13 43MUNC-18 321, 323muscarinic receptors 415muscledenervation supersensitivity 2effects of bed rest 265–8effects of stretch 314excessive extrasegmental
co-contraction 312functional electrical
stimulation 120length–force relationship
330–1power 331reinnervation 474–84causes of failure 484damaged/regeneratedmuscle fibers 479–81
endoneurial tubes guiding473–4
escaped fibers 474–5, 478–9guidance of nerve sprouts481
guidance of Schwann cellgrowth 481
molecular mechanisms484–6
reoccupation of synapticsites 481–2
from severed nerve 475–6sprouting of nerve terminal475–6
study methods 474vital imaging 476–9
spastic overactivity 312local treatments 318–19transcranial magneticstimulation and 320
see also spasticitystrength see strengthweakness see weaknesssee also neuromuscular
junctionsmuscle contractures
see contracturesmuscle diseases 80, 665–6muscle fibersdamaged, reinnervation
479–81newly generated, innervation
481muscle-specific tyrosine kinase
(MuSK) 317
Index
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www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
muscle toneassessment 542Parkinson’s disease 345spasticity 346–7
muscular efficiency, walking 376musculoskeletal assessment,
spinal cord injury 620musculoskeletal pain, chronicamyotrophic lateral sclerosis
657behavioral interventions
294–5cortical reorganization 289–91post-polio syndrome 660
music interventions, dementia526–7
musical abilities, acquisition131–2
musician’s cramp 577–8myasthenia gravis (MG) 80, 664myelin 369inhibition of axon
regeneration 339–40peripheral pattern 497
myelin-associated axonal growthinhibitors 243, 309,339–46, 349–54
changes after stroke 203–4genetic studies 342–3molecular identification 340–2other 344–5prototypic see myelin-
associated glycoprotein,Nogo, oligodendrocytemyelin glycoprotein
receptors 341–2, 352–3signaling pathway 309–10,
341–2, 354, 359sprouting vs. regeneration 343–4synaptic plasticity and 345as therapeutic target 354–5,
244–5myelin-associated glycoprotein
(MAG) 203, 341–2,351–60
axon growth inhibition 309,351, 418–19
axonal degeneration anddemyelination 278–9
gene knockout studies 343receptors 341–2, 352–3signaling pathway 204,
309–10, 341–2, 354stroke 204
myelin basic protein (MBP),traumatic brain injury 536
myelinated axons 457action potential conduction
457, 459molecular organization 457–9neuroprotection in
demyelinating diseases 466myelinationby grafted olfactory
ensheathing cells 506–8
see also demyelination,remyelination
myoelectric control, implantedupper extremityneuroprostheses 546–7
Myomo e100 robotic system 178,183–4
myopathies 80, 665–6myosin light chain kinase
(MLCK) 43
N-cadherin (NCAD) 425, 484N-methyl-D-aspartate
see NMDANa+ see sodiumnail care 155nanoparticles, DNA delivery 516Narp 323narrow beam-walking test 533–4nasogastric (NG) tube, stroke
609–10natalizumab 640National Institutes of Health
Stroke Scale (NIHSS)591, 593–4
national joint committee for thecommunication needs ofpersons with disabilities225–6
NCAM see neural cell adhesionmolecule
necroptosis 257necrotic cell death 256need-driven dementia-
compromised behavior(NDB) model 524
neglect, unilateral 463–9anosognosia for 470–1assessment 463–5neuroanatomy 463–4noninvasive brain stimulation
147, 231–2specific modalities 465treatment 465–9, 610–11virtual reality applications
204negotiated equilibrium concept,
spinal cord 90, 92nematodes see Caenorhabditis
elegansneoassociationist approach,
aphasia rehabilitation 440neocortexadult neurogenesis 286, 290,
292–3learning and memory 31–2see also cerebral cortex
neogenin 307, 415neonatal brain injury
see perinatal brain injurynerve conduction studies (NCs)interpretation of report 81lower motor neuron lesions
78–80outcome assessment 81–2
spinal cord injury 619wheelchair users 161see also conduction
nerve cuff electrodes 122, 255nerve electrodes 255nerve growth factor (NGF) 400Alzheimer’s disease gene
therapy 517–19cellular actions 400–1Parkinson’s disease gene
therapy 519peripheral axon regeneration
and 403–4peripheral neuropathy therapy
521receptor 400signal transduction 401spinal axon regeneration and
408, 418spinal cord injury, gene
therapy 502, 521therapeutic studies 385
nerve regeneration see peripheralnerve regeneration
nerve terminal sprouting,Schwann cells mediating475–6
Ness H200 system 124, 129,256
Ness L300 system 256nestin 292NET (norepinephrine
transporter) gene 30netrins 203axon regeneration 310, 344,
358changes after stroke 203developmental axon guidance
304receptors 304synaptogenesis 322–3
network effects, distributed,noninvasive brainstimulation 222–3
networked neuroprosthesis(NNP) 549–50, 130
NeuN 288–9neural cell adhesion molecule
(NCAM) 306, 383, 425neural precursor cells (NPC)adult CNS 283–95endogenous, for cell
replacement 294–5,448–9
generation from pluripotentstem cells 439
glial scar 380heterogeneity 284hippocampal neurogenesis
288–90isolation and culture in vitro
290–1lineage-restricted see lineage-
restricted progenitorsmedical relevance 294–5
methodological issues of invivo study 291–2
motor neuron generation from448
olfactory bulb neurogenesis286–7
populations in adult CNS285–6
terminology 283–4, 435transplantation 285–6, 439–49see also neural stem cells;
neurogenesis, adult;progenitor cells
neural prostheses (biomimetic,implantable) 120, 541–50
brain responses 554–61foreign body/inflammatory542–3, 557–8
insertion-mediated damage555–7
methods of studying 560–1neurodegenerative 556–8plastic 555strategies for addressing559–60
current clinical applications554–5
interface features 541–3recording 541–2, 556stimulation 542
motor restoration 546–50integrated control 548–50lower extremity function547–8
natural volitional control549–50
upper extremity function546–7
neuromodulation throughstimulation 543–4
selectivity–invasivenesstradeoff 556
sensory restoration 544–6social and ethical issues 550spinal cord injury 546–7, 630bladder control 543integrated motor controlsystems 549
standing and walking547–8
upper extremity function546–7
see also functional electricalstimulation, motorneuroprostheses
neural repairstrokeparallelogram concept205–7
principles of 196–207vs. compensation 8–9
neural stem cells (NSCs)adult CNS 283–4, 586–7development and properties
437–9, 591
Index
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
neural stem cells (NSCs) (cont.)generation from pluripotent
stem cells 439multipotent see multipotent
progenitor cellsplanarians 329subgranular zone (type-1 cells)
288terminology 283–4, 435transplantsmemory dysfunction 479multiple sclerosis 586–7spinal cord injury 588–9stroke 590see also stem cell therapies
see also neural precursor cells,pluripotent stem cells
NeuralStem Inc. 441, 450neuregulin 485neurexins 67, 321–3neuro-eye therapy (NeET)
502–5neurobehavioral sequelae,
traumatic brain injury543–4
neurocan 157, 381secretion after stroke 202
NeuroControl Corporation(NCC) 128–30, 546
see also Freehand System®neurodegeneration, at
electrode–brain interface556–9
strategies for minimizing559–60
neurodegenerative diseasesneurogenesis theory 294neuronal dysfunction and
death 258–69noninvasive brain stimulation
226–7, 231, 234neuroelectric blocking factors 460neuroepithelial (NEP) cellsisolation and properties 437–8transplantation studies 441
neurofibrillary tangles (NFTs) 394neurofilaments (NFs)axonal transport 422demyelination and 278distal axonal degeneration 277regenerating axons 331, 423Wallerian degeneration 274
neurogenesis, adult 1, 283–95brain lesions/stroke 204–5consequences of disturbed
293–4defined 284discovery in mammals 285hippocampus 288–90induced in non-neurogenic
regions 292–3lack of constitutive cortical 290medical relevance 294–5methodological aspects of in
vivo studies 291–2
non-mammalian vertebrates284–5
normally non-neurogenicregions 286
olfactory bulb 286–7regions in brain 285–6spinal cord injury 448–9stroke 12–13, 204–5see also neural precursor cells,
neural stem cellsneuroglycan 2 (NG2) 157, 381neuroimagingdisorders of consciousness 390functional see functional
neuroimagingparkinsonism 568spinal cord injury 619–20traumatic brain injury 536–7
neuroligins 67, 321neurolinguistic-cognitive
approach, aphasiarehabilitation 440
neurological assessment, spinalcord injury 617
neuromuscular disorderselectrodiagnostic testing 80rehabilitation 655–66
neuromuscular electricalstimulation (NMES)see functional electricalstimulation
neuromuscular junctions (NMJ)aging animals 480–1developmental remodeling 482diseases of 655, 664–5remodeling after muscle fiber
damage 480Schwann cell role in
remodeling 482Schwann cell territories 482–4Schwann cells and axonal
reoccupation 481–2synapse formation 317
neuron(s)collaterals see collaterals,
neuronalcontralateral, axon sprouting
after stroke 199–201denervated see denervationgrowth inhibitors see axon
growth inhibitorsmolecular signaling of axon
injury 416responses to injury 1–7, 413trophic factors in development
255neuron-intrinsic determinants of
regeneration 413–26developmental loss 414, 425extrinsic modulation 416–19gene expression state 243heterogeneity 414–15intrinsic modulation 419–22site of injury and 415therapeutic modulation 245
vs. extrinsic inhibitors 345neuronal atrophyrescue 415retrograde, after axotomy 4–6transneuronal, after
denervation 3–4neuronal Ca2+ sensor-1 (NCS-1)
42neuronal connectionsectopic, regenerating axons 10effects of injury 1–2reorganization after injury
8–17, 199–201neuronal death 255–69after axotomy 4–6after denervation 4around implanted devices 557,
559strategies for minimizing559–60
autophagic (type 2)see autophagy
cascading 6cytoplasmic (type 3) 256–7delayed, after ischemia 6developmental 255–8molecular regulation 257–8morphological features256–7
mechanisms inneurodegenerativediseases 261–9
neuropathological role 258–61newly generated cells in adult
brain 287, 290nuclear (type 1) 256p75NTF-mediated regulation
257, 401–2types 256–8see also neuronal survival
neuronal replacement therapiesbased on endogenous
precursors 295, 445spinal cord injury 443–8alternative sources of cells448
relay formation 446–8neuronal-restricted precursors
(NRP)differentiation from
neuroepithelial cells 437isolation and properties 438spinal cord transplants 443–4,
446–7, 449neuronal survivalmolecular regulation 257–8neurotrophins and 402–3, 405regeneration programs and 415site of axotomy and 415see also neuronal death
NeuroPage 153, 483–4neuropathic paincortical reorganization 291–3GABAergic neuron
replacement 446
pharmacological therapy 295spinal cord injury 623
neurophysiological testsspinal cord injury 617–19see also electrodiagnostic tests
neuropilin 1 (Nrp1)after brain injury and stroke
203axon guidance 306regulation of axon
regeneration 358neuropilin-2, synaptic pruning
324neuropilins 305, 358neuropraxia, electrodiagnostic
testing 78, 81neuroprostheses see neural
prosthesesneuroprotectionaxonal, in demyelinating
diseases 466by enhanced somatosensory
input 136spinal cord injury 249
neuropsychologist 283neurorehabilitation
see rehabilitationneurospheres 290–1, 370, 441NeuroText 484neurotmesis, electrodiagnostic
testing 81neurotransmitter receptorsdenervated neurons 2–3injured spinal cord 178
neurotransmittersautonomic nervous system
415, 417facilitating synaptogenesis
318–19synaptic transmission 36asynchronous release 40phasic release 39quantal mechanisms 38
neurotrophic factors (NTFs,trophic factors)
delivery by gene therapy514–22
molecular signaling 257–8neuronal development 255,
258peripheral axon regeneration
485role in neuropathology
258–61Schwann cell grafts into spinal
cord and 501–2therapeutic potential 259, 245see also growth factors,
neurotrophin(s)neurotrophic hypothesis of
neural development 255,257, 400
neurotrophic tyrosine kinasereceptor (NTKR) genes30
Index
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neurotrophin(s) (NTs) 400–8axon guidance 306axon regeneration 402–8, 418cellular actions 400–1family members 400hearing impairment 545peripheral nerve injury 402–5receptors 400signal transduction 400–1spinal cord injury 404–8, 418acute vs. chronic lesions 406cell survival effects 405changes in expression 405–6effects on specific fibertracts 407–8
functional effects 182, 406–7methods of administration406
neurotrophin-3 (NT-3) 400gene polymorphism 30peripheral nerve injuryaxon regeneration and403–4
cell survival effects 402–3peripheral neuropathy therapy
521receptor 400spinal cord injuryaxon regeneration and 385,406
fiber tract specificity 408functional effects 406–7gene therapy 406, 521with Schwann cell grafts 501
neurotrophin-4 (NT-4, NT-4/5)400
axon regeneration after spinalcord injury 408
cell survival after spinal cordinjury and 405
receptor 400neurovascular niche, post-stroke
neurogenesis 205NeuroVR 201neurturin (NTN) 519–20NeuRx Diaphragm Pacing
System® 126newts, adult neurogenesis 284NFIL3 (nuclear factor regulated
by IL-3) 421–2NG2 (neuroglycan 2) 157, 381NG2+ cells 286glial scar 380role in axonal regeneration
372–3stabilization of dystrophic
growth cone 384see also oligodendrocyte
precursor cellsnicotinamide mononucleotide
acetyltransferasessee Nmnat1, Nmnat2,Nmnat3
Nintendo Wii 201–2, 209–10nitric oxide (NO)
autonomic function 417neurodegenerative diseases
261–2NMDA (N-methyl-D-aspartate),
initiation of locomotion171, 181
NMDA antagonists, traumaticbrain injury 539
NMDA receptors (NMDA-R) 52associative learning in Aplysia
68–9cerebral palsy 214fragments, traumatic brain
injury 536locomotion control 181–2long-term depression 55–6long-term potentiation 53metaplasticity 57neurodegenerative diseases
262retinal ganglion cell axon
development 117retinal ganglion cell axon
regeneration 119synaptogenesis 319–21, 323–4
Nmnat1 275–6Nmnat2 276Nmnat3 276NOD-like receptors (NLRs),
Alzheimer’s disease 394nodes of Ranvier 369, 457action potential conduction
459remyelinated axons 464sodium channels 458
Nogo 203, 340–1, 350–1changes after stroke 204gene cloning 340–1gene knockout studies 342–3,
351inhibition of axon regeneration
309, 418–19inhibition of axon sprouting
343isoforms 340–1, 350neutralizing agents 342, 244–5receptors 341–2, 352–3signaling pathway 204,
309–10, 341–2, 354synaptic plasticity and 345
Nogo-A antibodiesdevelopment 340, 342, 350preclinical studies 80, 179, 340
Nogo receptor 1 (NgR1) 204,341–2, 352
antagonists 342, 355co-receptors 309–10, 342,
352–3inhibition of axon
regeneration and 418signaling pathway 354synaptic plasticity and 345
Nogo receptor 2 (NgR2) 204,341–2, 352
Nogo receptors (NgR) 309, 342
inhibition of axonregeneration 309–10
noise exposure, loud 134nonassociative learning 23,
63–71Aplysia 23, 64–8emerging principles 71forms 63
non-convulsive status epilepticus(NCSE) 265
noninvasive brain stimulation(NBS, NIBS) 141–7
cognitive rehabilitation 146–7,219–35
choice of technique 221clinical evidence 227–31diagnostic applications223–4
focal lesions 225with other therapeuticinterventions 224–5
technical and otherchallenges 225–7
theoretical framework221–3
deforming spastic paresis320–1
dementia 528neurorehabilitation strategies
246–8combined approaches 248facilitation of lesionedhemisphere 247–8
inhibition of healthyhemisphere 247
safety 142stroke 143–7techniques 219, 246see also transcranial direct
current stimulation,transcranial magneticstimulation
non-traumatic spinal cord injury(NTSCI) 615
noradrenergic pathways, controlof locomotion 182–3
norepinephrine (noradrenaline)415, 417
inducing locomotor activity171, 183
plasma, orthostatichypotension 421–2
norepinephrine transporter(NET) gene 30
Notch 205, 448Nottingham sensory assessment
(NSA) 300NT see neurotrophin(s)NT-3 gene polymorphism 30NTKR (neurotrophic tyrosine
kinase receptor) genes 30nuclear factor regulated by IL-3
(NFIL3) 421–2nucleus accumbens 27, 135nursing assistants 524
nursing homes 285nutritional supportdisorders of consciousness 392see also tube feeding
O2A precursor cellssee oligodendrocytetype-2 astrocyte (O2A)precursor cells
object recognition, auditory129–32
occipital cortexauditory activation in
blindness 129–30, 132auditory object recognition in
blindness 132blood flow in blindness 127metabolic activity in blindness
144see also visual cortex
occupational therapist (OT) 283occupational therapy (OT)disorders of consciousness
397–8multiple sclerosis 648stroke 10
octreotide 424ocular dominance columns,
development 116–17ocular dominance plasticity 160odor discrimination 29odor perception, blindness 141olfactory axons, growth of new
502–3olfactory bulb, adult
neurogenesis 286–7olfactory ensheathing cells
(OEC), spinal cordtransplants 496, 502–8
A- and S-cell populations 504axon regeneration after 373,
405, 504–6migration after 503myelin formation 506–8rationale 502–3tunnel formation 504
olfactory feedback, virtual realitysystems 201
olfactory stimulation, visualcortex in blindness 147
oligodendrocyte(s) 367, 369–71axon regeneration role 372–3development 368–72function and diversity 369myelination role 7, 457remyelination 464–5replacementdemyelinating diseases 465spinal cord injury 441–2
trauma-induced death 6–8oligodendrocyte lineage cells (OLs)axon regeneration role 372–3mechanisms of perinatal
injury 212–15stages of development 212–13
Index
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oligodendrocyte lineage cells (OLs)(cont.)vulnerability to perinatal
injury 212–13oligodendrocyte-myelin
glycoprotein (OMgp)203, 342, 351–2
after stroke 204gene knockout studies 343inhibition of axon
regeneration 309, 418–19receptors 341–2, 352–3signaling pathway 204,
309–10, 341–2, 354oligodendrocyte precursor cells
(OPCs) 367, 369–71,591
axon regeneration role 372–3cell surface markers 369–70glial scar 380injured spinal cord 448Schwann cell generation 373transplantsmultiple sclerosis 588spinal cord 441–2, 503, 589stroke 591–3
oligodendrocyte type-2 astrocyte(O2A) precursor cells368, 370, 438
transplant studies 441OMgp, OMG
see oligodendrocyte-myelin glycoprotein
online cognitive trainingprograms 219
open label clinical trials 234OpenViBE system 572operant conditioning
(instrumental learning)27–8
dementia 515–17neural mechanisms in Aplysia
69–70pain-related responses 291spinal stretch reflexes/
H-reflexes 88–91opioid analgesics 623Optacon 141optic atrophy protein 1 (Opa1)
263optic nerve 114damage, regeneration afterlower vertebrates 118–19,306, 332, 334
signaling pathways 11see also retinal ganglion cells
optic tectumdevelopment of retinal
connections 114–18regeneration of retinal
connections 118–20, 332,334
retinotopic map 114–15optimal linear estimator (OLE)
580
optokinetic stimulation, balancerehabilitation 113
oral feeding, disorders ofconsciousness 392, 396–7
ORMOSIL (organically modifiedsilica) 516
orthostatic hypotension 420–4initial 426management 422–4neurogenic 421supine hypertension 427symptoms 420–1
orthoticsenergy costs of walking and
377–8lower limb mechanical-
assisted 190–5motor neuroprostheses 253paraplegia 627powered 183–4tetraplegia 625–7upper extremity mechatronic
177, 183–4orthotist 283oscillopsia 360osteoporosis, spinal cord injury
624otitis media 132outcome measuresclinical trials 4–5, 235–8COSMIN checklist 39developing and testing 35–9dynamic approaches 38–9electrodiagnostic tests 81–2evaluative scale development
35–6applications 38generating items 35–6pre-testing 36reducing number of items 36testing 36–8
experimental spinal cordinjury see undersensorimotor functionassessment
floor and ceiling effects 41stroke rehabilitation 35–45laboratory gait analysis42–3
national guidelines 42neuroimaging-based 43–5principles of selection 40–2
walking 66–7oxidative stress 214, 261–2, 265oxybutynin 428, 641oxygen consumption, maximal
see VO2 max
P (synaptic release probability) 38mechanisms of increasing 40–1origins of short-term synaptic
plasticity 38p53 genotype 538p75 neurotrophin receptor
(p75NTF) 400
expression after spinal cordinjury 405–6
inhibition of axon growth309–10, 342, 352–3, 402
neuronal death and survival257, 401–2
peripheral axonal regenerationand 403
signaling 354P300-based brain–computer
interface 567–8P300 component, evoked
potentials 390–1PACE (promoting aphasics
communicativeeffectiveness) 438, 440
paclitaxel-induced painfulperipheral neuropathy 277
pager-based reminder systems153, 483–4
painamyotrophic lateral sclerosis
657assessment 393, 620chronic see chronic painexperimental spinal cord
injury 535multiple sclerosis 641neuropathic see neuropathic
painplasticity and 289–93post-polio syndrome 660post-stroke 263–4spinal cord injury 620, 623
paired associative stimulation,spastic paresis 321
paired-pulse facilitationsee facilitation
panic, ictal 554–5parallel fibers, cerebellar 56parallel group studies 235Paralyzed Veterans of America
(PVA) 532, 162paramedical treatment (PMT),
dystonia 578–9paraplegia/paraparesisgait disorder 64locomotor training 348–9lower extremity functional
electrical stimulation126–7
recovery and functionaloutcomes 627–8
see also spinal cord injuryparapyramidal region (PPR) of
medulla, control oflocomotion 172, 182
Parastep System® 127, 627, 630parasympathetic nervous system
415–16parietal cortexauditory spatial processing 128changes after stroke 85memory functions 32motor functions 102–3
reorganization in congenitaldeafness 132
visual cortical input 143PARK1 gene mutations 567parkin 260, 263–4, 268gene mutations 567
parkinsonism 567differential diagnosis 569–70MPTP-induced 260neuroimaging 568vascular 569
Parkinson’s disease (PD) 567–74apraxia 448, 455, 457balance control studies 96–7clinical features and diagnosis
567–8, 570–1deep brain stimulation 345,
543–4, 568–9dementia (PDD) 569exercise capacity 370gait disorder 344–5gene therapy 518–19genetics 567medical treatment 345, 424–5,
568–9neurobiology 567autophagic cell death 268inflammatory response 394mitochondrial dysfunction263–4, 277
neuronal cell death 260–1probabilistic learning 24rehabilitation 570–4balance training 572–3behavior modification 571–2exercise training 375, 570gait retraining 66, 571–2motor fluctuations 570–1noninvasive brain stimulation226–7, 231, 234
psychosocial counseling 574speech and swallowingtherapy 573–4
urinary dysfunction 427paroxysmal autonomic
instability with dystonia(PAID) 543
paroxysmal kinesiogenicdystonia/dyskinesia 577
participatory action research(PAR), dementia 526
passive movements, neglectrehabilitation 468
passive range of motiondisorders of consciousness 397exercises 315maximal, deforming spastic
paresis 313pasta-eating test 535–6pathogen-associated molecular
patterns (PAMPs) 214pathological cross-talk 460patient-reported outcomes
measurement informationsystem (PROMIS) 39
Index
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Pavlov, Ivan 24Pavlovian conditioning
see classical conditioningpaw placement test 534PC12 cell line, neurotrophin
signaling 401PDZ (PSD-95/Discs large/ZO-1)
domain proteins 55, 57PEAT (planning and execution
assistant and trainer) 153pediatric interactive therapy
system (PITS) 210pediatric patients see childrenpegylated neutral/anionic
liposomes 516pelvic support, wheelchairs 171penetrating brain injuries 385–6penumbral tissue 225, 384reperfusion 602reversibility of damage 15–16
perceptual training, neglect 469percutaneous intramuscular
electrodes 121Perdue pegboard test 605pericytes 367, 380perimetry, high resolution (HRP)
503–4perinatal brain injuryassociated with cerebral palsy
211–12etiological factors 212neural plasticity after 215–16pathophysiology of cerebral
palsy 212–15perineuronal nets (PNN) 155–7activity-related changes 161around CNS lesions 158chondroitinase ABC therapy
targeting 80, 160peripheral ganglia, denervation
supersensitivity 2peripheral nerve grafts 119, 475peripheral nerve injurychondroitinase ABC therapy
160electromyographic evaluation
81neurotrophins and axon
regeneration 402–5repair procedures 474sensory loss 298–9somatosensory system changes
78, 245spinal transections with 178–9see also axotomy
peripheral nerve regeneration339–40, 349
across lesion site 473–4between cut ends of nerves 475endoneurial tubes promoting
473–4historical note 472–3neurotrophins and 402–5role of Schwann cells 373, 403,
405, 472–86
peripheral nerve stimulation(PNSss) 135–8, 244–5
cortical effects 135–7, 244–5deforming spastic paresis 321paretic upper limb in stroke
137–8, 245pharynx in dysphagic stroke
138, 245rationale 135–7
peripheral nerves, functionalelectrical stimulation 120
peripheral nervous system (PNS)injury, sensory loss 298–9
peripheral neuropathies 655,660–4
electrodiagnostic testing 78–80gene therapy 518, 521–2quality of life 656see also axonal
polyneuropathiesperipheral somatosensory input
see somatosensory inputperiventricular hemorrhagic
infarction, perinatal 211periventricular leukomalacia
(PVL) 211–16PERK 266PerMMA (personal mobility and
manipulation appliance)167–8
perseveration 490persistent inward currents
(PICs), after spinal cordinjury 177–8
personal emergency responsesystem (PERS) 154
pesticides 260PET see positron emission
tomographyphagocytes, removal of dying
cells 258phantom limb pain/sensation
555behavioral interventions
293–4cortical reorganization 291–3pharmacological therapy 295somatosensory pain memory
concept 290–1phantom sensation, tinnitus as
auditory 133–5pharmacological therapychronic pain 295genetic influences on response
28–9human neurorehabilitation
241–3locomotor recovery after
spinal cord injury 181–4spinal cord injury 629–30stroke rehabilitation 242–4
Pharos Cognit 153pharyngeal stimulationcortical effects 136, 410–11dysphagic stroke 245, 138
phenobarbital 552–3phenol injections, deforming
spastic paresis 319phenytoin 466, 552–3ɸ-nodes 462phosphacan 157, 202, 381phosphatase and tensin homolog
deleted on chromosometen see PTEN
phosphatase PP2B/calcineurin 56phosphatidylinositol 3-kinase/
AKT (PI3K/AKT)pathway 257, 401
phosphodiesterase 4 (PDE4) 356inhibitor 356
phospholipase C (PL-C) 43phospholipase Cγ (PL-Cγ)
pathway 257, 401phrenic nerve pacing 126, 631physical activitychronic neurological
conditions 371–2exercise capacity and 369hippocampal neurogenesis and
289–90see also exercise
physical and rehabilitationmedicine (PRM) 283
physical therapist (PT) 283physical therapy (physiotherapy)disorders of consciousness 397dystonia 578multiple sclerosis 646Parkinson’s disease 570post-polio syndrome 659stroke, with pharmacotherapy
242–3physostigmine 541PICK1 protein 57Pick’s disease 260–1picture exchange communication
system (PECS) 227picture planner 153pilot studies 5PINK1 (PTEN-inducing putative
kinase 1) 260, 263–4, 268,277
PirB (paired immunoglobulin-like receptor B) 341–2,353
place cells, hippocampal 29placebo control groups 4, 234–5placebo effect 234, 412plan, rehabilitation 282–5planarians, CNS regeneration 329planning and execution assistant
and trainer (PEAT) 153plasma exchange 660, 664plasticity 555activity-dependent see activity-
dependent plasticityauditory functions 125–35cellular and molecular
mechanisms after injury196–207
cerebral motor functions 99–110cerebral palsy and neonatal
brain injury 215–16compensatory 91cross-modal, visual system
140–8experience-dependent
see experience-dependentplasticity
functional electricalstimulation and 120–1
genetic factors affecting 25–7homeostatic 2–3, 11–12mechanisms 241–2multisite and multilevel 88–91pain and 289–93primary 91reactive 91rehabilitation and 6, 109–10,
240–8, 284–5response to neural interfaces
555sensory retraining and 303,
305–6short-term see short-term
plasticitysomatosensory system 75–80spinal cord see spinal cord
plasticitystroke recovery 12–15underlying recovery 25visual connections 114–20see also synaptic plasticity
platelet-derived growth factor(PDGF) 287, 370–1
PlayStation, SonyEyeToy 200, 202, 209Move 202
plexins 358axon guidance 305–6synaptic pruning 324
pluripotent stem cells 435directed differentiation 437induced see induced pluripotent
stem (iPS) cellsisolation and properties 439neural induction 439see also embryonic stem (ES)
cellsPocket Endeavor software 153podiatrist 285poliomyelitis 659–60
see also post-poliomyelitissyndrome
polyamines 357polyglutamine (polyQ) repeat
diseases 260, 268see also Huntington’s disease
polymyositis 80, 665–6polyneuropathies 660–4
see also axonalpolyneuropathies,peripheral neuropathies
pontomedullary locomotorregion (PLR) 175
Index
697Page numbers in bold refer to Volume II and otherwise to Volume I.
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population vector algorithm(PVA) 580
positron emission tomography(PET) 84
aphasia rehabilitation 442blindness 127–30parkinsonism 568stroke 11–13, 44, 197swallowing control 409traumatic brain injury 537
post-poliomyelitis syndrome369–70, 375, 377,659–60
postprandial hypotension 422,424
postsynaptic density (PSD)317–20
postsynaptic potentials (PSP)36–8
postsynaptic terminal,differentiation 322–3
post-tetanic potentiation (PTP,potentiation) 36
Ca2+-dependent mechanisms42–3
quantal mechanisms 38synapse specificity 44–5vs. long-term potentiation
51see also long-term potentiation
post-traumatic epilepsy 392,542
post-traumatic stress disorder(PTSD) 265, 544, 629
post-traumatic syringomyelia623
postural controlseated, functional electrical
stimulation 127virtual reality-based
assessment 355see also balance control
postural hypotensionsee orthostatichypotension
postural orientation 105–10postural responses, automatic, to
perturbations 108–9assessment 111–12treatments addressing 114
postural stability (or equilibrium)105–10
assessment 355–6dynamic, during gait
see dynamic posturalstability during gait
limits of see limits of stabilitysee also balance control
postural support systems,wheelchair 170–2
postural tachycardia syndrome(PoTS) 425–6
postural verticality 107, 110posturing, daily 315posturography, dynamic 110–13
potassium channel blockersmultiple sclerosis 459, 640–1see also 4-aminopyridine
potassium (K+) channels,myelinated axons 458–9
potassium chloride co-transporter-2 (KCC2)178
potentiationlong-term see long-term
potentiationpost-tetanic see post-tetanic
potentiationshort-term (STP) 51
power, muscle 331PQRST technique 482practice effects, in
neurorehabilitation240–1
praxisneuroanatomy 453–5theoretical models 450–3see also apraxia
preclinical studiescriteria for translation to
humans 231–2neurorehabilitation 5
precursor cells, neural see neuralprecursor cells
preference-based stroke index(PBSI) 38
prefrontal cortex (PFC)executive control 492, 495memory functions 32,
490–2motor functions 102reward circuit 135ventromedial (VMPFC), role
in tinnitus 134–5visual cortical input 143
pregabalin 623prehension synergy 603premature infants, perinatal
brain injury 211premotor cortex (PM)axon sprouting after stroke
197, 200changes after M1 injury 107–8dorsal see dorsal premotor
cortexpost-stroke reorganization
85, 87, 89reorganization after brain
injury 55, 317ventral see ventral premotor
cortexpremyelinating oligodendrocyte
lineage cells (preOLs)injury in cerebral palsy 212mechanisms of perinatal
injury 212–15presence, virtual 198–9presenilins 259, 294pressure relief ankle–foot
orthosis (PRAFO) 397
pressure relief measuresdisorders of consciousness 397spinal cord injury 621upper limb orthoses 183wheelchair users 168
pressure ulcers 163, 622presupplementary motor area
(pre-SMA) 53, 99–100,103
presynaptic apparatus, assembly15, 319
presynaptic inhibition, spasticity346
priapism 620primary motor cortex (M1, area
F1) 51–3amputation-related plasticity
292brain–computer devices 581brain injury/stroke-related
reorganization 52–3,85–9, 91
cerebellar connectivity 143experience-dependent
plasticity 104–5focal lesionslocal reorganization after52, 317
recovery and compensationfor 57
remote changes after 55,106–8
neurons see upper motorneurons
organization 51–2, 101somatosensory input and
135–6transcranial magnetic
stimulation studies 142–3see also motor cortex
primary plasticity 91primary somatosensory cortex
(S1)changes after M1 injury 107–8enhanced sensory input and 135experience-dependent
plasticity 109plasticity in blindness 142reorganization in chronic
pain 289see also somatosensory cortex
primary visual cortex (V1)ablation, blindsight after 502congenital blindness 148cortical visual prostheses 546
primates, nonhumancortical motor areas 53, 99–103declarative memory 30–1emotional communication 131somatosensory system
plasticity 75–80spinal cord injury research
248, 537priming effects 16, 24prism adaptation, neglect 468
prisms, opticalneglect 468, 610visual field impairments 501
pro-oligodendrocytes 369probabilistic learning 24progenitor cellslineage-restricted see lineage-
restricted progenitorsmultipotent see multipotent
progenitor cellssubgranular zone (type-2 cells)
288terminology 283–4see also neural precursor cells,
neural stem cellsprogesterone 539prognostic studies, assessing
quality 587–90programed cell death (PCD)developing neurons 255–6,
258molecular regulation 257–8morphological features256–7
see also apoptosis, neuronaldeath
progranulin 261progressive supranuclear palsy
(PSP) 569apraxia 448, 457inflammatory response 394
progressively lowered stressthreshold (PLST) 523
prolyl 4-hydroxylase (PH)inhibition 159
PROMIS (patient-reportedoutcomes measurementinformation system) 39
proprioceptive feedback, neglectrehabilitation 469
proprioceptive reflexes 83development 85Parkinson’s disease 345, 571
propriospinal pathwayslocomotion control 167, 173–6locomotor recovery after
spinal cord injury 172–3,175–7, 179, 184
prosthesesimplantable neural see neural
prostheseslower limb mechanical-
assisted 190–5upper extremity mechatronic
177, 184–6proteasome 266protein(s)aggregation,
neurodegenerativediseases 264–7
synthesis, axon tip 424protein kinase A (PKA)axon guidance 308axon regeneration and 356behavioral sensitization 65–7
Index
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long-term potentiation 55regulation of neuronal survival
257protein kinase C (PKC)long-term depression 57long-term potentiation 54–5neuronal survival 257neurotrophin signaling 401post-tetanic potentiation 43sensitization in Aplysia
65–6protein kinase M (PKM), Aplysia
homolog 68protein tyrosine phosphatase
(PTP)σ 344–5, 381–2proteoglycansglial scar 360, 381see also chondroitin sulfate
proteoglycansproximity principle,
reinnervation 15pruning effect 12PSD-95 protein 55, 319, 323pseudoplasticity 76, 78psychiatric disordersafter temporal lobectomy
561–3critically ill patients 265deep brain stimulation 544in epilepsy 550–1, 553–6,
558–60epilepsy risk in 553–4spinal cord injury 628–9traumatic brain injury 543–4
psychogenic non-epilepticevents, post-surgical 562
psycholinguistic approach,aphasia 438–40
psychological interventions,multiple sclerosis 649
psychological/psychoeducationalapproaches, dementia523–6
psychosisafter temporal lobectomy 561ictal 555postictal (PIP) 555
psychosocial counseling,Parkinson’s disease 574
psychosocial problemsepilepsy 556–7, 559epilepsy surgery and 562
psychostimulants 393, 528, 540PTEN (phosphatase and tensin
homolog deleted onchromosome ten)
axon regeneration 11, 345,357, 379, 419–20
myelin-associated glycoproteinand 354
PTP (protein tyrosinephosphatase)-σ 344–5,381–2
pull-test maneuver, Parkinson’sdisease 572
pulmonary dysfunction, spinalcord injury 620, 622
pulmonary embolism (PE),spinal cord injury 620–2
punishment 63pure autonomic failure (PAF)gastrointestinal dysfunction
429orthostatic hypotension 422–4urinary dysfunction 428
purinergic receptors 393–4amyotrophic lateral sclerosis
395Schwann cell signaling 485
Purkinje cells, cerebellarsee cerebellar Purkinje cells
pushrim activated power assistedwheelchairs (PAPAW)164–5
putrescine 357pyramidal neurons, hippocampal
29
quadriplegia see tetraplegiaquality of life (QoL)epilepsy 550–1neuromuscular disorders 655–6polio 660spinal cord injury 628–9visual field rehabilitation
and 504quality of life in epilepsy
inventory (QOLIE) 550quantal content 38quantal hypothesis of
neurotransmitter release36–8
quantitativeelectroencephalogram(QEEG) biofeedback 481
quasi-experimental studies 2quipazine 182QYNAD (Gln-Tyr-Asn-Ala-
Asp) peptide 460
Rab proteins 277rabies virus, as neuronal marker
101Rac1 307–8radial nerve stimulation 137RAGE (advanced glycoxidation
end-products),Alzheimer’s disease 394
Ramón y Cajal, Santiagoaxon guidance 301axon sprouting 12CNS axon regeneration 1, 339,
496, 529peripheral nerve regeneration
472–3Ran binding protein (RANBP1)
416randomization 2–4, 234–5randomized controlled trials
(RCTs)
CONSORT checklist 2–3rehabilitationenrichment strategies 5interventions 4methodological quality 11multicenter 1–2
study designs 234–5see also clinical trials
range of motion see active rangeof motion, passive rangeof motion
rapamycin 420raphe cell transplants, spinal
cord injury 437Ras, long-term potentiation 54Ras-Raf-Mek-Erk pathway 401Rasch analysis 39, 591reachingcompensatory strategies after
stroke 600–2tasks, animal models 534–6virtual reality applications 208,
210reaction times, motor cortex
organization and 53reactive astrogliosis
see astrogliosis, reactivereactive oxygen species (ROS)
261–2, 265reactive plasticity 91reading aids 158reality orientation therapy 524–5reciprocating gait orthosis
(RGO) 127recoverydefinitions 8, 599–600genetic factors 25plasticity underlying 25stroke see stroke recoveryvs. outcome 7see also motor recovery
recreational therapist (RT, TRec)283
red nucleus 5, 56redundancyand compensation 603–5motor system 602–5referent body configuration
(R) concept 603redundancy gain (RG) 503redundant target effect (RTE) 503referent body configuration (R)
603reflexes, spinal cord injury 178–9regenerationaxon see axon regenerationinvertebrate nervous system
329–30non-mammalian models
329–35regeneration-associated genes
(RAGs) 243rehabilitation
(neurorehabilitation)278–86
acute stage of disease see earlyneurorehabilitation
brain–computer interface(BCI)-based 571
clinical pathways see clinicalpathways
clinical trials 1–6cognitive see cognitive
rehabilitationdefinitions 261, 278delivery 279, 281dose-response relationships
110early see early
neurorehabilitationeconomics 285–6experimental spinal cord
injury 160–1, 536–7genetic factors 25–30intensity see intensity of
therapylearning and 71motor recovery and
compensation 599–605multisensory approaches
148neuroplasticity and 6, 109–10,
240–8, 284–5outcome measures
see outcome measuresperipheral somatosensory
input and 244–6phases 261–2planning 282–5principles 279service provision 279–85Slinky model 279during therapeutic clinical
trials 233–4, 239timing after injury 109–10training and practice effects
240–1World Health Organization
model 278–9Rehabilitation Engineering and
Assistive TechnologySociety of North America(RESNA) 172
rehabilitation engineeringtechnologist (RET) 172
rehabilitation medicine 283rehabilitation nurse 283rehabilitation physician 283rehabilitation team 278–82members 282–3, 285specialized stroke unit 601
reinforcement 63reinnervationdenervated neurons 14–17early studies 1muscle see muscle,
reinnervationnew presynaptic
specializations 15priming effects 16
Index
699Page numbers in bold refer to Volume II and otherwise to Volume I.
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
reintegration to normal living(RNL) index 38
relay formation, injured spinalcord 446–8
reliability, outcomemeasurement 36
reminiscence therapy 524, 526remyelinationolfactory ensheathing cell
grafts and 506–8restoration of conduction
464–5Schwann cell grafts and 464–5,
497–9renin–angiotensin system 420reperfusion therapies, stroke 11repetitive strain injuries,
wheelchair users 161–2repetitive therapy, stroke
rehabilitation 605reproductive system dysfunction
429–30reptiles, axon regeneration 334repulsive guidance molecules
(RGMa, RGMb, RGMc)306–7, 344
RESCUE study 572resiniferatoxin, intravesical 428resistance trainingmultiple sclerosis 646upper extremity rehabilitation
336resources for enhancing
Alzheimer’s caregiverhealth (REACH) 527
respiratory complicationssevere brain injury 393spinal cord injury 622spinal muscular atrophy 658
respiratory failure, acuteneuromuscular 265
respiratory functionexercise capacity and 371polio patients 660spinal cord injury 620
respiratory system, effects of bedrest 266–8
respiratory trainingmultiple sclerosis 648spinal muscular atrophy 658
responsiveness, outcomemeasurement 37–8
restitution (functional)aphasia 438definition 7–8noninvasive brain stimulation
promoting 222vs. compensatory strategies 8–9
restless legs syndrome 567reticular formation, voluntary
motor control 56reticulon family of proteins 340reticulospinal-propriospinal
system, integrated 173–5reticulospinal tract
locomotor control 167, 172–3,179
neurotrophins and axonregeneration 408
post-stroke changes 86voluntary motor control 56
retinaimmature, waves of activity
118regeneration in amphibians
333–4retinal ganglion cells (RGC)
114–20axon development 114–18axon regeneration 118–20cAMP elevation and 356cell survival and 415developmental loss of ability414
inhibition by CSPGs 382lower vertebrates 118–19,306, 332, 334
molecules regulating 417,420
signaling pathways 11retinal prostheses 545–6, 554–5retinotopic map 114–15development 114–18regeneration 118–20
retraction balls 7, 9retrograde atrophy 4–6retrograde degeneration 4–7retrovirusesgene therapy vectors 515, 517labeling neural precursor cells
292reward learning/circuitry 27Rho GTPasesinhibition of axon
regeneration 309–10, 354,419
modulation of neuronalgrowth response 421
regulation by protein kinase A308
regulation of growth cones307–8, 359
as therapeutic target 355, 385,421
Rho kinase (ROCK) 421Rho/ROCK signaling pathway
158, 354rhythmic auditory stimulation
(RAS), Parkinson’sdisease 572
Rig1 308riluzole 260, 657rise-to-walk (RTW) test 42fluidity scale, evaluation
38, 43rising to walk 42rivastigmine 469, 479–80, 541Rivermead assessment of
somatosensoryperformance (RASP) 300
Rivermead mobility index (RMI),recovery after stroke 593
Robo (Roundabout) 304–5, 308,359
robotic systemsassisting gait training 65, 647functional electrical
stimulation with 124genetic influences on response
29lower limb rehabilitation
190–5mobility assistance 157upper extremity rehabilitation
177–83, 338robotic wheelchairs 166–7rolipram 356Ross’ syndrome 431rostral migratory stream (RMS),
migration of precursorcells 285, 287
rotary pursuit learning,Alzheimer’s disease520–1
Roundabout see Roboroute finding training, virtual
reality 208RPTP-σ (protein tyrosine
phosphatase-σ, PTP-σ)344–5, 381–2
RT300/RT600 devices 125rubrospinal tractlesions 5, 169, 405, 408voluntary motor control 56–7
Rutgers ankle rehabilitationsystem (RARS) 210
Rutgers Master II force feedbackglove 200–1
S1 see primary somatosensorycortex
S100β, traumatic brain injury 536saccadic exploration training
501–3sacral nerve root stimulators
129–30, 543, 630–1salamandersspinal cord regeneration 332–3visual system regeneration
333–4saliency of rehabilitation,
disorders ofconsciousness 394
salt loading, chronic 161SAP97 (synapse-associated
protein 97kDa) 55Sarm1 276scarcollagenous (fibrous) 158–9glial see glial scar
scavenger receptors 393schizophrenia 58, 207, 294Schwann cells (SC)axonal protection 277injured spinal cord 497–8
myelinating andnonmyelinating types 472
myelination role 457neuromuscular synaptic
remodeling and 482olfactory ensheathing cell
transplants and 507oligodendrocyte precursor
cell-derived 373peripheral nerve regeneration
373, 405, 472–86across lesion site 473–4causes of failure 484between cut ends 475–6damaged/regeneratedmuscle fibers 479–81
endoneurial tubes and473–4
escaped fibers 474–5, 478–9molecular mechanisms 403,484–6
nerve sprout formation 481reoccupation of synapticsites 481–2
sprouting of nerve terminal475–6
study methods 474vital imaging 476–9
remyelination of spinal cordaxons 464–5, 497–9
spinal cord transplants496–502, 508, 589–90
axon branching andterminal arborization499–500
axonal regeneration 500–1,505
gene transduction studies502, 521
migration properties 503with neurotrophic factors501–2
with olfactory ensheathingcells 502
plus other interventions501–2
rationale 496–7remyelination andconduction 497–9
territories, at neuromuscularjunction 482–4
transplants in multiplesclerosis 588
trophic support for axons 472tropic influences on growth
481schwannosis 497–8SCI see spinal cord injuryscoliosis supports, wheelchair
171scooters, mobility 157, 166seat cushions, wheelchair 170seated postural control,
functional electricalstimulation 127
Index
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seating protocols, disorders ofconsciousness 397
seating technology, wheelchairsee under wheelchairs
secondary brain injury 543secretases 259SeeMe virtual reality system 202seizurescognitive deterioration and
551–2hippocampal neurogenesis
induced by 289post-traumatic 392, 542psychiatric symptoms 554–5transcranial magnetic
stimulation-induced 142see also epilepsy
selective serotonin reuptakeinhibitors (SSRIs) 29, 608
selegiline 424–5self-awareness, lack of
see anosognosiaself-rehabilitation contracts 321self-stretch 315semantic dementia, apraxia
449–50semantic feature analysis (SFA)
439, 443–4semantic memory, neocortical
storage 31–2semaphorins 157, 203axon guidance 305–6brain lesions 203inhibition of axon
regeneration 309–10, 344,358–9, 382–3
spinal cord injury 158SENSe training program 304sensitive periods see critical
periodssensitization 23, 63chronic musculoskeletal pain
289intermediate-term 68long-term 66–8neural mechanisms 65–8short-term 65–6vs. classical conditioning 68see also facilitation
sensorimotor functionassessment
experimental spinal cordinjury 83, 529–37
bowel, bladder, andautonomic function 536
different paradigms 530–1forelimb motor recovery534–5
histopathology and 536integrative measures 535–6locomotor recovery 530,532–4
outcomes to measure529–30
rehabilitation and 536–7
sensory testing and pain535
white matter sparing 530human spinal cord injury
531–2, 617sensorimotor rhythmsECoG-based brain–computer
interfaces 568–9EEG-based brain–computer
interfaces 568sensorin 67sensory channel reweighting,
balance control 108sensory cortex see somatosensory
cortexsensory cueing, Parkinson’s
disease 571–2sensory loss (somatic) 298–307assessment see sensory testingassistive technology 154functional implications 299nature of impairment 298–9potential for recovery 300–1rehabilitation see sensory
rehabilitationsomatosensory system plasticity
after 76–80, 301–2sensory neurons (SNs)Aplysia reflexes 64neurotrophins and
regeneration 403–4transplantation into adult CNS
384see also dorsal root ganglion
(DRG) neuronssensory orientation (in balance)
107–8assessment 110–11treatments addressing 112–14
sensory rehabilitation 301–7efficacy 300–4future directions 306–7neural prostheses 544–6principles of plasticity and
learning 303, 305–6sensory stimulationdisorders of consciousness 395see also somatosensory
stimulationsensory testing 299–300experimental spinal cord
injury 535serial casting 316serotonergic (5-HT) neuronsregenerative ability 382transplantation studies 182
serotonin (5-HT)autonomic function 417hippocampal neurogenesis and
290locomotor control in rats
171–3, 179, 182mediating classical
conditioning 68mediating sensitization 65–7
serotonin (5-HT) agonists,locomotor effects 181–2,184
serotonin (5-HT) receptorblockers, locomotioneffects 181
serotonin (5-HT) receptors,injured spinal cord177–8
serotonin-transporter-linkedpolymorphic region (5-HTTLPR) 28
serotonin2 (5-HT2) receptorsinjured spinal cord 178locomotion and 182
serotonin7 (5-HT7) receptors,locomotion and 182
serpentine splint 315sertraline 559, 561sexual dysfunction 429–30, 641SF-36 (36-item short form health
survey) 67Shank protein 323shavers, electric 155Sherrington, Charles 529shoehorns, long-handled 155shopping, assistive devices 158short message service (SMS)-based
reminder systems 484short-term depression 36, 43–4quantal mechanisms 38synapse specificity 44–5
short-term (synaptic)enhancement (STE) 36
Ca2+-dependent mechanisms38–43
decay rates 42quantal mechanisms 38synapse specificity 44–5see also augmentation,
facilitation, potentiationshort-term memory see working
memoryshort-term plasticity 36–45quantal mechanisms 36–8synaptic specificity 44–5
short-term sensitization, Aplysia65–6
shoulder movementscompensatory 601–2post-stroke, predicting
recovery 334, 596stretch reflex thresholds 605
shoulder pain, hemiplegic (HSP)263–4
functional electricalstimulation 124
management 607shoulder subluxation, post-stroke
124showering, assistive technology
154sialic acid residues 352sign language, visual 132sildenafil 430, 641
SIMA (maintaining andsupporting independentliving in old age) study 517
single blind clinical trials 234single photon emission
computed tomography(SPECT)
parkinsonism 568stroke 12
siphon-gill withdrawal reflex,Aplysia 64
Sirt1 275–6sitting balance, post-stroke,
predictive value 595situational syncope 425skills training, dementia 519skin caredisorders of consciousness 392spinal cord injury 621
Skinner, B.F. 27SLC6A4 gene polymorphisms
28–9sleep disorders, traumatic brain
injury 544sleep/wake cycles, disorders of
consciousness 392Slinky model 279Slit proteinsaxon guidance 304–5, 308axon regeneration 310, 359,
383receptors 304–5
slow-wave sleep (SWS), non-invasive brainstimulation and 223
Smads 416smart wheelchairs 167smartphonesassistive technology 157, 159memory aids 153, 483–4see also mobile electronic
devicesSMARTWheel kinetic
measurement system 161SMS (short message service)-
based reminder systems484
soap dispensers 155social concerns, implanted neural
prostheses 550social problems, epilepsy 550–1,
556–7social reintegration, spinal cord
injury 628–9social worker 283SOCS (suppressor of cytokine
signaling) proteins, axonregeneration and 417
SOCS3, axon regeneration and11, 417, 420
SOD1 see superoxide dismutase,copper/zinc
sodium (Na+) channel blockers,demyelinating diseases466
Index
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sodium (Na+) channelsdemyelinated axons 460–1impedance mismatch andmatching 464–5
mechanisms ofredistribution 462
prior to remyelination 462transfer from glia 462–4
injured axons 462–3maladaptive expression in
demyelinating disease462, 464
myelinated axons 458olfactory ensheathing cell
grafts and 506putative blocking factors 460remyelinated axons 464subtypes 458
somatosensory cortexamputation-related plasticity
77, 245, 291–2plasticity after sensory loss 13,
77–8, 245developing systems 80time course andmechanisms 78–9
plasticity after visualdeprivation 142
post-stroke plasticity 196,301–2
axon sprouting 197, 200primary (S1) see primary
somatosensory cortexsynapse-specificity of short-
term plasticity 44–5visual cortical input 143
somatosensory evoked potentials(SSEPs)
disorders of consciousness 391spinal cord injury 618–19traumatic brain injury
398–9somatosensory functionassessment 299–300defined 298loss of see sensory loss
somatosensory input(peripheral) 244–6
disruption 76–80, 245–6cortical reorganization 76–9,245
developing systems 79–80treatments to promoterecovery 80
see also peripheral nerveinjury
functional relevance inhumans 136–7
increased see somatosensorystimulation
modulation in animals 135–6somatosensory neglect 465somatosensory pain memory
290–1somatosensory stimulation
animal studies 135–6in congenital deafness 132functional recovery and 244–5visual cortical areas in blind
animals 144see also peripheral nerve
stimulation, tactileperception
somatosensory system 75–80, 298balance control 108, 356complexity 75–6plasticity after injury and
sensory loss 76–80, 301–2developing systems 79–80immediate and short-term76–7
long-term changes 77–8time course andmechanisms 78–9
treatments to promoterecovery 80
somatotopic organization 75–6songbirds 131sonic hedgehog (Shh) 306, 370–1Sony PlayStation see PlayStation,
Sonysound localization see auditory
spatial functionsspaced repetition (or retrieval)
technique 481, 518, 526spared axon conundrum 9spastic co-contraction 312spastic dystonia 312spastic paresis, deforming
312–21clinical assessment 312–14impact of medications on
training 319–20management 314–21motor training 316–18noninvasive brain stimulation
320–1stretch therapy 314–16treatment of muscle
overactivity 318–19spasticitydefined 312, 542, 604denervation supersensitivity
2–3disorders of consciousness 392energy costs of walking 377functional electrical
stimulation 123–4gait disorder 345–8generalized, fallacy of concept
318–19grade 313local treatments 318–19multiple sclerosis 640spinal cord injury 177–8, 620,
623spinal cord plasticity and 84strength training and 332–3stretch reflex thresholds 605stroke 604–5
transcranial magneticstimulation and 320
traumatic brain injury 542–3spastin 277spatial navigation, virtual reality
applications 204–5spatial perceptionauditory see auditory spatial
functionstactile, blind humans 140–1
specificity of trainingdisorders of consciousness 394somatosensory loss 306stroke rehabilitation 10upper extremity rehabilitation
336–7αII-spectrin breakdown
products, traumatic braininjury 536
speech and language pathologist/therapist (SLP/SALT)223, 225–6, 283
speech and language therapy (SLT)disorders of consciousness
395–7multiple sclerosis 648Parkinson’s disease 573–4stroke 271, 443–4, 609see also aphasia, rehabilitation
speech brain-computer devices(BCIs), direct 579
speech disorders 437speech generating devices (SGD)
220, 223speech perception 125, 129–31aging effects 132–3early phonetic environment
and 131via cochlear implants 133
spermidine 357Sperry’s chemoaffinity (or
chemospecificity)hypothesis 115–18, 306,334
spina bifida, exercise capacity 370spinal commissural neurons,
axon guidance 302–3spinal cord 83–92isolated in vitro preparations,
locomotor activity 171,177
negotiated equilibriumconcept 90, 92
neural precursor cells 286oligodendrocyte development
370–2traditional view 83
spinal cord hemisection seeunder experimentalspinal cord injury
spinal cord independencemeasure (SCIM) 238–9
spinal cord injury (SCI) 155,242–50
adjustment to 628–9
assessment 616–21international core data sets616–17
neuroimaging 619–20neurological 617neurophysiology 617–19standardized protocols 616,618
see also sensorimotor functionassessment
autonomic dysreflexia 427,621–2
axon regeneration seeunder axon regeneration
clinical syndromes 617, 619clinical trials 249outcome measures 237–8principles of conductingvalid 231–40
depression 620, 628–9epidemiology 615exercise capacity 370experimental see experimental
spinal cord injurylocomotor function 61, 348–9,
627–8assessment 350prediction 624
lower vertebrates 330–4medical complications 621–4bladder function 427–8, 621gastrointestinal 429, 621reproductive 430thermoregulatory 431, 624
neurotrophins and repair404–8, 418
non-traumatic (NTSCI) 615pathophysiological responses
435–6, 530–1astrocyte functionaldiversity 370–2
axon sprouting 5–14denervation supersensitivity2–3
extracellular matrix 157–9glial scar 157–9inflammatory response417–18
oligodendrocyte death anddemyelination 6–8
retrograde degeneration ofcortical motoneurons 5–6
Schwann cell accumulation497–8
plasticity after see spinal cordplasticity, post-injury
prognostic factors 624–5recovery and functional
outcomes 624–8rehabilitation 160–1, 615–31body weight support system(BWSS) 628
body weight-supportedtreadmill training 65,630
Index
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Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
chondroitinase ABC therapywith 161
effects on plasticity 92,160–1, 536–7
exercise training 373, 375extracellular matrix changes161
functional electricalstimulation seeunder functional electricalstimulation
gait training see under gaittraining
neural prostheses seeunder neural prostheses
new and emerging methods629–31
by spinal level 625–8standard assessments 616strategies 155
therapies 242–50, 629–31aiding locomotor recovery180–4
cAMP elevation 159, 356cell-based see cellreplacement therapies,cellular therapies, stemcell therapies
chondroitinase seeunder chondroitinase
clinical translation 247–9combinatorial 245–6enhancing axonal plasticityand regeneration 243–5
gene therapy 518, 521, 247neurotrophins 406targeting extracellularmatrix 159–60, 244
traumatic 435–6, 615–16spinal cord injury locomotor trial
(SCILT) 65spinal cord plasticityactivity-dependent 83–92behavioral change and88–90
development 84–6importance 84motor skill acquisition andmaintenance 86–8
multisite nature 88–90normal life 84–8principles underlying 90–1recognition 83–4theoretical and practicalsignificance 91–2
post-injurychondroitinase plusrehabilitation and 161
chondroitinase therapy and159–60
chronic phase 161effect of rehabilitation160–1, 536–7
recovery of locomotion dueto 166–84
somatosensory system 77spontaneous 159
stroke recovery and 15spinal cord stimulationclinical studies 126, 548experimental spinal cord
injury 183–4spinal cord transection (complete
section) 529–32locomotor recovery in cats
166–9associated peripheral nervelesions 178–9
locomotor training effects180
at other spinal levels 168–9at T13 166–8
locomotor recovery in mice176–7, 180
locomotor recovery in rats171–2, 180–1
spinal fixation phenomenon,cerebellar lesions 84
spinal muscular atrophy (SMA)658–9
spinal pattern generator seeunder central patterngenerator
spinal shock 620spinal stretch reflexes see stretch
reflex(es)spinalization see spinal cord
transectionspinobulbar muscular atrophy
268splintsdynamic 315static 315–16
sprouting see axon sproutingsquid giant axons 457stair lifts 157stair test 42stairs, handrails 151–2standingcompensatory strategies after
stroke 15, 602functional electrical
stimulation for 126–7,547–8
spinal cord injury 126–7, 627Stargazin-like TARPs 55STAT3 (signal transducer and
activator of transcription3) 376, 417, 421
statistical analysis, clinical trials5, 240
statistical validity, prognosticstudies 589–90
status epilepticuscognitive impairment 552non-convulsive (NCSE) 265
steady-state visual evokedpotential (SSVEP)-basedbrain-computerinterfaces 568
Steele Richardson Olzewskysyndrome see progressivesupranuclear palsy
stem cell therapies 586–93memory dysfunction 479multiple sclerosis 586–8, 592spinal cord injury 439–48,
588–90, 592cell delivery methods 449clinical trials 449–50isolation and properties ofcells 437–9
time of engraftment 449stroke 590–3see also cell replacement
therapies, cellulartherapies
stem cells 591alternative sources, cell
replacement therapies448
multipotent see multipotentprogenitor cells
neural see neural stem cellspluripotent see pluripotent
stem cellsStemCells Inc. 441, 450stepping strategy, balance control
109, 114steroid sulfatase gene 28stigma, epilepsy 556–7stimulus generalization training
(SGT) 303–4stimulus–response (S–R)
learning 24Stimulus Specific Training (SST)
303–4STIMuSTEP™ 258STIWELL med4 257stochastic resonance effects,
noninvasive brainstimulation 223
strengthdefined 330inadequate, causing weakness
330–1, 333motor function and 331–2
strength trainingpost-polio syndrome 659upper extremity rehabilitation
332–3, 336stressfamily caregivers in dementia
526hippocampal neurogenesis and
283–90stress appraisal and coping
(SAC) model 628–9stress-induced analgesia 291stretchanimal research 314brief 314chronic 314–15deforming spastic paresis
314–16
modalities 315–16sustained 314
stretch reflex(es)adaptive changes in normal life
86–8development 85–6effects of stretch 314operant conditioning studies
88–91spasticity 346–7therapeutic applications of
conditioning 92thresholds 604–5
striatumadult neurogenesis 293reward circuit 27
STROBE (strengthening ofreporting ofobservational studies inepidemiology) 587
strobe light stimulation 117, 119strokeacute, complications and
comorbidity 263–4anosognosia 470apraxia 448–9, 452–5, 457depression after 607–8exercise capacity 370functional neuroimaging see
under functionalneuroimaging
gait disorder 63–4, 346–8, 604gene therapy 522interhemispheric competition
concept 144–5motor map plasticity 13–14,
85–9, 106, 108, 196neonatal 212neural repairparallelogram concept205–7
principles 196–207noninvasive brain stimulation
143–7outcome 7vs. recovery 7
predicting activities aftersee stroke recovery,predicting
reperfusion therapies 11sensory loss 299assessment 300recovery 300–1
severe 611stem cell therapies 590–3upper extremity weakness
330–3visual field deficits 500walking difficulties 61see also aphasia, dysphagia,
hemiplegia/hemiparesis,neglect, unilateral
stroke impact scale 67, 591stroke recovery 7–18Brunnstrom’s stages 603–4
Index
703Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
stroke recovery (cont.)cellular mechanisms 11–12,
196–207axon growth inhibitors 201–4axonal sprouting/newconnections 12–13,199–201
cellular regeneration 12–13,204–5
peri-infarct excitatorysignaling 197–9
early intensive training and16–17
efficacy of rehabilitation 9–11factors affecting 602functional neuroimaging
13–14functional or adaptive 602genetic influences 27–9mechanisms 8, 11–18, 602compensation vs. restitution8–9
compensatory strategies 15–16experience-dependentplasticity 12–15
future research needs 18modeling 17–18reversal of diaschisis 12salvage of penumbral tissue11–12
motor compensations 8,15–16, 595, 600–2
neurological 602peripheral somatosensory
input and 244–6predicting 7, 585–97ADL independence 593–4assessing research quality587–90
clinical relevance 597definitions 585–7functional neuroimaging43–5, 90–1
rationale 587upper limb function 333–4,595–7
walking ability 595spontaneous 9, 590impact on activities 592measuring impact 592–3mechanisms 602
terminology 7–9time course/patterns 9, 41,
590–2measuring role ofspontaneous recovery592–3
plateau in chronic phase 593vs. outcome 7see also under motor recovery
stroke rehabilitation 601–11acute stage (early) 262–72,
603–4aphasia see under aphasiaclinical pathways 73–4
constraint-induced movementtherapy see constraint-induced movementtherapy
dose–response relationships9–10, 110
dysphagia 609–10economics 285–6efficacy 9–11exercise training 9–10, 373, 375early phase 268–71
functional electricalstimulation 124–5, 547–8,605–6
gait training 190–5, 271, 348growth factor therapy 248intensity 9, 282–4, 604long term 611lower extremity 604–7energy costs of walking and378
neural prostheses 547–8mixed reality system 338–9models of delivery 601motor learning strategies 98noninvasive brain stimulation
143–7, 247–8cognitive functions 146–7,227–32
combined approaches 248inhibition of intact side 247stimulation of lesioned side247–8
outcome measures 35–45peripheral nerve stimulation
137–8pharmacological interventions
242–4pharmacological targets 241principle of neural repair
206–7role of prognostic information
587sensory retraining 302–4, 306severe stroke 611somatosensory stimulation
245spasticity management 604–5specificity 10task-oriented vs. repetitive
therapy 605timing 109–10, 16–17, 373,
603–4training and practice 241treadmill training 10, 190, 607unilateral neglect see
under neglect, unilateralupper extremity 330–9, 604–7clinical pathways 74early onset of therapy270–1, 335–6
functional electricalstimulation 124, 606
intensity of therapy 335–6outcome measures 337–8
peripheral nerve stimulation137–8
predicting prognosis 333–4recovery vs. compensation334–5
robotic therapy 178–82somatosensory inputinfluencing 244, 246
strength training 332–3see also constraint-inducedmovement therapy
virtual reality applications 43,204, 206–10
stroke rehabilitation assessmentof movement (STREAM)38, 40
stroke units, specialized 601–2stroke volume (SV), during
exercise 368stromal-derived factor (SDF1)
204Stroop paradigm 490stunned neural circuits, after
stroke 197–9subasis bar 171subcutaneous electrodes 255subgranular zone (SGZ) 285,
288–9fate of precursor cells 291neurogenic response to stroke
204type-1 cells 288type-2 cells 288type-3 cells 288
subplate neurons, perinatalinjury 215–16
substitution (functional) 7definition 8sensory, balance rehabilitation
113–14subthalamic nucleus (STN)
stimulation 543–4, 568–9subventricular zone (SVZ) 285adult neurogenesis 286–7fate of precursor cells 291neurogenic response to stroke
204–5suicide risk, spinal cord injury
629sulfatide 203sunlight exposure, Parkinson’s
disease 573superior colliculus (SC)auditory spatial perception 125blind animals 127–8denervation, chondroitinase
ABC therapy 160superior temporal cortex,
reorganization incongenital deafness 132
superior temporal gyrus (STG),speech processing 131
superiority trials 235superoxide dismutase, copper/
zinc (SOD1)
mutations in amyotrophiclateral sclerosis 260, 395,656
toxicity of mutant 264, 395–6supervisory attention system
(SAS) 491, 512–13supine hypertension 427supplementary motor area
(SMA) 53, 99–100, 103post-stroke changes 85–6, 89reorganization after brain
injury 55voluntary motor control 53–5
supportive services, dementiacaregivers 523
surface electrodes 121, 254–5swallowinganatomy 405–6difficulties see dysphagiaevaluation 407, 610acute phase 264disorders of consciousness396
stroke 407learned non-use 411–12neurophysiology 405–7phases 609–10therapy see dysphagia,
treatmentsweating disorders 431sympathetic nervous system
415–16sympathetic skin response (SSR)
618sympathomimetics, orthostatic
hypotension 423–4synapse(s)activity-dependent elimination
323–4ectopic, regenerating axons 10formation of new
see synaptogenesisneuromuscular junction 317reorganization after injury 1,
8–17, 200silent 54unmasking or disinhibition76, 78
specificitylong-term potentiation 51short-term plasticity 44–5during synapse formation323
structure of CNS 317–18synapse-associated protein
97kDa (SAP97) 55synapsin 65synaptic cell adhesion molecule
(SynCAM) 320–1synaptic plasticitylong-term and long-term
depression 50–8myelin-associated axonal
growth inhibitors and345
Index
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www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
short-term 36–45see also activity-dependent
plasticitysynaptic stripping 6, 482synaptic transmissionchemical 36–7newly forming synapses 319quantal hypothesis 36–8short-term depression
see short-term depressionshort-term enhancement
see short-term (synaptic)enhancement
synaptic vesiclesdepletion, causing depression
38, 43–4, 65function 36increased numbers, causing
augmentation 43phasic transmitter release
39quantal hypothesis 36–8during synapse formation
319synaptogenesis 317–24activity dependence 323–4adult brain 324CNS 317–24denervated neurons 14–15initial axon–dendrite contact
318–19molecular regulators 320–3glial-derived factors 322organizing postsynapticterminal 322–3
secreted factors 322trans-synaptic molecules320–2
neuromuscular junction 317specificity of synaptic
connections 323stroke recovery 12–13synaptic differentiation
319–20synaptotagmins 41–2SynCAM (synaptic cell adhesion
molecule) 320–1syncopeautonomic (neurally)
mediated 425vasovagal 420–1, 425
syndrome of inappropriateantidiuretic hormone(SIADH) 541
synergies, motor action 603α-synuclein 260, 567α-synucleinopathies 394syringomyeliafetal spinal cord transplants
437post-traumatic 623
tablet computerscommunication apps 221–3,
225
memory apps 153see also mobile electronic
devicestactile discrimination test (TDT)
300tactile hyperacuity taskblindness 141effects of practice 141visual cortical activation in
blindness 145tactile motion perception 142,
146tactile perceptionafter blindfolding 141, 144assessment measures 300blindness 140–1cross-modal visual cortical
involvement 142–4sighted subjects after practice
141visual cortical function in
blindness 145–7see also haptic discrimination
Tadoma method 141Tai Chi training 114tail-siphon withdrawal reflex,
Aplysia 64tailored activity program (TAP)
527–8TAJ see TROYTardieu scale 542target cellsavailability, and axon re-
growth after axotomy12
specificity of short-termplasticity 45
Tarlov and Klinger locomotorrating scale 532–3
TARPs (transmembraneAMPAR regulatoryproteins) 55
task-orientated training (TOT)stroke rehabilitation 10,
336–7, 605see also constraint-induced
movement therapytask specificity of training
see specificity of trainingtaste aversion learning 25taste stimulation, disorders of
consciousness 396tau 259, 394Parkinson’s disease 395traumatic brain injury 536
tauopathies, inflammatoryresponse 394
taxol 423tDCS see transcranial direct
current stimulationTDP-43 (transactive response
DNA-binding protein 43)260–1, 268, 395
team, rehabilitationsee rehabilitation team
telephonesassistive technology 157see also cell phones,
smartphonestelerehabilitation 66, 208, 212temperatureperception, testing 300regulation, disordered 430–1,
624short-term synaptic plasticity
and 43temporal lobe, memory functions
31–2temporal lobe epilepsy (TLE)hippocampal neurogenesis and
289, 294surgery see temporal
lobectomytemporal lobectomy 560neurological complications
562–3rehabilitation and 560–3seizures after 560
tenascin-C (TN-C) 158–9tenascin-R (TN-R) 157, 159, 383tendon transfers, spinal cord
injury 627tenodesis splints 626–7tension headache, chronic 289territorial competition,
hypothesis of 120–1, 246test–retest reliability 36tetrabenazine 577tetraplegiaautonomic dysfunction 421,
621functional electrical
stimulationbreathing assistance 126hand grasp and release127–9, 258–9
seated postural control 127intracortical brain–computer
interfaces 578–9recovery and functional
outcomes 625–7see also cervical spinal cord
injurytetrodotoxin (TTX)axonal neuroprotection 466resistant (TTX-R) sodium
channels 458retinotectal pathways 117–19
TGF see transforming growthfactor
thalamuspraxis 455reorganization after sensory
loss 77–8, 301thermal bathing technique 525thermoregulatory dysfunction
430–1, 624theta burst stimulation (TBS)
141, 219continuous (cTBS) 219
intermittent (iTBS) 219thoracic spinal cordlocomotion control in cats
166–8locomotion control in rats
171–2, 175–6threshold control theory 604–5thrombolysis, acute ischemic
stroke 9, 11thrombospondins (TSP) 159, 322thumb abduction supinator
splint (TASS) 315thyroid hormone 333tic disorders 579time cells, hippocampal 29timed-up-and-go (TUG) test
42, 112responsiveness 40–1
timed walking tests 40, 42Timocco motion capture system
202tinnitus 133–5, 555tissue plasminogen activator
(tPA) 9, 11, 233, 601–2tizanidine 605, 640toileting, assistive technology
151, 156Toilevator 156Toll-like receptors (TLRs) 393,
396Alzheimer’s disease 394amyotrophic lateral sclerosis
395cerebral palsy 214
tolterodine 428, 641tone and positioning splint
(TAPS) 315topiramate 552, 558torsinA 575torticollis, spasmodic see cervical
dystoniatotal end range time (TERT)
theory 315touchclinical tests 300see also tactile perception
Tourette syndrome 579toxic myopathies 80toxic polyneuropathy 664TP53 (p53) genotype 538trace conditioning 29–30tracheostomy 267–8Training BIG to move faster
program 570training effects, in
neurorehabilitation240–1
transactive responsive sequenceDNA-binding protein-43(TDP-43) 260–1, 268,395
transcranial direct currentstimulation (tDCS)141–2, 219–20
aphasia 443
Index
705Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
transcranial direct currentstimulation (tDCS) (cont.)cognitive rehabilitation 146–7clinical evidence 227–32, 234theoretical framework221–3
vs. transcranial magneticstimulation 221
deforming spastic paresis 320dementia 528neurorehabilitation role 247–8safety 142stroke 145–7visual field defects 505
transcranial magneticstimulation (TMS) 141,219–20
cognitive rehabilitation 147clinical evidence 227–32, 234diagnostic applications223–4
theoretical framework221–3
vs. transcranial directcurrent stimulation 221
deforming spastic paresis 320dementia 528with diffusion tensor imaging
224dystonia 576, 578with EEG (TMS-EEG) 224with functional neuroimaging
224genetic influences on
therapeutic response 29neurorehabilitation role 246–7paired pulse techniques 142–3praxis 453–4repetitive (rTMS) 141, 219safety 142stroke 87, 89assessing GABA signaling198
cognitive rehabilitation 147,227–32
motor rehabilitation 145predicting recovery 43–5,90–1, 596
swallowing control 409–10testing normal processes
142–3visual cortical function in
blindness 144visual cortical involvement in
tactile perception 142vs. transcranial direct current
stimulation 142transcranial magnetic
stimulation (TMS)-evoked potentials (TEP)224
transcription factors, modulatingaxon regeneration 421–2
transcriptome, post-stroke axonsprouting 200–1
transcutaneous electrical nervestimulation (TENS) 135,578
transcutaneous electricalstimulation of neckmuscles, neglect 468
transdifferentiation studies 448transdisciplinary team 281–2transforming growth factor-α
(TGF-α) 287transforming growth factor-β
(TGF-β) 67, 378transneuronal atrophy 3–4transneuronal degeneration 4transplantation therapies, cell
see cell replacementtherapies; cellulartherapies; stem celltherapies
transportation-related injuries 535traumatic brain injury (TBI)
535–44acetylcholinesterase inhibitors
480, 541acute phase treatment
391–400, 538–9biomarkers 536clinical syndromes 541–3diagnostic assessment 536–7disorders of consciousness
388epidemiology 535etiologies 385–6, 535exercise capacity 370exercise training 375genetic influences on outcome
27, 537–8military 535motor recovery 544neurobehavioral sequelae
543–4neuroimaging 536–7noninvasive brain stimulation
226post-acute interventions
539–41prognostic indicators 398recent clinical trials 538–41virtual reality applications
204–8see also consciousness,
disorders oftraumatic spinal cord injury
(SCI) 435–6, 615–16traxoprodil 539treadmill locomotiondorsolateral cord lesions 169energy expenditure 377experimental spinal cord
injury 166, 534unilateral hemisection 169–70VO2 max measurement 368
treadmill trainingapplying learning theories
100–3
body weight-supportedsee body weight-supported treadmilltraining
experimental spinal cordinjury 180
stroke rehabilitation 10, 190,607
see also exercise training, gaittraining
tremoressential (ET) 567, 569multiple sclerosis 640
trick maneuvers, Parkinson’sdisease 571–2
trihexyphenidyl 577trk (tropomyosin-related kinase)
receptors 400descending spinal pathways
408downstream signaling 401injured spinal cord 405neuronal uptake and transport
401regulating neuronal survival
402trkA 400–1trkB 400injured spinal cord 405peripheral axonal regeneration
and 403peripheral neuron survival and
402–3trkC 400trophic factors see neurotrophic
factorstropomyosin-related kinase
receptors see trk receptorsTROY 342, 352–3trunkcompensatory movements
600–1motion in space, vestibular
control 357–9muscles, vestibular inputs 357orientation, neglect 468
TSC1 (tuberous sclerosisprotein 1) 11, 379, 420
tube feedingdisorders of consciousness 392dysphagia 411
tumor necrosis factor (TNF)418
tumor necrosis factor-α (TNF-α)215, 323, 557
turtles, axon regeneration 334two-dimensionally (2D) varying
patterns, perception inblindness 140–1
ubiquitin fusion degradationprotein 2 (Ufd2 orUbe4b) 275
ubiquitin/proteasome system(UPS) 265
neurodegenerative diseases264, 266–7
relationship with autophagy267
ubiquitination, protein 66–7UCHL1 (ubiquitin carboxyl-
terminal hydroxylase)gene 30
Uhthoff’s phenomenon 642,647–8
ulnar nerve stimulationcortical effects 135–7paretic hand in stroke 137–8
UNAFET-4® device 256–7UNC-5 receptorafter stroke 203axon regeneration 310netrin binding 304, 358netrin signaling 358regenerating lamprey spinal
cord 415UNC-6 323UNC-40 304unfolded protein response (UPR)
265–6unilateral neglect see neglect,
unilateralunmasking see disinhibitionunmyelinated axons 457unresponsive wakefulness
see vegetative stateupper extremitybotulinum toxin injections
319repetitive strain injuries,
wheelchair users 161–2see also forelimb, grasping,
hand function, reachingupper extremity functionassessment 313, 337–8stroke 604–5predicting recovery 333–4,595–7
tetraplegia 625–7weakness and 330–3
upper extremity rehabilitation330–9
constraint-induced movementtherapy see constraint-induced movementtherapy
deforming spastic paresis 318dosage 335–6functional electrical
stimulation 124, 546–7,606, 630
future prospects 338–9interventions 334–7measurement of outcome
337–8mechatronic orthotics 177,
183–4mechatronic prosthetics 177,
184–6motor neuroprostheses 256–9
Index
706 Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
predicting motor recovery333–4
recovery vs. compensation334–5
robotics 177–83, 338specificity of training 336–7strength training 332–3, 336stroke see under stroke
rehabilitationtiming of onset 270–1, 335–6virtual reality applications
208–10, 338upper motor neuron (UMN)
lesionselectrodiagnostic testing 78strength training 332–3weakness 331–2
upper motor neuronscurrent views of function
51–2see also cortical motoneurons;
corticospinal tract axonsurinals 156urinary function see bladder
controlurinary tract, autonomic
dysfunction 427–9urinary tract infections (UTI),
spinal cord injury 623utterance-based technology 224
V1 see primary visual cortexVA-ROBOTICS study 179–81vagus nerve stimulation, tinnitus
135validityoutcome measurement 36–7prognostic research 588–90
valosin containing protein(VCP/p97) 276
valproic acid 447, 552–3vanishing cues technique 481–2,
516variability of practice 98–100context-conditioned 98–9gait training 102–3hypothesis 99
vascular dementia 511–12vascular endothelial growth
factor (VEGF)axon guidance 307gene therapy 520–2neural precursor cell responses
287, 290vascular endothelial growth
factor receptor 2(VEGFR2) 306–7
vascular parkinsonism 569vasopressin see arginine
vasopressinvasovagal syncope (VVS) 420–1,
425vectors, gene therapy 515–17VECTORS trial 336, 603–4, 607vegetative state (VS) 262–3, 387
emergence 398experience of pain 393incidence and prevalence 388
venous thromboembolism, spinalcord injury 620–2
ventilation, mechanicalsee mechanicalventilation
ventral funiculus, locomotorcontrol in rats 172–3
ventral premotor cortex (PMvand pre-PMv) 53,99–102
changes after primary motorcortex injury 107–8
reorganization after stroke85–6, 89
voluntary motor control 53–5ventrolateral funiculus (VLF)locomotor control in cats 167locomotor control in rats
172–3ventromedial prefrontal cortex
(VMPFC), modulation oftinnitus 134–5
ventroposterior nucleus ofthalamus, reorganizationafter sensory loss 77–8
VERITAS trial 269versican 202, 381vertebrates, non-mammalianadult neurogenesis 284–5nervous system regeneration
329–34optic nerve regeneration
118–19, 332, 334verticality, postural 107, 110vestibular dysfunctionassessment 355–6attentional demands 359dynamic visual acuity testing
360exercises see vestibular
rehabilitationfalls and falls risk 363–4postural instability 357–9
vestibular feedback, virtualreality systems 200–1
vestibular rehabilitation 360–4vestibular stimulationanosognosia 470neglect 468
vestibular systemcontrol of balance 108,
356–9stabilization of gaze 360
vestibulo-ocular reflex (VOR),balance control 359–60
vestibulospinal tract,neurotrophins and axonregeneration 408
Veterans Administration(VA)/Department ofDefense (DoD), strokecare guidelines 177
vibration exposure injuries,wheelchair users 162
vibration perception tests 300vibration stimulation of neck
muscles, neglect 468vibrotactile perceptioncongenital deafness 132congenital/early blindness 140visual cortical activation in
blindness 145video capture virtual reality
systems 199–200video feedback, neglect
rehabilitation 468, 471videofluoroscopic swallowing
evaluation (VFSE) 407, 610viral vectors 515safety concerns 522selection 516–17
virtual actionplanning–supermarket(VAP-S) 206
virtual automated teller machine(VR-ATM) 207
virtual classroom 203virtual MET (VMET) 206virtual office 204virtual reality (VR) 198–212based rehabilitationapplications 203–10attributes for 202–3balance 113, 209model 211Parkinson’s disease 573stroke 43, 204, 206–10upper extremity 208–10,338
vestibular dysfunction 362head mounted displays
(HMD) 199–201instrumentation 199–202key concepts 198–9postural control assessment
355video capture systems 199–200vs. computer games 182
virtual reality cognitiveperformance assessmenttest (VRCPAT) 205
vision restoration therapy (VRT)502–4
visual cortexauditory activation in
blindness 129–30, 132auditory object recognition in
blindness 132blood flow in blindness 127cross-modal involvement in
tactile perception 142–4modality-independent
perceptual-cognitivefunctions 147
neurorehabilitativeapplications of cross-modality 148
nonvisual tasks involving, inblindness 144–7
ocular dominance columns116
see also occipital cortex,primary visual cortex
visual cueingParkinson’s disease 571–2unilateral neglect 467–8
visual deprivationauditory activation of occipital
cortex 129monocular, chondroitinase
therapy 160somatosensory cortical
plasticity 142sound localization 126–7neural basis ofimprovements 127–9
visual cortex involvement innonvisual tasks 144
see also blindnessvisual feedbackrehabilitation robotics 181–2virtual reality systems 199–200
visual field impairment 500–5ADL and quality of life
measures 504–5after temporal lobectomy 562mechanisms for recovery
503–4rehabilitation 500–3
visual imageryneglect rehabilitation 469during tactile perception
143–4visual loss see blindnessvisual neuroprostheses 545–6,
554–5visual scanning training, neglect
467visual scene displays 220, 222,
225–6visual systemanatomy in blindness 147–8balance control 107–8, 356critical period for development
140cross-modal plasticity 140–8plasticity of connections
114–20regeneration in amphibians
333–4visual word form area (VWFA)
147visuohaptic shape representation,
common 143visuoperceptual assessment,
dementia 512visuospatial neglect 463, 465vitamin D deficiency,
Parkinson’s disease 573VMall 206, 209VO2 max (maximal oxygen
consumption) 367
Index
707Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information
VO2 max (maximal oxygenconsumption) (cont.)effects of bedrest 270, 369during exercise 367–8factors affecting 368–9measurement 368–9neurological disorders 369–72training-induced increases
268, 372VO2 peak 368neurological disorders 369–72training-induced increases 372
Vocare bladder control system129–30, 428–9, 543
vocational rehabilitationepilepsy 558multiple sclerosis 649
vocational rehabilitationtherapist (VR) 283
voice organizer 484vOICe technology 132voiding, voluntary control
see bladder controlvoluntary motor control 51–7descending tracts 55–7non-primary cortical motor
areas 53–5parallel distributed model 53primarymotor cortex (M1) 51–3role of spared territory in
recovery 57VR-DiSTRO 204
WalkAide® 256–7walkers 156walking 61–8assessment 62–4, 313–14assistive devices 64, 114, 156–7difficulties 61energy expenditure during
374–8outcome measures 66–7post-strokecompensatory strategies15–16, 602
functional electricalstimulation 125
predicting recovery 595see also foot drop
retraining see gait trainingspinal cord injury 61, 348–9,
627–8assessment 350functional electricalstimulation 126–7
prediction 624see also gait, locomotion
walking canes 114, 156walking competencydefined 40electromechanical-assisted gait
training and 193stroke, selecting outcomes to
measure 40–2gait speed 40–1more complex tests 41–2
walking index for spinal cordinjury (WISCI) 67
walking speed (or velocity)electromechanical-assisted gait
training and 193energy expenditure and 377gait kinetics and 43as measure of walking
competency 40–1recovery after stroke 593reliability and validity 40
walking tests 313–14timed 40, 42
Wallenda 416Waller, Augustus 274Wallerian degeneration 4, 7,
274–6active nature 275–6electrodiagnostic testing 78granular degeneration of
cytoskeleton 275indirect 5, 7latent phase 274oligodendrocyte death and
6, 8Wallerian-like degeneration 278–9washout period 235water temperature control
devices 154weaknessdefined 330electrodiagnostic testing 77–80
as inadequate strength 330–1,333
pathophysiology 331–2upper extremity 330–3motor function and 331–2strength training 332–3
Wechsler adult intelligencescale–revised (WAIS-R)512
Weiss, Paul 301wheelchair usersaccidental injuries 162functional electrical
stimulation for posturalcontrol 127
mobility within home 157pressure ulcers 163upper extremity repetitive
strain injuries 161–2vibration exposure injuries 162
wheelchairs 156–7, 161–73active indoor/outdoor-use 165amyotrophic lateral sclerosis
657applying evidence-based
practice 172–3depot 163electric powered (EPW) 165–8with elevating seats 169lightweight manual 163manual 163–4as motor vehicle seats 162positioning hardware 170–2preventing secondary
conditions 161–3pushrim activated power
assisted (PAPAW) 164–5robotic 166–7seat cushions 170with specialized features
168–70spinal cord injury 625–7stand-up 169–70standards 172–3tilt and recline functions 168–9ultralight manual 163–4
whisker maps, plasticity 13, 142whole-body vibration training,
post-polio syndrome 659
Wii, Nintendo 201–2, 209–10Wingless (Wg) proteins 306wisteria floribunda agglutinin
(WFA) 156, 158withdrawal reflexesAplysia 64, 68–9see also flexion-withdrawal
reflexesWlds fusion protein 275–6Wlds mouse 275Wnt proteins 306, 322Wolf motor function test
(WMFT) 338work see employmentworking memory 478, 491–2,
495dementia rehabilitation and
517frontal lobe lesions 490
World Health Organization(WHO)
model of rehabilitation 278–9see also International
Classification ofFunctioning, Disabilityand Health
wrist-driven flexor hinge splint626
wrist position sense test 300writer’s cramp 576–8
see also hand dystonia, focalwriting aids 158
Xbox Kinect gaming system200, 202
yohimbine 175, 181young animalsregenerative ability 8, 380, 414retrograde degeneration and
atrophy 5
zebrafish, neural regeneration284–5, 331–2
zero-sum effect, noninvasivebrain stimulation 223
zolpidem 540zymosan 385
Index
708 Page numbers in bold refer to Volume II and otherwise to Volume I.
www.cambridge.org© in this web service Cambridge University Press
Cambridge University Press978-1-107-01168-7 - Textbook of Neural Repair and Rehabilitation: Volume II – Medical Neurorehabilitation: Second EditionEdited by Michael E. Selzer, Stephanie Clarke, Leonardo G. Cohen, Gert Kwakkel and Robert H. MillerIndexMore information