Subcommittee on Toxicology and Risk Assessment

Chair: John Duffus, U.K.

Members: Ole Andersen, Denmark

Rita Cornelis, Belgium Birger Heinzow, Germany

Paul Illing U.K.

Nelly Mañay, Uruguay

Gunnar Nordberg, Sweden

Monica Nordberg, Sweden

Mike Schwenk, Germany

Wayne Temple, New Zealand

Doug Templeton, Canada

Philip Wexler, U.S.A

Howard Worth, U.K.

Background •  Developed from the IUPAC Commission on Toxicology, set up under Clinical

Chemistry

•  Founding Chair: Professor W. Sunderman

•  Members largely concerned with toxicity of metallic elements and analytical techniques; this is a continuing interest, with particular reference to chemical speciation

•  Other ongoing concerns have been risk assessment, exposure assessment and pesticides (with Division VI, Environmental Chemistry)

•  Terminology has been a matter of major concern and the current IUPAC approved Glossary of Terms Used in Toxicology is widely used as a standard reference work

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Terminology and Textbooks •  1993 - J. H. Duffus. “Glossary for Chemists of Terms Used in Toxicology”,

Pure Appl. Chem. 65, 2003-2122.

•  1993 - J. H. Duffus & H. G. Worth. “Fundamental Toxicology for Chemists”. Royal Society of Chemistry, Cambridge, U.K.

•  2006 - J. H. Duffus & H. G. Worth. “Fundamental Toxicology, 2nd edition”. Royal Society of Chemistry, Cambridge, U.K.

•  2007 - J.H. Duffus, M. Nordberg, & D. M. Templeton. “Glossary of Terms Used in Toxicology, 2nd Edition”, Pure Appl. Chem., 79, 1153–1341.

Adopted by the U.S. National Library of Medicine TOXNET Portal for ToxLearn Modules for public education in the fundamentals of toxicology

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Terminology and Textbooks •  Glossary of Terms in Toxicokinetics. M. Nordberg, J. H. Duffus, D. M.

Templeton. Pure Appl. Chem. 76,1033 (2004) http://www.iupac.org/publications/pac/2004/pdf/7605x1033.pdf

•  Explanatory Dictionary of Terms Used in Toxicology, Part 1. M. Nordberg, J. H. Duffus, D. M. Templeton. Pure Appl. Chem., 79, 1583 (2007) http://www.iupac.org/publications/pac/79/9/

•  Explanatory Dictionary of Terms Used in Toxicology, Part 2. M. Nordberg, J. H. Duffus, D. M. Templeton, Pure Appl. Chem. Under review. Note: The RSC is to publish Parts 1 and 2 of the Explanatory Dictionary in book form, when completed, as “Concepts in Toxicology”.

•  Glossary of Terms Used in Ecotoxicology. M. Nordberg, D. M. Templeton, O. Andersen, J. H. Duffus, 81, 829 (2009) http://www.iupac.org/publications/pac/81/5/

•  Glossary of Terms Used in Immunotoxicology. D. M. Templeton, J. H. Duffus, M. Schwenck, in preparation.

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Other Publications in PAC •  Workplace Risk Assessment

• http://www.iupac.org/publications/pac/2001/7306/7306x0993.html

•  Heavy Metal - An Unacceptable Term • http://www.iupac.org/publications/pac/2002/7405/7405x0793.html

•  Risk and Hazard Terminology • http://www.iupac.org/publications/ci/2001/march/risk_assessment.html

•  The Measurement of Volatile Organic Compounds • http://www.iupac.org/publications/pac/2000/7203/7203heinrich-ramm.html

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•  Guidelines for terms related to chemical speciation and fractionation of elements • http://www.iupac.org/publications/pac/2000/7208/7208templeton.html

•  Mechanisms of immunosensitization to metals (IUPAC Technical Report) • http://www.iupac.org/publications/pac/2004/7606/7606x1255.html

•  Diagnostic relevance of the lymphocyte transformation test for sensitization to beryllium and other metals (IUPAC Technical Report) • http://www.iupac.org/publications/pac/2004/7606/7606x1269.html

•  Cytokine profiles in human exposure to metals (IUPAC Technical Report) • http://www.iupac.org/publications/pac/2006/pdf/7811x2155.pdf

Other Publications in PAC

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Educational Projects •  IUPAC Toxicology Modules

•  http://www.iupac.org/publications/cd/essential_toxicology/ •  PDF format for ease of download and flexibility in use

•  Main objective to provide material from which teachers and lecturers could select what they wanted in accordance with the needs of their own students, supplementing it with examples relevant to the students’ own experience

•  Designed as a series of Powerpoint presentations

•  Targeted at students with a secondary school general science background

Educational Projects •  Toxicology in the classroom: pesticides and health •  The aim of the project is: a) to educate children on protecting themselves

from the harmful effects of pesticides; b) to give a safety culture for use of pesticides. The training material considers safe handling, protection from harmful effects, and how pesticides affect human health and the environment. Training materials have been prepared as CDROM, booklets and flip charts, and will be available on the internet. IUPAC Project 2004-045-1-700

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