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PenyebaranHematogen dari fokus primer infeksiTertelan basil M.tuberculosis dari sputum yang terinfeksiPenyebaran langsung kuman ke GITLimfogenPerkontinuitatumESTABLISHMENT

ALVEOLAR MACROPHAGE INGESTS TB BACILLIM. tuberculosis blocks phagolysosome formation by inhbiting Ca2+ signals and the recruitment and assembly of the proteins that mediate phagosome-lysosome fusion

SYMBIOSIS

Tubercle bacilli ingestedBy non activated newly recruitedMonocytes. SYMBIOSISIncapable alveolar macrophage bursts.New monocytes from blood are recruited to the site mainly by c5a, Monocyte Chemoattractant protein-1(MCP-1)TB bacilli multiplies in these non activated monocytes.7-21 days (