Amir naiberg

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  • 1. Technology Transfer from the Weizmann Institute of Sciencefrom our pipeline to your bottom lineAmir Naiberg, CEOYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om

2. The Weizmann Institute of ScienceDiscovering Basic Science Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science from the Weizmann Institute of Science w w w.YedaRnD .c omw w w .Yeda R n D .com 3. Weizmann Instituteof ScienceCuriosity DrivenResearchYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 4. What will beWho will the nextmake the scientificnext scientific revolution? revolution?Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 5. The next scientific revolution will be driven by scientists whohave a multidisciplinaryview of science the opportunity to takerisks the infrastructure to work the freedom to thinkYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 6. The Weizmann Institute of ScienceThe Pool of knowledgeMathematics ComputerChemistryBiologySciencePhysicsBiochemistryYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 7. The Weizmann Institute of ScienceQuality Driven Average number of citations per paperTechnionTAU HUJ WIS BGU Best Place in Academia BIU ranked No.1 in 2011 among top International academic Haifa Institutions TheScientist.comYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 8. ERC Starter+Established 2007-2010 35 30 25Success Rate (%) 20 15 1050Weizmann Technion Hebrew Tel Aviv Ben Gurion Bar Ilan HaifaYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 9. The Need to Rethink Innovation Company Total R&D Spending 1997-2011R&D Spending Per Number of Drugs ($Mil)Drug ($Mil)Approved AstraZeneca 58,95511,790.935 GlaxoSmithKline 81,7088,170.81 10 Sanofi63,2747,909.26 8 Roche Holding AG85,8417,803.77 11 Pfizer Inc. 108,178 7,727.03 14 Johnson & Johnson 88,2855,885.65 15 Eli Lilly & Co. 50,3474,577.04 11 Abbott Laboratories 35,9704,496.21 8 Merck & Co Inc67,3604,209.99 16 Bristol-Myers Squibb Co.45,6754,152.26 11 Novartis AG 83,6463,983.13 21 Amgen Inc.33,2293,692.14 9 Total 802,468 5,773139 Sources: InnoThink Center For Research In Biomedical Innovation; Thomson Reuters Fundamentals via FactSet Research Systems The Truly Staggering Cost Of Inventing New Drugs, Matthew Herper (Forbes, 10.2.2012)Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 10. The Israel National Centerfor Personalized MedicineBENCH TOBEDSIDEEnhancing medicaltreatment efficacyusing the mostadvanced researchtools Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 11. Personalized Medicine What is it? Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 12. The Israel National Center for Personalized MedicineInfrastructureSequencing Unit Proteomics UnitBuilding on the Weizmann CrownArising from the Weizmann AdvancedHuman Genome Center, the unit willMass Spectrometry Lab, the unit willprovide High Throughput DNA/RNA provide quantitative proteomicssequencing and affiliated analyses to study differentialbioinformatics to analyse genomic expression and post-translationalvariations, transcriptomes, non-codingmodifications of proteins.RNAs, and editomes.Bioinformatics Unit Small Molecules Screening UnitBuild on the Bioinformatics and Incorporating the Weizmann StructuralBiological Computing Group at Proteomics Unit for protein productionWeizmann, the unit will use advancedand structure determinationtools to identify promising genecapacities, the unit will screen smalltargets, key proteins and molecule and siRNA libraries forcritical pathways.desired biological effects. Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 13. Yeda Research & Development Co. Ltd.Bridging Research & Development Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science from the Weizmann Institute of Science w w w.YedaRnD .c omw w w .Yeda R n D .com 14. Yeda = KnowledgeApplied BasicTop Down Bottom upDemand driven Curiosity driven Secrecy Publish or PerishShort term Long term Risk taking Avoid commercial risksYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 15. Yeda Research & Development Co. Ltd.A World Leader in Technology Transfer Dozens of Weizmann-Inside products on the market. Total annual royalty-generating sales in 2011: Over $15 Billion. Over 50 new companies were established around Yedas technologies. Yeda owns the largest portfolio of patents in Israel: 560 live patent families, with more than 1,700 patent families filed since 1971. Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 16. Israeli Patents in the USA (Accumulated for the Years 2006-2010)450403400350325300250200 164 144 14115095 908710077 7763 62 61 61575750 0Yeda Research & Development Co. Ltd.Source: BDITechnology Transfer from the Weizmann Institute of Sciencew w w .Yeda R n D .c om 17. Governmental SupportYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 18. Innovation Capacity ScoreEnterprise Supportencourages growth ofdomestic biotechnologystartups and lures foreigncompanies to establishfacilities domestically.Source: SCEINTIFICAMERICAN/WORLDVIEW 2010 Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 19. Intervention Programs KAMIN60% 85%60% 90%Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 20. The Role of Governments Financial support for academic, basic research. Public support is essential for academic freedom. Intervention programs for bridging the gap. Legal infrastructure: intellectual property rights (IPR)laws, Taxations, corporate law, etc. Fixing market failures. Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 21. Global vs. Local Science is inherently global: it is like parachute, itonly functions when open; Scientists look for theinternational collaborators which most fit theirresearch needs. Industry aims at global markets; it looks for the bestinternational deals. Governments act Locally for national growth, forthe local industry, for jobs creation, etc.=> Government involvement is against internationalization of R&D.Yeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 22. Governments involvement in university-industry relations Under the responsibility of the office of the Chief Scientist atthe ministry of Industry, Trade and Labor (OCS). Different intervention programs for university-LOCALindustry collaboration. Restrictions on exporting of knowledge created under theseprograms. Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 23. Summary Israels example has shown that successful global TT cango together with excellent science and bring products to themarketplace. Acting globally scientifically and the freedom of operation of the TTOs were essential for this success and brought investments to Israel. Lately, governments policy is more dominant, trying toencourage LOCAL TT. EU, as a superstructure, should support cross bordertechnology transfer. Yeda Research & Development Co. Ltd. Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om 24. www.YedaRnD.com Thank youYeda Research & Development Co. Ltd.Technology Transfer from the Weizmann Institute of Science w w w .Yeda R n D .c om