100404 Amro Damanhoury

APPLICATIONS:

Benzyl Benzoate Application BP 2005Benzyl Benzoate Application is a cutaneous emulsion. It contains 25% w/v of Benzyl Benzoate in a suitable oil-in-water emulsified basis.

Extemporaneous preparation

The following formula and directions apply.

Benzyl Benzoate 250 gEmulsifying Wax 20 gPurified Water, freshly boiled and cooled

Sufficient to produce 1000 ml Melt the Emulsifying Wax, add the Benzyl Benzoate and mix. Pour the mixture into sufficient warm Purified Water to produce 1000 ml and stir thoroughly until cold.

LABELLING

The label states that the contents of the container should be shaken before use.

The label indicates the pharmaceutical form as 'cutaneous emulsion'.

Uses: Acaricide used in the treatment of scabies. Also effective in the treatment of pediculosis (infection with lice)

COLLODIONS:

Salactol PaintsSynonym: Lactic Acid and Salicylic Acid Paint A.P.F.

Extemporaneous preparation: The following formula and directions apply.Salicylic Acid fine powder 20 gLactic Acid 20 gFlexible Collodion ad 100 g

Salicylic Acid Collodion U.S.P. 1980 Salicylic Acid Collodion contains not less than 9.5 percent and not more than 11.5 percent of C7H6O3.

Salicylic Acid 100 gFlexible Collodion, a sufficient quantity, to make 1000 ml

Dissolve the Salicylic Acid in about 750 ml of Flexible Collodion, add sufficient of the latter to make the product measure 1000 ml, and mix.

Packaging and storage – Preserve in tight containers, at controlled room temperature, remote from fire.

Salicylic Acid Collodion B.P. 1999 Definition

Salicylic Acid 120 gFlexible Collodion sufficient to produce 1000 ml

Salicylic Acid Collodion B.P.C. 1973 Salicylic Acid 120 gFlexible Collodion 1000 ml

CREAMS:

Aqueous Calamine Cream B.P. 1999 Definition Aqueous Calamine Cream contains 4% w/w of Calamine and 3% w/w of Zinc Oxide in a suitable oil-in-water emulsified basis.

Extemporaneous preparation The following formula and directions apply.

Calamine 40 gZinc Oxide 30 gLiquid Paraffin 200 gSelf-emulsifying Glyceryl Monostearate 50 gCetomacrogol Emulsifying Wax 50 gPhenoxyethanol 5 gPurified Water, freshly boiled and cooled,

sufficient to produce 1000 g

Melt the Cetomacrogol Emulsifying Wax with the Self-emulsifying Glyceryl Monostearate, add the Liquid Paraffin and heat to about 60°. Dissolve the Phenoxyethanol in about 620 g of Purified Water at about 60°, add the oily phase to the phenoxyethanol solution and mix. Stir until cool, add sufficient Purified Water to produce 930 g and mix. Triturate the Calamine and the Zinc Oxide and incorporate in the cream.

Uses: Has a mild astringent action on the skin and is used to relieve the discomfort of dermatitis and to allay the pain and swelling of sunburn.

Aqueous Cream B.P. 1980 Aqueous Cream may be prepared in the following manner.

Emulsifying Ointment 300 gChlorocresol 1 gPurified Water, freshly boiled and cooled, 699 g

Dissolve the Chlorocresol in Purified Water with the aid of gentle heat. Melt the Emulsifying Ointment, add the solution of Chlorocresol while still warm, and stir gently until cold.

Aqueous Cream B.P. 1999 Definition

Emulsifying Ointment 300 gPhenoxyethanol 10 gPurified Water, freshly boiled and cooled,


The suitability of the Cream for use as a diluent should be confirmed before use.

Extemporaneous preparation Aqueous Cream may be prepared in the following manner.

Dissolve the Phenoxyethanol in sufficient Purified Water at about 60° to produce a total weight of about 700 g. Melt the Emulsifying Ointment, add the phenoxyethanol solution when both are at about 60° and mix. Stir gently until cool, add sufficient of the Purified Water to produce 1000 gand mix.

Uses: An emollient cream for the relief of symptoms of dry or chapped skin. Also used as a vehicle in pharmaceutical preparations.

Benzyl Benzoate Cream

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Extemporaneous preparation: The following formula and directions apply.Aqueous Cream B.P. 93 500 gBenzyl Benzoate Application B.P. 93 500 gUses: For the treatment of lice infection (pediculosis) and scabies.

Buffered Cream B.P.C. 1973Definition

Citric Acid Monohydrate 5 gSodium Phosphate 25 gChlorocresol 1 gEmulsifying Ointment 300 gPurified Water, freshly boiled and cooled 1000 g

Melt the emulsifying ointment with the aid of gentle heat, add the sodium phosphate, the citric acid, and the chlorocresol, previously dissolved in the water at the same temperature, and stir gently until cold.

Buffered Cream B.P. 1999Definition

Emulsifying Ointment 300 gDisodium Hydrogen Phosphate Dodecahydrate 25 gCitric Acid Monohydrate 5 gChlorocresol 1 gPurified Water, freshly boiled and cooled,


If another antimicrobial preservative replaces Chlorocresol in this formulation, the suitability of the Cream as a diluent should be confirmed before use.

Extemporaneous preparation Melt the Emulsifying Ointment with the aid of gentle heat. In a vessel that can be closed, heat about 650 g of Purified Water to about 60°; add the Chlorocresol and, when it melts, vigorously shake the closed vessel to effect dissolution. Dissolve the Disodium Hydrogen Phosphate Dodecahydrate and the Citric Acid Monohydrate in the chlorocresol solution. Add the aqueous phase to the melted ointment when both are at about 60°. Stir gently until cool, add sufficient Purified Water to produce 1000 g and mix.

Storage If Buffered Cream is kept in aluminium tubes, their inner surfaces should be coated with a suitable lacquer.

Cetrimide Cream B.P. 1999 Definition Cetrimide Cream contains the stated percentage w/w of Cetrimide in a suitable basis.


Cetrimide 5 g, or a sufficient quantityCetostearyl Alcohol 50 gLiquid Paraffin 500 gPurified Water, freshly boiled and cooled


Melt the Cetostearyl Alcohol and heat with the Liquid Paraffin to about 60°. Dissolve the Cetrimide in sufficient Purified Water to produce about 450 g. Add the aqueous solution to the oily phase when both are at about 60° and

mix. Stir gently until cool, add sufficient of the Purified Water to produce 1000 g and mix.

Labelling The strength is stated as the percentage w/w of Cetrimide.

When Cetrimide Cream is prescribed or demanded, no strength being stated, a cream containing 5% w/v shall be dispensed or supplied.

Cold Cream USPPetrolatum Rose Water Ointment USP XVI

Cetyl Esters Wax (Cetyl Palmitate) …….………… 125 g

White Wax (Beeswax)………………………….…… 120 gMineral Oil………………………………………..……. 560 gSodium Borate (Borax) ………………………..…… 5 gPurified Water ………………..……………………... 190 ml

To make about 1000 g

Reduce the cetyl esters wax and the white wax to small pieces, melt them on a steam bath with the mineral oil, and continue heating until the temperature of the mixture reaches 70O. Dissolve the sodium borate in the purified water, warmed to 70°, and gradually add the warm solution to the melted mixture, stirring rapidly and continuously until it hascongealed.

If the ointment has been chilled, warm it slightly before attempting to incorporate other Ingredients (see USP for allowable variations).

Use-Useful as an emollient, cleansing cream, and ointment base. It resembles Rose Water Ointment, differing only in that mineral oil is used in place of almond oil and omitting the fragrance. This change produces an ointment base which is not subject to rancidity like one containing a vegetable oil. This is a water-in-oil emulsion.

Reference: REMINGTON’S PHARMACEUTICAL SCIENCES

Hydroquinone CreamDefinition Hydroquinone Cream contains 4% w/w of Hydroquinone powder finely sifted in a suitable cream basis.

Reference: Remington: The Science and Practice of Pharmacy – 19 th Edition

Hydroquinone1,4-Benzenediol; p-Dihydroxybenzene; Hydroquinol; Quinol; Eldoquin and Eldopaque (Elder)Hydroquinone [123-31-9] C6H602 (110.11)

Preparation-Various processes are employed. One involved reacting a sulfuric acid solution of aniline with manganese dioxide and reducting the resulting p-benzoquinone with sodium bisulfite.

Description Fine, white needles, darken on exposure to air; melts 8 between 172 and 174O.

Solubility 1 g in about 17 ml water, 4 ml alcohol, 51 ml chloroform or 16.5 ml either.

Uses A hypopigmenting agent employed percutaneously to lighten localized areas of hyperpigmented skin, such as skin blemishes, lentigo, melasma, chloasma, freckles, etc. Its action is temporary, so that it is necessary to repeat the application at frequent intervals. It is a mild irritant, and erythema or rash may develop, which requires discontinuation of the drug. It should not be used near the

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eyes or in open cuts. It is to be used in children. Ingestion of 1 g results in tinnitus, nausea, vomiting, a sense of suffocation, shortness of breath, cyanosis, convulsions, delirium and collapse. Death has occurred with ingestion of 5 g. Irritation of the GI tract occurs with oral ingestion. Dermatitis results from skin contact. Corneal

Salicylic Acid and Sulphur Cream B.P. 1980Salicylic Acid, finely sifted 20 gPrecipitated Sulphur, 20 gAqueous Cream sufficient to produce 1000 g

Triturate the Salicylic Acid and the Precipitated Sulphur with a part of the Aqueous Cream until smooth, and gradually add the remainder of the Aqueous Cream.

Salicylic Acid and Sulphur Cream B.P.C. 1973Synonym: Salicylic Acid and Sulphur Application

Salicylic Acid, finely sifted 20 gPrecipitated Sulphur, finely sifted 20 gAqueous Cream 960 g

Triturate the salicylic acid and the sulphur with a portion of the aqueous cream until smooth and gradually add the remainder of the aqueous cream.

Avoid contact with metals.

Sulphur CreamPrecipitated Sulphur, finely sifted 10 gCold Cream USP 100 g

UREA CREAM B.P. 1993Urea 10 gAqueous Cream B.P. ad 100 g

Zinc and Castor Oil Cream B.P. 1993Synonym: Zinc and Castor Oil Ointment

Zinc Oxide, finely sifted 75 gCastor Oil 500 gCetostearyl Alcohol 20 gWhite Beeswax 100 gArachis Oil 305 g

Extemporaneous preparation The following directions apply.

Triturate the Zinc Oxide with a portion of Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40O.

Zinc and Ichthammol Cream B.P. 1999 Definition Zinc and Ichthammol Cream contains 5% w/w of Ichthammol dispersed in a suitable basis of which about 82% w/w is Zinc Cream.


Ichthammol 50 g

Cetostearyl Alcohol 30 gWool Fat 100 gZinc Cream sufficient to produce 1000 g

Melt together the Wool Fat and the Cetostearyl Alcohol with the aid of gentle heat, triturate the mixture with 800 g of Zinc Cream until smooth, incorporate the Ichthammol, add sufficient Zinc Cream to produce 1000 g and mix.

Zinc and Ichthammol Cream B.P.C. 1973Synonym: Zinc Oxide and Ichthammol Cream

Zinc Cream 820 gIchthammol 50 gCetostearyl Alcohol 30 gWool Fat 100 g

Melt together the wool fat and the cetostearyl alcohol with the aid of gentle heat, triturate the mixture with the zinc cream until smooth and incorporate the Ichthammol.

Zinc Oxide and Olive Oil CreamZinc Oxide, finely sifted 75 gOlive Oil 500 gCetostearyl Alcohol 20 gWhite Beeswax 100 gArachis Oil 305 g

Zinc Oxide Cream B.P. 1999 Definition Zinc Cream contains 32% w/w of Zinc Oxide in a suitable water-in-oil emulsified basis.


Zinc Oxide, finely sifted 320 gCalcium Hydroxide 0.45 gOleic Acid 5 mlArachis Oil 320 mlWool Fat 80 gPurified Water, freshly boiled and cooled


Mix the Zinc Oxide and the Calcium Hydroxide, triturate to a smooth paste with a mixture of the Oleic Acid and Arachis Oil, incorporate the Wool Fat and add gradually with continuous stirring sufficient Purified Water to produce 1000 g.

The suitability of the Cream for use as a diluent should be confirmed before use.

EAR DROPS:

Acetic Acid Ear Drops A.P.F. Extemporaneous preparation

Acetic Acid 33% 3 mlWater, freshly boiled and cooled to 100 ml

Mix.

Almond Oil Ear Drops B.P. 1999Definition Almond Oil Ear Drops are Almond Oil in a suitable container.

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Storage Almond Oil Ear Drops should be kept in a well-filled, well-closed container and protected from light.

Aluminium Acetate Ear Drops B.P. 1999Synonym: Aluminium Acetate Solution; Burow's Solution

Definition

Aluminium Sulphate 225 gCalcium Carbonate 100 gTartaric Acid 45 gAcetic Acid (33 per cent) 250 mlPurified Water 750 ml

Extemporaneous preparation The following directions apply.Dissolve the Aluminium Sulphate in 600 ml of the Purified Water, add the Acetic Acid and then the Calcium Carbonate mixed with the remainder of the Purified Water and allow to stand for not less than 24 hours in a cool place, stirring occasionally. Filter, add the Tartaric Acid to the filtrate andmix.

Storage Aluminium Acetate Ear Drops should be kept in a well-filled container and stored at a temperature not exceeding 25°. When aluminium acetate solution or Burow’s Solution is prescibed or demanded a solution complyimg with the requirements of this monograph shall be dispensed or supplied.

Boric Acid Ear Drops E.N.F.Boric Acid 2 gAlcohol (90%) to 100 ml

To be diluted with an equal volume of water when used for children.

Boric Acid Ear Drops (B.P.C. 1963, B.N.F. 1966)Boric Acid 18.3 gAlcohol or Industrial Methylated Spirit 208 mlWater to 1000 ml

Hydrogen Peroxide Ear Drops B.P.C.Hydrogen Peroxide Solution 25 mlWater ad 100 ml

Hydrogen Peroxide Solution means 6%, 20 Vol.

One step preparation:Hydrogen Peroxide 30%, 100 Vol. 50 mlWater ad 1000 ml

Ichthammol Glycerin Ear Drops B.P.C. 1973Synonym: Glycerin of Ammonium Ichthosulphonate

Ichthammol 100 gGlycerin 900 g

Olive Oil Ear Drops B.P. 1999 Definition Olive Oil Ear Drops are Olive Oil in a suitable container.

Storage Olive Oil Ear Drops should be kept in a well-filled, well-closed container and protected

from light.

Phenol Ear Drops B.P.C. 1973Phenol Glycerin 40 mlGlycerol to 100 ml

Caution: Dilution with water renders Phenol Ear-drops caustic; the preparation may be diluted with glycerol, if desired.

Phenol Glycerin (Reagent)Phenol 160 gGlycerol 840 g

Dissolve the phenol in the glycerol, with the aid of gentle heat if necessary.

Salicylic Acid Ear Drops A.P.F.Salicylic Acid 2 gAlcohol 90% 50 mlFreshly boiled and cooled water to 100 ml

Ref: Martindale 28th Edition

Sodium Bicarbonate Ear Drops B.P. 1999 Definition

Sodium Bicarbonate 5 gGlycerol 30 mlPurified Water, freshly boiled and cooled

sufficient to produce 100 ml


Dissolve the Sodium Bicarbonate in about 60 ml of Purified Water, add the Glycerol and sufficient Purified Water to produce 100 ml and mix.Sodium Bicarbonate Ear Drops should be recently prepared.

Spirit Ear Drops B.P.C. 1973Alcohol 95 percent 50 mlWater to 100 ml

In making this preparation the alcohol (95 percent) may be replaced by Industrial Methylated Spirit, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed.

ELIXIRS:

Paediatric Chloral Elixir B.P. 1999Paediatric Chloral Oral Solution

Definition Paediatric Chloral Elixir is an oral solution containing 4% w/v of Chloral Hydrate in a suitable vehicle with a blackcurrant flavour.

Extemporaneous preparation It is recently prepared according to the following formula and directions.

Chloral Hydrate 40 gWater 20 ml

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Black Currant Syrup 200 mlSyrup sufficient to produce 1000 ml

Dissolve the Chloral Hydrate in the Water, add the Black Currant Syrup and sufficient Syrup to produce 1000 ml and mix.

Labelling The label indicates the pharmaceutical form as ‘oral solution’.

EMULSIONS

Concentrated Peppermint Emulsion B.P. 1999 Definition Concentrated Peppermint Emulsion is a 2% v/v dispersion of Peppermint Oil in a suitable vehicle containing a non-ionic surface-active agent.


Peppermint Oil 20 mlPolysorbate 20 1 mlDouble-strength Chloroform Water 500 ml Purified Water, freshly boiled and cooled sufficient to produce 1000 ml

Shake the Peppermint Oil with the Polysorbate 20 and add gradually, shaking well after each addition, the Double-strength Chloroform Water and sufficient Purified Water to produce 1000 ml

EXTRACTS:

Ipecacuanha Liquid Extract B.P. 1999 Definition Ipecacuanha Liquid Extract is prepared from Ipecacuanha by a method stated under the general monograph for Extracts. It contains not less than 1.90% and not more than 2.10% of total alkaloids, calculated as emetine, C 29 H 40 N 2 O 4 .

Extemporaneous preparation Prepare by extracting Ipecacuanha with Ethanol (80 per cent) according to the following formula and directions.

Ipecacuanha, in fine powder 1000 gEthanol (80 per cent) a sufficient quantity

Action and use Expectorant.

Liquorice Liquid Extract B.P. 1999 Definition Liquorice Liquid Extract is prepared by extracting Liquorice with Purified Water and adding sufficient Ethanol (90 per cent) to give an ethanol content of 18% v/v in the final extract.


Liquorice, unpeeled, in coarse powder 1000 gPurified Water a sufficient quantityEthanol (90 per cent) a sufficient quantity

GLYCERINS :

Glycerin Borax Jap. Ph.

Borax 10 gSodium Bicarbonate 5 gGlycerin ad 100 ml Batch No.:

Tannic Acid Glycerin BPC 1973Tannic Acid 15 gGlycerol 85 g

Triturate the tannic acid with the glycerol and warm gently until solution is effected.Storage: It should be stored in airtight containers.

LINIMENTS :

Camphor Liniments BP, APF (BPC 1973)Synonym : Camphorated Oil

Camphor 20 gArachis Oil 100 gIt should be stored in airtight containers, in a cool place.

Methyl Salicylate Liniment B.P. 1999 Definition Methyl Salicylate is a cutaneous emulsion. It contains 25% v/v of Methyl Salicylate in Arachis Oil or other suitable fixed oil.

Labelling The label indicates the pharmaceutical form as ‘cutaneous emulsion’.

White Liniment B.P. 1999 White Embrocation

Definition White Liniment is a cutaneous emulsion.

Oleic Acid 85 mlTurpentine Oil 250 mlDilute Ammonia Solution 45 mlAmmonium Chloride 12.5 gPurified Water 625 ml


Mix the Oleic Acid with the Turpentine Oil. Dilute the Dilute Ammonia Solution with 45 ml of the Purified Water, previously warmed, add to the oily solution and shake to form an emulsion. Separately dissolve the Ammonium Chloride in the remainder of the Purified Water, add to the emulsion and mix.

Wintergreen Liniment A.P.F.Synonym: Methyl Salicylate Liniment Compound A.F.P.Methyl Salicylate 25 mlMenthol 4 gEucalyptus Oil 10 mlArachis Oil to 100 ml

LOTIONS:

Acne LotionErythromycin powder 20 gZinc Acetate 12 g

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Ethanol 96% ad 1000 ml

Aluminium Acetate Lotion Aqueous A.P.F.Synonym: Burow's Lotion

Definition

Aluminium Acetate Solution A.P.F. 5 mlFreshly boiled and cooled purified water

to produce 100 ml

It should be freshly prepared and used within 7 days.*To be used undiluted as a wet dressing.Note: Aluminium Acetate Solution (13%) for the preparation of Aluminium Acetate Lotion (0.65%) is available from Martindale (special order)

Boric Acid Eye Lotion B.P.C. 1963 (B.N.F. 1963)Boric Acid 3.43 gPurified water, freshly boiled and cooled to 100 ml

To be diluted with an equal volume of warm water before use.

Boric Acid Lotion 4%Definition

Boric Acid powder 40 mlPurified Water, freshly boiled and cooled sufficient to produce 1000 ml

Calamine and Sulphur LotionDefinition

Sulphur prec. 20 gCalamine Lotion U.S.P. ad 1000 ml

Ref: The National Formulary 1962(United Arab Republic – Ministry of Health)

Calamine Lotion B.P. 1999 Definition

Calamine Lotion is a cutaneous suspension.

Calamine 150 gZinc Oxide 50 gBentonite 30 gSodium Citrate 5 gLiquefied Phenol 5 mlGlycerol 50 mlPurified Water, freshly boiled and cooled sufficient to produce 1000 ml


Triturate the Calamine, the Zinc Oxide and the Bentonite with a solution of the Sodium Citrate in about 700 ml of the Purified Water and add the Liquefied Phenol, the Glycerol and sufficient Purified Water to produce 1000 ml.

Labelling The label indicates the pharmaceutical form as ‘cutaneous suspension’.

Calamine Lotion U.S.P., Phenolated Definition

Phenol Liquid 100 mlCalamine Lotion U.S.P. ad 1000 ml

Compound Borax Eye Lotion B.P.C. 1954Collyr. Borac. Co. (B.N.F. 1957)

Borax 1.6 gSodium Bicarbonate 1.6 gDistilled Water freshly boiled

and cooled to 100 ml

To be diluted with an equal volume of warm water before use.Ref.: Martindale 26th Edition page – 346

Hair Lotion Oil Bath Definition

Liquid Paraffin 40 mlCastor Oil 20 mlOlive Oil 20 mlCoconut Oil 10 mlAlmond Oil 10 mlLavender Oil (0.5%) q.s. (0.5 ml)Vitamin E (0.5%) (0.5 ml)

Emollient for the increased vitality promotes the growth of hair.Rub about 20 ml into the scalp before sleep. Shake the bottle before using. Keep out of the reach of children.

Extemporaneous preparation The following directions apply.Mix all ingredients.

D-Pantothenyl Alcohol Lotion (Bepanthene Lotion) Extemporaneous preparation

D-Pantothenyl Alcohol 5 gAlcohol 70% ad 100 ml

Phenol LotionLiquified Phenol 5 gCalamine Lotion to 1000 ml


Potassium Permanganate (B.P., Eur. P., U.S.P.)Soluble in 1 in 16 of water and 1 in 3.5 of boiling water giving purple solutions. An acidified solution in water is readily reduced by hydrogen peroxide, by easily oxidisable substances, and by organic matter.Store in well-closed containers avoiding contact with organic substances.

Uses Potassium Permanganate possesses oxidising properties which in turn confer disinfectant and deodorizing properties. It is also astringent. Though bactericidal in vitro its clinical value as a bactericide is minimized by its rapid reduction in the presence of body

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fluids. It is used as a 1 in 1000 solution in water as a cleansing application to ulcers or abscesses and as a 1 in 4000 solution as a gargle or mouthwash; freshly prepared solutions should be used. Solutions of similar strengths are used as wet dressings and in baths in eczematous conditions and acute dermatitis especially where there is secondary infection. A 1% solution has been used in bromhidrosis, in mycotic infections such as athlete's foot, and in poison ivy dermatitis. A 5% solution has a powerful styptic action. A 0.02% solution in water can be employed as a stomach wash-out in the treatment of poisoning by morphine, opium, and strychnine; its use should be followed by evacuation of the stomach. It is of no value in poisoning by atropine, cocaine, or the barbiturates. Potassium permanganate has been widely used as a first-aid treatment in snake bite but it is of no value for this purpose, though a solution will destroy any venom lying free on the surface of the skin.

Storage Store in airtight containers.Ref.: Martindale 28th Edition

Salicylic Acid and Coal Tar Lotion A.P.F.

Salicylic Acid 2 gCoal Tar Solution 5 mlCastor Oil 1 mlSpike Lavender Oil 0.1 mlIndustrial Methylated Spirit to 100 ml

Salicylic Acid and Sulphur LotionSalicylic Acid 20 gSulphur precip. 20 gPropylene Glycol 200 mlCastor oil 10 mlEthanol 96% ad 1000 ml

Salicylic Acid Lotion B.P. (B.P.C., B.N.F.)Definition

Salicylic Acid 20 gCastor oil 10 mlEthanol 96% to 1000 ml

Extemporaneous preparation Dissolve the Salicylic Acid in a portion of Ethanol 96% , add the Castor Oil and sufficient Ethanol 96% to produce 1000 ml and mix.

Scalp LotionResorcinol 20 gSalicylic Acid 20 gSodium Metabisulphite 0.1 gGlycerin 20 mlAlcohol 50% to 1000 ml


Sodium Bicarbonate Eye Lotion B.P. 1999 Definition Sodium Bicarbonate Eye Lotion is a sterile aqueous solution of Sodium Bicarbonate.


Dissolve the Sodium Bicarbonate in sufficient Purified Water, clarify by filtration, transfer the filtered solution into the final container, close the container so as to exclude micro-organisms and sterilise by heating in an autoclave.

Storage Sodium Bicarbonate Eye Lotion should not be kept in containers that have previously been subjected to heating in an autoclave.

Labelling The label states that any Eye Lotion not used within 24 hours of opening the container should be discarded.

When Sodium Bicarbonate Eye Lotion is prescribed or demanded no strength being stated, a lotion containing 2% w/v of Sodium Bicarbonate shall be dispensed or supplied.

Sodium Chloride Eye Lotion B.P. 1999 Definition Sodium Chloride Eye Lotion is a sterile aqueous solution containing 0.9% w/v of Sodium Chloride.


Dissolve the Sodium Chloride in sufficient Purified Water, clarify by filtration, transfer the filtered solution into the final container, close the container so as to exclude micro-organisms and sterilize by heating in an autoclave.

Labelling The label states that any Eye Lotion not used within 24 hours of opening the container should be discarded.

Sulphurated Potash and Zinc LotionSulphurated Potash 50 gZinc Sulphate 50 gRose Water to 1000 ml


White Lotion U.S.P. Lotio Alba: Lotio Sulfurata


Zinc Sulfate 40 gSulfurated Potash 40 gPurified Water, a sufficient quantity

To make 1000 ml

Dissolve zinc sulfate and sulfurated potash separately, each in 450 ml purified water, and filter each solution. Add slowly the sulfurated potash solution to the zinc sulfate solution with constant stirring. Then add the required amount of purified water, and mix.

Note: Prepare freshly and shake thoroughly before dispensing.

Uses: An astringent, protective and mild antimicrobial preparation. The astringency is attributal to the zinc ion. The tiosulfates and polysulfides in it exert antibacterial and antifungal actions (see Sodium Thiosulfate, RPS-16, page 1176). White lotion is used in the treatment of acne vulgaris.

Dose: Topical, to the skin, as required.

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Zinc Sulphate Lotion B.P. 1999 Definition Zinc Sulphate Lotion is a cutaneous solution. It contains 1% w/v of Zinc Sulphate in a suitable aqueous vehicle.

Labelling The label indicates the pharmaceutical form as ‘cutaneous solution’.

MOUTHWASH

Compound Sodium Chloride Mouthwash B.P. 1999 Definition Compound Sodium Chloride Mouthwash contains 1% w/v of Sodium Bicarbonate and 1.5% w/v of Sodium Chloride in a suitable vehicle with a flavour of peppermint.

Extemporaneous preparation The following formula applies.

Sodium Bicarbonate 10 gSodium Chloride 15 gConcentrated Peppermint Emulsion 25 mlDouble-strength Chloroform Water 500 mlWater sufficient to produce 1000 mlAdd: Colouring

Compound Sodium Chloride Mouthwash should be diluted with an equal volume of warm waterbefore use.

Hydrogen Peroxide Mouthwash B.P. 1999 Definition Hydrogen Peroxide Mouthwash is Hydrogen Peroxide Solution (6 per cent).

Storage Hydrogen Peroxide Mouthwash should be protected from light.

Labelling The label states, where applicable, that the Mouthwash contains a stabilising agent.

Povidone—Iodine Mouthwash B.P. 1999 Definition Povidone—Iodine Mouthwash is either an aqueous solution of Iodinated Povidone or it is prepared by the interaction between Iodine and Povidone.

The mouthwash complies with the requirements stated under Mouthwashes and with the following requirements.

NASAL DROPS

Argyrol Ephedrine Nasal DropsArgotone (Rona Laboratories)

Mild Silver Protein 1% 10 gEphedrine Hydrochloride 0.9% 9 gSodium Chloride Solution 0.5%Sodium Chloride 5 gDistilled Water to 1 Liter

Argyrol Ephedrine Nasal DropsArgyrol 5 gEphedrine Hydrochloride 1 gDistilled Water to 1 Liter

- Suitable for children if diluted to twice its volume water- To be freshly prepared


Ephedrine Nasal Drops B.P.C. 1973 Extemporaneous preparation The following formula applies.

Ephedrine Hydrochloride 0.5 gChorbutol; Acetone Chloroform 0.5 gSodium Chloride 0.5 gWater sufficient to produce 100 ml

Ephedrine Nasal Drops B.P.C. 1973 Ephedrine Hydrochloride 1.0 gChorbutol; Acetone Chloroform 0.5 gSodium Chloride 0.5 gWater sufficient to produce 100 ml(Suitable for children if diluted to twice its volume with normal saline)


Glucose and Glycerol Instillation A.P.F.Dextrose and Glycerin Nasal Drops


Glucose 2 0 gGlycerol ad 100 ml

Date of Prep: 31.08.2004 = 1 L

Customer: Ameera Pharmacy = 2 x 30 ml Glass Dropper

Menthol and Thymol Nasal Drops B.P.C. 1954Narist. Menthol. et Thymol

Menthol 457 mgThymol 229 mgCineole (Eucalyptol) 0.208 mlLiquid Paraffin (light) to 100 ml

Ref.: Martindale 28th Edition = page 352

Menthol Nasal DropsMenthol 1.0 gEucalyptol 0.2 mlCamphor 1.0 gLiquid Paraffin to 100 ml

- To be freshly prepared


Sodium Chloride Nasal Drops A.P.F.Normal Saline Nasal Drops BP

Extemporaneous preparation Dissolve.

Sodium Chloride 0.9 gWater freshly boiled and cooled ad 100 ml

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NASAL WASH

Alkaline Nasal Wash A.P.F.Extemporaneous preparation

Sodium ChlorideSodium BicarbonateBorax

Mix of equal quantities.

Alkaline Nasal Wash B.P.C. 1954Collun. Alk. (N.F. 1955)

Borax 1.37 gSodium Bicarbonate 1.37 gLiquefied Phenol 0.52 mlSucrose 2.29 gWater to 100 ml

To be diluted with an equal volume of warm water before use.Ref.: Martindale 26th Edition page – 346

Alkaline Nasal WashSodium Bicarbonate 5.0 gSodium Chloride 5.0 gBorax 5.0 gWater to 250 ml


Compound Alkaline Nasal WashCollun. Alk. (N.F. 1955)

BoraxSodium BicarbonateSodium Chloride- Equal quantities

For use dissolve about 1 g in 100 ml of warm water.Ref.: Martindale 26th Edition page – 346

Compound Borax Powder for Nasal Wash B.P.C. 1959Pulv. Borac. Co. pro Collun. (N.F. 1955)

BoraxSodium BicarbonateSodium ChlorideSucrose- Equal quantities

Ref.: Martindale 26th Edition page - 346

OINTMENTS

Ammoniated Mercury Ointment B.P. Definition Ammoniated Mercury Ointment contains 2.5% w/w of Ammoniated Mercury in Simple Ointment.


Ammoniated Mercury, finely sifted 25 gSimple Ointment 975 g

Melt the Simple Ointment, gradually add the Ammoniated Mercury and stir until cold.

Action and uses Ammoniated mercury is a mild antiseptic and is sometimes applied to the skin surrounding the perineum to destroy threadworms and to reduce reinfection. It was formerly used in the treatment of low-grade staphylococcal infections of the skin, and in psoriasis.

Precautions It should not be applied to raw surfaces because of the risk of absorption of mercury.

Ammoniated Mercury & Coal Tar Ointment B.P.C.Unguentum Hydrargyri Ammoniati et Picic Carbonis; Unguentum Picis Carbonis Compositum


Ammoniated Mercury 25 gStrong Coal Tar Solution 25 gYellow Soft Paraffin 950 g

Triturate the ammoniated mercury with a portion of the yellow soft paraffin until smooth, mix with the remainder of the yellow soft paraffin, and incorporate the strong coal tar solution.

Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.

Ammoniated Mercury, Coal Tar and Salicylic Acid Ointment B.P.C.Unguentum Hydrargyri Ammoniati et Picis Carbonis cum Acido Salicylico


Ammoniated Mercury and Coal Tar Ointment 980 gSalicylic Acid, in fine powder 20 g

Triturate the salicylic acid with apportion of the ammoniated mercury and coal tar ointment until smooth and gradually incorporate the remainder of the ointment.

Containers and Storage The directions given under Ointments (page 757) should be followed; containers should prevent evaporation.

Calamine Ointment B.P. 1999 Definition Calamine Ointment contains 15% w/w of Calamine in a suitable hydrophobic basis.


Calamine, finely sifted 150 gWhite Soft Paraffin 850 g

Triturate the Calamine with part of the White Soft Paraffin until smooth and gradually incorporate the remainder of the White Soft Paraffin.

Calamine and Coal Ointment B.P. 1999 Compound Calamine Ointment

Definition Calamine and Coal Tar Ointment contains 12.5% w/w each of Calamine and Zinc Oxide and 2.5%

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w/w of Strong Coal Tar Solution in a suitable water-emulsifying basis.


Calamine, finely sifted 125 gZinc Oxide, finely sifted 125 gStrong Coal Tar Solution 25 gHydrous Wool Fat 250 gWhite Soft Paraffin 475 g

Melt together the Hydrous Wool Fat and the White Soft Paraffin. Triturate the Calamine and Zinc Oxide in the melted basis and stir gently, when cooled, to about 40°. Gradually incorporate the Strong Coal Tar Solution and stiruntil cold.

Storage Calamine and Coal Tar Ointment should be kept in a container that minimizes evaporation losses.

Cetomacrogol Emulsifying Ointment B.P. 1999 Definition

White Soft Paraffin 500 gCetomacrogol Emulsifying Wax 300 gLiquid Paraffin 200 g

Extemporaneous preparation The following directions apply.Melt together and stir until cold.

Cetrimide Emulsifying Ointment B.P. 1999 Definition

White Soft Paraffin 500 gCetostearyl Alcohol 270 gLiquid Paraffin 200 gCetrimide 30 g


Melt together the White Soft Paraffin, Cetostearyl Alcohol and Liquid Paraffin, add the Cetrimide and stir until cold.

Coal Tar and Salicylic Acid Ointment B.P. 1999 Definition Coal Tar and Salicylic Acid Ointment contains 2% w/v of each of Coal Tar and SalicylicAcid in a suitable emulsifying basis.


Coal Tar 20 gPolysorbate 80 40 gSalicylic Acid 20 gEmulsifying Wax 114 gWhite Soft Paraffin 190 gCoconut Oil 540 gLiquid Paraffin 76 g

Disperse the Coal Tar in the Polysorbate 80, incorporate the Salicylic Acid and mix with the previously melted Emulsifying Wax. Separately, melt the White Soft Paraffin and the Coconut Oil, incorporate the Liquid Paraffin warmed to the same temperature and add, with stirring, the

resulting solution to the Coal Tar dispersion. Mix thoroughly and stir until cold.

Coal Tar and Zinc Ointment B.P. 1999 Definition Coal Tar and Zinc Ointment contains 30% w/w of Zinc Oxide and 10% w/w of Strong Coal Tar Solution in a suitable hydrophobic basis.


Strong Coal Tar Solution 100 gZinc Oxide, finely sifted 300 gYellow Soft Paraffin 600 g

Mix the Zinc Oxide with the Strong Coal Tar Solution, triturate with a portion of the Yellow Soft Paraffin until smooth, gradually incorporate the remainder of the Yellow Soft Paraffin and mix.

Compound Benzoic Acid Ointment B.P. 1999 Whitfield’s Ointment

Definition Compound Benzoic Acid Ointment contains 6.0% w/w of Benzoic Acid and 3.0% w/w of Salicylic Acid in a suitable emulsifying basis.


Benzoic Acid, in fine powder 60 gSalicylic Acid, in fine powder 30 g*Emulsifying Ointment 910 g*Emulsifying Wax (300 g) 273 g*White Soft Paraffin (500 g) 455 g*Liquid Paraffin (200 g) 182 g

1 Kg

Triturate the Benzoic Acid and the Salicylic Acid with a portion of the Emulsifying Ointment until smooth and gradually incorporate the remainder of the Emulsifying Ointment.

Compound Mercury Ointment B.P.C. 1959Scott’s Dressing


Strong Mercury Ointment 40 gYellow Beeswax 24 gArachis Oil 24 gCamphor 12 g

It contains 11 to 13% of Hg

Reference: Martindale 26th Edition

Dilute Mercury Ointment B.P.C. 1959Blue Ointment; Mercurial Ointment; Mercury Ointment


Strong Mercury Ointment 33.33 gSimple Ointment 66.67 g

It contains 9 to 11% of Hg


Emulsifying Ointment B.P. 1999

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Definition

Emulsifying Wax 300 gWhite Soft Paraffin 500 gLiquid Paraffin 200 g

Extemporaneous preparation The following directions apply.Melt together and stir until cold.

Hydrophilic Ointment U.S.P.Extemporaneous preparation Prepare Hydrophilic Ointment as follows.

White Petrolatum 250 gStearyl Alcohol 250 gPropylene Glycol 120 gSodium Lauryl Sulfate 10 gMethylparaben 0.25 gPropylparaben 0.15 gPurified Water 370 g

To make about 1000 g

*Japanese Pharmacopoeia has ethyl hydroxybenzoate 25 mg in place of methyl hydroxybenzoate.

Melt the Stearyl Alcohol and the White Petrolatum on a steam bath, and warm to about 750. Add the other ingredients, previously dissolved in the water and warmed to 750, and stir the mixture until congeals.

Packaging and Storage Preserve in tight containers.

Hydrophilic Petrolatum U.S.P. (Jap., P.)Extemporaneous preparation Prepare Hydrophilic Petrolatum as follows:

Cholesterol 30 gStearyl Alcohol 30 gWhite Wax 80 gWhite Petrolatum 860 g

To make 1000 g

Melt the Stearyl Alcohol and the White Wax together on a steam bath, then add the Cholesterol, and stir until completely dissolved. Add the White Petrolatum, and mix. Remove from the bath, and stir until the mixture congeals.

Hydrous Ointment B.P. 1999 Oily Cream; Eucerin Hydrous

Definition

Wool Alcohols Ointment 500 gPhenoxyethanol 10 gDried Magnesium Sulphate 5 gPurified Water, freshly boiled and cooled,


In preparing Hydrous Ointment the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin used to make the Wool Alcohols Ointment may be varied to produce Hydrous Ointment having suitable properties. When Hydrous Ointment is used in a white ointment, it should be prepared from Wool Alcohols Ointment made with White Soft Paraffin; when used in a coloured ointment, it should be prepared from Wool Alcohols Ointment made with Yellow Soft Paraffin.


Dissolve the Phenoxyethanol and the Dried Magnesium Sulphate in sufficient warm Purified Water to produce about 500 g. Melt the Wool Alcohols Ointment and heat to about 60°; gradually add the aqueous solution at about 60° with vigorous stirring until a smooth cream is obtained. Stir until cool, add sufficient Purified Water to produce 1000 g and mix.

Storage Hydrous Ointment should be kept in a container made from non-absorbent material. If, on storage, some aqueous liquid separates, it is readily reincorporated by stirring.

Ichthammol Ointment U.S.P.Definition Ichthammol Ointment contains an amount of Ichthammol equivalent to not less than 0.25 percent of ammonia (NH3).


Ichthammol 100 gLanolin 100 gPetrolatum 800 g

To make 1000 g

Thoroughly incorporate the Ichthammol with the Lanolin, and combine this mixture with the Petrolatum.

Packaging and Storage Preserve in collapsible tubes or in tight containers, and avoid prolonged exposure to temperature exceeding 300.

Iodine Ointment BPC 1949, non-stain (Non-staining Ointment of Iodine)Unguentum Iodi Denigrescens (Ung. Iod. Denig.)


Iodine 50 gArachis Oil 150 mlYellow Soft Paraffin to 1000 g

Mix the iodine with the arachis oil, add the yellow soft paraffin, and heat gently with occasional stirring at a temperature not excedding 600 until complete combination is effected, as indicated by the disappearance of the brown colour.

Standard.Content of total iodine: 4.75 to 5.25 percent w/w, calculated as I.

Iodine Ointment with Methyl Salicylate BPC 1949, non-stain (Non-staining Ointment of Iodine with Methyl Salicylate)Unguentum Iodi Denigrescens cum Methylis Salicylate(Ung. Iod. Denig. C. Methyl. Salicyl.)


Methyl Salicylate 50 mlNon-staining Ointment of Iodine to 1000 g

Melt the non-staining ointment of iodine, at a low temperature, add the methyl salicylate and stir until cold.

Standard.Content of total iodine: 4.29 to 5.24 percent w/w, calculated as I.

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Macrogol Ointment B.P. 1999 Definition

Macrogol 4000 350 gMacrogol 300 650 g


Add the Macrogol 4000 to the Macrogol 300, warm until homogeneous and stir continuously until cold.

Menthol and Eucalyptus Ointment B.N.F. 1963Definition

Menthol 1 gEucalyptus Oil 4 mlYellow Soft Paraffin ad 100 g

Menthol BalsamUnguentum Mantholi Compositum (Dan. Disp.)

Definition

Menthol 10 gCamphor 10 gMethyl Salicylate 25 gWhite Beeswax 18 gWool Fat 37 g

100 g

Methyl Salicylate Ointment B.P. 1999 Strong Methyl Salicylate Ointment

Definition Methyl Salicylate Ointment contains 50% w/w of Methyl Salicylate in a suitable water-emulsifying basis.


Methyl Salicylate 500 gWhite Beeswax 250 gHydrous Wool Fat 250 g

Melt together the White Beeswax and the Hydrous Wool Fat, cool, add the Methyl Salicylate and stir until cold.

Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment.

Methyl Salicylate Ointment, Compound B.P.C. 1973Syn. Analgesic Balm; Unguentum Methylis Salicylatis Compositum Forte

Definition Methyl Salicylate Ointment contains 50% w/w of Methyl Salicylate in a suitable water-emulsifying basis.


Methyl Salicylate 500 gCajuput Oil 25 mlCineole 25 mlWater for preparations 45 mlMenthol 100 gWool Fat 105 gWhite Beeswax 200 g

Melt together the White Beeswax and the Wool Fat and add the Menthol previously dissolved in the Methyl Salicylate, the Cineole, and the Cajuput Oil. Incorporate the Water at the same temperature, and stir until cold. stir until cold.

A standard for this ointment is given in the British Pharmaceutical Codex 1973.

Storage Containers should prevent evaporation. Certain plastic containers, such as those made from polystyrene, are unsuitable for use with this ointment.

Advice for patients The ointment should be massaged well into the skin. It should not be applied to broken or inflamed skin or near to the eyes or mucous membranes. The container should be kept tightly closed.

Oleated Mercury B.P.C. 1959 (stab.) Hydrargyrum Oleatum; Hydrarg. Oleat.; Mercury Oleate


Yellow Mercuric Oxide 20%Liquid Paraffin 5%Oleic Acid 75%

Triturate the Yellow Mercuric Oxide with Liquid Paraffin, the mixed with Oleic Acid and heated at 50O until combination is effected.

Foreign Pharmacopoeias: In Chin. And Ind. (as B.P.C. 1959); in Braz. And Mex. (both 25% HgO).

A yellowish unctuous. Insoluble in water; slightly soluble in alcohol and ether; readily soluble in fixed oils. Protect from light. It may be employed in ointment form for uses similar to those of ammoniated mercury.

Preparations:Oleated Mecury Ointment B.P. 1953 (Ung. Hydrarg. Oleat.)Oleated Mercury 25%Simple Ointment to 100%

It contains 5% of HgO. Store in a cool place. Protect from light.

Bralium Forte (Hefa, Ger.: Grabowski) An oily lotion containing oleated mercury equivalent to 2 and 5% of mercury. For psoriasis.


Paraffin Ointment B.P. 1999; BNFDefinition

White Beeswax 20 gHard Paraffin 30 gCetostearyl Alcohol 50 gWhite Soft Paraffin 900 g


Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.

Salicylic Acid and Sulphur Ointment B.P.C. 1973Extemporaneous preparation

Salicylic acid, finely sifted 30 gPrecipitated sulphur, finely sifted 30 gOily Cream 940 g

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Triturate the salicylic acid and the precipitated sulphur with a portion of the oily cream until smooth and gradually incorporate the remainder of the cream.

Advice for patients: The ointment should be applied sparingly to the affected area. It should not be applied to broken or inflamed skin; contact with the eyes should be avoided. Prolonged use should be avoided and treatment should be discontinued if excessive dryness or irritation occurs.

A standard for this ointment is given in the British Pharmaceutical Codex 1973.

Salicylic Acid 6% and Urea 10% in Petrolatum Extemporaneous preparation

Salicylic Acid, fine powder 60 gUrea 100 gWater 120 mlPetrolatum (Eucerin) 720 g

1 Kg

Salicylic Acid Ointment B.P. 1999 Definition Salicylic Acid Ointment contains 2% w/w of Salicylic Acid in a suitable water-emulsifyingbasis.


Salicylic Acid, finely sifted 20 gWool Alcohols Ointment 980 g

Melt the Wool Alcohols Ointment, gradually add the Salicylic Acid and stir until cold.

Used in acne, eczema, and ringworm

Simple Ointment B.P. 1999 Definition

Wool Fat 50 gHard Paraffin 50 gCetostearyl Alcohol 50 gWhite Soft Paraffin or Yellow Soft Paraffin 850 g

Unless otherwise directed in the monograph, when Simple Ointment is used in a white ointment, it should be prepared with White Soft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin.


Mix the ingredients, heat gently with stirring until homogeneous and stir until cold.

Starch Glycerite USNFDefinition

Starch (Potato) 100 gBenzoic Acid 2 gPurified Water 200 mlGlycerin 700 ml To make about 1000 g


Rub the starch and the benzoic acid with the purified water in a porcelain dish until a smooth mixture is produced, then add the glycerin, and mix well. Heat the mixture on a sand bath to a temperature between 140O and 144O, with constant but gentle stirring until a translucent, jelly-like mass results, and then strain through muslin. Starch Glycerite should be freshly prepared.

Uses Although not an oleaginous base, this emollient preparation is sometimes used as a substitute for a fatty ointment. It has also been used as a pill excipient.

Dose For external use, topically as required.

Storage Store in airtight container.

Ref: Rimington’s Pharmaceutical Sciences – 16th Edition page-1249Martindale:

Preparation:

Salicylic Acid 6% in Starch Glycerite USNF

Salicylic Acid 6% 96 gStarch (Potato) 112 gBenzoic Acid 2 gPurified Water 190 gGlycerin 700 gEucerin 500 g To make about 1600 g

Strong Mercury Ointment B.P.C. 1959Ung. Hydrarg. Fort.: Unguentum Hydrargyrum Cinereum


Mercury 30 gOleated Mercury 1.5 gWool Fat 43 gWhite Beeswax 7 gWhite Soft Paraffin 18.5 g

A similar ointment, usually with the title Unguentum Hydrargyri, is included in many pahramacopoeias.

Dilute Mercury Ointment B.P.C. 1959Ung. Hydrarg. Dil..; Blue Ointment; Mercurial Ointment; Mercury Ointment


Strong Mercury Ointment 33.33 gSimple Ointment 66.67 g

It contains 9 to 11% of Hg.

Sulphur Ointment B.P. 1980


Precipitated Sulphur, finely sifted 100 gSimple Ointment prepared with White Soft Paraffin 900 g

Triturate the Precipitated Sulphur with a portion of the Simple Ointment until smooth, gradually add the remainder of the Simple Ointment, and mix thoroughly.

Contents of sulphur, S 9.5 to 10.5 percent w/w.

Note: Uses of Sulfur precipitated – An active parasiticide; a 10% sulfur paste or ointment is used as an alternative

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treatment for Sarcoptes scabiei (mites). Sulfur also is actively keratolytic and, in the form of full-strength ointment or in combination with other keratolytic agents such as psoriasis, seborrhea, eczema-dermatitis and lupus erythematosus. The percentage of sulfur in an ointment should be reduced in the event that a patient's skin shows intolerance. Prolonged use of sulfur may result in a characteristic dermatitis venerate.Dose - Topical, as a 10% ointment every night for 3 nights.

Sulphur Ointment U.S.P. 1995Definition Suffur Ointment contains not less than 9.5 percent and not more than 10.5 percent of S.


Precipitated Sulfur 100 gMineral Oil 100 gWhite Ointment 800 g To make 1000 g

Levigate the sulfur with the Mineral Oil to a smooth paste, and then incorporate with the White Ointment.

Packaging and Storage Preserve in well-closed containers, and avoid prolonged exposure to excessive heat.

Wool Alcohols Ointment B.P. 1999 Definition

Wool Alcohols 60 gHard Paraffin 240 gWhite Soft Paraffin or Yellow Soft Paraffin 100 gLiquid Paraffin 600 g

In preparing Wool Alcohols Ointment, the proportions of Hard Paraffin, Soft Paraffin and Liquid Paraffin may be varied to produce Wool Alcohols Ointment having suitable properties. When Wool Alcohols Ointment is used in a white ointment, it should be prepared with WhiteSoft Paraffin; when used in a coloured ointment it should be prepared with Yellow Soft Paraffin.


Melt together with the aid of gentle heat and stir until cold.

Zinc and Castor Oil Ointment B.P. 1999 Zinc and Castor Oil Cream

Definition

Zinc Oxide, finely sifted 75 gCastor Oil 500 gCetostearyl Alcohol 20 gWhite Beeswax 100 gArachis Oil 305 g


Triturate the Zinc Oxide with a portion of the Castor Oil until smooth and add the mixture to the remainder of the ingredients previously melted together. Stir while cooling until the temperature is about 40°.

Zinc Oxide Ointment B.P. 1999

Definition Zinc Ointment contains 15% w/w of Zinc Oxide in a suitable water-emulsifying basis.


Zinc Oxide, finely sifted 150 gSimple Ointment 850 g

*Simple Ointment B.P. 1999*Wool Fat (5%)*Hard Paraffin (5%)*Cetostearyl Alcohol (5%)*White Soft Paraffin (85%)

Triturate the Zinc Oxide with a portion of the Simple Ointment until smooth, gradually add theremainder of the Simple Ointment and mix thoroughly.

PAINTS:

Castellani’s Paint B.P.C. 1973Synonyms: Fuchsine Paints; Magenta Paint

Magenta 4 gBoric Acid 8 gPhenol 40 gResorcinol 80 gAcetone 40 mlAlcohol (90 per cent) 85 mlWater (see page 642) to 1 L

Dissolve the magenta in the alcohol and the acetone, previously mixed. Dissolve the boric acid in a portion of water; dissolve the phenol and the resorcinol in this solution, add the alcoholic magenta solution and sufficient water to produce the required volume, and mix.

In making this preparation the alcohol (90 per cent) may be replaced by Industrial Methylated Spirit diluted so as to be of equivalent alcoholic strength, provided that the law and the statutory regulations governing the use of industrial methylated spirit are observed.

Storage. It should be stored in airtight containers, protected from light, in a cool place.

Compound Iodine Paint B.P.C. 1968Mandl's Paint

Definition

Iodine 1.25 gPotassium Iodide 2.50 gWater 2.50 mlPeppermint Oil 0.40 mlAlcohol 90% 4.00 mlGlycerol ad 100 ml

It should be well shaken before use.Store in a cool place in airtight containers.It is used as a throat paint in the treatment of pharyngitis and follicular tonsillitis.

Compound Podophyllin Paint B.P. 1999 Definition Compound Podophyllin Paint is a cutaneous solution.

Podophyllum Resin 150 gCompound Benzoin Tincture

14


In making the Compound Benzoin Tincture used to prepare Compound Podophyllin Paint, the Ethanol (90 per cent) may be replaced by Industrial Methylated Spirit 1

diluted so as to be of equivalent ethanolic strength.

Labelling The label indicates the pharmaceutical form as ‘cutaneous solution’.

1 The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.

Dental Iodine Paint Jap. Ph.Dental Iodine Solution


Iodine 100 gPotassium Iodide 80 gZinc Sulphate 10 gGlycerol 350 mlWater to 1000 ml

Gentian Violet Paint B.P.C. 1973Crystal Violet Paint

Crystal Violet 0.5 gWater 100 ml

Dissolve

Crystal Violet: (Hexamethylpararosaniline hydrochloride)

A 0.5% aqueous solution is applied topically in the treatment of candidal infections of the mouth, boils, chronic ulcers, and mycotic skin affections and a solution containing 0.5% of crystal violet and 0.5% of brilliant green has been used for pre-operative skin disinfectant. It has been used as cream and pessaries for vaginal infections.

Crystal violet was formerly used in the treatment of strongloid and threadworm infections. A form of crystal violet is used for marking raw and unprocessed meat and citrus fruits.

Containers; Labelling; Storage. The directions given under Paints (page 765) should be followed.

Gentian Violet Paint U.S.P.Crystal Violet Paint


Gentian Violet 1 gAlcohol absolute 8 mlWater to 100 ml

Store in airtight container.

Mercurochrome Paints B.P.C.Merbromin; Mercurodibromo-flourescein; Mercuresceine Sodique. It consists chiefly of disodium 2,7-dibromo-4-hydroxymercurifluorescein


Mercurochrome 2 gWater ad 100 ml

Uses and administration Mercurochrome is a weak disinfectant; in the presence of organic material its effect is greatly reduced. It is non-irritant to tissues but has poor

penetrating power. Aqueous solutions are of little value for skin disinfectantion but a 2% solution in a mixture of alcohol, acetone, and water has been used. Mercurochrome has also been applied as a surface disinfectant to mucous membranes and wounds but is unreliable. In genito-urinary infections mercurochrome has been used as a 1% solution for bladder and urethral irrigation. Stains on the skin caused by mercurochrome may be removed with chlorinated soda solution.Mercurochrome is a weak mercurial antiseptic that has been used for disinfection of skin and wounds.

Talbot Iodine PaintExtemporaneous preparation The following formula and directions apply.

Iodine 25 gZinc Iodide 22 gWater 10 mlGlycerin ad 100 ml

Talbot Iodine Paint, Dilute (2%)Extemporaneous preparation The following formula and directions apply.

Talbot Iodine Paint 80 mlGlycerin ad 1000 ml

PASTES:

Bismuth Subnitrate and Iodoform Paste B.P.C. 1954 Definition

Bismuth Subnitrate 1 g 250 gIodoform 2 g 500 gLiquid Paraffin, previously heated at 1500C for one hour and cooled 1 g 250 g

1 Kg


Triturate the Bismuth Subnitrate and the Iodoform in a sterile mortar with sufficient of the Liquid Paraffin to produce a smooth paste, using aseptic precautions; transfer the remainder of the Liquid Paraffin, and mix.

Storage It should be stored in sterilized collapsible tubes, in a cool place.

Compound Aluminium Paste B.P. 1999Baltimore Paste

Definition Compound Aluminium Paste contains 20% w/w of Aluminium Powder and 40% w/w of Zinc Oxide in a suitable hydrophobic liquid basis.


Aluminium Powder 200 gZinc Oxide 400 gLiquid Paraffin 400 g

Mix the Aluminium Powder and the Zinc Oxide with the Liquid Paraffin until smooth.

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Coal Tar Paste B.P. 1999 Definition

Strong Coal Tar Solution 75 gCompound Zinc Paste 925 g


Triturate the Strong Coal Tar Solution with a portion of the Compound Zinc Paste until smooth and gradually incorporate the remainder of the Compound Zinc Paste.

Compound Zinc Paste B.P. 1999 Definition Compound Zinc Paste contains 25% w/w each of Zinc Oxide and Starch in a suitable hydrophobic basis.


Zinc Oxide, finely sifted 250 gStarch, finely sifted 250 gWhite Soft Paraffin 500 g

Melt the White Soft Paraffin, incorporate the Zinc Oxide and the Starch and stir until cold.

Dithranol Paste B.P. 1993 Definition Dithranol Paste contains Dithranol in a suitable hydrophobic basis containing 24% w/w each of Zinc Oxide and Starch and 2% w/w of Salicylic Acid.


Dithranol 1 g, or a sufficient quantityZinc and Salicylic Acid Paste sufficient to produce 100 g

* Zinc and Salicylic Acid Paste (Lassar's Paste)* Zinc Oxide 240 g* Salicylic Acid 20 g* Starch 240 g* White Soft Paraffin 500 g

Mix the Dithranol with a portion of the Zinc and Salicylic Acid Paste until a smooth, even dispersion is obtained and gradually incorporate the remainder of the Zinc and Salicylic Acid Paste.

Magnesium Sulphate Paste B.P. 1999 Morison’s Paste

Definition

Dried Magnesium Sulphate a sufficient quantityPhenol 0.5 gGlycerol, previously heated at 120° for 1 hour

and cooled 55 g


Dry about 70 g of Dried Magnesium Sulphate at 150° for 1.5 hours or at 130° for 4 hours and allow to cool in a desiccator. Mix 45 g of the dried material in a warm mortar with the Phenol dissolved in the Glycerol.In preparing larger quantities of the paste the period of heating the Dried Magnesium Sulphate should be increased, if necessary, to ensure that the dried material contains not less than 85% of magnesium sulphate, calculated as MgSO 4 .

Storage Magnesium Sulphate Paste should be kept in a well-closed container.

Labelling The label states that the Paste should be stirred before use.

Zinc and Coal Zinc Paste B.P. 1999 White’s Tar Paste

Definition Zinc and Coal Tar Paste contains 6% w/w each of Zinc Oxide and Coal Tar with 38% w/w of Starch in a suitable hydrophobic basis.


Emulsifying Wax 50 gCoal Tar 60 gZinc Oxide, finely sifted 60 gStarch 380 gYellow Soft Paraffin 450 g

Melt the Emulsifying Wax at 70°, add the Coal Tar and 225 g of the Yellow Soft Paraffin, stir at 70° until completely melted, add the remainder of the Yellow Soft Paraffin, cool to 30°, add the Zinc Oxide and the Starch, stirring constantly, and stir until cold.

Zinc and Salicylic Acid Paste B.P. 1999 Lassar’s Paste

Definition

Zinc Oxide, finely sifted 240 gSalicylic Acid, finely sifted 20 gStarch, finely sifted 240 gWhite Soft Paraffin 500 g

Extemporaneous preparation The following directions apply.Melt the White Soft Paraffin, incorporate the Zinc Oxide, the Salicylic Acid and the Starch and stir until cold.

POULTICES :

Kaolin Poultice B.P. 1999 Definition

Heavy Kaolin 1 , finely sifted 527 gBoric Acid, finely sifted 45 gMethyl Salicylate 2 mlThymol 500 mgPeppermint Oil 0.5 mlGlycerol 425 g


Mix the Heavy Kaolin, previously dried at 100°, and the Boric Acid with the Glycerol, heat at 120° for 1 hour, stirring occasionally, and allow to cool. Separately, dissolve the Thymol in the Methyl Salicylate, add to the cooled mixture, add the Peppermint Oil and mix thoroughly. The heating step may be omitted if some other satisfactory means of mixing the solid ingredients with the Glycerol is used but in this case Heavy Kaolin that has been sterilised is used.

Storage Kaolin Poultice should be kept in suitable containers that minimise absorption, diffusion or evaporation of the ingredients.

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1 If an appropriate heating step, such as that described under Extemporaneous preparation, is not included in the manufacturing process, Heavy Kaolin that has been sterilised is used.

SOLUTIONS :

Aluminium Chloride Solution BP 2005

DEFINITION Aluminium Chloride Solution is a cutaneous solution. It contains Aluminium Chloride Hexahydrate in a suitable ethanolic vehicle. PRODUCTION In making Aluminium Chloride Solution, Industrial Methylated Spirits may be used provided that the law and the statutory regulations governing the use of Industrial Methylated Spirits are observed. Content of aluminium chloride hexahydrate, AlCl3,6H2O 95.0 to 105.0% of the stated amount. STORAGE Aluminium Chloride Solution should be stored upright.

LABELLING The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored; (3) that the solution is flammable.

Aluminium Chloride Solution Definition

Aluminium Chloride 6000 gGlycerin 7500 gEthanol absolute to 30 LT

Aqueous Iodine Oral Solution B.P. 1999 Definition

Iodine 50 gPotassium Iodide 100 gPurified Water, freshly boiled and cooled


Extemporaneous preparation The following directions apply.Dissolve the Potassium Iodide and the Iodine in 100 ml of the Purified Water and add sufficient of the Purified Water to produce 1000 ml.

Storage Aqueous Iodine Oral Solution should be kept in a well-closed container, the materials of which are resistant to iodine.

Labelling The label states that the solution should be well diluted before use.Aqueous Iodine Oral Solution contains in 1 ml 50 mg of Iodine and about 130 mg of total iodine, free and combined. Aqueous Iodine Oral Solution is intended to be diluted before use. When aqueous iodine solution is prescribed or demanded, Aqueous Iodine Oral Solution shall be dispensed or supplied.

Aromatic Ammonia Solution B.P. 1999 Sal Volatile Solution

Definition

Ammonium Bicarbonate 25 gNutmeg Oil 0.3 mlLemon Oil 0.5 mlEthanol (90 per cent) 37.5 mlStrong Ammonia Solution 67.5 mlPurified Water, freshly boiled and cooled


Extemporaneous preparation The following directions apply.Dissolve the Ammonium Bicarbonate in 800 ml of the Purified Water. Separately dissolve the Lemon Oil and the Nutmeg Oil in the Ethanol (90 per cent). Add the ethanolic solution to the aqueous solution and add the Strong Ammonia Solution and sufficient Purified Water to produce1000 ml. Add 25 g of previously sterilised Purified Talc, shake, allow to stand for a few hours, shaking occasionally, and filter.

Storage Aromatic Ammonia Solution should be kept in a well-closed container and stored at a temperature not exceeding 25°.

Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.

Dilute Ammonia Solution B.P. 1999 Definition Dilute Ammonia Solution contains 10% w/w of ammonia. It is prepared by diluting Strong Ammonia Solution with freshly boiled and cooled Purified Water.

Storage Dilute Ammonia Solution should be kept in a well-closed container.

Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.When ammonia solution is prescribed or demanded, Dilute Ammonia Solution shall be dispensed or supplied.

Benzoic Acid Solution B.P. 1993 Definition

Benzoic Acid 50 gPropylene Glycol 750 mlPurified Water, freshly boiled and cooled



Dissolve the Benzoic Acid in the Propylene Glycol and add sufficient Purified Water, in small quantities and with constant stirring, to produce 1000 ml.

Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions

under which it should be stored.:

Calcium Hydroxide Solution B.P. 1999 Lime Water

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Definition

Calcium Hydroxide 10 gPurified Water, freshly boiled and cooled

Sufficient to produce 1000 ml


Shake together thoroughly and repeatedly; allow to stand until clear. Siphon off the clear solution as required.

Storage Calcium Hydroxide Solution should be kept in a well-filled and well-closed container.


Cetrimide Solution B.P. 1999 Definition Cetrimide Solution is a 1% w/v cutaneous solution of cetrimide prepared by appropriately diluting Strong Cetrimide Solution with Purified Water. Cetrimide Solution is freshly prepared.

Labelling The label states that the solution should not be used later than 1 week after the container is first opened. The label indicates the pharmaceutical form as ‘cutaneous solution’.

Coal Tar Solution B.P. 1999 Definition

Coal Tar 200 gPolysorbate 80 50 gEthanol (96 per cent) sufficient to produce 1000 ml

In making Coal Tar Solution, the Ethanol (96 per cent) may be replaced by Industrial MethylatedSpirit 1 .


Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 800 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allowthe mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml.

Storage Coal Tar Solution should be kept in a well-closed container.


1 The law and the statutory regulations governing the use of Industrial Methylated Spirit must be observed.

Coal Tar Solution B.P. 1999, Strong Definition

Coal Tar 400 gPolysorbate 80 50 gEthanol (96 per cent) sufficient to produce 1000 ml

In making Strong Coal Tar Solution the Ethanol (96 per cent) may be replaced by Industrial Methylated Spirit 1 .


Mix the Coal Tar, warmed if necessary to render it fluid, with the Polysorbate 80, pour this mixture in a thin stream into 700 ml of Ethanol (96 per cent) in a closed vessel fitted with an agitator; continue agitation throughout the addition of the mixture and for 1 hour thereafter. Allowthe mixture to stand for not less than 24 hours, decant and filter the supernatant liquid, wash the vessel and filter with Ethanol (96 per cent), combine the filtrate and washings and add sufficient Ethanol (96 per cent) to produce 1000 ml.

Jessner’s Solution Definition

Resorcinol 14 gSalicylic Acid 14 gLactic Acid 14 mlEthanol (95 per cent) sufficient to produce 100 ml


Dissolve the Resorcinol in a portion of water, dissolve separately the remainder items in alcohol and mix the two solutions and filter.

Joulie’s Solution Phosphate Mixture

Definition

Sodium Phosphate 136 gPhosphoric Acid 85% 58.8 gPurified Water, freshly boiled and cooled


Extemporaneous preparation Dissove.

The solution has a pH of 4.9, contains 1725 millios- moles per litre, and provides 30.4 mg of inorganic phosphorus per ml.

Dose 15 ml every 4 hours, 5 times daily.

Lead Subacetate Solution, Dilute B.P.C. 1973Synonym: Liquor Plumbi Subacetatis Dilutus

Definition

Strong Lead Subacetate Solution 12.5 mlPurified Water, freshly boiled and

cooled to 1000 ml

Lead Subacetate Solution, Strong B.P.C. 1973Synonym: Liquor Plumbi Subacetatis Fortis

Definition

Lead Monoxide, in powder 175 gLead Acetate 250 gPurified Water, freshly boiled and

cooled to 1000 ml

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Extemporaneous preparation Dissolve the lead acetate in 750 ml of the water, add the lead monoxide, and allow to stand for forty-eight hours, shaking occasionally, filter, pass through the filter sufficient of the water to produce the required volume, and mix.

Povidone Iodine Surgical Scrub Solution Definition

A detergent solution for surgical disinfection containing 7.5% percent Povidone-Iodine equivalent to 0.75% available Iodine.

Povidone Iodine Topical Solution U.S.P. Definition

Povidone Iodine 100 g(Sodium Bicarbonate- as preservative) 20 gPurified Water sufficient to produce 1000 ml


Dissolve.

Sodium Chloride Solution B.P. 1999 Definition Sodium Chloride Solution is a 0.9% w/v cutaneous solution of Sodium Chloride in Purified Water. The solution may be clarified by filtration.

Labelling The label states, where applicable, that the contents of the container are sterile. The label indicates the pharmaceutical form as ‘cutaneous solution’. When normal saline is prescribed or demanded, Sodium Chloride Solution shall be dispensed or supplied.

If the label states that the contents of the container are sterile, the solution complies with the following additional requirements.

Sterility Complies with the test for sterility, Appendix XVI A.

Labelling The label states (1) ‘Sterile Sodium Chloride Solution’; (2) that the solution is not intended for injection; (3) the date after which the solution is not intended to be used; (4) the conditions under which it should be stored.

SPIRITS:

Aromatic Ammonia Spirit B.P. 1999 Sal Volatile Spirit

Definition

Nutmeg Oil 3 mlLemon Oil 5 mlEthanol (90 per cent) 750 mlAmmonium Bicarbonate 25 gStrong Ammonia Solution 67.5 mlPurified Water sufficient to produce 1000 ml


Distil a mixture of the Lemon Oil, the Nutmeg Oil, the Ethanol (90 per cent) and 375 ml of Purified Water. Reserve the first 875 ml of distillate. Distil a further 55 ml

and add the Ammonium Bicarbonate and the Strong Ammonia Solution to the distillate. Heat on a water bath to 60° in a sealed bottle of not less than 120-ml capacity, shaking occasionally, until solution is complete, cool, filter through absorbent cotton, mix the filtrate with the reserved distillate, add sufficient Purified Water to produce 1000 ml and mix.

Chloroform Spirit B.P. 1999Definition

Chloroform 50 mlEthanol (90 per cent) sufficient to produce 1000 ml

Colongne SpiritSpiritus Colonieses (Sp. Colon.) / Aqua Colonieses

Definition

Oil of Bergamot 12.5 mlOil of Lemon 5.0 mlOil of Neroli 2.0 mlOil of Rosemary 1.5 mlOil of Thyme 0.5 mlConcentrated Orange-flower Water 3.0 mlWater 41.7 mlAlcohol (90 percent) to 1000 ml


Dissolve the oils in about 900 ml of the alcohol 90 percent, add gradually the concentrated orange-flower water, previously diluted with water, and then add sufficient alcohol 90 percent to produce the required volume.

In making this preparation the alcohol 90 percent may be replaced by industrial methylated spirit diluted so as to be of equivalent alcoholic strength , provided that the final product contains 1 percent. v/v of ethyl phthalate and that the law and the statutory regulations governing the use of industrial methylated spirit are observed.

Reference: Pharmacopoeia ___________________Formulary page 1285

Compound Orange Spirit B.P. 1999 Definition

Terpeneless Orange Oil 2.5 mlTerpeneless Lemon Oil 1.3 mlAnise Oil 4.25 mlCoriander Oil 6.25 mlEthanol (90 per cent) sufficient to produce 1000 ml

Lemon Spirit B.P. 1999 Definition

Terpeneless Lemon Oil 100 mlEthanol (96 per cent) sufficient to produce 1000 ml

Peppermint Spirit B.P. 1999 (B.P., A.P.F.) Peppermint Essence

Definition

Peppermint Oil 100 ml

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Ethanol (90 per cent) sufficient to produce 1000 ml


Dissolve the Peppermint Oil in Ethanol (90 per cent) and add sufficient Ethanol (90 per cent) to produce 1000 ml. If the solution is not clear, shake with previously sterilised Purified Talc and filter.

Surgical Spirit B.P. 1999 Definition

Methyl Salicylate 5 mlDiethyl Phthalate 20 mlCastor Oil 25 mlIndustrial Methylated Spirit sufficient to produce 1000 ml

Labelling The label states that the preparation is flammable and should be kept away from a naked flame.

SYRUPS:

Syrup B.P. 1999 Definition

Sucrose 667 gPurified Water sufficient to produce 1000 g

One or more suitable antimicrobial preservatives may be added.


Heat together until dissolved and add sufficient boiling Purified Water to produce 1000 g.

Labelling The label states the names and proportions of any added antimicrobial preservatives. When antimicrobial preservatives are added the suitability of the Syrup as a vehicle or diluent should be confirmed before use. The pH of Syrup may affect the solubility of basic or acidicmaterials.

Aromatic Castor Oil U.S.P.Definition

Cinnamon Oil USNF 0.3 mlClove Oil 0.1 mlSaccharin 50 mgVanillin 100 mgAlcohol 3 mlCastor Oil ad 100 ml


Black Currant Syrup B.P. 1999 Definition Black Currant Syrup is prepared either from the clarified juice of Black Currant or from concentrated black currant juice of commerce. It contains a suitable antioxidant. Permittedfood grade colours may be added.

Production It is prepared by dissolving 700 g of Sucrose either in 560 ml of clarified juice, previously diluted with Water to a weight per ml of 1.045 g, or in 560 ml of a solution of the same weight per ml prepared from the

concentrated juice of commerce and Water, and adding to this solution sufficient Benzoic Acid to give a final concentration of not more than 800 ppm, or suffi-cient Sodium Metabisulphite or other suitable sulphite to give a final concentration of not more than 350 ppm of sulphur dioxide.

Storage Black Currant Syrup should be kept in a well-filled, well-closed container, protected from light and stored at a temperature not exceeding 25°. Black Currant Syrup contains, in 10 ml, about 7.5 mg of ascorbic acid.1 The requirement for Content of ascorbic acid does not apply when Black Currant Syrup is used as a flavouring agent for pharmaceutical purposes.

Invert Syrup B.P. 1999 Definition Invert Syrup is a mixture of glucose and fructose prepared by hydrolysing a 66.7% w/w solution of Sucrose with a suitable mineral acid, such as hydrochloric acid, and neutralising the resulting solution using, for example, calcium carbonate or sodium carbonate. The degree of inversion is at least 95%.

Storage Invert Syrup should be stored at a temperature of 35° to 45°.

Ipecacuanha Syrup (Emetic) A.P.F. Definition Ipecacuanha liquid extract 6 mlDilute acetic acid 2.5 mlGlycerol 10 mlSyrups to 100 ml

Dosechildren under 2 years 15 ml 2 to 3 years 20 ml 3 to 4 years 25 ml

*Contains 0.12% w/v total alkaloids calculated as emetine.The dose should be followed by a tumblerful of water and if there is no response after 20 minutes, a further dose and a tumblerful of water should be given.

To be administered only under medical supervision.

Reference: Martindale Extra Pharmacopoeia 29th Edition

Lemon Syrup B.P. 1999 Definition

Lemon Spirit 5 mlCitric Acid Monohydrate 25 gmInvert Syrup 100 mlSyrup sufficient to produce 1000 ml

Extemporaneous preparation The following directions apply.Dissolve the Citric Acid Monohydrate in some of the Syrup, add the Invert Syrup, the Lemon Spirit and sufficient Syrup to produce 1000 ml and mix.

Storage Lemon Syrup should be stored at a temperature not exceeding 25°.

Orange Syrup B.P. 1999 Definition

Orange Tincture 60 mlSyrup sufficient to produce 1000 ml

Potassium Syrups (1)

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Potassium Chloride 4.00 gPotassium Gluconate 10.86 gSodium Benzoate 0.10 gGlycerin 10.00 mlBlack Currant Syrup 10.00 mlSimple Syrup 25.00 mlDistilled Water ad 100.00 ml

Potassium Syrups (2)Potassium Chloride 4.00 gPotassium Gluconate 10.86 gSodium Benzoate 0.10 gWater 10.00 mlGlycerin 10.00 mlBlack Currant Syrup 10.00 mlSimple Syrup ad 100.00 ml

TINCTURES:

Compound Benzoin Tincture B.P. 1999 Friars’ Balsam

Definition

Barbados Aloes or Cape Aloes 20 gPrepared storax, of commerce 100 gSumatra Benzoin, crushed 100 gEthanol (90 per cent) sufficient to produce 1000 ml


Macerate the Barbados Aloes or Cape Aloes, the prepared storax and the Sumatra Benzoin with 800 ml of Ethanol (90 per cent) in a closed vessel for not less than 2 days, shaking occasionally, filter and pass sufficient Ethanol (90 per cent) through the filter to produce 1000 ml.

Ipecacuanha Tincture B.P. 1999 Definition

Ipecacuanha Liquid Extract 100 mlAcetic Acid (6 per cent) 16.5 mlEthanol (90 per cent) 210 mlGlycerol 200 mlPurified Water sufficient to produce 1000 ml


Mix the Ethanol (90 per cent) and the Acetic Acid (6 per cent) with the Glycerol and 450 ml of Purified Water and add the Ipecacuanha Liquid Extract and sufficient Purified Water to produce 1000 ml. Allow to stand for not less than 24 hours; filter.

Alcoholic Iodine Solution B.P. 1999 Definition Alcoholic Iodine Solution is a cutaneous solution.

Iodine 25 gPotassium Iodide 25 gPurified Water 25 mlEthanol (90 per cent) sufficient to produce 1000 ml


Dissolve the Potassium Iodide and the Iodine in the Purified Water and add sufficient Ethanol (90 per cent) to produce 1000 ml.

Labelling The label states (1) the date after which the solution is not intended to be used; (2) the conditions under which it should be stored.The label indicates the pharmaceutical form as ‘cutaneous solution’.When iodine tinture is prescribed or demanded Alcoholic Iodine Solution shall be dispensed or supplied.

Iodine Tincture B.P., 2.5%Definition

Iodine B.P. 25 gPotassium Iodide 25 gPropylene Gycol 250 mlDistilled Water 25 mlEthanol 90% 1000 ml

Orange Tincture B.P. 1999 Definition

Dried Bitter-Orange Peel, in moderately fine powder 110 gEthanol (70 per cent) a sufficient quantity

Extemporaneous preparation The following directions apply.Prepare 1000 ml of tincture by percolation, Appendix XI F.

WATERS:

Chloroform Water B.P. Definition

Chloroform 2.5 mlPurified Water, freshly boiled and cooled sufficient to produce 1000 ml

Extemporaneous preparation The following directions apply.Dissolve the Chloroform in the Purified Water by shaking.

Double-strength Chloroform Water B.P. 1999 Definition

Chloroform 5 mlPurified Water, freshly boiled and cooled



Dissolve the Chloroform in the Purified Water by shaking.

Concentrated Anise Water B.P. 1999 Definition

Anise Oil 20 mlEthanol (90 per cent) 700 mlWater sufficient to produce 1000 ml


Dissolve the Anise Oil in the Ethanol (90 per cent) and add gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml. Add 50 g of

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previously sterilised Purified Talc, or other suitable filtering aid, allow to stand for a few hours, shaking occasionally, and filter.

Concentrated Camphor Water B.P. 1999 Definition

Racemic Camphor 40 gEthanol (90 per cent) 600 mlWater sufficient to produce 1000 ml


Dissolve the Racemic Camphor in the Ethanol (90 per cent) and add, gradually, with vigorous shaking after each addition, sufficient Water to produce 1000 ml.

Concentrated Peppermint Water B.P. 1973 Definition

Peppermint Oil 2 mlEthanol (90 per cent) 60 mlWater sufficient to produce 1000 ml

Shaken with talc and filtered.. It is 40 times as strong as peppermint water.

Peppermint Water B.P. 1973 Definition

Concentrated Peppermint Water 2.5 mlWater sufficient to produce 1000 ml

Shaken with talc and filtered.. It is 40 times as strong as peppermint water.

Concentrated Rose Water B.P.C.Aqua Rose Concentrata

Definition

Oil of Rose 10 ml 48 m.Alcohol (90 per cent) 500 ml 5 fl. oz.Water to 1000 ml to 10 fl. oz.

Dissolve the oil of rose in the alcohol (90 per cent.) and add sufficient water in successive small portions to produce the required volume, shaking vigorously after each addition. Add (1/2 oz.) of purified talc, and shake; allow to stand for a few hours, occasionally shaking, and filter.

Rose water may be prepared by diluting concentrated rose water with 39 times its volume of water; the product contains about 1.25 per cent. v/v of alcohol (90 per cent.).

Triple rose water may be prepared by diluting concentrated rose water with 12 times its volume of water; the product contains about 4 per cent. v/v of alcohol (90 per cent)

WAX:

Cetomacrogol Emulsifying Wax B.P. 1999

Non-ionic Emulsifying Wax

Definition

Cetostearyl Alcohol 800 gMacrogol Cetostearyl Ether (22) 200 g


Melt together and stir until cold.

Characteristics A white or almost white, waxy solid or flakes melting when heated to a clear almost colourless liquid; odour faint and characteristic of cetostearyl alcohol. Practically insoluble in water, producing an emulsion; moderately soluble in ethanol (96%); partlysoluble in ether.

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100404 Amro Damanhoury

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