synthesis and semi synthesis of proteins

7
Protein Engineering BIT317 Class 2438 Lecture 7 Synthesis and Semi-synthesis of Peptides

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synthesis and semi synthesis of proteins

Transcript of synthesis and semi synthesis of proteins

  • Protein Engineering

    BIT317 Class 2438

    Lecture 7Synthesis and Semi-synthesis of Peptides

  • Strategy inSolid Phase Peptide Synthesis

    Pioneered byMerrifield

  • Microwave Assisted Synthesis

    Reduction in synthesis timeFor peptides that contain beta sheet structures / sterically hindered couplings

  • Major Limitation of SPPS

    Feasibility for application for larger proteins

    Higher probability of misfolding

    Enhanced error rates

    Levels of purity

    Formation of disulfide bonds (disulfide scrambling)

  • Protein semisynthesis protein ligation

  • Chemoselective ligation for artificial backbone


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Site of Synthesis of Membrane and Nonmembrane Proteins of ...

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is a synthesis of premium proteins designed to give your ...€¦ · SYNTHESIS OF PROTEINS THE CUTTING EDGE IN TASTE & NUTRITION SYNTHA-6 EDGE® is a synthesis of premium proteins

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