Reseptor Adrenergik

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Reseptor Adrenergik


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The adrenergic receptors(or adrenoceptors)are a class of G protein-coupled receptorsthat

are targets of the catecholamines, especially

norepinephrine(noradrenaline) and epinephrine

(adrenaline).

www.themegallery.com
http://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/Catecholaminehttp://en.wikipedia.org/wiki/Norepinephrinehttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Norepinephrinehttp://en.wikipedia.org/wiki/Catecholaminehttp://en.wikipedia.org/wiki/G_protein-coupled_receptor


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Reseptor adrenergik

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CLONIDIN

entrally acting selecti+e partail 2 adrenergic

agonist Clinical uses :

Antihypertensive drug by virtue f its ability to decrease

SNS output from the CNS ( 0,20,! mg daily p"o #Anaesthetic ad$uvant in spinal or epidural anesthesia

1 mcgkg

%ive analgesia effect &ithin spinal cord modulate

pain path&ay at dorsal horn such as ma$or site fortransmission and modulation pain ( by mimic'ing

activation pf descending Noradrenergi' path&ay and

inhibiting release of substance #


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/reanesthetic medication ( 0 mcgkg p.o #lunt

refle tachycardi ) a,decrease intraoperati+e

la#ility /-R, decrease plasma cathecolamine

concentartion )

/rolong the effect of RA ( 20-103 mcg )

/rotection against perioperati+e myocardischemia ( 3,% mg p.o or transder,al patch )

iagnosis of pheocromocytomareflect a#ility

clonidin to suppress the endogenous release of

cathecolamine #ut not diffusion of ecess

catecholamine into circulation from a

pheocromocytoma ( 3,4 mg p.o )



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Treatment of opioid and alcohol withdrawl syndr

Treatment shi+ering ( 20 mcg "! )

/erioperati+e myocardial ischemia

5ide effect 6

5edation and erostomia

Re#ound y7ertension 8 hr - 49 hr after last dose

( : 1,% mg daily )



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Muscle Relaxan


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83 0-13 13


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Reseptor Adrenergik

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