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Solid Dosage

Protech Solutions Professional Solutions for the Pharmaceutical Industry

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Solid Dosage

Solid Dosage Solutions + Granulating & Drying

Tableting & Encapsulation

Blending

Coating Automatic and Semiautomatic Washing

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Solid Dosage

Content

Conical Mill 4

Bin Blender 5

High Shear Mixer 6

Fluid Bed Drier 8

Capsule Filler (Dosator System) 10

Capsule Filler (Tampering System) 12

Tablet Press 14

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Conical Mill Size Homogenizer

The Conical Mill is equipment used to reduce the size of material in a uniform manner.

It operates by feeding the product into the mill by gravity or vacuum. A rotating impeller forces

the material outward to a conical screen surface, where it is sized and passed through the

opening in the screen. Once finished the product drops through the milling chamber to a

receptor underneath.

The impeller and screens can be customized as per each need.

The Conical Mill can be used not only to reduce the size of particles, but also for de-

agglomeration, sieving, dispersion, and mixing.

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Model 150 300 450 700 1000 Grinding Capacity (kg)

50~150 30 ~300 45~450 70~700 100~1000

Granulity (mesh/in)

6~80

Speed Regulation (rpm)

300~3600

Power (kW) 1.5 1.5 2.2 3 5.5 Dimensions (L x W x H) (mm)

720 x 445 x1345 810 x 445 x1345 920 x 445 x 1430 1000 x 500 x 1530 1000 x 600 x 1875

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Bin Blender Material Mixing

The Bin Blender equipment is ideal for mixing and homogenization of powder and granules. Its

high mixing efficiency and easy use makes it perfect equipment for the Pharmaceutical Solid

Dosage processes.

This equipment has the advantage to be able to be used with any size of Bin giving high flexibility

to be used with different size of batches.

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Model YHA-1

Mixing (rpm) 8~12

Loading Coefficient (%) 50~80

Maximum Net Load (kg) 350

Lifting Speed (mm/min) 750

Size of Drums 300L ~ 400L ~ 600L ~ 800L

Dimensions (L x W x H) 2400 x 1100 x 2480

Working Area (L x W x H) 2400 x 2300 x 2680

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High Shear Mixer HLSG Granulation

With authorized representation and special cooperation with SMA we are bringing the HLSG High Shear Mixer Granulator. This equipment is designed for dry mixing of powders and wet granulation. Mixing and agglomeration of powder particles are achieved by the combined action of the impeller and chopper and liquid binder distribution system. It is supplied in a “through the wall” design and by placing all the auxiliary equipment in the technical area optimized the space in the production area.

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Impeller

With a unique design including three blades with a small wing o each tip to obtain the optimum shear for granulation at every speed. Also includes scrappers at the bottom of each blade to avoid product sticking and maximize product yield

Chopper

This part of the equipment is located on the side of the wall of the bowl with a horizontal shaft that runs at variable speed, counter directional to the impeller to prevent lumps forming. This part controls the granule growth to achieve regular size distribution

Product Bowl and Discharge Valve

The product bowl is designed with no dead zones for mixing and cleaning. It has a wide curvature radius on the bottom to prevent sticking product. The discharge valve is located on the bottom of the side wall to facilitate the discharge operation.

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Solid Dosage High Shear Mixer Granulator +

TECHNICAL AREA

PROCESS AREA

1 Loading of raw material 2 Impeller 3 Chopper 4 Binder Spray System 5 Peristaltic Pump 6 In Line Mill * 7 Discharge valve 8 Sight Glass and Light

* The High Shear Mixer can be integrated with in line Mill for wet granule sizing and direct transfer in a closed system to a fluid bed drier.

WIP –WASH IN PLACE

The WIP is carried out by introducing compressed air from the impeller and chopper seals into the bowl; then running both impeller and chopper at high speed. Washing heads are strategically located to wash difficult to clean zones when the advanced washing kit is provided.

MODEL 60 120 300 600 900 1200 1500 A (mm) 1380 1720 2180 2430 2620 2750 2850 B (mm) 1520 1620 2000 2400 2650 2700 2830 C (mm) 870 1060 1240 1300 D (mm) 850 1050 1315 1500 1700 1800 1900 E (mm) 2120 2220 2600 3070 3320 3370 3490

Bowl Capacity (litters)

60 120 300 600 900 1200 1500

Power (kW) 4 11 18.5 30 45 55 75 Impeller Speed

(rpm) 15~275 15~220 10~165 10~130 10~115 10~1000 10~97

Chopper Speed (rpm)

700~1450 (up to 2000 with frequency inverter

Weight (kg) 500 750 2000 2800 4200 5200 5500

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Fluid Bed Drier Drying – Granulation - Coating

With authorized representation and special cooperation with SMA we are bringing the LGL Modular Fluid Bed Processing Equipment. The LGL is a very flexible fluid bed processing machine with can be set up to accept different product bowls, depending on the product formulation and type of application. The change from one insert to another can be done without tools and is therefore very quick and easy.

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PLANT DIAGRAM 1. PRE HEATING SECTION 2. PRE –FILTER 3. DEHUMIDIFYING SECTION 4. DROP SEPARATOR 5. HEATER 6. HEPA FILTER 7. HEPA FILTER 8. FRE-FILTER 9. PRODUCT FILTERS 10. SILENCER D. DIFFERENTIAL PRESSURE GAUGE P. POWDERTRIBO ELECTRI PROBE

TOP SPRAY

APLICATIONS

• Drying

• Agglomeration

• Granulation

• Granulation

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Solid Dosage Fluid Bed Drier

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SPRAYING SYSTEM

The patented spraying system operates by of a binary nozzle avoiding dripping.

Pressure, volume or weight of spraying solution can be controlled by PLCS.

SAFETY

Quick Action Safety Valves are installed on inlet and outlet air ducts, to contain internal pressures that exceed the pre-set value.

LGL Standard installation is designed to withstand and overpressure up to 3 bar. Installation up to 12 bar, ATEX compliant, are also available.

CHAMBER ROTATION AND FILTERS

The granulation chamber can be lowered and rotated controlled by a PLC.

Filter change and positioning are carried out from the external part of the machine without any needs of lifts or platforms letting the operator do all the operation at floor level.

CLEAN IN PLACE

The machine is fitted with high flow Clean in Place system to optimize cleaning

times and water consumption. All cleaning cycles can be edited and recorded

and thereafter can be easily recalled and reproduced. A printout of washing

parameters can be printed.

LGL KG 1 4 20 35 100 150 200 240 370 440 Container

volume (l) 6 18 66 116 320 480 668 770 1,173 1,400

Fan Unit

Air flow rate (m3/h)

450 900 1,100 1,800 4,000 6,000 8,000 10,000 13,000

Diff. pressure (mbar)

40 90 95

Power (kW) 2 9 15 19 22 30 37 55 75 Utilities Required

Heating Capacity (kW)

7 30 34 61 135 202 269 337 438

Steam Cons. (kg/h)

N.A. 50 60 118 230 354 427 575 748

Comp. Air Cons. (nl/min)

220 450 850 900 1,600 2,100 2,500 220 450 850

Comp. Air Press. (nl/min)

6 6

Spray Nozzle ports (n)

3 4

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Encapsulation (Z-Series) Powder – Pellet – Tablet (Dosator)

The Z-Series capsule-filling machine, with Italian legacy, is reliable equipment that with flexibility will help the pharmaceutical process. The entire capsule-filling cycle entails a unilateral vertical movement that ensures the accuracy dosing patented design. The starting position of the piston inside the dosator can be adjusted separately. The Z-Series offer the maximum versatility of combined filling. Except standard dosing combination, according to the request, customized dosing combination is available.

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Model Z25 Z40 Z85 Z120 Z180 Maximum output (units/h)

25,000 40,000 85,000 120,000 180,000

Number of Capsules per cycle

4 6 11 19 30

Capsule Sizes 000~5 Supports A~E, D~B, DBAA

5~0L 5~0L 00~5

Maximum installed power (kW)

10 14

Standard Voltage (V) 230~440V, 50~60Hz Aspiration 3,850 L/Min, 2,500 mm H2O 5,100 L/Min, 3,200 mm H2O Compressed Air (L/Min)

50@ 60bar 100 @ 6bar

Vacuum 100~20mbar Weight (kg) 1,000 1,400 2,300 Closed size: (L x W x H mm)

960x1216x1800 960x1279x1928 1400x1396x1900

Open size: (L x W x H mm)

2650x2650x1800 2650x2650x1928 3120x3120x1900

Solid Dosage ACCURACY DOSING

Through parameter adjustment and special dosing unit, Z series capsule filler machine can realize the best combination result in production speed and accuracy dosing.

FUNCTIONAL OPTIMIZATION SIMPLE HANDLING Fast and easy size change over, quick and easy clean operation, each specified component equipped with the same dimension square head bolt, only one special tool needed to do adjustments.

RELIABILITY AND COMPACT DESIGN Minimum area need thanks to its compact size, built in electrical cabinet.

CLEAN WORKING COUNTER Z Series capsule filling machine adopt special dosator system which can effectively avoid powder spill phenomenon to ensure a clean working environment.

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Encapsulation Powder – Pellet (Tampering)

This equipment is designed considering the needs of encapsulation needs of pharmaceutical solid dosage processes. The powder is feed by gravity or vacuum to the hopper and is feed by a feeding disk to the open capsules and placed by tampering pins. The machine has an automatic switch-over and control the capsule blanking and avoiding the manual operation. It is equipped with needle brushed blowing to avoid the leakage of product during operation.

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Model NJP500 NJP800 NJP1200 No. of orifices 4 6 9 Max. output (capsules/hour)

30,000 48,000 72,000

Vacuum 27m3/h (-0.02~0.08MPa) Capsule number 00 ~ 5 Filling Accuracy ≥ 99.9% Power (kW) 3 Voltage 380 – 440, 50 -60Hz Dimensions (mm) 800 x 750 x 1950 Weight (kg) 850

Model NJP2200 NJP3200 No. of die orifice 19 23

Max output (capsules/hour)

132,000 192,000

Vacuum 110m3/h (-0.08~0.04MPa) Capsule number 00 ~ 5 Filling Accuracy ≥ 99.9% Power (kW) 10 Voltage 380 – 440, 50 -60Hz Dimensions (mm) 1200 x 1070 x 2100 1420 x 1180 x 2150

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Tablet Press S-Series

The S-Series Tablet Press is reliable, accurate flexible equipment. Is controlled by the newest computer system that can be completely operated by remote. The machine has a compact design. For small series the electrical cabinet is built in the machine maximizing the production area. For the bigger series the electrical cabinet is separated from the machine but with a designed considered to be able to be moved during production as is needed.

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CHAMBER ROTATION AND FILTERS

The upper machine head can be lifted to ease turret removal. This operation is carried out in a short time; the turret can be removed simply and quickly. Afterwards it can be swung out and positioned on a trolley.

High Sealing

Double output chute designs with higher sealing class, which can prevent the spill of the powder; automatic sampling function can realize sampling in process under the closed system.

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Solid Dosage

Number of Stations 44 40 32 26 Tool type * EU-B/IPT-B EU-D/IPT-D Die BBS BB B D Maximum tablet diameter (mm) 11 13 16 25 Maximum output (tablets/hour) 300,000 270,000 220,000 175,000 Maximum die filling (mm) 16 20 Maximum compresion force (kN)

80** 100**

Power (kW) 8 Standard Voltage 400 V (+/-10%) – 50/60 Hz Compressed Air 100 L/Min @ 0.6-0.8 MPa Weight (kg) 1,950 Closed size (L x W x H) (mm) 1320 x 1020 x 1999 Open size (L x W x H) (mm) 2198 x 2124 x 2308

Number of Stations 73 67 55 45 Tool type * EU-B/IPT-B EU-D/IPT-D Maximum tablet diameter (mm) 11 13 16 25 Maximum output (tablets/hour) 700,000 643,200 528,000 432,000 Maximum die filling (mm) 16 20 Maximum compresion force (kN)

100 100 (120 optional)

Power (kW) 15 Standard Voltage 400 V (+/-10%) – 50/60 Hz Compressed Air 100 L/Min @ 0.6-0.8 MPa Weight (kg) 3,500 Closed size (L x W x H) (mm) 1,426 x 1,326 x 2,148 Open size (L x W x H) (mm) 2798 x 2893 x 2248 Maximum Tablet thickness (mm) 8.5 * Special tools/formats available on request ; * Maximum punch load depending on tablet design.

S500

S500 Tablet Press The S500 series equipment has the peculiarity that is able to be connected to an office computer and allow get access to the production information, copying and printing batch production information. The control system is in complete compliance with FDA and cGMP guidelines following the 21CFR part 11 for electrical signature and electrical recording function.

sales@protech-group.com

www.protech-group.com Protech Solutions (Hong Kong) Add:7/F Kin On Comm. BLDG 49 Jervois, St. Sheung Wan, Hong Kong. Phone / Fax + 8621 5499 3845

Protech Solutions –Zhongla- (Shanghai)

Add: Office 301, Building 2, Lane 2328 Chun Shen Road, Minhang District, Shanghai C.P. 201100 Phone: + 86 (21) 5499 3845 / 5499 4837

Protech Technologies (Mumbai)

Add: Crystal Plaza, B/616, Opp. Infinity Mall, New Link Road Andheri West, Mumbai - 400053.