Poster’PrintSize: ’ … · 2015. 11. 3. ·...
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Novel arterial sCffness index was associated with pulmonary funcCon Masaki Okamoto, MD, MPH 1 ; Fumiaki Nakamura, MD, PhD 1 ; Yasuki Kobayashi, MD, PhD 1 ; Terunaga Musha, MD, PhD 2 1 The University of Tokyo, 2 Hachinohe West Health Medical Plaza Masaki Okamoto, MD, MPH Department of Public Health, Graduate School of Medicine, The University of Tokyo 731 Hongo, Bunkyoku, Tokyo 1130033, Japan [email protected] Contact 1. Hisashi Masugata, Shoichi Senda, Hiroki Okada, et al. AssociaAon between arterial sAffness and pulmonary funcAon in hypertensive paAents. Hypertension Research 2012; 35: 388392. 2. Julian G. Ayer, Elena G. Belousova, Jason A. Harmer, et al. Lung funcAon is associated with arterial sAffness in children. PLoS ONE 2011; 6: e26303. 3. Hidehiko Komine, Yoshiyuki Asai, Takashi Yokoi, et al. Noninvasive assessment of arterial sAffness using oscillometric blood pressure measurement. BioMedical Engineering OnLine 2012, 11: 6 doi: 10.1186/1475925x116. References In total, 777 men and 530 women participated in this study. The mean age of total participants was 44.9 years (SD = 5.9), and the percentage of current smokers was 32.0 % (418 out of 1,307). The mean AVI was 15.6 (SD = 4.9), and the mean FEV1 was 3.13 L (SD = 0.65). AVI was negatively correlated with FEV1 (r = −0.21, p < 0.001). In fully-adjusted models, AVI was independently associated with FEV1 (β = −0.03, p = 0.017, 95 % CI = −0.06 to −0.01). IntroducCon We conducted a cross-sectional survey of healthy adults aged 20 years or older at a single large medical center in Hachinohe, Japan between April 2014 and March 2015. We measured AVI using cuff oscillometry. AVI means the characteristics of pulse waves at higher cuff pressure than systolic BP. The outcome measure was forced expiratory volume in one second (FEV1), which was measured with spirometry. We used log-transformed values of AVI and FEV1, as the distributions of these values were skewed. We calculated a correlation coefficient between AVI and FEV1, and performed multiple linear regression analyses to adjust for effects of age, sex, height, and smoking status. Methods Our study showed that an increase of arterial stiffness as assessed via AVI was independently associated with a decrease in FEV1 in the healthy Japanese population. Further study is warranted to confirm these findings in cohort studies. Conclusions Recent studies have shown that the results of vascular function tests, such as pulse wave velocity, augmentation index, or cardio-ankle vascular index (CAVI), were associated with pulmonary function in children or hypertensive patients, and increased CAVI might be correlated with progression of chronic obstructive pulmonary disease. 1.2. However, the association between vascular function and pulmonary function remains unclear, especially in healthy adult people. Arterial velocity pulse index (AVI) is a novel arterial stiffness index that can be measured more easily than previous methods. 3. The aim of this study was to investigate the association between AVI and pulmonary function test results in the healthy adult population. Results Table 1. Baseline characteristics of participants No. of parAcipants 1307 Male 777 [59.4] Age (years) 44.9 ± 5.9 Height (cm) 166.1 ± 8.2 Current smoker 418 [32.0] AVI 15.6 ± 4.9 FEV1 (L) 3.1 ± 0.7 Coef. P value 95% C.I. Log ( AVI ) 0.033 0.017 0.061, 0.006 Male 0.211 < 0.001 0.190, 0.232 Age 44 ( reference ) 45 54 55 64 65 0.044 0.185 0.191 < 0.001 < 0.001 < 0.001 0.059, 0.029 0.219, 0.152 0.246, 0.135 Height 159 ( reference ) 160 169 170 179 180 0.101 0.178 0.288 < 0.001 < 0.001 < 0.001 0.080, 0.122 0.151, 0.205 0.246, 0.329 Current smoker 0.027 0.001 0.043, 0.012 Data are means±SD or n [%]. P138 Table 2. CorrelaAons coefficients of log(FEV1) in multiple linear regression analyses Figure. Correlation between AVI and FEV1 The authors have declared that no competing interests exist. CompeCng Interests Adjusted Rsquared = 0.64
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Novel arterial sCffness index was associated with pulmonary funcCon Masaki Okamoto, MD, MPH1; Fumiaki Nakamura, MD, PhD1; Yasuki Kobayashi, MD, PhD1; Terunaga Musha, MD, PhD2
1The University of Tokyo, 2Hachinohe West Health Medical Plaza
Masaki Okamoto, MD, MPH Department of Public Health, Graduate School of Medicine, The University of Tokyo 7-‐3-‐1 Hongo, Bunkyo-‐ku, Tokyo 113-‐0033, Japan [email protected]‐tokyo.ac.jp
Contact 1. Hisashi Masugata, Shoichi Senda, Hiroki Okada, et al. AssociaAon between arterial sAffness and pulmonary funcAon in hypertensive paAents.
Hypertension Research 2012; 35: 388-‐392. 2. Julian G. Ayer, Elena G. Belousova, Jason A. Harmer, et al. Lung funcAon is associated with arterial sAffness in children. PLoS ONE 2011; 6: e26303. 3. Hidehiko Komine, Yoshiyuki Asai, Takashi Yokoi, et al. Non-‐invasive assessment of arterial sAffness using oscillometric blood pressure measurement.
BioMedical Engineering OnLine 2012, 11: 6 doi: 10.1186/1475-‐925x-‐11-‐6.
References
In total, 777 men and 530 women participated in this study. The mean age of total participants was 44.9 years (SD = 5.9), and the percentage of current smokers was 32.0 % (418 out of 1,307). The mean AVI was 15.6 (SD = 4.9), and the mean FEV1 was 3.13 L (SD = 0.65). AVI was negatively correlated with FEV1 (r = −0.21, p < 0.001). In fully-adjusted models, AVI was independently associated with FEV1 (β = −0.03, p = 0.017, 95 % CI = −0.06 to −0.01).
IntroducCon
We conducted a cross-sectional survey of healthy adults aged 20 years or older at a single large medical center in Hachinohe, Japan between April 2014 and March 2015. We measured AVI using cuff oscillometry. AVI means the characteristics of pulse waves at higher cuff pressure than systolic BP. The outcome measure was forced expiratory volume in one second (FEV1), which was measured with spirometry. We used log-transformed values of AVI and FEV1, as the distributions of these values were skewed. We calculated a correlation coefficient between AVI and FEV1, and performed multiple linear regression analyses to adjust for effects of age, sex, height, and smoking status.
Methods
Our study showed that an increase of arterial stiffness as assessed via AVI was independently associated with a decrease in FEV1 in the healthy Japanese population. Further study is warranted to confirm these findings in cohort studies.
Conclusions
Recent studies have shown that the results of vascular function tests, such as pulse wave velocity, augmentation index, or cardio-ankle vascular index (CAVI), were associated with pulmonary function in children or hypertensive patients, and increased CAVI might be correlated with progression of chronic obstructive pulmonary disease. 1.2.
However, the association between vascular function and pulmonary function remains unclear, especially in healthy adult people. Arterial velocity pulse index (AVI) is a novel arterial stiffness index that can be measured more easily than previous methods. 3.
The aim of this study was to investigate the association between AVI and pulmonary function test results in the healthy adult population.
Results
Table 1. Baseline characteristics of participants
No. of parAcipants 1307 Male 777 [59.4] Age (years) 44.9 ± 5.9 Height (cm) 166.1 ± 8.2 Current smoker 418 [32.0] AVI 15.6 ± 4.9 FEV1 (L) 3.1 ± 0.7
Coef. P value 95% C.I.
Log ( AVI ) -‐0.033 0.017 -‐0.061, -‐0.006
Male 0.211 < 0.001 0.190, 0.232
Age -‐ 44 ( reference ) 45 -‐ 54 55 -‐ 64 65 -‐
-‐
-‐0.044 -‐0.185 -‐0.191
-‐
< 0.001 < 0.001 < 0.001
-‐
-‐0.059, -‐0.029 -‐0.219, -‐0.152 -‐0.246, -‐0.135
Height -‐ 159 ( reference ) 160 -‐ 169 170 -‐ 179 180 -‐
-‐
0.101 0.178 0.288
-‐
< 0.001 < 0.001 < 0.001
-‐
0.080, 0.122 0.151, 0.205 0.246, 0.329
Current smoker -‐0.027 0.001 -‐0.043, -‐0.012 Data are means±SD or n [%].
P138
Table 2. CorrelaAons coefficients of log(FEV1) in multiple linear regression analyses
Figure. Correlation between AVI and FEV1
The authors have declared that no competing interests exist. CompeCng Interests
Adjusted R-‐squared = 0.64
