NeuroRegeneration Conference Public

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Hope For The Healing BrainRestoring Your Brains Chemical Communication

Jeremy E. Kaslow, M.D.Santa Ana, California

www.drkaslow.comJanuary 21, 2012

THE ACADEMY OF

COMPREHENSIVE INTEGRATIVE MEDICINE


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Root Causes of Disease

Only by understanding the wisdom ofthe body shall we attain that mastery

of disease and pain which shall enableus to relieve the burden of mankind.

William Harvey, M.D.

January 2012 Jeremy E. Kaslow, MD 3


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Root Causes of Disease

Genetics

Toxicity

Psychological/Emotional Imprints

Infections*

Structure Nutrition



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PATHWAYS

Metabolic

Neuromuscular

Immunologic

Infections*

Inflammation

Endocrine

Psychological

ROOT CAUSES

Genetics

Toxicity

Psychoemotional

Infections*Structure

Nutrition

NeuroDegeneration


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Avoidance

StructureDetoxification

Nutrition



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Brain Health vs. Brain Aging

Primary regulator of overall health is brain /CNS

health. Your body cannot function optimally if

the master controller, your brain is not

functioning optimally.

Brain /CNS health depends on:

1. The number and function of CNS cells (100 billion

neurons and 1000 billions glial cells)2. Neurotransmitter balance to deliver signals between

neurons in the brain, nervous system and other cells.


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Brain /CNS Cellular Health

Hallmarks of neurodegeneration:1. Mitochondrial dysfunction

2. Oxidative Stress

3. Neuroinflammation Several PPAR agonists are possible therapeutic

agents for neurodegenerative disorders becausethey have been shown to protect against:1. Mitochondrial dysfunction

2. Oxidative damage

3. Inflammation

4. Apoptosis (programmed cell death)


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Peroxisome Proliferator-Activated Receptors

(PPARS)

PPARS are factors that bind directly to DNA andregulate gene expression

Initially, it was thought that PPARs activity was

limited to lipid metabolism and glucosehomeostasis, but PPAR- is also expressed inbrain neurons and astrocytes

Several studies demonstrated PPAR- agonists

improve disease-related symptoms andpathology in animals by directly improvingmitochondrial function and ATP production


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PPARS ligands

Fatty acids and their derivatives are the main

natural ligands of all PPARs: palmitic, oleic,

linolenic, linoleic, and arachidonic acid

Synthetic ligands include the glitazones,

tyrosine-based agonists, and non-steroidal

anti-inflammatory drugs (fenoprofen,

ibuprofen, and indomethacin), and fibrates


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PPARS agonists/activators

Soy isoflavones genistein, daidzein, biochanin A,formononetin, and glycitein

Red Clover metabolites equol, ODMA, 6-hydroxydaidzein,3-hydroxygenistein, 6-hydroxy-ODMA, dihydrogenistein,

and dihydrodaidzein Turmeric (curcumin)

Cinnamon

Amino Acids (glutamine, arginine)

green tea (catechin, epigallocatechin-3-gallate)

Grape and blueberry phytochemicals (pterostilbene)

Lipoic acid

Acetyl-l-carnitine


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Neurotransmitters


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Multiple Pathways



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Neurotransmitter Associations

Dopamine functions in the brain include roles in:

behavior and cognition

voluntary movement

motivation

punishment and reward

inhibition of prolactin production (involved in lactation and sexual gratification) mood

attention

working memory

learning

Dopamine Insufficiency: Loss of control/addictions/cravings of any type

Obesity

Parkinsons Disease

Restless Leg Syndrome



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Serotonin Insufficiency:

Sleep disorders

Sugar cravings

Eating disorders (bulimia/anorexia)

Sexual Addiction



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Acetylcholine Insufficiency:

Dehydration (Ach controls moisture levels)

Arthritis

Osteoporosis

Multiple Sclerosis



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Memory & Neurotransmitters

Acetylcholine access memory

speed and immediate memory

Dopamine working memory

Serotonin visual memory and perception

GABA organization of memory


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