K. Parasit Oportunistik

8/18/2019 K. Parasit Oportunistik

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Protozoa oportunistik

Dr. Diana Natalia

Departemen Parasitologi, Fakultas kedokteran UniversitasTanjungpura


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CRYPTOPOR!D!U"

PROTO#O$ UU % D!$R& P$D$

'&($N )*+ % D!$R& P$D$ "$NU!$

P&ND&R!T$ !"UNO-O"PRO"$! %

D!$R& &R$T


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CRYPTOPOR!D!U"

'OP& "$"$/!$ % "$NU!$, $P!, DO"$

$!, $N0!N1, -UC!N1,"ONY&T, -&/!NC!, "&NC!T

URUN1 R&PT!/!$ 2 U/$R 3

P&NY$-!T % -R!PTOPOR!D!O!

P&NY&$R$N % -O"OPO/!T


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CRYPTOPOR!D!U"

"ORFO/O1! D$N D$UR '!DUP P&!& P$D$ "$NU!$ %

CRYPTOSPORIDIUM PARVUM COCC!D!$, "!R!P !OPOR$ D$N

TO4OP/$"$

C$R$ !NF&-! % T&RT&/$NOO-!T$

"$T$N1


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Oocyst (infective stage)


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CRYPTOPOR!D!U"

"ORFO/O1! D$N D$UR '!DUP &--!T$! D! UU -&C!/

SPOROZOIT : MASUK SEL EPITELUSUS, D! /U$R !TOP/$"$ %

D!&UT "&RONT

MEROGONI GAMETOGONI SPOROGONI


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CRYPTOPOR!D!U"

"ORFO/O1! D$N D$UR '!DUP MERONT : 4 - 5 MIKRON

OOKISTA : 4 - 5 MIKRON OOKISTA 2 MACAM :D!ND!N1 T!P! % $UTO!NF&-!

D!ND!N1 T&$/ % -&/U$R D&N1$N T!N0$ "$$ PR$P$T&N % 5 6 7) '$R! P&N1&/U$R$N OO-!T$ %

IMUNOKOMPETEN : SEBULAN

IMUNOKOMPROMAIS : SEBULAN ±

>


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CRYPTOPOR!D!U"

P$TO/O1!'$!T$T %

&/URU' TR$-TU D!1&T!8U,

T&RUT$"$ Y&YUNU" -$NDUN1 &"P&DU $/UR$N P$N-R&$

P&"&R!-$$N '!TO/O1!- $TROF! 8!/U

-R!PT$ /$"!N$ PROPR!$ % !NF!/TR$! &/ "ONONU-/&$R P$R$!T P$D$ P&R"U-$$N &/ &P!T&/

>


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CRYPTOPOR!D!U"

1&0$/$ -/!N! '&($N %

DIARE AKUT ANOREKSIA BERAT BADAN TURUN SEMBUH SENDIRI ATAU MATI

"$NU!$ % T&R1$NTUN1 T$TU!"UN


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CRYPTOPOR!D!U"

1&0$/$ -/!N! !"UNO-O"P&T&N %

$!"TO"$T!- 9&/F /!"!T&D: 2D!$R& ) U/$N 3

!"UNO-O"PRO"$! %

D!$R& "&N$'UN "$T! D!$R& % T!N0$ C$!R, &R! N&1$T!F

2 ; U/$N 6 < T$'UN 3 -&'!/$N1$N C$!R$N < 6 )+ /!T&R 2D&'!DR$! 3 NY&R! U/U '$T!, "U$/, "UNT$', $NOR&-!$ D&"$" R!N1$N "$T! -$R&N$ D!$R& = "$/NUTR!!


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CRYPTOPOR!D!U"

D!$1NO! "&N&"U-$N OO-!T$ D$/$" T!N0$

C$R$ /$N1UN1 : OO-!T$

. -&C!/ 2;65"!-RON3

. "!R!P &/ R$1!

PU/$$N #!&'/ 6 N&&/&N %

. OO-!T$ U/$T "&R$'

. &/ R$1! /ON0ON1 !RU

C$R$ -ON&NTR$! 2 F/OT$! 3 &RO/O1! % &/!$, !F$


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CRYPTOPOR!D!U"

P&N1O$T$N $NT!!OT!-$ = -&"OT&R$P&UT!-$ %

T!D$- "&NO/ON1

'&NT!-$N T&R$P! !"UNOUPR&!F

P!R$"!!N < 4 ) 1R$" = &'$R!, 7"1, D$P$T "&NO/ON1


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CRYPTOPOR!D!U"

&P!D&"!O/O1! P&NY&$R$N -O"OPO/!T

PR&8$/&N! % !D$'O % $N$- $P! ;;,; > $UTR$/!$ % P$!&N D!$R& ;,)> 0$-$RT$ % $N$- D!$R& ),

D&($$ D!$R& ?,5>

U"&R !NF&-! % '&($N = "$NU!$

:TR$8&//&R@ D!$RR'&$:

9 D$Y C$R& C&NTR& :

&P!D&"! "&/$/U! $!R "!NU"

OO-!T$ "$T! P$D$ 5 C°


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CYC/OPOR$ C$Y&T$N&N!

HOSPES: MANUSIA

HEWAN ?

PENYEBARAN : KOSMOPOLIT

BANYAK DI NEGERI SEDANGBERKEMBANG


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"ORFO/O1! D$N D$UR '!DUP P&!& COCC!D!$

P$R$!T !NTR$!TOP/$"!- D$/$" Y&Y&NU" OO-!T$ !"$TUR D$/$" T!N0$

PORU/$! % ) 6 &&R$P$ "!N11U OO-!T$ "$T$N1 % 7 PORO-!T$

"$!N16"$!N1 7 PORO#O!T OO-!T$ % A6)? "!-RON

C$R$ !NF&-! % T&RT&/$N OO-!T$ "$T$N1


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Oocyts Oocyts


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P$TO/O1! D$N 1&0$/$ -/!N! "$$ !N-U$! ) "!N11U

D!$R& D&N1$N T!N0$ C$!R $NOR&-!$, TURUN, -&"UN1, NY&R!

U/U '$T!, "UNT$', NY&R! OTOT, D&"$"R!N1$N, R$$ C$P$!

T$NP$ P&N1O$T$N % &&R$P$ '$R!$"P$! &U/$N $T$U B, &R!N1 -$"U'

-$D$N16-$D$N1 $!"TO"$T!-

±


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D!$1NO! "&N&"U-$N OO-!T$ D$/$" T!N0$

CARA LANGSUNG CARA KONSENTRASI MIKROSKOP FLUORESEN ULTRAVIOLET

PU/$$N T$'$N $$" % OO-!T$ "&R$'"UD$6TU$


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P&N1O$T$N % D&($$ % TR!"&TOPR!" )? "1

U/F$"&TO-$#O/ A?? "1 74

&'$R!, + '$R!

$N$- % TR!"&TOPR!" 5 "1=-1 U/F$"&TO-$#O/ 75 "1=-1

7 4 &'$R!, + '$R! $!D % DO! B T!N11!

P&N1O$T$N 9"$!NT&N$NC&:


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&P!D&"!O/O1! TRAVELLER!S DIARRHEA" INFEKSI PADA :

SEMUA UMUR IMUNOKOMPETEN

IMUNOKOMPROMAIS #$%$ : KASUS PERTAMA

MINUM AIR TIDAK DIMASAK


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&P!D&"!O/O1! AMERIKA&CANADA

#$$' : DIARE PADA #5( ORANGSUMBER INFEKSI DIDUGA STRAWBERRY

#$$' : DIARE PADA #((( ORANG

SUMBER INFEKSI DIDUGA RASPBERRY

#$$% : % EPIDEMI DI CALIFORNIA FLORIDA,

NEW YORK, TE)AS, NEVADA

PENCEGAHAN : MENGHINDARI MAKANAN&MINUMAN

TERCEMAR TIN*A


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ISOSPORA BELLI

HOSPES DEFINITIF : MANUSIA

PENYEBARAN LUAS : AMERIKA

TENGAH&SELATAN, AFRIKA, ASIA TENGGARA

PENYAKIT : INFEKSI OPORTUNISTIK

PADA AIDS


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ISOSPORA BELLI

"ORFO/O1!

OOKISTA BU*UR MEMAN*ANG 25 - ++ MIKRON ) #2 - #' MIKRON

DINDING BERLAPIS DUA, RATA,

TANPA WARNA

SITOPLASMA BERGRANULA

SATU INTI


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ISOSPORA BELLI

SATU HOSPES

CARA INFEKSI MENELAN OOKISTA

MATANG DARI TANGAN KE MULUT

DENGAN MAKANAN DAN AIR YANG

TERKONTAMINASI OOKISTA


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ISOSPORA BELLI

1&0$/$ -/!N! TANPA GE*ALA

DIARE, DEMAM, SAKIT PERUT

SINDROM MALABSORPSI

FATAL


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ISOSPORA BELLI

P$TO/O1! VILUS PENDEK

KRIPTA HIPERTROFIS

INFILTRASI SEL DI LAMINA PROPRIA

PARASIT INTRASELULAR DALAMSEL EPITEL


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ISOSPORA BELLI

D!$1NO! MENEMUKAN OOKISTA DALAM TIN*A


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ISOSPORA BELLI

P&N1O$T$N INFEKSI ASIMTOMATIK ATAU RINGAN

: TIDAK PERLU PENGOBATAN INFEKSI AKUT ATAU BERAT :

P!R!"&T$"!N U/F$D!$#!N

TR!"&TOPR!" U/F$"&TO-$#O/

AIDS : DILAN*UTKAN DENGAN DOSISRENDAH


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"!CROPOR!D!$

PHYLLUM :

- MYCOSPORA

- 100 !"US

- 1000 SP!S#!S

"AMA P!"YA$#% : M#$ROSPOR#OS#S

S%R#'US# !ORA#$ : $OSMOPOL#%


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"ORFO/O1! D$N D$UR '!DUP

SPORA '!R'!"%U$ :

- S!R#S

- OAL

- M!MA"*A"

U$URA" : 1 + ,0 M#$RO"

Enterocytozoon : 1. / 0.µ

Encephalitozoon : ei2s ,. / 1. µ

Nosema : ova 3 4 , µ

Pleitophora : ova ,5 4 63 µ7


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http://jcm.asm.org/content/vol40/issue6/images/large/jm0620113001.jpeg


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'OP&

Hos2es %e02at infe8si

Enterocytozoon bieneusi 0an9sia- :a:i- 2;i0ata e2it


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P$TO/O1! D$N 1&0$/$ -/!N!

Hos2es i9no8o2eten : - s98inis- 8;onis

Hos2es i9no8o2;oais : 8eatian

O;gan yang te;iat :

- intestina - gina

- ota8 - otot

- ant9ng - ata

-


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P$TO/O1! D$N 1&0$/$ -/!N!

#nfe8si intestina :

- f;e89ensi tina 1 + ,0 8ai?


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P$TO/O1! D$N 1&0$/$ -/!N!

E. bieneusi

- ei< se;ing 2a=a 2asien A#&S

- te;9taa ente;osit 9s9s


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P$TO/O1! D$N 1&0$/$ -/!N!

Encephalitozoon spp

- 9s9s


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P$TO/O1! D$N 1&0$/$ -/!N!

Pleistophora

- 2a=a 2asien i9no8o2;oais : iositis

Mic;os2o;i=ia 2a=a ata :

- co;nea st;oa 8e;atitis

- e2it


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K./0103/6/7- i9no8o2eten : - Encephalitozoon ti=a8 e9as

s2 8e e2it


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D.8077- i8;os8o2i8 2a;asit : - i8;os8o2 ca


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Penilaian semikuantitatif

9a< s2o;a 2e; sa2e tina

0 : ti=a8 a=a s2o;a

1 : s2o;a a;ang

, : ee;a2a s2o;a6 : anya8 s2o;a


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"ikroskop aEaa

- Mo=ifi8asi t;i8;o (ee;-;een o=ifie= t;ic


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"ikroskop aEaa

- PeEa;naan g;a ';oEn ';enn : - s2o;a g;a ()

- 2otongan a;ingan- PeEa;naan 2e;a8 a;t


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PengoGatan

-

Aen=aoD te;9taa gen9s Encephalitozoon

D eng


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PengoGatan- 9agiin

D =osis : E.bieneusi : 6 4 ,0 g?


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&pidemiologiHi=92 =i ai; 2a=a 3oC > 1 ta

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