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GGGNNNIIIPPPSSSTTT BBBUUULLLLLLEEETTTIIINNN 22200011155504th September, 2015 Volume No.: 48 Issue No.: 04

Vision

TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE

BASED LEARNING AND PRACTICE

Contents • Message from PRINCIPAL• Editorial board• Historical article• News Update• Knowledge based Article• Disease Related Breaking

News• Upcoming Events• Drugs Update• Campus News• Student’s Section• Editor’s Note• Archive

GNIPST Photo Gallery For your comments/contribution OR For Back-Issues, mailto:gnipstbulletin@gmail.com

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

W e bs i t e : ht t p: / / gni ps t. a c. i n

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MESSAGE FROM PRINCIPAL

"It can happen. It does happen. But it can't happen if you quit." Lauren Dane.

‘We are what we repeatedly do. Excellence then is not an act, but a habit.’ Aristotle

It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the last year’s editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are supported in maximizing their potential and talents. Education needs to focus on personalized learning and instruction, while promoting an education system that is impartial, universally accessible, and meeting the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to achieve their aims. We are all very proud of you, our students, and your accomplishments and look forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in this direction and fruits of these efforts will be received by our students in the near future. Our Teachers are committed and dedicated for the development of the institution by imparting their knowledge and play the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on this path.

My best wishes to all.

Dr. A. Sengupta

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EDITORIAL BOARD

CHIEF EDITOR DR. ABHIJIT SENGUPTA EDITOR MS. JEENATARA BEGUM ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE

Sarvepalli Radhakrishnan Sarvepalli Radhakrishnan was born on September 5, 1888, at Tiruttani, forty miles to the north-east of Madras, in South India. His early years were spent in Tiruttani and Tirupati, both famous as pilgrim centres. He graduated with a Master's Degree in Arts from Madras University. In partial fulfilment for his M.A. degree, Radhakrishnan wrote a thesis on the ethics of the Vedanta titled "The Ethics of the Vedanta and Its Metaphysical Presuppositions", which was a reply to the charge that the Vedanta system had no room for ethics. Professor A.G. Hogg awarded the following testimonial for this thesis: "The thesis which he prepared in the second year of his study for this degree shows a remarkable understanding of the main aspects of the philosophical problems, a capacity for handling easily a complex argument besides more than the average mastery of good English". The thesis indicates the general trend of Radhakrishnan's thoughts... In his own words, "Religious feeling must establish itself as a rational way of living. If ever the spirit is to be at home in this world, and not merely a prisoner or a fugitive, spiritual foundations must be laid deep and preserved worthily. Religion must express itself in reasonable thought, fruitful action and right social institutions." In April 1909, he was appointed to the Department of Philosophy at the Madras Presidency College. From then on, he was engaged in the serious study of Indian philosophy and religion, and was a teacher of Philosophy.

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In 1918, he was appointed Professor of Philosophy in the University of Mysore. Three years later, he was appointed to the most important philosophy chair in India, King George V Chair of Mental and Moral Science in the University of Calcutta. Radhakrishnan represented University of Calcutta at the Congress of the Universities of the British Empire in June 1926 and the International Congress of Philosophy at the Harvard Univesity in September 1926. At the Philosophical Congress held at Harvard University, the lack of spiritual note in modern civilization was the focus of his address to the general meeting. In 1929, Radhakrishnan was invited to take the post vacated by Principal J. Estin Carpenter in Manchester College, Oxford. This gave him the opportunity to lecture to the students of University of Oxford on Comparative Religion. During that visit, he also gave the Hibbert Lectures on "An Idealist View of Life" to audiences at the Universities of London and Manchester. In his own words, "It was a great experience for me to preach from Christian pulpits in Oxford and Birmingham, in Manchester and Liverpool. It heartened me to know that my addresses were liked by Christian audiences. Referring to my sermon on "Revolution through Suffering", an Oxford daily observed, "Though the Indian preacher had the marvellous power to weave a magic web of thought, imagination and language, the real greatness of his sermon resides in some indefinable spiritual quality which arrests attention, moves the heart and lifts us into an ampler air." From 1936-39, Radhakrishnan was the Spalding Professor of Eastern Religions and Ethics at Oxford University. In 1939, he was elected Fellow of the British Academy. From 1939-48, he was the Vice-Chancellor of the Banaras Hindu University. He later held offices that dealt with India's national and international affairs. He was the leader of the Indian delegation to UNESCO during 1946-52. He was the Ambassador of India to U.S.S.R. during 1949-52. Hewas the Vice-President of India from 1952-1962 and the President, General Conference of UNESCO from 1952-54. He held the office

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of the Chancellor, University of Delhi, from 1953-62. From May 1962 to May 1967, he was the President of India. Aldous Huxley observed that Dr. Radhakrishnan "is the master of words and no words." Prof. H.N. Muirhead said, "Dr. Radhakrishnan has the rare qualification of being equally versed in the great European and the not less great Asiatic tradition which may be said to hold in solution between them the spiritual wisdom of the world, and of thus speaking as a philosophical bilinguist upon it." George P. Conger said, "Among the philosophers of our time, no one has achieved so much in so many fields as has Sarvepalli Radhakrishnan of India ... William James was influential in religion, and John Dewey has been a force in politics. One or two American philosophers have been legislators. Jacques Maritain has been an ambassador. Radhakrishnan, in a little more than thirty years of work, has done all these things and more... Never in the history of philosophy has there been quite such a world-figure. With his unique appointment at Banaras and Oxford, like a weaver's shuttle, he has gone to and fro between the East and West, carrying a thread of understanding, weaving it into the fabric of civilization." Sarvepalli Radhakrishnan passed away on April 17, 1975. In India, September 5 (his birthday) is celebrated as Teacher's Day in his honor.

NEWS UPDATE New medical device concept could reduce time to

diagnose infections: (04th September, 2015) When a patient arrives at a hospital with a serious infection, doctors have precious few minutes to make an accurate diagnosis and prescribe treatment accordingly. A new diagnostic device may significantly reduce the amount of time necessary to diagnose tissue infections.

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Common antidepressant may change brain differently in depressed and non-depressed people: (04th September, 2015) A commonly prescribed antidepressant may alter brain structures in depressed and non-depressed individuals in very different ways.

IV administration of endothelin B receptor drug reduces memory loss, oxidative stress in Alzheimer's disease: (04th September, 2015) An estimated 5.3 million people in the U.S. suffer from Alzheimer’s disease (AD). The five current FDA-approved AD medications only help mask the disease symptoms instead of treating the underlying disease. In a new study, researchers used IRL-1620, a chemical that binds to endothelin B receptors, to treat AD in rats.

Vitamin C: The exercise replacement? : (04th September, 2015) Exercise improves health in overweight and obese adults but can be hard to incorporate into a daily routine. New findings show that taking vitamin C supplements daily instead can have similar cardiovascular benefits as regular exercise in these adults.

Targeting glucose production in liver may lead to new diabetes therapies: (03rd September, 2015) A biological checkpoint known as the Mitochondrial Pyruvate Carrier is critical for controlling glucose production in the liver and could potentially be a new target for drugs to treat diabetes, new research shows.

Manipulation of food structure could lead the way to a healthier diet: (02nd September, 2015) Preserving the natural structure of dietary fiber during food production can help to slow the rise in blood sugar levels after a meal, researchers show. Starch is one of the largest sources of calories and an important component of a healthy diet.

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Understanding how starch is digested and metabolized is highly relevant to weight management, as well as prevention of other related conditions such as type 2 diabetes and heart disease, authors say.

Driving with central visual field loss II: How scotomas affect hazard detection in a driving simulator: (02nd September, 2015) Vision researchers have published the second paper of a study designed to determine if a driver who suffers from loss of central vision is able to detect pedestrians in a timely manner when driving. Central visual field loss, a scotoma or blind area in central vision, is found most commonly in patients with age-related macular degeneration (AMD). Patients with AMD may drive provided their visual acuity at least meets the requirements for a restricted license. However, the size and location of the blind area are usually not considered when making licensing decisions. The purpose of the study was to evaluate how much these blind areas delayed responses to pedestrian hazards in the safe environment of a driving simulator.

Alirocumab dramatically lowers cholesterol in familial hypercholesterolemia patients: (01st September, 2015) Alirocumab lowers cholesterol in patients with heterozygous familial hypercholesterolemia to levels unreachable with statins alone, according to new results. This analysis in more than 1 250 patients showed that alirocumab rapidly lowered low density lipoprotein cholesterol (LDL-C) to unprecedented levels and the reductions were maintained long term. For detail mail to editor

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KNOWLEDGE BASED ARTICLE

Before nature selects, gene networks steer a course for evolution

Natural selection is a race to reproduce, a competition between individuals with varying traits that helps direct the evolution of a species. As scientists begin to explore the complex networks of genes that shape the form and function of each individual, they can ask a new question about evolution: How do the structures of these gene networks determine which individuals appear on the starting line, silently influencing evolution before competition has even begun? University of Illinois researchers Karen Sears and Zoi Rapti, along with collaborators at Illinois and four other institutions, have addressed this question by exploring the gene network that guides limb development in mammals. They found that during early development, when limbs are first forming, gene activity in this network varies little; later, when detailed limb structure is beginning to emerge, the network changes in structure, and gene activity varies more widely. This pattern may make it easier for evolution to tweak, rather than remodel, limb structure. "When we look at the evolutionary record of animals, we find that there are some forms that have evolved repeatedly, and some that have never evolved," Sears said. "I want to know the role that development has in generating these patterns." Sears, an associate professor of animal biology, and Rapti, an associate professor of mathematics, led the study, which was published in PLOS Genetics. Sears is a member of the Carl R. Woese Institute for Genomic Biology (IGB).

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Many genes encode proteins that influence or regulate each other's activity. These functional connections, and the genes that participate in them, can be imagined as the threads and intersections of a spider's web. Some of these interactions are stronger or weaker than others, and in the network they comprise, some genes have more connections than others. Computational models can mathematically describe this network structure. Sears, Rapti, and colleagues wanted to know what happens when a chance event, like a mutation, changes the activity of one gene. How much will the whole network, and the resulting course of development, be affected? Using published data on developmental gene interactions, they created a model of how genes interact during early and late stages of limb development. The model allowed them to pluck at the spider web of genes, and watch how much the rest of the web is disrupted. The researchers found that in early limb development, the network resists the spread of change; even when one gene's activity is altered, the network as a whole continues to function almost as usual. Later in limb development, however, the architecture of the network is different, and a change in one gene's activity has a more widespread impact. In addition, an empirical investigation of gene activity during limb develop in four different mammals--mice, bats, opossums, and pigs--showed that activity of developmental genes differs more in late development than in early development. This is true when comparing individuals of the same species, and also when comparing gene activity across species. Together, these theoretical and empirical findings supported Sears' strongest initial hypothesis, that genomic mechanisms restrict the degree to which early limb development can vary in mammals. From an evolutionary perspective, this makes sense. "If early development is disrupted, limb development will be severely disrupted, and it is very unlikely that the resulting limb structure will be selectively advantageous, said Sears. "Later

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development, which doesn't have as many downstream impacts, might be expected to be more free to vary because the consequences of that variation would be less dire."

Jeenatara Begum Assistant Professor

GNIPST

DISEASE RELATED BREAKING NEWS Circulating vaccine-derived poliovirus – Ukraine:

(01st September, 2015) In Ukraine, 2 cases of circulating vaccine-derived poliovirus type 1 (cVDPV1) have been confirmed, with dates of onset of paralysis on 30 June and 7 July 2015. Both are from the Zakarpatskaya oblast, in south-western Ukraine, bordering Romania, Hungary, Slovakia and Poland. One child was 4 years old and the other 10 months old at the time of onset of paralysis. Ukraine had been at particular risk of emergence of a cVDPV, due to inadequate vaccination coverage. In 2014, only 50% of children were fully immunized against polio and other vaccine-preventable diseases. Read more

UPCOMING EVENTS 3rd International Conference and Exhibition on Pharmacognosy,

Phytochemistry & Natural Products will be held on 26th to 28th October, 2015 at Hydrabad.

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DRUGS UPDATES FDA Approves Expanded Indication for Brilinta to

Include Long-Term Use in Patients with a History of Heart Attack: (03rd September, 2015) AstraZeneca announced that the US Food and Drug Administration (FDA) has approved Brilinta (ticagrelor) tablets at a new 60mg dose to be used in patients with a history of heart attack beyond the first year. With this expanded indication, Brilinta is now approved to reduce the rate of cardiovascular death, myocardial infarction (MI, also known as heart attack) and stroke in patients with acute coronary syndrome (ACS) or a history of MI. Read more

CAMPUS NEWS CARNIVAL OF CANVASS:

On 4th September the Students of GNIPST celebrated the freshers party for masters degree students.

On 4th September the students of GNIPST celebrated Teacher's Day. ESPERANZA:

On 21st August, 2015 the 1st year students of GNIPST were welcomed in the Freshers Welcome Programme ‘ESPERANZA’.

HOMAGE TO FORMER PRESIDENT DR A P J ABDUL KALAM: On 31st July, 2015 all the students and teachers of GNIPST paid their homage for our former president Dr. A P J Abdul Kalam. ALUMNI ASSOCIATION:

GNIPST has been certified by the Alumni Association under the West Bengal Societies Registration Act, 1961.

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FAREWELL PROGRAMME: On 15th May 2015 GNIPST celebrated the farewell programme ‘Sesh Chithi’ for the final year students of M.Pharm, M.Sc, B.Pharm, B.Sc and BHM. JIS SAMMAN 2015

On 11th May, 2015 GNIPST attended the JIS SAMMAN 2015. JIS SAMMAN Awards: • Best College (Non Engineering):

GNIPST• Best Principal:

Dr (Prof.) Avijit Sengupta• Best HOD:

Mr. Jaydip Ray• Best Faculty:

Mr. Debabrata Ghoshdastidar (Pharmacy)Dr. Swati Chakraborty (Life Sciences)

• Best faculty since inception:Mr. Jaydip Ray

• Best Office Staff:Ms. Jaya Banerjee

• Best technical Assistant:Mr. Somnath Majhi

• College Blue:Avik Paul

• Highest DGPA of 2014:B.Pharm:Purbali Chakraborty (4th year)Diksha Kumari (3rd year)Aishika Dutta (2nd year)Sampita Paul (1st year)M.Pharm:Aritra Mukherjee (Pharmaceutical Chemistry)Mounomukhar Bhattacharya (Pharmacology)B.Sc (Biotechnology):

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Papiya Saha (3rd year) Shomasree Das (2nd year) Ayanita Basak (1st year) B.Sc (Microbiology): Bonhisikha Chatterjee (3rd year) Riaz Hossain (2nd year) Soumi Chowdhury (1st year) BHM: Bishal Roy (3rd year) Shreyabhanja Chowdhury (2nd year) Recitation:

Udita Majumder Debate:

Srijita Roy Poushali Ganguly Quiz:

Arani Ray Dipayan Nath Band:

Syantan Ghoswami Anurag Ghosh Atanu Mondal Arka Khamaru Ritobroto Paul Abhirup Dasgupta

Fashion: Md. Nadeem Shah Koustav Sarkar Shaksar Saha Avirup Dasgupta Ranit Kundu Namrata Ganguly Shreyasee Mitra Chandrika Saha

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Debopriya Chatterjee Riya Taran Innovative Modeling:

Ankit Chowdhury Kartik Koley Mudasar Manna Dipan Chaterjee Abhishek Singh Kaustav Pal Manojit Dutta SPIRIT JIS 2015

On 03th to 05th April, 2015 JIS organised SPIRIT JIS 2015. GPAT 2015 Result:

The following B.Pharm. final year students have qualified, GPAT-2015. We congratulate them all. Diksha Kumari Rupanjay Bhattacharya Avik Paul Xtasy 2015: GNIPST is going to organize the Tech Fest ‘Xtasy 2015’ from 30th March, 2015 to 1st April, 2015.

FINISHING SCHOOL TRAINING PROGRAMME: The FINISHING SCHOOL TRAINING PROGRAMME was organized by the Entrepreneurship Development Cell and Training & Placement Cell, GNIPST in collaboration with Indian Pharmacy Graduates’ Association (IPGA), Bengal Branch from 21st February to 11th April, 2015 at GNIPST Auditorium. On 21

st February, 2015 the Finishing School Training Programme of

GNIPST was inaugurated by Sri Soumen Mukhopadhyay, Deputy Director, Drug Control Office, Goutam Kr. Sen, President, IPGA, Mr. Subroto Saha, Asst. Directorate, Drug Control Office, Mr. Ranendra Chakraborty, Sales Manager and Associate Director Dr. Reddys Laboratory.

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On 28th February, 2015 Dr. D. Roy, Former Deputy Drug Controller, Mr. Sujoy Chakraborty, divisional Therapy Manager, Cipla and Mr. Vikranjit Biswas, Senior Manager, Learning & Development, Cipla delivered their valuable lectures in the 2nd day

FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 14th March, 2015 Mr. Milindra Bhattacharya, Senior Manager, QA & QC, Emami Ltd. and Mr. Joydev Bhoumik, Manager, Operation, Ranbaxy Laboratory Limited delivered their valuable lectures in the 3rd day FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 21st March, 2015 Mr. Tridib Neogi, Associate Vice-President (Quality Assurance), Albert David Ltd. delivered his valuable lectures in the 4th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 28th March, 2015 Dr. Gautam Chaterjee, an Alumni of Jadavpur University and presently associated with NIPER delivered his valuable lectures in the 5th FINISHING SCHOOL TRAINING PROGRAMME of GNIPST. On 11th April, 2015 the closing ceremony of the FINISHING SCHOOL TRAINING PROGRAMME was held in GNIPST Auditorium.

JOBS: All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted on 23rd May, 2015 by Standard Pharmaceuticals Ltd. GSK for post: Production, QA, QC. All the students of Final Year B. Pharm and M. Pharm are hereby informed that an interview will be conducted by GSK for sales and marketing job. Details given below:

Date: 27.03.2015Time: 09:45 amVenue : GSK Consumer Healthcare Limited, Unit No. 208,

2nd Floor, Ecospace Campus B (3 B), New Town, Rajarhat, 24 Pgs (N). Kolkata-700156.

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THYROCARE provisionally selected 15 students from JIS Group. Amongst these, 3 students of B. Sc (H) Biotechnology and M. Sc Biotechnology have been selected. Ipsita Mondal (M. Sc Biotechnology)Debriti Paul (M. Sc Biotechnology)Debopriya Chatterjee {B. Sc (H) Biotechnology}

The final year students of B.Pharm (31 students) and B.Sc (11 students) attended the pooled campus drive of Abbott India Ltd. on 10th March, 2015 at Jadavpur University. Among them 17 students have gone through to the final round of this pooled campus drive and short listed for final selection.

ACHIEVEMENT: Congratulations to Anurag Chanda, student of B.Pharm final year

who have got the 1st prize in poster presentation event in Prakriti 2015 at Department of Agricultural and Food engineering, IIT, Kharagpur.

OTHERS: On 24th and 25th February, 2015 Swamiji of Gourio Math wasdelivered some motivational lectuers in GNIPST. The students of GNIPST participated in the 4th Sardar JodhSinghTrophy organised by NIT on 20th February, 2015. On 8th February, 2015 Gnipst celebrated the Reunionprogramme“Reminiscence Reloaded 2015”.

STUDENTS’ SECTION WHO CAN ANSWER FIRST????

The first edition of whichchampionship tournament in tennis

was won by Richard Sears?

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Answer of Previous Issue’s Questions: Vitamin

Identify the person

Answer of Previous Issue’s Image: Frederick Hopkins

Send your thoughts/Quiz/Puzzles/games/write-ups or any other contributions for Students’ Section& answers of this Section at gnipstbulletin@gmail.com

EDITOR’S NOTE

It is a great pleasure for me to publish the 4th issue of 48th Volume of GNIPST BULLETIN. All the followers of GNIPST BULLETIN are able to avail the bulletin through facebook account ‘GNIPST bulletin’ I am very much thankful to all the GNIPST members and readers who are giving their valuable comments, encouragements and supports. I am also thankful to Dr. Abhijit Sengupta, Director of GNIPST for his valuable advice and encouragement. Special thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar and Mr. Soumya Bhattacharya for their kind co-operation and technical supports. Thank you Mr. Soumya Bhattacharya for the questionnaires of the student section. An important part of the improvement of the bulletin is the contribution of the readers. You

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are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

ARCHIVE The general body meeting of APTI, Bengal Branch has been

conducted at GNIPST on 15th June, 2012. The program started witha nice presentation by Dr. Pulok Kr. Mukherjee, School of NaturalProducts, JU on the skill to write a good manuscript forpublication in impact journals. It was followed by nearly two hourlong discussion among more than thirty participants on differentaspects of pharmacy education. Five nonmember participantsapplied for membership on that very day.

GNIPST is now approved by AICTE and affiliated to WBUT forconducting the two years’ post graduate course (M.Pharm)in PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to120.

AICTE has sanctioned a release of grant under ResearchPromotion Scheme (RPS) during the financial year 2012-13toGNIPST as per the details below:a. Beneficiary Institution: Guru Nanak Institution of PharmaceuticalScience & Technology.

b. Principal Investigator: Dr. LopamudraDutta.c. Grant-in-aid sanctioned:Rs. 16,25000/- only

d. Approved duration: 3 years

e. Title of the project: Screening and identification of potentialmedicinal plant of Purulia & Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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Activity Clubs of GNIPST: Name of Club Member Faculty SPORTS Mr. Debabrata GhoshDastidar LITERARY AND PAINTING Ms. Jeenatara Begum SCIENCE AND INNOVATIVE MODELLING

Mr. Samrat Bose

ECO Ms. Sumana Roy SOCIAL SERVICES Dr. Asis Bala PHOTOGRAPHY Ms. Sanchari Bhattacharya CULTURAL Ms. Priyanka Ray DEBATE AND EXTEMPORE Mr. Soumya Bhattacharya

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