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Be healthy for longer
Be free from Health Problems Give
Children a Good Start
Consumer life goals re food
Huge global issues in nutrition
4bn people affected by malnutrition deserve the chance to develop physically & mentally
to get more out of life.
50% of world’s population have blood cholesterol that’s too high.
30% of world’s population have blood pressure that’s too high.
Pop
ula
tion
num
bers
Healthy Unhealthy
Target population for pharma industries
Target population for food industries & public healthcare
Green MR and van der Ouderaa F, Nature Pharmacogenomics - 2003
A vision for improving population health
ETP Food for Life Vision
An effective integration of strategically-focussed, trans-national, concerted
research in the nutritional-, food- and consumer sciences and food chain management will deliver innovative, novel and improved food products for, and to, national, regional and global markets in line with consumer needs and expectations.
These products, together with recommended changes in dietary regimes and lifestyles, will have a positive impact on public health and overall quality of life (‘adding life to years’).
Such targeted activities will support a successful and competitive pan-European agro-food industry having global business leadership securely based on economic growth, technology transfer, sustainable food production and consumer confidence.
European Technology Platform Food for Life
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FoodQuality &
Manu-facturing
Food &Health
Food Safety
SustainableFood Production
Food &Consumer
Communication,Training &
Technology Transfer
Food Chain Management
Stakeholders’ proposal for a Strategic Research Agenda
April, 2006
The key innovation challenges
The development of this ETP has been driven by the activities of its eight Working Groups
To optimize the synergy of its internal interactions, the Stakeholders’ Strategic Research Agenda, SSRA, has been drafted according to the seven Key Challenges for Innovation facing the European agri-food sector
These Challenges map closely with the goals and deliverables of the individual Working Groups
Well-being/appearance
Age
Add life to years
Healthy ageing: Goal
Food & Health
Delivering a healthy diet
Working group: Prof Wim Saris, DMS & Univ Maastricht, NL (chair) Dr Jacqueline Castenmiller, WCFS, NL (fascilitator)
Prof Nils-Georg Asp, LU, SE Prof Robert-Jan Brummer, WCFS, NL Dr Irene Corthesy, CRN, Nestlé, CH Prof Hannelore Daniel, Techn Univ, München, D Dr Gerd Hazer, Kraft, D Dr Ian Johnson, IFR, Norwich, UK Prof Bertold Koletzko, Univ München, D Prof Ian Macdonald, Univ Nottingham,UK Dr Gert Meijer, Unilever, NL Dr Moïse Riboh, Danone, F
METABOLIC FUNCTIONS
IMMUNE- & INTESTINALFUNCTIONS
BRAIN FUNCTIONSINFANT
ELDERLY
life-stage
Food & Health: priority research areas
How did we work?
TOWARDS A STRATEGIC RESEARCH AGENDA FOR FOOD, NUTRITION & HEALTH
• 1. Please define research questions for each cell in the table.
• 2. For each of the research questions, describe:– - (Knowledge) deliverables;– - When to reach these deliverables: 2010, 2015
or 2020;– - Bottlenecks to solve the research questions;– - The breakthrough potential on a scale from 1 to
5 (low to high potential)? This is about the potential of the research to contributing to breakthrough chances or opening up new horizons for application-inspired research.
How did we work? 2
Table. Scientific targets
Life cycle Metabolic function
Immune function Brain function
Cell plasticity Cell plasticity Cell plasticity
In-utero, new-borns, infants and young children
-To optimise development 1
-Early disease prevention – minimising risk for later life 2
-Physical activity 3
-Programming and imprinting 4
-Optimal weaning foods to maximise resistance and to minimise food allergy 5
-Immune tolerance 6
-Nutrition and cognitive function 7
-Brain conditioning (e.g., taste perception) 8
How did we work 3
No.
Research question Knowledge deliverables
Bottlenecks When Break-through potenial
1 Which nutritional factors during pregnancy determine optimal foetal development?
Basis for development of optimal foods/diets
Dietary survey methodology, ethical constraints limiting intervention studies
2015 3
2 How important is caloric excess and macronutrient imbalance for early risk factor development?
Refined recommendations on infant nutrition
Limited possibilities to perform intervention studies
2015 3
Food & Health
Delivering a healthy diet Understanding brain function in relation to diet Understanding dietary effects on immune and
intestinal function Understanding the link between diet and metabolic
function (obesity and associated metabolic disorders)
Understanding consumer behaviour in relation to health and nutrition
Goal 1: Understanding brain function in relation to diet
Diet and cognitive functions Brain conditioning Mood and optimal performance Prevention of cognitive decline Food intake regulation and hunger/satiety Nutrition and interorgan signalling - esp gut-central
nervous system interaction
Goal 2 Understanding dietary effects on immune and intestinal function
Modify systemic inflammatory activity by diet Dietary factors that improve barrier functions Biomarkers for intestinal health Diet before and during pregnancy and lactation -
immunefunction and allergy Improved allergome database for foods
Goal 3 Understanding the link between diet and metabolic function (obesity and associated metabolic disorders
Early biomarkers of metabolic syndrome Individual variations in metabolic energy efficiency Food components that regulate food intake and
increase termogenesis Intervention strategies Counteract age-associated muscle wasting Low-grade inflammation - obesity/insulin
resistance/metabolic syndrome Epigenetic events - chronic disease Maternal and infant recommendations for opt health Meal composition and size - energy uptake, satiety
Goal 4 Understanding consumer behaviour in relation to health and nutrition
Key determinants of food habits Biological determinants in food choice Methodology to understand and quantify determinants Perception and determinants of ”healthy lifestyle” Better tools for effective communication Consumer knowledge - consumer understanding of
health schemes, health claims, simplified labelling - and personalised nutrition based on nutrigenomics
Horizontal Activities
The role of Horizontal Activities is to optimise the impact of the ETP through:
Ensuring internal complementarity: Minimising gaps or duplication across the SRA
Establishing effective links with nationally- and FP6- funded projects, and other ETPsMaximising the effectiveness of European food chain science
Establishing the Mirror Group:Effecting a dialogue with national funding bodies, policy makers and opinion formers, COST, EUREKA, ESF etc
Promoting the ETP: Gaining the support of all European stakeholders
Organising national and regional consultations:Ensuring that the SRA addresses the needs and opportunities of all of Europe
Developing Scenario Studies Raising awareness of long-term challenges and opportunities for the food chain.
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