Dionicio Siegel – Accessing, Understanding, and Optimizing Compounds

We are interested in:

Providing synthetic access to unique compounds with promising biological effects

Determining the mechanism of action of small molecules

Improving the biological performance of compounds, supporting the preclinical advancement of new drug candidates

We have participated in projects focused on CNS injury, prostate cancer,Alzheimer’s, Parkinson’s, antibiotic development, geology, materials, agriculture, assay development, synthetic methods………….

Synthetic Organic Chemistry

Capability to synthesize target compounds

Design and implement synthetic routes to rapidly access analogues

Synthesis of probe molecules for the determination of the mechanism of action of selected compounds

Study the effects of compounds using C. elegans

Proposed Collaborations with SSPPS Faculty

We need new synthetic targets, complex structures with outstanding biological effects

Work with collaborators interested in accessing rare compounds, analogue synthesis, and the preparation of biological probes

We would like to collaborate on the optimization of leads to improve potency, stability, and bioavailability

drsiegel@ucsd.edu