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CURRICULUM VITAE

RICHARD A. CHOLE, M.D., Ph.D.

ADDRESS: Department of Otolaryngology Washington University School of Medicine 660 South Euclid Avenue, Box 8115 St. Louis, MO 63110 Phone (314) 362-7395 (office) (314) 747-4388 (laboratory) (314) 747-1004 (FAX) Email rchole@wustl.edu PRESENT POSITION: Lindburg Professor and Head

Department of Otolaryngology Washington University School of Medicine St. Louis, MO 3/1/1998 – Professor (Primary) Professor, Department of Molecular Biology and Pharmacology

Department of Developmental Biology (newly named 1/2008) Washington University School of Medicine

St. Louis, MO 9/1/98 - Professor (Joint Appointment) Professor, Program in Audiology and Communication Sciences

Washington University School of Medicine St. Louis, MO

7/1/2008 - Professor (Joint Appointment) EDUCATION: Undergraduate University of California, Berkeley

09/62 - 06/65, Undergraduate, Zoology Graduate

University of Southern California, School of Medicine 09/65 - 06/69, M.D. degree Postgraduate

University of Southern California Medical Center, Los Angeles County 06/69 - 06/70, Rotating internship University of Minnesota School of Medicine 07/72 - 06/73, Medical Fellow, Department of Surgery University of Minnesota School of Medicine 07/73 - 01/77, Medical Fellow, Department of Otolaryngology

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University of Minnesota Graduate School 07/73 - 01/77, Ph.D. degree, Otolaryngology (Anatomy-biochemistry track) Sabbatical at the University of Minnesota - training in Transmission Electron Microscopy with Arndt J. Duvall, III, M.D. 04/81 - 06/81 ACADEMIC POSITIONS/EMPLOYMENT:

Southern California Permanente Medical Group Department of Family Practice - Fontana, California 07/70 - 07/72 University of Minnesota School of Medicine, Medical Fellow Department of Surgery, 7/1/1972- 6/30/1973 Department of Otolaryngology, 7/1/1973-12/31/1977

University of California, Davis School of Medicine Department of Otolaryngology - Head and Neck Surgery

01/77 - 06/81, Assistant Professor 07/81 - 06/84, Associate Professor 07/84 - 1/98, Professor 10/85 - 11/85, Acting Chairman 11/85 - 1/98, Chairman Washington University, School of Medicine Department of Otolaryngology - Head and Neck Surgery 3/98 - Present, Lindburg Professor and Head Washington University School of Medicine Department of Molecular Biology and Pharmacology Department of Developmental Biology (newly named 1/2008) 9/1/98 - Professor (Joint Appointment) Washington University School of Medicine Program in Audiology and Communication Sciences 7/1/2008 - Professor (Joint Appointment) UNIVERSITY / HOSPITAL / DEPARTMENTAL APPOINTMENTS AND COMMITTEES: University - University of California-Davis Chancellor's Advisory Committee on the Use of Human Subjects in Clinical and Physiological Research (Institutional Review Board) Member, 1978-1985; Chairman, 1982-1985 University of California Academic Senate: First Alternate, 1978-1980

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Graduate Group in Comparative Pathology Member, 1982-Present; Chairman, Membership Committee, 1988-1993 Interim Steering Committee for the Center for Neurobiology, 1992-1993 School of Medicine/Hospital - University of California-Davis Academic Planning Council, 1991-1998

Ambulatory and Emergency Program Review Committee, 1981-1982 Ambulatory Care Structure Subcommittee, 1988-1991 Ambulatory Care Work Group, 1995-1998 Ambulatory Program Committee, 1977-1981 Ambulatory Surgery Unit Planning Task Force, 1984-1987 Basic Sciences Subcommittee, 1990-1998 Clinical Practices Board, 1991-1998 Clinical Practices Board Contract Work Group, 1996-1998 Clinical Practices Board Executive Committee, 1991-1998 Clinical Programs Administrative Advisory Committee, 1989-1998 Council of Department Chairs Member, 1985-Present; Chairman, 1988

Dean's Recruitment Advisory Committee, 1992-1998

Department of Otolaryngology (ENT) Outpatient Services

Clinical Director, 1984-1998 Information Systems Task Force, Chairman,1993-1998 Management Steering Committee,1982

Medical Records Committee, School of Medicine, Member, 1985-1989; Chairman, 1986-1989

Medical Staff Executive Committee, 1985-1998 Medical Staff Nominating Committee, 1989-1990 Patient Care Audit Subcommittee, 1977-1981 Pharmacy and Therapeutics Committee, 1977-1979

Plan Advisory Committee, School of Medicine, 1985-1986

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School of Medicine Faculty Executive Committee, 1987-1990 School of Medicine Health Sciences Academic Planning Council, 1985-1987 Sierra Regional Eye and Tissue Bank Medical Advisor, 1983-1998 Clinical Director, 1986-1998 UCDMC Cost Management Committee, 1990-1991 UCDMC Medi-Cal Task Force, 1986-1988 Utilization Review Committee, 1977-1979 Veteran's Administration Dean's Committee, 1994-1998 Washington University School of Medicine/Barnes-Jewish Hospital Academic Affairs Committee –Chair, 2002 - 2004 Member 2002 - present

Ex-officio member – 2004 - 2005 Vice Chair, 1998 – 2002

Consultative Work Devoted by Medical School Faculty Committee, 1999 – 2000 Emergency Medicine Task Force – Chair, 2004-2005

Faculty Nepotism Policy Committee - Chairman, 2000 Faculty Diversity Subcommittee of the AAC – Chair, 2002 Faculty Gender Equity Subcommittee of the AAC – 2002 Gender Pay Equity Committee, 2002 Part Time Faculty Policy Subcommittee of the AAC – Chair, 2002 - 2004 Teaching Space Needs at WUSM Committee Administration and Finance Committee, 1998 – 2002, 2004 - 2009 of the Executive Faculty Ambulatory Care Center Committee, 1998 – Present BJH/WUSM Volume Growth and Financial Performance Action Plan Committee

2007 - Present BJC Joint Technology Initiatives Planning Committee, 2000 - Present

Barnes-Jewish Hospital Board of Directors – January, 2005 – December, 2008 Barnes-Jewish Hospital Facilities Committee of the BJH Board of Directors,

2005 - Present Barnes-Jewish Hospital Cares Steering Committee, 1998 - 2000

Barnes-Jewish Hospital Clinical Chiefs Committee, 1998 - Present Barnes-Jewish Hospital Information Technology Strategic Advisory Committee,

2005 - Present

Barnes-Jewish Hospital OR Committee, 1998 – Present

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Barnes-Jewish Hospital OR Executive Committee, 2004 - Present

Barnes-Jewish Hospital Patient Care/Quality Committee, January, 2005 - Present Barnes-Jewish Hospital Physician Advisory Panel, 1998 – 2000 Barnes-Jewish Hospital Physician Billing Compliance Committee, 2007 - Present

Barnes-Jewish Hospital Medical Executive Committee, 1998 - Present Chair – 2005-2007

Barnes-Jewish Hospital Perioperative Steering Committee, 2005 – Present Co-Chair Barnes-Jewish Hospital Resident Clinic Reorganization Steering Committee Billing Compliance Committee (BCC) – WUSM, 2007 – Present Bi-State Medical Gateway Internet Connectivity with Other Medical Schools Committee

CareMaps Oversight Committee (Web EMB), 1999

Central Institute for the Deaf Board of Directors, 2008 – Present Central Institute for the Deaf Ranking Committee, 1998 – Present Central Institute for the Deaf Program Committee, 2008 - Present CID@WUSM Liaison Committee Meeting, 2003 - Present

Clinical Business Committee (CBC) for Otolaryngology

Clinical Research Committee - WUSM Committee on Medical Education (CME) - WUSM Committee on Research Integrity (CRI) – WUSM Community and Population Health Planning Committee – WUSM, 2008 - Present EMR Lite Project Steering Committee, 2000 – 2002 (now eCARE)

EMR Pro-forma Focus Group (Chair)

eCARE Steering Committee, 2002 To Present (replaces EMR Lite Steering Committee) 2000 – 2002

Executive Faculty Committee, 1998 – Present Administrative & Finance Subcommittee, 1998 – 2002; 2004 - 2009

Biochemistry and Molecular Biophysics Chair Search Committee, 2003-2006 Cancer Center Director Search Committee, 1998 - 2001

Division of Clinical Sciences Subcommittee of Executive Faculty, 2001 - Present Executive Committee of the Executive Faculty

Governance Committee, 2004 - Present Internal Medicine Chair Search Committee, 1999 – 2001

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Neurology Chair Search Committee, 2002 – 2003 OB/GYN Chair Search Committee, 2004 - 2005

Ophthalmology Chair Search Committee, 1998 – 2000 Ophthalmology Chair Search Committee, 2011 - Present Radiation Oncology Chair Search Committee, 2002 – 2004 Radiology Chair Search Committee, 2002 - 2003 Research Committee – 2004 - Present Retreat Information Task Force Faculty Practice Plan Board of Directors Committee, 1998 – Present Vice Chair – 2004 – 2006 Chair - 2006 – 2008

Associate Dean of Medical Informatics/Chief Information Officer Search Committee - Chair, 2001 – 2002

wustl.edu Policy Team (email policies) Clinical Information Officer Committee - Chairman, 2000 - 2002

Clinical Information Systems Committee - Chairman, 1999 - 2002 of the Faculty Practice Plan

Consultative Work Time Devoted by Medical School Faculty Subcommittee of the FPP, Chair Work Environment/Abusive Behavior Task Force

Faculty Practice Plan Clinical Practice Committee, 2003 – Present

Chair, 2006 – 2008

Faculty Practice Plan Adhoc Committee – Improving BJH OR Operations Co-Chair Faculty Practice Plan Off-Campus Clinical Development Committee Faculty Diversity Committee, 2010 to Present Faculty Diversity Scholars Program Review Committee, 2010 to Present Research Affairs Committee EMR Data Replication Committee, Physician Executive Sponsor – 2014 Faculty Practice Plan Professional Liability Committee, 1/2005 - Present Faculty Practice Plan Strategic Planning Committee, 1998 – 2000 Faculty Senate Committee

Governance Committee of WUSM, 2004 – Present Human Studies Committee Process Flow and Tracking Initiative Information Security Task Force Committee, 1999 - Present

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Information Technology Executive Advisory Council (ITEAC), 2007 - Present Information Systems Strategy Committee, Chairman, 1998 – Present Institutional Conflict of Interest (ICOI) Committee of WU – 2008 - Present K12/K30/T32 Multidisciplinary Advisory Committee, 2007 - Present

LCME Subcommittee on Clinical Departments, Clinical Teaching Facilities

and Graduate Medical Education, 1998 – Present Pediatric Surgical Services Oversight Committee – 2007 – Present Physical Therapy Doctoral Program Advisory Committee, 1999 Reduced Sign-On (RSO) Steering Committee of BJC & WUSM, 2008 - Present Research Advisory Committee of WUSM, 2008 - Present St. Louis Children’s Credentials Subcommittee, 2007 St. Louis Children’s Hospital Strategic Plan Information Management Subcommittee Security Task Force - WUSM, 1999

Task Force on Non-Compete Strategies Committee, 1999

Task Force on Work Environment/Abusive Behavior, 2000 Tuition Evaluation Committee of the Executive Faculty, 2002

VA Medical Center (John Cochran Division) Affiliation Partnership Council, 1998 - Present

Task Force to Review Research at the STL VA Medical Center, 2002 - Present

Washington University Physician Network Board of Directors (WUPN), 1998 – 2004

WUMC Overall Campus Planning Committee MEDICAL AND BOARD CERTIFICATION: MEDICAL LICENSURE: California, 1970 - G18620 Minnesota, 1972 - 20252 Missouri, 1998 - MD 114392 BOARD CERTIFICATION: American Board of Otolaryngology 09/23/1977 Neurotology Subspecialty Board Certified 4/24/2004

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HONORS AND AWARDS: First Place Award for Basic Research in Otolaryngology American Academy of Ophthalmology and Otolaryngology, 1977 Honors Award for Educational Contributions, American Academy of Otolaryngology- Head and Neck Surgery, 1984 American Otological Society membership 1984 (U.S. membership, 130)

2007 – Received Award of Merit for leadership in research, education and the American Board of Otolaryngology

UCDMC Care Recognition Awards 4/5/88, 6/2/88, 7/20/88, 11/17/88, 11/18/88, 11/19/88, 3/22/89, 3/23/89, 3/31/89, 5/6/91, 6/30/91, 5/19/94

Elected to membership in the Collegium Oto-rhino-laryngologicum Amicitiae Sacrum (ORLAS) September 1991, an international organization of research otolaryngologists, estab. 1926, The Netherlands: worldwide membership - over 300 from 50 countries; 20 members from U.S.

Keynote speaker at the 92nd Japan Oto-Rhino-Laryngological Society Meeting, Fukuoka-City, Japan, May 17, 1991

Organizing committee of the Fourth International Conference on Cholesteatoma and Mastoid Surgery, Niigata City, Japan, September 8-12, 1992

UC Davis School of Medicine Research Award, 1992-93 Selected by fellow physicians to be included in the second edition of The Best Doctors in

America, published by Woodward/White, Inc., Aiken, South Carolina, March, 1994 Keynote speaker at the Dr. S.G. Joshi Memorial Oration of the Association of

Otolaryngologists of India, Udaipur, India, January 10, 1997 Elected to Board of Directors of the American Board of Otolaryngology, 2000.

Elected to Advisory Council of the National Deafness and Other Communication Disorders (NDCD), March 2001 - 2005. Elected to Board of Scientific Counselors,of the U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, June 1, 2006 – June 30, 2010 Barnes-Jewish Hospital Board of Directors, 2005 Elected as American Otological Society Guest of Honor, 2006 Chosen to receive the American Otological Society Award of Merit, 2007 Chosen to receive the Distinguished Service Award from the American Academy of Otolaryngology-Head and Neck Surgery Foundation, September 2008

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Chosen to receive the Presidential Citation from the American Otological Society, Inc. in recognition of his national leadership in education and research and his inspiring example of integrity, humility and generosity, 2013 Chosen to receive the Presidential Citation from the American Neurotology Society, Inc. in recognition of outstanding leadership, personal integrity, and a career dedicated to teaching and research in neurotology, 2014

EDITOR-REVIEWER American Journal of Diseases of Childhood Reviewer, 1986-Present American Journal of Otolaryngology Reviewer, 1988-Present Annals of Otology, Rhinology and Laryngology Reviewer, 1984-Present Journal of the American Medical Association (JAMA) Ad hoc reviewer, 1986-Present Journal for the Association for Research in Otolaryngology (JARO) Reviewer, 2000 - Present Journal of Nutrition Ad hoc reviewer, July 1, 1988-Present Laryngoscope Member, Editorial Board, 1985-Present Otolaryngology-Head and Neck Surgery Executive Editorial Board member, 1990-Present Otology & Neurotology (formerly American Journal of Otology) Editorial Board Member & Reviewer, Present AD HOC REVIEWER National Institute of Deafness and Communication Disorders, Program Project Grant Review Team University of Minnesota Site Visit Ad hoc reviewer, September 26-28, 1995 ADVISORY BOARD Acoustic Neuroma Association, February 1990-Present PROFESSIONAL SOCIETIES AND ORGANIZATIONS: American Academy of Otolaryngology - Head and Neck Surgery

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1978-Present AAO-HNSF Research Advisory Board, 2009 - Present American Board of Otolaryngology Director, 2000-Present

ACGME Residency Review Committee of the American Board of Otolaryngology, 2002-Present

American Laryngological, Rhinological and Otological Society (Triological Society) 1983-Present American Otological Society 1984-Present Council Member, 1998-2002 President-Elect, 2000 President, 2001-2002 American Neurotology Society 1994-Present American Society for Bone and Mineral Research 1988-Present Association of Academic Departments of Otolaryngology - Head and Neck Surgery Council Member, 1984-Present Chair, Education and Match Committee, 1997 - Present Association for Research in Otolaryngology Member, 1985-Present Council Member, 1995-Present President, 1999 California Medical Association Scientific Advisory Panel to the Section on Otolaryngology - Head and Neck Surgery 1986-Present

Collegium Oto-rhino-laryngologicum Amicitiae Sacrum (ORLAS) September 1991 2007 - Vice President, Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum – US Group (CORLAS US)

Chair – CORLAS US Nominating Committee

Sacramento Society of Otolaryngology and Maxillofacial Surgery 1977-Present Society of University Otolaryngologists - Head and Neck Surgeons 1984-Present COMMITTEES National American Academy of Otolaryngology - Head and Neck Surgery Coalition for Hearing & Balance Education Sub-committee (AAO-HNS), 2001 - Present Continuing Education Committee - Otorhinolaryngology Self-Improvement Program Faculty, 1978-1982

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Public and Professional Information Committee, 1980-1983

Equilibrium Subcommittee, 1984-1987 Committee on Research, 1987-1993; Chairman 1992-1993 Research Coordinating Council, 1987-1993

Research Education Committee, 1999 – Present Research Advisory Board of AAO-HNS – 2008 - present

Tinnitus Research Consortium, 2000 - Present

American Otological Society

President, 2001 Trustee of the Research Fund, 1986-1994 Secretary-Treasurer, 1989-1993 Chairman, 1993-1994 Elected as AOS Guest of Honor, 2000 Received Award of Merit, 2007

American Otological Society Membership Development Committee - Chairman, 2000

American Board of Otolaryngology Guest Examiner, Senior Examiner (1999-) 1990, 1991, 1992, 1994, 1997, 1999, 2000 Director, 2000-present Exam Committee – 2002 - Present

Examiner Selection Committee – 2004 - Present Executive Committee of the ABOto, 2002-Present

HMI Committee – 2004 - Present Maintenance of Certification (MOC) Committee, 2000-Present Chair, 2005

Otology/Neurotology Committee, 2000-Present Strategic Long Range Planning (SLRP) Committee, 2000-Present Training Task Force, 2000-Present Residency Review Committee for Otolaryngology, 2002 - 2005

Association of Academic Departments of Otolaryngology-Head and Neck Surgery Education and Match Committee of the AADO - Chairman

Association for Research in Otolaryngology Award of Merit Committee, 1988-1990 President Elect, 1997 President, 1999 Council of the Association for Research in Otolaryngology, 1994 Deafness Research Foundation Scientific Review Committee 1986-1989

National Institute of Deafness and Communication Disorders Communicative Disorders Review Committee (study section)

Member 1989-1993

National Institute of Deafness and Other Communication Disorders and the Department of Veterans Affairs Hearing Aid Clinical Trial

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Data and Safety Monitoring Board Member for CSP #418

1998, 1999 National Institute of Deafness and Communication Disorders Expert Panel on Hearing and Hearing Impairment 1995-Present

National Institute of Deafness and Communication Disorders Concept Clearance Group (CCG), 2001-2004 Temporal Bone Workshop, Chair, 2002-Present

National Institute of Deafness and Communication Disorders National Deafness and Other Communication Disorders (NDCD) Advisory Council Appointed by Secretary of Health, 2001 - 2005

National Institute of Deafness and Communication Disorders/NIH Board of Scientific Counselors Appointed, 2005 - present Otolaryngology Clinical Trial Cooperative Group (OGTCG)

Chair, Bylaws and Procedures Committee, 1998 - Present Subcommittee on the Middle Ear

National Strategic Research Plan for the Hearing and Hearing Impaired 1992 Department of Veterans Affairs Data Safety and Monitoring Board 1995-Present COMMUNITY INVOLVEMENT American Cancer Society Professional Education Committee, 1977-1978 Department of the Air Force David Grant USAF Medical Center (MAC) Travis Air Force Base, CA Staff Consultant, 1981-1990 Greater Sacramento Professional Standards Review Organization, 1978-1979 Sacramento Noise Control Hearing Board, 1977-1991

First Baptist Church, Davis Deacon, 1979-1982 Elder, 1983-1988, 1995-1998

Chair, Building Committee, 1995-Present

St. Louis Bioethics & Culture Committee, 2001 - Present Efree Church, St. Louis, MO Building Committee, 2001 - Present

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MAJOR INVITED PROFESSORSHIPS AND LECTURESHIPS: 1. 1974 LECTURER: "Temporal bone histopathology in experimental hypovitaminosis A,"

Triological Society Meeting, Western Section. 2. 1976 LECTURER: "The endolymphatic sac: Where is it?" Minnesota Academy of

Otolaryngology, Minneapolis, Minnesota, December 10. 3. 1977 INSTRUCTOR: "Fractures of the temporal bone," Course on Maxillofacial Trauma

sponsored by the American Academy of Facial Plastic and Reconstructive Surgery and the Sacramento Society of Otolaryngology and Maxillofacial Surgery, Sacramento, California, April.

4. 1977 LECTURER: "Experimental studies on the role of vitamin A in the inner ear," Research

Forum of the American Academy of Ophthalmology and Otolaryngology, First Award for Basic Research in Otolaryngology, Dallas, Texas, September 30-October 2.

5. 1977 LECTURER: "Diagnosis and treatment of oral lesions," and "Fractures of the temporal

bone," Otolaryngology Update Course, Honolulu, Hawaii, December 6-9. 6. 1978 LECTURER: "The surgical anatomy of the endolymphatic sac," Triological Society

Western Section Meeting, co-author of paper with D. Shea and M. Paparella (Minneapolis), San Francisco, January 28.

7. 1978 PANELIST: "Controversies in the management of otitis media," with the topic of "Chronic

middle ear effusion," UCD Department of Postgraduate Medicine, Common Problems in Ambulatory Pediatrics Course, Sacramento, California, April 7-8.

8. 1978 LECTURER: "Fractures of the zygoma," Maxillofacial Trauma Symposium, UC San

Francisco, April 12-14. 9. 1978 LECTURER: "Squamous metaplasia of middle ear mucosa during vitamin A deprivation,"

POSTER EXHIBIT: "Ulcerative lesions of the oral cavity," POSTER EXHIBIT: "The endolymphatic sac: Its surgical location," American Academy of Ophthalmology and Otolaryngology, Las Vegas, Nevada, September 9-13.

10. 1979 LECTURER: "Ulcerative lesions of the oral cavity," "Brainstem audiometry: Basic

principles," and "A safe approach to the endolymphatic sac," Otolaryngology Update, Honolulu, Hawaii, January 15-18.

11. 1979 LECTURER: "Photography of the tympanic membrane: A new method," PANEL

MODERATOR: "Mucosal disease of the mouth," Pacific Coast Oto-Ophthalmological Society, 63rd Annual Meeting, Monterey, California, May 20-24.

12. 1979 PANELIST: "Monitoring human research," Chancellor's Advisory Committee on the Use

of Human Subjects in Clinical and Physiological Research, University-wide Institutional Review Board, Asilomar, California, September 19.

13. 1979 REPRESENTED THE UNIVERSITY OF CALIFORNIA before the Food and Drug

Administration hearings on the use of human subjects in research, San Francisco, California, October 3.

14. 1980 LECTURER: "Anatomical studies of the posterior petrous apex with regard to hearing

preservation in acoustic neuroma removal," The American Laryngological, Rhinological and Otological Society (American Triological Society), Western Section, Santa Barbara, California, January 25-27.

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15. 1980 LECTURER: "Spontaneous aural cholesteatoma in the Mongolian gerbil," American

Academy of Otolaryngology Annual Meeting, Anaheim, CA, September 28-October 2. 16. 1981 VISITING PROFESSOR: "Cholesteatoma," University of Wisconsin, Madison,

Wisconsin, February 5. 17. 1981 LECTURER: "The gerbilline cholesteatoma," LECTURER: "Quantitative studies of

eustachian tube epithelium during vitamin A deficiency and reversal," Second International Conference on Cholesteatoma and Mastoid Surgery, Tel Aviv, Israel, March 20-28.

18. 1982 LECTURER AND PANELIST: "Upper airway trauma and upper airway access,"

Emergency Medicine 1982 Conference, sponsored by the UCD Division of Critical Care/Emergency Medicine, Department of Internal Medicine and Continuing Medical Education, March 2.

19. 1982 LECTURER: "Temporal bone fractures," Maxillofacial Surgery Course, San Francisco,

California, June 28. 20. 1982 LECTURER: "A morphometric study of the circumvallate papilla during vitamin A

deprivation," American Academy of Otolaryngology-Head and Neck Surgery and the Association for Research in Otolaryngology Annual Meeting Research Forum, New Orleans, Louisiana, October 15.

21. 1983 LECTURER: "Practical brainstem evoked audiometry," "Intratemporal facial nerve

injuries," "Serous otitis media: Why operate?," "Ossicular reconstruction with homograft cartilage," "Management of the burning mouth," "Management of laryngeal injuries." PANELIST: "Serous otitis media," Otolaryngology Update, UCD Department of Otolaryngology and Sacramento Society of Otolaryngology-Head and Neck Surgery, Hawaii, February 2-5.

22. 1983 LECTURER: "Modifications in the management of petrous apicitis," American Otological

Society, 116th Annual Meeting, New Orleans, Louisiana, April 9. 23. 1983 LECTURER: "The basal cell hyperplasia theory of the pathogenesis of cholesteatoma,"

American Triological Society Annual Meeting, New Orleans, Louisiana, May 8. 24. 1983 LECTURER: "Bone resorption in experimental cholesteatoma," Northern California

Society of Military Otolaryngologists, San Francisco, California, July 29. 25. 1983 LECTURER: "Bone erosion in experimental cholesteatoma - the effects of implanted

barriers," Research Forum, PANEL MODERATOR for 10-paper session, American Academy of Otolaryngology, Anaheim, California, October 22 (Authors:Macri J, Chole, R.)

26. 1983 SPEAKER: "Acoustic neuroma," Acoustic Neuroma Society, Sacramento, California,

October 28. 27. 1984 LECTURER: "The basal cell hyperplasia of cholesteatoma," Triological Society Annual

Meeting, Palm Beach, Florida, May 8. 28. 1984 CO-AUTHOR of paper presented by Brian S. Orisek, resident, "Do cholesteatomas exert

pressure?" and PANEL MODERATOR discussing "Otologic problems," Pacific Coast Oto-Ophthalmological Society Annual Meeting, Monterey, California, June 18.

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29. 1984 POSTER PRESENTATION: "Otosclerosis - An animal model" (Chole RA, Henry KR). Also CO-AUTHOR of paper presented by Michael McGinn, Ph.D., "Gerbilline cholesteatoma: Effects on cochlear hair cells. A scanning electron microscope study." American Academy of Otolaryngology Research Forum, Las Vegas, Nevada, September 14-19.

30. 1984 VISITING PROFESSOR: "ENT evaluation of dizziness," UCD Primary Care Lecture,

Nov. 26. 31. 1984 LECTURER: "Clinical philosophy of cholesteatoma management," Stanford University

Department of Otolaryngology Grand Rounds, Stanford, California, December 6. 32. 1985 LECTURER: "Autoradiographic studies of mineral transport from regions of bone

resorption in experimental cholesteatoma," LECTURER: "The use of pre-sculpted homologous cartilage transplants in ossicular replacement," XIII World Congress of Otorhinolaryngology, Miami, Florida, May 29.

33. 1986 POSTER PRESENTATION: "Comparative anatomy of the tympanic membrane and its

relationship to ear disease," POSTER PRESENTATION: "Cellular dynamics in the recruitment of osteoclasts due to pressure effects in the middle ear," Association for Research in Otolaryngology, 1986 Midwinter Meeting, Clearwater Beach, Florida, February 5.

34. 1986 PANELIST: "Institutional review and bioethical considerations," PANELIST: "Otologic

surgery," Second National Conference on Research Goals and Methods in Otolaryngology, Contemporary Methods in Clinical Research, Washington, D. C., April 4.

35. 1986 CO-PRESENTER: "Topical gentamicin prophylaxis in myringotomy and ventilating tube

placement," presented by James Yee; CO-AUTHOR: "Antibiotic prophylaxis for facial fractures: A prospective, randomized trial," with R. Stan Baker, American Academy of Otolaryngology, San Antonio, Texas, Sept. 15.

36. 1986 GUEST LECTURER: "Bone resorption in cholesteatoma," "Petrous apicitis" and "Update

on otitis media with effusion," Oregon Academy of Otolaryngology - Head and Neck Surgery, Portland, Oregon, December 5.

37. 1987 LECTURER: "Fine morphology of bony dysplasia of the murine ear: Comparisons with

otosclerosis;" CO-AUTHOR: "The possible role of immunologic injury in the dysplastic bony lesions in LP/J mice," presented by Hilary Brodie, Association for Research in Otolaryngology, Clearwater Beach, Florida, February 4.

38. 1987 CO-PRESENTER: "The effect of sodium fluoride on the dysplastic bony lesions and

auditory brainstem responses in LP/J mice," with Hilary Brodie, American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, Chicago, Illinois, September 22.

39. 1987 PANELIST: "Research ethics," Regional Workshop on Research Methods in

Otolaryngology, UCLA Conference Center, Lake Arrowhead, California, October 10. 40. 1987 LECTURER: "Assessment and management of post-traumatic hearing loss," Traumatic

Brain Injury: 1987, A Meeting of the Minds-Science and the Injured Brain, Sacramento, California, October 29.

41. 1987 LECTURER: "Cholesteatoma," "Petrositis," "Ossiculoplasty: Cartilage," "Update on otitis

media with effusion" and PANELIST: "Management of cholesteatoma," "Middle ear

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reconstruction," "The diagnosis of acoustic neuroma," San Francisco Otology Update: 1987, San Francisco, California, November 5-6.

42. 1987 GUEST PRESENTATION: "UC Davis Department of Otolaryngology," UCD School of

Medicine, Board of Visitors' Meeting, San Francisco, California, November 13. 43. 1988 POSTER PRESENTATION: "The effects of dexamethasone on the development of the

dysplastic bony lesions in LP/J mice," presented by Hilary Brodie at the 1988 Mid-Winter Meeting of the Association for Research in Otolaryngology, Clearwater Beach, Florida, February 3.

44. 1988 LECTURER: "The role of osteoclasts in diseases of the middle ear: Chronic otitis,

cholesteatoma and otosclerosis," American Otological Society Annual Meeting, Palm Beach, Florida, April 24.

45. 1988 LECTURER: "Mechanisms of osteoclast activation in cholesteatoma," and PANEL

CHAIRMAN, Bone Resorption Section. CO-AUTHOR: "Spontaneous cholesteatoma in gerbils: Studies of pathogenesis," (presented by Steven P. Tinling), Third International Conference on Cholesteatoma and Mastoid Surgery, University of Copenhagen, Copenhagen, Denmark, June 6.

46. 1989 LECTURER: "Air pressure induced bone remodeling: A quantifiable model of localized

bone resorption," 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, Nevada, February 6.

47. 1989 VISITING PROFESSOR: "Otosclerosis - animal models," "Bone resorption due to

cholesteatoma" and "Ossicular reconstruction - Cartilage TORP's and PORP's," Harvard School of Medicine, Department of Otolaryngology Program, April 18-19.

48. 1989 INVITED LECTURER: "Evaluation and treatment of conductive hearing loss in children,"

Pediatric ENT Update, sponsored by Sutter Health, Sacramento Pediatrics Society, and the Sacramento Society of Otolaryngology/Head and Neck Surgery, May 20.

49. 1989 KEYNOTE SPEAKER: "Acoustic neuroma: what's new?", Eighth Annual Acoustic

Neuroma Association Symposium, Sacramento, California, July 15. 50. 1989 SPEAKER: "Acoustic neuroma: treatment options," workshop at Eighth Annual Acoustic

Neuroma Association Symposium, Sacramento, California, July 15. 51. 1989 GUEST LECTURER: "Petrous apicitis" and "Bone erosion in cholesteatoma," resident

lectures at San Diego Naval Hospital, Department of Otolaryngology-Head and Neck Surgery, San Diego, California, October 19.

52. 1989 GUEST LECTURER: "PORP's and TORP's," San Diego Academy of Otolaryngology,

San Diego, California, October 19. 53. 1989 GUEST FACULTY: "Cholesteatoma," "Petrositis," "Ossiculoplasty," "Update on Otitis

Media with Effusion." PANELIST: "Infectious Ear Diseases" (moderator), "Middle Ear Reconstruction," "Cochlear Hearing Loss," "Pediatric Otology." San Francisco Otology Update: 1989, San Francisco, California, November 2-4.

54. 1990 CO-PRESENTER with Michael C. Jungkeit, MS IV, presenter, "Ibuprofen inhibits

localized bone resorption," Mid-winter Meeting, Association for Research in Otolaryngology, St. Petersburg Beach, Florida, February 6.

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55. 1990 LECTURER: "Assuring equivalence in resident surgical training," Society of University Otolaryngologists, San Francisco, October 7.

56. 1991 VISITING PROFESSOR: "Cholesteatoma," "Otitis Media," Oakland Kaiser Permanente,

Department of Otolaryngology, January 25, Oakland, CA. 57. 1991 PROGRAM COMMITTEE MEMBER: Cherry Blossom Conference, "Winning Research

Grants in the 90's." LECTURE: "Protection of Research Subjects." PANEL MEMBER: "Workshop on Writing Applications," Washington, D.C., March 9.

58. 1991 CO-PRESENTER: "Hereditary giant platelet disorder with associated progressive

deafness," Combined Otolaryngological Spring Meetings, Waikoloa, Hawaii, May 5. 59. 1991 VISITING PROFESSOR: "Petrous Apicitis," Department of Otolaryngology, Niigata

University, School of Medicine, Niigata, Japan, May 13. 60. 1991 KEYNOTE SPEAKER/INVITED LECTURER: "Biological Control of Bone Resorption in

the Middle Ear - Clinical Importance," Japan Otolaryngological Society, Fukuoka, Japan, May 17.

61. 1991 CO-PRESENTER with Martha Corcoran, M.D.: "Diffuse neurofibroma of the head and

neck," American Academy of Otolaryngology - Head and Neck Surgery, Kansas City, MO, September 21.

62. 1991 CO-PRESENTER with Ann Richardson, M.D.: "Congenital lip pits," American Academy

of Otolaryngology - Head and Neck Surgery, Kansas City, MO, September 21. 63. 1991 CO-INSTRUCTOR with Kevin McKennan, M.D.: "Biology and treatment of

cholesteatoma," American Academy of Otolaryngology - Head and Neck Surgery, Kansas City, MO, September 22.

64. 1992 CO-CHAIR and PRESENTER: "1) Sensorineural hearing loss; 2) Otitis media; and 3)

Rehabilitation strategies for the hearing impaired," National Institute on Deafness and Other Communication Disorders, Subcommittee on the Middle Ear, National Strategic Research Plan for the Hearing and Hearing Impaired, Bethesda, MD, January 21-22.

65. 1992 LECTURER: "Incomplete coverage of bone matrix within the mammalian cochlea,"

Association for Research in Otolaryngology Winter Meeting, St. Petersburg, FL, February 3.

66. 1992 VISITING PROFESSOR: "1) The use of cartilage PORPs and TORPs in ossicular

reconstruction; 2) New insights into the pathophysiology of otosclerosis; and 3) Diagnosis and management of petrous apicitis," Satellite Mini-Symposium of "Recent Advances in Otology," Korean Otologic Study Group, Seoul, Korea, September 5.

67. 1992 INVITED LECTURER: "Mechanisms of bone erosion in aural cholesteatoma;" PANEL

MODERATOR: "Animal Experiment;" PANEL DISCUSSANT: "The Gerbil Model of Acquired Cholesteatoma;" Fourth International Conference on Cholesteatoma and Mastoid Surgery, Niigata, Japan, September 10.

68. 1992 VISITING PROFESSOR: "Mechanisms of pathological bone resorption," Department of

Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan, September 14.

69. 1992 LECTURER: "Osteoclasts and bone lining cells: a role in ear disease," First Annual

Updates in Biomedical Research and Teaching Symposium, UCDMC, October 27, 1992.

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70. 1993 PANELIST: Consensus Development Conference on "Early identification of hearing

impairment in infants and young children," National Institutes of Health, Office of Medical Applications of Research, Bethesda, Maryland, March 1-3.

71. 1993 VISITING PROFESSOR: "Localized bone resorption in middle ear disease," and

"Petrous apicitis," Manhattan Eye, Ear and Throat Hospital, Department of Otolaryngology - Head and Neck Surgery, New York, March 25-26.

72. 1993 INVITED LECTURER: "Petrous apicitis," and "Ossicular reconstruction - cartilage

TORPS and PORPs," First National Kaiser Permanente Otolaryngology Head & Neck Surgery Symposium, Maui, Hawaii, June 28-July 1.

73. 1993 INVITED LECTURER: "Cholesteatoma and otitis media," Recent Advances in Otitis

Media Symposium, Minneapolis, Minnesota, October 1. 74. 1993 GUEST FACULTY: "Petrous apicitis," "Cartilage (PORPs and TORPs)," "Temporal bone

trauma: otalgia." PANELIST: "Infectious ear disease - audience question session," "Middle ear reconstruction - audience question session." San Francisco Otology, Neurotology, and Skull Base Update: 1993, San Francisco, California, November 4-6.

75. 1993 LECTURER: "Cellular regulation of bone remodelling," Orthopaedic Research

Conference, University of California, Davis, Medical Center, Orthopaedics Department, Sacramento, California, California, November 16.

76. 1994 GUEST FACULTY: "Indications for ENT surgery in pediatrics: PE tubes,

adenoidectomies and tonsillectomies," 1994 Annual Winter Meeting, California Chapter 1, American Academy of Pediatrics, San Francisco, California, January 15.

77. 1994 VISITING PROFESSOR: "Mechanisms of bone remodeling in the temporal bone," 12th

Annual Otolaryngology Scientific Forum, Wayne State University, Department of Otolaryngology, Detroit, Michigan, March 12.

78. 1994 LECTURER: "Identification of hearing impairment in infants and young children,"

California Speech and Hearing Association, Annual Conference, Sacramento, California, March 18.

79. 1994 LECTURER: "Antimicrobial activity of silver oxide impregnated silicone elastomer

tympanostomy tubes: a randomized multicenter trial," 127th Meeting of the American Otological Society, Palm Beach, Florida, May 8.

80. 1994 LECTURER: "Cellular aspects of chronic otitis media," 2nd Annual Distinguished Alumni

Lecture, University of Minnesota, Minneapolis, Minnesota, June 9. 81. 1994 INVITED LECTURER: “The role of messenger peptides in the control of localized

remodeling in the middle ear,” Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum, Estoril, Portugal, September 3-7.

82. 1994 VISITING PROFESSOR: “Trouble with tubes - use of tympanostomy tubes for otitis

media,” Otorhinolaryngology Monthly Conference, Southwestern Medical Center, The University of Texas, Dallas, Texas, November 4.

83. 1995 VISITING PROFESSOR: “Tube trouble: tympanostomy tubes in 1995," Minnesota

Academy of Otolaryngology Head and Neck Surgery, 6th Midwinter Conference, Minneapolis, Minnesota, January 13-14.

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84. 1995 VISITING PROFESSOR: “Bone remodeling and middle ear disease,” The Cleveland Clinic Foundation, Department of Otolaryngology and Communicative Disorders, Cleveland, Ohio, April 12.

85. 1995 LECTURER: “Activent™ antimicrobial ventilation tube” - Xomed Surgical Products.

Society of Otolaryngology - Head & Neck Surgery Annual Meeting, June 27. 86. 1995 LECTURER: “Activent™ antimicrobial ventilation tubes: results of a double-blind

randomized multi-center trial” - Xomed Surgical Products Breakfast, September 18. 87. 1995 LECTURER: “Trouble with tubes” and “Otologic manifestations of TMJ dysfunction,” The

San Francisco Otology & Neurotology Update on November 2-4. 88. 1995 LECTURER: “Petrous apicitis,” University of San Francisco Departmental Grand

Rounds Conference, December 11. 89. 1996 LECTURER: “Trouble with tubes: a discussion of myringotomy tubes and their inherent

complications,” and “Cartilage, TORPS and PORPS,” and “Extended mastoidectomy including petrous apex,” San Diego Academy of Otolaryngology - Head & Neck Surgery, February 15-16.

90. 1996 INVITED LECTURER: “Anesthetic considerations in otologic and neurologic surgery” and

“Avoiding catastrophe in airway surgery,” American Association of Nurse Anesthetists, 63rd Annual Meeting, Philadelphia, Pennsylvania, August 10-13.

91. 1997 INVITED LECTURER: “Use of homologous and autologous cartilage in ossicular

reconstruction,” 49th Annual Conference of the Association of Otolaryngologists of India, Udaipur, India, January 9.

92. 1997 INVITED LECTURER: “Diagnosis and management of suppurative disease of petrous

apex” and “The use of tympanostomy tubes for otitis media,” 49th Annual Conference of the Association of Otolaryngologists of India, Udaipur, India, January 10.

93. 1997 INVITED LECTURER: “The cellular and molecular biology of otosclerosis,” 49th Annual

Conference of the Association of Otolaryngologists of India, Udaipur, India, January 11. 94. 1998 VISITING PROFESSOR: “Petrous Apicitis” and “Bone Resorption in Chronic Otitis

Media-New Developments,” University of Iowa, March 26-28. 95. 1998 VISITING PROFESSOR: “Osteoclast Function in Bone Resorption” and “Adaptive Bone

Modeling in the Middle Ear Is Substance-p Dependent,” Seminar on Cholesteatoma, University of Bochum, St. Elisabeth Hospital, Germany, November 17.

96. 1999 LECTURER: "Bone Cells and Deafness," Joint Research Seminar, WUSM Department

of Otolaryngology/Central Institute for the Deaf, St. Louis, MO, January 8. 97. 1999 VISITING PROFESSOR: "Compensation Plan," Southern Illinois University, March 5. 98. 1999 LECTURER: "Bone Remodeling and Deafness," Barnes-Jewish Hospital, Bone Conference, St. Louis, MO, March 19. 99. 1999 LECTURER: "Bone Lining Cells of the Cochlea and Other Places," Joint Research Seminar, WUSM Department of Otolaryngology/Central Institute for the Deaf, St. Louis, MO, April 2. 100. 1999 INVITED GUEST LECTURER: "Troubles with Tubes - Tympanostomy Tube Update

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1999" and “Management of Petrous Apicitis,” Missouri Society of Otolaryngology, Tantara, MO, April 10. 101. 2000 PANEL DISCUSSION: "Training Issues of the Next General of Otolaryngologists,"

University of Iowa, April 27-29.

102. 2000 ROUND TABLE PANEL: "Pathogenesis of Cholesteatoma: Controversial Aspects," 6th International Conference on Cholesteatoma & Ear Surgery - Cannes, France, June 29 - July 2.

103. 2000 COURSE PRESENTER: "Tympanoplasty and Ossiculoplasty," at the AAO-HNS Annual

Meeting, Washington, DC, September 24-27. 104. 2001 COURSE PRESENTER: "Tympanoplasty and Ossiculoplasty," at the AAO-HNS Annual

Meeting, Denver, CO, September 9-12. 105. 2001 INVITED GUEST PRESENTER: "Recruitment of Specialists," at the SUO-HNS/AADO

Annual Meeting Management Seminar, Washington, DC, November 2-4. 106. 2002 INVITED GUEST LECTURER: “Microbial Biofilms in Otolaryngology,” “Cholesteatoma

Pathogenesis: Evidence for Migration and Retraction Theories,” “Petrous Apicitis: Clinical Approaches,” at the Second Annual Charleston Magnolia Conference at the Medical University of South Carolina, May 30 – June 1.

107 2002 INVITED GUEST LECTURER: “Microbial Biofilms in Otolaryngology – A Mechanisms of Persistent Infection,” at the 3rd Annual Otolaryngology Alumni Day and 15th Annual Roger H. Lehman, MD Lecture, Medical College of Wisconsin, June 14, 2002

108. 2002 INVITED GUEST LECTURER: “The Changing Face of Petrous Apicitis,” Microbial Biofilms in Otolaryngology” at the Albert Einstein College of Medicine Graduation Lecture, Montefiore Medical Center, June 26 – 28.

109 2002 LECTURER: “Microbial Biofilms in Cholesteatomas” at the Collegium Oto-Rhino-

Laryngologicum Amicitiae Sacrum, Noordwijk, the Netherlands, August 25 –29. 110. 2002 COURSE PRESENTER: "Tympanoplasty and Ossiculoplasty," at the AAO-HNS Annual

Meeting, San Diego, CA, September 21-25. 111. 2002 INVITED GUEST PRESENTER "Keys to success in different types of institutions" at the

SUO-HNS/AADO Annual Meeting, Scottsdale, AZ, October 26-27.

112. 2002 INVITED GUEST LECTURER: "Osteoclast activation and control in inflammatory ear disease" and “Bacterial biofilm in cholesteatoma” at the University of Wisconsin Basic Science Seminar, November 8-9, 2002. 113. 2003 INVITED GUEST LECTURER: “The role of bacterial biofilms in Otolaryngology” and “The changing face of petrous apicitis” at the University of Virginia, February 27.

114. 2004 INVITED GUEST LECTURER: “Bacterial biofilms in Otolaryngology - The basis of

chronic infections” and “The changing face of petrous apicitis” at the University of California-San Francisco, June 25-26.

115. 2004 CO-PRESENTER with David Molter, MD "Taming the Digital Image Workflow" at the

Annual Academy of Otolaryngology-Head & Neck Surgery Annual Meeting, New York, NY, September 17-22.

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116. 2004 INVITED GUEST LECTURER: “Bacterial Biofilms in Otitis” at the LXI Congreso Chileno de Otorrinolaringolologia Medicina y Ciruigia de Cabeza y Cuello, Valdivia, Chile, November 10-13.

117. 2004 INVITED GUEST LECTURER: “Middle Ear Surgery (Part I)” at the LXI Congreso Chileno de Otorrinolaringolologia Medicina y Ciruigia de Cabeza y Cuello, Valdivia, Chile, November 10-13.

118. 2004 INVITED GUEST LECTURER: “Middle Ear Surgery (Part II)” at the LXI Congreso

Chileno de Otorrinolaringolologia Medicina y Ciruigia de Cabeza y Cuello, Valdivia, Chile, November 10-13.

119. 2004 INVITED GUEST LECTURER: “Petrositis: Diagnosis & Management” at the LXI

Congreso Chileno de Otorrinolaringolologia Medicina y Ciruigia de Cabeza y Cuello, Valdivia, Chile, November 10-13.

120. 2004 ROUND TABLE PANELIST: “Middle Ear Surgery” at the LXI Congreso Chileno de

Otorrinolaringolologia Medicina y Ciruigia de Cabeza y Cuello, Valdivia, Chile, November 10-13.

121. 2004 INVITED LECTURER: “Why the Six Competencies” at The Society of University

Otolaryngologists and The Association of Academic Departments of Otolaryngology Annual Meeting, Las Vegas, NV, November 19-21.

122. 2004 INVITED LECTURER: “Hearing Loss” at the Society of Professors Emeriti luncheon at

Whittemore House of Washington University, December 13. 123. 2005 INVITED GUEST LECTURER: “Biofilm Disease in Otolaryngology – A Mechanisms of

Chronic Infection” at Loyola University, Department of Otolaryngology, January 18-19. 2005.

124. 2005 INVITED GUEST LECTURER: “Pseudomonas aeruginosa – Mechanisms of Pathology

in Chronic Otitis” at Loyola University, Department of Otolaryngology, January 18-10, 2005.

125. 2005 INVITED GUEST LECTURER: “Pathophysiology of cholesteatoma: The role of

Pseudomonas aeruginosa” at the Center for Genomic Sciences Seminar Series, Allegheny General Hospital, January 31, 2005.

126. 2005 INVITED GUEST LECTURER: “Biofilm disease in Otolaryngology” at Indiana University

School of Medicine at the 21st Annual Manion-Lingeman Lecture and Research Seminar, Department of Otolaryngology, May 27, 2005.

127. 2005 INVITED GUEST LECTURER: “The role of microbial biofilms in persistent

otolaryngological infections” at The University of Texas Medical School at Houston, Department of Otolaryngology Grand Rounds, July 7, 2005.

128. 2005 INVITED GUEST LECTURER: "The Opportunities & Limitation of a Training Grant" at

the Conference on Research Education & Training in Otolaryngology - Washington, DC, November 2, 2005.

129. 2006 INVITED GUEST LECTURER: “Bacterial biofilms – A mechanism of tissue; destruction

in chronic ear disease” as the 11th Maxwell Abramson Memorial Lecturer at Columbia University, April 20, 2006.

130. 2006 INVITED GUEST LECTURER: “Cholesteatoma Pathophysiology” as the 11th Maxwell

Abramson Memorial Lecturer at Columbia University, April 20, 2006.

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131. 2006 INVITED GUEST LECTURER: "Biofilms - Medical Challenges in Otolaryngology" as the

Percy Ireland Lecturer at the University of Toronto, May 4, 2006. 132. 2006 INVITED GUEST LECTURER: "The Pathophysiology of Pseudomonas Biofilms in Aural

Cholesteatomas" as the Annual Percy Ireland Oration at the University of Toronto, May 5, 2006.

133. 2006 AOS GUEST OF HONOR: "Bacterial Biofilms: The Source of Tissue Destruction in

Cholesteatomas? at the 2006 AOS 130th Annual Spring Meeting, Chicago, IL, May 20, 2006.

134. 2006 INVITED GUEST LECTURER: John Kemink Lectureship - "The pathogenesis of chronic

infection in otology: The role of biofilms" at University of Michigan (Michigan-Work Society Meeting), Ann Arbor, MI – October, 20, 2007.

135. 2007 INVITED GUEST LECTURER: "Ethical issues surrounding stem cell research",

Louisville, KY, University of Louisville & University of Kentucky keynote speaker, May 18, 2007.

136. 2007 INVITED GUEST LECTURER: Martinez Lecturer - "The Challenge of Controlling

Biofilms in Chronic Otolaryngological Infections", Louisville, KY, Kentucky Society of Otolaryngology, May 19, 2007.

137. 2007 INVITED GUEST LECTURER: "Biofilm Diseases and Otolaryngology" at 301 Hospital,

Peking, China, May 29, 2007. 138. 2007 INVITED GUEST LECTURER: "Biofilm Disease and Otolaryngology" at Shanghai

University, Shanghai, China, June 1, 2007. 139. 2007 INVITED GUEST LECTURER: "Evaluation & Management of Vertigo" at SOHN Mtg -

Marriott at Metro Center Hotel, Washington, DC, September 17, 2007. 140. 2007 INVITED GUEST LECTURER: "Otology: What I have learned that you will never read

about” at the University of Cincinnati, October 16, 2007. 141. 2007 INVITED GUEST LECTURER: "Bacterial Biofilm Disease in Otolaryngology” to

Cincinnati ENT Society, October 18, 2007. 142. 2007 PANEL MODERATOR: "Who's an author anyway? Understanding issues of

professionalism in medial research" at the Society for University Otolaryngologist-Head & Neck Surgeons & AADO Meeting in Washington, DC, November 3, 2007.

143. 2008 INVITED LECTURER: Otitis media and biofilms - "Bedside to Bench and Back,

Challenging Conventional Wisdom" at “short course” at the 31st Annual ARO Midwinter Meeting, Phoenix, AZ, February 16, 2008.

144. 2008 INVITED WILLIAM F. HOUSE LECTURER – “Scala Tympani Electrode Insertion:

Techniques & Outcomes” at the American Neurotological Association at the Combined Otolaryngologic Spring Meeting, Orlando, FL, May 2, 2008.

145. 2008 INVITED PRESENTER: “Surgery for Chronic Otomastoiditis: State of the Art” at the

Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery Foundation Miniseminar, Chicago, IL, September 23, 2008.

146. 2009 INVITED PRESENTER: “Evaluation of the Vertiginous Patient” at the 2009 UC Irvine

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Otolaryngology Updates, Palm Springs, Palm Desert Rancho Mirage, February 16, 2009. 147. 2009 INVITED PRESENTER: “Advances in Cochlear Implantation” at the 2009 UC Irvine

Otolaryngology Updates, Palm Springs, Palm Desert Rancho Mirage, February 16, 2009. 148. 2009 INVITED PRESENTER: Bacterial Biofilms in Otolaryngology” at the 2009 UC Irvine

Otolaryngology Updates, Palm Springs, Palm Desert Rancho Mirage, February 17, 2009. 149. 2009 INVITED PRESENTER: “Improving Outcomes of Canal Down Mastoidectomy” at the

2009 UC Irvine Otolaryngology Updates, Palm Springs, Palm Desert Rancho Mirage, February 17, 2009.

150. 2009 INVITED PRESENTER: “Maintenance of Certification in Otolaryngology” at the 2009 UC

Irvine Otolaryngology Updates, Palm Springs, Palm Desert Rancho Mirage, February 16, 2009.

151. 2010 INVITED GUEST LECTURER: “Why is it so difficult to cure ear infections? A decade of

biofilm research.” 2nd Annual Paparella Award and Lectureship, University of Minnesota, April 12, 2010.

152. 2010 VISITING PROFESSOR: “Indolent infections in Otolaryngology: The biofilm story” at the

Ninth Annual Lectureship in Otolaryngology & Communicative Sciences and Resident Graduation at the University of Mississippi Medical Center, June 25, 2010.

153. 2010 VISITING PROFESSOR: “Cochlear Implantation: Can We Improve?” at the Ninth Annual

Lectureship in Otolaryngology & Communicative Sciences and Resident Graduation at the University of Mississippi Medical Center, June 25, 2010.

154. 2010 INVITED GUEST SPEAKER: “Hearing Preservation in Children” at the 3rd International

Electric-Acoustic Cochlear Implant Workshop, hosted by University of Iowa and sponsored by Cochlear America, October 3-4, 2010.

154. 2010 INVITED GUEST SPEAKER: “Electrode Positioning on Imaging” at the 3rd International

Electric-Acoustic Cochlear Implant Workshop, hosted by University of Iowa and sponsored by Cochlear America, October 3-4, 2010.

155. 2010 INVITED PANEL PARTICIPANT: Tensions and Conflicts Created by Decreasing

Financial Resources for Academic Medicine”, at the Society of University Otolaryngologists Annual Meeting in Scottsdale, AZ, November 13, 2010.

156. 2010 INVITED GUEST LECTURER: “Resident Applicant Selection – How Do We Really

Know?” at the Otolaryngology Program Director’s Meeting at the Society of University Otolaryngologist-Association of Academic Department of Otolaryngology (SUO-AADO) Annual Meeting in Scottsdale, AZ, November 13-14, 2010.

157. 2011 INVITED GUEST JAMES PARKIN LECTURER: “Microbial biofilms in Otolaryngology” at

the 17th Annual Utah Otolaryngology Update, Salt Lake City, UT June 24-25, 2011. 158. 2011 INVITED GUEST JAMES PARKIN LECTURER: “Advice to doctors from an old

department chairman” at the 17th Annual Utah Otolaryngology Update, Salt Lake City, UT June 24-25, 2011.

159. 2011 INVITED GUEST JAMES PARKIN LECTURER: “Have we done an adequate job in

selecting students for residency training in Otolaryngology?” at the 17th Annual Utah Otolaryngology Update, Salt Lake City, UT June 24-25, 2011.

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160. 2011 INVITED PANEL PARTICIPANT: “Making research time productive: at the SUO-AADO / Otolaryngology Departments Program Directors Meeting, November 11, 2011.

161. 2012 INVITED JAHRSDOERFER VISITING PROFESSOR: “Biofilms in Otolaryngology: A

Microbe’s Little Secret!” April 11-13, 2012. 162. 2012 INVITED SESSION MODERATOR: "Electrode Design/Function" (Sessions #38-44) at

12th International Conference on Cochlear Implants and Other Implantable Auditory Technologies, Baltimore, MD, May 3-5. 2012.

163. 2012 INVITED GUEST PRESENTER: "Conductive Hearing Loss after Cochlear Implantation"

at 12th International Conference on Cochlear Implants and Other Implantable Auditory Technologies, Baltimore, MD, May 3-5. 2012.

164. 2012 INVITED GUEST PRESENTER: “The Role of Microbial Biofilms in Chronic Ear Disease” Grand Rounds at University of Pittsburgh Eye and Ear, July 23-25, 2012. 165. 2012 INVITED PRESENTER: "Conductive hearing loss after cochlear implantation" at the

Collegium Oto-Rhinolaryngologicum Amicitiae Sacrum, Rome, Italy, August 24, 20, 2012. 166. 2012 INVITED GUEST PRESENTER: “Bacterial Biofilms: In the Sea and in Otolaryngology” 6th International Update Course: Otolaryngology Underwater, Cayman Brac, December 3-

8, 2012 167. 2012 INVITED GUEST PRESENTER: “Advances in Minimally Invasive Cochlear Implantation”

6th International Update Course: Otolaryngology Underwater, Cayman Brac, December 3-8, 2012

168. 2012 INVITED GUEST PRESENTER: “Cartilage Tympanoplasty” 6th International Update

Course: Otolaryngology Underwater, Cayman Brac, December 3-8, 2012 169. 2012 INVITED GUEST PRESENTER: “Do Medical Student Grades Predict Success as a

Doctor” 6th International Update Course: Otolaryngology Underwater, Cayman Brac, December 3-8, 2012

170. 2012 INVITED PANEL PARTICIPANT: “Workforce Issues and Training in Otolaryngology” 6th

International Update Course: Otolaryngology Underwater, Cayman Brac, December 3-8, 2012

171. 2012 INVITED PANEL PARTICIPANT: “What is New and Exciting in my Area” 6th

International Update Course: Otolaryngology Underwater, Cayman Brac, December 3-8, 2012

172. 2013 INVITED GUEST PRESENTER: "Bacterial biofilms - A cause of recalcitrant infections of

the human temporal bone" at the Festschrift Honoring Joseph Nadol, MD, Massachusetts Eye & Ear Infirmary, June 12, 2013

173. 2013 INVITED GUEST GRADUATION LECTURER: "Bacterial Biolfilms: Are Bacteria a Higher

Form of Life?" University of Colorado-Denver, June 14, 2013 174. 2013 INVITED GUEST GRADUATION LECTURER: “Advice to Young Doctors.” University of

Colorado-Denver, June 14, 2013 175. 2013 INVITED FRANKLIN M. RISER LECTURER: “The Chronicity of Otitis: the Role of

Bacterial Biofilms”, American Neurotology Society Fall Scientific Meeting, AAO-HNSF Annual Meeting, Vancouver, BC, September 28, 2013

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176. 2013 INVITED GUEST LECTURER: "Evolution of a concept - Biofilms and Otology," Pre-

Congress Day, 43rd Brazilian National Congress Meeting, Sao Paulo, Brazil, November 20, 2013

177. 2013 INVITED ROUD TABLE DISCUSSANT AND MODERATOR: “Surgical decisions on

chronic otitis media,” 43RD Brazilian National Congress Meeting, Sao Paulo, Brazil, November 20, 2013

178. 2013 INVITED GUEST LECTURER: "Ongoing research projects," 43RD Brazilian National

Congress Meeting, Sao Paulo, Brazil, November 21, 2013 179. 2013 INVITED GUEST LECTURER: “Unilateral sensor neural hearing loss-etiology and

treatment," 43RD Brazilian National Congress Meeting, Sao Paulo, Brazil, November 21, 2013

180. 2013 INVITED ROUND TABLE DISCUSSANT AND MODERATOR: “Ossicular

reconstruction,” 43rd Brazilian National Congress Meeting, Sao Paulo, Brazil, November 21, 2014

RESEARCH SUPPORT: Government National Institutes of Health 1) A) EXPERIMENTAL CHOLESTEATOMA B) HEARING LOSS IN THE AGING MOUSE National Institutes of Neurological and Communicative Disorders and Stroke Teacher-Investigator Development Award K07 NS00396 - Principal Investigator 01 1979-1980 $44,172 Total: $220,860 02 1980-1981 44,172 03 1981-1982 44,172 04 1982-1983 44,172 05 1983-1984 44,172 2) AUDITORY DEFICITS IN THE AGING MOUSE National Institute of Aging Grant R01 AGO1018 - Co-Investigator (Principal Investigator: Kenneth R. Henry, Ph.D.) 01 1978-1979 $45,515 Total: $95,705 02 1979-1980 24,390 03 1980-1981 25,800 3) AURAL CHOLESTEATOMA - AN EXPERIMENTAL MODEL National Institute of Neurological and Communicative Disorders and Stroke Grant R01 NS17208 - Principal Investigator 01 1981-1982 $83,524 Total: $195,608 02 1982-1983 55,701 03 1983-1984 56,383

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4) MECHANISMS OF TISSUE DESTRUCTION IN CHOLESTEATOMA National Institute of Neurological and Communicative Disorders and Stroke Grant R01 NS21079-03 change to DC00263 - Principal Investigator 01 1985-1986 $118,861 Total: $331,428 02 1986-1987 100,538 03 1987-1989 112,029 5) OTOSCLEROSIS-LIKE LESIONS IN THE LP/J MOUSE National Institute of Neurological and Communicative Disorders and Stroke Grant R01 NS21573-01 - Principal Investigator 01 1985-1986 $103,879 Total: $272,132 02 1986-1987 79,007 03 1987-1989 89,246 6) MECHANISMS OF TISSUE DESTRUCTION IN THE MIDDLE EAR National Institute on Deafness and Other Communication Disorders Grant R01 DC00263-08 - Principal Investigator 04 1989-1990 $171,363 Total:$1,000,445 05 1990-1991 178,217 06 1991-1992 185,347 07 1992-1993 227,140 08 1993-1994 238,378 7) CELLULAR BIOLOGY OF CHOLESTEATOMA National Institute on Deafness and Other Communication Disorders Grant R01 DC00263-11 - Principal Investigator 09 1994-1995 $267,989 Total: $875,690 10 1995-1996 299,442 11 1996-1997 308,259 8) CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA National Institute on Deafness and Other Communication Disorders Grant R01 DC00263-16 - Principal Investigator *12 1998-1999 $342,824 Total: $1,845,603 13 1999-2000 353,109 14 2000-2001 363,702 15 2001-2002 374,614 16 2002-2003 411,354 *Data is not available on line or in house any more. This is estimated based on the fact that NIH did not reduce awards during that period of time and increased awards steadily 3% each year. 9) CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA National Institute on Deafness and Other Communication Disorders

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Grant R01 DC00263-21 - Principal Investigator 17 2003-2004 $336,018 Total: $1,695,557 18 2004-2005 348,075 19 2005-2006 339,895 20 2006-2007 337,982 21 2007-2008 333,587 10) RESEARCH CENTER FOR AUDITORY AND VESTIBULAR STUDIES

National Institute on Deafness and Other Communication Disorders Grant 5P30 DC004665 – Principal Investigator

1 2007-2008 $545,699 Total: $2,593,224 2 2008-2009 531,421 3 2009-2010 756,138 4 2010-2011 759,966* 11) CELLULAR AND MOLECULAR BIOLOGY OF CHOLESTEATOMA National Institute on Deafness and Other Communication Disorders Grant #2 R01 DC00263-22A2 - Principal Investigator 22 2010-2011 $380,000 Total: $1,900,000 23 2011-2012 380,000 24 2012-2013 380,000 25 2013-2014 380,000 26 2014-2015 380,000 Non-Government Private Foundation Grants 1) SUSCEPTIBILITY OF THE LABORATORY MOUSE TO AUDIOGENIC SEIZURES AFTER SOUND DEPRIVATION Deafness Research Foundation - Co-Investigator (Principal Investigator: Kenneth R. Henry, Ph.D.) 01 1979 $10,000 Total: $30,000 02 1980 10,000 03 1981 10,000 2) OTOSCLEROSIS IN THE LP/J INBRED MOUSE: AN EXPERIMENTAL MODEL American Otological Society - Principal Investigator 01 1983-1984 $16,842 Total: $40,543 02 1984-1985 23,701 3) OTOSCLEROTIC LESIONS IN THE MOUSE: AN EXPERIMENTAL MODEL American Otological Society - Principal Investigator

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1985-1986 Total: $20,834 4) STUDIES OF THE PATHOGENESIS OF SPONTANEOUS CHOLESTEATOMA IN GERBILS Deafness Research Foundation - Principal Investigator (Co-investigator: Steven P. Tinling) 1986 Total: $12,500 5) THE ROLE OF ARACHIDONIC ACID METABOLITES ON MIDDLE EAR BONE REMODELING American Otological Society - Principal Investigator 1988-1989 Total: $25,000 6) IN VIVO INHIBITION OF BONE RESORPTION IN THE MIDDLE EAR Deafness Research Foundation Otological Research Fellowship Sponsor: Richard A. Chole, M.D., Ph.D. Recipient: Kristi Adachi, PGIII 1988-1989 Total: $13,500 7) THE ROLE OF ARACHIDONIC ACID METABOLITES ON MIDDLE EAR BONE REMODELING American Otological Society - Principal Investigator 1989-1990 Total: $25,000 8) PRESSURE INDUCED MIDDLE EAR BONE RESORPTION IN THE SYMPATHECTOMIZED

GERBIL. American Otological Society Research Fellowship Sponsor: Richard A. Chole, M.D., Ph.D. Recipient: Bret E. Sherman, MSIII 1990-91 Total: $19,768 9) THE INFLUENCE OF NEUROEFFECTORS AND BONE INNERVATION ON OSTEOCLAST

RECRUITMENT AND ACTIVATION. American Otological Society Research Fellowship Sponsor: Richard A. Chole, M.D., Ph.D. Recipient: Bret E. Sherman, MSIII 1991-92 Total: $23,986 University Grants 1) STUDIES ON THE ROLE OF VITAMIN A IN THE AUDITORY SYSTEM University of California Biomedical Research Grant - Principal Investigator 1977-1978 Total: $1,800

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2) Morton Levitt Student Research Scholarship Awarded to Henry Cramer, Medical Student Faculty Sponsor: R. Chole 1983-1984 Total: $800 3) Morton Levitt Student Research Scholarship Awarded to Henry Milczuk, Medical Student Faculty Sponsor: R. Chole 1984-1985 Total: $800 4) Morton Levitt Student Research Scholarship Awarded to Bret Sherman, Medical Student Faculty Sponsor: R. Chole 1989-90 Total: $800 STUDENT AND RESIDENT RESEARCH SPONSOR Awards KRISTI ADACHI, M.D. Loren D. Carlson Award, 1989-90 JUDY BLAZUN, M.D. Sixth Annual Bay Area Residents' Research Symposium (BARRS) Third Place Award, 1990 HILARY BRODIE, M.D. University of California, Davis Medical Scholar, 1985-1986 HENRY CRAMER, M.D. Morton Levitt Student Research Scholarship Award MICHAEL JUNGKEIT, M.D. Lillian Rapp Memorial Foundation Grant, 1988-89 JOHN MACRI, M.D. American Academy of Otolaryngology Research Forum Third Place Award for Basic Research - 1983 "Bone erosion in experimental cholesteatoma - The effects of implanted barriers" HENRY MILCZUK, M.D. Morton Levitt Student Research Scholarship Award ANN RICHARDSON, M.D. American Academy of Otolaryngology Research Forum First Place Award for Basic Science Research - 1993 "Risedronate inhibition of bone resorption in neonatal mouse calvaria"

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BRET SHERMAN, MS III Rapp Memorial Foundation Research Scholarship, 1989-90 BRET SHERMAN, M.D. American Otological Society Research Fund Fellowship, 1990-91 and 1991-92 "Pressure induced middle ear bone resorption in the sympathectomized gerbil" "The influence of neuroeffectors and bone innervation on osteoclast recruitment and activation" BRET SHERMAN, M.D. National Student Research Forum First Place Award for Basic Science Research - 1995 BRET SHERMAN, M.D. American Academy of Otolaryngology First Place Award for Research - Medical Student - 1995 “A mechanism for sympathectomy-induced bone resorption in the middle ear” BRET SHERMAN, M.D. First Place Award for Medical Student in Research American Medical Association - 1995 “A mechanism of sympathectomy-induced bone resorption” DAVID WOLFMAN, M.D. American Academy of Otolaryngology Research Forum First Place Award for Basic Research - 1985 NWANMEGHA YOUNG, MS IV Merck/AAMP Minority Medical Student Summer Research Fellowship – 1997 BRET SHERMAN, M.D. First Place Resident Basic Science Award – 1999

“Effects of leukotriene and cyclo-oxygenase inhibition on adaptive bone remodeling in the middle ear”

ERIC WANG, M.D. Michael Paparella Resident Research Award, Washington University – 2005 LEI ZHUANG, M.D. Michael Paparella Resident Research Award, Washington University – 2005 ROBERT NASON, M.D. Michael Paparella Resident Research Award, Washington University – 2007 LEI ZHUANG, M.D. Michael Paparella Resident Research Award, Washington University – 2007 Katherine Kao, M.D. 2012-2014 Ph.D. Graduate Advisor - Comparative Pathology Graduate Group HILARY BRODIE, M.D.

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Project title: "Studies of the role of autoimmunity in otosclerosis and otosclerosis-like lesions in LP/J mice" Ph.D. completed December 1990 Current Position: Chair, Department of Otolaryngology, Univeristy of California-Davis BRIAN T. FADDIS, M.S.

Project title: "Mechanism of spongiform encephalopathy in the auditory brainstem of the Mongolian gerbil"

Ph.D. completed June 1994 Current Position: Research Assistant Professor, Department of Otolaryngology, Washignton University School of Medicine BRET SHERMAN, MS III

Project title: “The in vitro effects of neuropeptides VIP, CGRP, SP and NPY on intramembraneous bone resorption.”

M.D., Ph.D. completed June 1995 STEVEN P. TINLING, B.A., M.A. Project title: "The role of the basal lamina in the pathogenesis of middle ear cholesteatoma" Ph.D. completed October 2004

Current Position: Director of Research, Department of Otolaryngology, University of California-Davis

JAE JUNG, Ph.D. Project title: “The role of nitric oxide in cholesteatoma induced bone resorption” Ph.D. completed February 2003, Washington University Current Position: Dermatology Resident, Washington University School of Medicine 2011 PASCALE GUITON

Project title: “Investigation of the major inflammatory and immunological pathways activated following catheterization and enterococcal infections” Department of Molecular Microbiology Graduate Student, Washington University School of Medicine Thesis Committee Member 2010-2011

M.S. Graduate Advisor - Comparative Pathology Graduate Group JEREMY GOODWIN, B.A. Thesis title: "Morphometric studies of spiral ganglion cell loss in gerbils with cholesteatomas" Completed 1985 Resident Research Projects

R. STAN BAKER, M.D. - " A randomized clinical trial of topical gentamicin after tympanostomy tube placement" (Arch Otolaryngol 1988; 114: 755-757) HILARY BRODIE, M.D. - "The possible role of immunologic injury in the dysplastic bony lesion in LP/J mice" (Am J Otolaryngol 1987; 8:342-350)

HILARY BRODIE, M.D. - "The effect of sodium fluoride on the dysplastic bony lesions and auditory brainstem responses in LP/J mice" (Presented at 1987 Resident Research Forum, American Academy of Otolaryngology)

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HILARY BRODIE, M.D. - "Recurrent pneumosialadenitis: A case presentation and new surgical intervention" (Otolaryngol-Head Neck Surg 1988; 98(4): 350-353)

HILARY BRODIE, M.D. - "Otosclerosis-like lesions in LP/J mice" (Comp Path Bull, May, 1988) MARTHA CORCORAN, M.D. - "Plexiform Neurofibroma" (In preparation, September, 1991).

BRUCE FERNANDEZ, M.D. - "Epithelial membrane antigen expression in benign and malignant squamous epithelium of the head and neck" (Otolaryngol Head Neck Surg 1987; 97(3): 288-293 (R. A. Chole, Advisor). BRIAN ORISEK, M.D. - "Pressures exerted by experimental cholesteatomas" (Arch Otolaryngol 1987; 113: 386-391).

DAVID WOLFMAN, M.D. - "Osteoclast stimulation by positive middle-ear air pressure" (Arch Otolaryngol 1986; 112(10): 1037-1042).

DAVID WOLFMAN, M.D. - "Experimental retraction pocket cholesteatomas" (Ann Otol Rhinol Laryngol 1986; 95(6): 639-644).

JAMES YEE, M.D. - "Antibiotic prophylaxis for facial fractures: A prospective, randomized clinical trial" (Arch Otolaryngol 1987; 105: 1055-1057).

CAROL MacARTHUR, M.D. and KATHERINE KENDALL, M.D. - "Late recurrence of cystic hygromas after conservative management," Abstract (Otolaryngol-Head Neck Surg 1989; 101:239). MARTHA CORCORAN, M.D. - "Diffuse neurofibroma of the head and neck," (Otolaryngol - Head Neck Surg 1991; 105:292).

ANN RICHARDSON, M.D. - "Congenital Lip Pits," (Otolaryngol - Head Neck Surg 1991; 105:306).

PAMELA BOHRER, M.D. and JUDY BLAZUN, M.D. - "Intracanalicular meningioma," submitted for 1992 AAO-HNS Research Forum. SKARADA, DOUGLAS, M.D. - R.A. Chole and Skarada, D.J. Middle Ear Reconstructive Techniques.” Otolaryngologic Clinics of North America, December, 1999. YOUNG, MEGHA, M.D. – “Cytokine-mediated Bone Resorption is Cytochrome P-450 Dependent,” Otolaryngology-Head and Neck Surgery. Vol.121(6):708-712, December. 1999 “Vitamin D stimulates osteoclast activation and recruitment in the RANKL-osteoclast culture,” January 2002 RAVINDHRA ELLURU, M.D., Ph.D.- 2001 – Expression of cytokine signals in bone remodeling, involving immunohistochemistry and insitu hybridization. ABRAHAM JACOB, M.D. – 2000-2002 “Chronic Bacterial Rhinosinusitis: Description of a Mouse Model,” Archives of Otolaryngology-Head and Neck Surgery, 127:657-664, June, 2001 and “MeroGel Hyaluronic Acid Sinonasal Implants: Osteogenic Implications,” Laryngoscope, 111: November, 2001. NWANMEGHA YOUNG, M.D. – 1999-2006 – Cytochrome P450 mediation of bone resorption ERIC WANG, M.D. – Investigation of Bacterial Biofilms in Cholesteatomas, 2001-2002 – 2003-2004. “Otopathogenic Pseudomonas aeruginosa (OPPA) adhere to keratinocytes and express

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quorumn sensing genes,” June 2003. “Phenotype of otopathogenic P. aeruginosa implicates cholesteatoma as a biofilm disease,” September 2003 Wang, EW, et al. Otopathogenic Pseudomonas aeruginosa are competent biofilm formers. Arch Otolaryngol, 131 (11): 983-9, November, 2005 Adherence of Otopathogenic Pseudomonas aeruginosa to human keratinocytes, 2005. Grants in preparation: Role of Supplemental Perioperative Oxygen and Pharyngocutaneous Fistula Formation After Surgical Resection of Advanced Head and Neck Squamous Cell Carcinoma. LEI ZHUANG, M.D. – “Effect of Pseudomonas aeruginosa virulence factors on osteoclastogenesis in vitro,” 2003-2004

ROBERT NASON, M.D. – “Invasion of human keratinocytes by otopathogenic Pseudomonas aeruginosa,” 2003-2004

OSARENOMA OLOMU, M.D. – 2006-2007 – “Otopathogenic Pseudomonas aeruginosa biofilm biology and its effects of chronic otitis media”

WEE TIN (KATHERINE) KAO, M.D. – 2012-2014 – “The role of biofilms in the etiology of sialolith formation” and "Interstrain differences in P. aeruginosa biofilm growth on charged surfaces” Student Research Projects

KRISTI ADACHI (intern) - "Indomethacin inhibition of osteoclastic bone resorption in vivo. Submitted to Ann Otol Rhinol Laryngo, 1990.

KRISTI ADACHI - "Inhibition of osteoclast recruitment at a local site by 1-Hydroxyethylinediene-1,1 bisphosphonate (HEBP)," Ann Otol Rhinol Laryngol 1990; 99(9): 738-741 (Sept). KRISTI ADACHI - "Management of tracheal lesions in Hurler syndrome," Arch Otolaryngol 1990; 116:1205-1207. DARYL CHAN - "Rapid induction of localized bone resorption in the auditory bulla of the Mongolian gerbil, Meriones unguiculatus, by increased air pressure," Calc Tiss Intl 1989; 45(5): 318-323.

KATHERINE CHOLE - “Inhibition of nitric oxide blocks adaptive bone modeling.”

GLENN COOK, M.D., Ph.D. - "The Rinne test for conductive deafness: A critical reappraisal," Arch of Otolaryngol 1988; 114:399-403.

JAE JUNG, B.S. - “Osteoclast activation in the in vitro mouse calvarial bone resorption model by IL-1 is inhibite d by IL-1ra in a dose dependent manner.” MICHAEL JUNGKEIT, M. D. - "Effects of ibuprofen on pressure induced osteoclastic bone resorption in the Mongolian gerbil, Meriones unguiculatus" (in preparation). MICHAEL JUNGKEIT, M.D. - "Ibuprofen inhibits localized bone resorption in the middle ear," Calc Tiss Intl 1991; 48:266-271.

LAURA KELLY - “Development of a serum free media method for the in vitro mouse calvarial bone resorption model.” KEVIN KODAMA - "Comparative histology of the tympanic membrane and its relationship to cholesteatoma," Ann Otol Rhinol Laryngol 1989; 98(10):761-766.

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ERIN LEVERENTZ - “Inhibition of nitric oxide blocks adaptive bone modeling.”

HENRY MILCZUK - "In vitro effects of osteoclast activating factors from cholesteatoma on cultured gerbil calvaria."

BRET SHERMAN, M.D., Ph.D. - "Effects of neuropeptides on bone remodeling."

DAMON SILVERMAN - “Development of an assessment method for in vitro osteoclast activation using standardized hydroxyapatite coated glass disks.”

NWANMEGHA YOUNG, MS IV - “The effect of cytochrome P450 inhibition on nitric acid production and bone modeling in activated mouse calvarial culture.”

SHERI NISHOMOTO – “Activation of calpain in the cochlea following noise exposure,” 1998-

1999. AARON LIN, M.D. – ”Characterizing the role of interleukin-1 in the stimulation of osteoclasts

formation and activation,” 2000-2001. MELONIE NANCE, M.D. Leon O. Jacobson Prize at 56th Annual Senior Scientific Session by a non-PhD student 2002 Research Fellowship – 2001

MELONIE NANCE, M.D. – “Cellular and molecular biology of cholesteatoma” – studying the role of interleukin 1B, an interleukin receptor antagonist in inflammatory bone loss in osteoclasts activation,” 2001-2002. LISETTE RAMOS, M.D. – “Cellular and molecular biology of cholesteatoma.” Summer 2003, Fall 2004.

MEGAN LEVERENTZ, D.V.M. 2003 DANIEL RUNCO, B.S.

“Otopathogenic Pseudomonas aeruginosa biofilm biology and its effects of potential modifiers of chronic otitis media” 2006 ROBERT WONG, M.D. “LPS pathogenic strains of Pseudomonas aeruginosa” 2007 DONG (JOSEPH) LEE, M.D. “Mechanisms of bone erosion in cholesteatoma in both a mouse model and gerbils” “Radiographic and micro-computer tomographic imaging of lipopolysaccharide-mediated bone resorption” 2007

BEN JACOBS – 2005 BRIAN KULBERSH, MD - 2005 JEFFREY YU, MD – “Pseudomonas LPS signaling through the toll-like 4 reception in osteoclast precursors “ - June 20, 2006-June 20, 2007

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GABRIELA AGOSTINI PORRAS, MD – “Pseudomonas aeruginosa biofilms in flow chambers are inhibited by gentian violet and ferrous ammonium citrate” – 2007 JENNIFER PICK, MD “Pseudomonas biofilm development and inhibitors - 2010-2011

JOSEPH ZENGA – 2011-2012 – “

Fellowship Research Projects

MOO-JIN CHOO, M.D., Ph.D. - “Cytochrome P450 inhibition blocks bone resorption in vitro and in vivo.”

HYUNG-JONG KIM, M.D., Ph.D. - “Gerbilline models of aural cholesteatoma.” and “Changes in cytokeratin expression during experimental cholesteatoma formation.” HOLGER SUDHOFF, MD – “Zoledronic acid inhibits osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis. Annals of Otology, Rhinology & Laryngology, 112:9, 780-786, September, 2003.

SOON-JOON SOHN, M.D. BIBLIOGRAPHY: LIST OF PUBLICATIONS 1. 1975 Quick, CA and Chole RA. Deafness and renal failure due to potassium bromate

poisoning. Archives of Otolaryngology 102(8): 494-495, August. 2. 1976 Chole, RA and Quick, CA. Temporal bone histopathology in experimental

hypovitaminosis A. The Laryngoscope 86(3): 445-453, March. 3. 1978 Chole, RA and Quick, CA. Estimate of vitamin A in the guinea pig cochlea. Annals of

Otology, Rhinology and Laryngology 87(3): 380-382, May-June. 4. 1978 Chole,RA and Quick, CA. Experimental temporal bone histopathology in rats deprived of

dietary retinol and maintained with supplemental retinoic acid. Journal of Nutrition 108(6): 1008-1016, June.

5. 1978 Chole, RA. Sphenoid sinus mucocele simulating a malignancy. Annals of Otology,

Rhinology and Laryngology 87(4): 586-587, July-August. 6. 1978 Chole, RA. Experimental studies on the role of vitamin A in the inner ear.

Otolaryngology 86: 595-620, July-August. 7. 1978 Chole, RA. Adenomyeloblastoma (Adenomatoid odontogenic tumor). Archives of

Otolaryngology 104: 420-422, July.

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8. 1979 Chole, RA. Endoscopic photography of the tympanic membrane. Transactions of the Pacific Coast Oto-Ophthalmological Society 60: 45-47, January.

9. 1979 Shea, DA, Chole, RA. and Paparella, PP. The endolymphatic sac: Anatomical

considerations. Laryngoscope 89: 88-93, January. 10. 1979 Henry, KR and Chole RA. Cochlear electrical activity in C57BL/6 laboratory mouse

volume-conducted vertex and round window responses. Acta Otolaryngologica 87(1): 61-68, January-February.

11. 1979 Chole, RA. Squamous metaplasia of the middle ear mucosa during vitamin A

deprivation. Otolaryngology-Head and Neck Surgery 87: 837-844, November. 12. 1979 Chole, RA. and Domb, GH. Differential diagnosis of superficial ulcerations of the oral

mucosa. Otolaryngology-Head and Neck Surgery 87: 734-740, November-December. 13. 1980 Chole, RA, Bass, LJ, Daniels, TE, Donald, PJ. Problems in diagnosis and treatment of

oral disease. Transactions of the Pacific Coast Oto-Ophthalmological Society 60: 49-64, January.

14. 1980 Bernstein, L, Donald, and Chole, RA. Prophylactic radical neck dissection in melanoma

of the face and scalp, p. 239-244. In:.Snow B, Jr., ed. Controversies in Otolaryngology, W. B. Saunders Co., Philadelphia.

15. 1980 Chole, RA. Photography of the tympanic membrane: A new method. Archives of

Otolaryngology 106: 230-231, April.36. 16. 1980 Domb, GH. and Chole, RA. The diagnosis and treatment of scrofula (mycobacterial

cervical lymphadenitis). Otolaryngology-Head and Neck Surgery 88: 338-341, July-August.

17. 1980 Henry, KR. and Chole, RA. Genotypic differences in behavioral, physiological and

anatomical expressions of age-related hearing loss in the laboratory mouse. Audiology 19:369-383, September.

18. 1980 Domb, GH. and Chole, RA. Anatomical studies of the posterior petrous apex with regard

to hearing preservation in acoustic neuroma removal. Laryngoscope 90(11): 1769-1776, November.

19. 1980 Henry, KR., McGinn, MD and Chole, RA. Age-related auditory loss in the Mongolian

gerbil. Archives of Otolaryngology 228: 233-238. 20. 1980 De Clercq, LD. and Chole, RA. Retropharyngeal abscess in the adult. Otolaryngology -

Head and Neck Surgery 88: 684-689, November-December. 21. 1980 Chole, RA. Autoradiographic localization of vitamin A in the stria vascularis of the rat cochlea. Archives of Otolaryngology 106: 741-743, December. 22. 1980 Domb, GA. and Chole, RA. Oral pyrosis. Transactions of the Pacific Coast Oto-

Ophthalmological Society Annual Meeting 61: 137-151. 23. 1981 Henry, KR., Chole, RA., McGinn, MD and Frush, DP. Increased ototoxicity in both young

and old mice. Archives of Otolaryngology 107: 92-95, February.

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24. 1981 Chole, RA., Henry, KR and McGinn, MD. Cholesteatoma: Spontaneous occurrence in the Mongolian gerbil Meriones unguiculatus. American Journal of Otology 2(3): 204-210, January.

25. 1981 Domb, GA and Chole, RA. The burning mouth and tongue. Ear, Nose and Throat

Journal 60(7): 310-314, July. (Reprinted in December, 1982 issue of Osteopathic Annals, Insight Publishing Company, New York.

26. 1981 Henry, KR, McGinn, MD, Berard, DR and Chole, RA. Effects of neonatal thyroxine,

genotype and noise on the ear and audiogenic seizures. Journal of Comparative Physiological Psychology 95(3): 418-424.

27. 1981 Chole, RA and Charpied, GL. Preparation of small temporal bones for high-resolution

light microscopy. Archives of Otolaryngology 107: 610-612, October. 28. 1982 McGinn, MD., Chole, RA and Henry, KR. Cholesteatoma: Experimental induction in the

Mongolian gerbil, Meriones unguiculatus. Acta Otolaryngologica 93: 61-67. 29. 1982 Chole, R A and Frush, DP. Quantitative studies of eustachian tube epithelium during

vitamin A deficiency and reversal, p. 321-327. In: Sade J, ed., Cholesteatoma and Mastoid Surgery, Proceedings, 2nd International Conference. Tel Aviv, Israel, 22-27 March, 1981, Kugler Publications, Amsterdam.

30. 1982 Chole, RA, Henry, KR and McGinn, MD. The gerbilline cholesteatoma: An experimental

model, p. 291-296. In: Sade J, ed. Cholesteatoma and Mastoid Surgery, Proceedings, 2nd International Conference. Tel Aviv, Israel, Kugler Publications, Amsterdam, March.

31. 1982 Chole, RA. Ossicular replacement with self-stabilizing presculptured homologous

cartilage. Archives of Otolaryngology 108: 560-562, September. 32. 1982 Chole, RA. A Colour Atlas of Ear Disease, 70 pages, Wolfe Medical Publishers, London,

April. 33. 1982 Chole, RA. A Color Atlas of Ear Disease, 70 pages, Appleton-Century-Croft,

Connecticut, June. 34. 1982 Chole, RA and Henry, KR. K. R. Henry. Disparity in the cytocochleogram and the

electrocochleogram in aging LP/J and A/J inbred mice. Audiology 22: 384-392. 35. 1983 Henry, KR, Chole, RA and McGinn, MD. Age-related increase of spontaneous aural

cholesteatoma in the Mongolian gerbil. Archives of Otolaryngology 109(1): 19-21, January.

36. 1983 Henry, KR, Guess, MB and Chole, RA.. Hyperthermia increases aminoglycoside

ototoxicity. Acta Otolaryngologica 95: 323-327. 37. 1983 Chole, RA. Meatoplasty using inferiorly based island pedicle flap for congenital aural

atresia: How I do it. Laryngoscope 93(7): 954-955, July. 38. 1983 Chole, RA. and Henry, KR. Otosclerotic lesions in the inbred LP/J mouse. Science 221:

881-882, August. 39. 1983 Chole, RA and Charpied, GL. A histomorphometric study of the effect of chronic vitamin

A deficiency on the circumvallate papilla of the rat. Otolaryngology-Head and Neck Surgery 91(5): 470-481, October.

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40. 1983 Chole, RA and Donald, PJ. Petrous apicitis I: Clinical considerations. Annals of Otology, Rhinology and Laryngology 92(6): 544-551, November-December.

41. 1984 Chole, RA. The cellular and subcellular events of bone resorption in human and

experimental cholesteatoma: The role of osteoclasts. Laryngoscope 94(1): 76-95, January.

42. 1984 McGinn, MD, Chole, RA. and Henry, KR. Cholesteatoma induction: Consequences of

external auditory canal ligation in gerbils, cats, hamsters, guinea pigs, mice and rats. Acta Otolaryngologica (Stockholm) 97: 297-304.

43. 1984 Donald, PJ and Chole, RA. Superior based trapezius flap. Laryngoscope 94(7): 969-

973, July. 44. 1984 Donald, PJ and Chole, RA. The transcervical transmastoid approach to lesions of the

jugular bulb. Archives of Otolaryngology 110: 309-314, May. 45. 1984 Orisek, BS. and Chole, RA. Pressure measurements of induced gerbilline

cholesteatomas: A preliminary report. Transactions of the Pacific Coast Oto-Ophthalmological Society 65:183-193.

46. 1984 Henry, KR. and Chole, RA. Hypothermia protects the cochlea from noise damage.

Hearing Research 16: 225-230. 47. 1985 Macri, JR. and Chole, RA. Bone erosion in experimental cholesteatoma - the effects of

implanted barriers. (1983 Third-Place Resident Research Award: Basic Category, AAO-HNS and ARO). Otolaryngology-Head and Neck Surgery 93(1): 3-17, February.

48. 1985 Chole, RA and Tinling, SP. Basal lamina breaks in the histogenesis of cholesteatoma.

The Laryngoscope 95(3): 270-275, March. 49. 1985 Chole, RA., McGinn, MD and Tinling, SP. Pressure-induced bone resorption in the

middle ear. Annals of Otology, Rhinology and Laryngology 94(2): 165-170, March-April. 50. 1985 Chole, RA. Petrous apicitis II: Surgical anatomy. Annals of Otology, Rhinology and

Laryngology 94: 251-257, May-June. 51. 1985 Chole, RA and Henry, KR. Ossicular and otic capsular lesions in the LP/J mouse.

Annals of Otology, Rhinology and Laryngology 94: 366-372, July-August. 52. 1985 Chole, RA and Chiu, M. Ultrastructure of the middle ear mucosa of the Mongolian gerbil,

Meriones unguiculatus. Acta Otolaryngologica 100: 273-288, October. 53. 1985 Ferrell, F, Tsuetaki, T and Chole, RA. Myelination in the chorda tympani of the postnatal

rat: A quantitative electron microscope study. Acta Anatomica 123: 224-229, November. 54. 1985 Cramer, H and Chole, RA. The dynamics of otosclerosis-like lesions in LP/J mice.

Annals of Otology, Rhinology and Laryngology 95(2): 169-172, March-April. 55. 1985 Chole, RA. The use of pre-sculpted homologous cartilage transplants in ossicular

replacement. New Dimensions in Otorhinolaryngology - Head and Neck Surgery, vol. 2, Proceedings of the XIIIth World Congress, E. Myers, Ed., Elsevier Science Publishers B.V., New York, pp. 432-433.

56. 1985 Chole, RA and Tinling, SP. Autoradiographic studies of mineral transport from regions of

bone resorption in experimental cholesteatoma. New Dimensions in Otorhinolaryngology

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- Head and Neck Surgery, vol. 2, Proceedings of the XIIIth World Congress, E. Myers, Ed., Elsevier Science Publishers B.V., New York, pp. 9-10.

57. 1985 Fulghum, RS. and Chole, RA. Bacterial flora in spontaneously occurring aural

cholesteatomas in Mongolian gerbils. Infection and Immunity 50(3): 678-681, December. 58. 1986 Chole, RA. and McGinn, MD. Aural cholesteatoma in the Mongolian gerbil. Comparative

Pathology Bulletin, Animal Model Series, Armed Forces Institute of Pathology 18(2): 2,4. 59. 1986 McGinn, MD., Chole, RA and Tinling, S. Bone resorption induced by middle ear implants.

Archives of Otolaryngology-Head and Neck Surgery 112: 635-641, June. 60. 1986 Chole, RA. Surgery for petrous apicitis. In: Wiet R, Causse B, eds. Complications in

Otolaryngology-Head and Neck Surgery. B.C. Decker, Inc., pp. 111-115, June. 61. 1986 Chole, RA. Acute and chronic infection of the temporal bone including otitis media with

effusion. In: Cummings, Frederickson, Harker, Krause and Schuller (eds). Otolaryngology-Head and Neck Surgery.

62. 1986 Wolfman, DE and Chole, RA. Osteoclast stimulation by positive middle-ear air pressure.

Archives of Otolaryngology-Head and Neck Surgery, 112: 1037-1042, October. 63. 1986 Wolfman, DE. and Chole, RA. Experimental retraction pocket cholesteatomas. Annals of

Otology, Rhinology and Laryngology 95(6): 639-644, November-December. 64. 1987 Chole, RA. Use of presculpted, banked cartilage transplants in ossicular reconstruction.

Archives of Otolaryngology 113: 145-148, February. 65. 1987 Orisek, BS and Chole, RA. Pressures exerted by experimental cholesteatomas.

Archives of Otolaryngology 113: 386-391, April. 66. 1987 Fulghum, RS., Chole, RA, Brinn, JE and Branigan, AE. Mongolian gerbil tympanic

membrane: Normal and with induced otitis media. Archives of Otolaryngology 113: 521-525, May.

67. 1987 Henry, KR. and Chole, RA. Genetic and functional analysis of the otosclerosis-like

condition of the LP/J mouse. Audiology 26: 44-55. 68. 1987 Chole, RA. and Yee, J. Antibiotic prophylaxis for facial fractures: A prospective,

randomized clinical trial. Archives of Otolaryngology 113: 1055-1057, October. 69. 1987 Chole, R A and Tinling, SP. Fine morphology of bony dysplasia of the murine ear:

Comparisons with otosclerosis. American Journal of Otolaryngology 8: 325-331. 70. 1987 Brodie, HA and Chole, RA. The possible role of immunologic injury in the dysplastic bony

lesion in LP/J mice. American Journal of Otolaryngology 8: 342-350. 71. 1988 Chole, RA. and Chiu, M. Cochlear hair cell loss in ears with cholesteatomas: Scanning

electron microscopy study. Annals of Otology, Rhinology and Laryngology 97(1): 78-82, January-February.

72. 1988 Brodie, HA and Chole, RA. Recurrent pneumosialadenitis: A case presentation and new

surgical intervention. Otolaryngology-Head and Neck Surgery 98(4): 350-353, April. 73. 1988 Chole, RA and Cook, GB. The Rinne test for conductive deafness: A critical reappraisal.

Archives of Otolaryngology-Head & Neck Surgery 114: 399-403, April.

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74. 1988 Brodie, HA and Chole, RA. Human Disease: Otosclerosis/Animal Model: Otosclerosis-

like lesions in LP/J mice. Comparative Pathology Bulletin 20(2):2-3, May. 75. 1988 Baker, RS and Chole, RA. A randomized clinical trial of topical gentamicin after

tympanostomy tubes. Archives of Otolaryngology-Head and Neck Surgery 114: 755-757, July.

76. 1988 Chole, RA. Childhood hearing loss. In: Hudson W., Reinhart M. A., Rose S. D., Stewart

G.. K., eds. Clinical Preventive Medicine: Health Promotion and Disease Prevention, W. Hudson, M. A. Reinhart, S. D. Rose and G. K. Stewart, Eds. Little, Brown and Co., Boston, Chapter 43.

77. 1988 Chole, RA. Osteoclasts in chronic otitis media, cholesteatoma, and otosclerosis. Annals

of Otology, Rhinology and Laryngology 97: 661-666, November-December. 78. 1989 Chole, RA. Magnification changes produced by coverslip compensation rings on

microscope objectives. Letter to the Editor, Journal of Microscopy 153(1): 119, January. 79. 1989 Lee, BC. Black, PML, Lamb, RB, Arnold JP, Seibert, A, Chole, RA and Bacon, GV. CT

evaluation of the temporal bone ossicles by using oblique reformations: A technical note. American Journal of Neuroradiology 10(2): 431-433, March-April.

80. 1989 Chole, RA and Chiu, M. Cochlear hair cell stereocilia loss in LP/J mice with bone

dysplasia of the middle ear. Annals of Otology, Rhinology and Laryngology 98(6): 461-465, June.

81. 1989 McKennan, KX and Chole, RA. Post-traumatic cholesteatoma. Laryngoscope 99(8):

779-782, August. 82. 1989 Chole, RA and Kodama, K. Comparative histology of the tympanic membrane and its

relationship to cholesteatoma. Annals of Otology, Rhinology and Laryngology 98(10):761-766, October.

83. 1989 Chole, RA and Chan, DE. Rapid induction of localized bone resorption in the auditory

bulla of the Mongolian gerbil, Meriones unguiculatus, by increased air pressure. Calcified Tissue International 45(5): 318-323, November.

84. 1989 Chole, RA. Mechanisms of osteoclast activation in cholesteatoma. In: Tos M, Thomsen

J, Peiterson E., eds. Cholesteatoma and Mastoid Surgery. Amsterdam, Kugler and Ghedini, 1988:185-190.

85. 1990 Serdahl, CL, Berris, CE and Chole, RA. Nasolacrimal duct obstruction after endoscopic

sinus surgery. Archives of Ophthalmology 108:391-392, March. 86. 1990 Adachi, K and Chole, RA. Inhibition of osteoclast recruitment at a local site by 1- Hydroxyethylinediene-1,1 bisphosphonate (HEBP). Annals of Otology, Rhinology and

Laryngology 1990; 99(9): 738-741, September. 87. 1990 Chole, RA and Adachi, K. Management of tracheal lesions in Hurler syndrome. Archives

of Otolaryngology-Head and Neck Surgery 116:1205-1207, October. 88. 1991 Chole, RA and McGinn, MD. Immunoglobulin E and circulating immune complexes in

endolymphatic hydrops, [letter] Annals of Otology, Rhinology and Laryngology 100(5 Pt 1):431-432, May.

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89. 1991 Jungkeit, MC and Chole, RA. Ibuprofen inhibits localized bone resorption in the middle ear. Calcified Tissue International 48:267-271, April.

90. 1991 Adachi, K., Chole, RA and Yee, J. Indomethacin inhibition of middle ear bone resorption.

Archives of Otolaryngology-Head and Neck Surgery 117:267-269, March. 91. 1991 McGinn, MD and Chole, RA. Cochlear bone erosion: Effects on cochlear hair cells. A

scanning electron microscopy study. Annals of Otology, Rhinology and Laryngology 100(12):1015-1019, December.

92. 1992 McKennan, KX and Chole, RA. Traumatic external auditory canal atresia. American

Journal of Otology 13(1): 80-81, January. 93. 1992 McKennan, KX and Chole, RA. Facial paralysis in temporal bone trauma. American

Journal of Otology 13(2):167-172, March. 94. 1992 Chole, RA and Parker, WS. Tinnitus and vertigo in patients with temporo-mandibular

disorders. Archives of Otolaryngology-Head and Neck Surgery 118: 817-821, August. 95. 1992 Brodie, HA, White, JG and Chole, RA. Macrothrombocytopenia and progressive

deafness: A new genetic syndrome. American Journal of Otology 13(6): 507-511, November.

96. 1992 Chole, RA. (Panelist and Coauthor). National Strategic Research Plan for Hearing and

Hearing Impairment and Voice and Voice Disorders, National Institute on Deafness and Other Communication Disorders, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, NIH Publication No. 93-3443.

97. 1993 Chole, RA. Chronic Otitis Media, Mastoiditis, and Petrositis. In: Cummings,

Fredrickson, Harker, Krause, Schulle, eds. Otolaryngology-Head and Neck Surgery, Second Edition. St. Louis, C.V. Mosby, Vol. 4, Chapter 157, pp. 2823-2839.

98. 1993 Chole, RA and Tinling, SP. Inflammatory disease of the middle ear and their sequelae.

Chapter in The Pathology of the Ear, ed. by I. Friedmann and W. Arnold, Churchill Livingstone, United Kingdom.

99. 1993 Chole, RA and Brodie, HA. Surgery of the mastoid and petrosa. In: Bailey B J, ed.

Head and Neck Surgery - Otolaryngology Philadelphia, J.B. Lippincott Company, Chapter 125.

100. 1993 Chole, RA. Cholesteatoma and Mastoid Surgery. Oto-Rhino-Laryngology Tokyo 36:86-

90. 101. 1993 Chole, RA. Aural cholesteatoma in the Mongolian gerbil. The Registry of Comparative

Pathology, 19 fascicle to the Handbook: Animal Models of Human Disease, Supplemental Update, Model 331.

102. 1993 Chole, RA and Tinling, SP. Incomplete coverage of mammalian bone matrix by lining

cells. Annals of Otology, Rhinology and Laryngology 102:543-550. 103. 1993 Chole, RA. Differential osteoclast activation in endochondral and intramembranous

bone. Annals of Otology, Rhinology and Laryngology 102(8):616-619, August. 104. 1993 Chole, RA. (Panelist and Coauthor). National Institutes of Health Consensus Statement

on Early Identification of Hearing Impairment in Infants and Young Children, Vol. 11, No. 1, March.

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105. 1993 Chole, RA. Chronic otitis and cholesteatoma. Current Opinion in Otolaryngology & Head

and Neck Surgery 1:19-23. 106. 1993 Chole, RA. (Panelist and Coauthor). National Institutes of Health Consensus

Development Conference Statement on Early Identification of Hearing Impairment in Infants and Young Children, March 1-3, 1993. Journal of Medical Association, June.

107. 1993 Baker, RS and Chole, RA. Ventilation tubes and prophylactic antibiotic eardrops [letter].

Otolaryngology - Head and Neck Surgery 109(3 Pt 1):559-560, September. 108. 1993 Brodie, HA, Change, PS and Chole, RA. Dexamethasone inhibition of development of

dysplastic bony lesions in LP/J mice. Annals of Otology, Rhinology and Laryngology 102(10):814-817, October.

109. 1993 Richardson, A, Tinling, SP and Chole, RA. Risedronate activity in the fetal and neonatal

mouse. Otolaryngology - Head and Neck Surgery 109(4):623-633, October. 110. 1993 Chole, R. A. Cholesteatoma - Conference Summary. In: Nakano Y, ed. Cholesteatoma

and Mastoid Surgery. Proceedings of the Fourth International Conference. Amsterdam/New York, Kugler Publications, pp. 835-840.

111. 1993 Chole, RA. Gerbil model of aural cholesteatoma. In: Nakano Y, ed. Cholesteatoma and

Mastoid Surgery. Proceedings of the Fourth International Conference. Amsterdam/New York, Kugler Publications, pp. 367-369.

112. 1993 Chole, RA. Bone resorption in aural cholesteatoma. In: Nakano Y, ed. Cholesteatoma

and Mastoid Surgery. Proceedings of the Fourth International Conference. Amsterdam/New York, Kugler Publications, pp. 79-83.

113. 1994 Chole, RA. Cholesteatoma. In: Gates GA, ed. Current Therapy in Otolaryngology, Fifth

Edition, St. Louis, Mosby-Year Book, Inc. 114. 1994 Chole, RA., Tinling, SP and Faddis, BT. Human recombinant interleukin-1 receptor

antagonist blocks bone resorption induced by interleukin-1ß but not interleukin-1 . Calcified Tissue International. 55 (1):12-15, July.

115. 1994 Chole, RA. Ossiculoplasty with presculpted banked cartilage. Otolaryngologic Clinics of

North America, 27 (4):717-726, August. 116. 1994 Tinling, SP and Chole, RA. Apical cochlear nerve exposed to perilymph in the gerbil and

rat. Hearing Research, 73:203-208. 117. 1994 Chole, RA and Tinling, SP. Bone lining cells of the mammalian cochlea. Hearing

Research, 75:233-243. 118. 1995 Parker, WS and Chole, RA. Tinnitus, vertigo, and temporomandibular disorders. The

American Journal of Orthodontics and Dentofacial Orthopaedics, 107 (2):153-158, February.

119. 1995 Chole, RA, Faddis, BT and Tinling, SP. In vivo inhibition of localized bone resorption by

human recombinant interleukin-1 receptor antagonist. Journal of Bone and Mineral Research, 10 (2):281-284, February.

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120. 1995 Chole, RA. Antimicrobial activity of silver oxide impregnated silastic tympanostomy tubes: A double-blind randomized multicenter trial. Archives of Otolaryngology - Head and Neck Surgery. Archives of Otolaryngology, 121 (5): 562-565, May.

121. 1995 Postma, G, Chole, RA and Nemsek, WR. Reversible blindness secondary to acute

sphenoid sinusitis. Otolaryngology - Head and Neck Surgery, 112:742-746, June. 122. 1995 Chole, RA, Brummett, RE and Tinling, SP. Safety of silver oxide impregnated silastic

tympanostomy tubes. American Journal of Otology, 16 (6): 722-724, November. 123. 1995 Sherman, BE and Chole, RA. A mechanism for sympathectomy-induced bone resorption

in the middle ear. Otolaryngology-Head and Neck Surgery 113(5): 569-581, November. 124. 1996 Bohrer, PS and Chole, RA. Unusual lesions of the internal auditory canal. The American

Journal of Otology, 17(1): 143-149, January. 125. 1996 Chole, RA and Kim, H-J. Ossiculoplasty with presculpted banked cartilage. Operative

Techniques in Otolaryngology-Head and Neck Surgery 7(1): 38-44, March. 126. 1996 Sherman, BE and Chole, RA. The in-vivo effects of surgical sympathectomy on

intramembranous bone resorption. American Journal of Otology, 17(2): 343-346, March. 127. 1996 Corcoran, ME, Chole, RA, Sykes, JM and McKennan, KX. Ointment granuloma

complications after cosmetic and otologic surgery. Otolaryngology-Head and Neck Surgery, 114(4): 634-8, April.

128. 1997 Corcoran, ME, Lim, JY and Chole, RA. Prophylaxis for Oral Surgery and Fractures of the

Facial Skeleton. Infectious Diseases and Antimicrobial Therapy of the Ears, Nose and Throat, 71:619-622, January.

129. 1997 Stevenson, T, Whetzel, T and Chole, RA. Salary Guidelines for Academic Plastic Surgery

Faculty. Plastic and Reconstructive Surgery, 99:1180-1183, April. 130. 1997 Sykes, JM and Chole, RA. Dynamic analysis of changes in the nasolabial fold using

magnetic resonance imaging: implications for facial rejuvenation and facial reanimation surgery. Otolaryngology Journal Club Journal.

131. 1997 Chole, RA. The molecular biology of bone resorption due to chronic otitis media. Ann N

Y Acad Sci. 830:95-109, December 29. 132. 1998 Kim, H-J and Chole RA. Experimental models of aural cholesteatomas in Mongolian

gerbils. Annals of Otology, Rhinology, and Laryngology, 107:(2):129-134, February. 133. 1998 Chole, RA. Second Workshop of the NIDCD Working Group on Early Identification of

Hearing Impairment: Characterization of Auditory Performance and Intervention Strategies Following Neonatal Hearing Screening, Rockville, Maryland, March 13, 1998.

134. 1998 Chole, RA. and Tinling, SP. Adaptive bone modeling in the middle ear is substance-p

dependent. Am J of Otology, 19(4):521-524, July. 135. 1998 Chole, RA and Brodie, HA. Surgery of the mastoid and petrosa. In: Bailey B J, 2nd ed.

Head and Neck Surgery - Otolaryngology Philadelphia, J.B. Lippincott Company, Chapter 139.

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136 1998 Chole, RA, Tinling, SP, Leverentz, E and McGinn, MD. Inhibition of nitric oxide synthase blocks osteoclastic bone resorption in adaptive bone modeling. Acta Oto-Laryngologica, 118:705-711.

137. 1998 Chole, RA and Choo, M-J. Chronic otitis media, mastoiditis and petrositis. In:

Cummings, Fredrickson, Harker, Krause, Schuller, eds. Otolaryngology-Head and Neck Surgery, Third Edition.

138. 1998 Chole, RA. Otologic manifestations of systemic disease, questions and answers.

Otolaryngology - Head and Neck Surgery Re-Certification Study Guide, June. 139. 1999 Choo, M-J and Chole, RA. Cytochrome P450 inhibition blocks bone resorption in vitro

and in vivo. Otolaryngology - Head and Neck Surgery, Volume 120, Number 1, January. 140. 1999 Johnson JT, Victor LY and Chole, RA. Prophylasix for Oral Surgery and Fractures of the

Facial Skeleton. In Infectious Diseases and Antimicrobial Therapy of the Ears, Nose and Throat, W.B. Saunders Company, , 2nd ed. Chapter 71:619-622.

141. 1999 Chole, RA and Skarada, DJ. Middle Ear Reconstructive Techniques. Otolaryngologic

Clinics of North America, submitted December. 142. 1999 Sherman, BE and Chole, RA. Effect of Pharmacological Sympathectomy on Osteoclastic

Activity in the Gerbilline Auditory Bulla in vivo. Annals of Otology, Rhinology and Otolaryngology. Vol. 108(11):1078-87, November.

143. 1999 Chole, RA and Young N. Cytokine-mediated Bone Resorption is Cytochrome P-450

Dependent. Otolaryngology-Head and Neck Surgery. Vol.121(6):708-712, December. 144. 2000 Sherman BE and Chole, RA. Sympathectomy, Which Induces Intramembranous Bone

Remodeling, Has No Effects on Endochondral Long Bone Remodeling in vivo. Journal of Bone and Mineral Research, Vol. 15(7):1354-1360, January.

145. 2000 Sherman, BE and Chole, RA. Effects of Leukotriene and Cyclo-oxygenase Inhibition on

Adaptive Bone Remodeling in the Middle Ear. Otolaryngology-Head and Neck Surgery, Vol. 123:1:1:1-8.July. (First Place - Resident Basic Science Award 1999)

146 2001 Chole, RA, Faddis BT, Chamberlain S and Magilke D. Invasiveness of fibroblasts from

experimental cholesteatomas. Otology & Neurotology, Vol. 22:15-17. 147. 2001 Sherman, BE and Chole, R.A. Effect of Chemical Sympathectomy with 6-

Hydroxydopamine on Osteoclast Activity in the Gerbilline Middle Ear Bulla. Otology and Neurotology. Vol. 22(2):237-241, March.

148. 2001 Chole, RA and McKenna M. Pathophysiology of Otosclerosis. Otology and Neurotology.

Vol 22(2):249-257, March. 149. 2001 Kim H-J, Tinling SP and Chole, RA. Expression patterns of cytokeratins in retraction pocket cholesteatoma. The Laryngoscope, 111:6:1032-1041, June. 150. 2001 Chole, RA, Hughes RM and Faddis BT. Keratin particle-induced osteolysis: A mouse

model of inflammatory bone remodeling related to cholesteatoma. Journal of the Association for Research in Otolaryngology. 2 (1):65-71, March.

151. 2001 Sherman, BE and Chole, RA. Effects of catecholamines on calvarial bone resorption in

vitro. Annals of Otology, Rhinology & Laryngology, 110:7:682-689, July.

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152. 2001 Jacob A, Faddis BT and Chole, RA. Chronic Bacterial Rhinosinusitis: Description of a Mouse Model. Archives of Otolaryngology-Head and Neck Surgery, 127:657-664, June. 153. 2002 Jacob A, Faddis BT and Chole, RA.. MeroGel Hyaluronic Acid Sinonasal Implants:

Osteogenic Implications. Laryngoscope, 112 (1): 37-42, January. 154. 2001 Chole, RA and Brodie HA. Surgery of the Mastoid and Petrosa. In: Head & Neck

Surgery - Otolaryngology, 3e Bailey, ed. Chapter 141 2002 Chole, RA and Forsen WJ. Color Atlas of Ear Disease, 2nd Edition. B.C. Decker, Inc.,

Hamilton, London 155. 2002 Jung JY and Chole, RA. Bone Resorption in Chronic Otitis Media: The Role of the Osteoclast. ORL - Journal for Oto-Rhino-Laryngology and Its Related Specialties, S. Karger AG, Basel, Medical and Scientific Publishers, 64:95-107, March-April. 156. 2002 Chole, RA and Faddis BT. Evidence for Microbial Biofilms in Cholesteatomas. Archives of Otolaryngology-Head & Neck Surgery, June. 157. 2002 Young N and Chole, RA. The Retraction Pocket Cholesteatoma, Current Opinions in

Otolaryngology, 10:5; 355-359, October. 158. 2002 Kim HJ, Tinling SP and Chole, RA. Expression patterns of cytokeratins in

cholesteatomas: Evidence of increased migration and proliferation. Journal of Korean Medical Science, 17(3):381-8, June.

159. 2002 Kim HJ, Tinling SP and Chole, RA. Increased proliferation and migration of epithelium in advancing experimental cholesteatomas. Otology & Neurotology, 23:6, 840-844. 160. 2002 Hartman JM and Chole, RA. Headache & Facial Pain in Ballenger's Otorhinolaryngology- Head and Neck Surgery, 16th Edition, December. 161. 2002 Chole, RA and Faddis BT. Evidence for microbial biofilms in cholesteatomas. Archives of Otolaryngology, 128(1):1129-033, October. 162. 2003 Jung JY, Lin AC, Ramos, LM, Faddis BT and Chole, R.A. Nitric oxide synthase I

mediates osteoclast activity in vitro and in vivo. Journal of Celllular Biochemistry, 89:613-621.

163. 2003 Chole, RA and Faddis, BT. Anatomic evidence of microbial biofilms in tonsillar tissues –

A possible mechanism to explain chronicity. Archives of Otolaryngology, 129: 634-636, June.

164. 2003 Sudhoff H, Jung J, Ebmeyer J, Faddis BT and Chole, RA. Zoledronic acid inhibits

osteoclastogenesis in vitro and in a mouse model of inflammatory osteolysis. Annals of Otology, Rhinology & Laryngology, 112:9, 780-786, September.

165. 2004 Jung JY, Pashia ME, Nishimoto SY, Faddis BT and Chole, RA. A possible role for nitric

oxide in cholesteatoma induced bone resorption. Otology & Neurotology, 24(5): 661-668, September.

166. 2004 Lansford CD, Fisher SR, Ossoff RH and Chole, RA. Otolaryngology-head and neck

surgery residency match: applicant survey. Arch Otolaryngol Head Neck Surg. 130(9): 1017-23, September.

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167. 2005 Wang EW, Pashia, ME, Jung JY and Chole, RA. Otopathogenic Pseudomonas aeruginosa exhibits biofilm-forming characteristics: initial observations (IN) the Proceedings of the 8th International Symposium on Recent Advances in Otitis Media , June 3-7. 2003, (BC Decker, Inc., Publisher), pp 261-264

168. 2005 Jung JY, Pashia ME, Wang EW and Chole, RA. Preliminary evidence of

lipopolysaccharide-dependent and lipopolysaccharide-independent osteoclastogenesis by otopathogenic Pseudomonas aeruginosa (IN) the Proceedings of the 8th International Symposium on Recent Advances in Otitis Media , June 3-7. 2003, (BC Decker, Inc., Publisher), pp 261-264

169. 2005 Lim DJ, Hellstrom SL, Alper CM, Andalibi A, Bakaletz LO, Buchman CA, Caye-Thomasen

P, Chole, RA., et al. Animal models; anatomy and pathology; pathogenesis; cell biololgy and genetics, Annals of Otology, Rhinology & Laryngology, Recent Advances in Otitis Media Report of the Eighth Research Conference, Supplement 194, Vol. 114, Number 1, Part 2, January.

170. 2005 Wang EW, Jung JY, Pashia-Basse ME, Nason R, Scholnick SB and Chole, RA.

Otopathogenic Psudomonas aeruginosa as competent biofilm formers. Archives of Otolaryngology-Head & Neck Surgery, 131:983-989, November.

171. 2006 Tinling SP and Chole RA. Gerbilline Cholesteatoma Development I. Epithelial migration

pattern and rate on the gerbil tympanic membrane: Comparisons with human and guinea pig, Oto-Head & Neck Surgery, May 134: 788-793.

172. 2006 Tinling SP and Chole RA. Gerbilline Cholesteatoma Development II. Temporal

histopathologic changes in the tympanic membrane and middle ear, Oto-Head & Neck Surg, 134: 953-960, June 134(6):953-60.

173. 2006 Tinling SP and Chole RA. Gerbilline Cholesteatoma Development III. Increased

proliferation index of basal keratinocytes of the tympanic membrane and external ear canal, accepted Oto-Head & Neck Surg, July 135(1):116-23.

174. 2006 Jacob A and Chole RA. Survey Anatomy of the Pararnasal Sinuses in the Normal

Mouse, The Laryngoscope, 116:4; 558-563, April. 175. 2006 Kim H-J, Park IS, Lee HB, Lee JS and Chole RA. Functional and Morphologic Inner Ear

Changes in Guinea Pigs Caused by Administration of Various Bisphosphonates to the Round Window. Tissue Engineering and Regenerative Medicine, 3 (2): 137-141, July.

176. 2006 Grandis JR, Battey JF, et al. Research Education and Training in Otolaryngology:

Meeting Summary and Research Opportunities. Oto-Head Neck Surgery, 135, 361-367. 177. 2007 Piccirillo JF, Finnell J, Vlahiotis A, Chole RA, Spitznagel E. Relief of Idiopathic Subjective

Tinnitus: Is Gabapentin Effective?, Arch Otolaryngol Head Neck Surgery, 113(4): 390-397, April.

178. 2007 Zhuang L, Jung JY, Wang EW, Houlihan P, Ramos L, Pashia M and Chole RA.

Pseudomonas aeruginosa Lipopolysaccharide Induces Osteoclastogenesis Through a Toll-Like Receptor 4 Mediated Pathway in Vitro and in Vivo, Laryngoscope, 117:841-847, May.

179. 2007 Hartman JM, Yu, JW and Chole, RA. Headache & Facial Pain in Ballenger's

Otorhinolaryngology-Head and Neck Surgery, 17th Edition (Chapter 48).

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180. 2007 Nason R and Chole, RA. Bacterial Biofilms May Explain Chronicity in Osteoradionecrosis of the Temporal Bone, Otol Neurotol, Dec 28 (8):1026-8.

181 2008 Wang EW, Agostini G, Olomu O, Runco D, Jung JY and Chole RA. Gentian violet and

Ferric ammonium citrate disrupt P. aeruginosa biofilms. Laryngoscope 118. 182 2008 Chole RA., Olomu O and Wang EW. Bacterial biofilm infections in otology. Recent

Advances in Otolaryngology, pgs 21-31. 183. 2008 Finley CC, Holden TA, Holden LK, Whiting BR, Chole RA, Neely JG, Hullar TE and

Skinner, MW. Role of electrode placement as a contributor to variability in cochlear implant outcomes. Otology & Neurotology, 29:7, 920-928, July.

184. 2009 Chole, RA and Nason R. Chronic Otitis Media and Cholesteatoma in Ballenger's

Otorhinolaryngology-Head and Neck Surgery, 17th Edition – Centennial Edition (Chapter 17).

185. 2009 Nason R, Jung JY and Chole RA. Lipopolysaccharide-Induced Osteoclastogenesis from

Mononuclear Precursors: A Mechanism for Osteolysis in Chronic Otitis. Journal of the Association of Research in Otolaryngology, January, epub ahead of print.

186. 2009 Nason R, Lee DH, Jung JY and Chole RA. Radiographic and micro-computed

tomographic imaging of lipopolysaccharide-mediated bone resorption. Ann Otol Rhinol Laryngol, May;118(5):391-396.

187. 2009 Uchanski RM, Davidson LS, Quadrizius S, Reeder R, Cadieux J, Kettel J and Chole RA.

Two ears and two (or more?) devices: a pediatric case study of bilateral profound hearing loss. Trends in Amplification, June; 13(2):107-23.

188. 2009 Meshik X, Holden TA. Chole RA and Hullar TE. Optimal Cochlear Implant Insertion

Vectors. Otol Neurotol. August 24. (epub ahead of print); Otol Neurotol. 2010 Jan;31(1):58-63.

189. 2010 Chole RA. Labs in Crisis: Protecting the Science-and-Art of Otopathology. Otol

Neurotol. April 29 (Epub ahead of print); Otol Neurotol. Jun; 31(4):554-556. 190. 2010 Brown RF, Hullar, TE, Cadieux JH and Chole RA. Residual hearing preservation after

pediatric cochlear implantation. Otol Neurotol.Oct;31(8):1221-1226. 191. 2010 Chole RA, Lim C, Dunham B, Chicoine M and Dacey R. A Novel Transnasal

Transsphenoidal Speculum – A Design for Both Microscopic and Endoscopic Transsphenoidal Pituitary Surgery – Technical Note. Journal of Neurosurgery, May: 114(5):1380-1385, Epub, Jan 7, 2011.

192. 2010 Jung, JY, Lee DH, Wang EW, Nason R, Sinnwell TM and Chole RA. Infection results in

cholesteatoma with greater morbidity in a gerbil model. The Laryngoscope, November. 193. 2010 Chole RA and Nussenbaum B. Is there a role for new technologies in patient safety?

Letter to the Editor, New England Journal of Medicine, November. 194. 2010 Voelker CCJ and Chole RA. Unilateral Sensorineural Hearing Loss in Adults: Etiology

and Management. Seminars in Hearing, Fitting Options for Children and Adults with Single-Sided Deafness, Thieme New York – Stuttgart. Vol. 31:4. 313-325,November.

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195. 2011 Teymouri J, Hullar TE, Holden TA, Chole RA. Verification of computed tomographic estimates of cochlear implant array position: A micro-CT and histological analysis. Otology & Neurotology, August; 32(6):980-986.

196. 2011 Graboyes E, Hullar TE, Chole RA. History of Otology: The Lenticular Process of the Incus, Otology & Neurotology, Dec;32(9):1600-4.

197. 2011 Jung JY, Lee DH,, Wang EW, Nason R, Sinwell TM, Vogel JP, Chole RA. P aeruginosa infection increases morbidity in experimental cholesteatomas, Laryngoscope, Nov;121(11):2449-2454. PMID: 22020895

198. 2011 Graboyes EM, Chole RA, Hullar TE. The ossicle of Paaw, Otology & Neurotology, Otol

Neurotol. 2011 Sep;32(7):1185-8. 199. 2012 Chole RA. Superior semicircular canal obliteration for superior semicircular canal

dehiscence syndrome: middle cranial fossa and transmastoid approach. In Marcos Goycoolea & Friends Atlas of Otologic Surgery and Magic Otology, Vol 2, 6.2.3D, 1105-1109.

200. 2012 Oeding K, Valente M, Chole RA. Challenges in fitting a hearing aid to a severely collapsed ear canal and mixed hearing loss. J Am Acad Audiol. Apr;23(4):276-82. PMID: 22463941

201. 2012 Chole RA, Zenga J, Gagnon P, Vogel J. Biofilm formation by otopathogenic strains of P. aeruginosa is not consistently inhibited by EDTA, Otology & Neurotology, 2012 Aug:33(6):1007-12, PMID: 22772018.

202. 2012 Chole RA and Ogden MA. Predictors of Future Success in Otolaryngology Residency

Applicants, Archives of Otolaryngology-Head & Neck Surgery, 2012 Aug:138(8):707-12, PMID: 22911295.

203. 2013 Firszt JM, Reeder RM, Holden TA, Burton H, Chole RA. Changes in auditory perceptions

and cortex resulting from hearing recovery after extended congenital unilateral hearing loss, Front Syst Neurosci, 2013 Dec 13;7:108, PMID: 24379761.

204. 2014 Sylvester PT, Evans JA, Zipfel BJ, Chole RA, Uppaluri R, Haughey BH, Getz AE,

Silverstein J, Rich KM, Kim AH, Dacey RG, Chicoine MR. Combined high-field intraoperative magnetic resonance imaging and endoscopy increase extent of resection and progression-free survival for pituitary adenomas. Pituitary, 2014 Mar 6, PMID: 24599833.

205. 2014 Chole RA. Endoscopic View of the Scala Tympani, Otology & Neurotology, 2014 June 2

(epub ahead of print), PMID: 24892372. 206. 2014 Sharon JD, Khwaya SS, Drescher A, Gay H, Chole RA. Osteoradionecrosis of the

temporal bone: A case series, Otology & Neurotology, 2014 June 9, (epub ahead of print), PMID: 24914789.

207. 2014 Potts L, Chole RA. Conductive Hearing Loss and Cochlear Implantation in Patients with

Residual Hearing Conservation American Journal of Audiology, accepted for publication 2014

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49

IN PRESS 1. 1997 Kim, H-J., Tinling, SP and Chole RA. Changes of the Cytokeratin Expression in

Experimental Cholesteatomas. In: Sanna M, ed. Cholesteatoma and Mastoid Surgery: Fifth International Conference.

2. 1997 Kim, H-J, Tinling, SP and Chole RA. Gerbilline Models of Aural Cholesteatoma. In:

Sanna, M. ed. Cholesteatoma and Mastoid Surgery: Fifth International Conference. SUBMITTED 1. 1995 Bohrer, P. and Chole, R.A. Intracanalicular meningioma. XXIII Pan American Congress

of Otorhinology - Head and Neck Surgery, July. ABSTRACTS 1. 1977 Chole, R. A. Experimental studies on the role of vitamin A in the inner ear. Dissertation

Abstracts International 38(3). 2. 1977 Chole, R. A. and C. A. Quick. Temporal bone histopathology in experimental

hypovitaminosis, p. 66-68. Paparella and Strong, Eds. 1977 Yearbook of Otolaryngology, Year Book Medical Publishers, Inc., March.

3. 1978 Chole, R. A. and G. H. Domb. Superficial ulcerations of the oral cavity. Otolaryngology-

Head and Neck Surgery 86(4): 215, July-August. 4. 1978 Chole, R. A. and D. J. Kiener. The endolymphatic sac - its surgical location.

Otolaryngology-Head and Neck Surgery 86(4): 215, July-August. 5. 1978 Chole, R. A. Squamous metaplasia of middle ear mucosa during vitamin A deprivation.

Abstracts of the Association for Research in Otolaryngology, American Academy of Otolaryngology.

6. 1979 De Clercq, L. D. and Chole, R.A. Retropharyngeal abscess in the adult. Otolaryngology-

Head and Neck Surgery 87(4), Section 2: 233, July-August. 7. 1979 Domb, G. H. and Chole, R.A. Scrofula. Otolaryngology-Head and Neck Surgery 87(4),

Section 2: 237, July-August. 8. 1980 Chole, R. A. Vitamin A and otitis media. Western Journal of Medicine (Epitome) 133(4):

327, October. 9. 1980 Shea, D. A., Chole, R.A. and M. M. Paparella. The endolymphatic sac: Anatomical

considerations, p. 15-16. In 1980 Yearbook of Otolaryngology, Paparella and Strong (Eds.), Yearbook Medical Publishers, Inc.

10. 1980 Chole, R. A. Aural cholesteatoma in the Mongolian gerbil. Otolaryngology-Head and

Neck Surgery.

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11. 1982 Chole, R. A. Ossicular replacement with self-stabilizing presculptured homologous cartilage. ORL Digest (International Synopses), pages 14-15.

12. 1983 Ferrell, F., Chole, R.A. and T. Tsuetaki. Developmental time course of myelination in

chorda tympani nerve of postnatal rat, Abstract #36. Proceedings of the Fifth Annual Meeting of the Association for Chemoreception Sciences, Sarasota, Florida.

13. 1984 McGinn, M. D. and Chole, R.A.. Gerbilline cholesteatoma: Effects on cochlear hair cells.

A scanning electron microscope study. Association for Research in Otolaryngology, American Academy of Otolaryngology.

14. 1984 Chole, R. A. and K. R. Henry. Otosclerosis: An animal model. Otolaryngology-Head

and Neck Surgery, Contents, Special Issue #82. 15. 1984 Chole, R. A. and K. R. Henry. Otosclerotic lesions in the inbred LP/J mouse (Science

221: 881-882). Abstract in the American Journal of Otolaryngology 5(2): 152. 16. 1984 Chole, R. A. and S. P. Tinling. Basal lamina breaks in the histogenesis of cholesteatoma.

Transactions of the American Laryngological, Rhinological and Otological Society, pg. 61. 17. 1984 Chole, R. A. Osteoclasts in cholesteatoma bone resorption. Abstract in "extracta" series

issued by ACRON Publishers, from article in Laryngoscope 94: 76-95. 18. 1985 Chole, R. A. Zellulare und subzellulare Aspekte der Knochenresorption beim

Cholesteatom des Menschen und im Tierversuch: Die Rolle der Osteoklasten. Abstract in "Osteoclasts in Cholesteatoma Bone Resorption" Laryngoscope 94: 76-95, published in Extracta Otorhinolaryngologica, Band 7, Heft 4.

19. 1985 Wolfman, D. E. and Chole, R.A. Osteoclast stimulation by positive middle ear air

pressure. Transactions of the American Academy of Otolaryngology-Head and Neck Surgery.

20. 1986 Orisek, B. S. and Chole, R.A. Pressures exerted by experimental cholesteatomas.

Transactions of the American Academy of Otolaryngology-Head and Neck Surgery. 21. 1986 Brodie, H. A. and Chole, R.A. Recurrent pneumosialadenitis: A case presentation and

new surgical intervention. Otolaryngology-Head and Neck Surgery. 22. 1986 Baker, R. S. and Chole, R.A. Topical gentamicin prophylaxis in myringotomy and

ventilating tube placement. Otolaryngology-Head and Neck Surgery. Special issue for AAO meeting, August, p.46, August.

23. 1986 Baker, R. S. and Chole, R.A. Topical tentamicin prophylaxis in myringotomy and

ventilating tube placement. Reprint from "Special Issue" of Otolaryngology-Head and Neck Surgery, p. 12, August.

24. 1986 Chole, R. A. and J. Yee. Antibiotic prophylaxis for facial fractures: A prospective,

randomized trial. Otolaryngology-Head and Neck Surgery. Special issue for AAO Meeting, p. 59, August.

25. 1987 Weissler, M. D., Chole, R.A. Prophylactic antibiotics for facial fractures: RE: "Antibiotic

prophylaxis for facial fractures: A prospective, randomized trial," Archives of Otolaryngology, 113: 19, January.

26. 1987 Chole, R. A. Use of presculpted, banked cartilage transplants in ossicular reconstruction.

JAMA, Specialty Abstracts, 257(18): 2431, May.

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27. 1987 Brodie, H. A., Chole, R.A., M. B. Shannon and K. H. Henry. The effect of sodium fluoride

on the dysplastic bony lesions and auditory brainstem responses in LP/J mice. Otolaryngology-Head and Neck Surgery. Special issue for AAO Meeting, August.

28. 1987 Henry, K. R. and Chole, R.A. The otosclerotic-like condition of the LP/J mouse: Genetic

transmission and functional losses. Abstracts of the Tenth Midwinter Research Meeting, Association for Research in Otolaryngology, p. 169.

29. 1988 Chole, R.A. The role of osteoclasts in middle ear disease. Abstract accepted for

presentation at the American Otological Society Meeting, April. 30. 1988 Chole, R. A. and J. Yee. Antibiotic prophylaxis for facial fractures: A prospective,

randomized clinical trial. Archives of Otolaryngology 1987; 105:1055-1057. Referenced in "Preventing infection after facial fractures," Emergency Medicine, pp. 117-120, April.

31. 1988 Chole, R. A. Mechanisms of osteoclast activation in cholesteatoma. Abstracts of the

Third International Conference on Cholesteatoma and Mastoid Surgery, Copenhagen, Denmark, M. Tos, Ed., June.

32. 1988 R. S. Baker and Chole, R.A. A randomized clinical trial of topical gentamicin after

tympanostomy tube placement. Archives of Otolaryngology-Head and Neck Surgery; 114:755-757. Abstracted in JAMA 260(24): 3666, December.

33. 1989 Chole, R. A. and J. Yee. Antibiotic prophylaxis for facial fractures: A prospective, randomized clinical trial. Archives of Otolaryngology; 105:1055-1057. Abstracted in 1989 Year Book of Otolaryngology-Head and Neck Surgery, B. J. Bailey, Ed., Year Book Medical Publishers, Chicago.

34. 1989 Tinling, S. P. and Chole, R.A. Spontaneous cholesteatoma in gerbils: Preliminary

observations. Abstracts of the Third International Conference on Cholesteatoma and Mastoid Surgery, Copenhagen, Denmark, M. Tos, Ed., June.

35. 1989 Chole, R. A. Air pressure induced bone remodeling: A quantifiable model of localized

bone resorption. Transactions of the 35th Annual Meeting, Orthopaedic Research Society, p.12.

36. 1989 Gleeson, Michael. In Clinical Otolaryngology. RE: Chole, R. A. A Colour Atlas of Ear

Disease, Wolfe Medical Publications, London, 1988. 37. 1990 Paparella, Michael M. In: 1990 Year Book of Otolaryngology - Head and Neck Surgery.

RE: Chole, R. A. and M. Chiu: Cochlear hair cell stereocilia loss in LP/J mice with bone dysplasia of the middle ear. Ann Otol Rhinol Laryngol 98: 461-465.

38. 1990 Paparella, Michael M. In: 1990 Year Book of Otolaryngology - Head and Neck Surgery.

RE: McKennan, K. X. and Chole, R.A.: Post-traumatic cholesteatoma. Laryngoscope 99:779-782.

39. 1990 Adachi, K. and Chole, R.A. 1-Hydroxyethylidiene-1,1 bisphosphonate (HEBP) inhibits

recruitment of osteoclasts to a local site. Abstract in Clinical Research 1989; 37(1):221A. 40. 1990 Adachi, K. and Chole, R.A.. Inhibition of osteoclast recruitment at a local site by 1-

hydroxyethylidene-1, 1-bisphosphonate (HEBP). Abstract in Ann Otol Rhinol Laryngol 99: 738-741.

41. 1991 Richardson, A. and Chole, R.A.. Congenital lip pits. Transactions of the American

Academy of Otolaryngology - Head and Neck Surgery.

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42. 1991 Corcoran, M. E. and Chole, R.A.. Diffuse neurofibroma of the head and neck.

Transactions of the American Academy of Otolaryngology - Head and Neck Surgery. 43. 1992 Chole, R. A. Osteoclasts and bone lining cells: A role in ear disease. First Annual

Updates in Biomedical Research and Teaching Symposium, October. 44. 1992 Chole, R. A. and William S. Parker. Tinnitus and vertigo in patients with

temporomandibular disorder. Clinical Digest Series. 45. 1992 Blazun, J. M., Chole, R.A. and S. P. Tinling. Effect of bisphosphonates on osteoclast

activation using a pressurized middle ear model. Submitted to Research Forum, March. 46. 1992 Bohrer, P. and Chole, R.A. Intracanalicular meningioma. Submitted to the XXIII Pan

American Congress of Otorhinolaryngology - Head and Neck Surgery, July. 47. 1993 Chole, R. A. Antimicrobial activity of silver oxide impregnated silicone elastomer

tympanostomy tubes: A randomized multicenter trial. Abstract for presentation at the American Otological Society, Palm Beach, October.

48. 1993 Chole, R. A. and Tinling, SP. Incomplete coverage of mammalian bone matrix by lining

cells. Abstract in Ann Otol Rhinol Laryngol 102:543-550. 49. 1996 Chole, R. A. Anesthetic considerations in otologic and neurologic surgery. Abstract for

presentation at the 63rd Annual Meeting of the American Association of Nurse Anesthetists, Philadelphia, Pennsylvania, August.

50. 1996 Chole, R. A. Avoiding catastrophe in airway surgery. Abstract for presentation at the

63rd Annual Meeting of the American Association of Nurse Anesthetists, Philadelphia, Pennsylvania, August.

51. 1996 Chole, R. A. The molecular biology of bone resorption due to chronic otitis media.

Abstract presentation at the Symposium on Immunological Diseases of the Ear, Positano, Italy, October.

52. 1997 Chole, R. A. and S.P. Tinling. Adaptive bone remodeling is substance P dependent.

Abstract presentation at the Annual meeting of the Association for Research in Otolaryngology.

53. 1999 Jung J, Tinling S, Jungkeit MC, Chole K, Chole, R.A. The effect of plasminogen

activators on bone resorption in tissue culture. Abstract presented at the 22nd Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 13-18.

54. 2000 Jung J, Faddis BT, Hughes R, Chole, R.A. Nitric oxide donor inhibits OPGL-induced

osteoclast development. Abstract presented at the 23rd Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 20-24.

55. 2000 Jacob A, Faddis BT, Chole, R.A. Cellular and molecular biology of chronic sinusitis: A

mouse model. Abstract presented at the 23rd Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 20-24.

56. 2000 Sudhoff H, Ebmeyer J, Antonopoulos A, Hildmann H, Borkowski G, Faddis BT, Chole,

R.A. Bone resorption and possibilities of its inhibition in cholesteatoma tissue culture. Abstract presented at 6th International Conference on Cholesteatoma and Ear Surgery, Cannes, France, June 29-July 2.

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57. 2000 Chole, R.A. Animal model for the study of cholesteatoma: recent advances. Abstract

presented at 6th International Conference on Cholesteatoma and Ear Surgery, Cannes, France, June 29-July 2.

58. 2000 Chole R.A. Molecular biology of osteoclast control in cholesteatoma. Abstract presented

at 6th International Conference on Cholesteatoma and Ear Surgery, Cannes, France, June 28-July 2.

59. 2000 Chole R.A. Murine Model of Bone Resorption Due to Cholesteatoma. Abstract

presented at the Collegium Meeting in Washington, DC, August 27-30, 2000. 60. 2001 Sudhoff H, Jung J, Ebmeyer J, Faddis, BT, Chole R.A. Zoledronate inhibits

osteoclastogenesis in vitro and in keratin particle-induced inflammatory osteolysis in a mouse model. Abstract presented at the 24th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 4-8.

61. 2001 Young NO, Davis ME, Faddis BT, Chole R.A. Demonstration of cytochrome p450 in

OPGL-induced osteoclast culture. Abstract presented at the 24th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 4-8.

62. 2001 Jung J, Lin AC, Faddis BT, Chole, R.A. Nitric oxide stimulates osteoclast activity and

mediates cytokine-induced bone resorption. Abstract presented at the 24th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 4-8.

63. 2001 Faddis BT, Hughes RM, Davis ME, Elluru RG, Chole, R.A. Early events in

osteoclastogenesis following keratin implantation in the mouse. Abstract presented at the 24th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 4-8.

64. 2001 Lin AC, Jung JY Faddis BT, Chole R. A. IL-1 stimulates osteoclast differentiation and

increases bone resorption volume in vitro. Abstract presented at the 24th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, February 4-8.

65. 2002 Jung JY, Lin AC, Pashia ME, Nance M, Nishimoto S, Hughes RM, Faddis BT, Chole,

R.A. Nitric oxide synthase (NOS I mediates osteoclast activity in vitro and in vivo. Abstract presented at the 25th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, January 27-31.

66. 2002 Nance MA, Lin AC, Jung JY, Faddis BT, Chole, R.A. IL-1beta stimulates osteoclast

formation and activity independent of osteoblasts and mediates inflammatory bone resorption. Abstract presented at the 25th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, January 27-31.

67. 2002 Young NO, Faddis BT, Chole, R.A. Vitamin D stimulates osteoclast activation and

recruitment in the RANKL-Osteoclast culture. Abstract presented at the 25th Annual Midwinter Meeting of the Association for Research in Otolaryngology, St. Petersburg Beach, FL, January 27-31.

68. 2002 Chole R.A., Faddis BT. Microbial biofilms in cholesteatomas. Abstract presented at the

Collegium Oto-Rhino-Laryngologicum Amicitae Sacrum Meeting in Noordwijk, the Netherlands, August 25-28.

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69. 2003 Jung JY, Pashia ME, Wang E, Chole R.A. Evidence of LPS-dependent and LPS-independent Osteoclastogenesis by Otopathogenic Pseudomonas aeruginosa (OPPA), 8th International Symposium on on Recent Advances in Otitis Media, June 3-7.

70. 2003 Wang E, Pashia ME, Jung JY, Chole RA. Otopathogenic Pseudomonas aeruginosa

(OPPA) can adhere to keratinocytes and express quorum sensing genes, 8th International Symposium on Recent Advances in Otitis Media, June 3-7.

71. 2003 Wang E, Pashia ME, Jung JY, Chole R.A. Phenotype of otopathogenic P.aeruogionoas

implicates cholesteatoma as a biofilm disease. American Academy of Otolaryngology-Head and Neck Surgery Annual Meeting, September 21-24.

72. 2004 Chole R.A., Pashia-Basse M, Nason R, Zhuang L. Cholesteatoma infection:

Characterization of otopathogenic pseudomonas aeruginosa (OPPA). 7th International Conference on Cholesteatoma & Ear Surgery, June 22-26.

73. 2005 Nason R, Jung JY, Wang E, Chole R.A. Invasion of human keratinocytes by

otopathogenic Pseudomonas aeruginosa. Abstract submitted to the 27th Annual Midwinter Meeting of the Association for Research in Otolaryngology, New Orleans, LA, February 19-23.

74. 2005 Zhuang L, Jung JY, Chole R.A. Role of Pseudomonas aeruginosa lipopolysaccharide on

osteoclastogenesis and toll like receptor activation. Abstracted submitted to the 27th Annual Midwinter Meeting of the Association for Research in Otolaryngology, New Orleans, LA, February 19-23.

75. 2005 Jung JY, Nason R,Wang E, Pashia ME, Cornelius LA, Chole R.A. Pseudomonas

aeruginosa adhesion and invasion of human keratinocytes. Otolaryngology and Dermatology, Washington University, St. Louis, MO

76. 2008 Chole R.A. Osteoclastic bone resorption in Cholesteatomas. Abstract submitted to the

8th International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal of Otology (MJO), Volume 4, Suppl 1.

77. 2008 Chole R.A. Bone resorption in the cholesteatoma: the role of the osteoclast. Abstract

submitted to the 8th International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal of Otology (MJO), Volume 4, Suppl 1.

78. 2008 Chole R.A. Animal models of aural cholesteatoma. Abstract submitted to the 8th

International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal of Otology (MJO), Volume 4, Suppl 1.

79. 2008 Chole R.A. Retraction pockets: etiopathogenesis. Experimental evidence. Abstract

submitted to the 8th International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal of Otology (MJO), Volume 4, Suppl 1.

80. 2008 Chole R.A. Cholesteatoma and microbial biofilms. Abstract submitted to the 8th

International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal of Otology (MJO), Volume 4, Suppl 1.

81. 2008 Chole R.A. The role of Pseudomonas biofilms in the destructive process of aural

cholesteatoma. Abstract submitted to the 8th International Conference on Cholesteatoma and Ear Surgery, Antalya, Turkey, June 15-20, published in The Mediterranean Journal

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of Otology (MJO), Volume 4, Suppl 1. 82. 2012 Chole RA, Gagnon PM, Vogel J. Pseudomonas Aeruginosa virulence factors in infected

cholesteatomas. Abstract submitted to the 35th Annual ARO Midwinter Meeting, February 25-29, Manchester Grand Hyatt Hotel, San Diego, CA.

SCIENTIFIC CONTRIBUTIONS 1. 1993 Photograph contribution to A Colour Atlas and Text of Clinical Medicine, C. D. Forbes

and W. F. Jackson, eds., Wolfe Publishing, England, Chapter 1, p. 12. 2. 2002 Chole RA & Forsen, JM. A Colour Atlas of Ear Disease, B.D. Decker, Inc, 2nd Edition. BOOK REVIEWS 1. 1978 Brower, J. and H. A. Kaplan. Cerebral dural sinuses and their tributaries. Archives of

Otolaryngology 104(3): 181. 2. 1981 Rintelman, W. F., Ed., Hearing assessment. University Park Press, 1979. American

Journal of Otolaryngology 2(4): 365-366. 3. 1982 Fisch, U. Tympanoplasty and stapedectomy: A manual of techniques. George Thieme

Verlag, Stuttgart, New York, 1980. Reviewed in American Journal of Otolaryngology. 4. 1985 D. J. Lim et al., ed. Chole R. A.: Recent advances in otitis media with effusion. St.

Louis, C. V. Mosby Co., 1984. Reviewed in Archives of Otolaryngology 111:563, August. Core Curriculum Courses Human Anatomy 403 Neurosciences Course: "Vestibular System" Neurosciences MS420F: "Hearing Disorders" Hearing Loss – “Introduction to Clinical Otolaryngology” – MS2

Hearing Disorders Course – “Diagnosis of Ear Disease” – Program in Audiology & Communication Sciences (PACS)

INVENTIONS The Oto-Endoscopic Camera (Archives of Otolaryngology 106: 230-231, 1980)

Cartilage Total Ossicular Replacement Prosthesis (Archives of Otolaryngology 108: 560-562, 1982) Co-Developer: Silver Impregnated Silastic Tympanostomy Tube (Xomed-Treace, 1995)

CheckSite Medical System - Patient Safety Wristband, Marker, Deactivation Label for accurate surgical site ID (2004) Nasal Surgical Retractor for Endoscopic Pituitary Surgery (Anspach, 2007)

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SPECIAL TRAINING Certificate of Training - Xomed Audiant Bone Conductor

Central Ear Research Institute, Baptist Medical Center, University of Oklahoma Health Science Center and Oregon Hearing Research Center in conjunction with XOMED, Inc., March 1989