Correlation between Retinopathy of Prematurity and Levels of

Proinflammatory Cytokines

Presented in Trisakti University July 2012I Gusti Agung Ayu Widyarini

030.09.113

Retinopathy of Prematurity in The World

WHO: First cause of blindness in infants in

developed and developing countries

Indonesia: First cause of blindness in preterm

infants

Retinopathy of Prematurity

Vascular disorder of infants with gestational age less than 28 weeks and is accompanied by low birth

weight

1. Shastry BS. Genetic susceptibility to advanced retinopathy of prematurity (ROP). J Biomed Sci 2010; 17:69.

Pathogenesis of ROP

1. Sapieha P, Joyal JS, Rivera JC, Duchemin EK, Sennlaub F, Hardy P, et al. Retinopathy of prematurity: understanding ischemical retinal vasculopathies at an extreme of life. JCI 2010; 120(9): 3022-30.

Fails to limit retinal oxygenation

The regrowth becomes overstated, deregulated, and

misguide

Arrest in vascular development

Stages of ROP

1. Piscitelli. Different stages of retinopathy of prematurity. Accessed in June, 28th 2012. Available at: URL: http://ropmalpractice.com/?page_id=19

Cytokine: The Amazing Protein

1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6 th ed. Philadelphia: Elsevier Saunders; 2007. p. 267-70.

Cytokines are proteins secreted by the cells of innate and adaptive immunity that

mediate many of the functions of these cells,

include hematopoietic cells

Proinflammatory Cytokines in Plasma

1. Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 6 th ed. Philadelphia: Elsevier Saunders; 2007. p. 267-70.

Correlation between ROP and Levels of Proinflammatory Cytokines

1. Lee J, Dammann O. Perinatal infection, inflammation, and retinopathy of prematurity. Seminars in Fetal and Neonatal Medicine 2012: 26-9.

BDNF

IL-1β

TNF-α

IL-8

IL-6

NT-4

IGF-I

Proinflammatory cytokines

VEGF

Studies

Study Year Subjects Duration of Intervention Result

Sood et al 2009

877 preterm neonates with

birth weight 401-1000 gr

21 days

↑ IL-6↑ CRP

↓ TGF-β, BDNF, NT-4

Silveira et al2005

-2007

74 very low birth weight infants 27 months

↑ IL-6↑ IL-8

↑ TNF-α

1. Sood BG, Madan A, Saha S, Schendel D, Thorsen P, Skogstrand K, et al. Perinatal systemic inflammatory response syndrome and retinopathy of prematurity. Pediatric Research 2010; 67(4): 394-400.

2. Silveira RC, Filho JBF, Procianoy RS. Assessment of the contribution of cytokine plasma levels to detect retinopathy of prematurity in very low birth weight infants. IOVS 2011; 52(3): 1297-300.

Conclusion

Retinopathy of prematurity is a vascular disorder that attacks the blood vessels of the retina in infants with

premature birth and low birth weight

There are significant association between retinopathy of prematurity in the inflammatory process that triggers

the secretion of proinflammatory cytokines

Thank You