Alexander III of Macedon (356 –323 BCE), commonly known as Alexander the King of Macedon, a state in northern ancient Greece. Born in Pella in 356 BC, Alexander was tutored by Aristotle until the age of 16. By the age of thirty, he had created one of the largest empires of the ancient world, stretching from the Ionian Sea to the Himalayas. He was undefeated in battle.

Alexander succeeded his father, Philip II of Macedon, to the throne in 336 BC after Philip was assassinated. Upon Philip's death, Alexander inherited a strong kingdom and an experienced army. He had been awarded the generalship of Greece and used this authority to launch his father's military expansion plans. In 334 BC, he invaded the Achaemenid empire, ruled Asia Minor, and began a series of campaigns that lasted ten years. Alexander broke the power of Persia in a series of decisive battles, most notably the battles of Issus and Gaugamela. He subsequently overthrew the Persian King Darius III and conquered the entirety of the Persian Empire. At that point, his empire stretched from the Adriatic Sea to the Indus River.

Seeking to reach the "ends of the world and the Great Outer Sea", he invaded India in 326 BC, but was eventually forced to turn back at the demand of his troops. Alexander died in Babylon in 323 BC, without executing a series of planned campaigns that would have begun with an invasion of Arabia. In the years following his death, a series of civil wars tore his empire apart, resulting in several states ruled by the Diadochi, Alexander's surviving generals and heirs.

The Royal Library of Alexandria, or Ancient Library of Alexandria, in Alexandria, Egypt, was one of the largest and most significant libraries of the ancient world. It flourished under the patronage of the Ptolemaic dynasty and functioned as a major center of scholarship from its construction in the 3rd century BC until the Roman conquest of Egypt in 30 BC. With collections of works, lecture halls, meeting rooms, and gardens, the library was part of a larger research institution called the Musaeum of Alexandria, where many of the most famous thinkers of the ancient world studied.

The library was conceived and opened either during the reign of Ptolemy I Soter (323–283 BC) or during the reign of his son Ptolemy II (283–246 BC). As a symbol of the wealth and power of Egypt, it employed many scribes to borrow books from around the known world, copy them, and return them. Most of the books were kept as papyrus scrolls, and though it is unknown how many such scrolls were housed at any given time, their combined value was incalculable.

The library is famous for having been burned, resulting in the loss of many scrolls and books, and has become a symbol of the destruction of cultural knowledge. Ancient sources differ widely on who is responsible for the destruction and when it occurred. Although there is a mythology of the burning of the Library at Alexandria, the library may have suffered several fires or acts of destruction over many years. Possible occasions for the partial or complete destruction of the Library of Alexandria include a fire set by Julius Caesar in 48 BC, an attack by Aurelian in the 270s AD, the decree of Coptic Pope Theophilus in 391, and the Muslim conquest of Egypt in 642.After the main library was fully destroyed, ancient scholars used a "daughter library" in a temple known as the Serapeum, located in another part of the city. According to Socrates of Constantinople, Pope Theophilus destroyed the Serapeum in 391 AD.

The Septuagint from the Latin word septuaginta (meaning seventy), is a translation of the Hebrew Bible and some related texts into Koine Greek. The title and its Roman numeral acronym "LXX" refer to the legendary seventy Jewish scholars that completed the translation as early as the late 2nd century BCE. As the primary Greek translation of the Old Testament, it is also called the "Greek Old Testament”. This translation is quoted in the New Testament, particularly in the writings of Paul the Apostle, and also by the Apostolic Fathers and later Greek Church Fathers.The traditional story is that Ptolemy II sponsored the translation for use by the many Alexandrian Jews who were not fluent in Hebrew but fluent in Koine Greek, which was the lingua franca of Alexandria, Egypt and the Eastern Mediterranean from the death of Alexander the Great in 323 BCE until the development of Byzantine Greek around 600 CE.

Hypathea 350-415