Agilent 5977 MSD New GC/MSD Introduction Overview .TwisTorr 304 FS Innovation for: ... 3 ways to

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Transcript of Agilent 5977 MSD New GC/MSD Introduction Overview .TwisTorr 304 FS Innovation for: ... 3 ways to

  • Agilent 5977 MSD

    Overview

    New GC/MSD Introduction

    January 2013

    January 15, 2013 1

  • New Agilent 5977 Series GC/MSD

    January 15, 2013 2

    The 5977 is the new Agilent GC/MSD platform and replaces the

    5975C and 5975E systems

    Improves performance with high sensitivity Extractor Ion

    Source

    MassHunter GC/MS Acquisition

    MassHunter and MSD ChemStation data analysis

    Integration of new Agilent Vacuum Pumps brings intelligent

    operation

    Direct Communication between 7890B and 5977A for more

    productivity

  • New Agilent 5977 Series GC/MSD

    What is the same as 5975?

    January 15, 2013 3

    Quality

    Reliability

    Proven core technology since 5973/5975

    Inert Ion Source

    Heatable Gold Quartz Quadrupole

    Triple Axis Detector

    High Energy Diode

    Triple Channel EM Detector

    Productivity Software

    (MSD ChemStation Data Analysis)

  • New Agilent 5977 Series GC/MSD

    January 15, 2013 4

    What is new with 5977?

    Better Performance

    High Sensitive Extractor Ion Source

    Improved Agilent Vacuum Pump

    More Productivity

    Direct Communication 7890B5977A

    Protect system

    Vent the system faster

    Power save (Sleep/Wake)

    MassHunter Software

    Data Acquisition (Method/Sequence)

    Data Analysis

  • New Extractor Ion Source for 5977

    Page 5

    Why the Extractor EI Source?

    Increase in ion count

    True increase in sensitivity

    Better trace level precision

    Lower IDL and MDL

    Proven sensitivity increase demonstrated with

    over 1500 7000 Series GC/TQ!

    January 15, 2013

  • Comparison between Inert Ion Source and

    Extractor Ion Source

    Page 6

    Repeller

    (Push)

    Drawout Plate

    Ion Focus Lens

    Entrance Lens

    Ionization area

    Ions

    Inert Ion Source

    Extractor Lens

    (Pull)

    Extractor Source

    More ions to

    Mass Filter

    Mass Filter

    January 15, 2013

  • How Extractor Ion source with Etune be seen in

    the Chromatogram?

    January 15, 2013 7

    Blue Extractor 40ppb solution (SVOC)

    Red Standard 40ppb solution (SVOC)

  • More improvements on 5977s Extractor Ion Source:

    Improved Thermal Profile

    Page 8

    Why is this important? Better performance of high boilers

    i.e. PAH even at lower concentration!

    10 Injections 80 min analysis

    Good repeatability of

    PAH even at the trace

    level (5ppb)!!

    Improvement for better Mass

    Spectrometer of Gas Chromatograph

    January 15, 2013

  • Sensitivity Specifications of the 5977

    January 15, 2013 9

    Full Scan EI Specification: S/N - Signal-to-Noise

    The 5977 in scan mode has some background noise even if only OFN standard is injected, therefore the traditional Signal-to-Noise (S/N) is used as specification.

    Agilents 5977 has the highest S/N (1500:1) with Extractor Ion Source among the SQ system. (1pg OFN)

    SIM Specification: IDL - Instrument Detection Limit

    Agilent 5977A uses this sensitivity specification for detection

    techniques where no or little noise is generated, such as when OFN standard is injected. IDL is a new specification for SIM, but have been used with MS/MS for over a year.

  • 5977A GC/MSD IDL Specification

    IDL is a statistically derived value from the precision (%RSD) of 8

    consecutive, splitless injections of 100fg OFN at 99 % confidence

    level. The more precise instruments (lower %RSD) will generate lower

    IDLs.

    The Agilent 7890B/5977A with an ALS or CTC autosampler has the

    following specifications:

    January 15, 2013 10

    Ion Source type High Vacuum pump type IDL of OFN by 8 replicates of ALS*

    Extractor Source Turbo Pump 10fg

    Inert Source

    Turbo Pump 24fg

    Diffusion Pump 30fg

    *Systems without an Autosampler will have only S/N specification.

    These are installation specification, performed on customer site, immediately

    after installation and carry a lot more value than a reference specs.

  • Why IDL specification is useful for the 5977 in SIM?

    Influence of Noise in S/N specs

    In SIM (or MS/MS) when the Noise is too low, such as during acquisition of an OFN standard, S/N results may not give the best characterization

    If the noise level is insignificant - varies a lot and too low- the derived value from it (S/N) also becomes insignificant

    Value of IDL

    IDL is derived from reproducibility/precision results, the same metrics most users utilize every day in their work. The IDL statistical process is the same used for Method Detection Limit calculations, and the %RSD values are tools to monitor analytical performance

    IDL characterizes the whole system AS, GC, MS- giving confidence in overall reliability. It is the results of 8 consecutive injections, unlike S/N in a single shut, which can be influenced by many parameters/conditions

    January 15, 2013 11

  • The Influence of the low Noise on S/N values Same Data File, RMS, 5 Second Noise Region

    Noise region: 5.66min - 5.74 min

    S/N: 3335

    Noise region: 5.65min - 5.73 min

    S/N: 10785

    A 0.01 min. shift in the noise region resulted a 6000 higher S/N value.

    When the noise is insignificant (low), the derived S/N value is also insignificant!

    Noise region:

    5.65min-5.73 min

    Noise region:

    5.66min-5.74 min

    S/N S/N

    January 15, 2013 12

  • Better HW Features: Agilent Turbo Pump (V304)

    Page 13

    Agilent Quality Standard

    TwisTorr 304 FS

    Innovation for:

    Higher pumping performance

    especially for He and H2 High reliability

    lower cost of operation

    January 15, 2013

    Press release : http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

    http://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.htmlhttp://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.htmlhttp://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.htmlhttp://www.agilent.com/about/newsroom/presrel/2012/19dec-ca12077.html

  • Better HW Features: Agilent Rough Pumps

    Page 14

    New DS42i New IDP-3c

    High performance

    Energy saving design Inverter mode not active with diff pump

    High performance

    Oil-free scroll pump

    NH3 CI compatible

    with Agilent Quality Standards

    January 15, 2013

  • Better HW Features: Power consumption saving of

    MSD by Inverter Pump (DS42i)

    15

    0

    100

    200

    300

    400

    Operation mode Sleep Mode

    320W

    190W

    What this means to the

    laboratory cost of ownership?

    January 15, 2013

  • Example of Cost simulation of saving power with

    Agilent 7890B/5977A at Environmental Lab

    Assumptions

    GC/MSD cycle time: 40 minutes (30min for data acq./10 min for cool down & prep)

    Sample: 30 samples/day

    Working day: 5 days/week, no operating on Sat/Sun

    GC/MSD wake time = 40 min/sample * 30 samples * 5 days/week

    = 6,000 min/week = 100 hours/week

    = 32 kWh

    GC/MSD sleep time = 168 hours/week 100 hours/week = 68 hours/week

    = 13 kWh

    Total Power usage (1 week) = 45 kWh (with Sleep mode)

    Total Power Usage (1 week) = 54 kWh (without Sleep mode

    Weekly MS Power saving per instrument = 9kWh (17%)

    January 15, 2013 16

  • 3 ways to go to Sleep mode

    January 15, 2013 17

    From the Sequence Keyword

    From the menu item of

    MassHunter

    From the 7890B Keypad

  • Key features of Direct Communication between

    7890B and 5977A

    Page 18

    Sleep/Wake mode

    In sleep mode, MSD will go to the Power save mode (320W 190W)

    Laboratory Operating Cost Reduction (see the previous slide for detail)

    Safety Control

    If 5977A MSD Pumps fail, 7890B will shut off the gas supply for protecting

    GC/MSD system.

    Cool Down MSD Faster (FastVent)

    When MSD Vent Cycle started, GC will cool down MSD analyzer at the

    optimum gas flow to MSD.

    Helium Carrier gas : This prevents wasting gas.

    Hydrogen Carrier gas: This reduces the risk of explosion in MSD.

    Less time to wait for cooling down MSD analyzer (40 min 25 min when cooling

    down from 280C to 100C)

    January 15, 2013

  • MassHunter GC/MS Acquisition for GC/MSD

    Unified GC/MS Acquisition and

    MassHunter Data Analysis; with MSD ChemStation workflow for GC/MSD

    January 15, 2013 19

  • GC/MSD Software

    January 15, 2013 20

    MassHunter Qual

    MassHunter Quant MH

    CS

    MassHunter GC/MS Acquisition

    And Use Either

    MassHunter Data Analysis

    OR

    MSD ChemStation Data Analysis MSD ChemStation DA

    G1701FA

  • The Value of G1701FA Software

    All Inclusive G1701FA Software Package

    MassHunter GC/MS Acquisition

    MassHunter Quantitative Analysis

    MassHunter Qualitative Analysis

    MSD ChemStation Data Analysis

    21CFR11 Compliance tools (Acquisition and

    MH Quantitative Analysis)

    GC/MS and LC/MS Translators

    Collated User Information

    Workflow guides, Video Tutorials, all in one

    location

    Support

    1yr Upgrade, Updates, and Phone Support