Sarcoidosis

Sarcoidosis (from sarc meaning flesh, -oid, like, and -osis, process), also called sarcoid,Besnier-Boeck disease or Besnier-Boeck-Schaumann disease, is a disease in which abnormal collections of chronic inflammatory cells (granulomas) form as nodules in multiple organs. The cause of sarcoidosis is unknown. Granulomas most often appear in the lungs or the lymph nodes, but virtually any organ can be affected. Normally the onset is gradual. Sarcoidosis may be asymptomatic or chronic. It commonly improves or clears up spontaneously. More than 2/3 of people with lung sarcoidosis have no symptoms after 9 years. About 50% have relapses. About 10% develop serious disability. Lung scarring or infection may

lead to respiratory failure and death.

Classification of sarcoidosis

Sarcoidosis may be divided into the following types:

Annular sarcoidosis

Erythrodermic sarcoidosis

Ichthyosiform sarcoidosis

Hypopigmented sarcoidosis

Löfgren syndrome

Lupus pernio

Morpheaform sarcoidosis

Mucosal sarcoidosis

Neurosarcoidosis

Papular sarcoid

Scar sarcoid

Subcutaneous sarcoidosis

Systemic sarcoidosis

Ulcerative sarcoidosis

The most related to polyuria is sarcoidosis type neurosarcoidosis, condition of

unknown cause featuring granulomas in various tissues, involving the central nervous

system(brain and spinal cord). It can have many manifestations, but abnormalities of the cranial

nerves are the most common. 

The sign and symptom which related to endocrine is Granulomas in the pituitary gland,

which produces numerous hormones, is rare but leads to any of the symptoms

of hypopituitarism:amenorrhoea (cessation of the menstrual cycle), diabetes

insipidus (dehydration due to inability to concentrate the urine), hypothyroidism(decreased

activity of the thyroid) or hypocortisolism (deficiency of cortisol).

Due to cases,polyuria that occur in neurosarcoidosis is because of diabetes

insipidus but also accompanied by other sign and symptoms.