Sarcoidosis
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Sarcoidosis
Sarcoidosis (from sarc meaning flesh, -oid, like, and -osis, process), also called sarcoid,Besnier-Boeck disease or Besnier-Boeck-Schaumann disease, is a disease in which abnormal collections of chronic inflammatory cells (granulomas) form as nodules in multiple organs. The cause of sarcoidosis is unknown. Granulomas most often appear in the lungs or the lymph nodes, but virtually any organ can be affected. Normally the onset is gradual. Sarcoidosis may be asymptomatic or chronic. It commonly improves or clears up spontaneously. More than 2/3 of people with lung sarcoidosis have no symptoms after 9 years. About 50% have relapses. About 10% develop serious disability. Lung scarring or infection may
lead to respiratory failure and death.
Classification of sarcoidosis
Sarcoidosis may be divided into the following types:
Annular sarcoidosis
Erythrodermic sarcoidosis
Ichthyosiform sarcoidosis
Hypopigmented sarcoidosis
Löfgren syndrome
Lupus pernio
Morpheaform sarcoidosis
Mucosal sarcoidosis
Neurosarcoidosis
Papular sarcoid
Scar sarcoid
Subcutaneous sarcoidosis
Systemic sarcoidosis
Ulcerative sarcoidosis
The most related to polyuria is sarcoidosis type neurosarcoidosis, condition of
unknown cause featuring granulomas in various tissues, involving the central nervous
system(brain and spinal cord). It can have many manifestations, but abnormalities of the cranial
nerves are the most common.
The sign and symptom which related to endocrine is Granulomas in the pituitary gland,
which produces numerous hormones, is rare but leads to any of the symptoms
of hypopituitarism:amenorrhoea (cessation of the menstrual cycle), diabetes
insipidus (dehydration due to inability to concentrate the urine), hypothyroidism(decreased
activity of the thyroid) or hypocortisolism (deficiency of cortisol).
Due to cases,polyuria that occur in neurosarcoidosis is because of diabetes
insipidus but also accompanied by other sign and symptoms.