Post on 03-Jan-2016
description
Incest and folk-dancing ….
Steve Jones 2001 Pan Pacific
Bodybuilding Champion
Steve jones
Elephant seal
Testosterone Molecule
M-f mortality
Female anglerfish and her partners
The Y
MaleMale
Thames at Westminster
Thames near Source
Drosophila bifurca – testis, the single sperm, and a standard of comparison
The Apocalypse according to William Blake
The city of Megiddo – the biblical Armageddon
Armageddon
THE ARITHMETIC OF ARMAGEDDON – 722 BC
2, 4, 8, 16, 32 …… fifty times: comes to
100,000,000,000,000,(a hundred million million) supposed ancestors.
At a generous guess the real number of people then was 100,000,000 (a hundred million).
Ie not enough ancestors - which means SHARED ANCESTRY AND UNIVERSAL INBREEDING!
Present
Time
22 individuals
18 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
3 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
3 ancestors
3 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
3 ancestors
3 ancestors
2 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
3 ancestors
3 ancestors
2 ancestors
2 ancestors
Present
Time
22 individuals
18 ancestors
16 ancestors
14 ancestors
12 ancestors
9 ancestors
8 ancestors
8 ancestors
7 ancestors
7 ancestors
5 ancestors
5 ancestors
3 ancestors
3 ancestors
3 ancestors
2 ancestors
2 ancestors
1 ancestor
Present
Time
Present
Time
Most recent common ancestor(MRCA)
Inbreedign euro royalty
Serious inbreeding among European Royals (max at 7 generations = 128 ancestors)Generations 4 5 6 7 Ift de Espana (1901-1964) 8 12 12 12
Gottfried of Tuscany (1901-) 8 10 15 18
Alfonso XII King of Spain (1857-1885) 4 4 6 8
Francesco, Duke of Marchena (1861-1923) 2 4 8 8
Maria Antonia of Austria (1669-1692) 4 4 6 10
Louis XV King of France (1710-1774) 4 8 12 16
Tutankhamun’s pedigree - incest
Feet of an inbred God - Tutankhamun
3000 lines of descent 4000 lines of descent
Inbred – identity by descent
Charles Darwin’s cousin marriage
The Bulldog in 1817
The Bulldog in 2008
Rare surnames (Attenborough but not Smith) share a Y chromosome
Consang marriage rates ww
Finnish genetic disease
VLINCL pedigrees in Finland
Inbreeding loops in Finland
Likely world colonisation routes, and genetic distance from E Africa (shades of green)
Extent of diversity against distance to Addis Ababa – lowest in Americas
Runs of homozygosity – shared names, and shared lengths of DNA
attenboroughattenborough
agccccttaattaagccccttaatta
Inbreeding in Croatia
Runs of homozygosity of different lengths, island and mainland
Close correlation between inbreeding as measured from pedigrees and from runs of homozygosity
Runs of homozygosity: more inbreeding in hunter-gatherers than farmers
Runs of homozygosity (green blocks) in boy with multiple medical problems. May be son of incestuous relationship
The locations of the identified IBD segments (black horizontal bars) among the genomes of the colon cancer patients and the control data sets.
Runs of homozygosity and schizophrenia: odds increase by 17% for every 1% increase in genome-wide autozygosity.
ROH in Early Onset Parkinson’s Disease; cases blue controls red. Black line – ratio.
Increase in infection rates with inbreeding
Sex and the 747 – American flight patterns
Decline in US runs of homozygosity (inbreeding) with birth date from 1900 to 2000
Jones in 1881
Jones in 1998
Fig. 1 Language locations and regional variation in phonemic diversity – bottlenecks on the way across the world.
Q D Atkinson Science 2011;332:346-349
Published by AAAS
Outbred and inbred slug populations
Oxfordshire (left); Skye (right)