Hormon Feedback Regulation of the Anterior Pituitary: Target Organ Hypothalamus + - + - - - ? Short Loop Feedback Pituitary Long Loop Feedback negative feedback :

secretion of hormoneleads directly or indirectlyto inhibiting its secretion

positive feedback: secretion of hormone leads directly or indirectly to its increase secretion

Hormon - Subunits

- Subunit TSH LH hCG FSH

Hormon

Congenital Hypothyroidism Cretinism Stunted growth

Neurological/cognitivedefects/mentalretardation