Water soluble vitamins Folic acid ppt Lecure 2 BIOICHEMISTRY [email protected]
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Transcript of Water soluble vitamins Folic acid ppt Lecure 2 BIOICHEMISTRY [email protected]
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WATER SOLUBLE VITAMINS
Dr Vijay Marakala MBBS.,MD
Assistant ProfessorBIOCHEMISTRY
SIMS & RC
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FOLIC ACID
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Folic acid consist of pteridine nucleus, p-aminobenzoic acid and glutamate .
•CHEMISTRYFOLIC ACID
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FOLIC ACID SOURCES
Green leafy vegetables
PulsesEggsLiver
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Daily Requirement (RDA)
200μg/day
FOLIC ACID RDA
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ABSORPTION AND TRANSPORT
Polyglutamate form converted to monoglutamate form
After cellular uptake converted to THF
FOLIC ACID
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ACTIVE FORM Tetrahydrofolate [THF]
FOLIC ACID
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•FOLIC ACID -FUNCTIONS
One carbon metabolism
THF is required for cell division.
↓Plasma Homocysteine
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One carbon compounds
CH3
CH2
CHCHO
CO2
One carbon groups can be transferred from one compound to another
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One carbon metabolism
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FOLIC ACID
DHF
THF
N5-Methyl-THF
N5,N10-Methylene THF N5Formyl-THF
Homocysteine
Methionine FIGLU
HISTIDINE
GLUTAMATE
Serine Glycine dUMP
TMP
DNA
Methyl VitB12
Purine
DNARNA
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FOLIC ACID-Deficiency Megaloblastic anaemia
Neural tube defects in fetus
Hyperhomocysteinemia
Accumulation and excretion of FIGLU in urine
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Normal marrow Megaloblastic marrow
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FOLATE TRAP THEORY
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•FOLIC ACID ANTAGONISTS
Sulfonamides
Methotrexate
Pyrimethamine
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