Vitiligo - Mahidol · •When mucosal vitiligo occurs in the context of NSV, it is classified as...
Transcript of Vitiligo - Mahidol · •When mucosal vitiligo occurs in the context of NSV, it is classified as...
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Vitiligo
Vasanop Vachiramon, MD.
Assistant professor
Division of Dermatology, Ramathibodi Hospital
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Vitiligo
• Acquired pigmentary disorder
• Depigmented macules and patches
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Prevalence
• The worldwide prevalence of vitiligo is up
to ~2%
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Clinical manifestations
• Asymptomatic depigmented patches and macules
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Island of normal skin
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Wood’s light
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Clinical manifestations
• Koebner’s phenomenon (the development of lesions at sites of specifically traumatized uninvolved skin of patients with cutaneous diseases)
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Classification of vitiligo
• Segmental vitiligo
• Non-segmental vitiligo
• Unclassified: mucosal, focal
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Segmental vitiligo
• Mono-segmental vitiligo: most common
• Bi-segmental vitiligo
• Plurisegmental vitiligo
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Non-segmental vitiligo
• Typically evolves over time (distribution, extension) often involving both sides of the body with tendency toward symmetrical distribution -acrofacial (face, head, hands, feet) -generalized -universal: 80-90% of BSA -mixed vitiligo: initial SV followed by
bilateral NSV patches
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NSV (Generalized vitiligo)
• Face: periorbital, perioral
• Trunk, axilla, groin, umbilicus
• Extremity: elbow, wrist, hand, feet
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Unclassified: mucosal vitiligo
• An isolate involvement of oral and/ or genital mucosa for at least 2 years F/U
• When mucosal vitiligo occurs in the context of NSV, it is classified as NSV
• Differential diagnosis: lichen sclerosus
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Unclassified: focal vitiligo
• Acquired, small, isolated depigmented lesion that does not fit a typical segmental distribution and has not evolved into NSV after a period of 2 yr
• The diagnosis should be considered only after having ruled out all other diagnoses, and a biopsy may be helpful
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Focal Segmental Generalized Universal
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Pathogenesis
• Autoimmune: best supported theory
• Neurohumoral: segmental vitiligo
• Oxidative stress
• Melanocytorrhagy
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Vitiligo and autoimmune diseases
• Patients with generalized vitiligo, especially when familial, are more likely to have autoimmune disorders than those with SV
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Common associations
J Am Acad Dermatol 2011; 65: 473-91.
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Autoimmune thyroid disease (ATD)
• Median prevalence of ATD in vitiligo -children: 6.89% (5.79-12.7%) -adult: 18.6% (13.7-22.9%)
• The risk of ATD in vitiligo patients seems to increase with age
Br J Dermatol 2012; 167: 1224-35.
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Less common associations
J Am Acad Dermatol 2011; 65: 473-91.
ANA is positive in up to 12.4% of patients
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Recommendations
• TSH
• ANA
• Thyroid antibodies: can present up to 7 years before clinical diagnosis of autoimmune thyroid diseases
J Am Acad Dermatol 2011; 65: 473-91.
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Neurohumoral hypothesis
• Melanocytes and nerves arise from neural crest cells
• Lesions may also exhibit increased levels of NE and decrease AchE
• Alteration in neurotransmitters may cause -melanocyte cytotoxicity -vasoconstriction, cell hypoxia
Arch Dermatol Res 1996; 288: 14-8. Acta Anat 1989; 136: 139-41.
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Differential diagnosis
• Depigmented lesion -nevus depigmentosus -chemical leukoderma -postinflammatory depigmentation -lichen sclerosus -idiopathic guttate hypomelanosis -vitiligo-like DLE
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Nevus depigmentosus
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Chemical leukoderma: hydroquinone
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Postinflammatory depigmentation in severe atopic dermatitis
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DLE
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Lichen sclerosus
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Idiopathic guttate hypomelanosis
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Halo nevus
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Nevus anemicus
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Differential diagnosis
• Hypopigmented lesion -pityriasis alba -pityriasis versicolor -postinflammatory hypopigmentation -hypopigmented mycosis fungoides -progressive macular hypomelanosis -tuberculoid leprosy -Ash-leaf hypomelanotic macule
(tuberous sclerosis)
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Pityriasis alba
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Pityriasis versicolor
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Postinflammatory hypopigmentation
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Tuberculoid leprosy
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Ash leaf macule
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Management
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Topical corticosteroids (TCS)
• Up to 75% repigmentation on face and neck, in dark skin, and recent lesions
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Adverse effects of topical steroids
• Atrophy • Telangiectasia • Purpura, easy bruising • Striae • Acne • Hypertrichosis • Glaucoma • Cataract • Etc.
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TCS: recommendations
• Application of potent TCS is advised to limited, extra-facial lesion for -3 months (everyday) or -6 months (15 days/month)
• Large area of skin, thin skin, children: momethasone furoate is preferred
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Topical immunomodulators (TIM) • Tacrolimus, pimecrolimus
• Alternative to TCS for lesions on thin skin
• Results similar to TCS with fewer side effects
• Occlusion enhance the effect
• TIM enhance the efficacy of phototherapy
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TIM: recommendations
• TIM should be restricted to face and neck region
• Twice daily applications are recommended
• The treatment should be prescribed initially for 6 months. If effective, treatment longer than 12 months may be proposed
• During the period of treatment, moderate but daily sun exposure is recommended
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Narrowband UVB and targeted phototherapy
• NUVB -mean repigmentation is 41-68% from 3-6 mths -a gold standard for the treatment of vitiligo
• Targeted phototherapy -for small/ localized lesion -2-3 times/week
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NUVB and targeted phototherapy: recommendations
• Total NUVB is indicated for generalized NSV (>15-20% BSA involvement)
• Targeted phototherapy is indicated for -small lesion -all cases where C/I exist for total NUVB
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NUVB and skin cancer
• NUVB does NOT significantly increase risk of NMSC compared with the general population
J Am Acad Dermatol 2012; 66: 326-7.
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Other systemic treatments
• Current data do not provide enough evidence to recommend systemic corticosteroids, immunosuppressants or biologics in vitiligo
Br J Dermatol 2013; 168: 5-19.
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Surgery: recommendations
• Surgery should be preserved for SV, localized vitiligo, after failure of other treatments
• For NSV, stable disease and KP negative are eligible
Br J Dermatol 2013; 168: 5-19.
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Vitiligo surgery
• Tissue graft -punch graft -suction blister graft
• Cellular graft -non-cultured epidermal cell suspension -melanocyte culture
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Treatment algorithm
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SV
-avoidance triggering factors -TCS, TIM
No therapy Phototherapy
Camouflage Surgery
repigmentation progression
repigmentation
No repigmentation KP+ KP-
Br J Dermatol 2013; 168: 5-19.
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NSV
-avoidance triggering factors
-TCS, TIM, NUVB for 3 mths -Camouflage
NUVB 9 months Immunosuppressants?
Camouflage Depigmentation
Surgery
repigmentation progression
repigmentation
No repigmentation KP+ KP-
Br J Dermatol 2013; 168: 5-19.
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Q & A
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Melasma ผศ.นพ.วาสนภ วชิรมน
หน่วยโรคผิวหนงั ภาควิชาอายรุศาสตร์
คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี
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Melasma
• Acquired pigmentary disorder
• Symmetrical hyperpigmented patches and macules, especially the forehead, malar area, and chin
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Epidemiology
• The reported prevalence of melasma ranges from 8.8% among latino females to 40% in SE populations
• Onset: 20⁺-40⁺ YO
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Differential diagnosis
• Postinflammatory hyperpigmentation
• Nevus of Hori
• Becker melanosis
• Drug induced hyperpigmentation: minocycline, phenytoin, clofazimine
• Solar lentigo
• Acanthosis nigricans • Lichen planus actinicus
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Postinflammatory hyperpigmentation 2 ̊to acute cutaneous LE
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Nevus of Hori
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Becker melanosis
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Drug-induced hyperpigmentation
Minocycline Clofazimine
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Acanthosis nigricans
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Solar lentigo
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Pathogenesis
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Genetic predisposition
• A positive family history of melasma were found in 10% -70% of study subjects
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Hormone
• Many patients note the onset or worsening of disease with pregnancy or OCP use: estrogen, progesterone
• Thyroid hormone??
• LH??
• ACTH, MSH??
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UV light
• UV radiation stimulate the production of multiple cytokines (e.g., IL-1, ET-1, α-MSH, ACTH, SCF, GRO-α, GM-CSF, PGE2) from keratinocytes which upregulate melanocyte proliferation and melanogenesis
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Treatment
• Before melanin synthesis e.g., UV block, cytokine inhibitors, receptor blocking agents, tyrosinase transcription
• During melanin synthesis e.g., enzyme inhibition (e.g., tyrosinase)
• After melanin synthesis e.g., inhibition of melanosome transfer, increase skin turnover
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Patient education
• Sun avoidance
• Patients who develop melasma while using hormonal contraception should stop the medication
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Sunscreen
• A regular use of broad spectrum sunscreen is effective both in preventing melasma and in enhancing the efficacy of topical therapies for melasma
• A broad spectrum UVA- and UVB-protective sunscreen with an SPF of at least 30 along with a physical block (e.g., titanium dioxide or zinc oxide) should be used and reapplied frequently
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Topical treatment: first line
• Hydroquinone: tyrosinase inhibition
• Retinoids: inhibit tyrosinase transcription, ↑cell turnover, ↓melanosome transfer
• Triple combination: hydroquinone, retinoids, steroids
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Topical treatment: adjunctive
• Azelaic acid
• Kojic acid
• Arbutin
• Ascorbic acid
• Licorice extract
• Soy
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Chemical peels
• Glycolic acid may be the most efficacious
peeling agent for melasma, but it should be used cautiously
• Glycolic acid peels should be used in conjunction with a depigmenting agent for maximal benefit and to minimize the risk of
postinflammatory hyperpigmentation
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Laser and light
• Laser and light therapy (e.g., fractional laser, IPL) may also provide modest benefit as an adjunctive treatment in a select population of patients, but larger studies are needed before this therapy can be widely recommended
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Q & A