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Serrated polypsColorectal carcinogenesis and clinical implicationsIJspeert, J.E.G.

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Citation for published version (APA):IJspeert, J. E. G. (2017). Serrated polyps: Colorectal carcinogenesis and clinical implications.

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Joep IJspeert

UITNODIGING

Voor het bijwonen van deopenbare verdediging van het

proefschrift

SERRATED POLYPScolorectal carcinogenesis and

clinical implications

door

Joep IJspeert

op vrijdag 27 januari 2017om 14.00 uur

in de Agnietenkapel van deUniversiteit van Amsterdam,

Oudezijds Voorburgwal 229-231te Amsterdam

Paranimfen

Taco Zwarttczwart@hotmail.com

Jan Louwerensjanlouwerens@gmail.com

Joep IJspeert

Alexanderkade 1-II1018 CH Amsterdam

j.e.ijspeert@amc.uva.nl

0621392201

S E R R AT E D P O LY P Scolorectal carcinogenesis and

clinical implications

SER

RA

TE

D P

OLY

PS colorectal carcinogenesis and clinical im

plications Joep IJspeert

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SERRATED POLYPScolorectal carcinogenesis and clinical implications

Joep IJspeert

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ISBN: 978-94-028-0452-2

Cover: Mathiole

Lay-out: Ilse Stronks, persoonlijkproefschrift.nl

Printed: Ipskamp Printing

The printing of this thesis was financially supported by: the Academic Medical Centre Amsterdam,

Stichting Wetenschap en Onderzoek Interne Geneeskunde OLVG, Nederlandse Vereniging voor

Gastroenterologie, Zambon Nederland B.V., Yakult Nederland B.V., Olympus Nederland B.V., Dr. Falk

Pharma Benelux B.V., ChipSoft, US Endoscopy, Norgine, PENTAX Nederland B.V.

Financial friends of this thesis: Jet Gerards, Peter IJspeert, Ron van der Heijden, Taco Zwart

Copyright © 2016 Joep Evert Godfried IJspeert. All rights are reserved. No part of this thesis may be

reproduced or transmitted in any form or by any means without the prior permission in writing of

the author

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SERRATED POLYPScolorectal carcinogenesis and clinical implications

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie,

in het openbaar te verdedigen in de Agnietenkapel

op vrijdag 27 januari 2017, te 14.00 uur

door

Joep Evert Godfried IJspeert

geboren te Groningen

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Promotiecommissie

Promotores prof. dr. E. Dekker Universiteit van Amsterdam

prof. dr. P. Fockens Universiteit van Amsterdam

Overige leden dr. F. Balaguer Prunés University of Barcelona

prof. dr. W.A. Bemelman Universiteit van Amsterdam

prof. dr. J.C.H. Hardwick Universiteit Leiden

prof. dr. A.A.M. Masclee Universiteit Maastricht

prof. dr. J.P. Medema Universiteit van Amsterdam

prof. dr. C.J.M. van Noesel Universiteit van Amsterdam

Faculteit der Geneeskunde

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TAbLE Of cOnTEnTS

General introduction and outline of this thesis 9

Chapter 1 Serrated neoplasia—role in colorectal carcinogenesis and clinical

implications

Nature Reviews Gastroenterology and Hepatology 2015

15

Chapter 2 Clinical, histological and molecular features of sessile serrated polyps

caught in the act of malignant progression

35

Chapter 3 Detection rate of serrated polyps and serrated polyposis syndrome in

colorectal cancer screening cohorts; A European overview

Gut 2016

51

Chapter 4 Prevalence, distribution and risk of sessile serrated adenomas/polyps in

a centre with a high adenoma detection rate and experienced

gastrointestinal pathologists

Endoscopy 2016

67

Chapter 5 CT-colonography versus colonoscopy for detection of high-risk sessile

serrated polyps

American Journal of Gastroenterology 2016

83

Chapter 6 Smoking status informs about the risk of advanced serrated polyps in a

screening population

Endoscopy International Open 2015

97

Chapter 7 The proximal serrated polyp detection rate is an easy to measure proxy

for the detection rate of clinically relevant serrated polyps

Gastrointestinal Endoscopy 2015

111

Chapter 8 Optical diagnosis of sessile serrated polyps: bottleneck for the optical

diagnosis paradigm?

Journal of Clinical Gastroenterology 2016

125

Chapter 9 Development and validation of the WASP-classification system for optical

diagnosis of adenomas, hyperplastic polyps and sessile serrated polyps

Gut 2015

141

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Chapter 10 Implementation of an e-learning improves the consistency in the

histopathological diagnosis of sessile serrated lesions within a

nationwide population screening program

Submitted

157

Chapter 11 Serrated polyposis syndrome; a silent killer when undetected

Endoscopy 2015

171

Chapter 12 Clinical risk factors of colorectal cancer in patients with serrated

polyposis syndrome: a multicentre cohort analysis

Gut 2015

177

Chapter 13 Thesis summary and future prospects 193

Appendix Nederlandse samenvatting voor niet-ingewijden

Contributing authors

List of publications

PhD portfolio

About the author

Dankwoord

Stellingen

205

213

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220

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