UPMC Western Psychiatric Hospital 

Comprehensive Recovery Services 

Research Studies 

 

1. Shaun Eack, PhD 

a. Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES) 

2. Fabio Ferrarelli, MD 

a. Natural Oscillatory Reduction of DLPFC in Early Course Schizophrenia: A 

TMS/EEG Study (NORDECS) 

3. Danella Hafeman, MD, PhD 

a. Brain Regulation of Emotions and Thoughts (BREATHE ‐ SMART)  

b. Brain, Emotions, and Mindfulness in Young Teens at Risk for Mood Disorders 

(Virtual BEaM) 

4. Leslie Horton, PhD 

a. Youth Emotions, Thoughts, and Interactions (YETI) Phone Study 

b. Psychosis Risk Outcomes Network (ProNET) 

5. Vishwajit L. Nimgaonkar, MD, PhD 

a. Cromoglicate Adjunctive Therapy for Outpatients with Schizophrenia (CATOS) 

6. Konasale Prasad, MD 

a. Genetics & Neuroimaging of Early Onset Schizophrenia (GENEOS) 

7. Dean Salisbury, PhD 

a. Pathology and Pathophysiology in Early Psychosis 

8. Deepak Sarpal, MD 

a. A Multidimensional Dissection of Antipsychotic Treatment Response in Early 

Schizophrenia (DARES) 

   

Shaun Eack, PhD

Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

Help for Adults with Schizophrenia and Negative Symptoms

PACES

Negative symptoms of

schizophrenia can limit your

quality of life. The PACES

program is exploring

interventions to help you better

manage stress, and understand

social interactions.

P A C E S : P r o m o t i n g

A c t i v i t y a n d

C o g n i t i v e

E n r i c h m e n t i n

S c h i z o p h r e n i a

Western Psychiatric Institute and Clinic

Webster Hall

4415 Fifth Avenue

Suite 142M

Pittsburgh, PA 15213

Phone: 412-246-5485

E-mail: hogartyss@upmc.edu

PACES is a treatment study for people

diagnosed with schizophrenia or

schizoaffective disorder and negative

symptoms.

Common negative symptoms include:

Low Motivation

Difficulty getting started and completing activities

Reduced interest/pleasure

Saying very little about things

Social withdrawal

Participants will be treated for up to 18

months with either Cognitive Enhancement

Therapy or Enriched Supportive Therapy;

both of which have been shown to help

people with schizophrenia.

In addition to receiving these research

interventions, participants will also be

asked to complete interviews and

computer testing. Participants will be

compensated for completing these

assessment activities, and will not be billed

for treatment provided by the study.

What is Cognitive Enhancement Therapy

This research intervention aims to help with

problems in thinking, planning, and

socialization. Participants begin with

neurocognitive training using computer

software programs. They also participate in a

small social-cognitive group to learn about

their condition and how to act wisely in social

situations by developing the abilities needed

to understand another person’s perspective,

evaluate social contexts, and be foresightful.

Time commitment: about 3 1/2 hours per week

What is Enriched Supportive Therapy

This research intervention uses individual

supportive therapy to help adults learn about

their condition, manage their emotions and

stress, improve their social skills, and cope

with everyday problems. Participants learn

about the impact of stress on their lives, how

to identify their own early cues of distress, and

apply effective coping strategies to manage

their illness. They also participate in a monthly

support group.

Time commitment: about 1 hour per week plus 1 hour per month

Who is Eligible to Participate

Individuals with the following characteristics may

be eligible for the PACES program:

Age 18-50

Diagnosis of schizophrenia or schizoaffective

disorder

Persistent negative symptoms

Taking prescribed antipsychotic medication

No diagnosis or history of seizures, head

trauma or mental disability

No drug or alcohol abuse

Ability to speak and read English

Is There a Charge to Participate?

There is no charge for any of the research

procedures, including Cognitive Enhancement

Therapy and Enriched Supportive Therapy

appointments. Financial reimbursement for

travel to the clinic is available and participants

could earn up to $825.00 for completing the

study.

PACES (Promoting Activity and

Cognitive Enrichment in Schizophrenia)

Fabio Ferrarelli, MD

Natural Oscillatory Reduction of DLPFC in Early Course Schizophrenia: A TMS/EEG Study (NORDECS)

NORDECS Have you recently started experiencing psychotic symptoms, such as hallucinations,

paranoia, or confusing thoughts and disorganization?

The Natural Frequency Study is a research study at the University of Pittsburgh and UPMC Western Psychiatric.

This study is recruiting individuals between the ages of 18 and 40 who have been diagnosed with schizophrenia, schizophreniform, or schizoaffective disorder within the last 2 years.

After completing screening procedures to confirm eligibility, participants will undergo the

following procedures as part of this study:

Clinical and diagnostic interviews MRI scans

Neuropsychological testing Transcranial Magnetic Stimulation (TMS) & EEG recordings

Participants will be compensated. There is no cost for participation.

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Danella Hafeman, MD, PhD 

 

Brain Regulation of Emotions and Thoughts  

(BREATHE ‐ SMART) 

   

BREATHE-SMARTResearch Study

What is the Smiling

Mind App?

The Smiling Mind App

is an Australian based

application developed

by psychologists and

educators to help bring

balance to your life.

Just as we eat well and

stay fit to keep our

body healthy,

mindfulness meditation

is about mental health

and looking after the

mind.

Mindfulness means

paying attention in a

particular way; On

purpose, in the

present moment, and

non-judgmentally.”

Jon Kabat-Zinn

Research Study Purpose

We would like to test:

• How brain function is related to risk for

bipolar disorder.

• Whether four weeks of regular

mindfulness practice can change brain

function and mood symptoms.

Your child will be compensated for:

• All visits, including initial assessment

• Brain Scans

• Each day your child uses the Smiling

Mind app for at least 5 minutes.

What does the study

involve?

Will my child be

compensated for his/her

time?

To find out if you and your

child are eligible, scan the

code below to complete

the screening form!

Who can participate?

We are looking for children between 10

and 15 years old who have:

• A parent or sibling with bipolar disorder

• Access to a smartphone daily

Children who already have been

diagnosed with bipolar disorder or have

braces cannot participate.

Initial Assessment (1-2 hours)

• You and your child will be asked questions

via video chat about his/her current and

past psychiatric symptoms.

Brain Scans: Two Visits (2-3 hours)

• Actual scan will take about 1 hour.

• You and your child will also complete

questionnaires about mood and anxiety.

Intro and Booster Sessions (1 hour)

• Group sessions will be held via video

chat.

• Online sessions will focus on

mindfulness and the use of the Smiling

Mind App.

.Smiling Mind App (5-10 minutes daily)

• Your child will listen to guided

meditations on the app for at least 5

minutes daily, for 4 weeks.

Two-Month Follow-up (1-2 hours)

• You and your child will complete several

questionnaires regarding his/her anxiety

and mood since discontinuing use of the

Smiling Mind App.

What does the study involve?• At least one assessment of mood symptoms• Questionnaires online• At least one MRI scan• OPTIONAL: 4-week Daily Mindfulness App

If so, your child may qualify for the Brain Regulation of Emotions and Thoughts (BREATHE) Research Study!

Have you been diagnosed with bipolar disorder?AND

Do you have a child 10-15 years old?

Your child will be compensated for

participation

We are looking for children who:• Have a parent or sibling with bipolar disorder• Have not been diagnosed with bipolar disorder• Do not have braces

For more details, and to see if your child qualifies:TEXT “BREATHE Study" to 412-999-2758 or scan the code to

complete the online screening:

Danella Hafeman, MD, PhD

Brain, Emotions, and Mindfulness in Young Teens at Risk for Mood Disorders (Virtual BEaM)

Virtual BEaM Research Study

Brain, Emotions, and Mindfulness in Young Teens at Risk for Mood Disorders

Mindfulness means

paying attention in a

particular way; On

purpose, in the

present moment, and

non-judgmentally.”

Jon Kabat-Zinn

Research Study Purpose

We would like to test:

(1) How well a virtual mindfulness

group works in adolescents with

mood swings.

(2) How mindfulness affects thoughts

and emotions.

Mindfulness Group

• Your child will be asked to attend a

weekly mindfulness group via HIPAA

compliant videoconferencing, lasting

60-90 minutes, for eight weeks.

• This group is designed to help your

child pay more attention to the present

moment, in a non-judgmental way.

Your child will be compensated for:

• Initial assessment & Three-month

follow-up

• Completing questionnaires &

behavioral tasks

What does the study

involve?

Will my child be

compensated for his/her

time?

To find out if you and your

child are eligible, scan the

code below to complete

the screening form!

Who can participate?

We are looking for children 11-14 years

old who have:

• A parent or sibling with major

depressive disorder or bipolar disorder

• Frequent mood swings

Children who already have been

diagnosed with major depressive disorder

or bipolar disorder cannot participate.

Initial Assessment (1-2 hours)

• You and your child will be asked

questions about his/her current and

past psychiatric symptoms via HIPAA

compliant videoconferencing.

Three-month Follow-Up (1-2 hours)

• You and your child will complete

questionnaires about mood and

anxiety.

“Mindfulness is a way

of befriending

ourselves and our

experience.”

Jon Kabat-Zinn

What does this research study involve?• Participating in an 8-week long mindfulness

group via HIPAA-compliant videochat• Completing questionnaires about mood,

anxiety, and mindfulness

We are looking for children who are:• Have a parent or sibling with bipolar

disorder or major depressive disorder• Have mood swings, but have not been

diagnosed with bipolar disorder or major depressive disorder

Have you been diagnosed with bipolar disorder or major depressive disorder?

ANDDo you have a child ages 11-14 years old with mood swings?

For more details, and to see if your child qualifies:TEXT "BEAM study" to 412-999-2758 or scan the code to

complete the online screening:

Your child will be compensated for

their time.

 

 

Leslie Horton, PhD 

 

Youth Emotions, Thoughts, and Interactions (YETI) Phone 

Study 

   

Description: The Youth Emotions, Thoughts, and Interactions (YETI) Phone Study aims to learn more about why some teenagers develop puzzling or unusual symptoms while others do not, researchers will study thinking patterns, stress responses, and social relationships in YETI phone study. 3 times over a 1-year period: participants will have a series of interviews and tests, a lab visit that includes completing tasks while connected to a heart rate monitor and providing saliva samples, and 14 days of at-home procedures that involve answering surveys and wearing a chest strap to monitor heart rate.

Age: 14-17

Contact: Megan Deam

230 McKee Place, Suite 138

(412) 864-2769

 

 

Leslie Horton, PhD 

 

Psychosis Risk Outcomes Network (ProNET) 

   

Why Participate in Research? You will have the opportunity to receive study-

related assessment, monitoring and education.

Your participation in research may help

contribute in ways that will help young people

with mental health concerns in the future.

Learn More

About Us

If you are interested in learning more about

the ProNET study, please contact the study

staff. They will be happy to answer your

questions and provide you with more

information.

Contact Us

Megan Deam

Phone: 412-864-2769

Email: deamm@upmc.edu

The University of Pittsburgh Human Research

Protections Office has approved this research

study

ProNET: Psychosis

Risk Outcome

Network

Assessment and

identification for young

people at-risk for mental

illness

Currently Recruiting

The ProNET study is recruiting young people who are concerned about the possibility of developing psychosis.

What is the purpose of this study?

Mental illness affects many individuals and

often begins to develop in adolescence or

young adulthood. The primary purpose of this

study is to:

• Improve the ability to identify youth at-risk

of developing psychosis

• Better understand why some young

people develop psychosis and others do

not

This research project aims to increase

understanding of mental health concerns in

young people and how to prevent the

development of a more serious mental illness.

Eligibility

Some individuals may be at higher risk of developing psychosis than others. This study is recruiting people who have experiences or circumstances that may put them at higher risk.

You may be eligible for this study if you meet

the following criteria:

• Ages 12-30

• Noticing a recent change in thinking,

behavior, or experiences, such as:

o Confusion about what is real or

imaginary

o Feeling not in control of your own

thoughts of ideas

o Feeling suspicious or paranoid

o Having experiences that may not be

real, such as hearing sounds or seeing

things that may not be there

o Having trouble communicating clearly

Most people who have these symptoms do not

go on to develop psychosis. We are trying to

understand why some people have these

experiences do develop psychosis while many

others do not.

What Would I Do?

You would first meet with the study staff for an

interview to determine if you are eligible for

the study. You would then complete several

assessments, including:

Clinical Interview

The clinical interview focuses on questions

about your daily life, such as your friendships

and school or work, and about different

experiences and symptoms.

Biological Assessments

These include Magnetic Resonance Imaging

(MRI) brain scans and saliva, urine and blood

testing.

Cognitive Testing

These assessments focus on memory,

attention, concentration and learning.

Assessment and identification for young people at-risk for mental illness

For more For For more information, please contact:

Megan Deam 412-864-2769

Deamm@upmc.edu

u The University of Pittsburgh Human Research Protections Office has approved this study

You may be eligible for this study is you meet the following criteria:

• Ages 12-30

• Noticing a recent change in thinking, behavior, or experiences, such as:

o Confusion about what is real or imaginary o Feeling not in control of your own thoughts of ideas o Feeling suspicious or paranoid o Having experiences that may not be real, such as hearing sounds or seeing things that may not

be there o Having trouble communicating clearly

Most people who have these symptoms do not go on to develop psychosis. We are trying to understand why some people have these experiences do develop psychosis while many others do not.

Vishwajit Nimgaonkar, MD, PhD

Cromoglicate Adjunctive Therapy for Outpatients with Schizophrenia (CATOS)

CATOS STUDYSEEKING INDIVIDUALS WHO:• Are aged 18-65 years• Have a diagnosis of Schizophrenia OR Schizoaffective

Disorder

PARTICIPANTS WILL RECEIVE:• Compensation up to $220.00 + travel expenses• Study evaluations and study medication• 12-week study• Bi-weekly visits

CONTACT:(412) 246-6356 (office)(878) 670-3587 (cell)(878) 670-3586 (cell)

vankirks@upmc.eduweseskyma@upmc.edu

 

 

Konasale Prasad, MD 

 

Genetics & Neuroimaging of Early Onset Schizophrenia 

(GENEOS) 

   

Contact the GENEOS study

today:

Recruiter

Diana Mermon Phone: (412) 586-9000 mermond@upmc.edu

Recruiter

Lauren Miller Phone: (412) 586-9309 millerl25@upmc.edu

GENEOS

Genetics & Neuroimaging of Early

Onset Schizophrenia

How you can help researchers learn

more about schizophrenia

For more information: 412-586-9000

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Early Onset

Schizophrenia Schizophrenia is a severe brain disease

that presents with symptoms such as

hearing voices or seeing things when

there is nothing there (hallucinations),

having ideas that others don’t share

(delusions), or having little emotion,

drive, or motivation. This illness often

affects a person’s ability to think clearly

and relate to other people, causing

considerable declines in personal, social

and job functioning.

In most cases, symptoms begin between

late adolescence to young adulthood. In

some cases, symptoms can become

apparent much earlier. Often,

individuals with early onset

schizophrenia experience more severe

symptoms than their adult counterparts.

Despite this increased severity, little is

known about the brain structure,

function and their relationship with

thinking, memory and attention among

persons with early onset schizophrenia.

Schizophrenia affects people of all races

and cultural backgrounds across the

world. We do not know exactly what

causes this illness, and more effective

treatments are needed.

Who may participate?

We need help from young people

experiencing symptoms such as auditory or

visual hallucinations, feeling that if they have

special powers, are receiving messages, or

that others are conspiring against them.

Participation in the GENEOS study does not

affect your current or future treatment. We

also need help from typically developing

participants with no history of psychiatric

problems.

How do I participate?

To learn more about GENEOS or to make a

referral, call the GENEOS coordinators at 412-

586-9000 or 412 586 9309 to talk about your

eligibility and to schedule an initial evaluation.

We will make every effort to make these

appointments convenient. All calls are

confidential.

The GENEOS Study

The GENEOS study is interested in early onset

schizophrenia to fill gaps in knowledge,

encouraging the development of future

effective treatments. We are interested in the

relationship between thinking, brain structure,

brain function, and genetic factors in

individuals with early onset schizophrenia as

compared to healthy individuals.

Will I need to travel? There is no travel required for the screening phase

of the study. However, you will be required to come

to UPMC Western Psychiatric for testing and the

MRI.

Is there a cost to participate? There is no cost to you to participate in this study.

We will reimburse you for travel to the clinic, and

you will receive compensation for completing the

initial and follow-up assessments.

What is done at screening?

You will be asked some simple questions

about you and your medical history.

After these questions, research staff will

review the study with you, so that you

can decide if you’d like to participate.

What will I be asked to do?

The GENEOS study takes place over 3

visits in one-year: the initial visit, a 6-

month follow-up, and a 12-month follow

up. At each of these visits, participants

will be interviewed, and you will answer

questions about your health and

symptoms. You will also undergo an MRI

to take brain pictures, computer tests on

memory, attention, and concentration,

and a receive a blood draw at each visit.

GENEOS Research study Researchers at the University of Pittsburgh and Western Psychiatric

Institute and Clinic are conducting a research study that seeks to

understand the causes and mechanisms of severe mental illnesses.

Eligible participants will complete questionnaires, undergo MRI, paper

and pencil testing and provide blood samples. Participants will be

compensated for their time. We can do part of the visit virtually. Participants must:

• Be diagnosed with Schizophreniform disorder, Schizophrenia or

Schizoaffective disorder

• be between the ages of 12 and 21 years

For more details, and to see whether you qualify, Contact GENEOS 412-586-9000 or mermond@upmc.edu

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Dean Salisbury, PhD

Pathology and Pathophysiology in Early Psychosis

Phone: (412)-586-9237

Clinical Neurophysiology Research Lab

3501 Forbes Avenue Suite 420

Pittsburgh, PA 15213

WWW.CNRL.PITT.EDU

Pathology and Pathophysiology in

Early Psychosis

CLINICAL

NEUROPHYSIOLOGY

RESEARCH

LABORATORY

How can I participate?

Contact our recruiter at (412)-586-9237.

S/he will ask you several questions to see if

you are eligible for our study. If you are

eligible, you will then be asked to come in to

our laboratory at Western Psychiatric

Hospital for the next study procedures. If

voicemail is reached please leave your name,

number, and age.

How long is this study?

The study procedures last between 7-9 hours

which can be split across several

appointments. The study will be repeated

approximately 3, 6 and 12 months from

baseline for a total of four timepoints.

Will I be compensated?

Individuals will be compensated for their

time.

Am I eligible for this study?

Individuals with Psychosis:

Experiencing first psychotic episode. Healthy Comparisons:

No personal or family history of a

psychiatric disorder

Both:

Are between the ages of 14 and 40

Do not have a history of head

trauma, seizures, ECT

Do not have a history of a learning

disorder

Do not have a recent history of

alcohol or drug abuse

Have normal hearing

CLINICAL NEUROPHYSIOLOGY RESEARCH LABORATORY University of Pittsburgh School of Medicine

What is this study’s

purpose?

Our lab is studying how attention

affects sensory signal processing

(such as sound) in individuals

experiencing their first episode of

psychosis. To do this we are using

EEG, MEG, and MRI. All imaging

techniques are noninvasive. The

combined use of functional

(pathophysiology) EEG and MEG

imaging and structural (pathology)

MRI imaging will be used to see if

there are any effects of attention

in sound processing between

people experiencing their first

episode of psychosis compared to

individuals not experiencing

psychosis.

What is an EEG?

EEG is a technique used to record the natural

electrical activity generated by the brain. During

an EEG an individual wears a nylon cap that has

lots of little holes. These holes are filled with a gel

and have sensors placed into them. These

sensors pick up electrical activity and send it to a

computer where it is recorded. EEG is considered

non-invasive because nothing is put into a

participant’s body. There is very minimal risk of

being harmed.

What is an MEG?

MEG is a technique used to record the natural

magnetic fields generated by the brain. To

measure these magnetic fields, the MEG uses

specialized sensors which are placed just above

the head. The sensors inside the machine will

record the magnetic fields in the brain and send it

to the computer. Like EEG, MEG is considered

non-invasive, which means nothing is put into

the individuals body. For this reason, there is a

very minimal risk of being harmed in the MEG.

What is an MRI?

MRI is a technique used to create images of the

brain. Before an MRI an individuals will be

screened for any metal in or outside of the body.

This is because the MRI uses a giant magnet, as

well as radio frequencies to create detailed images

of the brain. MRI is also considered noninvasive,

safe, and painless.

What will this study

involve?

1. A 15-20 minute long

screening interview over the

telephone to see if you are

eligible for our study

2. Computerized tests to

measure your attention and

learning.

3. A hearing test and interview

with a clinician.

4. EEG/MEG scans that will

record your brain’s natural

electrical/magnetic activity as

you listen to different sounds

and respond to auditory

stimuli.

5. MRI to get structural images

of your brain.

All study procedures will be

performed again 3, 6, and 12

months after study entrance.

Schizophrenia and Psychotic Disorders MEG/EEG and MRI

Study

Have you experienced hallucinations (hearing voices), paranoia, or other psychotic symptoms for the first time within

the last year? Have you received a diagnosis of Schizophrenia in the last year?

The University of Pittsburgh seeks people aged 18-40 who have recent onset schizophrenia or psychotic disorder to participate in a research study of perception, memory, sensory attention, and

brain function. This study will use MEG/EEG to measure the natural electrical activity of your brain while MRI will be used to

generate a structural image of your brain. Must have no history of head trauma, seizures, electroconvulsive (“shock”) therapy, and no recent history of alcohol or drug abuse. Compensates up to

$775 over 12 months.

If you are interested or would like to learn more about the

study, please call and leave a message at (412) 586-9237.

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Schizophrenia/Psychotic Disorders

MEG/EEG and MRI Study

Have you experienced hallucinations (hearing voices), paranoia, or other psychotic symptoms for the first time in the

last year?

Have you received a diagnosis of Schizophrenia in the last year?

The University of Pittsburgh seeks people aged 14-17 who have recent onset schizophrenia or psychotic disorder to participate in a research study of perception, memory, sensory attention, and brain function. This study will use MEG/EEG to measure

the natural electrical activity of your brain while MRI will be used to generate a structural image of your brain. Must have no history

of head trauma, seizures or electroconvulsive (shock) therapy, and no recent history of alcohol or drug abuse. Participants will be

compensated up to $775 over 12 months.

If you are interested or would like to learn more about the study, please have a parent call and leave a message at

(412) 586-9237. W

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Deepak Sarpal, MD 

 

A Multidimensional Dissection of Antipsychotic Treatment 

Response in Early Schizophrenia (DARES) 

 

 

7 Tesla Neuroimaging Reseach Study A Multidimensional Dissection of Antipsychotic Treatment Response in Early

Schizophrenia

Our understanding of the neurobiology underlying response to antipsychotic treatment is limited. In addition, we also have no biologically-based tests to help us predict whether a patient will respond to treatment with antipsychotic drugs.

In this research study, we aim to:

1) Examine the functional neurobiology that underlies response to antipsychotic treatment.

2) Develop a clinical test that uses a brain scan to predict response to treatment.

Eligible individuals:

• Aged 18-40. • Starting antipsychotic treatment. • Are experiencing significant, measurable psychotic symptoms. • Are within the first year of antipsychotic treatment.

If you have any questions or would like to make a referral, please contact:

Annie Blazer blazera@upmc.edu (412) 864 - 3636 Deepak Sarpal, M.D. sarpaldk@upmc.edu (412) 246 - 5618