Transgenic Organism

Transgenic OrganismBy: Alan Nguyen

What is it?Transgenic Organisma.k.a. Gentically modified organism (GMO)Any organism that has been genetically engineered to express a certain gene(s).Recombinant DNA technology Dolly the Sheep (1996-2003)First sheep to be successfully cloned Engineered through somatic cell nuclear transferCell nucleus of adult cell + (unfertilized oocyte nucleus)Electrical impulse is applied surrogate mother.

Research Dolly was cloned by Ian Wilmut & Keith Campbell at the Roslin Institute (Edinburgh, Scotland)Roslin Institute* enhance human & animal life Disease resistanceSustainability & productivity Diseases: understanding trans-species jumpEnhance quality of life

Ian Wilmut and Dolly the Sheep*http://www.roslin.ed.ac.uk/

Where do we go from here?Cloning is POSSIBLE!Roslin Institute is researching cloning on bigger animals such as horses and bullsCloning humans? Possibly.Bringing back extinct species?Pyrenean Ibex (2000)Spixs Macaw (2004)West African Black Rhino (2006)

Wait! What about Dolly?Spent her entire life at the Roslin Institute.She produced 6 lambs during her lifespan.Euthanized on Feb. 14, 2003 due to severe arthritis and lung cancer called Jaagsiekte.Common illness among sheep kept indoorsScientists do not attribute her short lifespan to cloning

BibliographyPaul G Shiels, Alexander J. Keith H.S. Campbell, Ian Wilmut, David Waddington, Alan Colman, Angelika E. Schnieke. Clone. June 1999, 1(2): 119-112. doi:10.1089/15204559950020003Embryonic Stem Cell Research and Respect for Human Life: Philosophical and Legal Reflections; McCartney, James J. 65 Alb. L. Rev. 597 (2001-2002)THE END

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