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Think Science: Memory - Dr. Isabel Muzzio
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Transcript of Think Science: Memory - Dr. Isabel Muzzio
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Isabel A. MuzzioDepartment of Biology
University of Texas at San Antonio
Think ScienceMemory
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Why study learning and memory?
1. Alzheimer’s, Korsakoff’s, stroke
2. Down’s syndrome, mental retardation
3. Too much memory? PTSD, other maladaptive learned behaviors
4.Philosophical issuesRoman orator Marcus Tulle's Cicero (104-63 B.C.) Memory is the
treasury and guardian of all things.
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Declarative memories•Episodic memories: Events happening in
particular contexts at specific times
•Semantic memories: Knowledge and concepts about particular subjects
•Requires conscious attention
•Strong evidence indicated that the medial temporal lobe including the hippocampus is required for this type of memory
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Role of the hippocampus in contextual gating of aversive events
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Henry Molaison
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The strange case of patient H.M.Treated for epilepsy in 1953 (27 yrs old)
Bilateral excision of medial temporal lobes
Little effects on perception, intelligence
Suffers from anterograde amnesia (cannot form new memories)
Lived in a nursing home in Hartford until 2008
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Anterograde
Retrograde
Anterograde vs. retrograde amnesia
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Place cell recordings
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Place Cells respond to Local Cues
Rotate With Visual Cues ‘Remap’ in New Contexts
Context A Context B Context A
6.9
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Muzzio Lab Research Interests
•How emotions affect memory?
•What is the relationship between sleep and memory?
•How do we learn to reorient in space?
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How are emotional memories represented in the brain?
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Role of the hippocampus in contextual gating of aversive events
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Extinction of fear
Fearful responding in a safe context is unnecessary and can be detrimental, so
animals must be able to learn when contexts are no longer dangerous
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Sleep across the lifespan