TH ST CONGRESS SESSION H. R. 3537 · PDF fileI 114TH CONGRESS 1ST SESSION H. R. 3537 To amend...

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114TH CONGRESS 1ST SESSION H. R. 3537

To amend the Controlled Substances Act to clarify how controlled substance

analogues are to be regulated, and for other purposes.

IN THE HOUSE OF REPRESENTATIVES

SEPTEMBER 17, 2015

Mr. DENT (for himself, Mr. HIMES, Mr. MEEHAN, Mr. DOLD, Mr. TIBERI,

Mr. COSTELLO of Pennsylvania, Mr. HANNA, Mr. THOMPSON of Pennsyl-

vania, Mr. ROGERS of Kentucky, Mr. MURPHY of Pennsylvania, Mr.

BARLETTA, Ms. NORTON, Mr. LANCE, Mrs. COMSTOCK, Mr. KATKO, Ms.

ROS-LEHTINEN, and Mr. JOLLY) introduced the following bill; which was

referred to the Committee on Energy and Commerce, and in addition to

the Committee on the Judiciary, for a period to be subsequently deter-

mined by the Speaker, in each case for consideration of such provisions

as fall within the jurisdiction of the committee concerned

A BILL To amend the Controlled Substances Act to clarify how con-

trolled substance analogues are to be regulated, and for

other purposes.

Be it enacted by the Senate and House of Representa-1

tives of the United States of America in Congress assembled, 2

SECTION 1. SHORT TITLE. 3

This Act may be cited as the ‘‘Synthetic Drug Con-4

trol Act of 2015’’. 5

VerDate Sep 11 2014 01:09 Sep 22, 2015 Jkt 049200 PO 00000 Frm 00001 Fmt 6652 Sfmt 6201 E:\BILLS\H3537.IH H3537SS

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SEC. 2. CONTROLLED SUBSTANCE ANALOGUES. 1

(a) EXPANSION OF DEFINITION.— 2

(1) IN GENERAL.—Clauses (i), (ii), and (iii) of 3

section 102(32)(A) of the Controlled Substances Act 4

(21 U.S.C. 802(32)(A)) are amended by striking 5

‘‘substantially’’ each place it appears. 6

(2) RULE OF CONSTRUCTION.—Section 7

102(32)(A) of the Controlled Substances Act (21 8

U.S.C. 82(32)(A)) shall not be construed to require 9

that a substance satisfy more than one of the 10

clauses listed in such section 102(32)(A) to meet the 11

definition of a controlled substance analogue. 12

(b) LIMITATION ON TREATMENT AS CONTROLLED 13

SUBSTANCES.—Section 203 of the Controlled Substances 14

Act (21 U.S.C. 813) is amended by inserting before the 15

period at the end the following: ‘‘for purposes of prohibi-16

tions, restrictions, and other requirements with respect to 17

manufacture, importation, distribution, and sale’’. 18

SEC. 3. TREATMENT OF CERTAIN DESIGNER DRUGS AS 19

SCHEDULE I CONTROLLED SUBSTANCES. 20

(a) IN GENERAL.—Schedule I, as set forth in section 21

202(c) of the Controlled Substances Act (21 U.S.C. 22

812(c)) is amended by adding at the end the following: 23

‘‘(e)(1) Unless specifically exempted or unless listed 24

in another schedule, any material, compound, mixture, or 25

preparation which contains any quantity of a substances 26


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•HR 3537 IH

listed in paragraphs (2) through (10), or which contains 1

the salts, isomers, and salts of isomers thereof whenever 2

the existence of such salts, isomers, and salts of isomers 3

is possible within the specific chemical designation. 4

‘‘(2) PHENYLALKYLAMINES.—The substances listed 5

in this paragraph consist of the following 6

phenylalkylamines: 7

‘‘(A) 2–(ethylamino)–1–(4-methylphenyl)–1- 8

propanone. 9

‘‘(B) 1–(4-ethylphenyl)–2–(methylamino)–1- 10

propanone. 11

‘‘(C) 1–(3-fluorophenyl)–2–(methylamino)–1- 12

propanone. 13

‘‘(D) 1–(4-fluorophenyl)–2–(methylamino)–1- 14

propanone. 15

‘‘(E) 1–(4-methoxyphenyl)–2–(methylamino)–1- 16

propanone. 17

‘‘(F) 2–(ethylamino)–1–(4-methoxyphenyl)–1- 18

propanone. 19

‘‘(G) 1–(2-naphthalenyl)–2–(1-pyrrolidinyl)–1- 20

pentanone. 21

‘‘(H) 1–(1,3-benzodioxol-5-yl)–2–(ethylamino)– 22

1-propanone. 23

‘‘(I) 1–(1,3-benzodioxol-5-yl)–2–(methylamino)– 24

1-butanone. 25


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‘‘(J) 1–(1,3-benzodioxol-5-yl)–2– 1

(methylamino)–1-pentanone. 2

‘‘(K) 2–(ethylamino)–1-phenyl-1-propanone. 3

‘‘(L) 1-phenyl-2–(1-pyrrolidinyl)–1-propanone. 4

‘‘(M) 1–(4-methylphenyl)–2–(1-pyrrolidinyl)–1- 5

propanone. 6

‘‘(N) 1–(4-methoxyphenyl)–2–(1-pyrrolidinyl)– 7

1-propanone. 8

‘‘(O) 1–(1,3-benzodioxol-5-yl)–2–(1- 9

pyrrolidinyl)–1-propanone. 10

‘‘(P) 1-phenyl-2–(1-pyrrolidinyl)–1-pentanone. 11

‘‘(Q) 2-amino-1–(4-fluoro)–1-propanone. 12

‘‘(R) 2–(methylamino)–1-phenyl-1-pentanone. 13

‘‘(S) 2–(ethylamino)–1–(4-ethylphenyl)–1- 14

propanone. 15

‘‘(T) 2–(dimethylamino)–1-phenyl-1-propanone. 16

‘‘(U) 1–(1,3-benzodioxol-5-yl)–2–(1- 17

pyrrolidinyl)–1-butanone. 18

‘‘(V) 1–(methylphenyl)–2–(1-pyrrolidinyl)–1- 19

hexanone. 20

‘‘(W) 2–(methylamino)–1-phenyl-1-butanone. 21

‘‘(X) 2–(methylamino)–1-p-tolyl-1-butanone. 22

‘‘(Y) 1–(4-methylphenyl)–2–(1-pyrrolidinyl)–1- 23

butanone. 24


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‘‘(Z) 1–(3,4-dimethylphenyl)–2–(methylamino)– 1

1-propanone. 2

‘‘(AA) 1-phenyl-2–(1-pyrrolidinyl)–1-butanone. 3

‘‘(BB) 1–(1,3-benzodioxol-5-yl)–2– 4

(dimethylamino)–1-propanone. 5

‘‘(CC) 1–(4-methylphenyl)–2–(benzylamino)–1- 6

propanone. 7

‘‘(DD) 1–(1-naphthy)–2–(1-pyrrolidinyl)–1- 8

pentanone. 9

‘‘(EE) 1–(1,3-benzodioxol-5-yl)–2– 10

(benzylamino)–1-propanone. 11

‘‘(FF) 1–(1,3-benzodioxol-5-yl)–2– 12

(benzylamino)–1-butanone. 13

‘‘(GG) 1–(1,3-benzodioxol)–2-[hydroxy(methyl)- 14

amino]-1-propanone. 15

‘‘(HH) 1–(1,3-benzodioxol-5-yl)–2– 16

(dimethylamino)–1-butanone. 17

‘‘(II) 2–(ethyl(methyl)amino)–1-phenyl-buta-18

none. 19

‘‘(JJ) 1–(4-bromophenyl)–2–(methylamino)–1- 20

propanone. 21

‘‘(KK) 2–(ethyl(methyl)amino-1-phenyl-1- 22

propanone. 23

‘‘(LL) 2–(methylamino)–1-m-tolyl-1-propanone. 24


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‘‘(MM) 2–(pyrrolidin-1-yl)–1–(thiophen-2-yl)–1- 1

pentanone. 2

‘‘(NN) 1–(4-fluorophenyl)–2–(methylamino)–1- 3

butanone. 4

‘‘(OO) 1–(4-methoxyphenyl)–2–(pyrrolidin-1- 5

yl)–1-butanone. 6

‘‘(PP) 1–(4-ethylphenyl)–2–(pyrrolidin-1-yl)–1- 7

butanone. 8

‘‘(QQ) 1–(4-methoxy-3-methylphenyl)–2– 9

(methylamino)–1-propanone. 10

‘‘(RR) 2–(ethylamino)–1–(3-methylphenyl)–1- 11

propanone. 12

‘‘(SS) 2-amino-(1H-indol-5-yl)propan-1-one. 13

‘‘(TT) 1-phenyl-2–(piperidin-1-yl)butan-1-one. 14

‘‘(UU) 2-methylamino-1–(2,4,5- 15

trimethylphenyl)-propan-1-one). 16

‘‘(VV) 1-phenyl-2–(pyrrolidin-1-yl)heptan-1-one. 17

‘‘(WW) 1-phenyl-2–(pyrrolidin-1-yl)hexan-1-one. 18

‘‘(XX) 1–(4-fluorophenyl)–2–(pyrrolidin-1- 19

yl)pentan-1-one. 20

‘‘(YY) 1–(benzo[d][1,3]dioxol-5-yl)–2– 21

(dimethylamino)pentan-1-one. 22

‘‘(ZZ) 1–(2-fluorophenyl)–N-methyl-propan-2- 23

amine. 24

‘‘(AAA) 1–(2-fluorophenyl)-propan-2-amine. 25


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‘‘(BBB) 1–(3-fluorophenyl)- propan-2-amine. 1

‘‘(CCC) 1–(3-fluorophenyl)–N-methyl-propan-2- 2

amine. 3

‘‘(DDD) 1–(4-fluorophenyl)- propan-2-amine. 4

‘‘(EEE) 1–(4-fluorophenyl)–N-methyl-propan-2- 5

amine. 6

‘‘(FFF) 1–(4-methylphenyl)propan-2-amine. 7

‘‘(GGG) N-ethyl-N-methyl-1-phenylpropan-2- 8

amine. 9

‘‘(HHH) 1–(benzofuran-4-yl)propan-2-amine. 10

‘‘(III) 1–(benzofuran-5-yl) propan-2-amine. 11

‘‘(JJJ) 1–(2,3-dihydrobenzofuran-5-yl)proan-2- 12

amine. 13

‘‘(KKK) 1–(benzofuran-6-yl)- propan-2-amine. 14

‘‘(LLL) 1–(2,3-dihydrobenzofuran-6-yl)proan-2- 15

amine. 16

‘‘(MMM) 1–(4-methoxyphenyl)–N-methyl- 17

propan-2-amine. 18

‘‘(NNN) N,N-dimethyl-1-phenylpropan-2-amine. 19

‘‘(OOO) 1–(2,3-dihydro-1H-inden-5-yl)propan- 20

2-amine. 21

‘‘(PPP) 5,6,7,8-tetrahydrobenzo[1,3]- 22

benzodioxol-7-amine. 23

‘‘(QQQ) a-methyl-4–(methylthio)-benzene- 24

ethanamine. 25


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‘‘(RRR) 1–(4-chlorophenyl)-propan-2-amine. 1

‘‘(SSS) 1–(2,4,6-trimethoxyphenyl)-propan-2- 2

amine. 3

‘‘(TTT) 1–(2,4,5-trimethoxyphenyl)-propan-2- 4

amine. 5

‘‘(UUU) 1–(2,5-dimethylphenyl)-propan-2- 6

amine. 7

‘‘(VVV) 1–(3,4-dimethylphenyl)-propan-2- 8

amine. 9

‘‘(WWW) N–(1-phenylpropan-2-yl)propan-1- 10

amine. 11

‘‘(XXX) 4–(2-aminopropyl)phenol. 12

‘‘(YYY) 3,4-methylenedioxy-N,N-dimethyl-am-13

phetamine. 14

‘‘(ZZZ) N-ethyl-1–(4-methoxyphenyl)propan-2- 15

amine. 16

‘‘(AAAA) 1–(benzofuran-5-yl)–N-methylpropan- 17

2-amine. 18

‘‘(BBBB) 6,7-dihydro-5H-inden[5,6- 19

d][1,3]dioxol-6-amine. 20

‘‘(CCCC) 5-iodo-2,3-dihydro-1H-inden-2-amine. 21

‘‘(DDDD) 2,3-dihydro-1H-inden-2-amine. 22

‘‘(EEEE) 5-methoxy-6-methyl-2,3-dihydro-1H- 23

inden-2-amine. 24


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‘‘(FFFF) N-methyl-6,7-dihydro-5H- 1

cyclopenta[1,3]-benzodioxol-6-amine. 2

‘‘(GGGG) N-methyl-2,3-dihydro-1H-inden-2- 3

amine. 4

‘‘(HHHH) 2-[4–(2-fluoroethylthio)–2,5- 5

dimethoxyphenyl]ethanamine. 6

‘‘(IIII) 8-bromo-2,3,6,7-tetrahydro-benzo[1,2- 7

b;4,5-b’]difuran-4-ethanamine. 8

‘‘(JJJJ) 4-iodo-2,5-dimethoxy-N-[(2- 9

methoxyphenyl)-methyl-benzene-ethamine. 10

‘‘(KKKK) 2–(4-chloro-2,5-dimethoxyphenyl)– 11

N–(2-methoxybenzyl)-ethanamine. 12

‘‘(LLLL) 2–(2,5-dimethoxy-3,4- 13

dimethylphenyl)-ethanamine. 14

‘‘(MMMM) 2–(4-methyl-2,5-dimethoxyphenyl)– 15


‘‘(NNNN) 2–(4-ethyl-2,5-dimethoxyphenyl)–N– 17

(2-methoxybenzyl)-ethanamine. 18

‘‘(OOOO) 2–(2,5-dimethoxy-3,4- 19

dimethylphenyl)–N–(2-methoxybenzyl)-ethanamine. 20

‘‘(PPPP) 2–(2,5-dimethoxyphenyl)–N–(2-me-21

thoxybenzyl)-ethanamine. 22

‘‘(QQQQ) 2–(4-bromo-2,5-dimethoxyphenyl)– 23



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‘‘(RRRR) 2–(2,5-dimethoxyphenyl-4-nitro)–N- 1

[(2-methoxyphenyl)methyl]-ethanamine. 2

‘‘(SSSS) 1–(4-iodo-2,5- 3

dimethoxyphenyl)propan-2-amine. 4

‘‘(TTTT) 1–(4-bromofuro[2,3-f]benzofuran-8- 5

yl)propan-2-amine. 6

‘‘(UUUU) 1–(4-chloro-2,5- 7


‘‘(VVVV) 1–(4-bromo-2,3,6,7- 9

terahydrofuro[2,3-f]benzofuran-8-yl)propan-2-amine. 10

‘‘(WWWW) (2,5-dimethoxyphenyl)-propan-2- 11

amine. 12

‘‘(XXXX) 1-[4–(ethylthio)–2,5- 13


‘‘(YYYY) 1–(4-ethoxy-2,5- 15


‘‘(ZZZZ) 1-[2,5-dimethoxy-4– 17

(propylthio)phenyl]propan-2-amine. 18

‘‘(AAAAA) 1–(4-ethyl-2,5- 19


‘‘(BBBBB) N-benzyl-2-phenylethanamine. 21

‘‘(CCCCC) N,N-dimethyl-2-phenylethanamine. 22

‘‘(DDDDD) 6-chloro-aminotetralin. 23

‘‘(EEEEE) 2-phenyl-propan-1-amine. 24

‘‘(FFFFF) 2-phenethylamine. 25


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‘‘(GGGGG) 1-methylamino-1–(3,4- 1

methylendioxy-phenyl)propane. 2

‘‘(HHHHH) N-methyl-3- 3

phenylbicyclo[2.2.1]heptan-2-amine. 4

‘‘(IIIII) 1–(2-methoxyphenyl)–N-methylpropan- 5

2-amine. 6

‘‘(JJJJJ) 2–(4–(allyloxy)–3,5- 7

dimethoxyphenyl)ethanamine. 8

‘‘(KKKKK) 4-methylhexan-2-amine. 9

‘‘(LLLLL) 4-methyl-5-phenyl-2-amino- 10

oxazoline. 11

‘‘(MMMMM) N-methyl-1-thiophen-2-yl)propan- 12

2-amine. 13

‘‘(NNNNN) (3-dimethylamino-2,2- 14

dimethylpropyl)–4-aminobenzoate. 15

‘‘(OOOOO) 1–(4-fluorophenyl)–2– 16

(methylamino)-propan-1-ol. 17

‘‘(PPPPP) 4-methyl-5-p-tolyl-4,5-dihydrooxazol- 18

2-amine. 19

‘‘(QQQQQ) 1-phenyl-2–(pyrrolidin-1-yl)propan- 20

1-ol. 21

‘‘(3) CANNABIMIMETIC AGENTS.—The substances 22

listed in this paragraph consist of the following 23

cannabimimetic agents: 24


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‘‘(A) (4-ethyl-1-naphthalenyl)(1-pentyl-1H- 1

indol-3-yl)methanone. 2

‘‘(B) 2–(2-methylphenyl)–1–(1-pentyl-1H-indol- 3

3-yl)-ethanone. 4

‘‘(C) 1-[1–(2-cyclohexylethyl)–1H-indol-3-yl]-2– 5

(2-methoxyphenyl)-ethanone. 6

‘‘(D) [1–(5-fluoropentyl)–1H-indol-3-yl](2- 7

iodophenyl)methanone. 8

‘‘(E) (2-methyl-1-[(1-methylpiperidin-2- 9

yl)methyl]-6-nitro-1H-indol-3-yl)methanone. 10

‘‘(F) (1-butyl-1H-indol-3-yl)(4-methoxyphenyl)- 11

methanone. 12

‘‘(G) (1-butyl-1H-indol-3-yl)(4- 13

methylnaphthalen-1-yl)methanone. 14

‘‘(H) [1–(5-fluoropentyl)–1H-indol-3-yl](4- 15

methyl-1-naphthalenyl)-methanone. 16

‘‘(I) [1-[(1-methyl-2-piperidinyl)methyl]-1H- 17

indol-3-yl]-1-naphthalenyl-methanone. 18

‘‘(J) 3–(4-methoxyphenyl)–2-methyl-1-[(2–(4- 19

morpholinyl)ethyl)–1H-indol-3-yl]-methanone. 20

‘‘(K) [2,3-dihydro-5-methyl-3–(4- 21

morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin- 22

6-yl]-1-naphthalenyl- methanone. 23

‘‘(L) 2–(3-methoxyphenyl)–1–(1-pentyl-1H- 24

indol-3-yl)-ethanone. 25


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‘‘(M) (2-iodophenyl)[1-[(1-methyl-2- 1

piperidinyl)methyl]-1H-indol-3-yl]-methanone. 2

‘‘(N) [1-[(1-methyl-2-piperdinyl)methyl]-1H- 3

indol-3-yl]tricycle[3.3.1.13,7]dec-1-yl-methanone. 4

‘‘(O) 1-naphthalenyl(1-propyl-1H-indol-3-yl)- 5

methanone. 6

‘‘(P) 5-[3–(1-naphthoyl)–1H-indole-1- 7

yl]pentanenitrile. 8

‘‘(Q) 3–(1-naphthenylmethyl)–1-pentyl-1H- 9

indole. 10

‘‘(R) (2-methyl-1-propyl-1H-indol-3-yl)–1- 11

napthalenyl-methanone. 12

‘‘(S) 1-naphthalenyl[1–(4-penten-1-yl)–1H- 13

indol-3-yl]-methanone. 14

‘‘(T) (4-bromonaphthalen-1-yl)(1-pentyl-1H- 15


‘‘(U) (4-fluoronaphthalen-1-yl)(1-pentyl-1H- 17


‘‘(V) (2-methyl-1-phenyl-1H-indol-3-yl)–1- 19

naphthalenyl-methanone. 20

‘‘(W) 2–(2-chlorophenyl)–1–(1-pentyl-1H-indol- 21

3-yl)-ethanone. 22

‘‘(X) [1–(5-chloropentyl)–1H-indol-3-yl](2- 23

iodophenyl)-methanone. 24


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‘‘(Y) (adamantan-1-yl)(1-pentyl-1H-indol-3-yl)- 1

methanone. 2

‘‘(Z) (2-iodo-5-nitrophenyl)-[1–(1- 3

methylpiperidin-2-ylmethyl)–1H-indol-3-yl]- 4

methanone. 5

‘‘(AA) (1-pentyl-1H-indol-3-yl)(2,2,3,3- 6

tetramethylcyclo-propyl)methanone. 7

‘‘(BB) [1–(5-fluoropentyl-1H-indol-3- 8

yl)](2,2,3,3-tetramethylcyclo-propyl)methanone. 9

‘‘(CC) [1–(2-morpholinoethyl)–1H-indol-3- 10

yl](2,2,3,3-tetramethylcyclopropyl)methanone. 11

‘‘(DD) 1-[(tetrahydro-2H-pyran-4-yl)methyl]- 12

1H-indol-3-yl-(2,2,3,3- 13

tetramethylcyclopropyl)methanone. 14

‘‘(EE) 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl- 15

1H-indole-3-carboxamide. 16

‘‘(FF) 1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl- 17

1H-indazole-3-carboxamide. 18

‘‘(GG) 1–(5-fluoropentyl)–N- 19

tricyclo[3.3.1.13,7]dec-1-yl-1H-indole-3-carboxamide. 20

‘‘(HH) [1–(5-chloropentyl)–1H-indol-3- 21


‘‘(II) (1-isopentyl-1H-indol-3-yl)(naphthalen-1- 23

yl)methanone. 24


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‘‘(JJ) 1–(5-fluoropentyl-N- 1

tricyclo[3.3.1.13,7]dec-1-yl-1H-indazole-3- 2

carboxamide. 3

‘‘(KK) (1-pentyl-1H-indol-3-yl)(4-propyl-1- 4

naphthalenyl)-methanone. 5

‘‘(LL) [1–(5-chloropentyl)–1H-indol-3- 6


‘‘(MM) (4-methyl-naphthalen-1-yl)[1–(pent-4- 8

en-1-yl)–1H-indol-3-yl]methanone. 9

‘‘(NN) (2-methoxy-1-naphthalenyl)(1-pentyl- 10

1H-indol-3-yl)methanone. 11

‘‘(OO) (3-methoxy-phenyl)(1-pentyl-1H-indol-3- 12

yl)methanone. 13

‘‘(PP) [1–(5-fluoropentyl)–1H-indol-3-yl](4- 14

ethyl-1-naphthalenyl)-methanone. 15

‘‘(QQ) quinolin-8-yl 1-pentyl-1H-indole-3- 16

carboxylate. 17

‘‘(RR) quinolin-8-yl 1–(5-fluoropentyl-1H- 18

indole-3-carboxylate. 19

‘‘(SS) 1–(cyclohexylmethyl)–8-quinolinyl-ester- 20

1H-indole-3-carboxylic acid. 21

‘‘(TT) N–(1-amino-3-methyl-1-oxobutan-2-yl)– 22

1-pentyl-1H-indazole-3-carboxamide. 23

‘‘(UU) 1–(5-fluoropentyl)–N–(naphthalene-1- 24

yl)–1H-indole-3-carboxamide. 25


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‘‘(VV) N–(1-amino-3-methyl-1-oxobutan-2-yl)– 1

1–(4-fluorobenzyl)–1H-indazole-3-carboxamide. 2

‘‘(WW) N–(1-amino-3,3-dimethyl-1-oxobutan-2- 3

yl)–1–(4-fluorobenzyl)–1H-indazole-3-carboxamide. 4

‘‘(XX) N–(1-amino-3,3-dimethyl-1-oxobutan-2- 5

yl)–1-pentyl-1H-indole-3-carboxamide. 6

‘‘(YY) 2-iodophenyl)(1-pentyl-1H-indol-3- 7

yl)methanone. 8

‘‘(ZZ) [5–(2-methylphenyl)–1-pentyl-1H-pyrrol- 9

3-yl]-1-naphthalenyl-methanone. 10

‘‘(AAA) 1-pentyl-N–(naphthalene-1-yl)–1H- 11

indole-3-carboxamide. 12

‘‘(BBB) 1–(5-chloropentyl)–1H-indol-3-yl](4- 13

methyl-1-naphthalenyl)-methanone. 14

‘‘(CCC) (4-methyl-naphthalen-1-yl)[2-methyl-1– 15

(pent-4-en-1-yl)–1H-indol-3-yl)]methanone. 16

‘‘(DDD) [1–(5-fluoropentyl)–1H-indol-3-yl](o- 17

tolyl)methanone. 18

‘‘(EEE) (2-ethylphenyl)(1–(5-fluoropentyl)–1H- 19


‘‘(FFF) [1–(5-chloropentyl)–1H-indol-3- 21

yl](naphthalen-1-yl)methanone. 22

‘‘(GGG) [1–(5-bromopentyl)–1H-indol-3- 23

yl](naphthalen-1-yl)methanone. 24


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17

•HR 3537 IH

‘‘(HHH) (1–(5-fluoropentyl)–1H-indazol-3- 1

yl)(naphthalene-1-yl)methanone. 2

‘‘(III) 1-[(1-methyl-2-piperidinyl)methyl]-1H- 3

indol-3-yl](2,2,3,3- 4


‘‘(JJJ) (1–(1-methylazepan-2-yl)–1H-indol-3- 6

yl)(2,2,3,3-tetramethylcyclopropyl)methanone. 7

‘‘(KKK) 4-hydroxy-3,3,4-trimethyl-1–(1-pentyl- 8

1H-indol-3-yl)pentan-1-one. 9

‘‘(LLL) [1–(4-fluoropentyl)–1H-indol-3-yl]-1- 10

naphthenyl-methanone. 11

‘‘(MMM) 2–(2-iodophenyl)–1–(1-pentyl-1H- 12

indol-3-yl)ethanone. 13

‘‘(NNN) (1-hexyl-1H-indol-3-yl)(2,2,3,3- 14


‘‘(OOO) (2,2,3,3-tetramethylcyclopropyl)[1– 16

(4,4,4-trifluorobutyl)–1H-indol-3-yl]methanone. 17

‘‘(PPP) 7-methoxy-1–(2-morpholinoethyl)–N– 18

((1S,4R)–1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)– 19

1H-indole-3-ca rboxamide. 20

‘‘(QQQ) quinolin-8-yl 1–(4-fluorobenzyl)–1H- 21

indole-3-carboxylate. 22

‘‘(RRR) naphthalen-1-yl 1–(4-fluorobenzyl)– 23

1H-indole-3-carboxylate. 24


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18

•HR 3537 IH

‘‘(SSS) N–(1-amino-3,3-dimethyl-1-oxobutan-2- 1

yl)–1-pentyl-1H-indazole-3-carboxamide. 2

‘‘(TTT) N–(1-amino-3,3-dimethyl-1-oxobutan-2- 3

yl)–1–(5-fluoropentyl)–1H-indole-3-carboxamide. 4

‘‘(UUU) (1–(4-fluoropentyl)–1H-indol-3- 5


‘‘(VVV) 1-naphthalenyl(1-pentyl-1H-indazol-3- 7

yl)methanone. 8

‘‘(WWW) N-naphthalenyl-1-pentyl-1H-indazole- 9

3-carboxamide. 10

‘‘(XXX) N–(1-amino-3-methyl-1-oxobutan-2- 11

yl)–1–(cyclohexyl methyl)–1H-indazole-3- 12

carboxamide. 13

‘‘(YYY) naphthalene-1-yl(9-pentyl-9H-carbazol- 14

3-yl)methanone. 15

‘‘(ZZZ) naphthalene-1-yl 1–(5-fluoropentyl)– 16

1H-indole-3-carboxylate. 17

‘‘(AAAA) methyl 3-methyl-2–(1-pentyl-1H-inda-18

zole-3-carboxamido. 19

‘‘(BBBB) methyl 2–(1–5-fluoropentyl)–1H-in-20

dazole-3-caboxamido)–3-methylbutanoate. 21

‘‘(CCCC) N-benzyl-1-pentyl-1H-indole-3- 22

carboxamide. 23

‘‘(DDDD) N-benzyl-1–(5-fluoropentyl)–1H- 24

indole-3-carboxamide. 25


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19

•HR 3537 IH

‘‘(EEEE) methyl 2–(1–(4-fluorobenzyl)–1H-in-1

dazole-3-carboxamido)–3-methylbutanoate. 2

‘‘(FFFF) quinolin-8-yl 1-pentyl-1H-indazole-3- 3

carboxylate. 4

‘‘(GGGG) quinolin-8-yl 1–(5-fluoropentyl)–1H- 5

indazole-3-carboxylate. 6

‘‘(HHHH) naphthalene-2-yl 1–(2- 7

fluorophenyl)–1H-indazole-3-carboxylate. 8

‘‘(IIII) N–(1-amino-3,3-dimethyl-1-oxobutan-2- 9

yl)–1–(cyclohexylmethyl)–1H-indazole-3- 10

carboxamide. 11

‘‘(JJJJ) (1–(4-flourobenzyl)–1H-indol-3- 12


‘‘(KKKK) N–(1-amino-1-oxo—3-phenylpropan- 14

2-yl)–1–(5-fluoropentyl)–1H-indole-3-carboxamide. 15

‘‘(LLLL) N–(1-amino-1-oxo—3-phenylpropan- 16

2-yl)–1–(5-fluoropentyl)–1H-indazole-3-carboxamide. 17

‘‘(MMMM) methyl (1–(cyclohexylmethyl)–1H- 18

indazole-3-carbonyl-L-valinate. 19

‘‘(NNNN) N-[(1–(cyclohexylmethyl)–1H-inda-20

zole-3yl)carbonyl]-3-methyl-L-valine, methyl ester. 21

‘‘(OOOO) methyl 2–(1–(cyclohexylmethyl)–1H- 22

indole-3-carboxamido)–3,3-dimethylbutanoate. 23

‘‘(PPPP) (1–(5-fluoropentyl)–1H- 24

benzo[d]imidazole-2-yl)(naphthalene-1-yl)methanone. 25


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20

•HR 3537 IH

‘‘(QQQQ) (1–(4-fluorobenzyl)–1H-indol-3- 1

yl)(napthalen-1-yl)methanone. 2

‘‘(RRRR) methyl 2–(1–(4-fluorobenzyl)–1H-in-3

dazole-3-carboxamido)–3,3-dimethylbutanoate. 4

‘‘(SSSS) quinolin-8-yl 1–(4-fluorobenzyl)–1H- 5

indazole-3-carboxylate. 6

‘‘(TTTT) N–(adamantan-1-yl)–1–(4- 7

fluorobenzyl)–1H-indazole-3-carboxamide. 8

‘‘(UUUU) N–(1-amino-3-methyl-1-oxobutan-2- 9

yl)–1–(5-fluoropentyl)–1H-indole-3-carboxamide. 10

‘‘(VVVV) 2-[(1S,3R)–3-hydroxycyclohexyl]-5– 11

(2-methylheptyl-2-yl)phenol. 12

‘‘(WWWW) 2-[(1S,3R)–3-hydroxycyclohexyl]-5– 13

(2-methyldodecanyl-2-yl)phenol. 14

‘‘(XXXX) 3-hydroxy-2[3-methyl-6–(1- 15

methylethyenyl)–2-cyclohexen-1-yl]-5-pentyl-2,5- 16

cyclohexadiene-1,4-dione. 17

‘‘(YYYY) 4-[4–(1,1-dimethylheptyl)–2,6- 18

dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2- 19

ene-2-methanol. 20

‘‘(ZZZZ) 1-naphthalenyl[4–(pentylox)–1- 21

naphthalenyl]-methanone. 22

‘‘(AAAAA) 3–(2–(hydroxymethyl)–2,3-dihydro- 23

1H-inden-4-yloxy)phenyl 4,4,4-trifluorobutane-1- 24

sulfonate. 25


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21

•HR 3537 IH

‘‘(BBBBB) N–(benzo[1,3]dioxol-5-ylmethyl)–7- 1

methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3- 2

carboxamide. 3

‘‘(CCCCC) N-[3–(2-methoxyethyl)–4,5- 4

dimethylthiazol-2-ylidene]-2,2,3,3- 5

tetramethylcyclopropane-carboxamide. 6

‘‘(DDDDD) 5-chloro-3-ethyl-N-[4–(piperidin-1- 7

yl)phenethyl)–1H-indole-2-carboximide. 8

‘‘(EEEEE) N-[4–(dimethylamino)phenethyl]-3- 9

ethyl-5-fluoro-1H-indole-2-carboximide. 10

‘‘(FFFFF) N–(1-benzylpyrrolidin-3-yl)–5- 11

chloro-3-ethyl-1H-indole-2-carboxamide. 12

‘‘(GGGGG) [5–(2-fluorophenyl)–1-pentyl-1H- 13

pyrrol-3-yl](naphthalene-1-yl)methanone. 14

‘‘(HHHHH) (3’-(aminocarbonyl)[1,1’-biphenyl]- 15

3-yl)-cyclohexyl-carbamate. 16

‘‘(IIIII) 5–(biphenyl-4-ylmethyl)–N,N-dimethyl- 17

1H-tetrazole-1-carboxamide. 18

‘‘(JJJJJ) 6-methyl-2–(p-tolylamino)–4H- 19

benzo[d][1,3]oxazin-4-one. 20

‘‘(KKKKK) [1,1’-biphenyl]-3-yl-carbamic acid, 21

cyclohexyl ester. 22

‘‘(LLLLL) 4-hydroxy-N–(4-hydroxyphenethyl)– 23

3–(pentylamino)-benzamide. 24


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22

•HR 3537 IH

‘‘(MMMMM) 3’-carbamoyl-6-hydroxy-[1,1’- 1

biphenyl]-3-yl cyclohexylcarbamate. 2

‘‘(4) ARYLCYCLOHEXAMINES.—The substances listed 3

in this paragraph consist of the following 4

arylcyclohexamines: 5

‘‘(A) 1–(3-methoxyphenyl)–N-propylcyclohexan- 6

amine. 7

‘‘(B) 2–(ethylamino)–2–(3- 8

methoxyphenyl)cyclohexanone. 9

‘‘(C) 1-phenylcyclohexan-amine. 10

‘‘(D) 1-[1–(benzothiophen-2- 11

yl)cyclohexyl]piperidine. 12

‘‘(E) 1–(1-p-tolylcyclohexyl)-piperidine. 13

‘‘(F) 1–(4-methoxyphenyl)–N-propylcyclohexan- 14

amine. 15

‘‘(G) 1-[1–(4-methoxyphenyl)cyclohexyl]-piper-16

idine. 17

‘‘(H) 1-[1–(3-methoxyphenyl)cyclohexyl]-piper-18

idine. 19

‘‘(I) 1-phenyl-N-propylcyclohexanamine. 20

‘‘(J) N–(2-methoxyethyl)–1-phenylcyclohexan- 21

amine. 22

‘‘(K) N–(2-ethoxyethyl)–1-phenylcyclohexan- 23

amine. 24


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•HR 3537 IH

‘‘(L) N–(3-methoxypropyl)–1-phenylcyclohexan- 1

amine. 2

‘‘(M) 3-[1–(piperidin-1-yl)cyclohexyl]-phenol. 3

‘‘(N) 2–(methoxyphenyl)–2– 4

(methylamino)cyclohexanone. 5

‘‘(O) N-ethyl-1–(thiophen-2-yl)cyclohexanamine. 6

‘‘(P) (2–(2-chlorophenyl)–2–(ethylamino)- 7

cyclohexanone). 8

‘‘(5) TRYPTAMINES.—The substances listed in this 9

paragraph consist of the following tryptamines: 10

‘‘(A) 2–(1H-indol-3-yl)–N-methyl-ethanamine. 11

‘‘(B) N–(2–(1H-indol-3-yl)ethyl-N- 12

methylpropan-2-amine. 13

‘‘(C) N-[2–(1H-indol-3-yl)ethyl]-N- 14

isopropylpropan-2-amine. 15

‘‘(D) N,N-dipropyl-1H-indole-3-ethanamine. 16

‘‘(E) 3-[2–(diethylamino)ethyl]-1H–4yl acetate. 17

‘‘(F) 3–(2-[isopropyl(methyl)amino]ethyl)–1H- 18

indol-4-ol. 19

‘‘(G) 3-[2–(bis[1-methylethyl]amino)ethyl]-1H- 20

indol-4-ol acetate. 21

‘‘(H) 3–(2-[isopropyl(methyl)amino]ethyl)–1H- 22

indol-4-ol acetate. 23

‘‘(I) 3-[2–(dimethylamino)ethyl]-1H-indol-4-yl 24

acetate. 25


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24

•HR 3537 IH

‘‘(J) 4-hydroxy-N,N-diethyl-1H-indole- 1

ethanamine. 2

‘‘(K) 4-methoxy-N,N-dimethyl-1H-indole-3- 3

ethanamine. 4

‘‘(L) 3–(2–(diisopropylamino)ethyl)–1H-indol-4- 5

ol. 6

‘‘(M) 3-[2–(ethyl[methyl]amino)ethyl]-1H-indol- 7

4-ol. 8

‘‘(N) 3-[2–(ethyl[methyl]amino)ethyl]-1H-indol- 9

4-yl acetate. 10

‘‘(O) 3–(2–(dipropylamino)ethyl)–1H-indol-4-ol. 11

‘‘(P) 3-[2–(dipropylamino)ethyl]-1H-indol-4-yl 12

acetate. 13

‘‘(Q) 4-acetoxy-N,N-di-2-propen-1-yl-1H-indole- 14

3-ethanamine. 15

‘‘(R) 5-methoxy-N,N-di-2-propen-1-yl-1H- 16

indole-3-ethanamine. 17

‘‘(S) 3–(2–(dimethylaminoethyl)–1H-indol-5-ol. 18

‘‘(T) 2–(5-methoxy-1H-indol-3-yl)–N,N- 19

dimethylethanamine. 20

‘‘(U) N-[2–(5-methoxy-1H-indol-3-yl)ethyl]-N- 21

methylpropyl. 22

‘‘(V) 1–(5-methoxy-1H-indol-3-yl)propan-2- 23

amine. 24


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•HR 3537 IH

‘‘(W) 3-[2–(dimethylamino)-ethyl]-1H-indol-5-yl 1

acetate. 2

‘‘(X) N-[2–(5-methoxy-1H-indol-3-yl)ethyl]-N- 3

propylpropan-1-amine. 4

‘‘(Y) N,N-diethyl-2–(5-methoxy-1H-indol-3- 5

yl)ethanamine. 6

‘‘(Z) N-ethyl-2–(5-methoxy-1H-indol-3-yl)–N- 7

methyl-ethanamine. 8

‘‘(6) BENZYLPIPERIDINES.—The substances listed in 9

this paragraph consist of the following benzylpiperidines: 10

‘‘(A) 2–(diphenylmethyl)-piperidine. 11

‘‘(B) 2-benzhydrylpyrrolidine. 12

‘‘(C) a,a-diphenyl-(pyrrolidin-2-yl)methanol. 13

‘‘(D) methyl 2–(3,4-dichlorophenyl)–2– 14

(piperdin-2-yl)acetate. 15

‘‘(E) methyl 2–(3-chlorophenyl)–2–(piperidin-2- 16

yl)acetate. 17

‘‘(F) methyl 2–(piperidin-2-yl)–2-p-tolylacetate. 18

‘‘(G) methyl 2–(4-fluorophenyl)–2–(piperidin-2- 19

yl)acetate. 20

‘‘(H) ethyl 2-phenyl-2–(piperidin-2-yl)acetate. 21

‘‘(7) BENZODIAZEPINES.—The substances listed in 22

this paragraph consist of the following benzodiazepines: 23

‘‘(A) 4–(2-chlorophenyl)–2-ethyl-9-methyl-6H- 24

thieno-[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine. 25


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•HR 3537 IH

‘‘(B) 7-bromo-5–(2-chlorophenyl)–1H- 1

benzo[e][1,4]diazepin-2(3H)-one. 2

‘‘(C) 8-bromo-1-methyl-6-phenyl-4H- 3

[1,2,4]triazolo[4,3a][1,4]benzodiazepine. 4

‘‘(D) 3-methyl-6-[3– 5

(trifluoromethyl)phenyl][1,2,4]triazol[4,3- 6

b]pyridazine. 7

‘‘(E) 6–(5-chloro-2-pyridyl)–6,7-dihydro-7-oxo- 8

5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1- 9

carboxylate. 10

‘‘(8) OPIOIDS AND OPIOID-LIKE SUBSTANCES.—The 11

substances listed in this paragraph consist of the following 12

opioids and opioid-like substances: 13

‘‘(A) 2–(1,3-dimethoxybuta-1,3-dien-2-yl)–3- 14

ethyl-8-methoxy-1,2,3,4,6,7,12,12b- 15

octahydroindolo[2,3-a]quin olizine. 16

‘‘(B) (2a,4aR,6aR,7R,9S,10aS10bR)-methyl-9- 17

acetoxy-2–(furan-3-yl)–6a,10b-dimethyl-4,10- 18

dioxododecahydro-1 H-benzo[f]isochromene-7- 19

carboxylate. 20

‘‘(C) 3,4-dichloro-N–([1– 21

(dimethylamino)cyclohexyl]methyl)benzamide. 22

‘‘(D) 3-[2–(amino-1-methylethyl)–1- 23

hydroxycyclohexyl]-phenol. 24

‘‘(E) 4,5-epoxy-17-methylmorphinan-3-ol. 25


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•HR 3537 IH

‘‘(F) N-phenyl-N-[1–(2-phenethyl)–4- 1

piperidinyl] acetamide. 2

‘‘(G) N–(1-benzylpiperidin-4-yl)–N–(x- 3

fluorophenyl)-butanamide. 4

‘‘(H) 2-methyl-N-phenyl-N-[1–(1-phenylpropan- 5

2-yl)piperidin-4-yl]propanamide. 6

‘‘(I) N–(1-phenethylpiperidin-4-yl)–N- 7

phenylbutyramide. 8

‘‘(J) 1-cyclohexyl-4–(1,2-diphenylethyl)-piper-9

azine. 10

‘‘(K) N-phenyl-N–(1–(2–(thiophen-2- 11

yl)ethyl)piperidin-4-yl)acetamide. 12

‘‘(L) 4-chloro-N–(1-phenethylpiperidin-2- 13

ylidene)benzenesulfonamide. 14

‘‘(M) 4-chloro-N–(1–(4- 15

nitrophenethyl)piperidin-2- 16

ylidene)benzenesulfonamide. 17

‘‘(9) PIPERAZINES.—The substances listed in this 18

paragraph consist of the following piperazines: 19

‘‘(A) 1,4-dibenzylpiperazine. 20

‘‘(B) 1–(4-bromo-2,5-dimethoxybenzyl)-piper-21

azine. 22

‘‘(C) 1–(4-fluorophenyl)-piperazine. 23

‘‘(D) 1–(2-methoxyphenyl)-piperazine. 24

‘‘(E) 1–(4-chlorophenyl)-piperazine. 25


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•HR 3537 IH

‘‘(F) 1–(4-methoxyphenyl)-piperazine. 1

‘‘(G) 1–(3-methylbenzyl)piperazine. 2

‘‘(H) 1-benzyl-4-methylpiperazine. 3

‘‘(10) TROPANE ALKALOIDS.—The substances listed 4

in this paragraph consist of the following tropane alka-5

loids: 6

‘‘(A) 8-methyl-8-azabicyclo[3.2.1]octan-3-yl 4- 7

fluorobenzoate. 8

‘‘(B) methyl 3–(4-fluorophenyl)–8-methyl-8- 9

azabicyclo[3.2.1]octane-2-carboxylate.’’. 10

(b) EFFECTIVE DATE.—The amendment made by 11

subsection (a) takes effect on the date that is 30 days 12

after the date of enactment of this Act. 13

Æ


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TH ST CONGRESS SESSION H. R. 3537 · PDF fileI 114TH CONGRESS 1ST SESSION H. R. 3537 To amend...

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Transcript of TH ST CONGRESS SESSION H. R. 3537 · PDF fileI 114TH CONGRESS 1ST SESSION H. R. 3537 To amend...