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W W W. E S D R .O R G # E S D R2019

E S D R A N N U A L

M E E T I N G

C O N N E C T I N G S K I NS C I E N C E A N D H E A L T H

B O R D E A U X , F R A N C E1 8 — 2 1 S E P T E M B E R 2 0 1 9

P R O G R A M B O O K

49TH

ACKNOWLEDGEMENTS

Sponsors of the 49th Annual ESDR Meeting 2019

CORPORATE PARTNERS & PLATINUM SPONSORS

PLATINUM SPONSORS

GOLD SPONSORS

SILVER SPONSORS

GENERAL SPONSORS

3

ACKNOWLEDGEMENTS

MEETING APP

POSTER PRIZES

TRAVEL GRANTS

LILLY SCHOLARSHIPS

PATIENT ORGANISATIONS

4

CONTENTS

WELCOME ........................................................................................................................................................................................................................ 5

COMPLETE DAILY PROGRAM OVERVIEW ................................................................................................................................................................. 7

PROGRAM AT GLANCE ................................................................................................................................................................................................ 10

FLOORPLANS ............................................................................................................................................................................................................... 18

EXHIBITION ................................................................................................................................................................................................................... 20

DETAILED SCIENTIFIC PROGRAM ............................................................................................................................................................................ 23

WEDNESDAY 18 SEPTEMBER 2019 ......................................................................................................................................................................... 23

EUROPEAN EPIDERMAL BARRIER RESEARCH NETWORK .........................................................................................................................................................................................................................................................25

17TH MEETING OF THE EUROPEAN EPIDERMAL BARRIER RESEARCH NETWORK (E2BRN) .................................................................................................................................................................................25

FRENCH SOCIETY FOR RESEARCH IN DERMATOLOGY.................................................................................................................................................................................................................................................................27

DERMATOENDOCRINOLOGY .........................................................................................................................................................................................................................................................................................................................29

2019 FUTURE LEADERS SYMPOSIUM .....................................................................................................................................................................................................................................................................................................31

INTERNATIONAL PSORIASIS COUNCIL – THE MECHANISTIC MODEL(S) OF PSORIASIS: AUTOIMMUNE AND/OR AUTOINFLAMMATORY? ......................................................................33

THURSDAY 19 SEPTEMBER 2019 ............................................................................................................................................................................. 35

DRUG DISCOVERY AND TRANSLATIONAL MEDICINE ...................................................................................................................................................................................................................................................................37

EASTERN EUROPEAN RESEARCH ..............................................................................................................................................................................................................................................................................................................38

NEUROBIOLOGY OF THE SKIN ......................................................................................................................................................................................................................................................................................................................39

FRONTIERS IN SKIN BIOLOGY & DERMATOLOGY 1 & PLENARY SESSION 1 ..................................................................................................................................................................................................................40

SANOFI SYMPOSIUM – EPITHELIAL BARRIER DYSFUNCTION IN TYPE 2 INFLAMMATORY DISEASES .........................................................................................................................................................41

NOGRA PHARMA SYMPOSIUM – PPARS AS CONDUCTORS OF THE SKIN ORCHESTRA IN HEALTH IN DISEASE ................................................................................................................................42

NOVARTIS SYMPOSIUM – CHRONIC INFLAMMATORY DISEASES: FROM IMMUNOLOGY TO PERSONALIZED MEDICINE ..............................................................................................................43

CONCURRENT SESSION 1 – ADAPTIVE IMMUNITY AND AUTOIMMUNITY ....................................................................................................................................................................................................................44

CONCURRENT SESSION 2 – PHOTOBIOLOGY AND PIGMENTATION ..................................................................................................................................................................................................................................45

CONCURRENT SESSION 3 – EPIDERMAL STRUCTURE AND FUNCTION .........................................................................................................................................................................................................................46

CONCURRENT SESSION 4 – GENETICS, CELL BASED THERAPY AND WOUND HEALING ...................................................................................................................................................................................47

FRIDAY 20 SEPTEMBER 2019 .................................................................................................................................................................................... 51

GALDERMA SYMPOSIUM – A NEW TREATMENT OPTION FOR PATIENTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS: TARGETING THE IL-31/IL-31R

SIGNALING PATHWAY ..........................................................................................................................................................................................................................................................................................................................................53

HELSINNRECORDATI SYMPOSIUM – A DEEP DIVE INTO CHLORMETHINE GEL: FROM BENCH TO PATIENTS ........................................................................................................................................54

BIOTEST SYMPOSIUM – IMMUNOGLOBULIN THERAPY IN SEVERE AUTOIMMUNE SKIN DISEASES ...........................................................................................................................................................55

FRONTIERS IN SKIN BIOLOGY & DERMATOLOGY 2 & PLENARY SESSION 2 ..................................................................................................................................................................................................................56

POSTER VIEWING (ODD NUMBERS) ..........................................................................................................................................................................................................................................................................................................58

CELGENE SYMPOSIUM – TARGETING EXTRACELLULAR INFLAMMATORY MEDIATORS OR INTRACELLULAR PATHWAYS FOR DERMATOLOGICAL DISEASES:

WHICH IS BETTER? ................................................................................................................................................................................................................................................................................................................................................59

JANSSEN SYMPOSIUM – PATHWAYS TO SILENCING PSORIASIS: REMISSION OR CURE? ......................................................................................................................................................................................60

CHANEL SYMPOSIUM – SENESCENCE & SKIN AGING .................................................................................................................................................................................................................................................................61

ESDR ANNUAL GENERAL MEETING OF MEMBERS .........................................................................................................................................................................................................................................................................65

SATURDAY 21 SEPTEMBER 2019 ............................................................................................................................................................................. 67

CONCURRENT SESSION 5 – INNATE IMMUNITY AND INFLAMMATION ...........................................................................................................................................................................................................................69

CONCURRENT SESSION 6 – CLINICAL RESEARCH AND EPIDEMIOLOGY .......................................................................................................................................................................................................................70

CONCURRENT SESSION 7 – MELANOMA AND OTHER SKIN CANCERS .........................................................................................................................................................................................................................71

CONCURRENT SESSION 8 – STEM CELLS SKIN APPENDAGES AND TISSUE REGENERATION..........................................................................................................................................................................72

GENERAL POSTER SESSION (ALL AUTHORS TO BE BY THEIR POSTERS) ........................................................................................................................................................................................................................73

CLLINICAL SATURDAY: NEXT GENERATION HEALTHCARE .........................................................................................................................................................................................................................................................74

ESDR POSTER PRIZES AND CLOSING CEREMONY .........................................................................................................................................................................................................................................................................75

SKIN EPIGENETICS ................................................................................................................................................................................................................................................................................................................................................75

NOVEL ASPECTS IN VASCULAR BIOLOGY OF THE SKIN .............................................................................................................................................................................................................................................................76

POSTER WALKS ............................................................................................................................................................................................................ 77

MEETING ORGANISERS ............................................................................................................................................................................................. 95

ABOUT THE ESDR......................................................................................................................................................................................................... 96

5

WELCOME

Welcome to ESDR 2019

The ESDR facilitates and drives initiatives to encourage high quality science, discussion, education and mentoring for our future leaders in skin science. One way of delivering

this mission is through our annual scientific meeting of the ESDR which, over the last 49 years, has become one of the go to meetings for both basic and clinical scientists to discuss and exchange new findings and ideas in skin science. It has expanded beyond Europe with many delegates and presenters attending from the other continents.

The 2019 meeting program not only builds on the successes of previous meetings but also includes changes to the program to further enhance scientific discussion and opportunities for both scientists and clinicians to present their data. We have a spacious poster area with more time in the program for poster viewing and discussion. There will be a large number of poster walks, electronic poster displays and opportunities for presenters to produce video poster uploads on the ESDR meeting website. In addition to posters and free oral communication sessions, we have a program filled with outstanding globally recognized invited speakers including in the Frontiers in Skin Biology and Dermatology plenary sessions. Our Future Leaders have organised another exciting symposium. Furthermore, we have special interest groups to hold satellite meetings at ESDR so that the full breadth of essential expertise is present at the meeting. We also bring together academia and biopharma in dedicated sessions to discuss new ideas in target discovery and clinical translation. Finally, the expanded poster viewing sessions alongside our social program creates an environment allowing exchange of ideas, humour and collaboration with old and new friends.

As the first non-clinical president of the ESDR and, on behalf of the ESDR board, I would like to encourage both basic and clinical scientists to join us at the ESDR meeting in 2019 to present your latest research in skin science and to interact both scientifically and socially with our international delegates. Thanks to Prof Alain Taïeb and the local organizing committee, we have the superb Bordeaux Congress Centre and a special social program to connect skin science and health.

We look forward to seeing you in Bordeaux!

Welcome from the ESDR President

David KelsellPresident, ESDR

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Dear Colleagues, Dear Friends,

Bordeaux, best known for its wine châteaux, is featured on the ESDR 2019 poster by one of its famous monuments known as ‘le pont de pierre’, a stone bridge erected after a decree of Napoleon in 1807.

Its construction was difficult because of the width of the river Garonne, floods and tides, as well as financial difficulties, but since its grand opening in 1822, the citizens of Bordeaux are very proud of their elegant bridge. From the stone bridge you can discover the magnificent 18th century architecture of the left bank and understand why the city belongs to UNESCO world heritage.

Connecting Skin Science and Health is an ambitious motto, but if the construction of the stone bridge on a large and sometimes tumultuous river was very challenging two centuries ago, dermatology has also achieved major and sometimes unexpected breakthroughs over the last two decades, and we owe the progresses not only to serendipity but also to good science applied to our favorite organ, skin. One of the pioneers in photodermatology, oncodermatology and dermatosurgery was the first chair and founder of the Bordeaux school of Dermatology, William-Auguste Dubreuilh (1857–1935). We are much honored to host the 49th meeting of the ESDR in the spirit of our motto, in full accordance with the vision of Dubreuilh one century ago.

Welcome to Bordeaux!

Welcome from the ESDR 2019 Local Organising Committee Chair

Alain Taïeb

ESDR 2019 Local Organising Committee Chair

7


Complete Daily Program Overview

PRO

GR

AMOVERVIEW

8

Wednesday 18 September 2019Time Session Location

08:25–18:30 European Epidermal Barrier Research Network Amphitheatre B

10:00–13:00 French Society for Research in Dermatology Amphitheatre C

13:00–17:00 Future Leaders Symposium Amphitheatre C

13:00–18:15 Dermatoendocrinology E1 + E2

14:00–18:00 International Psoriasis Council F1 + F2

Thursday 19 September 2019Time Session Location

08:30–10:15 Drug Discovery and Translational Medicine Amphitheatre A

08:30–10:30 Eastern European Research Amphitheatre B

08:30–10:30 Neurobiology of the Skin Amphitheatre C

10:30–11:00 Coffee Break Foyer, Exhibition & Poster Area

11:00–11:10 Opening Ceremony Amphitheatre A

11:15–12:55 Frontiers in Skin Biology & Dermatology 1 & Plenary Session 1 Amphitheatre A

13:00–14:30 Epithelial barrier dysfunction in type 2 inflammatory diseases Amphitheatre A

13:00–14:30 PPARs as conductors of the skin orchestra in health in disease Amphitheatre B

13:00–14:00 Chronic inflammatory diseases: from immunology to personalized medicine Amphitheatre C

14:40–16:10 Concurrent Session 1: Adaptive Immunity and Autoimmunity Amphitheatre A

14:40–16:10 Concurrent Session 2: Photobiology and Pigmentation E1 + E2

14:40–16:10 Concurrent Session 3: Epidermal Structure and Function Amphitheatre C

14:40–16:10 Concurrent Session 4: Genetics, Cell Based Therapy and Wound Healing Amphitheatre B

16:25 - 16:55 Rudi Cormane Lecture: Nick Reynolds Amphitheatre A

17:00 - 18:00 General Poster Session 1 Foyer, Poster Area

18:05 - 18:20 Intersociety Collegiality Awards Amphitheatre A

18:20 - 18:50 Special Guest Lecture: Pier-Vincenzo Piazza Amphitheatre A

18:50 - 21:15 Welcome Reception Foyer, Exhibition & Poster Area

COMPLETE DAILY PROGRAM OVERVIEW

9

Friday 20 September 2019Time Session Location

08:30–09:30 A new treatment option for patients with moderate-to-severe Atopic Dermatitis: Targeting the IL-31/IL-31R signaling pathway

Amphitheatre A

08:30–09:30 A deep dive into chlormethine gel: from bench to patients Amphitheatre B

08:30–09:30 Immunoglobulin Therapy in Severe Autoimmune

Skin Diseases

Amphitheatre C

09:35–10:05 Celgene ESDR Guest Lecture: Arturo Zychlinsky Amphitheatre A


11:55–12:55 Poster Walks (01–10) and Poster Viewing (Odd numbers) Foyer, Poster Area

13:00–14:30 Targeting extracellular inflammatory mediators or intracellular pathways for dermatological diseases: Which is better?

Amphitheatre A

13:00–14:30 Pathways to Silencing Psoriasis: Remission or Cure? Amphitheatre B

13:00–14:30 Senescence & Skin Aging Amphitheatre C

14:40–15:10 ESDR Guest Lecture: David E. Fisher Amphitheatre A

15:20–16:20 Poster Walks (11–20) and Poster Viewing (EVEN NUMBERS) Foyer, Poster Area

16:45–17:15 René Touraine Lecture: Marja Mikkola Amphitheatre A

17:20–17:35 ESDR Honorary Membership Awards Amphitheatre A

17:40–18:30 ESDR Annual General Meeting of Members Amphitheatre A

19:30–00:00 Social Networking Event Palais de la Bourse

Saturday 21 September 2019Time Session Location

09:00–10:30 Concurrent Sessions 5: Innate Immunity and Inflammation Amphitheatre A

09:00–10:30 Concurrent Session 6: Clinical Research and Epidemiology Amphitheatre B

09:00–10:30 Concurrent Session 7: Melanoma and Other Skin Cancers Amphitheatre C

09:00–10:30 Concurrent Session 8: Stem Cells, Skin Appendages and Tissue Regeneration E1 + E2

10:35–11:35 Poster Walks (21–30) and General Poster Viewing Foyer, Poster Area

11:45–12:15 EADV Guest Lecture: Tiago R. Matos Amphitheatre A

12:15–13:45 Clinical Saturday: Next-Generation Healthcare Amphitheatre A

13:45–14:00 ESDR Poster Prizes and Closing Ceremony Amphitheatre A

14:00–17:00 Skin Epigenetics Amphitheatre C

14:00–16:00 Novel aspects in vascular biology of the skin Amphitheatre B

10

PROGRAM AT GLANCEWEDNESDAY 18 SEPTEMBER

8:30 9:00 9:30 10:00 10:30 11:00 11:30 12:00 12:30 13:00 13:30 14:00 14:30 15:00 15:30 16:00 16:30 17:00 17:30

Amph

ithea

tre B

EEBRN

Amph

ithea

tre C

French Society for Research in Dermatology

Future Leaders Symposium

E1+E

2

Dermatoendocrinology

F1+F

2

International Psoriasis Council

11

WEDNESDAY 18 SEPTEMBER8:30 9:00 9:30 10:00 10:30 11:00 11:30 12:00 12:30 13:00 13:30 14:00 14:30 15:00 15:30 16:00 16:30 17:00 17:30

Amph

ithea

tre B

EEBRN

Amph

ithea

tre C


Future Leaders Symposium

E1+E

2

Dermatoendocrinology

F1+F

2

International Psoriasis Council

12

PROGRAM AT GLANCETHURSDAY 19 SEPTEMBER

8:30 9:00 9:30 10:00 10:15 11:00 11:30 12:00 12:30 13:00 13:30 14:00 14:30 15:00 15:30 16:00 16:30 17:00 18:00 18:30 19:00

Amph

ithea

tre A

Drug Discovery and Translational Medicine

Opening CeremonyFrontiers in Skin Biology & Dermatology (1)

Plenary Session 1

Epithelial Barrier Dysfunction in Type 2

Inflammatory Diseases (Sanofi)

Concurrent Session 1: Adaptive Immunity and Autoimmunity

(14:40–16:10)

Rudi Cormane Lecture:

Nick Reynolds(16:25–16:55)

JSID and SID Intersociety Collegiality Awards

Special Guest Lecture: Pier-Viencenzo Piazza

(18:10–18:50)

Amph

ithea

tre B

Eastern European Research

PPARs as Conductors of the Skin Orchestra in Health

in Disease (Nogra)

Concurrent Session 4: Genetics, Cell Based Therapy

and Wound Healing(14:40–16:10)

Amph

ithea

tre C Neurobiology of the Skin

Chronic Inflammatory Diseases: from Immunology

to Personalized Medicine (Novartis)

Concurrent Session 3: Epidermal Structure and Functions

(14:40–16:10)

E1+E

2 Concurrent Session 2: Photobiology and Pigmentation

(14:40–16:10)

13

THURSDAY 19 SEPTEMBER

8:30 9:00 9:30 10:00 10:15 11:00 11:30 12:00 12:30 13:00 13:30 14:00 14:30 15:00 15:30 16:00 16:30 17:00 18:00 18:30 19:00

Amph

ithea

tre A

Drug Discovery and Translational Medicine

Opening CeremonyFrontiers in Skin Biology & Dermatology (1)

Plenary Session 1

Epithelial Barrier Dysfunction in Type 2

Inflammatory Diseases (Sanofi)

Concurrent Session 1: Adaptive Immunity and Autoimmunity

(14:40–16:10)

Rudi Cormane Lecture:

Nick Reynolds(16:25–16:55)

JSID and SID Intersociety Collegiality Awards

Special Guest Lecture: Pier-Viencenzo Piazza

(18:10–18:50)

Amph

ithea

tre B

Eastern European Research

PPARs as Conductors of the Skin Orchestra in Health

in Disease (Nogra)

Concurrent Session 4: Genetics, Cell Based Therapy

and Wound Healing(14:40–16:10)

Amph

ithea

tre C Neurobiology of the Skin

Chronic Inflammatory Diseases: from Immunology

to Personalized Medicine (Novartis)

Concurrent Session 3: Epidermal Structure and Functions

(14:40–16:10)

E1+E

2 Concurrent Session 2: Photobiology and Pigmentation

(14:40–16:10)

14

PROGRAM AT GLANCEFRIDAY 20 SEPTEMBER

8:30 9:00 9:30 10:00 10:15 10:30 11:00 11:30 13:00 13:30 14:00 14:30 16:30 17:00 17:30 18:00

Amph

ithea

tre A

A New Treatment Option for Patients With

Moderate to Severe Atopic Dermatitis – Targeting

the IL31/ IL31 R Signaling Pathways (Galderma)

Celgene ESDR Guest

Lecture: Arthuro

Zychlinsky(09:35–10:05)

Frontiers in Skin Biology & Dermatology 2 + Plenary Session 2

(10:05–11:45)

Tagretting Extracellular Inflammatory Mediators or Incellular Pathways

for Dermatological Disease: Which is Better? (Celgene)

ESDR Guest Lecture: David E.

Fisher14:40–15:10

René Touraine Guest Lecture: Marja Mikkola

(16:45–17:10)

ESDR Honorary Membership Award

ESDR Annual General Meeting of Members

(17:20–18:30)

Amph

ithea

tre B

A Deep Dive into Chlormethine Gel:

from Bench to Patients (Helsinn)

Pathways to Silencing Psoriasis: Remission or Cure (Janssen)

Amph

ithea

tre C

Immunoglobulin Therapy in Severe Autoimmune Skin Diseases (Biotest)

Senescence & Skin aging (Chanel)

15

FRIDAY 20 SEPTEMBER

8:30 9:00 9:30 10:00 10:15 10:30 11:00 11:30 13:00 13:30 14:00 14:30 16:30 17:00 17:30 18:00

Amph

ithea

tre A

A New Treatment Option for Patients With

Moderate to Severe Atopic Dermatitis – Targeting

the IL31/ IL31 R Signaling Pathways (Galderma)

Celgene ESDR Guest

Lecture: Arthuro

Zychlinsky(09:35–10:05)

Frontiers in Skin Biology & Dermatology 2 + Plenary Session 2

(10:05–11:45)

Tagretting Extracellular Inflammatory Mediators or Incellular Pathways

for Dermatological Disease: Which is Better? (Celgene)

ESDR Guest Lecture: David E.

Fisher14:40–15:10

René Touraine Guest Lecture: Marja Mikkola

(16:45–17:10)

ESDR Honorary Membership Award

ESDR Annual General Meeting of Members

(17:20–18:30)

Amph

ithea

tre B

A Deep Dive into Chlormethine Gel:

from Bench to Patients (Helsinn)

Pathways to Silencing Psoriasis: Remission or Cure (Janssen)

Amph

ithea

tre C

Immunoglobulin Therapy in Severe Autoimmune Skin Diseases (Biotest)

Senescence & Skin aging (Chanel)

16

PROGRAM AT GLANCESATURDAY 21 SEPTEMBER

9:00 9:30 10:00 10:15 11:45 12:00 12:15 12:30 12:45 13:00 13:30 13:45 14:00 14:30 15:00 15:30 16:00 16:30

Amph

ithea

tre A

Concurrent Session 5: Innate Immunity and Inflammation

EADV Guest Lecture: Tiago R. Matos

Clinical Saturday: Next Generation Healthcare

ESDR Poster Prize and Closing Ceremony(13:45–14:00)

Amph

ithea

tre B

Concurrent Session 6: Clinical Research and Epidemiology

Novel Aspects in Vascular Biology of the Skin

Amph

ithea

tre C

Concurrent Session 7: Melanoma and Other Skin Cancers

Skin Epigenetics

E1+E

2 Concurrent Session 8: Stem Cells, Skin Appendages

and Tissue Regeneration

17

SATURDAY 21 SEPTEMBER

9:00 9:30 10:00 10:15 11:45 12:00 12:15 12:30 12:45 13:00 13:30 13:45 14:00 14:30 15:00 15:30 16:00 16:30

Amph

ithea

tre A

Concurrent Session 5: Innate Immunity and Inflammation

EADV Guest Lecture: Tiago R. Matos

Clinical Saturday: Next Generation Healthcare

ESDR Poster Prize and Closing Ceremony(13:45–14:00)

Amph

ithea

tre B

Concurrent Session 6: Clinical Research and Epidemiology

Novel Aspects in Vascular Biology of the Skin

Amph

ithea

tre C

Concurrent Session 7: Melanoma and Other Skin Cancers

Skin Epigenetics

E1+E

2 Concurrent Session 8: Stem Cells, Skin Appendages

and Tissue Regeneration

18

POSTER AREA E-POSTERSGround Floor – Palais des Congres – Bordeaux

FLOORPLANS

19

Ground Floor – Palais des Congres – Bordeaux

First Floor – Palais des Congres – Bordeaux

20

EXHIBITION

21

Notes

49TH

Wednesday 18 September 2019

DETAILED SCIENTIFIC PROGRAM

24

18Wednesday

Wednesday 18 September 2019

Time Session Location

08.25–18.30 European Epidermal Barrier Research Network Amphitheatre A

10.00–13.00 French Society for Research in Dermatology Amphitheatre C

13.00–17.00 Future Leaders Symposium Amphitheatre C

13.00–18.15 Dermatoendocrinology Room E1+E2

14.00–18.00 International Psoriasis Council Room F1+F2

25

WednesdayWednesday 18 September 201908.25–18.30 Room: Amphitheatre B

European Epidermal Barrier Research Network 17th Meeting of the European Epidermal Barrier Research Network (E2BRN)Scientific Organising Committee: Hanna Niehues (Nijmigen, The Netherlands), Dusko Ilic (London, United Kingdom)

Program08.25–08.30 Opening remarks

Johanna Brandner (Germany)

Session 1 chaired by Johanna Brandner & Ana Costa

08.30–09.00 Epidermal lipids in inflammatory skin diseases Joke Bouwstra (The Netherlands)

09.00–09.30 AFM-measured corneocyte rigidity in health and atopic dermatitis Marek Haftek (France)

09.30–10.00 Plasmin and the barrier Rainer Voegeli (Switzerland)

10.00–10.30 Short talks selected from abstracts Variability of topical penetration data from dermal open flow microperfusion might be attributed to variability in skin barrier function and follicular penetration Manfred Bodenlenz (Austria)

Quantitative measurement of in vivo skin penetration of topically applied materials by Raman spectroscopy Peter Caspers (The Netherlands)

10.30–11.00 Coffee Break

Session 2 chaired by Hanna Niehues & Julia Lachner

11.00–11.30 Applications of 3D skin equivalents to study skin disease pathophysiology and therapeutics Ellen van den Bogaard (The Netherlands)

11.30–12.00 RIPK4, an important mediator maintaining epidermal homeostasis Wim Declerq (Belgium)

26

Wednesday12.00–12.30 Short talks selected from abstracts Infection by dermatophytes of reconstructed human epidermis is impaired by PD169316 via inhibition of fungal growth Émilie Faway (Belgium)

TARgetting the cutaneous microbiota in atopic dermatitis by coal tar via AHR-dependent induction of antimicrobial peptides Jos Smits (The Netherlands)

12.30–13.30 Lunch

13.30–14.30 Poster Viewing

Session 3 chaired by Dusko Ilic & Irini Dijkhoff

14.30–15.00 Making sense of GWAS: genetic mechanisms in skin barrier formation Sara Brown (UK)

15.00–15.30 Autophagy at the epidermal barrier Leopold Eckhart (Austria)

15.30–16.00 Newly identified components of a stratum corneum structure known for a long time, the cornified cell envelope Michel Simon (France)

16.00–16.30 Short talks selected from abstracts The novel whey acidic protein WFDC12 is expressed in particular terminally differentiated keratinocytes Polina Kalinina (Austria)

Osmolyte-mediated cell volume regulation is dysregulated by ageing and following UV exposure in human skin April Foster (US)


Session 4 chaired by Patrick Zeeuwen & Joshua Broussard

17.00–17.30 Cell adhesion and polarity signalling in making and maintaining the epidermal barrier Matthias Rubsam (Germany)

17.30–18.00 Protective effect of Aquaphilus dolomiae Extract on Tight Junction-barrier function in a Staphylococcus aureus-infected-AD model Helène Duplan (France)

18.00–18.15 Poster Prizes

18.15–18.30 E2BRN network meeting

19.30 Dinner

27

WednesdayWednesday 18 September 201910.00–13.00 Room: Amphitheatre C


Program10.00–10.05 Introduction

Julien Seneschal (President of the French Society for Research in Dermatology)

10.05–10.30 Invited lecture How does mechanotransduction influence skin homeostasis? Chloé Féral (Nice, France)

10.30–10.40 Poster 056 Molecular diagnosis of skin allergy M Lefevre,1 A Nosbaum,1,2 F Hacard,2 F Berard,1,2 M Baeck,3 A Herman,3 M Bruze,4 C Svedman,4 J Nicolas1,2 and M Vocanson1 1Centre International de Recherche en Infectiologie (CIRI), Lyon, France, 2Allergy and Immunology, Lyon Sud University Hospital, Lyon, France, 3Dermatology, Saint Luc University Hospital, Bruxelles, Belgium and 4Dermatology, Lund University, Lund, Sweden

10.40–10.50 Poster 072 Activation status of cutaneous and blood eosinophils in Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

F Dezoteux,1,2,6 J Gibier,3 A Dendooven,4,2,6 B Lopez,4,2,6 A Bongiovanni,5,6 M Tardivel,3,6 G Lefèvre4,2,6 and D Staumont-Sallé1,2,6 1Service de Dermatologie, Univ. Lille, Lille, France, 2CEREO, Centre de référence national des syndromes hyperéosinophiliques, Univ. Lille, Lille, France, 3Institut de Pathologie, Univ. Lille, Lille, France, 4Laboratoire d’Immunologie et Unité d’immunologie Clinique, Univ. Lille, Lille, France, 5Bioimaging Center, Univ. Lille, France and 6Inserm U995 - LIRIC - Lille Inflammation Research International Center, Univ. Lille, France

10.50–11.00 Poster 046 Vitamin D3 promotes human Th2 responses by TSLP-dependent and -independent regulation of dendritic cells A Brulefert, V Flacher and C Mueller IBMC - I2CT - CNRS UPR3572, Strasbourg, France

11.05–11.30 Invited lecture The concept of pathogenic Th2 cells Christoph Schlapbach (Bern, Switzerland)

11.30–11.40 Poster 018 Evolution of autoreactive B and T cells in pemphigus patients with Rituximab or corticosteroid regimen treatment M Maho-Vaillant,1,2 C Pérals,4,5 M Golinski,1,2 V Hébert,1,2 G Riou,2,3 O Boyer,2,3 M Viguier,6 S Calbo,2,3 N Fazilleau4,5 and P Joly1,2 1Department of Dermatology, Rouen University Hospital, Rouen, France, 2Unit 1234, INSERM, Rouen, France, 3Normandy University, Rouen, France, 4Unit 1043, INSERM, Toulouse, France, 5UMR5282, CNRS, Toulouse, France and 6Department of Dermatology, University Hospital Center of Reims, Reims, France

11.40–11.50 Poster 465 Cutaneous T-cell lymphoma cells release proapoptotic Fas ligand in lysosomal secretory vesicles A De Masson,1 F Jean-Louis,2 C Chauvel,2 G Raposo,3 H Bachelez,1 A Bensussan,2 M Bagot1 and L Michel2 1Saint-Louis Hospital, Paris, France, 2U976, INSERM, Paris, France and 3CNRS U141, Institut Curie, Paris, France

11.50–12.00 Poster 505 Infantile Hemangioma angiogenesis and sensitivity to propranolol rely on a cross talk between vascular and perivascular stromal cells F Moisan,1 S Oucherif,1 P Kaulanjan-Checkmodine,1 S Prey,2 M Loot,2 C Leaute-Labreze,2 HR Rezvani1 and A Taieb1,2 1Dermatology, University of Bordeaux, Bordeaux, France and 2Dermatology, CHU Bordeaux, Bordeaux, France

28

Wednesday12.05–12.30 Invited lecture Human pluripotent stem cells for skin regenerative medicine and pathological modeling of epidermolysis bullosa Christine Baldeschi (Evry, France)

12.30–12.40 Poster 439 Melanoma cells export functional proteasomes by way of microvesiculation: a possible mechanism for generation of plasmatic proteasomes B Bergeret,1,2 A Bonhoure,3 L Henry,2 O Coux,4 L Meunier,1,2 M Vidal3 and P Stoebner1,2 1Dermatology Department, CHU Nîmes, Montpellier, France, 2IBMM, Montpellier, France, 3DIMNP, Montpellier, France and 4CRBM, Montpellier, France

12.40–12.50 Poster 542 Xeroderma Pigmentosum C mutations increase oxidative DNA damages by inhibiting Base Excision Repair System’s expression and activity N Fayyad,1 D Béal,1 HR Rezvani2 and W Rachidi1 1Univ. Grenoble Alpes, CEA, CNRS, IRIG/DIESE /CIBEST, Grenoble, France and 2Univ Bordeaux, Inserm, BMGIC, UMR U1035, Bordeaux, France

12.55–13.00 Conclusions

Notes

29

WednesdayWednesday 18 September 201913.00–18.15 Room: E1 + E2

DermatoendocrinologyOrganizers Markus Böhm (Münster, Germany) & Ralf Paus (Miami, FL, USA & Manchester, UK)

This meeting is supported by

Program

13.00–13.05 Welcome & Introduction Markus Böhm & Ralf Paus

13.05–13.35 Lecture 1 Hormonal control of skin pigmentation – what we have learned and what needs to be addressed (20 min + 10 min discussion) Mauro Picardo (Rome, Italy)

13.35–14.05 Lecture 2 Mineralocorticoid receptors in the skin: emerging targets for treating skin diseases? (20 min + 10 min discussion) Paloma Perez (Valencia, Spain)

14.05–14.17Oral presentation from selected ESDR poster abstracts Poster 242 Synthetic adiponectin-derived peptide enhances skin barrier function (8 min + 2 min discussion) Seung-Phil Hong (Wonju-si, Korea)

14.17–14.29Oral presentation from selected ESDR poster abstracts Poster 407 Novel transcriptomic network interactions in the human skin treated with topical glucocorticoids (8 min + 2 min discussion) Irina Budunova (Chicago, USA)

14.29–14.59Lecture 3 Repurposing of neuropharmacological drugs for dermatological indications: Concepts, challenges and vision (20 min + 10 min discussion) Christoph Abels (Bielefeld, Germany)


15.30–16.00 Lecture 4 Melancortin peptides in dermatology: from bench to bedside (20 min + 10 min discussion) Markus Böhm (Munster, Germany)

16.00–16.30 Lecture 5 Frontiers in cutaneous vitamin D research (20 min + 10 min discussion) Carsten Carlberg (Kuopio, Finland)

16.30–16.42

Oral presentation from selected ESDR poster abstracts Poster 599 PPARgamma signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicity (8 min + 2 min discussion) Marta Bertolini (Munster, Germany)

16.42–16.54Oral presentation from selected ESDR poster abstracts Poster 267 On the role of vitamin D receptor alternative splicing in human keratinocytes (8 min + 2 min discussion) Michal Zmijewski (Gdansk, Poland)


30

Wednesday17.10–17.40

Lecture 6 Hormonal control of skin and skin appendage development: An evolutionary-developmental perspective (20 min + 10 min discussion) Maksim Plikus (Irvine, USA)

17.40–18.10 Closing Lecture Clinical neuroendocrinology of the skin – my vision for the next decade (20 min + 10 min discussion) Thomas A. Luger (Munster, Germany)

18.10–18.15 Closing Remarks Ralf Paus & Markus Böhm

Notes

31

WednesdayWednesday 18 September 201913.00–17.00 Room: Amphitheatre C

2019 Future Leaders Symposium

Organising Committee

ESDR Katia Boniface (Bordeaux, France), Matthew Caley (London, UK), Julien Seneschal (Bordeaux, France), JSID Sei-ichiro Motegi (Gunma, Japan), Atsushi Otsuka (Kyoto, Japan)

The 2019 Future Leaders Symposium is supported by:

Program13.00–13.15 Welcome and Introduction

Katia Boniface, Sei-ichiro Motegi

Session 1 Chairs: Katia Boniface, Sei-ichiro Motegi

13.15–14.00 Scientific Presentations(12 minutes plus 3 minutes questions)

Proteomic research in dermatology Beatrice Dyring-Andersen (Copenhagen, Denmark)

Interferonopathies: from diagnosis to treatment Mathieu Rodero (Paris, France)

Gene therapy for recessive dystrophic epidermolysis bullosa: a translational journey Su Lwin (London, UK)

14.00–14.15 LEO Foundation Award Ceremony


Session 2 Chairs: Matthew Caley, Atsushi Otsuka

14.45–15.00 Scientific Presentation(12 minutes plus 3 minutes questions)

PD-L1 on mast cells negatively regulates effector CD8+ T-cell activation in the skin Tomoko Hirano (Kyoto, Japan)

32

Wednesday15.00–15.40 Keynote Speakers

An immunological way to classify inflammatory skin diseases Kilian Eyerich (Munich, Germany)

Science and Leadership Liv Eidsmo (Stockholm, Sweden)

15.40–15.45 Research Techniques Made Simple (RTMS) Sara Brown (Dundee, UK)

15.45–16.50 Session 3 Interactive Presentations

Part 1: LeaderershipNaomi Chambers (Manchester, UK)Chris Griffiths (Manchester, UK)

Part 2: PublicationsMark Udey, JID Editor (USA)

16.50–17.00 Closing Remarks

17.15- Depart for Future Leaders Dinner*

* Pre-registration for the Future Leaders Dinner has closed. A limited number of places may be available on the day. Please check during the coffee break on the day. Priority will be given to alumni from the ESDR Future Leaders Academy, Summer Research Workshops, SID Residents Retreat, JSID Kisaragi Juku and young scientists under 40.

Notes

33

WednesdayWednesday 18 September 201914.00–18.00 Room: F1 + F2

International Psoriasis Council – The mechanistic model(s) of psoriasis: Autoimmune and/or autoinflammatory?

This symposium will explore recent advances in the understanding of both the adaptive and innate immune pathways that lead to clinical phenotypes of psoriasis. Part 1 of this event will feature five faculty presentations with expert panel discussion on the immunological spectrum of psoriasis whereby the adaptive immune response drives chronic plaque psoriasis and innate and autoinflammatory responses contribute to rare subtypes of psoriasis. The complex interplay among autoreactive T-cells, lipid driven T cell response, cytokines, and genetic mutations will be highlighted.

Chairs Michel Gilliet Lausanne, Switzerland)Johann Gudjonsson (Michigan, United States)Jörg Prinz (Munich, Germany)

Program14.00–14.05 Welcome and Overview

Michel Gilliet (Lausanne)

PART I: LECTURES

14.05–14.30 Autoreactive T cells in psoriasisJörg Prinz (Munich)

14.30–14.55 Lipid driven T cell responses in psoriasisChyung-Ru Wang (Chicago, USA)

14.55–15.20 The role of self in the innate immune systemMichel Gilliet (Lausanne)

15.20–15.35 Break

15.35–16.00 The role of interleukin-36 pathway deregulation in pustular psoriasis and psoriasis vulgaris: the autoinflammatory side of psoriasisHervé Bachelez (Paris)

16.00–16.25 The impact of AP1S3 and CARD14 deregulation in psoriasis and psoriasis-like disordersFrancesca Capon (London)

16.25–16.55 Panel DiscussionModerator: Johann Gudjonsson (Michigan, United States)

34

Part II: POSTERS

16.55–17.05 Poster 388 Treatment with spesolimab, an anti-interleukin-36 receptor antibody, in patients with generalized pustular psoriasis, is associated with the downregulation of biomarkers linked to innate, Th1/17 and neutrophilic pathwaysChristian Thoma (Biberach)

17.05–17.15 Poster 281 CARD14 variants are associated with palmar plantar pustulosisAthanasios Niaouris (London)

17.15–17.25 Poster 340 Circulating microRNAs in extracellular vesicles from plasma as potential biomarkers for psoriatic arthritis in patients with psoriasisLorenzo Pasquali (Stockholm)

17.25–17.35 Poster 054 A Selective Tyrosine Kinase 2 Inhibitor, BMS-986165, Decreases the Transcriptional Signature of Th17, Interleukin-12, and Interferon Pathways in Skin of Psoriasis: Results From a Phase 2 TrialIan Catlett (Princeton, USA)

17.35–17.45 Poster 399 Distinct gene expression signatures differentiate clinical response to ustekinumab compared to adalimumab in psoriasisAshley Rider (Newcastle Upon Tyne)

17.45–17.55 Poster 360 miR-378a is overexpressed in psoriasis keratinocytes and potentiates IL-17A-mediated inflammatory responsesEnikö Pivarcsi Sonkoly (Stockholm)

17.55–18.00 Closing CommentsJörg Prinz (Munich)

49TH

Thursday 19 September 2019

36

Thursday19Thursday 19 September 2019


08:30–10:15 Drug Discovery and Translational Medicine Amphitheatre A

08:30–10:30 Eastern European Research Amphitheatre B

08:30–10:30 Neurobiology of the Skin Amphitheatre C

10:30–11:00 Coffee Break

11:00–11:10 Opening Ceremony Amphitheatre A


13:00–14:30 Epithelial Barrier Dysfunction in Type 2 Inflammatory Diseases Amphitheatre A

13:00–14:30 PPARs as Conductors of the Skin Orchestra in Health in Disease Amphitheatre B

13:00–14:00 Chronic Inflammatory Diseases: from Immunology to Personalized Medicine Amphitheatre C

14:40–16:10 Concurrent Session 1: Adaptive Immunity and Autoimmunity Amphitheatre A

14:40–16:10 Concurrent Session 2: Photobiology and Pigmentation E1 + E2

14:40–16:10 Concurrent Session 3: Epidermal Structure and Function Amphitheatre C

14:40–16:10 Concurrent Session 4: Genetics, Cell Based Therapy and Wound Healing Amphitheatre B

16:25–16:55 Rudi Cormane Lecture: Nick Reynolds Amphitheatre A

17:00–18:00 General Poster Session 1 Foyer – Poster Area

18:05–18:20 Intersociety Collegiality Awards Amphitheatre A

18:20–18:50 Special Guest Lecture: Pier-Vincenzo Piazza Amphitheatre A

18:50–21:15 Welcome Reception Foyer – Exhibition/Poster Area

37

Thursday19 Thursday 19 September 201908.30–10.15 Room: Amphitheatre A

Drug Discovery and Translational MedicineChairs: Sabine Eming (Cologne), Chris Griffiths (Manchester)

This session is supported by an educational grant from Lilly


Chris Griffiths (Manchester, United Kingdom)

08.35–08.55 Challenges in drug discovery: the yin and yang of the academia and industry Elisabeth Riedl (Vienna, Austria)

08.55–09.15 Antifibrotic approaches for symptom-relief therapy for epidermolysis bullosa Leena Bruckner-Tuderman (Freiburg, Germany)

09.15–09.35 Translational Dermatology Menno de Rie (Amsterdam, The Netherlands)

09.35–09.55 Panel Discussion

09.55–10.00 Closing Remarks Sabine Eming (Cologne, Germany)

10.00–10.05 ESDR 2019 Lilly Scholarships David Kelsell (London, UK)

10.05–10.15 Group Photo of Scholarship Awardees

38

ThursdayThursday 19 September 201908.30–10.30 Room: Amphitheatre B

Eastern European ResearchChair: Marta Szell (Szeged, Hungary)

Program08.30–08.40 Welcome and Awards

Marta Szell (Szeged, Hungary)

08.40–09.00 Lecture of the Academic Leader award winner 2019 The function and therapeutic potential of miRNAs in inflammatory skin diseases Ana Rebane (Tartu, Estonia)

09.00–09.10 Poster 231 The potential role of VDR and its coactivators in the regulation of skin analogue HPA axis expression in keratinocytes JM Wierzbicka (Gdansk, Poland)

09.10–09.20 Poster 238 Ligands of aryl-hydrocarbon receptor regulate its stability in ARNT-dependent mannerSG Rudyak (Moscow, Russian Federation)

09.20–09.30 Poster 379 Characterizing the Role of PLCg2 in Autoantibody-induced Skin Inflammation K Szilveszter (Budapest, Hungary)

09.30–09.40 Poster 118 Altered intestinal barrier in psoriasis is associated with disease severity, gastrointestinal symptoms and presence of bacteria metabolites in the blood M Sikora (Warsaw, Poland)

09.40–09.50 Poster 410 Cartilage oligomeric matrix protein (COMP) negatively influences keratinocyte proliferation via a5b1-integrin: Potential relevance of altered COMP expression in psoriasis R Bozo (Szeged, Hungary)

09.50–10.00 Poster 273 IQGAP proteins in psoriasis: is it only about scaffold? A Zolotarenko (Moscow, Russian Federation)

10.00–10.10 Poster 224 Revealing Barrier Alterations in Rosacea Skin at the Molecular Level Z Dajnoki (Debrecen, Hungary)

10.10–10.20 Poster 499 miR-204–5p modulators application in vitro and in vivo in melanoma cells T Ruksha (Krasnoyarsk, Russian Federation)

10.20–10.30 Poster 406 TRPV4 stimulates differentiation of monocyte derived Langerhans cells without influencing their maturation S Alimohammadi (Szeged, Hungary)

10.30 Closing Remarks Marta Szell (Szeged, Hungary)

39

ThursdayThursday 19 September 201908.30–10.30 Room: Amphitheatre C

Neurobiology of the SkinChairs: Anna Zalewska (Lodz, Poland), Marcus Maurer (Berlin, Germany)

Program08.30–08.35 Welcome and introduction

Anna Zalewska (Lodz, Poland)

08.35–08.50 Synapses between neurons and keratinocytes Matthieu Talagas (Brest, France)

08.50–09.05 CLA+ T cells in the nervous-immune interaction in human skin Luis F Santamaria-Babi (Barcelona, Spain)

09.05–09.20 Aberrations of the nerve – sweat gland interactions in cholinergic urticaria Sabine Altrichter (Berlin, Germany)

09.20–09.35 Neurokinin 1 receptor antagonism reveals peripheral effects in prurigo nodularis Konstantin Agelopoulos (Muenster, Germany)

09.35–09.50 Atopic dermatitis and stress Klas Nordlind (Stockholm, Sweden)

09.50–10.05 Neuroinflammation: a promising target for the treatment of inflammatory skin diseases Thomas Luger (Muenster, Germany)

10.05–10.20 Olfactory receptors of human hair follicles: What are they doing, and what are they “smelling”? Ralf Paus (Miami, USA and Manchester, UK)

10.20–10.30 Summary and Conclusions Marcus Maurer (Berlin, Germany)

Notes

40

ThursdayThursday 19 September 201911.15–12.55 Room: Amphitheatre A

Frontiers in Skin Biology & Dermatology 1 & Plenary Session 1Chairs: Chris Griffiths, Caterina Missero

Plenary presentations are 8 minutes plus 2 minutes discussion

Program11.15–11.40 Frontiers Lecture

Gene editing for therapy of inherited skin diseases Julia Reichelt (Salzburg, Austria)

11.40–11.50 001 (Poster 431) Innate lymphoid cells type 1 may be new, non-antigen-specific player in the pathogenesis of alopecia areata Rima Laufer,1 Aviad Keren,1 Ralf Paus,2,3 Amos Gilhar1

1Skin Research laboratory, Haifa, Israel, 2University of Miami, Miami, Florida, United States, 3University of Manchester, Manchester, United Kingdom

11.50–12.00 002 (Poster 404) The collagen network maintained by macrophages provides a niche for Staphylococcus aureus skin infection Benjamin Voisin, Thomas Doebel, Jay Hyun Jo, Vinod Nadella, Tetsuro Kobayashi, Doyoung Kim, Heidi Kong, Keisuke Nagao National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health, Bethesda, Maryland, United States

12.00–12.10 003 (Poster 421) Langerin-specific aryl hydrocarbon deficiency diminishes epidermal Langerhans cells and leads to enhance atopic Th2 responses Chih-Hung Lee,1,2 Shang-Hung Lin,1,2 Chien-Hui Hong3,4

1Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, 2Dermatology, Chang Gung University, Taoyuan, Taiwan, 3Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 4Dermatology, National Yang Ming University, Taipei, Taiwan

12.10–12.20 004 (Poster 261) Nucleocytoplasmic shuttling of iRHOM2 and its regulation of epidermal differentiation Anissa Chikh,1 Catherine M. Webb,1 Paola Arcidiacono,1 Ryan Pink,2 David P. Kelsell1 1Cell Biology&Cutaneous research, Blizard Institute, Queen Mary University of London, London, United Kingdom, 2Oxford Brookes University, Oxford, United Kingdom

12.20–12.30 005 (Poster 572) Epidermal stem cell competition orchestrates skin organ homeostasis and aging Nan Liu,1 Hiroyuki Matsumura,1 Tomoki Kato,1 Shizuko Ichinose,2 Aki Takada,1 Takeshi Namiki,3 Kyosuke Asakawa,1 Hironobu Morinaga,1 Yasuaki Mohri,1 Adèle Arcangelis,4 Elisabeth Georges-Labouesse,4 Daisuke Nanba,1 Emi K. Nishimura1 1Department of Stem cell medicine, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-Ku, Tokyo, Japan, 2Division of Human Gene Sciences Research, Research Center for Medical and Dental Sciences, Tokyo M edical and Dental University, Bunkyo-Ku, Japan, 3Department of Dermatology, Tokyo Medical and Dental University Graduate School and Faculty of Medicine, Bunkyo-ku, Tokyo, Japan, 4Development and Stem Cells Department, Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, Strasbourg, France

12.30–12.55 Frontiers Lecture A novel non-monocytic macrophage precursor Wolfgang P. Weninger (Vienna, Austria)

41

ThursdayThursday 19 September 201913.00–14.30 Room: Amphitheatre A

Sanofi Symposium – Epithelial Barrier Dysfunction in Type 2 Inflammatory Diseases

Program13.00–13.05 Opening

Ignacio Dávila (Salamanca, Spain)

13.05–13.25 The immunology of type 2 inflammation Ignacio Dávila (Salamanca, Spain)

13.25–13.45 Epithelial barrier dysfunction and type 2 inflammation in Atopic Dermatitis Julien Seneschal (Bordeaux, France)

13.45–14.05 Epithelial barrier dysfunction and type 2 inflammation in Asthma Sven-Erik Dahlén (Stockholm, Sweden)

14.05–14.25 Knowledge gaps in type 2 inflammatory diseases Panel Discussion

14.25–14.30 Conclusions Ignacio Dávila (Salamanca, Spain)

Notes

42


Nogra Pharma Symposium – PPARs as Conductors of the Skin Orchestra in Health in DiseaseChairs: Prof. Mauro Picardo (Rome, Italy), Prof. Christos Zouboulis (Dessau, Germany) Discussant: Prof Michel Gilliet (Lausanne, Switzerland)

Program13.00–13.15 PPARy in skin inflammation

Christos Zouboulis (Dessau, Germany)

13.15–13.30 PPARy signaling a key mediator of human hair follicle physiology and pathology Ralf Paus (Manchester, United Kingdom)

13.30–13.45 PPARy in barrier homeostasis Matthias Schmuth (Innsbruck, Austria)

13.45–14.00 PPARy regulates skin-tropic Th2 cells Christoph Schlapbach (Bern, Switzerland)

14.00–14.15 PPARy modulation in clinical research Mauro Picardo (Rome, Italy)

14.15–14.30 General Discussion

Notes

43


Novartis Symposium – Chronic Inflammatory Diseases: from Immunology to Personalized MedicineModerator: Prof Thierry Passeron (Nice, France)

Program13.00–13.10 Welcome & Introduction

Thierry Passeron (Nice, France)

13.10–13.25 New treatment paradigm: one pathway / multiple diseases Thierry Passeron (Nice, France)

13.25–13.40 Linking pathophysiology to clinical evidence: integrated vision of immunologic aspects regarding T lymphocyte memory Marc Vocanson (Lyon, France)

13.40–13.55 How P4 medicine will transform dermatological care Christopher Griffiths (Manchester, UK)

13.55–14.00 Conclusions & Closing statement Thierry Passeron (Nice, France)

Notes

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ThursdayThursday 19 September 2019 14.40–16.10 Room: Amphitheatre A

Concurrent Session 1 – Adaptive Immunity and AutoimmunityChairs: Sara Brown, Bernhard Homey

Concurrent presentations are 8 minutes plus 2 minutes discussion

Program14.40–14.50 012 (Poster 028) The activation status of nuclear factor κB in type 2 conventional dendritic cells before

therapy correlates with clinical response to adalimumab R Andres Ejarque, P Di Meglio and o PSORT Consortium King’s College London, London, United Kingdom

14.50–15.00 013 (Poster 006) Skin dendritic cells progressively subvert the activation of pathogenic Type-2 immunity upon epicutaneous allergen immunotherapy L Laoubi,1,2 H Sampson,2 L Mondoulet,2 J Nicolas,1 V Dioszeghy2 and M Vocanson1 1CIRI - INSERM U1111, ENS de Lyon, UCBL1, CNRS UMR 5308, Lyon, France and 2DBV Technologies, Montrouge, France

15.00–15.10 014 (Poster 017) Tc2 induction of IL-10-producing plasmablasts during contact hypersensitivity Y Matsumura,2 R Watanabe,2 H Koguchi-Yoshioka,2 S Vo1 and M Fujimoto1 1Dermatology, Graduate school of Medicine, Osaka University, Osaka, Japan and 2Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

15.10–15.20 015 (Poster 029) The IL-31-producing circulating T cells subset represents a unique population of CLA+ CRTH2+ CCR4+ effector memory T cells A Datsi,1 K Raba,3 S Kellermann,1 A van Lierop,1 P Olah,1,2 R Sorg3 and B Homey1 1Department of Dermatology, University of Duesseldorf, Duesseldorf, Germany, 2Dermatology, University of Pécs, Pécs, Hungary and 3Institute of Transplantation Diagnostics and Cell Therapeutics, University of Duesseldorf, Duesseldorf, Germany

15.20–15.30 016 (Poster 009) Real-time in vivo imaging of CD8+ T cell-mediated keratinocyte apoptosis in a graft versus host disease-like murine model H Cheng,1,2 T Honda,2 J Sakabe,3 Y Tokura,3 and K Kabashima2 1National Skin Centre, Singapore, Singapore, 2Dermatology, Kyoto University, Kyoto, Japan and 3Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan

15.30–15.40 017 (Poster 031) Development of a mouse model of Pemphigus Vulgaris as a tool to evaluate nanoparticle induced antigen-specific tolerance C Hudemann,1 R Pollmann,1 M Hertl,1 S Fleischer2 and R Eming1 1Department of Dermatology and Allergology, Philipps-University Marburg, Marburg, Germany and 2Topas Therapeutics GmbH, Hamburg, Germany

15.40–15.50 018 (Poster 008) PPARγ regulates IL-9 expression in human TH2 cells by promoting glycolysis L von Meyenn,1 O Steck,1 O Friedli,2 N Bertschi,1 S Freigang2 and C Schlapbach1 1Department of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland and 2Institute of Pathology, University of Bern, Bern, Switzerland

15.50–16.00 019 (Poster 022) Crosstalk between vitiligo skin T-cell secretome and epidermal cell response C Martins,1 C Drullion,1 L Migayron,1 C Jacquemin,1 F Lucchese,1 A Taieb,1,2 J Seneschal1,2 and K Boniface1 1University of Bordeaux, Bordeaux, France and 2Bordeaux Hospital, Bordeaux, France

16.00–16.10 020 (Poster 024) Downregulated expression of Interferon regulatory factor 8 in monocytes/macrophages exhibits pro-fibrotic phenotype and may contribute to the pathogenic process of systemic sclerosis Y Ototake,1 Y Yamaguchi,1 M Asami,1 N Komitsu,1 T Watanabe,1 D Kurotaki,2 T Tamura2 and M Aihara1 1Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan and 2Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan

45

ThursdayThursday 19 September 201914.40–16.10 Room: E1+E2

Concurrent Session 2 – Photobiology and PigmentationChairs: Julien Seneschal, Rachel Watson


Program14.40–14.50 021 (Poster 524) Melanin localisation and transport in the human epidermis

I Castellano Pellicena,2 C O’Connor,1 M Bell1 and DJ Tobin2 1Walgreens Boots Alliance, Nottingham, United Kingdom and 2The Charles Institute of Dermatology, UCD, Dublin, Ireland

14.50–15.00 022 (Poster 525) Identification of a new gene involved in human skin pigmentation: CLEC12B L Sormani Le Bourhis,1,3 H Taquin,2,3 R Mhaidly,3 M Heim,2 M Tulic,1 H Montaudie,2 S Rocchi1,3 and T Passeron1,2,3 1INSERM, Nice, France, 2Department of Dermatology, CHU Nice, Nice, France and 3Université Côte d’Azur, Nice, France

15.00–15.10 023 (Poster 526) Autophagy is an adaptive stress response in Vitiligo E Bastonini, D Kovacs, P Iacovelli, A Pacifico and M Picardo San Gallicano Dermatological Institute, IRCCS, Rome, Italy

15.10–15.20 024 (Poster 533) Type-1 cytokines induce depigmentation through JAK/STAT signaling, MMP9 production and disruption of E-cadherin expression N Boukhedouni,1 C Martins,1 C Drullion,1 J Garnier,2 C Barrault,2 J Rambert,3,1 A Taieb,1,4 F Bernard,2 J Seneschal1,4 and K Boniface1 1University of Bordeaux, Bordeaux, France, 2Bioalternatives, Gençay, France, 3Aquiderm, Bordeaux, France and 4Bordeaux Hospital, Bordeaux, France

15.20–15.30 025 (Poster 534) Antibiotics modify outcomes in vitiligo P Cosgrove,1 ER Dellacecca,4 S Akhtar,3 VH Engelhard,4 KL Knight5and IC Le Poole1,2 1Dermatology, Northwestern University, Chicago, IL, 2Microbiology and Immunology, Northwestern University, Chicago, IL, 3Pediatrics, Northwestern University, Chicago, IL, 4Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA and 5Microbiology and Immunology, Loyola University, Maywood, IL

15.30–15.40 026 (Poster 530) Local inhibition of MEK/AKT prevents cellular growth in human congenital melanocytic nevi T Rouillé,1 S Aractingi,1,2 N Kadlub,5 S Fraitag,4 A How-Kit,6 P Moguelet,3 A Picard,5 R Fontaine1 and S Guégan1,2 1INSERM UMR_S 938, CDR Saint-Antoine, Sorbonne Université, Paris, France, 2Dermatology, Hôpital COCHIN, Université Paris Descartes, Paris, France, 3Pathology, Hôpital Tenon, AP-HP, Paris, France, 4Pathology, Hôpital Necker- Enfants-Malades, AP-HP, Paris, France, 5Maxillofacial and plastic surgery, Hôpital Necker- Enfants-Malades, AP-HP, Paris, France and 6Laboratory for Functional Genomics, Fondation Jean Dausset – CEPH, Paris, France

15.40–15.50 027 (Poster 538) Acute UVR exposure has prolonged impact on eicosanoid and immune profile of healthy human skin in vivo: Implications for resolution biology N Hawkshaw, S Pilkington, S Murphy, A Kendall, RE Watson, A Nicolaou and LE Rhodes University of Manchester, Manchester, United Kingdom

15.50–16.00 028 (Poster 532) Role of apoptosis and key canonical pathways in psoriasis plaque clearance in response to UVB phototherapy R Roberts,1 S Weatherhead,2 S Cockell1 and N Reynolds1 1Newcastle University, Newcastle, United Kingdom and 2RVI, Newcastle, United Kingdom

16.00–16.10 029 (Poster 527) Keratinocyte-Specific Function of Hypoxia-Inducible Factor-1alpha (HIF1a) in UVB-Induced Immunosuppression S Fassbender,1,2 M Majora,1 I Foerster,2 J Krutmann1 and H Weighardt2 1IUF - Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany and 2LIMES Life and Medical Sciences Institute, Bonn, Germany

46


Concurrent Session 3 – Epidermal Structure and FunctionChairs: Leopold Eckhart, Matthias Schmuth


Program14.40–14.50 030 (Poster 235) PPAR-alpha deficiency drives altered bacterial skin colonization and abnormal eicosanoid

skin composition S Blunder,1 R Ruhl,2 D Orth-Höller3 and S Dubrac1 1Department of Dermatology, Venereology and Allergology, Innsbruck, Austria, 2Paprika Bioanalytics BT, Debrecen, Hungary and 3Department of Hygiene and Medical Bacteriology, Medical University of Innsbruck, Innsbruck, Austria

14.50–15.00 031 (Poster 189) STAT1 gain-of-function compromises skin host defense in the context of IFN-γ signaling H Niehues,1,2 B Rösler,3 D van der Krieken,1 I van Vlijmen-Willems,1 D Rodijk-Olthuis,1 M Peppelman,1 J Schalkwijk,1 P Zeeuwen,1,2 E van den Bogaard1,2 and F van de Veerdonk3 1Dermatology, Radboud University Medical Center, Nijmegen, Netherlands, 2Radboud Institute for Molecular Life Sciences, Nijmegen, Netherlands and 3Department of Internal Medicine, Radboudumc, Nijmegen, Netherlands

15.00–15.10 032 (Poster 194) A CRISPR-interference screen identifies PRANCR and other novel long non-coding RNAs controlling human epidermis formation A Otten,1 P Cai,2 B Cheng,1 M Ishii,1 K Qu2 and B Sun1 1Dermatology, University of California, San Diego, La Jolla, CA and 2School of Life Sciences, University of Science and Technology of China, Hefei, China

15.10–15.20 033 (Poster 274) Junctional epidermolysis bullosa: bottom up control of the skin barrier? EM Jones,1 S Marsh,1 RF O’Shaughnessy,1 E Camera,2 M Picardo,2 M Aumailley,3 E O’Toole1 and M Caley1 1Centre for Cutaneous Research, Blizard Institute, QMUL, London, United Kingdom, 2Istituto Dermatologico San Gallicano, Rome, Italy and 3Centre for Biochemistry, University of Cologne, Cologne, Germany

15.20–15.30 034 (Poster 239) Desmosomes pattern cell mechanics to govern epidermal tissue form and function JA Broussard, JL Koetsier and KJ Green Northwestern University, Chicago, IL

15.30–15.40 035 (Poster 268) Geometry-dependent chromatin remodelling in keratinocytes is altered by cell-cell adhesions LM Blowes, K Sliogeryte, N Gavara and J Connelly Queen Mary University of London, London, United Kingdom

15.40–15.50 036 (Poster 255) Palmoplantar skin and keratinocytes harbouring mutant AQP5 display dysregulated actin cytoskeleton D Blaydon and DP Kelsell Centre for Cell Biology and Cutaneous Research, Blizard Institute, QMUL, London, United Kingdom

15.50–16.00 037 (Poster 240) SerpinB12 is an intrinsic mesotrypsin inhibitor regulating corneocyte desquamation and enucleation M Miyai,1 J Hiruma,2 A Motoyama,1 M Egawa,1 M Yamamoto,2 Y Ozeki,3 R Tsuboi2 and T Hibino1,2 1Global Innovation Center, Shiseido, Yokohama, Kanagawa, Japan, 2Dermatology, Tokyo Medical University, Tokyo, Japan and 3Graduate School of Engineering, The University of Tokyo, Tokyo, Japan

16.00–16.10 038 (Poster 246) Nuclear destruction during epidermal terminal differentiation requires actin cytoskeletonmediated nuclear lamin dispersal and rapid nuclear volume reduction C Rogerson and RF O’Shaughnessy Blizard Institute, Queen Mary University of London, London, United Kingdom

47


Concurrent Session 4 – Genetics, Cell Based Therapy and Wound HealingChairs: Eli Sprecher, Marta Szell


Program14.40–14.50 039 (Poster 283) Genome-wide association study in frontal fibrosing alopecia identifies 4 genomic loci

and implicates auto-immunity and xenobiotic exposure in aetiopathogenesis C Tziotzios,1 C Petridis,2 N Dand,2 J Saklatvala,2 V Pullabhatla,3 CM Stefanato,1 DA Fenton,1 MA Simpson2 and JA McGrath1 1St John’s Institute of Dermatology, King’s College London, London, United Kingdom, 2Department of Medical Genetics, King’s College London, London, United Kingdom and 3UK NIHR GSTFT/KCL Comprehensive Biomedical Research Centre, London, United Kingdom

14.50–15.00 040 (Poster 284) Deciphering the pathogenesis of central centrifugal cicatricial alopecia L Malki,1 O Sarig,1 MT Romano,2 MC Mechin,3 N Shomron,4 M Simon,3 A McMichael,5 N Dlova,6 RC Betz2 and E Sprecher1 1Dermatology, Tel-Aviv Sourasky medical center, Tel Aviv, Israel, 2Institute of Human Genetics, University of Bonn, Bonn, Germany, 3INSERM U1056, University of Toulouse III, Toulouse, France, 4Tel Aviv University, Tel Aviv, Israel, 5Wake Forest Baptist Medical Center, Winston-Salem, NC and 6University of KwaZulu– Natal, Durban, South Africa

15.00–15.10 041 (Poster 280) Transcription termination modulates human epidermal proliferation and differentiation X Chen,1 S Lloyd,1 J Kweon,1 G Gamalong1 and X Bao1,2 1Molecular Biosciences, Northwestern University, Evanston, IL and 2Dermatology, Northwestern University, Chicago, IL, USA

15.10–15.20 042 (Poster 279) Keratinocyte specific biallelic mutations in mevalonate pathway genes due to postzygotic second hits drive linear and disseminated superficial actinic porokeratosis A Kubo,1 T Sasaki,2 H Suzuki,3 A Shiohama,1 S Aoki,1 T Kawai,4 K Nakabayashi,4 K Hata,4 K Kosaki3 and M Amagai1 1Dermatology, Keio Univ, Tokyo, Japan, 2Center for Supercentenarian Medical Research, Keio Univ, Tokyo, Japan, 3Center for Medical Genetics, Keio Univ, Tokyo, Japan and 4National Center for Child Health and Development, Tokyo, Japan

15.20–15.30 043 (Poster 625) Fibroblast-specific overexpression of collagen XII leads to a delay in skin repair K Schönborn,1 S Willenborg,2 J Schulz,2 F Quondamatteo,3 S Eming,2 A Niehoff,4 T Imhoff,5 M Koch,5 T Krieg1 and B Eckes1 1Translational Matrix Biology, University of Cologne, Köln, Germany, 2Dermatology, University of Cologne, Cologne, Germany, 3Anatomy, University of Glasgow, Glasgow, United Kingdom, 4Biomechanics, University of Cologne, Cologne, Germany and 5Oral Musculoskeletal Biology, University of Cologne, Cologne, Germany

15.30–15.40 044 (Poster 623) Changing endothelial cell fate in wound healing through modulation of Sox9 to reduce scarring J Patel, H Hamilton, S Kahler, S Sim, H Wong and K Khosrotehrani Diamantina Institute, University of Queensland, Brisbane, QLD, Australia

15.40–15.50 045 (Poster 624) Myeloid cell-specific Fli1 knockout mice exhibit systemic sclerosis-like vasculopathy and delayed wound healing due to impaired vasculogenesis Y Fukui, T Miyagawa, M Hirabayashi, K Nakamura, J Omatsu, S Toyama, A Yoshizaki, S Sato and Y Asano Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

15.50–16.00 046 (Poster 629) The ATP-dependent chromatin remodeler BRG1 controls epidermal keratinocytes migration during human cutaneous wound healing C Kellett,1 R Bhogal,2 N Botchkareva1 and M Fessing1 1Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom and 2Global Research and Development Centre, Unilever, Sharnbrook, United Kingdom

16.00–16.10 047 (Poster 578) Immunometabolic imbalance fosters skin ageing E Carrasco,1,2,3 G Soto-Heredero,1,2,3 E Blanco3,2 and M Mittelbrunn3,1,2 1Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid, Madrid, Spain, 2Cell Biology and Immunology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain and 3Rare and Genetically Based Diseases, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain

48

Thursday 19 September 201917.00–18.00 Room: Poster Area

General poster session All authors to stand by their posters.

Thursday 19 September 2019 18.05–18.20 Room: Amphitheatre A

JSID, KSID and SID Intersociety Collegiality AwardsAward ceremonies for recipients of collegiality awards from JSID, KSID and SID.

Thursday 19 September 2019 18.50–21.15 Room: Foyer

2019 Welcome Reception The Welcome Reception is open to all registered delegates.

Notes

Thursday

49


2019 Rudi Cormane Lecture

Nick Reynolds (Newcastle upon Tyne, UK)

A systems biology and computational modelling approach to inflammatory skin disease

Introduced by: David Kelsell

About The Rudi Cormane Lecture is a special lecture within the ESDR annual meeting and is awarded to an internationally renowned scientist who has also made a significant contribution to the ESDR.

This lectureship is named after the late Prof Rudi Cormane, a distinguished innovator and educator and one of the founders of the ESDR in 1970. Rudi Cormane was Treasurer of the ESDR from 1971–1974 and President in 1975.

Past Lecturers Tilo Biedermann, Masayuki Amagai, Carien Niessen, Alexander Enk, Vincent Piguet, John McGrath, Martin Röcken, Martine Bagot, Thomas Schwarz, Lars French, Leena Bruckner-Tuderman, Michael Detmar, Jonathan Rees, John Voorhees, Jens Schröder, Irene Leigh, Conrad Hauser, Thomas Luger, Enno Christophers, Jean-Paul Ortonne, Gerhold Schuler, Thomas Krieg.


Special Guest Lecture

Pier-Vincenzo Piazza (Bordeaux, France)

Signaling specific inhibitor of the CB1 receptor a new class of disease specific drugs

Introduced by: Alain Taïeb

We are pleased to feature a special lecture from a prominent academic outside of skin research. We hope this lecture will create talking points throughout the annual meeting.

Thursday

Targeting extracellular in�ammatory mediators or intracellular pathways for dermatological diseases:Which is better?

Friday 20 September13:00–14:30 Amphitheatre A

Agenda

Opening statementProfessor Errol Prens (Chair), The Netherlands

Focus on: PsoriasisAssociate Professor Curdin Conrad, Switzerland

Focus on: Atopic dermatitisProfessor Nick Reynolds, UK

Focus on: Hidradenitis suppurativaProfessor Errol Prens

Closing statement Professor Errol Prens

PM-GII-OTZ-0034September 2019

A Celgene-sponsored symposium at ESDR 2019

49TH

Friday 20 September 2019

Targeting extracellular in�ammatory mediators or intracellular pathways for dermatological diseases:Which is better?

Friday 20 September13:00–14:30 Amphitheatre A

Agenda

Opening statementProfessor Errol Prens (Chair), The Netherlands

Focus on: PsoriasisAssociate Professor Curdin Conrad, Switzerland

Focus on: Atopic dermatitisProfessor Nick Reynolds, UK

Focus on: Hidradenitis suppurativaProfessor Errol Prens

Closing statement Professor Errol Prens

PM-GII-OTZ-0034September 2019

A Celgene-sponsored symposium at ESDR 2019

52

Friday 20 September 2019


08:30–09:30 A New Treatment Option for Patients with Moderate to Severe Atopic Dermatitis: Targeting the IL-31/IL-31R Signaling Pathway

Amphitheatre A

08:30–09:30 A Deep Dive into Chlormethine Gel: from Bench to Patients Amphitheatre B

08:30–09:30 Immunoglobulin Therapy in Severe Autoimmune Skin Diseases Amphitheatre C

09:35–10:05 Celgene ESDR Guest Lecture: Arturo Zychlinsky Amphitheatre A


11:55–12:55 Poster Walks (01–10) and Poster Viewing (Odd numbers) Foyer + Poster Area

13:00–14:30 Targeting Extracellular Inflammatory Mediators or Intracellular Pathways for Dermatological diseases: Which is Better?

Amphitheatre A

13:00–14:30 Senescence & Skin Aging Amphitheatre C

13:00–14:30 Pathways to Silencing Psoriasis: Remission or Cure? Amphitheatre B

14:40–15:10 ESDR Guest Lecture: David E. Fisher Amphitheatre A

15:20–16:20 Poster Walks (11–20) and Poster Viewing (EVEN NUMBERS) Foyer + Poster Area

16:45–17:15 René Touraine Lecture: Marja Mikkola Amphitheatre A

17:20–17:35 ESDR Honorary Membership Awards Amphitheatre A

17:40–18:30 ESDR Annual General Meeting of Members Amphitheatre A

19:30–00:00 Social Networking Event Palais de la Bourse

Friday20

53

Friday 20 September 201908.30–09.30 Room: Amphitheatre A

Galderma Symposium – A New Treatment Option for Patients with Moderate to Severe Atopic Dermatitis: Targeting the IL-31/IL-31R Signaling PathwayChair: Alain Taïeb (Bordeaux, France)

Symposium summaryChair Professor Alain Taïeb will be joined by Professors Marjolein de Bruin Weller, Bernhard Homey, and Jean-David Bouaziz for this Galderma-sponsored educational symposium exploring the role of IL-31/IL-31R in the pathogenesis of atopic dermatitis, and the therapeutic potential of blocking this signaling pathway. Many patients with moderate-to-severe atopic dermatitis have a high disease burden, and continue to experience symptoms and reduced quality of life despite treatment. Therefore, there remains an unmet need for new treatment options for patients whose disease is not adequately controlled by currently available therapies. The IL-31/IL-31R signaling pathway represents a promising novel therapeutic target for these patients.


Alain Taïeb (Bordeaux, France)

08.32–08.50 Are patient needs being met? Marjolein de Bruin-Weller (Utrecht, The Netherlands)

08.50–09.08 IL-31/IL-31R: Inflammation, nerves, and the skin barrier – implications for pathophysiology of atopic dermatitis Bernhard Homey (Dusseldorf, Germany)

09.08–09.26 Clinical perspectives in moderate-to-severe atopic dermatitis: Targeting IL-31/IL-31R Jean-David Bouaziz (Paris, France)

09.26–09.30 Summary and close Alain Taïeb (Bordeaux, France)

Friday20

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FridayFriday 20 September 201908.30–09.30 Room: Amphitheatre B

Helsinnrecordati Symposium – A Deep Dive into Chlormethine Gel: from Bench to PatientsChairs: Emmanuella Guenova (Zurich, Switzerland) Brian Poligone (Fairport, NY, USA)

Program08.30–08.35 Opening and welcome

Emmanuella Guenova (Switzerland)

08.35–09.00 Chlormethine gel: exploring the mechanism of action Emmanuella Guenova (Switzerland)

09.00–09.25 Dermatitis management and chlormethine gel: new key learning points Brian Poligone (USA)

09.25–09.30 Summary and closing Emmanuella Guenova (Switzerland) and Brian Poligone (USA)

Notes

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FridayFriday 20 September 201908.30–09.30 Room: Amphitheatre C

Biotest Symposium – Immunoglobulin Therapy in Severe Autoimmune Skin DiseasesChair: Alexander Enk (Heidelberg, Germany)

Program08.30–08.50 IVIG therapy: why, when and where it is useful?

Alexander Enk (Heidelberg, Germany)

08.50–09.10 The mode of action of IVIG in mucous membrane pemphigoid Christian Sadik (Lubeck, Germany)

09.10–09.30 How do high-dose intravenous immunoglobulins act on antibody formation in a mouse model of pemphigus vulgaris? Rudiger Eming (Marburg, Germany)

Notes

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FridayFriday 20 September 201910.05–11.45 Room: Amphitheatre A

Frontiers in Skin Biology & Dermatology 2 & Plenary Session 2Chairs: Katia Boniface, Christoph Schlapbach

Frontiers in Skin Biology & Dermatology 2 is supported by:


Program10.05–10.30 Frontiers Lecture Discovering and targeting cell subpopulations

in zebrafish development and melanoma Liz Patton (Edinburgh, UK)

10.30–10.40 006 (Poster 298) Defective DNA Repair and Chromosomal Instability in RDEB Matthew Caley,1 Supatra Marsh,1 Vera L. Martins,1 Tania Corbett-Jones,2 Mei Chen,3 Wei-Li Di,4 Denise Sheer,2 John A. McGrath,5 Michael Barnes,6 Edel O'Toole1 1Centre for Cutaneous Research, Blizard Institute QMUL, Whitechapel, United Kingdom, United Kingdom, 2Genomics and Child Health, QMUL, London, United Kingdom, 3Keck School of Medicine, USC, LA, California, United States, 4GOS Institute of Child Health, UCL, London, United Kingdom, 5St John’s Institute of Dermatology, KCL, London, United Kingdom, 6WHRI, QMUL, London, United Kingdom

10.40–10.50 007 (Poster 336) Mutualistic skin bacteria protect against dermatitis via the induction of steroid biosynthesis pathways Yoshihiro Ito,1 Takashi Sasaki,2 Eiryo Kawakami,3 Wataru Suda,4 Koji Atarashi,1 Masayuki Amagai,1 Kenya Honda,1 1Keio Univ., RIKEN-IMS, Yokohama, Japan, 2Keio Univ., Tokyo, Japan, 3RIKEN-MIH, Yokohama, Japan, 4RIKEN-IMS, Yokohama, Japan

10.50–11.00 008 (Poster 325) E3 ligase Trim21 ubiquitylates NF-κB p65 subunit and promotes inflammation in psoriatic keratinocytes Luting Yang, Jiahong Wu, Tongmei Zhang, Chen Zhang, Gang Wang Department of Dermatology, Xijing Hospital, Fourth Military Medical Univeristy, Xi'an, Shaanxi, China

11.00–11.10 009 (Poster 003) Aging alteration of skin T cells is different from that of blood T cells Hanako Koguchi-Yoshioka,1,2 Elena Hoffer,3 Stanley Cheuk,3 Yutaka Matsumura,2 Sa Vo,2 Yasuhiro Fujisawa,2 Manabu Fujimoto,1,2 Liv Eidsmo,3 Rachael A. Clark,4 Rei Watanabe2 1Dermatology, Osaka University, Suita, Osaka, Japan, 2Dermatology, University of Tsukuba, Tsukuba, Japan, 3Medicine Solna, Karolinska Institutet, Solna, Sweden, 4Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, United States

11.10–11.20 010 (Poster 277) DNMT3A is an epigenetic negative regulator of Wnt/ß-catenin pathway signalling in CYLD cutaneous syndrome Kirsty Hodgson,1 Helen Davies,2 Edward Schwalbe,1 Jonathan Coxhead,1 Naomi Sinclair,1 Xueqing Zou,2 Simon Cockell,1 Akhtar Husain,3 Serena Nik-Zainal,2 Neil Rajan1 1Newcastle University, Newcastle, United Kingdom, 2MRC Cancer Unit, Cambridge, United Kingdom, 3Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom

11.20–11.30 011 (Poster 453) Endovascular progenitors initiate and drive de novo vascularisation in melanoma James W. Dight, Jatin Patel, Ho Yi Wong, Ghazaleh Hashemi, Kiarash Khosrotehrani UQ Diamantina, Translational Research Institute, Brisbane, Queensland, Australia

11.30–11.40 Skin Science Foundation Michel Gilliet, Chris Griffiths

57

Friday Friday 20 September 201909.35–10.05 Room: Amphitheatre A

Celgene ESDR Guest Lecture

Arturo Zychlinsky (Berlin, Germany)

NETs in health and disease

Introduced by: Chris Griffiths

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FridayFriday 20 September 201911.55–12.55 Room: Poster Area

Poster Viewing (ODD Numbers)

Friday 20 September 201911.55–12.55 Room: Foyer

Poster walks 01–10

Walk 1 (Kiosk 01) Inflammation, Immunity and Infection 1: Skin Inflammation and immune cellsLEADER: Adelheid Elbe-Burger

012 021 059 082 350 371

Walk 2 (Kiosk 02) Inflammation, Immunity and Infection 2: Atopic dermatitisLEADER: Stefan Weidinger

370 380 384 385 418 427

Walk 3 (Kiosk 03) Inflammation, Immunity and Infection 3: Autoimmune Bullous, Drug reaction, GVHDLEADER: Rudiger Eming

071 112 114 159 332 358

Walk 4 (Kiosk 04) Clinical Research and Epidemiology 2: PsoriasisLEADER: Hervé Bachelez

118 120 126 150 154 399

Walk 5 (Kiosk 05) Epidermal Structure and Function 1LEADER: Sandrine Dubrac 207 226 262 273 310 410

Walk 6 (Kiosk 06) Wound Healing and Tissue RemodellingLEADER: Sabine Eming 630 632 633 634 636 637

Walk 7 (Kiosk 07) Photobiology and Pigmentation 1LEADER: Desmond Tobin 199 537 543 545 550 571

Walk 8 (Kiosk 08) Melanoma and other Skin Cancers 1: MelanomaLEADER: Christian Posch

440 456 474 476 479 482

Walk 9 (Kiosk 09) Melanoma and other Skin Cancers 2LEADER: Kiarash Khosrotehrani 438 446 462 477 517 519

Walk 10 (Kiosk 10) Genetics and Cell Based Therapy 1LEADER: Veronica Kinsler 092 275 276 286 315 318

Poster walks 01–10 and poster viewing session. All authors having ODD number posters, who are not participating in poster walks to stand by their posters. Deetails on page 77–82.

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Celgene Symposium – Targeting Extracellular Inflammatory Mediators or Intracellular Pathways for Dermatological Diseases: Which is Better?Chairperson: Prof. Errol Prens (Rotterdam, The Netherlands)

Overarching symposium objectives: For psoriasis, atopic dermatitis and hidradenitis suppurativa

1. Provide an overview of agents which target extracellular inflammatory mediators and intracellular pathways. 2. Critically evaluate extracellular and intracellular therapeutic approaches. 3. Identify areas of clinical research that are needed to advance our treatment and understanding

Program13.00–13.05 Opening statement

Errol Prens (Rotterdam, The Netherlands)

13.05–13.25 Focus on: Psoriasis Curdin Conrad (Lausanne, Switzerland)

13.25–13.30 Audience Q&A

13.30–13.50 Focus on: Atopic dermatitis Nick Reynolds (Newcastle upon Tyne, UK)


13.55–14.15 Focus on: Hidradenitis suppurativa Errol Prens (Rotterdam, The Netherlands)


14.20–14.30 Closing Statement Errol Prens (Rotterdam, The Netherlands)

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FridayFriday 20 September 201913.00–14.30 Room: Amphitheatre B

Janssen Symposium – Pathways to Silencing Psoriasis: Remission or Cure?

Learning objectives

After this session, participants should be able to:

• Recognize the clinical implications of the pathophysiology of psoriasis and its comorbidities • Devise strategies for treatment individualization and optimization based on the patient needs, genetic predisposition,

and pharmacoeconomic considerations • Critique the role of disease modification and hypothesize how treatment optimization strategies could be utilized for optimal

long-term patient outcomes


Jo Lambert (Ghent, Belgium)

13.05–13.25 The role of IL-23 in the pathogenesis of psoriasis – a common pathway in immune-mediated inflammatory diseases Jörg Prinz (Munich, Germany)

13.25–13.45 Optimizing psoriasis care of patients with comorbidity Jo Lambert (Ghent, Belgium)

13.45–14.05 Future of psoriasis: can lasting improvement be achieved in psoriasis care? Carle Paul (Toulouse, France)

14.05–14.25 Interactive Q&A session

14.25–14.30 Concluding remarks and close of the meeting Jörg Prinz (Munich, Germany)

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FridayFriday 20 September 201913.00–14.30 Room: Amphitheatre C

Chanel Symposium – Senescence & Skin AgingChair: Marie Videau (Paris, France)


Marie Videau, (Paris, France)

13.10–13.30 Senescence in aging research Karin Scharffetter-Kochanek (Ulm, Germany)

13.30–13.50 Cellular senescence and skin aging Johannes Grillari (Vienna, Austria)

13.50–14.05 Lipid mediators and skin senescence Florian Gruber (Vienna, Austria)

14.05–14.20 From senescence to anti-aging performance Sandra Forestier (Paris, France)

14.20–14.30 Closing remarks

Notes

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ESDR Guest Lecture

David E. Fisher (Boston, USA)

Melanoma’s unique pathogenesis: clues to therapeutic opportunities

Introduced by: Thomas Tuting

The ESDR Guest Lecture is given by internationally renowned scientists whose work has had significant impact on dermatology.

Past Speakers include Stefan W. Hell (2018), Matthias Mann (2017), Goncalo Abecasis (2016), Cedric Blanpain (2015), Luca Scorrano (2014), Richard Marais (2013), Martin Sprick (2013), Elaine Fuchs (2012), Manolis Pasparakis (2011), Kari Alitalo (2010), Ron Germain (2009), Robert Modlin (2008).

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FridayFriday 20 September 201915.20–16.20 Room: Poster Area

Poster Viewing (EVEN Numbers)

Friday 20 September 201915.20–16.20 Room: Foyer

Poster walks 11–20

Walk 11 (Kiosk 01) Inflammation, Immunity and Infection 4: Innate Immunity and InflammationLEADER: Christoph Schlapbach

405 407 413 420 424 428

Walk 12 (Kiosk 02) Inflammation, Immunity and Infection 5: Aopecia and vitiligoLEADER: Jérémy di Domizio

063 157 285 364 429 586

Walk 13 (Kiosk 03) Inflammation, Immunity and Infection 6: autoimmune bullous disordersLEADER: Enno Schmidt

002 010 011 018 036 044

Walk 14 (Kiosk 04) Acne-RosaceaLEADER: Emanuela Camera 001 193 224 321 354 589

Walk 15 (Kiosk 05) Epidermal Structure and Function 2LEADER: Sina Knapp 188 190 191 200 208 455

Walk 16 (Kiosk 06) Epidermal Structure and Function 3LEADER: Xiaolei Ding 210 256 262 269 272 593

Walk 17 (Kiosk 07) Stem cells and Tissue engineeringLEADER: John Connelly 467 585 591 595 603 604

Walk 18 (Kiosk 08) Melanoma and other Skin Cancers 3: MelanomaLEADER: Véronique Delmas

460 464 485 487 499 523

Walk 19 (Kiosk 09) Melanoma and other Skin Cancers 4: Lymphoma and Squamous Cell CarcinomaLEADER: Emmanuella Guenova

451 465 468 471 472 516

Walk 20 (Kiosk 10) Photobiology and Pigmentation 2LEADER: Rachel Watson 098 529 531 541 542 551

Poster walks 11–20 and poster viewing session. All authors having EVEN number posters, who are not participating in poster walks to stand by their posters. Details on page 83–88.

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René Touraine Guest Lecture

Marja Mikkola (Helsinki, Finland)

Hair follicle induction – old and new concepts

Introduced by: Thomas Luger

Friday 20 September 201917.20–17.35 Room: Amphitheatre A

ESDR Honorary Membership Awards

The ESDR is pleased to award 2019 Honorary Memberships to:

Birgit Lane (Singapore)

Introduced by Edel O’Toole

Erwin Tscachler (Vienna)

Introduced by Matthias Schmuth

Friday 20 September 201919.30–00.00 Location: Palais de la Bourse

Social Networking Event

The Place de la Bourse, originally called Place Royale, is one of the most successful examples of elegant French urban architecture. Located next to the Garonne river, the square and palace buildings were designed by royal architect Jacques Gabriel and completed in 1749.

Though modernised and refurbished in places, the Palais de la Bourse retains much of its original features and will be a spectacular event for this year's social networking event.

Delegates should take the tram to the central city (Public Transport tickets supplied).

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ESDR Annual General Meeting of MembersAll ESDR members are invited to join the 2019 AGM

AgendaOpening, Welcome David Kelsell

Approval of the Minutes of the AGM in Orlando 2018David Kelsell

Matters Arising from 2018 AGM David Kelsell

President’s Report David Kelsell

Secretary-Treasurer’s ReportChris Griffiths

New ESDR Members Chris Griffiths

ESDR President-Elect 2019/2020

Election of New Board Members David Kelsell

The ESDR Board proposes election of the following ESDR members to the Board for a period of 5 years: Christoph Schlapbach (Bern); Enikö Sonkoly (Stockholm); Rachel Watson (Manchester)

JID Editor’s Report Mark Udey

Other Business and Closing

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Notes

49TH

Saturday 21 September 2019

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21Saturday

Saturday 21 September 2019


09:00–10:30 Concurrent Sessions 5: Innate Immunity and Inflammation Amphitheatre A

09:00–10:30 Concurrent Session 6: Clinical Research and Epidemiology Amphitheatre B

09:00–10:30 Concurrent Session 7: Melanoma and Other Skin Cancers Amphitheatre C

09:00–10:30 Concurrent Session 8: Stem Cells, Skin Appendages and Tissue Regeneration E1 + E2

10:35–11:35 Poster Walks (21–30) and General Poster Viewing Foyer + Poster Area

11:45–12:15 EADV Guest Lecture: Tiago R. Matos Amphitheatre A

12:15–13:45 Clinical Saturday: Next-Generation Healthcare Amphitheatre A

13:45–14:00 ESDR Poster Prizes and Closing Ceremony Amphitheatre A

14:00–17:00 Skin Epigenetics Amphitheatre C

14:00–16:00 Novel Aspects in Vascular Biology of the Skin Amphitheatre B

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21SaturdaySaturday 21 September 2019

09.00–10.30 Room: Amphitheatre A

Concurrent Session 5 – Innate Immunity and InflammationChairs: Hervé Bachelez, Michel Gilliet


Program09.00–09.10 048 (Poster 400) Staphylococccus epidermidis can exacerbate atopic dermatitis through the secretion

of the cysteine protease EcpA L Cau,1,2 M Williams,1 T Nakatsuji,1 C Mainzer,3 B Closs,2 A Horswill4 and R Gallo1 1Dermatology, UCSD, La Jolla, CA, San Diego, CA, 2SILAB Softcare R&D, Brive, France, 3SILAB Inc, East Brunswick, NJ and 4Immunology & Microbiology, UC Denver, Denver, CO

09.10–09.20 049 (Poster 433) An innervated, vascularized and immunocompetent human skin model to evaluate the properties of chemical substances Q Muller,1,2 M Beaudet,2 S Bellenfant,2 R Pépin,2 A Brulefert,1 CG Mueller,1 F Berthod2 and V Flacher1

1Laboratoire d’Immunologie, Immunopathologie et Chimie Thérapeutique, CNRS I2CT / UPR3572, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France and 2Centre LOEX de l’Université Laval, Centre de recherche du CHU de Québec-UL, and Département de Chirurgie, Faculté de Médecine, Université Laval, Quebec, QC, Canada

09.20–09.30 050 (Poster 426) Type I interferon-driven pathogenic angiogenesis initiated by antimicrobial killing of B.oleronius during flare ups of rosacea A Mylonas,1 H Hawerkamp,2 Y Wang,3 S Meller,2 B Homey,2 L Mazzolai,1 J Di Domizio,1 M Gilliet,1 A Hovnanian3 and C Conrad1 1University Hospital of Lausanne, Lausanne, Switzerland, 2University Hospital of Dusseldorf, Dusseldorf, Germany and 3INSERM Institute Imagine, Paris, France

09.30–09.40 051 (Poster 389) Spectrum of actions of PPARγ modulation in acne sebum E Camera,2 M Ottaviani,2 E Flori,2 A Mastrofrancesco,2 S Briganti,2 F Marini,1 V Lora2 and M Picardo2 1Department of Chemistry, ‘La Sapienza’ University, Rome, Italy and 2Laboratory of Cutaneous Physiopathology, San Gallicano Dermatological Institute IRCCS, Rome, Italy

09.40–09.50 052 (Poster 348) Homeostatic functions of dermokine in skin barrier and innate immunity A Utsunomiya,1 T Chino,1 N Utsunomiya,1 VH Luong,1 M Sugai,2 K Higashi,3 K Sugawara,4 D Tsuruta,4 N Oyama1 and M Hasegawa1 1Dermatology, Fukui University, Eiheiji, Japan, 2Molecular Genetics, Fukui University, Fukui, Japan, 3Sumitomo Chemical, Osaka, Japan and 4Dermatology, Osaka City University, Fukui, Japan

09.50–10.00 053 (Poster 372) Inhibition of phosphatidylinositol-3-kinase δ improves tissue destruction in pemphigoid diseases by impairing neutrophil function S Ghorbanalipoor,1 S Emtenani,1 K Izumi,2 O Ibrahim,1 J Hobusch,1 K Bieber,1 M Parker,3 P Smith,3 E Schmidt1,4 and R Ludwig1 1Lubeck Institute of Experimental Dermatology, Lubeck, Germany, 2Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 3Incyte Corporation, Wilmington, DE and 4Department of Dermatology, University of Lubeck, Lubeck, Germany

10.00–10.10 054 (Poster 339) Prevention of airway and intestinal inflammation in a humanized mouse model of allergy by depletion of natural killer cells prior to PBMC engraftment R Ose,1 B Weigmann,2 J Maxeiner,3 P Schuster,3 J Saloga1 and I Bellinghausen1 1Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany, 2Department of Internal Medicine I, University Hospital Erlangen, University Erlangen-Nurnberg, Erlangen, Germany and 3Asthma Core Facility, Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University, Mainz, Germany

10.10–10.20 055 (Poster 331) Lymphatic flow blockade amplifies inflammation in imiquimod-induced psoriasis-like skin lesions H Boki,1,2 T Kimura,1,2 T Miyagaki,1,2 H Suga,1 M Sugaya,3 A Blauvelt,4 H Okochi2 and S Sato1 1Dermatology, the University of Tokyo Graduate School of Medicine, Bunkyo-ku, Japan, 2Regenerative Medicine, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan, 3Dermatology, International University of Health and Welfare, Tokyo, Japan and 4Oregon Medical Research Center, Portland, OR

10.20–10.30 056 (Poster 435) Human group 2 innate lymphoid cells differentiate into interleukin-17A producing cells in psoriasis MB Teunissen,1 JH Bernink,2 Y Ohne,3 L Krabbendam,2 MA de Rie,1 H Spits,2 XR Ros2 and AA Humbles3 1Dermatology, Amsterdam UMC, location AMC, Amsterdam, Netherlands, 2Experimental Immunology, Amsterdam UMC, location AMC, Amsterdam, Netherlands and 3Respiratory, Inflammation and Autoimmune (RIA), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD

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SaturdaySaturday 21 Septmber 201909.00–10.30 Room: Amphitheatre B

Concurrent Session 6 – Clinical Research and EpidemiologyChairs: Alain Taïeb, Kaisa Tasanen-Määttä


Program09.00–09.10 057 (Poster 093) Early major adverse cardiovascular events following the initiation of the anti-interleukin

12/23 antibody ustekinumab. A population-based case-time-control study F Poizeau,1 E Nowak,1 S Kerbrat,1 C Droitcourt,1 E Sbidian,2 B Guillot,5 H Bachelez,3 H Ait- Oufella,4 E Oger1 and A Dupuy1 1EA 7449 REPERES (Pharmacoepidemiology and Health Services Research), Rennes, France, 2EA EpiDermE 7379, Paris Est University, Créteil, France, 3Inserm UMR1163, Institut Imagine, Paris, France, 4Inserm U970, Sorbonne University, Paris, France and 5CHU, Montpellier, France

09.10–09.20 058 (Poster 094) Integration of multi-omic data identifies psoriasis endotypes correlating with clinical and immunological phenotypes M Cameron,1 J Golden,1 B Richardson,1 G Damiani,2 M Ali,3 A Young,2 C Nichols,1 N Ward,3 T McCormick2 and K Cooper2 1Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 2Department of Dermatology, University Hospitals, Cleveland, OH and 3Department of Nutrition, Case Western Reserve University, Cleveland, OH

09.20–09.30 059 (Poster 110) Host-microbial dialogues in atopic dermatitis and psoriasis N Fyhrquist1, E Consortium2 1Karolinska Institute, Stockholm, Sweden2, EU-MAARS Consortium, Helsinki, Finland

09.30–09.40 060 (Poster 097) Novel Genomic Signature Predicts Response to Ruxolitinib Cream in Psoriasis H Liu and MD Howell Translational Sciences, Incyte Research Institute, Wilmington, DE

09.40–09.50 061 (Poster 087) Revisiting pachyonychia congenita: a case cohort study in 815 patients L Samuelov,1 F Smith,2 D Hansen3 and E Sprecher1 1Dermatology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Pachyonychia Congenita Project, Holladay, UT and 3University of Utah, Salt Lake City, UT

09.50–10.00 062 (Poster 278) Generation and clinical application of gene modified autologous epidermal sheets in Netherton syndrome – lessons learned from a phase 1 trial W Di,1 SM Lwin,2 A Petrova,1 C Bernadis,3 F Syed,1 AE Martinez,4 JA McGrath,2 AJ Thrasher,1 JE Mellerio2 and W Qasim1 1UCL GOS Institute of Child Health, London, United Kingdom, 2St John’s Institute of Dermatology, King’s College London, London, United Kingdom, 3Plastic Surgery Unit, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom and 4Dermatology Department, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom

10.00–10.10 063 (Poster 245) Successful treatment of Netherton syndrome with dupilumab S Blunder, M Schmuth and R Gruber Innsbruck Medical University, Innsbruck, Austria

10.10–10.20 064 (Poster 088) A phase I/II study on the anti-CD3/CD7 immunotoxin combination for the treatment of steroid-refractory acute GVHD T Matos,1 FW Preijers,4 LF van Groningen,4 C Groth,3 S Blok,1 C Reicherts,3 J Levine,2 E Hooren,2 N Blijlevens,4 Y Oosterhout,2 W Velden4 and M Stelljes3 1AMC, Amsterdam, Netherlands, 2Xenicos, Nijmegen, Netherlands, 3Muenster University, Muenster, Germany and 4RadboudUMC, Nijmegen, Netherlands

10.20–10.30 065 (Poster 091) IPH4102 (an anti-KIR3DL2 antibody) in refractory cutaneous T cell lymphoma M Bagot,1,2 P Porcu,3 A Marie-Cardine,2 M Battistella,4 A Bensussan,2 C Paturel,5 C Bonnafous,5 H Sicard,5 H Azim5 and Y Kim6 1Dermatology, Hopital Saint Louis, Paris, France, 2INSERMU976, Paris, France, 3Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, PA, 4Pathology, Hopital Saint Louis, Paris, France, 5Innate Pharma, Marseille, France and 6Dermatology, Stanford Cancer Institute, Stanford, CA

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SaturdaySaturday 21 September 201909.00–10.30 Room: Amphitheatre C

Concurrent Session 7 – Melanoma and Other Skin Cancers Chairs: Thomas Tüting, Amaya Viros


Program09.00–09.10 066 (Poster 436) Macrophages promote growth of squamous cancer independent of T cells

X Wang Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

09.10–09.20 067 (Poster 463) Hypoxia-inducible factor-1α play a critical role in UVB-induced tumorigenesis by affecting DNA repair capacity and oxidative stress W Mahfouf, E Muzotte, L Dousset, F Moisan, A Taieb and HR Rezvani Univ Bordeaux, Inserm, BMGIC, UMR 1035, Bordeaux, France

09.20–09.30 068 (Poster 520) Epidermal clonal expansion upon UV irradiation: consequences of the epidermal duality of proliferative behaviour on the skin carcinogenesis E Roy, H Wong and K Khosrotehrani Diamantina Institute, University of Queensland, Brisbane, QLD, Australia

09.30–09.40 069 (Poster 450) Sun exposed individual normal keratinocytes tolerate multiple cancer-causing mutations in vivo A South,1 M Savarese,1 I Fuentes,1 M Prisco,1 N den Breens,1 G Kumar,1 A Luginbuhl,1 R Cho2 and J Curry1 1Thomas Jefferson University, Philadelphia, PA and 2University of California San Francisco, San Francisco, CA

09.40–09.50 070 (Poster 437) Neurotrophin receptors exert opposing effects in the development and invasiveness of cutaneous squamous cell carcinoma E Palazzo,1 M Quadri,1 N Tiso,2 G Gutierrez-Cruz,3 R Lotti,1 A Marconi,1 M Morasso4 and C Pincelli1 1University of Modena, Modena, Italy, 2University of Padua, Padua, Italy, 3Office of Science and Technology, NIAMS/NIH, Bethesda, MD and 4Laboratory of Skin Biology, NIAMS/NIH, Bethesda, MD

09.50–10.00 071 (Poster 475) Targeting the JAK/STAT3 pathway with ruxolitinib for RDEB-cSCC therapy J Jackow, R Hayashi, D Owens, R Perez-Lorenzo, C Hansen, D DeLorenzo, Z Guo and A Christiano Dermatology, Columbia University, New York, NY, USA

10.00–10.10 072 (Poster 447) Complement component C1r upregulates the expression of matrix metalloproteinase-1, -13 and -10 and promotes invasion of cutaneous squamous carcinoma cells K Viiklepp,1 L Nissinen,1 M Ojalill,2 P Riihilä,1 S Meri,3 J Heino2 and V Kähäri1 1Department of Dermatology, University of Turku and Turku University Hospital, Turku, Finland, Turku, Finland, 2Department of Biochemistry, University of Turku, Turku, Finland and 3Haartman Institute, University of Helsinki, Helsinki, Finland

10.10–10.20 073 (Poster 442) CLEC12B a new gene implicated in melanoma H Montaudié,1 L Sormani Le Bourhis,1 B Dadone-Montaudié,2 G Beranger,1 Y Cheli,1 V Petit,3 S Rocchi,1 F Gesbert,3 L Larue3 and T Passeron1 1NSERM, U1065, C3M, Nice, France, 2Department of Pathology, Nice University Hospital, Nice, France and 3INSERM U1021, Institut Curie, PSL Research University, Orsay, France

10.20–10.30 074 (Poster 503) p53-regulated long non-coding RNA PRECSIT promotes progression of cutaneous squamous cell carcinoma via STAT3 signaling M Piipponen,1 L Nissinen,1 P Riihilä,1 M Farshchian,1 M Kallajoki,2 J Peltonen,3 S Peltonen1 and V Kähäri1 1Department of Dermatology, University of Turku, Turku, Finland, 2Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland and 3Department of Cell Biology and Anatomy, University of Turku, Turku, Finland

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SaturdaySaturday 21 September 201909.00–10.30 Room: E1+E2

Concurrent Session 8 – Stem Cells Skin Appendages and Tissue RegenerationChairs: Sabine Eming, Ryan O'Shaughnessy


Program09.00–09.10 075 (Poster 577) The atypical kinase C regulates epidermal adhesive junctions and the cytoskeleton

essential for epidermal stratification M Rubsam,1,2 F Tellkamp,1,2 H Nolte,2,3,5 M Rinschen,2,4 M Peskoller,1,2,3 M Kruger1,2,5 and CM Niessen1,2,3 1Department of Dermatology, University of Cologne, Cologne, Germany, 2CECAD, University of Cologne, Cologne, Germany, 3CMMC, University of Cologne, Cologne, Germany, 4Department of Internal Medicine II, University of Cologne, Cologne, Germany and 5Institute for Genetics, University of Cologne, Cologne, Germany

09.10–09.20 076 (Poster 588) Skin fibroblast heterogeneity and plasticity are determined by the local niche A Korosec, S Frech, A Forsthuber, K Lipp and BM Lichtenberger Skin & Endothelium Research Division (SERD), Department of Dermatology, Medical University of Vienna, Vienna, Austria

09.20–09.30 077 (Poster 574) Murine sebaceous gland homeostasis requires intact cutaneous innervation in a hair cycledependent context R Clayton,1,2 E Hinde,1 X Lim,2 R Paus1 and M van Steensel2 1Centre for Dermatology, University of Manchester, Manchester, United Kingdom and 2Skin Research Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore

09.30–09.40 078 (Poster 579) Single cell transcriptome and epigenome analyses in a murine model of dystrophic epidermolysis bullosa T Shimbo,1 S Yamazaki,1,2 T Kitayama,1,2 Y Ouchi,1,2 R Yamamoto,1,2 E Takaki,1,2 L Bruckner- Tuderman,3 J Uitto,4 Y Kaneda1 and K Tamai1 1Osaka university, Suita, Japan, 2StemRIM, Ibaraki, Japan, 3Freiburg Institute for Advanced Studies School of Life Sciences, Freiburg, Germany and 4Jefferson University, Philadelphia, PA

09.40–09.50 079 (Poster 575) Characterization of aged dermal stem cell phenotype: implications for skin homeostasis L Yndriago,1 H Iribar,1 I Prieto,1 V Pérez,1 L Gardeazabal,1 A Maeva,2 A Strange,2 A Gutierrez,1 A Matheu1 and A Izeta1 1Biodonostia Health Research Institute, San Sebastián, Spain and 2UCL Eastman Dental Institute, London, United Kingdom

09.50–10.00 080 (Poster 570) DNA dioxygenases Tet1/2/3 control cell differentiation in the hair follicle keratinocytes via modulating the activity of BMP signaling pathway G Chen,1 Q Xu,3 M Fessing,2 A Mardaryev,2 A Sharov,1 G Xu3 and V Botchkarev1,2 1Dermatology, Boston University, Boston, MA, 2Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom and 3Shanghai Institute Biological Sciences, Shanghai, China

10.00–10.10 081 (Poster 580) Spontaneous replication stress in Hair Follicle Stem Cells leads to inflammation in Hidradenitis Suppurativa C Orvain,1,2 Y Lin,3F Jean-Louis,1,2 B Hersant,4,5 N Ortonne,6 C Hotz,4,5 P Wolkenstein,4,5 P Pasero,3 Y Lévy1,2 and S Hue1,2 1Inserm U955-Equipe 16, Créteil, France, 2Vaccine Research Institute (VRI), Créteil, France, 3Institut de Génétique Humaine-CNRS, Montpellier, France, 4Plastic, Reconstructive and Aesthetic Surgery Department, Henri Mondor Hospital, Créteil, France, 5Dermatology Department, Henri Mondor Hospital, Créteil, France and 6Pathology Department, Henri Mondor Hospital, Créteil, France

10.10–10.20 082 (Poster 587) The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer A Geueke,1,2 F Kuster,1,2 G Mantellato1,2 and C Niemann1,2 1Center for Molecular Medicine, University of Cologne, Cologne, Germany and 2Institute of Biochemistry II, University of Cologne, Cologne, Germany

10.20–10.30 083 (Poster 582) Differentiation of human skin-derived precursors (SKPs) into functional sensory neurons A Bataille,1,2 R Leschiera,1 N Le Goux,3 O Mignen,3 C Brun,4 T Oddos,4 L Misery1,2 and N Lebonvallet1 1Laboratory of Interactions Neurons Keratinocytes (EA4685), Brest, France, 2Department of Dermatology, University Hospital, BREST, France, 3University of Western Brittany, Inserm U1227, BREST, France and 4Johnson & Johnson Santé Beauté France, Val de Reuil, France

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SaturdaySaturday 21 September 201910.35–11.35 Room: Poster Area

General poster session (all authors to be by their posters)

Saturday 21 September 201910.35–11.35 Room: Foyer + Poster Area

Poster walks 21–30 and General Poster Viewing

Walk 21 (Kiosk 01) Inflammation, Immunity and Infection 7: Innate immunity and skin InflammationLEADER: Katia Boniface

030 035 046 334 343 344

Walk 22 (Kiosk 02) Inflammation, Immunity and Infection 8: PsoriasisLEADER: Curdin Conrad

004 025 027 066 391 425

Walk 23 (Kiosk 03) Inflammation, Immunity and Infection 9: Bacteria, viruses and fungalLEADER: Julien Seneschal

057 076 130 382 383 626

Walk 24 (Kiosk 04) Inflammation, Immunity and Infection 10: Systemic Sclerosis, Dermatomyositis, LupusLEADER: Jean-David Bouaziz

015 034 042 043 045 540

Walk 25 (Kiosk 05) Clinical Research and Epidemiology 1: Atopic Dermatitis, Allergy, ItchLEADER: Alain Taïeb

089 101 102 106 127 145

Walk 26 (Kiosk 06) Epidermal Structure and Function 4LEADER: Yves Poumay 197 237 247 262 455 583

Walk 27 (Kiosk 07) Genetics and Cell Based Therapy 2: Epidermolysis bullosaLEADER: Cristina Has

287 295 307 312 584 631

Walk 28 (Kiosk 08) Hair follicle and skin appendagesLEADER: Ralf Paus 594 597 599 601 607 613

Walk 29 (Kiosk 09) Melanoma and other Skin Cancers 5: Melanoma, Non melanoma skin cancersLEADER: Hamid Rezvani

115 119 125 129 443 458

Walk 30 (Kiosk 10) Melanoma and other Skin Cancers 6LEADER: Cornelia Mauch 023 386 397 423 452 457

Poster walks and general poster viewing session. All authors not participating in poster walks to stand by their posters. Details on page 88–94.

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SaturdaySaturday 21 September 201911.45–12.15 Room: Amphitheatre A

EADV Guest Lecture

Tiago R. Matos (Amsterdam, The Netherlands)

Skin Resident T Cells: implications for immune homeostasis and disease

Introduced by: Erwin Tschachler

Saturday 21 September 201912.15–13.45 Room: Amphitheatre A

Cllinical Saturday: Next Generation HealthcareChairs: Edel O’Toole, Menno de Rie

Program12.15–12.35 Artificial Intelligence

in Dermatology: Enhancing the Expert Andre Esteva (Stanford, USA)

12.35–12.55 Personalised Targeted Therapies in Mosaic Disorders Veronica Kinsler (London, UK)

12.55–13.15 Atopic Dermatitis: The Long and Challenging Path to Precision Medicine Thomas Bieber (Bonn, Germany)

13.15–13.45 The 100,000 Genomes Project: Impact of Genomic Medicine in the Clinic Ellen Thomas (Tonbridge, UK)

Clinical Saturday 2019 is run in association with the European Academy for Dermatology and Venereology (EADV). This year’s focus is on next-generation healthcare.

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SaturdaySaturday 21 September 201913.45–14.00 Room: Amphitheatre A

ESDR Poster Prizes and Closing Ceremony

2019 Poster Prizes are supported by:

Saturday 21 September 201914.00–17.00 Room: Amphitheatre C

Skin EpigeneticsOrganisers: Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Boston)

Program14.00–14.05 Introductory remarks

Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Boston)

14.05–14.40 Opening Keynote Lecture HDAC functions in skin homeostasis and disease Sarah Millar (New York)

14.40–15.00 DNA hydroxymethylation and TET enzymes in the control of skin development and regeneration Mike Fessing (Bradford)

15.00–15.20 DNA hydroxymethylation and TET enzymes in the control of hair growth Andrei Mardaryev (Bradford)

15.20–15.40 Transcription factor p63, a master regulator of the enhancer landscape during epidermal differentiation Jo Zhou (Nijmegen)

15.40–16.00 Mechanisms of long non-coding RNA-mediated control of epidermal homeostasis Markus Kretz (Regensburg)

16.00–16.20 Biomechanical regulation of nuclear architecture in keratinocytes John Connelly (London)

16.20–16.55 Closing Keynote Lecture Defective chromatin-mediated transcriptional silencing and aberrant enhancer activity in multiple sclerosis Christian Muchardt (Paris)

16.55–17.00 Closing remarks Salvador Aznar Benitah (Barcelona) and Vladimir Botchkarev (Boston)

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SaturdaySaturday 21 September 201914.00–16.00 Room: Amphitheatre B

Novel Aspects in Vascular Biology of the Skin The organisers acknowledge the support of Pierre Fabre Dermatologie for this event.

Chairs: Christine Léauté-Labrèze (Bordeaux) , Alain Taïeb (Bordeaux)

Program14.00–14.30 Studying physiological and pathological angiogenesis in vivo: lessons from alternative preclinical animal

models Martin Hagedorn (Bordeaux)

14.30–15.00 Telocytes in infantile hemangioma: target cells for propranolol? François Moisan (Bordeaux)

15.00–15.30 Repurposing anti-hypertensive drugs in the treatment of malignant cutaneous and extracutaneous vascular tumours Eddy Pasquier (Marseille)

15.30–16.00 Pathophysiology of the vascular system anomalies in rosacea Martin Steinhoff (Doha)

Notes

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Saturday2019 Poster Walks are supported by:

Poster Walk 01 (Kiosk 01)Inflammation, Immunity and Infection 1: Skin Inflammation and immune cells

Leader: Adelheid Elbe-Bürger

012Profiling immune cells using tissue cytometry and immune cell clustersKim Blenman

021New gold compound shows immunesuppressive functions and leads to an amelioration of skin inflammationStefanie Haeberle

059Functional diversity among dermal dendritic cell subsets for CD8+ T cell activation in the skinTetsuya Honda

082CD8+ IL-23R+ PD-1+ T cells in psoriatic skin possibly play a role in maintaining inflammation and disease recurrencePawit Phadungsaksawasdi

350Dual role of CARD14 in skin inflammatory diseasesAlon Peled

371The expression of p19 and EBI3 in epidermal keratinocytes under the stimulation with inflammatory cytokinesKota Tachibana

Poster Walk 02 (Kiosk 02)Inflammation, Immunity and Infection 2: Atopic dermatitis

Leader: Stefan Weidinger

370Cytokines and filaggrin expression alter AD skin-derived Staphylococcus aureus uptake into keratinocytesRyu Miyake

Poster Walks

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380Innate lymphoid cells (ILCs) in healthy and atopic bloodNatalia Alkon

384Mitochondria: novel therapeutic targets in atopic dermatitis?Sandrine Dubrac

385Ruxolitinib cream ameliorates a preclinical model of skin dermatitis via modulation of inflammatory T-cell subsetsMelissa Parker

418Early identification of atopic dermatitis patients in need of systemic immunosuppressive treatmentDaphne Bakker

427Predicting treatment response to methotrexate in atopic dermatitis patients using clinical characteristics and serum biomarkersJudith Thijs

Poster Walk 03 (Kiosk 03)Inflammation, Immunity and Infection 3: Autoimmune Bullous, Drug reaction, GVHD

Leader: Rüdiger Eming

071The autoimmune IgG subclass response defines the IgG deposition pattern in pemphigus patient skinHendri Pas

112Substantially increased risk of dermatitis herpetiformis in children and adolescents with atopic dermatitisLaura Huilaja

114Use of etanercept in toxic epidermal necrolysis: a single center experience in a cohort of 30 patientsDario Didona

159Plasma Elafin as a biomarker for Skin Graft Versus Host DiseaseLeni George

332Plasma exosomal miR-375-3p regulates ferroptosis in keratinocytes by targeting GPX4 in SJS/TENChen Zhang

358Human-based T cell-skin models for graft-versus-host diseaseFlorian Groeber-Becker

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Poster Walk 04 (Kiosk 04)Clinical Research and Epidemiology 2: Psoriasis

Leader: Hervé Bachelez

118Altered intestinal barrier in psoriasis is associated with disease severity, gastrointestinal symptoms and presence of bacteria metabolites in the bloodMariusz Sikora

120Functional and structural brain connectivity in psoriasis patients and healthy controls: A brain imaging study after exposure to mentally-induced itchPeyman Najafi

126Ixekizumab for psoriasis: characteristics of patients recruited to the British Association of Dermatologists Biologics and Immunomodulator Register in the first year post launchJulie Mount

150Sex and smoke-related differences in the severity of Palmoplantar PustulosisNatashia Benzian-Olsson

154MDR1-expressing T cells accumulate in the resolved skin of psoriatic plaque after treatment with topical corticosteroid but not with anti-IL-17A mAbToshiharu Fujiyama

399Distinct gene expression signatures differentiate clinical response to ustekinumab compared to adalimumab in psoriasisAshley Rider

Poster Walk 05 (Kiosk 05)Epidermal Structure and Function: Signaling

Leader: Sandrine Dubrac

207IL-17E (IL-25) alters epidermal homeostasis in a matter distinct from IL-17AJulia Borowczyk-Michalowska

226Impaired CCL2 expression caused by the OSMR gene mutations in familial primary localized cutaneous amyloidosis

236The involvement of neurons/keratinocytes interactions in the expression of the junction proteins involved in the skin barrier functionIanis Cousin

247A role for iRhom2 in pachyonychia congenitaMatthew Brooke

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310PI3-Kinase inhibitors represent a novel class of drug repurposing candidates to prevent glucocorticoid-induced skin atrophyIrina Budunova

410Cartilage oligomeric matrix protein (COMP) negatively influences keratinocyte proliferation via α5β1-integrin: Potential relevance of altered COMP expression in psoriasisRenáta Bozó

Poster Walk 06 (Kiosk 06)Wound Healing and Tissue Remodelling

Leader: Sabine Eming

630iRHOM2 is a key regulator of the cytoskeletal stress responseLisa McGinty

632Regulation of transforming growth factor beta bioavailability by phosphorylationMugdha Sawant

633Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migrationDongqing Li

634Diabetes-associated high glucose levels negatively affects cultured human fibroblast subpopulations isolated from haired skinStephen Sikkink

636Mechano-sensing and inflammatory signalling in normal and keloid dermal fibroblasts

637Hypoxia-induced Epithelial-to-Mesenchymal transition mediates fibroblast abnormalities via EKR activation in cutaneous wound healingJihee Kim

Poster Walk 07 (Kiosk 07)Pigmentation of the skin

Leader: Desmond Tobin

199ENPP1: connecting calcification, keratinization and pigmentationMor Pavlovsky

529Polyamines: novel regulators of human epidermal pigmentationLeah Vardy

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531Epigenetic mechanism linked to pigmented spots explored by in silico, in vitro and in vivo methodsSabine Pain

537Obesity is a risk factor for pigmented spots through the blood inflammatory factorShu Nishikori

545Keratinocyte-derived glycoprotein non-metastatic melanoma protein B protects melanocytes from oxidative stress in a CD44-independent mannerQianqian Wang

571Identifying a novel mechanism of human skin pigmentationElisabeth Roider

Poster Walk 08 (Kiosk 08)Melanoma and other Skin Cancers 1: Melanoma

Leader: Christian Posch

440BRN2 is a non-canonical melanoma tumor-suppressorLionel Larue

456Bortezomib induces immunogenic cell death in melanoma and enhances immune responses in vivoSheena Daignault

474Inherited duplications of PPP2R3B promote naevi and melanoma via a novel C21orf91-driven proliferative phenotypeSatyamaanasa Polubothu

476GJB5 association with BRAF mutation and survival in cutaneous melanomaDaniele Bergamaschi

479B cells sustain inflammation and predict response to immune checkpoint blockade in human melanomaStephan Wagner

482Biomolecular profile and reflectance confocal microscopy refine diagnosis and predict response to therapy in melanoma subsetsAlessandra Marconi

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Poster Walk 09 (Kiosk 09)Melanoma and other Skin Cancers: Tumorigenesis

Leader: Kiarash Khosrotehrani

438Development and validation of an 80-gene UV biomarker panel for stratification of skin cancer riskDawn Queen

446Tumorigenesis mediated by extracellular vesicles through a Dsg2/miR-146a/IL-8 signaling axisMy Mahoney

462DHODH inhibition for chemoprevention and combination therapy of UVB-induced epithelial oncogenesisLea Dousset

477Generating Merkel cell polyomavirus reactive T cells from healthy donors for adoptive immunotherapyIsaac Brownell

517Laser dermabrasion: a potential treatment for non-melanoma skin cancersHo Yi Wong

519Paranuclear cytokeratin aggregates help Merkel cell carcinoma evade extrinsic apoptosisNatasha Hill

Poster Walk 10 (Kiosk 10)Genetics and Cell Based Therapy 1

Leader: Veronica Kinsler

092Novel biallelic RIPK4 mutations cause ectodermal dysplasia with cutaneous syndactylyPaola Fortugno

275Permanent alteration of Abcc6 with in vivo CRISPR-Cas9 genome editingDalong Zhi

276Exome sequencing identifies semi-dominant GPNMB mutations in amyloidosis cutis dyschromicaAlexandros Onoufriadis

286Expanding the clinical spectrum of erythrokeratolysis hiemalisJanan Mohamad

315Cerebriform sebaceous nevus is caused by the specific postzygotic FGRF2 p.(Cys382Arg) variationPaul Kuentz

318A novel pathomechanism: are Cockayne syndrome and trichothiodystrophy ribosomopathies?Sebastian Iben

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Poster Walk 11 (Kiosk 01)Inflammation, Immunity and Infection 4: Innate Immunity and Inflammation

Leader: Christoph Schlapbach

405Lyso-Pospholipids contribute to the inflammatory nature of senescent dermal fibroblastsVera Pils

407Novel transcriptomic network interactions in the human skin treated with topical glucocorticoidIrina Budunova

413The chromatin architectural protein CTCF regulates expression of pro-inflammatory cytokines in the skin cellsAndrei Mardaryev

420A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death in keratinocytesDiana Panayotova-Dimitrova

424Next generation sequencing of myeloid neoplasm-associated Sweet syndrome shows similar mutational profile of skin and myeloid disorderClemence Lepelletier

428Comparative mass spectrometry proteomics of epidermal samples obtained by non-invasive tape stripping from inflammatory skin diseasesAnna Berekméri

Poster Walk 12 (Kiosk 02)Inflammation, Immunity and Infection 5: Alopecia and vitiligo

Leader: Jérémy di Domizio

063Role of the NKG2D/NKG2DL axis in the progression of vitiligoClément Jacquemin

157Ruxolitinib Cream significantly modulates inflammatory profiles of patients with vitiligoSherry Owens

285MHC risk haplotype sequencing and allele-specific genome editing by CRISPR/Cas9 system reveal cchcr1 as susceptibility gene for alopecia areataShigaku Ikeda

364Adenosine triphosphate-P2X7 axis mediates melanocyte death and skin trafficking of CD8+ T cells by CXCL9 through inflammasome activation in vitiligoShinwon Hwang

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429Type 2 Immunity Influences Hair Follicle Stem Cell Proliferation and Skin HomeostasisRoberto Ricardo

586New concept of cytokine balance in alopecia areata with atopic dermatitisReiko Kageyama

Poster Walk 13 (Kiosk 03)Inflammation, Immunity and Infection 6: autoimmune bullous disorders

Leader: Enno Schmidt

002The impact of Fc-binding proteins on IgG targeting BP180Hiroaki Iwata

010Development of a Desmocollin-3 active mouse model recapitulating human atypical PemphigusRoberta Lotti

011Preclinical mechanism of action of PRN1008, a reversible covalent bruton’s tyrosine kinase inhibitor in clinical development for PemphigusClaire Langrish

018Evolution of autoreactive B and T cells in pemphigus patients with Rituximab or corticosteroid regimen treatmentMaud Maho-Vaillant

036Targeted inhibition of complement at the basement-membrane zone in pemphigoid diseasesChristoph Hammers

044A unique mechanism of epithelial detachment in mucous membrane pemphigoid caused by autoantibodies against the C-terminus of COL17Mayumi Kamaguchi

Poster Walk 14 (Kiosk 04)Acne-Rosacea

Leader: Emanuela Camera

001Genome-wide association study of acne inversa in a multi-ethnic cohortLynn Petukhova

193An in vitro model of acne hyperseborrhea and inflammation based on hiPSC derived sebocytes

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224Revealing barrier alterations in rosacea skin at the molecular levelZsolt Dajnoki

321The role of abnormal cutaneous steroidogenesis in the pathogenesis of rosaceaSoyun Cho

354Development and characterization of a new in vitro 3d model that embraced Acneic skin hallmarks

589Loss of GATA6 contributes to acne pathogenesis in human skinBenedicte Oules

Poster Walk 15 (Kiosk 05)Epidermal Structure and Function: Cell biology

Leader: Sina Knapp

188NAT19 is novel biomarker for sensing glucose in healthy and type I diabetic skinNsrein ALI

190Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry SkinAkio Tanaka

191Aryl hydrocarbon receptor controls epidermal differentiation and host defense response by regulation of AP1/AP2 transcription factor expressionEllen van den Bogaard

200Transgenic kallikrein 14 mice display major hair defects associated with desmoglein 3 and 4 degradation and an inflammatory signature

208The Aryl hydrocarbon receptor (AhR) induces the expression of aldo-keto reductase (AKR) 1C3 in keratinocytes in a ligand-specific mannerChristian Vogeley

455The Function of RIPK4 in Keratinocyte Proliferation and TumorigenesisBrian Poligone

Poster Walk 16 (Kiosk 06)Epidermal Structure and Function: Systems biology

Leader: Xiaolei Ding

210Three-dimensional models of human skin at single-cell resolution in health and diseaseClarisse Ganier

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256Comparative transcriptomics of organotypic skin models defines components of the core molecular machinery of epidermal cornificationJulia Lachner

262A spatially resolved proteomic atlas of human skin and its associated immune system

269Agent-based computational modeling of the human epidermis and applications

272Understanding cell heterogeneity in the basal layer of human epidermisGeorgios Stamatas

593Label-free identification of human keratinocyte stem cells by deep learning-based quantitative cell motion analysisDaisuke Nanba

Poster Walk 17 (Kiosk 07)Stem cells and Tissue engineering

Leader: John Connelly

467Immunotherapy with 4-1BBL-expressing iPScell-derived myeloid linesHaruka Kuriyama

585Identifying cancer stem cells in patient specimens through high-content imaging – biological insights and prognostic potentialGehad Youssef

591A new 3d skin model containing autologous immune cells reconstructed by tissue engineeringCarine Mainzer

595New autologous engineered pigmented skin for human skin graftMuriel Cario

603Pathological modeling of epidermolysis bullosa simplex (EBS) using induced pluripotent stem cells (iPSC)Manon Bonnette

604Towards the development of a completely humanized model for the investigation of sensory nervous system in scalp skin ex vivoJeremy Cheret

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Poster Walk 18 (Kiosk 08)Melanoma and other Skin Cancers 3: Melanoma

Leader: Lionel Larue

460Investigation of senescence-escape reveals new melanoma vulnerabilitiesKatrin Platzer

464Serum level of tumor-associated macrophage (TAMs)-related factors may be a predictive marker of the effectiveness of nivolumab in patients with advanced cutaneous melanomaTaku Fujimura

485Vaspin (serpin A12) increases melanoma cell invasion through extracellular matrix modelsChris Morris

487C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of MEK and AKT inhibitors in vitro and in vivoJeremy Raymond

499miR-204-5p modulators application in vitro and in vivo in melanoma cellsTatiana Ruksha

523MITF-mediated extracellular matrix changes control intratumour heterogeneity in melanomaNikolas Haass

Poster Walk 19 (Kiosk 09)Melanoma and other Skin Cancers 4:Lymphoma and Squamous Cell Carcinoma

Leader: Emmanuella Guenova

451Meiomitosis, a novel mechanism of carcinogenesis in head and neck squamous cell carcinomasJennifer Gantchev

465Cutaneous T-cell lymphoma cells release proapoptotic Fas ligand in lysosomal secretory vesiclesAdèle De Masson

465Cutaneous T-cell lymphoma cells release proapoptotic Fas ligand in lysosomal secretory vesiclesAdele de Masson

468Cutaneous squamous cell carcinomas are infiltrated with CD8+CD103+ resident memory T cells which express inhibitory markers and are associated with metastasisChester Lai

472MicroRNA-130a: a tumor suppressive miRNA in cutaneous squamous cell carcinomaWarangkana Lohcharoenkal

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516The diagnostic and prognostic value of five blood markers in cutaneous T-cell lymphomas: a validation cohortGabor Dobos

Poster Walk 20 (Kiosk 10)Photobiology

Leader: Rachel Watson

098Retinoids in the treatment of skin photoageing: A histological study of topical all-trans retinoic acid efficacy in black skinAbigail Langton

541Solar simulated radiation induces loss of claudin – 1 from primary human keratinocytes: a mechanistic studyAbdulaziz Alhasaniah

542Xeroderma Pigmentosum C mutations increase oxidative DNA damages by inhibiting Base Excision Repair System’s expression and activityNour Fayyad

543The molecular effects of low dose (20 J/cm2) UVA1 on darker skin types of humanNoori Kim

550In vitro delivery of CPD-specific photolyase-encoding mRNA prevents UVB-induced mitochondrial changesCsaba Hegedus

551Involvement of sensory nerves in the development of focal alopecia and poliosis in miceZachary Chow

Poster Walk 21 (Kiosk 01)Inflammation, Immunity and Infection 7: Innate immunity and skin Inflammation

Leader: Katia Boniface

030Etrasimod, an oral, selective sphingosine 1-phosphate receptor modulator improves skin inflammation in a contact hypersensitivity dermatitis modelCatherine Crosby

035CD4+ resident memory T cells colocalize with CD301b+ dendritic cells in perifollicular lymphocyte clusters in a murine delayed-type hypersensitivity modelRyota Asahina

046Vitamin D3 promotes human Th2 responses by TSLP-dependent and -independent regulation of dendritic cellsAdrien Brulefert

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334Involvement of cathepsin S and protease-activated receptor-2 in ciguatoxin-induced substance P release: new promising targets to treat ciguatera pruritusOphélie Pierre

343Tissue factor expressed on monocytes induces inter-cellular gap formation of vascular endothelial cells via the extrinsic blood coagulation cascadeRyo Saito

344Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2Bin Peng

Poster Walk 22 (Kiosk 02)Inflammation, Immunity and Infection 8: Psoriasis

Leader: Curdin Conrad

004Ruxolitinib Cream Suppresses Inflammation in Adult Mild to Moderate Psoriasis PatientsMichael Howell

025Imiquimod-induced psoriatic inflammation can be attenuated by the application of a Liver X receptor agonist through the production of pro-resolution moleculeMasayuki Otsuka

027IgA plasma levels, but not IgG, against Streptococcus pyogenes identifies Anti-Streptolysin O negative chronic plaque psoriasis patients with increased specific CLA+ T cells IL17A and IL17F producersCarmen De Jesús-Gil

066Streptococcus pyogenes specific IgG, but not IgA, identifies guttate psoriasis patients with increased CLA+ T cells IL17A, IL17F and IL9 productersLuis Santamaria-Babi

391Ruxolitinib cream is highly effective at modulating a humanised rodent model of psoriasis vulgarisMelissa Parker

425Immunomodulation of skin inflammation by P28GST, a helminth parasite-derived protein, in a murine model of psoriasisAurélien Pagny

Poster Walk 23 (Kiosk 03)Inflammation, Immunity and Infection 9: Bacteria, viruses and fungal

Leader: Julien Seneschal

057Implication of Human Papilloma Virus (HPV) 16 in the non-erosive form of lichen planusNicolas Fazilleau

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076Skin tissue resident memory T cells in HIV infectionSimona Saluzzo

382Infection by dermatophytes of reconstructed human epidermis is impaired by PD169316 via inhibition of fungal growthEmilie Faway

383Distinguishable bacterial and fungal dysbiosis in skin of patients with Atopic Dermatitis or Netherton SyndromeSandrine Dubrac

408Skin colonized Staphylococcus aureus exacerbates the inflammation of murine irritant contact dermatitis via modulating innate immune pathwaysMasashi Iwata

626Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunityKiarash Khosrotehrani

Poster Walk 24 (Kiosk 04)Inflammation, Immunity and Infection 10: Systemic Sclerosis, Dermatomyositis, Lupus

Leader: Jean-David Bouaziz

015Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stressAkiko Sekiguchi

034Characterization of novel TMEM173 mutation causing a lupus- and SAVI-like phenotype, modified by polymorphisms in TMEM173 and IFIH1Annamari Ranki

042MDA5+ dermatomyositis is associated with stronger skin type I interferon transcriptomic signature with up-regulation of IFN-κ transcriptCharles Cassius

043Persistent deficiency of mucosal associated invariant T cells in dermatomyositisCharles Cassius

045Role of effector and regulatory B cells in patients with systemic sclerosis: IL-6 producing effector B cells associated with skin fibrosisTakashi Matsushita

540Decreased CCN3 expression in Systemic Sclerosis skin contributes to vasculopathy and links to pigmentary disordersMuriel Cario

91

Poster Walk 25 (Kiosk 05)Clinical Research and Epidemiology 1: Atopic Dermatitis, Allergy, Itch

Leader: Alain Taïeb

089Atopic dermatitis is associated with an increased risk of autoimmune diseases: a population-based cohort study using UK primary care dataHelen Alexander

101Dupilumab improves outcomes of concurrent asthma and chronic Sino-Nasal conditions in patients with atopic dermatitis – a pooled analysis of four phase 3 studies (LIBERTY AD SOLO 1 & 2, CHRONOS, and CAFÉ)Mark Boguniewicz

102Dupilumab decreases Staphylococcus aureus colonization and increases microbial diversity in patients with atopic dermatitisChris Callewaert

106BLU-5937, a potent and selective P2X3 Antagonist, for the treatment of chronic itch: evidence from pre-clinical studiesDenis Garceau

127TREATGermany registry: “real-world effectiveness” of dupilumab in atopic dermatitisDora Stölzl

145Establishment of wheat peroxidase I-specific IgE test to identify wheat-dependent exercise-induced anaphylaxis developed by sensitization to grass pollenEishin Morita

Poster Walk 26 (Kiosk 06)Epidermal Structure and Function: Barrier

Leader: Yves Poumay

197Functional assessment of the atopic eczema candidate gene EMSY identifies a role in skin barrier formationMartina Elias

213Ahed plays crucial roles in growth and differentiation of epidermal keratinocytesMikiro Takaishi

237Skin barrier integrity is enhanced after topical application of emulsions with an acidic pHEhrhardt Proksch

262A spatially resolved proteomic atlas of human skin and its associated immune systemBeatrice Dyring-Andersen

273IQGAP proteins in psoriasis: is it only about scaffold?Alena Zolotarenko

92

583Selective epidermal removal is a robust platform for understanding context-dependent epithelial cell activationYu Fujimura

Poster Walk 27 (Kiosk 07)Genetics and Cell Based Therapy 2: Epidermolysis bullosa

Leader: Cristina Has

287Safety and early efficacy outcomes for lentiviral fibroblast gene therapy for recessive dystrophic epidermolysis bullosaSu Lwin

295Donor-dependent variation and bias of transforming growth factor-β activating mechanisms in recessive dystrophic epidermolysis bullosaEijiro Akasaka

307Homozygous Biallelic KRT5 Mutations in Epidermolysis Bullosa Simplex, Including a Complete Human Keratin 5 “Knock-Out”, in Families with Extensive ConsanguinityJouni Uitto

312CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cellsJoanna Jackow

584Footprint-free gene mutation correction in induced pluripotent stem cell (iPSC) derived from recessive dystrophic epidermolysis bullosa (RDEB) using CRISPR/Cas9 and piggyBac transposon systemMunenari Itoh

631Oxidative stress imbalance as contributing factor in the establishment of fibrosis in recessive dystrophic epidermolysis bullosaEsteban Chacón-Solano

Poster Walk 28 (Kiosk 08)Hair follicle and skin appenages

Leader: Ralf Paus

594Skin Vasculature And Hair Follicle Stem Cells Cross-talking Associated With Stem Cell Activation And Tissue HomeostasisTudorita (Doina) Tumbar

597Outer root sheath is able to synthesise glycogen from lactate-investigating glycogen metabolism in human hair folliclesKatarzyna Figlak

93

599PPARg signaling modulation protects from hair follicle bulge stem cell damage and cyclophosphamide-induced hair follicle cytotoxicityMarta Bertolini

601Digital histological image analysis underpins the role of immune privilege collapse in the sweat glands in the etiopathogenesis of syringotropic autoimmune diseasesYurie Shimoda

607The putative tribbles homolog 3 (TRIB3) activator honokiol suppresses lipogenesis, and exerts anti-proliferative as well as anti-inflammatory effects on human sebocytesAttila Oláh

613Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivoIlaria Piccini

Poster Walk 29 (Kiosk 09)Melanoma and other Skin Cancers 5: Melanoma, Non melanoma skin cancers

Leader: Hamid Rezvani

115Hexylaminolevulinate and Aminolevulinic acid Nanoemulsion have Similar Tolerability, Initial Efficacy and Cosmetic Outcome as Methylaminolevulinate in Photodynamic Therapy of Basal Cell Carcinoma in a Prospective Randomized Double-blinded TrialMari Salmivuori

119Cyclooxygenase-2 Inhibitor Use and Risk of Skin Cancer: Three Prospective Cohort StudiesHsi Yen

125The Epidemiology and Clinical Characteristics of Extramammary Paget Disease Patients in Canada and Assessing the Risk of Second MalignanciesFeras Ghazawi

129Detection of high-risk human papillomavirus in nail squamous cell carcinoma and comprehensive analyses of 136 cases from the literature: The implications for high-risk human papillomavirus reservoir and sexually transmitted infectionAkira Shimizu

443Mechanisms of Keratinocyte-Melanoma Cell InteractionSabine Spänig

458An intuitive explanation of dermoscopic structures by digitally reconstructed pathological top-down view and 3D imagesAkira Kasuya

94

Poster Walk 30 (Kiosk 10)Melanoma and other Skin Cancers: Therapy

Leader: Cornelia Mauch

023Senescence surveillance maintains genomic and functional differentiation in pre-malignant tumorsMartin Röcken

386Senescence induces pro-apoptotic features in tumor cells enabling targeted senolysis by type I immune-mediators and subsequent phagocytic clearanceKatharina Böhm

397The role of Keratins in modulating carcinogenesis via communication with cells of the immune systemInes Sequeira

423Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal CancerStephen Murtough

452Neural networks detect cutaneous basal cell carcinomas in histological sectionsSusanne Kimeswenger

457Cancer associated fibroblast profiling reveals endothelin signalling as a novel mediator of niche to tumour cross-talk in Basal Cell CarcinomaEdwige Roy

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Meeting Organisers

LOCAL ORGANISING COMMITTEEAlain Taïeb (Chair)Katia BonifaceJulien Seneschal

ESDR OFFICE

Thomas Florestan Executive Director

Caroline Blondel Baldassarre Corporate Relations Manager

Valérie Aulas Membership Co-ordinator

Mounia Heddad Masson Educational Platform Manager

7 Rue CingriaCH-1205 Geneva SwitzerlandT: +41 22 321 48 90F: +41 22 321 48 92E: [email protected]: www.esdr.org

2019 ESDR SCIENTIFIC PROGRAM COMMITTEECaterina Missero (Chair)Katia BonifaceSabine Eming Michel Gilliet Chris Griffiths David Kelsell Eli Sprecher Marta SzellEdel O’Toole

PROFESSIONAL CONGRESS ORGANISER C-INProfessional Congress Event Organiser Prague Congress Centre5. května 65CZ-140 00, Prague 4

96

2019 Birgit Lane (Singapore) Erwin Tschachler (Austria)

2018 Peter Elias (US) Barbara Gilchrest (US) Carlo Pincelli (Italy)

2017 Sarolta Kárpáti (Hungary) Irene Leigh (UK) Yoshiki Tokura (Japan)

2016 Jens-M Schröder (Germany) Giovanna Zambruno (Italy)

2015 Leena Bruckner-Tuderman (Germany) Masayuki Amagai (Japan)

2014 Robin Eady (UK) Wolfram Sterry (Germany)

2013 Peter van de Kerkhof (Netherlands) Ronald Marks (UK) Hiroshi Shimizu (Japan)

2012 Johannes Ring (Germany)

2011 Paul Bergstresser (USA) Koji Hashimoto (Japan) Anders Vahlquist (Sweden)

2010 Alberto Giannetti (Italy) Shinji Shimada (Japan)

2009 Ervin Epstein (USA) Peter Friedmann (UK)

2008 William Cunliffe (UK) Kristian Thestrup-Pedersen (Denmark)

2007 Thomas Krieg (Germany) John Stanley (USA)

2006 RRona MacKie (UK) Rein Willemze (Netherlands)

2003 Georg Stingl (Austria) Jouni Uitto (USA)

2000 Malcolm Greaves (UK) Egon Macher (Germany)

1999 Stefania Jablonska (Poland) Hiroaki Ueki (Japan)

1998 Takeji Nishikawa (Japan) John Voorhees (USA)

1996 Enno Christophers (Germany) Sadao Imamura (Japan) Steve Katz (USA) Willem van Vloten (Netherlands)

Previously awarded

Otto Braun-Falco (Germany) Robert Brun (Switzerland) Rudi Cormane (Netherlands) André Kint (Belgium) Charles Lapière (Belgium) Kimmo Mustakallio (Finland) Michel Prunieras (France) Hans Rorsman (Sweden) Ferdinando Serri (Italy) Sam Shuster (UK) Klaus Wolff (Austria)

ESDR HONORARY MEMBERS AND AWARDS

YEAR HONORARY MEMBERS

2019 ESDR ABSTRACT REVIEWERS

Hervé BachelezSara BrownEnzo Calautti John Connelly Emmanuel Contassot Antonio Costanzo Wim Declercq Leopold Eckhart Kilian Eyerich Hiva Fassihi Carsten Flohr Olivier Gaide

Michel Gilliet Cristina Has Bernhard HomeyAlain Hovnanian Sandra IdenDelphine JavelaudVeli-Matti Kähäri York Kamenisch David Kelsell Lionel LarueFelix LaufferRalf Ludwig

Thierry MagnaldoAndrei MardaryevJohn McGrathCaterina Missero Alex Navarini Catherin Niemann Carien NiessenEdel O’TooleThierry Passeron Ralf PausChristoph SchlapbachMatthias Schmuth

Lone Skov Eli SprecherKaisa Tasanen-MäättäDes Tobin Erwin Tschachler Thomas Tuting Thomas WerfelSara Wickström Norbert Wikonkal Antony YoungPaola Zigrino

ABOUT THE ESDR

97

FUTURE ESDR MEETINGS

Executive Committee

PresidentDavid Kelsell

President ElectChristopher Griffiths

Secretary-TreasurerChristopher Griffiths

Secretary-Treasurer ElectHervé Bachelez

Past-presidentMichel Gilliet

Board membersLeopold Eckhart Sabine Eming Bernhard HomeyCaterina MisseroEdel O’Toole Sirkku PeltonenMenno De Rie Julien Seneschal Eli SprecherMarta SzellThomas Tuting

CURRENT ESDR EXECUTIVE COMMITTEE AND BOARD

ESDR PATRON MEMBERSESDR Patron Members support the society through increased annual membership dues. The ESDR would like to thank the following Patron Members for their valuable support.

Salvador Aznar-BenitahMartine BagotJonathan BarkerZsuzsanna Bata-CsorgoJohann W BauerTilo BiedermannIda BramsAlexander EnkLars E FrenchOlivier GaideMichel GillietGiammaria GiulianiChristopher E.M. GriffithsEugene HealyAlain HovnanianChristian HunefeldRoland KaufmannDavid Kelsell

Birgit LaneAntti LauermaLotus MallbrisLudovic MartinCornelia MauchDedee F MurrellNiels OdumMauro M. PicardoGerd PlewigNick ReynoldsMartin RoeckenMatthias SchmuthThomas SchwarzMona StahlePeter M SteijlenGeorg StinglSandra TrompezinskiErwin Tschachler

202050th Annual ESDR Meeting Amsterdam, The Netherlands 2–5 September 2020

PHOTO CREDITS

Inside back cover:‘Sandra’, from the series ‘Surfaces’, 2018© Justine Tjallinks / Courtesy of KahmannGallery Amsterdam

Outside back cover:‘Doriano’, from the series ‘Surfaces’, 2018© Justine Tjallinks / Courtesy of KahmannGallery Amsterdam

98

YEAR PRESIDENT SECRETARY TREASURER

1971 F. Serri M. Prunieras R. Cormane1972 O. Braun-Falco M. Prunieras R. Cormane1973 S. Shuster M. Prunieras R. Cormane1974 H. Rorsman M. Prunieras R. Cormane1975 R. Cormane C. Lapière E. Christophers1976 K. Wolff C. Lapière E. Christophers1977 E. Jung C. Lapière E. Christophers1978 E. Christophers M. Greaves T. van Joost1979 R. Marks M. Greaves W. van Vloten1980 H. Schaefer M. Greaves W. van Vloten1981 E. Frenk M. Greaves W. van Vloten1982 M. Greaves H. Hönigsmann W. van Vloten1983 G. Plewig H. Hönigsmann W. van Vloten1984 W. van Vloten H. Hönigsmann B. Vermeer1985 A. Giannetti W. J. Cunliffe B. Vermeer1986 J. H. Saurat W. J. Cunliffe B. Vermeer1987 P. Fritsch W. J. Cunliffe B. Vermeer1988 W. J. Cunliffe G. L. Vejlsgaard R. Willemze1989 B. Vermeer G. L. Vejlsgaard R. Willemze1990 J. Ring G. L. Vejlsgaard R. Willemze1991 G. L. Vejlsgaard P. S. Friedmann R. Willemze1992 D. M. MacDonald P. S. Friedmann R. Willemze1993 G. Stingl P. S. Friedmann R. Willemze1994 P. S. Friedmann W. Sterry P. van de Kerkhof1995 T. Krieg W. Sterry P. van de Kerkhof

YEAR PRESIDENT SECRETARY-TREASURER

1996 W. Sterry P. van de Kerkhof1997 K. Thestrup-Pedersen P. van de Kerkhof1998 R. Camp P. van de Kerkhof1999 P. van de Kerkhof L. Bruckner-Tuderman2000 I. Leigh L. Bruckner-Tuderman2001 G. Zambruno L. Bruckner-Tuderman2002 L. Bruckner-Tuderman L. French2003 J. Rees L. French2004 M. Röcken L. French2005 L. French M. Röcken2006 T. Schwarz M. Röcken2007 C. Pincelli M. Röcken2008 J. McGrath V. Piguet2009 R. Dummer V. Piguet2010 E. Healy V. Piguet2011 V. Piguet A. Enk2012 T. Biedermann A. Enk2013 A. Enk J. Barker2014 N. Reynolds J. Barker2015 M. Picardo J. Barker2016 J. Barker M. Gilliet2017 M. Schmuth M. Gilliet 2018 M. Gilliet C- Griffiths

PAST OFFICERS OF THE ESDR BOARD

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Notes

50th Annual ESDR Meeting2–5 September 2020

Amsterdam

www.esdrmeeting.org

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