Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059
description
Transcript of Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059
Cell Biology Cell Biology 1010
- Review- Review
Cell Biology Cell Biology 1010
- Review- Review
Sung Youn Lee, PhD. StudentSung Youn Lee, PhD. StudentVeterinary collage, Room 320Veterinary collage, Room 32002 450 3719, 016 293 605902 450 3719, 016 293 6059
[email protected]@paran.com
Schwann cell-PNS
Oligodendrocyte-CNS
To groove
Allowing the myosin heads to make contact with the released sites of the actin monomer
Fast axonal transport is a major form of motility for secretory and membran
ous components• Average rate ; 250~400mm/day• Membrane associated
– Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)
hsp70 released byATP hydrolysis
Positively charged, NH2-, 20-80 a.a.s
Signal peptide cleavedThen protein folds
From free ribosome
ATP hydrolysisfor protein folding
hsp70 released byATP hydrolysis
Integral Intermembrane space
Nerve growth factor• NGF binds to NGF receptors on the growth c
ones of approaching axons.• It is internalized by receptor mediated endocyt
osis and transported retrogradely to the cell body, where it undergoes lysosomal degradation.
• NGF supports the survival of cholinergic nerons.– Alzheimer disease (cholinergic neuron for memory)
Nerve growth factor• Lou Gehrig’s disease• = ALS (amyotrophic lateral sclerosis)• CNTF (ciliary neurotrophic factor)
– PNS : schwann cell– CNS : astrocyte– Cf. other neurotrophic factors are secreted by targ
et cell (muscle cell)– --> motor neuron ▽--> muscle▽
Ach
EpinehprineNorepinephrine
Ach Ach