Cell Biology Cell Biology 1010
- Review- Review
Cell Biology Cell Biology 1010
- Review- Review
Sung Youn Lee, PhD. StudentSung Youn Lee, PhD. StudentVeterinary collage, Room 320Veterinary collage, Room 32002 450 3719, 016 293 605902 450 3719, 016 293 6059
[email protected]@paran.com
Schwann cell-PNS
Oligodendrocyte-CNS
To groove
Allowing the myosin heads to make contact with the released sites of the actin monomer
Fast axonal transport is a major form of motility for secretory and membran
ous components• Average rate ; 250~400mm/day• Membrane associated
– Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)
hsp70 released byATP hydrolysis
Positively charged, NH2-, 20-80 a.a.s
Signal peptide cleavedThen protein folds
From free ribosome
ATP hydrolysisfor protein folding
hsp70 released byATP hydrolysis
Integral Intermembrane space
Nerve growth factor• NGF binds to NGF receptors on the growth c
ones of approaching axons.• It is internalized by receptor mediated endocyt
osis and transported retrogradely to the cell body, where it undergoes lysosomal degradation.
• NGF supports the survival of cholinergic nerons.– Alzheimer disease (cholinergic neuron for memory)
Nerve growth factor• Lou Gehrig’s disease• = ALS (amyotrophic lateral sclerosis)• CNTF (ciliary neurotrophic factor)
– PNS : schwann cell– CNS : astrocyte– Cf. other neurotrophic factors are secreted by targ
et cell (muscle cell)– --> motor neuron ▽--> muscle▽
Ach
EpinehprineNorepinephrine
Ach Ach
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