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Project Phase I

04/20/2023

Dept. of Electronics Engg. Pondicherry University

“A CMOS Diaphragm Based Label-Free DNA SoC Detection with Improved Sensitivity & Efficiency”

Presented by: Under The Guidance of

Shabaz Ahmed Sheikh.SSDr T Shanmuganantham

M Tech [Electronics], 2nd Year Asst.Professor

12304013

Dept Of Electronics Engineering,

Pondicherry University,

Puducherry

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Out Line

04/20/2023Dept. of Electronics Engg. Pondicherry University

oMotivation oObjectiveoExisting ModeloProblems In Existing ModeloProposed ModeloExpected improvement in proposed modeloWork PlanoReferences

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Motivation

04/20/2023Dept. of Electronics Engg. Pondicherry University

DEOXYRIBONUCLEIC acid (DNA) detection is an important analytical method in molecular biology, and it finds a wide range of applications from genetic disease diagnostics, medicine and drug discovery, to forensic investigation and food testing, etc.

This way we can and will be able to diagnose and detect the fatal diseases like HEPATITIS, CANCER, TB hands on without any special technique required .

This if done on a large scale can bring down the cost of this Lab-On-Chip device drastically and will be boon to the mankind.

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Objective

04/20/2023Dept. of Electronics Engg. Pondicherry University

To design a CMOS Diaphragm Based Label-Free DNA SoC Detection with Improved Sensitivity & Efficiency

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Existing Model

04/20/2023Dept. of Electronics Engg. Pondicherry University

04/20/2023Dept. of Electronics Engg. Pondicherry University

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Existing Model Contd………

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Problems In Existing Model

04/20/2023Dept. of Electronics Engg. Pondicherry University

Resistance based .(piezoresistive)Sensitivity can further be improved.Interference due to unspecific binding.Communication/data rate to external wireless can be

improved.Power consumption can further be reduced.

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Proposed model

04/20/2023Dept. of Electronics Engg. Pondicherry University

Capacitance based,i.e diaphragm will be used by iterating different material combinations

Resistance to frequency converter will be replaced by capacitive converter

QPSK system will be used instead of OOK for external communication

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Expected Improvements In Proposed Model

04/20/2023Dept. of Electronics Engg. Pondicherry University

Better sensitivity and detectionLower power consumptionHigher data rate

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04/20/2023Dept. of Electronics Engg. Pondicherry University

Task Subtask Duration Expected Result

T1: Definition and plan Problem definition, methodology and work plan

July1-july25 Study of A CMOS Membrane/Diaphragm Based Label-Free DNA SoC Detection

T2: Application Identifying the applications July26-August10 Easy disease diagnosis eg. CANCER,HEPATITIS,TB, Avian Flu

T3: Proposal of A CMOS diaphragm based label-free DNA soc detection with improved sensitivity & efficiency

T3.1:Theoretical analysis of existing model

August11- August 30 The methodology of design new capacitance or membrane based DNA detection

T4: Simulations

T4.1: Choice of simulation tool

August 31- September 10 Description about the tool to simulate the model

T4.2: Simulation conditions

Sept 11- Oct 1 The parameters and the values of input voltage used to simulate the model

T4.3: Simulations of the proposed model.

Oct 02- Oct 15 The expected result for proposed model

T5: Presentations/submissions T5.1: Report 1

Oct 25 - Nov 25 Report submission for the work so far done

T5.2: viva 1 Nov 9- Nov 30 Explanations for the queries regarding the work so far done

Work Plan

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References

04/20/2023Dept. of Electronics Engg. Pondicherry University

[1] Y.-J. Huang, C.-T. Lin, L.-G. Chen, P.-Y. Hsiao, B.-R.Wu, H.-T. Hsueh, B.-J. Kuo, H.-H. Tsai, H.-H. Liao, Y.-Z. Juang, C.-K. Wang, and S.-S. Lu, “A fully-integrated cantilever-based DNA detection SoC in a CMOS bio MEMS process,” in Proc. IEEE Symp. VLSI Circuits, 2011, pp. 50–51. C.-W. Huang, T.-H. Lin,

[2] N. Gemma, S. O’uchi, H. Funaki, J. Okada, and S. Hongo, “CMOS integrated DNA chip for quantitative DNA analysis,” in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560–561.

[3] S.-J. Kim and E. Yoon, “Label-free CMOS biosensor with on-chip noise reduction scheme for real-time quantitative monitoring of biomolecules,” IEEE Trans. Biomed. Circuits Syst., vol. 6, no. 3, pp. 189–196, Jun. 2012.

[4] N. Lajnef, S. Chakrabartty, N. Elvin, and A. Elvin, “Piezo-powered floating gate injector for self-powered fatigue monitoring in biomechanical implants,” in Proc. IEEE Int. Symp. Circuits and Systems, 2007, pp. 89–92.

[5] N. Gemma, S. O’uchi, H. Funaki, J. Okada, and S. Hongo, “CMOS integrated DNA chip for quantitative DNA analysis,” in Proc. IEEE Int. Solid-State Circuits Conf., Dig. Tech. Papers, 2006, pp. 560–561.

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04/20/2023Dept. of Electronics Engg. Pondicherry University

QUERIES

IF ANY ?

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04/20/2023Dept. of Electronics Engg. Pondicherry University

Thank You