Rob Edgecock STFC Rutherford Appleton Laboratory · STFC Rutherford Appleton Laboratory. Outline...
Transcript of Rob Edgecock STFC Rutherford Appleton Laboratory · STFC Rutherford Appleton Laboratory. Outline...
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Introduction to FFAGs
Rob Edgecock
STFC Rutherford Appleton Laboratory
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Outline
• Treatments
• Radiotherapy
• Charged particle therapy
Cancer therapy
Focus on particle accelerators
• Introduction to accelerators
• Accelerator applications
Advantages of FFAGs for these applications
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Particle Accelerators
• Used to increase KE/momentum of charged particles
• All charged particles accelerated: e-, p+, H-, ionsn+
• Acceleration via electric fields
• DC........electrostatic acceleration: cathode ray tubevoltage multiplier van der Graaff generator etc
• Energy limited by electrical breakdown
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John Cockcroft & Ernest Walton
Voltage Multiplier
Cavendish Laboratory, 1932.
1897 – J.J. Thomson
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Particle Accelerators
Van der Graaff generator
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Particle Accelerators
+ - ++ ++ --
Alternating Radio Frequency voltage.
Each step gives a small energy increase
to the particle.
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Particle Accelerators
Linear accelerator.Easier to design & operate.
But expensive at higher energies.
400 MeV p+ linac at Fermilab
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Particle Accelerators
“Circular” accelerators:1st type: cyclotrons
8
First circular particle accelerator built by Ernest O. Lawrence & Stanley Livingston at
Berkeley in 1930.
Energy = 80 keV, Diameter = 13cm
PSI cyclotron
600MeV
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Particle Accelerators
“Circular” accelerators:2nd type: synchrotrons
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Particle Accelerators
10
Sextupole (LEP)
Correction of chromatic
spread.
Quadrupole (LEP)Alternating Gradient
or Strong Focussing
Beam alternately
focussed in horiz
and vert planes.
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Particle Accelerators
NIMROD: 7 GeV weak focussing
synchrotronBevatron: 6.2 GeV LBNL
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Particle Accelerators
“Circular” accelerators:2nd type: synchrotrons
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Accelerator Applications
• Accelerators created for Particle Physics
• Many developments driven by PP
• Now used for other applications
>30000 accelerators already in use around the World
Annual sales: >$3.5B
Annual product, etc, sales: >$0.5T
Fit into a few broad categories:
• Energy
• Environment
• Healthcare
• Industry
• Security and defence
• Research
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Applications
>30000 accelerators in use world-wide:
44% for radiotherapy
41% for ion implantation
9% for industrial applications
4% low energy research
1% medical isotope production
<1% research
Treating cancerMaking better
semi-conductors
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Applications
>30000 accelerators in use world-wide:
44% for radiotherapy
41% for ion implantation
9% for industrial applications
4% low energy research
1% medical isotope production
<1% research
“Curing” materials;sterilisation;
carbon dating; treating flue gases;
treating water; etc
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Applications
>30000 accelerators in use world-wide:
44% for radiotherapy
41% for ion implantation
9% for industrial applications
4% low energy research
1% medical isotope production
<1% research
Microanalysis of materials, mass spectroscopy,
PIXE, etc
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Applications
>30000 accelerators in use world-wide:
44% for radiotherapy
41% for ion implantation
9% for industrial applications
4% low energy research
1% medical isotope production
<1% research
For PET and SPECT medical imaging, etc
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Applications
>30000 accelerators in use world-wide:
44% for radiotherapy
41% for ion implantation
9% for industrial applications
4% low energy research
1% medical isotope production
<1% research
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Physicists Introduction to Cancer
It starts with mutations of a single cell typically 6 are required to make it cancerous
• Mutations accumulateover time
• Can occur by accident
• Usually requires a “carcinogen”
tobacco (50)other chemicalsradiation (e.g. sun)
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Some Statistics
• >300k new cases/year in the UK
• >1 in 3 people will suffer from it
• 1 in 4 deaths result from it
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Treatments
Three main types:surgeryradiotherapychemotherapy
• Cancer therapy: It’s all about minimising collateral damage!
• Killing or removing just cancerous cells
• Damage to healthy cells leads to side-effects
Three main types:surgeryradiotherapychemotherapy
• Uses beams of ionising radiation
• Mainly X-rays, but see later
• Usually produced externally and directed onto tumour
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Radiotherapy
Ionisation from radiation kills cells in two ways
Multiple DNA chain breaks preferred
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Radiotherapy
• “Standard” radiotherapy uses X-rays
• Created using electron linear accelerator
• Energy ~4-20 MeV
• X-rays produced in metal foil
• Typical treatment: ~60Gy
• Delivered in “fractions” of ~2Gy
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Beam Delivery
• Old technique: treat whole tumour in one go
• Newer technique: Intensity Modulated Radiotherapy
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Varian: IGRT
Dose Localisation
CyberKnife
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Dose Localisation
Second most successful
treatment after surgery!
Damage to healthy tissue: side-effects!
But……... healthy cells have more
repair mechanisms…
Fractions and IMRT
It’s possible to do better!
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Dose Localisation
Second most successful
treatment after surgery!
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Dose Localisation
100%
60%
10%
Medulloblastoma in a
child (MD Anderson)
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Proton Therapy
10-20 x cost
Under construction:2016: 182017: 62018: 6
In planning:16
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Proton Therapy
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Proton Therapy
protonGuys.com
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Other Ions
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Dose Localisation
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Dose Localisation
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Dose Localisation
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Charged Particle Therapy
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Carbon Therapy
• In operation:Europe: 3China: 2Japan: 5
• Construction:Europe: 1China: 1South Korea: 1
• Significant PP input to those in Europe
• Two based on CERN design
• Main problem: size!
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Roles of FFAGs
Fixed Field Alternating Gradient accelerator
Cyclotron-like
• Combines features of cyclotrons and synchrotrons
• Interesting for particle therapy, ADSR, PP and others
• Particularly in intermediate energy range
Synchrotron-like
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A Brief History of FFAGs
• 1950s/60s: most extensive work at MURA
20 to 400 keV machine
Operated at MURA in 1956
Bohr
Chandrasekhar
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A Brief History of FFAGs
Spiral sector machine
Operated at MURA in 1957
• 1950s/60s: most extensive work at MURA
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A Brief History of FFAGs
100keV to 50MeV machine
Operated at MURA in 1961
• 1950s/60s: most extensive work at MURA
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A Brief History of FFAGs
• Invented in 1950s: 3 electron machines built, to 50 MeV
• Proton proposals failed: technical complexity/energy
• Re-invented late 1990’s in Japan for muon acceleration- ideal due to high acceptance & very rapid cycling- for a Neutrino Factory- first proton PoP FFAG built, 500 keV, 2000- 2nd proton FFAG, 150 MeV, 2003- prototype for proton therapy- various other machines built
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(Non-scaling) FFAG Development
• Originally invented for:
fast acceleration
large DA
• 2004:
studies for applications
unique features
needed to build one
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EMMA
Section of ALICE
Injection line: transports beam from ALICE to EMMA
EMMA ring: beam makes 5 to 100+ turns in this
Diagnostics beam line
Proof-of-principle: cheapest option!
Electron acceleration: 10 to 20 MeV
Built in DL
Now finished
5.25m
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EMMA
Works!Proved the principle of this type of
accelerator
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PAMELA
• Being done in parallel to EMMA
• NS-FFAG carbon ion and proton therapy facility:
250 MeV protons
400 MeV/u carbon ions
gantry(ies), with spot scanning
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PAMELA
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More recent developments
• New FFAG design
• More cyclotron-like
fixed RF frequency
very high beam currents
• Carbon therapy
Fixed Field Alternating
Gradient accelerator
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Carbon therapy
135 tons
2 tons
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Others
• Radioisotope production
10-30 MeV
20mA: >20 times existing cyclotrons
• Accelerator Driven Systems (ADS)
MYRRHA project, Belgium
FFAG equivalent.
Much less well developed, but
much cheaper to have
redundancy
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Conclusions
• Non-scaling FFAGs:
Unique form of accelerator
Combine features of cyclotrons and synchrotrons
More flexible than other circular accelerators
• World’s first machine built in DL
• Being developed for:
particle physics: muon and proton acceleration
cancer therapy: with electrons (x-rays), protons,carbon ions, neutrons (BNCT)
energy generation: ADSR
• One of few places in accelerator R&D that UK has lead