Pulmonary Embolism Dr Felix Woodhead Consultant Respiratory Physician.
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Transcript of Pulmonary Embolism Dr Felix Woodhead Consultant Respiratory Physician.
![Page 1: Pulmonary Embolism Dr Felix Woodhead Consultant Respiratory Physician.](https://reader035.fdocuments.net/reader035/viewer/2022080915/56649d8c5503460f94a74687/html5/thumbnails/1.jpg)
Pulmonary EmbolismDr Felix Woodhead
Consultant Respiratory Physician
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Pulmonary Embolism
• Part of VTE
• Potentially fatal
• Can complicate hospital admission
• Preventable
• Tests poor
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Risk factors
• Surgery– Abdominal
– Lower limb
• Obstetric
• Malignancy
• Previous VTE
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Clinical Probability
• Wells score
• Geneva criteria
• Is a major risk factor present? =1
• Is there no other explanation? =1
• Score:– 2: High probability
– 1: Intermediate probability
– 0: Low probability
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D-dimer
• Only useful if NEGATIVE
• ↑ by many things (including pregnancy and infection)
• Used only after assessment of clinical probability– Not used if high clinical probability
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Imaging
• CTPA in most places
• V/Q – only if normal CXR and no cardiopulmonary disease
– Intermediate scan requires follow-up imaging (CTPA)
• Doppler USS if DVT (no need for resp imaging)
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Screening for thrombophilia/cancer
• Thrombophilic abnormality occurs in 25-50% VTE
• Usually interacts with environment (esp oestrogens), and risk is multiplicative
• Does not predict risk of recurrence
• Screen for cancer with bloods, clinical picture and CXR only
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Treatment
• Thrombolysis only in massive PE (circ collapse)
• Thrombolysis controversial if RV impairment
• Anticoagulate with LMWH then warfarin for– 4-6/52 if associated with temporary risk factor
– 3/12 if no risk factor (BTS), US recommend 6/12
• ?unfractionated heparin initial bolus
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Pulmonary Arterial HypertensionDr Felix Woodhead
Consultant Respiratory Physician
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Findings
• Exertional breathlessness
• Exertional chest pain and presyncope
• Normal radiology if idiopathic
• Normal PFTs if idiopathic
• ↑ systolic PAP on echo only if TR
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Defined by RHC
• mPAP – > 25 mmHg at rest (normal 12-16 mmHg)
– > 30 mmHg on exertion
• Cardiac Output
• Cardiac Index (=CO/height2)
• Pulmonary Vascular Resistance
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Causes• Left ventricular impairment (PCWP > 15)
– LVF
– Mitral valve disease
• Increased pulmonary blood flow (L→R shunt) → Eisenmenger’s syndrome
• Hypoxaemia (cor pulmonale)
• Chronic Thromboembolic (CTEPH)
• HIV
• CTD (SSc etc)
• Idiopathic (IPAH)
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Investigations
• PFTs
• CTPA
• Echo (± bubbles)
• 6 minute walk
• Right Heart Catheter
• (traditional) pulmonary angiogram
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Treatment• Treatment of associated causes
– LV disease
– O2 for cor pulmonale
• Warfarin (for all)
• Calcium channel blockers – little used now
• Endothelin receptor blockers – Bosentan, sitaxentan
• PDE4 antagonists – Sildenafil etc
• Prostaglandins
– Nebulised
– Continuous IV via Hickman line
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Sleep medicine
Dr Felix Woodhead
Consultant Respiratory Physician
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Obstructive sleep apnoea/hypopnoea Sx• Periodic reduction of airflow at night
• Caused by ostruction (cf central apnoea) due to reduced muscle tone in a suceptible airway (obesity)
• Apnoea : no airflow for 10 s
• Hypopnoea : ≤ 50% airflow in 10 s
• AHI (apnoea/hypopnoea index) = no of events/hr
• AHI
– 5-14 = mild
– 15-30 = moderate
– >30 = severe
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Symptoms
• Sleepiness (daytime hypersomnolence)– Epworth Sleepiness Score
• Witnessed apnoeas
• Nocturia
• Hypertension
• Reduced concentration
• Reduced libido
• Tendency to cor pulmonale, esp in COPD
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Diagnosis
• Overnight oximetry– Good screening esp in obese
– Cannot be used to exclude OSAHS
• Limited PSG– Useful initial test in young, non-obese
• Full PSG
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Treatment
• Only if symptomatic
• AHI >15, desat index >10/hr
• Nasal CPAP– fixed
– Autotitrating device
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Domiciliary NIV
• For ventilatory failure
• Other treatments
– Low flow O2 (with care)
– Treatment of sleep disordered breathing
• Hallmark of ventilatory failure is ↑pCO2