PTNS - update

MRVANBALKEN

5 NOV 2013

5 NOV 2013

5 NOV 2013

5 NOV 2013

5 NOV 2013

12 wekelijkse sessies

elke 2 weken

elke 3 weken

elke 4 weken

hellip

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

5 NOV 2013

5 NOV 2013

12 wekelijkse sessies

elke 2 weken

elke 3 weken

elke 4 weken

hellip

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

5 NOV 2013

12 wekelijkse sessies

elke 2 weken

elke 3 weken

elke 4 weken

hellip

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

12 wekelijkse sessies

elke 2 weken

elke 3 weken

elke 4 weken

hellip

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

12 wekelijkse sessies

elke 2 weken

elke 3 weken

elke 4 weken

hellip

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

PTNS-schema

PTNS 1 of beide benen

PTNS-stimulatieparameters

PTNS-indicaties

PTNS bij neurogeen blaaslijden

PTNS bij instabiliteiten

PTNS en andere behandelingen

PTNS-toekomst

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients

5 NOV 2013

Neurourol Urodyn 2013 Jun32(5)472-5 doi 101002nau22322 Epub 2012 Oct 15

Urgent-SQ implant in treatment of overactive bladder syndrome 9-year follow-up study

Janssen DA Farag F Heesakkers JPSource

Department of Urology Radboud University Nijmegen Medical Centre Geert Grooteplein Zuid Nijmegen

The Netherlands djanssenuroumcnnl

Abstract

AIMS

Electrical stimulation of the posterior tibial nerve (PTN) is an established therapy for the treatment of

refractory overactive bladder syndrome (OAB) The Urgent-SQtrade is an implant that is surgically placed near

the PTN and activated by an external pulse generator allowing for on demand PTN stimulation without the

need for needle insertion The current study presents results of a 9-year open-label follow-up of eight

patients to address the long term safety and efficacy of the implant

METHODS

In 2003 eight patients with refractory OAB received a Urgent-SQtrade implant and were systematically followed

up for 1 year After that the follow up continued as open-label study The seven patients who still had the

implant were contacted after 9 years and evaluated with an interview physical exam ankle X-ray voiding

diaries and completed questionnaires about adverse events performance efficacy safety and quality of life

(validated iQoL)

RESULTS

Six of the seven patients still had sensory and loco-motor responses on stimulation at 9-year follow-up

Three of four patients who had a successful treatment response at 1 year still use the device The fourth

patient restarted therapy The implants are intact with no migration andor displacement All patients reported

easy handling of the Urgent-SQtrade One patient reported sporadic spontaneous sensory responses One

patient reported occasional localized ankle discomfort

CONCLUSIONS

After 9 years of clinical experience we demonstrated that implant driven PTNS with the Urgent-SQtrade is a

safe therapy for OAB The implant has a long lifespan and is well tolerated by patients