NOTICE OF MAILING CHANGE 0 Check here ifyou wish to

discontinue receiving this publication

U.S. DEPARTMENT OF HFNTH AND HUMAN SERVICES

OFFICIAL UI’SINESS Penalty for Private b e , $300

The NIH Guide announces scientific initiatives and provides policy and administratlr,e information t o indivi­duals and organizations who need t o be kept informed o f opportunities, requirements. and changes in extra mural programs administeretl by the National Insritutes o f Health.

0Check here ifyour address has changed and you wish to con­tinue receiving this publication Make corrections below and mail this page to:

NIH Guide Distribution Center National Institutes of Health Rtmm B3BE07. Building 31 Bethesda, Maryland 20892

Postage & Fees Paid PHS/NIH/OD

VOL. 15, NO. 19 - SEPTEMBER 26, 1986

Vol. 15, No. 19, September 26, 1986

MOTICES

PILOT STUDY/DISSERTATION RESEARCH SUPPORT ..................................... 1 National Institute on AgingIndex: AGING

PATED ANNOUNCEMENTS (RFPs AND RFAs AVAILABLE)

CANCER COMMUNICATIONS SYSTEM RESEARCH (CCSR).................................. 2 National Cancer Institute Index: CANCER

DEVELOPMENTAL GRANTS FOR ALCOHOLISM TREATMENT ASSESSMENT RESEARCH .............4 National Institute on Alcohol Abuse and ALCOHOLISM Index: CANCER

ONGOING PROGRAM ANNOUNCEMENTS

POSTDOCTORAL TRAINING FOR RNs WITH AN EARNED DOCTORATE........................6 National Center for Nursing Research Index: NURSING RESEARCH

IMAGING TECHNOLOGY IN ALCOHOL RESEARCH..... ................................... 8 National Ipstitute on Alcohol Abuse and Alcoholism Index: ALCOHOL ABUSE .AND ALCOHOLISM

i Nr RESEARCH GRANTS ON ALCOHOL AND IMMUNOLOGY INCLUDING

ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)................................lOj National Institute on Alcohol Abuse and Alcoholism

Index: ALCOHOL ABUSE AND ALCOHOLISM

GENETIC ASPECTS OF SPEECH, LANGUAGE AND READING DISORDERS ..................... 1 1 National Institute of Neurological and Communicative

Disorders and Strokei National Institute of Child Health and Human DevelopmentIndex: NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE Index: CHILD HEALTH AND HUMAN DEVELOPMENT

our

NOTICE

PILOT STUDY/DISSERTATION RESEARCH SUPPORTc> P.T. 349 40; K.W. 0710010, 0780000, 1002019, 1014002

OFFICE OF BIOLOGICAL RESOURCES AND RESOURCE DEVELOPMENT

Nat iona l I n s t i t u t e on Aging

The Nat iona l I n s t i t u t e on Aging ( N I A ) f o r many yea r s has provided support f o r p i l o ts tudy and d i s s e r t a t i o n r e sea rch on aging by fu rn i sh ing l i m i t e d numbers o f animals free of charge f o r t h e s e purposes. The supply o f small numbers o f free animals through t h e p i l o t s tudy program is intended t o he lp support i n i t a l s t u d i e s t o i n v e s t i g a t e f e a s i b i l i t y o r e s t a b l i s h c r e d i b i l i t y t o a theo ry t o a l low p u r s u i t o f more d e t a i l e d s t u d i e s la ter . The d i s s e r t a t i o n s tudy program is intended t o provide some p a r t i a l support f o r graduate s tuden t s i n t e r e s t e d i n pursuing s t u d i e s i n t h e area o f r e sea rch on ag ing .

Ea r ly i n t h e 1970s it became obvious t h a t t h e a v a i l a b i l i t y o f appropr i a t e animal models w a s a major f a c t o r f o r t h e development o f much needed r e sea rch on ag ing . I n response t o t h i s c l e a r l y ev ident need, and i n r ecogn i t ion o f t h e fact t h a t many,perhaps most, i n v e s t i g a t o r s had n e i t h e r t h e f a c i l i t i e s nor t h e f iscal r e sources needed t o develop and maintain co lon ie s o f aged animals, N I A made p rov i s ion o f r e sources one of i t s h ighes t p r i o r i t i e s . The a v a i l a b i l i t y o f high q u a l i t y agedroden t s f o r conduct ing ag ing research has continued t o be a p r i o r i t y area f o r N I A .

S p e c i f i c pathogen-free rodent resources c u r r e n t l y a v a i l a b l e o r under developmentfrom N I A inc lude fou r rat and t e n mouse genotypes t h a t are r a i s e d i n b a r r i e r fac i l i t i es and range i n age from 3 to 36 months. Mouse genotypes c u r r e n t l ya v a i l a b l e are t h e inbred s t r a i n s A/HeNNia, B A L B I c N N i a , C B A I C a H N N i a , C57BL/6NNia and DBAI2NNia; hybr id s t o c k s o f B6C3FlNia(C57BL/6NNia X C 3 H / N N i a ) , B6D2FlNia (C57BLI6NNia X DBA/2NNia) and CB6FlNia(BALB/cNNia X C57BL/6NNia); t h e congenics t r a i n BALBIcAnNNia-nucnude); and an outbred s t o c k o f Swiss Webster. N I A c u r r e n t l yprovides one ra t genotype, t h e inbred F ischer 344 (F344NNia): however under development is a colony o f t h r e e a d d i t i o n a l genotypes; t h e inbred Brown Norway( B N / B i R i j N i a ) , and t h e r e c i p r o c a l FlNia hybr ids o f t h e F344 and BN c r o s s e s . For t h e s e l a t t e r t h r e e genotypes, t h e first cohor t s were en te red i n t o t h e ag ing colonyi n J u l y 1986; t h e r e f o r e , it w i l l be 1988 before aged animals w i l l be a v a i l a b l e . It would be very h e l p f u l i n e s t a b l i s h i n g appropr i a t e product ion l e v e l s o f t h e s e l a t t e r t h r e e genotypes i f r e sea rche r s i n t e r e s t e d i n us ing t h e s e new genotypes would inform N I A o f t h e i r i n t e r e s t and p o t e n t i a l needs.

ea A l l r oden t s are r e g u l a r l y monitored f o r gene t i c p u r i t y and h e a l t h s t a t u s . A n i m a l s are housed a t c o n t r a c t o r f a c i l i t i e s behind s p e c i f i c pathogen b a r r i e r s , maintained a t p l u s o r minus 2 degrees F and a r e fed N I H 31 d i e t (ad l i b i t u m ) . Cage p o s i t i o n on cage r acks are r o u t i n e l y r o t a t e d t o prevent r e t i n a l degenerat ion from f l u o r e s c e n t l i g h t i n g . Ad l i b i t u m access t o a c i d i f i e d , chor ina ted d r ink ing water is provided.A h e a l t h min i to r ing s ta tement f o r t h e room i n which animals w e r e r a i s e d accompanieseach shipment of animals . Even though NIA heav i ly subs id i zes t h i s program to make t h e s e animals more a f fo rdab le , t h e normal c o s t s are s t i l l cons iderable . The approximate cost of a 30-month o l d rat is $106 and 30-month old mouse is $47, p l u ssh ipping c o s t . These co lon ie s have been developed t o f a c i l i t a t e r e sea rch on aging,t h e r e f o r e , ho lde r s o f N I A g r a n t s always r ece ive f irst p r i o r i t y i n access t o animals .

E f fec t ive September 1, 1986 t h e N I A i n s t i t u t e d a change i n po l i cy regard ing t h e P i l o t Study Program. A s p rev ious ly s t a t e d , t h e i n t e n t o f t h i s program is t o make l i m i t e d numbers o f animals a v a i l a b l e free o f charge. Therefore , i n accordance wi th t h i s goa l , animals f o r p i l o t s t u d i e s w i l l be made a v a i l a b l e on t h e fo l lowingschedule :

o t h e first 24 animals a t no charge

o next 24 animals a t 25% normal c o s t ( t h e r e f o r e 48 animals would equal 12.5% o f normal c o s t 1

o next 24 animals a t 50% normal c o s t ( t h e r e f o r e 72 animals would equal 25% o f normal c o s t )

o next 24 animals a t 75%of normal cost ( therefore 96 animals would equal.37.5% of normal c o s t )

o a l l a d d i t i o n a l animals a t 100% normal c o s t

1

o charges w i l l be apport ioned t o animals o f a l l ages requested ( i . e . , f o r a s tudy with 24 t h r e e month o l d and 24 twenty-four month o ld animals, you would be charged f o r 12 animals a t each age . )

Appl ica t ions f o r p i l o t s tudy animals must provide a p ro toca l o f intended r e sea rch i n s u f f i c e n t d e t a i l t o a l low a s c i e n t i f i c peer review o f t h e proposed s tudy . It is most important t h a t t h e re levance o f t h e proposed s tudy t o aging be addressed and t h a t a l i s t i n g o f t o t a l animal needs f o r t h e s tudy be given. Any animals reques ted beyond those l i s t e d i n t h i s a p p l i c a t i o n w i l l be a t f u l l c o s t . N I A w i l l no t provide p i l o t s tudy support t o an i n v e s t i g a t o r more than twice i n a f i v e year per iod .

Animals f o r d i s s e r t a t i o n r e sea rch support w i l l remain free; however, a l e t t e r o f c e r t i f i c a t i o n from t h e appropr i a t e department chairman, s t a t i n g t h a t t h e s tudy f o r which animals are reques ted is an approved d i s s e r t a t i o n s tudy, must accompany each a p p l i c a t i o n .

Appl icants f o r e i t h e r program should al low 90-120 days f o r t h e review process . For f u r t h e r information o r t o r ece ive a p p l i c a t i o n forms f o r e i t h e r of t h e s e programs, con tac t :

Mrs. Jane Soban o r D r D e W i t t G . Hazzard Office o f B io log ica l Resources and Resource DevelopmentNational I n s t i t u t e on AgingBui ld ing 31, Room 5C19 9000 Rockvi l le Pike Bethesda, Maryland 20892

DATED ANNOUNCEMENTS (RFPs AND RFAs AVAILABLE)

CANCER COMMUNICATIONS SYSTEM RESEARCH (CCSR)

RFA AVAILABLE: 86-CA-19

P.T. 34; K.W. 1004017, 1004008, 0403004, 0404021

Nat iona l Cancer I n s t i t u t e

*11Appl ica t ion Receipt Date: January 5, 1987

Letter o f I n t e n t Receipt Date: November 3, 1986

The Div is ion o f Cancer Prevent ion and Control (DCPC) i n v i t e s a p p l i c a t i o n s f o r s t u d i e s t o i n i t i a t e cancer communications r e sea rch a c t i v i t i e s .

This p r o j e c t proposes t o enable q u a l i f i e d i n v e s t i g a t o r s t o i d e n t i f y a cancer communications i s s u e o r problem and develop, implement and eva lua te a r e sea rch p r o j e c t t o address t h e i d e n t i f i e d i s s u e o r problem. The p r o j e c t should be t a r g e t e d a t s p e c i f i c audiences and may u t i l i z e t h e resources o f t h e Cancer Communications System.

BACKGROUND INFORMATION

Since 1976, t h e Cancer Communications System (CCS) (formerly known as t h e Cancer Communications Network) has been funded by t h e Nat ional Cancer I n s t i t u t e ( N C I ) to provide accura te , up t o d a t e information about cancer t o t h e genera l publ ic , cancer p a t i e n t s and t h e i r families and h e a l t h p r o f e s s i o n a l s . This information has been disseminated through t h e Cancer Information Serv ice (CIS), a te lephone information s e r v i c e , and through educa t iona l and informat iona l a c t i v i t i e s c a r r i e d out i n s p e c i f i c geographic areas o f s e r v i c e . Over t h e years , t h e CCS has been e s t a b l i s h e d as a resource , both r e g i o n a l l y and t o t h e N C I . I nd iv idua l s who are t r a i n e d and experienced i n cancer communications s ta f f t h e r eg iona l o f f i c e s o f t h e program. The e x p e r t i s e c u r r e n t l y e x i s t s i n t h e s e o f f i c e s t o market and promote cancer information t o t h e genera l pub l i c as w e l l as s p e c i f i c t a r g e t groups.

The CIS is a c c e s s i b l e t o t h e p u b l i c through a s i n g l e , t o l l free te lephone number (1-800-4-CANCER). Data on each inqu i ry are c o l l e c t e d on a common r e p o r t i n g form. Information i s c o l l e c t e d on t h e type o f u se r , t h e cancer s i t e and sub jec t o f i nqu i ry , t h e behaviora l sugges t ions made by CIS staff, t h e method through which t h e user found o u t about CIS, and s e v e r a l demographic v a r i a b l e s , inc luding sex, age,e t h n i c i t y , and educat ion of t h e u s e r . Co l l ec t ion o f t h i s i n formation has l e d t o a large d a t a base t o use as a research resource . The c e n t r a l i z e d r e p o r t i n g form was

F P

2

i n s t i t u t e d i n January, 1983. Over one m i l l i o n i n q u i r i e s have been handled by t h e CIS n a t i o n a l l y s i n c e t h a t t i m e . These d a t a are c o l l e c t e d r e g i o n a l l y and r epor t ed t o N C I on a semiannual b a s i s .

I n add i t ion , a survey of more than 7,000 Cancer Information Se rv ice u s e r s has been completed. This survey provides information on t h e h e a l t h behavior o f CIS u s e r s as w e l l as t h e i r pe rcep t ions o f t h e program. Information from t h e use r survey can be

@l inked t o t h e o r i g i n a l c a l l record form used dur ing t h e i r i n t e r a c t i o n wi th CIS s ta f f .

The CCS c u r r e n t l y c o n s i s t s o f 16 N C I funded r eg iona l o f f i c e s . An a d d i t i o n a l seven o f f i c e s o p e r a t e CIS programs wi th independent funding. One o f t h e programo b j e c t i v e s o f t h e CCS is t o "serve as a resource f o r t h e development and/orimplementation o f pee r reviewed s t u d i e s f o r cancer communications research , i n coopera t ion wi th t h e g ran tees funded through t h e program e n t i t l e d Cancer Communications System Research."

Limited r e sea rch has been done i n t h e area o f cancer communications. The e x t e n t t o which cancer communications can affect t h e knowledge, a t t i t u d e s and p r a c t i c e s of i n d i v i d u a l s and s t r a t e g i e s t o reach p a r t i c u l a r t a r g e t audiences are areas which a l low f o r much f u r t h e r i n v e s t i g a t i o n . Using t h e resources a v a i l a b l e through t h e Cancer Communications System, it w i l l be p o s s i b l e f o r i n v e s t i g a t o r s t o i n i t i a t e r e sea rch t h a t can meet measurable o b j e c t i v e s .

The purpose o f t h i s announcement is t o support a range cf s t u d i e s f o r r e sea rch t o determine t h e most e f f e c t i v e ways o f communicating about cancer , wi th t h e i n t e n t t h a t t h e r e s u l t s o f t h e s e s t u d i e s w i l l be d i s t r i b u t e d widely through gene ra l and scient i f i c p u b l i c a t i o n s .

GOALS AND SCOPE

The goa l is t o i d e n t i f y a cancer communications i s s u e or problem and development,implement and e v a l u a t e a r e sea rch p r o j e c t t o address t h e i d e n t i f i e d i s s u e or problem. The p r o j e c t should be t a r g e t e d a t s p e c i f i c audiences and may u t i l i z e t h e r e sources o f t h e Cancer Communications System. These r e sea rch p r o j e c t s are no t intended t o eva lua te or enhance t h e CCS program, but t o use it as a r e sea rch resource .

These research p r o j e c t s s h a l l inc lude innovat ive ways t o reach s p e c i f i c t a r g e t groups wi th cancer information and an assessment o f i t s impact on t h e i r knowledge,af i t t i t u d e s and/or p r a c t i c e s . Research should have t h e long term o b j e c t i v e o f c o n t r i b u t i n g t o t h e N C I goa l o f reducing cancer m o r t a l i t y rates by 50% by t h e year2000. P r o j e c t s c o n t r i b u t i n g t o t h i s goal may address cancer prevent ion , e a r l yde tec t ion , t r e a t ment, cont inuing care, or a combination o f t h e s e .

PROJECT DESCRIPTION

I n v e s t i g a t o r s may propose cancer communications r e sea rch p r o j e c t s which u t i l i z e t h e r e sources of t h e Cancer Communications System (e .g . , Cancer Information Se rv ice d a t a , staff e x p e r t i s e , o t h e r educational/informational a c t i v i t i e s ) . P r o j e c t s no t u t i l i z i n g CCS re sources may a l s o be considered responsive t o t h i s RFA.

I n v e s t i g a t o r s may propose new d a t a c o l l e c t i o n a c t i v i t i e s and/or des ign s t u d i e s comparing p u b l i c knowledge, a t t i t u d e s andlor p r a c t i c e s by l o c a t i o n , e t h n i c i t y , age,e tc . A s p e c i f i c group such as women, smokers, b lacks , or people over age f i f t y maybe chosen f o r s tudy . U t i l i z a t i o n o f CCS resources may involve a s i n g l e o f f i c e , a r eg ion o f t h e country, or t h e e n t i r e CCS.

P r o j e c t s may be proposed f o r du ra t ions o f 18 t o 36 months i n l eng th . Shared r e sources on t h e p a r t o f t h e appl icant , such as c o n t r i b u t i o n o f s ta f f time, should be descr ibed i n t h e a p p l i c a t i o n . Some examples o f CCSR p r o j e c t s might inc lude , bu t are no t l i m i t e d t o , t h e fo l lowing (no t i n p r i o r i t y o r d e r ) :

o S t u d i e s on t h e impact o f p u b l i c information campaigns on p u b l i c knowledge,a t t i t u d e s , and/or p r a c t i c e s .

o Research on cancer information seeking behavior by t h e p u b l i c .

o For cancer p a t i e n t s and t h e i r families, r e sea rch i n areas such as de lay i n seeking medical care or compliance with t rea tment regimens.

o Studies on t h e d i f f u s i o n of cancer information.

c o Al te rna te communications s t r a t eg ie s / t echno log ie s and t h e i r e f f e c t on cancerI-, knowledge, a t t i t u d e s , and/or p r a c t i c e s .

3

o S t u d i e s on t h e use and effects o f vo lun tee r s as community opinion l e a d e r s .

o S t u d i e s on t h e effect o f follow-up reminders on t h e h e a l t h a c t i o n i n pub l i c .

o C o s t l b e n e f i t a n a l y s i s o f te lephone information t r a n s f e r .

The conceptual development, s tudy design, methodology, d a t a c o l l e c t i o n instrument ,a n a l y s i s p l ans , and implementation of t h e p r o j e c t is t h e r e s p o n s i b i l i t y of t h e a p p l i c a n t . However, CCS s ta f f may be p r o j e c t i n v e s t i g a t o r s o r c o i n v e s t i g a t o r s , and may be involved i n p repa ra t ion o f t h e g ran t a p p l i c a t i o n .

MECHANISM OF SUPPORT

App l i ca t ions w i l l be funded as r e sea rch g r a n t s . The t o t a l p r o j e c t per iod f o r a p p l i c a t i o n s submit ted i n response t o t h e p re sen t RFA should no t exceed t h r e e yea r s .The i n t e n t is t o fund s e v e r a l p r o j e c t s , with t o t a l c o s t s f o r a l l p r o j e c t s amounting t o approximately $400,000 f o r t h e f irst year .

INQUIRIES

Copies o f t h e complete RFA and a d d i t i o n a l

J u d i t h S t e i n , M.A. Health Promotion Sc iences Branch Divis ion o f Cancer Prevent ion and Control Nat iona l Cancer I n s t i t u t e Blair Bui lding, Room 416 9000 Rockvi l le Pike Bethesda, MD 20892 4200 Telephone: (301) 427 8656

information may be obta ined from:

DEVELOPMENTAL GRANTS FOR ALCOHOLISM TREATMENT ASSESSMENT RESEARCH

P.T. 34; K.W. 0404003, 0415000, 0745060, 0414020, 0730025

Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism

Appl ica t ion Receipt Datesr February 1, 1987, June 1, 1987,October 1, 1987

BACKGROUND

The Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism (NIAAA) i n v i t e s a p p l i c a t i o n sf o r developmental g r a n t s f o r a lcohol ism t rea tment assessment r e sea rch . Developmental g r a n t s ( R 2 1 ) are intended t o genera te s t u d i e s t h a t w i l l be b u i l d i n gblocks i n t h e development of f u t u r e , more i n t e n s i v e and l a r g e r r e sea rch s t u d i e s on alcohol ism t r ea tmen t . Developmental g r a n t s supported under t h i s announcement w i l l be l i m i t e d t o a one-year e f f o r t and a maximum of $30,000 d i r e c t c o s t s .

RESEARCH GOALS

The purpose of developmental g r a n t s is ( 1 ) to support promising a c t i v i t i e s o f i n s t i t u t i o n s t h a t wish t o b u i l d a capac i ty t o do alcoholism t rea tment assessment research; (2) t a conduct p i l o t s t u d i e s l ead ing t o expansion, enhancement, o r modi f ica t ion o f e x i s t i n g alcohol ism t rea tment r e sea rch programs; and ( 3 ) t o p lan and conduct p i l o t r e sea rch l ead ing t o t h e development o f c l i n i c a l t r i a l s i n a lcohol ism treament assessment r e sea rch . I n add i t ion , t h e NIAAA is i n t e r e s t e d i n p r o j e c t swhich focus on s p e c i a l r i s k groups such as women, adolescents and youth, t h e e l d e r l y , and m i n o r i t i e s and e t h n i c groups.

Developmental g r a n t a p p l i c a t i o n s , s o l i c i t e d by t h i s announcement, are appropr i a t ef o r address ing one o r more o f t h e fol lowing a s p e c t s o f a lcohol ism t r ea tmen t : ( 1 )c l i e n t c l a s s i f i c a t i o n and/or typology, ( 2 ) t rea tment regimens, ( 3 ) t h e r a p e u t i c process , ( 4 ) t rea tment s e t t i n g s , and (5) t rea tment formats . E labora t ion of t h e s e f i v e c a t e g o r i e s fo l lows .

1 C l i e n t C l a s s i f i c a t i o n and/or Typology. The purpose o f c l a s s i f y i n ga l c o h o l i c s by "type" is t o permit t h e opt imal matching o f c l i e n t t ypes wi th p a r t i c u l a r t rea tment regimens f o r t h e purpose of enhancing t rea tment e f f e c t i v e n e s s . P r o j e c t s are encouraged t h a t will explore optimal , e f f ic ien t , and empi r i ca l ly based alcohol ism t rea tment c l i e n t t ypo log ie s . P r o j e c t s mayfocus on comparisons of a l t e r n a t i v e typologies , o r on t h e development and ref inement o f a s i n g l e , comprehensive typology.

4

2 Treatment Regimens. Appl ica t ions are encouraged which s tudy and d e l i n e a t e t h e opt imal procedures and p ro toco l s t h a t can be followed and measured when d e l i v e r y of a p a r t i c u l a r t rea tment regimen o r p ro toco l is t o be s t u d i e d f o r r e sea rch purposes . Focus can be on one o r more t rea tment regimens a g a i n s tanother , such as comparisons of cogn i t ive behavior therapy , psychodynamicapproaches, behav io ra l condi t ion ing regimens, s o c i a l s k i l l s t r a i n i n g ,s t ress /anxie ty / insomnia management approaches, pharmacotherapeutic p ro toco l s , e tc . Appl icants are encouraged t o explore those outcome ins t ruments most appropr i a t e f o r a s s e s s i n g a p a r t i c u l a r t rea tment regimen. S t u d i e s are a l s o encouraged which a i m a t enhancing cross-s tudy comparisons o f d i f f e r e n t t rea tment regimens. Appl ica t ions are sought t o ( 1 ) o p e r a t i o n a l i z e and measure t rea tment regimen procedures , ( 2 ) test and compare t h e merits and re levance o f v a r i o u s t r ea tmen t outcome instruments , (3) f o s t e r innovat ive and c o l l a b o r a t i v e r e sea rch i n s tudying d i f f e r e n t i a l t rea tment e f f i c a c y , andlor (4) s t i m u l a t e r e sea rch a s s e s s i n g t h e r e l a t i v e cos t - e f f ec t iveness o f d i f f e r e n t t rea tment regimens f o r d i f f e r e n t c l i e n t t ypes .

3 Therapeut ic Process . S t u d i e s are encouraged which w i l l i d e n t i f y and c l a r i f y t h e r o l e o f t h e t h e r a p e u t i c process and i t s effect on t rea tment outcome and e f f i c a c y . Therapeut ic process can be def ined as a s p e c i a l i z e dhuman r e l a t i o n s h i p t h a t a s k i l l e d t h e r a p i s t develops,. maintains , and manageswi th t h e r a p e u t i c i n t e n t . The goa l is t h e promotion o f l e a r n i n g wi th in an i n t e r p e r s o n a l con tex t . S ince therapy is a process and is un l ike many o t h e r medical procedures o r cu res , it does not e a s i l y lend i t s e l f t o be eva lua ted bytechniques used f o r procedure eva lua t ions . Appl icants may focus on t h e r o l e o f t h e c l i e n t ' s r ead iness and/or motivat ion t o accept t rea tment a t a p a r t i c u l a r t i m e i n t h e course o f h i s ( h e r ) a i lment , and i t s r e l a t i o n s h i p t o i n t e r a c t i o n between c l i e n t l t h e r a p i s t c h a r a c t e r i s t i c s .

4 Treatment S e t t i n g s . Th i s refers t o where t h e t rea tment is de l ive red , and t h e in f luence o f s e t t i n g on t rea tment regimen and t rea tment outcome. Comparisons o f s e t t i n g s might e n t a i l a combination o f s e t t i n g s such as h o s p i t a l i n p a t i e n t , r e s i d e n t i a l , o u t p a t i e n t , educa t iona l , and/or s e l f - h e l po r i e n t a t i o n s . Appl icants may a l s o wish t o s tudy t h e r e l a t i o n s h i p s between t h e s e t t i n g and t h e t rea tment s e rv i ce /de l ive ry system, as w e l l as t h e r e l a t i v e c o s t - e f f e c t i v e n e s s o f d i f f e r e n t t rea tment s e t t i n g s f o r d i f f e r e n t c l i e n t t y p e s .

5 Treatment Formats. P r o j e c t s are encouraged which addres s t h e s p e c i f i cformat i n which t rea tment is de l ive red and t h e in f luence t h a t format may have on c l i e n t outcome. For example, formats may inc lude ind iv idua l counsel ing, group therapy , b r i e f i n t e r v e n t i o n s t r a t e g i e s , o r family/couples approaches.

MECHANISM OF SUPPORT

The suppor t mechanism f o r t h i s program w i l l be t h e developmental r e sea rch g r a n t(R21). These r e sea rch p r o j e c t s are i n v e s t i g a t o r - i n i t i a t e d . Under t h i s mechanism t h e a p p l i c a n t w i l l p lan , d i r e c t , and c a r r y ou t t h e r e sea rch program. Requests f o r developmental g r a n t s should be l i m i t e d t o one year o f support with a maximum o f $30,000 d i r e c t c o s t s pe r a p p l i c a t i o n . It is a n t i c i p a t e d t h a t up t o f i v e g r a n t s can be awarded. It is es t imated t h a t up t o $300,000 w i l l be a v a i l a b l e i n FY 1988 t o support g r a n t s under t h i s announcement.

It is envis ioned t h a t t h e s e g r a n t s may form t h e b a s i s f o r submission of l a r g e r , more i n t e n s i v e , r e g u l a r r e sea rch g r a n t s . Appl icants are encouraged t o cont inue t h e i r p u r s u i t o f a lcohol ism treatment assessment and p a t i e n t placement r e sea rch .

Research g r a n t a p p l i c a t i o n s may be submit ted by p u b l i c o r p r i v a t e non-prof i t o r profi!-making o rgan iza t ions and i n s t i t u t i o n s , S t a t e o r l o c a l governments and t h e i r agencies , and e l i g i b l e agencies o f t h e Federa l Government.

APPLICATION AND REVIEY PROCEDURES

Appl ica t ions i n response t o t h i s s o l i c i t a t i o n w i l l be reviewed f o r s c i en t i f i c and t e c h n i c a l merit by an appropr i a t e peer review group. They w i l l be judged on t h e o v e r a l l s c i e n t i f i c m e r i t o f t h e proposed research , p o t e n t i a l s i g n i f i c a n c e of t h e r e sea rch f ind ings , adequacy o f methodology, and t h e q u a l i f i c a t i o n s o f t h e r e sea rch team.

A secondary review f o r p o l i c y and program re levance w i l l be made by t h e Nat iona l Advisory Council on Alcohol Abuse and Alcoholism. Appl ica t ions w i l l be acceptedonly f o r t h e fo l lowing da te s r February 1, 1987; June 1, 1987; and October I , 1987.

5

The program announcement may be obtained from:

Nat iona l Clearinghouse f o r Alcohol Information Reference Department Box 2345 Rockvil le , Maryland 20852 Telephone: (301) 468-2600 6" Appl ica t ions must be submit ted on form PHS 398 ( r ev i sed 5/82), which is a v a i l a b l e i n \.. t h e bus iness o r g r a n t s and c o n t r a c t s o f f i c e a t most academic and r e sea rch i n s t i t u t i o n s o r from t h e Clearinghouse f o r Alcohol Information. S t a t e and l o c a l government agencies should use form PHS 5161 ( r ev i sed 3/86).

The s igned o r i g i n a l and s i x cop ie s (two copies i f us ing PHS 5161) o f t h e a p p l i c a t i o n should be s e n t t o r

Appl ica t ion Receipt Office Div i s ion o f Research Grants Nat iona l I n s t i t u t e s o f Heal th Westwood Bui ld ing - Room 240 Bethesda, Maryland 20892

More d e t a i l e d information about a p p l i c a t i o n procedures may be obtained fromi

Dan J. Let t i e r i , Ph.D. Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism 5600 F i s h e r s Lane, Room 14-C-20 Rockvi l le , Maryland 20857 Telephone: (301) 443-4223

O N G O I N G PROGRAM ANNOUNCEMENTS

POSTDOCTORAL TRAINING FOR R N s WITH AN EARNED DOCTORATE

P.T. 44; K.W. 0710030, 0730065, 0745035, 0745055, 0783010

Nat iona l Center f o r Nursing Research

The Nat ional Center f o r Nursing Research (NCNR) i n v i t e s a p p l i c a t i o n s f o r c pos tdoc to ra l r e sea rch t r a i n i n g under t h e Nat ional Research Serv ice Award (NRSA).I n d i v i d u a l s wi th an RN who hold an earned doc to ra t e may apply f o r up t o t h r e e yea r s f u l l t i m e r e sea rch t r a i n i n g i n areas o f i n t e r e s t t o t h e NCNR which include--research on t h e c a r e o f p a t i e n t s , t h e promotion o f h e a l t h , t h e prevent ion o f d i sease , and m i t i g a t i o n of t h e effects of acu te and chronic i l l n e s s e s and d i s a b i l i t i e s . I n suppor t o f s t u d i e s of nurs ing in t e rven t ions , procedures, d e l i v e r y methods and e t h i c s o f p a t i e n t ca re , NCNR programs are expected t o complement o the r biomedical r e sea rch programs which are concerned p r imar i ly with causes and t rea tment o f d i sease .

Pos tdoc to ra l exper iences i n conjunct ion with ongoing Research and Demonstration Centers , C l i n i c a l T r i a l s and I n s t i t u t i o n a l Tra in ing Grant programs supported byo t h e r NIH i n s t i t u t e s are of p a r t i c u l a r i n t e r e s t t o t h e NCNR. Requests f o r information about ongoing programs should be addressed t o t h e c a t e g o r i c a l i n s t i t u t e person r e spons ib l e f o r extramural programs l i s t e d below.

D r . Barney LepovetskyChief , Cancer T ra in ing Branch National Cancer I n s t i t u t e Blai rBui ld ing , Room 424B Telephone: ( 3 0 1 ) 427-8898

D r . Henry Roscoe Acting Direc torDivis ion Extramural Affairs Nat iona l Lung, and Blood I n s t i t u t e Westwood Building, Room 7A17A Telephone: ( 3 0 1 ) 496-7225

D r . Thomas ValegaSpec ia l A s s i s t a n t f o r Manpower DevelopmentNat iona l I n s t i t u t e o f Dental Research Westwood Building, Room 507 Telephone: ( 3 0 1 ) 496-6324

6

D r . Walter S t o l z D i r e c t o r , D iv i s ion o f Extramural A c t i v i t i e s National I n s t i t u t e o f Diabetes & Diges t ive &

Kidney Disesases Westwood Building, Room 657 Telephone: ( 3 0 1 ) 496-7277c.Yw D r . Donald Luecke Deputy Di rec to r , Extramural A c t i v i t i e s ProgramNational I n s t i t u t e o f Neurological and

Communicative Disorders and S t roke Fede ra l Bui lding, Room 1016 Telephone: (301) 496-4188

D r . W i l l i a m Bennett Chief , Research Manpower Development S t a f f National I n s t i t u t e o f A l l e r g y & I n f e c t i o u s Diseases Westwood Building, Room 7A03 Telephone: (301) 496-5030

D r . Richard LymnMuscle Biology Program D i r e c t o r National I n s t i t u t e o f A r t h r i t i s

84 Skin Diseases Westwood Building, Room 403 Telephone: (301) 496-7495

D r . John Norvel l Research Tra in ing Officer National I n s t i t u t e of General Medical

& Muscuioskeletal

Sciences Westwood Building, Room 925 Telephone: (301) 496-7260

Ms. Hildegard TopperS p e c i a l A s s i s t a n t t o D i r e c t o r National I n s t i t u t e o f Chi ld Heal th & Human

DevelopmentBuilding 31, Room 2A03 Telephone: ( 3 0 1 ) 496-3454

A?=+

D r . P e t e r DudleyTra in ing Direct o r National Eve I n s t i t u t e Building 37, Room 6A51 Telephone: (301) 496-5983

D r . Chris topher Schonwalder Program D i r e c t o r , Centers and ManpowerNational I n s t i t u t e o f Environmental Heal th Sciences P.O. Box 12233 Research Tr i ang le Park, NC 27709 Telephone: (919) 541-7634

D r . Alan Pinkerson Acting Assoc ia t e D i r e c t o r f o r Extramural A f f a i r s National I n s t i t u t e on AgingBuilding 31, Room 5C06 Telephone: ( 3 0 1 ) 496-9322

D r . Roger Dahlen Chief, Biomedical Informat ion Sirpport Branch National L ib ra ry o f Medicine Building 38A, Room 5s-522 Telephone: (301) 496-4221

D r . J u d i t h V a i t u k a i t i s Chief , General C l i n i c a l Research Centers ProgramDiv i s ion of Research Resources Building 31, Room 5B51 Telephone: ( 3 0 1 ) 496-6595

7

JMAGING TECHNOLOGY I N ALCOHOL RESEARCH

P.T. 34; K.W. 0706030, 0 4 0 4 0 0 3 , 0785165, 0765020, 0710085, 0775025

Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism

Appl ica t ion Receipt Dates: February 1, June 1, October 1

BACKGROUND

The Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism (NIAAAI i n v i t e s g ran ta p p l i c a t i o n s f o r t h e suppor t o f r e sea rch t h a t u t i l i z e s biomedical imaging technology to addres s ques t ions i n both c l i n i c a l and b a s i c a l coho l research . I n t h e las t s e v e r a l y e a r s r a p i d progress has been made i n t h e development and ref inement of imaging and spec t roscop ic techniques , such as computed tomography (CT), magnetic resonance imaging ( M R I ) , i n vivo nuc lear magnetic resonance (NMR) spectroscopy,p o s i t r o n emission tomography (PET), s i n g l e photon emission computed tomography(SPECT), and ul t rasonography, which can probe t h e anatomic, func t iona l ,phys io log ica l , and metabol ic s t a t u s o f n e a r l y any t i s s u e . The p o t e n t i a l b e n e f i t s of us ing t h e s e techniques f o r understanding and diagnosing alcohol ism and its a s s o c i a t e d pa tho log ie s are s i g n i f i c a n t .

RESEARCH GOALS

Grant a p p l i c a t i o n s are s o l i c i t e d f o r p r o j e c t s which w i l l u se imaging moda l i t i e s t o i n c r e a s e t h e e x t e n t and depth o f knowledge on organ processes a f f e c t e d by exposure t o a l coho l and on alcohol-der ived dysfunct ions . The major emphasis is on ga in ing new knowledge t h a t can be app l i ed t o d i agnos i s , t rea tment , and prevent ion o f a lcohol ism. S t u d i e s proposed i n response t o t h i s announcement may encompass a broad range o f d i s c i p l i n e s , inc luding b iophys ics and biochemistry a t t h e molecular,c e l l u l a r , t i s s u e , organ, and whole body l e v e l s ; h i s topa thology; and animal and/orhuman physiology and pathology. C l i n i c a l r e sea rch u t i l i z i n g a l c o h o l i c p a t i e n t s and v o l u n t e e r s is encouraged. Spec ia l areas o f i n t e r e s t are i d e n t i f i e d below. However,a l l areas o f p e r t i n e n t i n v e s t i g a t i o n u t i l i z i n g one or more imaging methodologieswould be appropr i a t e t o t h i s announcement.

,

S t u d i e s on t h e induct ion , progress ion , o r r e v e r s i b i l i t y o f a lcohol- induced pa tho log ica l cond i t ions such as a l coho l - r e l a t ed organic b r a i n syndrome, l i v e r d i sease ,p a n c r e a t i t i s , and cardiomyopathy.

S t u d i e s on t h e dynamics of a lcoho l metabolism i n l i v i n gorganisms.

S t u d i e s t o determine t h e effects o f a l coho l on r eg iona lblood flow and c a r d i a c func t ion .

Loca l i za t ion and d e l i n e a t i o n o f t i s s u e changes a r i s i n gfrom e thano l i n g e s t i o n and concurrent eva lua t ion of t h e biochemical p r o p e r t i e s o f t h e t i s s u e s .

The development of appropr ia te t r a c e r compounds f o r a p p l i c a t i o n s wi th PET, SPECT, o r NMR t o s tudy t h e sites o f a c t i o n o f e thano l and ethanol-drug i n t e r a c t i o n s .

Determinat ion .of t h e r e l a t i o n s h i p s between neuroanatomical o r neurophys io logica l changes (as measured, f o r example, byCT, evoked p o t e n t i a l s or MRI) and cogn i t ive impairments(measured by neuropsychological tests) a s s o c i a t e d with a l coho l use and abuse and with alcohol-der ived fe ta l i n j u r y .

Determination of t h e c l i n i c a l a p p l i c a t i o n s o f t h e combined biochemical response and imaging c o r r e l a t e s o f t i s s u e s from a l c o h o l i c s and a l coho l abusers .

S t u d i e s t o e v a l u a t e t h e e f f i c a c y of d i f f e r e n t imagingmoda l i t i e s i n t h e d i agnos i s o f s p e c i f i c a l coho l - r e l a t ed d i s o r d e r s .

Assessment o f i n d i v i d u a l s p r e n a t a l l y exposed t o a lcohol f o r p o t e n t i a l organ ( inc lud ing b r a i n ) i n j u r y and t h e r e v e r s i b i l i t y of t h e i n u t e r o i n j u r y .

8

C? MECHANISM OF SUPPORT

The support mechanism f o r t h i s program w i l l be t h e t r a d l t i o n a l i n v e s t i g a t o r - i n i t i a t e d r e sea rch p r o j e c t g r a n t . Under t h i s mechanism t h e a p p l i c a n t w i l l p l an , d i r e c t , and c a r r y out t h e r e sea rch program. Applicants are expected t o have access t o e x i s t i n g imaging instrumentat ion, e i t h e r w i th in t h e i r own i n s t i t u t i o n s o r through c o l l a b o r a t i o n s with i n v e s t i g a t o r s a t o t h e r i n s t i t u t i o n s . The p r o j e c t p e r i o d du r ing which t h e r e s e a r c h w i l l be conducted should adequately re f lec t t h e t i m e r e q u i r e d t o accomplish t h e s t a t e d g o a l s and be c o n s i s t e n t with t h e p o l i c y f o r g r a n t suppor t . Support w i l l be provided f o r up t o f i v e y e a r s (renewable f o r subsequent p e r i o d s ) s u b j e c t t o t h e a v a i l a b i l i t y o f funds and p r o g r e s s achieved.

Research g r a n t a p p l i c a t i o n s may be submitted by nonpro f i t and p ro f it-making o r g a n i z a t i o n s and i n s t i t u t i o n s , S t a t e o r l o c a l governments and t h e i r agencies , and e l i g i b l e agenc ie s o f t h e Federal government.

APPLICATION AND REVIEW PROCEDURES

Appl i ca t ions i n response t o t h i s s o l i c i t a t i o n w i l l be reviewed f o r s c i e n t i f i c and t e c h n i c a l m e r i t by an a p p r o p r i a t e pee r review group. They w i l l be judged on t h e o v e r a l l s c i e n t i f i c m e r i t o f t h e proposed r e sea rch , p o t e n t i a l s i g n i f i c a n c e of t h e r e s e a r c h f i n d i n g s , adequacy o f methodology, a v a i l a b i l i t y o f necessa ry fac i l i t i es , and t h e q u a l i f i c a t i o n s o f t h e r e sea rch team.

Appl i can t s must demonstrate e x p e r t i s e and p r o f i c i e n c y i n t h e use o f one o r more imaging systems. A secondary review f o r p o l i c y and program relevance w i l l be made by t h e Nat ional Advisory Council on Alcohol Abuse and Alcoholism.

Appl i ca t ions w i l l be accepted i n accordance with t h e usua l r e c e i p t d a t e s f o r new a p p l i c a t i o n s :

February 1 June 1 October 1

The program announcement may be obtained from:

National Clearinghouse f o r Alcohol Information Reference DepartmentBox 2345 Rockvil le , Maryland 20852 Telephone: ( 3 0 1 ) 468-2600

Appl i ca t ions must be submitted on form PHS 398 ( r e v i s e d 5 / 8 2 ) , which is a v a i l a b l e i n t h e b u s i n e s s o r g r a n t s and c o n t r a c t s o f f i c e a t most academic and r e s e a r c h i n s t i t u t i o n s o r from t h e Nat ional Clearinghouse f o r Alcohol Information. S t a t e and l o c a l government agenc ie s should use form PHS 5161 ( r e v i s e d 3 / 8 6 ) .

The s igned o r i g i n a l and s i x cop ie s (two cop ie s i f us ing PHS 5 1 6 1 ) o f t h e a p p l i c a t i o n should be s e n t t o :

App l i ca t ion Receipt Office Div i s ion o f Research Grants N a t i o n a l I n s t i t u t e s of Health Westwood Bu i ld ing - Room 240 Bethesda, Maryland 20892

More d e t a i l e d information about a p p l i c a t i o n procedures

Helen M . Chao, Ph.D. Chief, Biomedical Research Branch

o r

Ernes t ine Vanderveen, Ph.D. Chief, C l i n i c a l and Psychosocial Branch National I n s t i t u t e on Alcohol Abuse and Alcoholism 5600 F i s h e r s Lane, Room 14C-17 Rockviller Maryland 20857 Telephoner ( 3 0 1 ) 443-4223

may be ob ta ined from:

9

--

EESEARCH GRANTS ON ALCOHOL AND IMMUNOLOGY INCLUDING ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)

P.T. 34; K.W. 0715120

Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism m w

Appl ica t ion Receipt Dates: Feb 1, June 1, Oct 1

BACKGROUND

The Nat iona l I n s t i t u t e on Alcohol Abuse and Alcoholism ( N I A A A ) makes g ran t awards f o r b a s i c and app l i ed a l coho l r e sea rch p r o j e c t s . N I A A A has a long-standing in te res t i n t h e r e l a t i o n s h i p between a lcohol consumption and immunologic d i s o r d e r s , and it now wants t o inc rease t h e l e v e l o f a c t i v i t y i n t h i s r e sea rch area. Fur ther , t h e emergence of Acquired Immunodeficiency Syndrome (AIDS) z s a s i g n i f i c a n t p u b l i ch e a l t h concern has served t o re-emphasize N I A A A ' s commitment t o r e sea rch on t h e effects o f a l coho l consumption on immunologic func t ion ing and, s p e c i f i c a l l y , t h e r o l e o f a l coho l as a p o t e n t i a l co-factor i n AIDS and HTLV-I11 v i r u s i n f e c t i o n . V i r t u a l l y no information is a v a i l a b l e regard ing t h e use labuse of a l coho l by AIDS p a t i e n t s o r how a l coho l may affect t h e course and/or t rea tment of t h e d i s e a s e p rocess . Th i s s p e c i a l announcement is intended t o encourage t h e submission o f a p p l i c a t i o n s from i n v e s t i g a t o r s t o compete f o r funds t o s tudy t h e r e l a t i o n s h i p of a lcoho l consumption t o immunologic d i s o r d e r s and i n f e c t i o u s d i s e a s e s .

RESEARCH GOALS

The I n s t i t u t e wishes t o expand i ts support f o r r e sea rch on a11 a s p e c t s o f t h e r e l a t i o n between a l coho l and i n f e c t i o u s d i sease . I n v e s t i g a t o r s i n a l l r e l e v a n t f i e l d s are encouraged t o apply, inc luding those i n epidemiology, immunology,bac te r io logy , v i ro logy , pathology, and o t h e r r e l e v a n t c l i n i c a l and b a s i c s c i e n t i f i c d i s c i p l i n e s . The fo l lowing are some broadly def ined areas r e l a t e d t o a l coho l ,immunology, and i n f e c t i o u s d i s e a s e s which are o f i n t e r e s t and i n need of f u r t h e r i n v e s t i g a t i o n :

o Epidemiologic s t u d i e s o f t h e inc idence and prevalence o f t h e va r ious t y p e sof immune d e f i c i e n c i e s and i n f e c t i o u s d i s e a s e s among a lcohol abuse r s and a l c o h o l i c s .

o Basic and a p p l i e d r e sea rch r e l a t e d t o t h e effects of a lcohol use labuse on .I* i n c r e a s i n g r i s k f o r i n f e c t i o n , inc luding l a b o r a t o r y s t u d i e s o f immune func t ion

and s t u d i e s of r e s i s t a n c e t o b a c t e r i a l l v i r a l cha l lenge .

o Rela t ion between t h e ra te and p e r s i s t e n c e o f a lcohol consumption and t h e degree o f immunosuppression. S t u d i e s o f mechanisms by which a l coho l suppresses immune func t ions .

o S t u d i e s on t h e r o l e o f a lcohol uselabuse i n modifying t h e course and t rea tment o f b a c t e r i a l o r v i r a l d i s e a s e af ter i n f e c t i o n . The r e l a t i o n s h i p o f a l c o h o l i c l i v e r d i s e a s e t o t h e incidence o f i n f e c t i o n .

o The effects of a l coho l on e x i s t i n g i m m u n e f unc t ion i n immunodeficiencyd i s e a s e s ta tes .

o The r o l e o f n u t r i t i o n a l de f i c i ency which may i n t e r a c t a long wi th t h e consumption o f a l coho l i n t h e suppress ion of immune func t ions .

More s p e c i f i c areas o f i n t e r e s t r e l a t e d t o AIDS are l i s t e d below:

0 Epidemiologic s t u d i e s of dr ink ing p r a c t i c e s o f AIDS and AIDS-related complex(ARC) p a t i e n t s , o f persons t e s t i n g p o s i t i v e f o r HTLV-111 ant ibody, and of persons i n h igh r i s k groups f o r i n f e c t i o n .

0 Incidence and prevalence s t u d i e s of HTLV-I11 p o s i t i v e , ARC and AIDS amonga l c o h o l i c s and a l coho l abusers , e s p e c i a l l y t h o s e who are no t in t ravenous drugabusers .

0 The r o l e o f a lcohol consumption i n i nc reas ing r i sk - t ak ing behavior ( e .g . ,d i s i n h i b i t i o n ) which may enhance t h e p r o b a b i l i t y o f HTLV-I11 i n f e c t i o n by exposure, f o r example, t o o t h e r h igh r i s k sexual or drug abuse behaviors .

0 S t u d i e s us ing animal models t o determine t h e p o t e n t i a l r o l e o f a l coho l as a co - fac to r f o r HTLV-I11 i n f e c t i o n and/or t h e development o f AIDS.

y r l 0 Mechanisms o f a lcohol e f f e c t s on c e l l mediated immunity and t h e r e l a t i o n s h i p t o a c q u i s i t i o n o f HTLV-I11 and r e l a t e d v i r u s e s .

10

o S t u d i e s o f t h e d i f f e r e n t i a l immunosuppressive effects of a c u t e i n t o x i c a t i o n as opposed t o t h e ch ron ic consumption o f a l coho l .

MECHANISM OF SUPPORTc>Th e support mechanism f o r t h i s program w i l l be t h e t r a d i t i o n a l

i n v e s t i g a t o r - i n i t i a t e d r e sea rch p r o j e c t g r a n t . The p r o j e c t pe r iod du r ing which t h e r e sea rch w i l l be conducted should adequately re f lec t t h e t i m e r e q u i r e d t o accomplisht h e s t a t e d g o a l s and be c o n s i s t e n t with t h e p o l i c y f o r g r a n t suppor t . Support w i l l be provided f o r up t o f i v e yea r s (renewable f o r subsequent p e r i o d s ) s u b j e c t t o t h e a v a i l a b i l i t y of funds and p rogres s achieved.

Research g r a n t a p p l i c a t i o n s may be submit ted by nonpro f i t o r g a n i z a t i o n s and i n s t i t u t i o n s , S t a t e o r l o c a l governments and t h e i r agencies , f o r p r o f i t organ iza t ions , and e l i g i b l e agencies o f t h e Federal government.

APPLICATION AND REVIEW PROCEDURES

Appl i ca t ions i n response t o t h i s s o l i c i t a t i o n w i l l be reviewed f o r s c i e n t i f i c and t e c h n i c a l m e r i t by an a p p r o p r i a t e peer review group. A secondary review f o r p o l i c y and program re l evance w i l l be made by t h e a p p r o p r i a t e Nat ional Advisory Council .

Appl i ca t ions w i l l be accepted i n accordance with t h e usual r e c e i p t d a t e s f o r new a p p l i c a t i o n s :

February 1 June 1 October 1

The s p e c i a l announcement may be obtained from:

Nat iona l Clearinghouse f o r Alcohol Information Reference DepartmentBox 2345 Rockvil le , Maryland 20852 Telephone: (301) 468-2600

Appl i ca t ions must be submitted on form PHS 398 ( r e v i s e d 5/82), which is a v a i l a b l e i n t h e bus iness o r g r a n t s and c o n t r a c t s o f f i c e a t most academic and r e s e a r c h

GHi n s t i t u t i o n s o r from t h e Nat ional Clearinghouse f o r Alcohol Information. S t a t e and l o c a l government agenc ie s should u s e form PHS 5161 ( r e v i s e d 3/86).

The s igned o r i g i n a l and s i x cop ie s (two cop ie s i f us ing form PHS 5161) o f t h e a p p l i c a t i o n should be s e n t t o :

Appl i ca t ion Receipt O f f ice Div i s ion o f Research Grants National I n s t i t u t e s o f Heal th Westwood Building - Room 240 Bethesda, Maryland 20892

More d e t a i l e d information about a p p l i c a t i o n procedures can be ob ta ined from:

Helen M. Chao, Ph.D. Chief, B iomed ica l Research Branch

E r n e s t i n e Vanderveen, Ph.D. Chief, C l i n i c a l and Psychosocial Research Branch Div i s ion o f Extramural Research National I n s t i t u t e on Alcohol Abuse and Alcoholism 5600 F i s h e r s Lane, Room 14C-17 Rockvil le , Maryland 20857 Telephone: (301) 443-4223

or

GENETIC ASPECTS OF SPEECH, LANGUAGE AND READING DISORDERS

P.T. 34; K.W. 0710120r 1002019, 0715055, 0715090, 0755030, 0404004

National I n s t i t u t e o f Neurological and Communicative Disorders and S t roke

National I n s t i t u t e o f Chi ld Heal th and Human Development

The National I n s t i t u t e of Neurological and Communicative Disorders and S t roke (NINCDS) and t h e Nat ional I n s t i t u t e o f Child Health and Human Development ( N I C H D ) encourage t h e submission o f r e sea rch p r o j e c t g r a n t a p p l i c a t i o n s ( R o l l t o i n v e s t i g a t e g e n e t i c a s p e c t s of primary speech and language d i s o r d e r s aimed a t determining t h e f a c t o r s c o n t r i b u t i n g t o t h e e t i o l o g i e s o f t h e s e d i s o r d e r s .

1 1

I. BACKGROUND

Frequent c l i n i c a l r e p o r t s are publ ished o f twins with s imilar d i s o r d e r s and o f families wi th a h igh propor t ion of members over several gene ra t ions with s imilar o r r e l a t e d speech and language d i s o r d e r s such as s t u t t e r i n g and delayed languagedevelopment. Recent ly t h i s l i t e r a t u r e has a l s o included r e p o r t s o f geneticmechanisms be ing l i n k e d t o dys l ex ia . Fur ther , p r o f i l e s o f speech and languageimpairment are c o n s i s t e n t a c r o s s p a t i e n t s with t h e same g e n e t i c abnormali ty (e .g . ,47 XXY males evidence one p r o f i l e while 47 XXX females e x h i b i t a d i f f e r e n t speechand language p r o f i l e ) . Few i n v e s t i g a t i o n s have focused on p o s s i b l e g e n e t i c f a c t o r s i n congen i t a l speech and language d i s o r d e r s . D i f f i c u l t i e s may have been t h e l a c k of clear o b j e c t i v e c r i t e r i a f o r de f in ing t h e c h a r a c t e r i s t i c s o f t h e communicative d i s o r d e r ( e . g . s t u t t e r i n g , speech a r t i c u l a t i o n d i s o r d e r o r developmental languaged i s o r d e r s ) and a l a c k o f sha r ing o f e x p e r t i s e and c l o s e c o l l a b o r a t i o n between i n v e s t i g a t o r s i n behaviora l g e n e t i c s and speech and language d i s o r d e r s . In 1983,t h e NINCDS sponsored t h e p u b l i c a t i o n o f t h e proceedings o f a working group o f s c i e n t i s t s aimed a t encouraging i n v e s t i g a t i o n s i n t h i s area. I n 1985, t h e NICHD sponsored a conference on b iobehaviora l measures o f dys l ex ia . (Genetic Aspects o f Speech and Language Disorders . Ludlow, CL and Cooper, J A (Eds) Academic P r e s s ,1985; Biobehavioral Measures o f Dyslexia . Gray, DB, and Kavanagh, J F (Eds) York P r e s s 1985.) The NICHD cont inues t o support s t u d i e s o f t h e g e n e t i c bases o f d y s l e x i a .

The purpose o f t h i s announcement is t o encourage a p p l i c a t i o n s t o i n v e s t i g a t e t h e p o s s i b l e c o n t r i b u t i o n s o f g e n e t i c f a c t o r s t o t h e d i s o r d e r s of s t u t t e r i n g , speecha r t i c u l a t i o n d i s o r d e r s , dys l ex ia , and c h i l d r e n ' s developmental language d i s o r d e r s .

11. RESEARCH GOALS AND SCOPE

The NINCDS encourages both b a s i c and c l i n i c a l i n v e s t i g a t i o n s i n t o t h e p o s s i b l e e t i o l o g y and pa thogenes is o f chronic and p e r s i s t e n t s t u t t e r i n g and severe developmental childhood speech a r t i c u l a t i o n and/or language d i s o r d e r s . I n v e s t i g a t o r s are encouraged t o develop c o l l a b o r a t i o n s between those wi th e x p e r t i s e i n g e n e t i c r e sea rch and those wi th e x p e r t i s e i n s t u t t e r i n g , o r primary developmental speechl language d i s o r d e r s . The NICHD encourages both b a s i c and c l i n i c a l l y r e l e v a n t r e sea rch i n t o t h e p o s s i b l e e t i o l o g y o f developmental dys l ex ia . I n v e s t i g a t o r s are encouraged t o e s t a b l i s h c o l l a b o r a t i o n s between those wi th e x p e r t i s e i n g e n e t i c r e sea rch and t h o s e with e x p e r t i s e i n developmental dys l ex ia . The examples g iven below are not l i m i t i n g . /-

1 S t u d i e s o f p a t i e n t s and t h e i r families are encouraged employing comprehensive t and o b j e c t i v e measures o f speech and language behaviors . Pedigree ana lysesand g e n e t i c s t u d i e s us ing modern p r e c i s e methods are needed t o address whether t h e r e is e t i o l o g i c he t e rogene i ty and/or v a r i a t i o n s i n penetrance.

2 Famil ies wi th a h igh prevalence o f s imilar speech, language, phenotypes and reading d i s o r d e r may be cons idered f o r biochemical s t u d i e s aimed a t determining t h e chromosomal l o c a t i o n and l i nkage r e l a t i o n s h i p s o f p o s s i b l e genes a s s o c i a t e d wi th t h e s e d i s o r d e r s .

3 S t u d i e s o f b r a i n development p a t t e r n s a s soc ia t ed wi th t h e s e d i s o r d e r s are encouraged, as awe neuro-imaging s t u d i e s o f p a t i e n t s and t h e i r families wi th a h igh preva lence of similar d i s o r d e r s .

111. MECHANISM OF SUPPORT

Support w i l l be through t r a d i t i o n a l r e sea rch p r o j e c t g ran ts - in-a id .

I V . TERMS AND CONDITIONS OF SUPPORT

Support f o r a p p l i c a t i o n s submit ted i n response t o t h i s announcement w i l l be through g r a n t s f o r i nd iv idua l r e sea rch p r o j e c t s . Grant funds may be used only f o r t h o s e expenses c l e a r l y r e l a t e d t o and necessary t o c a r r y out research p r o j e c t s , and must be expended i n conformance with t h e Publ ic Heal th Serv ice Grants Po l i cy Statement . I n genera l , g r a n t funds may be used f o r : ( 1 ) d i r e c t c o s t s which are necessary t o c a r r y ou t t h e p r o j e c t , inc luding s a l a r i e s , consu l t an t fees, supp l i e s and equipment,and e s s e n t i a l t r a v e l ; (2) a c t u a l i n d i r e c t c o s t s t o cover r e l a t e d overhead. No funds have been set a s i d e f o r funding a p p l i c a t i o n s submit ted i n response t o t h i s announcement.

12

---

V. METHOD OF APPLYING

Applicants should u s e t h e s t anda rd PHS-398 ( r e v i s e d 5/82) r e s e a r c h g r a n t a p p l i c a t i o nform. I n v e s t i g a t o r s concerned wi th t h e g e n e t i c a s p e c t s of s t u t t e r i n g , a r t i c u l a t i o n d i s o r d e r s and developmental language d i s o r d e r s should t y p e "NINCDS/GENETIC ASPECTS

\, OF SPEECH AND LANGUAGE" i n i t e m #2 on t h e face page o f t h e a p p l i c a t i o n .fqwj I n v e s t i g a t o r s concerned with t h e g e n e t i c a s p e c t s of d y s l e x i a should t y p e"NICHD/GENETIC ASPECTS OF DYSLEXIA" i n i t e m #2 on t h e face page of t h e a p p l i c a t i o n .

App l i ca t ions i n response t o t h i s announcement w i l l be reviewed according t o t h e usua l schedule:

Recei pt of I n i t i a l Advisory Council Ear l ies t App l i ca t ions Review Review Award Date

October 1 February May J u l y 1 February 1 June September-October December 1 June 1 October January-February A p r i l 1

The o r i g i n a l and 6 c o p i e s of t h e a p p l i c a t i o n must be s e n t d i r e c t l y t o :

App l i ca t ion R e c e i p t Office Div i s ion o f Research Grants Nat ional I n s t i t u t e s of Health 5333 Westbard Avenue Bethesda, MD 20892

V. REVIEW PROCEDURES

App l i ca t ions w i l l be reviewed f o r s c i e n t i f i c merit and r e l evance t o program g o a l s i n accordance with t h e s t anda rd review procedures o f t h e Pub l i c Heal th S e r v i c e ; t h a t is, each a p p l i c a t i o n w i l l be a s ses sed first for s c i e n t i f i c merit by an a p p r o p r i a t eI n i t i a l Review Group ( I R G ) of non-Government s c i e n t i s t s and t h e n f o r p o l i c y and program re l evance by t h e a p p r o p r i a t e Nat ional Advisory Council .

V I . STAFF CONSULTATION

For f u r t h e r information, p o t e n t i a l a p p l i c a n t s i n t e r e s t e d i n s t u t t e r i n g , a r t i c u l a t i o n . d i s o r d e r s or c h i l d r e n ' s developmental language d i s o r d e r s may cal l o r write t o :

(w;? C h r i s t y L. Ludlow, Ph.D. Communicative Di so rde r s ProgramNational I n s t i t u t e o f Neurological and Communicative

Disorders and S t roke 7550 Wisconsin Avenue Federal Bui lding, Room 1C-06 Bethesda, Maryland 20892 (301) 496-5061

For f u r t h e r information, p o t e n t i a l a p p l i c a n t s i n t e r e s t e d i n d y s l e x i a may ca l l or w r i t e t o :

Norman A. Krasnegor, Ph.D. Chief, Human Learning and Behavior Branch Nat ional I n s t i t u t e o f Chi ld Heal th and Human DevelopmentLandow Building Rm. 7C-18 7910 Woodmont Avenue Bethesda, MD 20892 (3011 496-6591

These programs are desc r ibed i n t h e Catalog o f Federal Domestic Ass i s t ance , No. 13.853, National I n s t i t u t e o f Neurological and Communicative Disorders and S t roke and No. 13.865, National I n s t i t u t e o f Child Health and Human Development. Grants w i l l be awarded under t h e a u t h o r i t y o f Pub l i c Heal th S e r v i c e A c t , T i t l e IV, S e c t i o n 301 (Pub l i c Law 78-410, as amended; 42 U.S.C. 214) and adminis tered under PHS g r a n tP o l i c i e s and Federal Regulat ions 42 CFR P a r t 52 and 45 CFR P a r t 74. This program is no t s u b j e c t t o t h e intergovernmental review requirements o f Executive Order 12372 o r Heal th Systems Agency Review.

+U.S. GOVERNMENT P R I N T I N G OFFICE:1986-~91-284~40014 13