National Institute on Aging

Judith A. Salerno, M.D., M.S.

Deputy Director

NIA/NIH/DHHS

ADC MeetingApril 2004

National Institute on AgingTrends in AppropriationsFiscal Years 1994 - 2004

0

200

400

600

800

1,000

Fiscal Year

Mil

lio

ns

$ Millions 420.3 433.3 453.5 484.3 517.1 594.6 685.7 785.4 891.3 993.6 1025

94 95 96 97 98 99 2000 2001 2002 2003 2004

3%increase

5%increase

7%increase

7%increase

15%increase

15%increase

15%increase

14%increase

12%increase

3.2%increase

National Institutes of HealthAlzheimer’s Disease Research

Fiscal Years 1990 – 2003

0100200300400500600700

Fiscal Year

Dol

lars

in M

illio

ns

NIA 94 155 197 203 213 215 225 244 260 300 350 399 447 502

Other NIH 52.2 74.4 81.8 84.5 85.3 81.7 79.6 85.3 96.3 106.3 106.5 126.0 148 157

90 91 92 93 94 95 96 97 98 99 00 01 02 03

National Institute on AgingDistribution of Obligations by

Budget Category: Fiscal Year 2003

Training2.3%

SBIR/STTR2.3%

Centers8.5% Research

Project Grants 64.5%

Intramural9.7%

Contracts6.2%

Other3.3%

RM&S3.3%

Total NIA: $993,598,000 FY 2003 appropriations post rescission NIA Budget Sept. 2003

NIA CentersFiscal Year Obligations

0

10

20

30

40

50

60

70

80

90

FY01 FY02 FY03 FY04 est.

AD Centers

Other Centers

Do

llars

in m

illio

ns

6.9% increase5.5% increase

1.5 - 2.0% increase

Alzheimer’s Disease CentersFY 2004 (est.)

41%

59%

Other CentersAD Centers

Total NIA Centers FY 04: $85.4M

Additional Sources of Supportfor Alzheimer’s Disease Centers

National Alzheimer’s Coordinating Center– $3.222 M in FY03 RPG funds– Re-competing in FY 04

NIA Centers Reserve– Additional $1.2 M in FY 03; little or no reserve in FY 04

NIA Director’s Reserve– RFA on Collaborative Studies on AD and Other

Neurodegenerative Diseases Associated with Aging: $1.5M for FY 03

– RFA on the Alzheimer’s Disease Neuroimaging Initiative: NIA will commit $8M (U01) for FY 04; additional support from non-government sources anticipated.

NIA Funding Policy for RPGsFY 2004

NIA has experienced a 38% increase in the number of new and competing applications received from FY 2003 to FY 2004 and a 40% increase in total funds requested by these applications.

At the same time, the FY 2004 NIA extramural budget has increased by approximately $28 million or 2.9%.

NIA Funding Policy for RPGsFY 2004 – Cont’d

To manage its resources, consider program priority areas and to support a full range of excellent research, NIA announces the following funding policy:

– In FY2003, NIA funded 411 competing Research Project Grants (RPGs) at a total cost of $159 million. In FY2004, NIA plans to support a similar number of grants at a total cost of $165 million.

– NIA expects to fund Research Project Grants (R01, P01, U01, R03, R21, R15) to approximately the 15th percentile at this time.

– To reach this pay line, NIA will reduce competing grants by an average of 18% below levels recommended in peer review. 

– Reductions for other non-RPG mechanisms will be negotiated on a case-by-case basis. Further adjustment in the pay line may be made as the fiscal year proceeds.

New Funding Policy for Program Project (PO1) Applications

To continue to fund a diverse research portfolio, new and competing PO1 applications will be limited to no more than $1.5 million in direct costs in first year. Budget increases in non-competing years will be at the standard NIH adjustments.

Policy effective with applications submitted for June 1, 2004 receipt date.

Exceptions to the cap will be rarely allowed and only after approval of NIA-wide Planning Group.

Outlook for FY 2005:

? ? ?

The Roadmap:

Where are we going?

Bench Bedside Practice

Building Blocks PathwaysMolecular LibrariesBioinformatics and Computational BiologyStructural BiologyNanomedicine

TranslationalResearchInitiatives

Clinical ResearchInformatics

Integrated ResearchNetworksClinical outcomes

TrainingNational Clinical Research Associates

Interdisciplinary ResearchPioneer Award Nanomedicine

Public PrivatePartnerships

NIH Roadmap Strategy

Re-engineering the Clinical Research

Enterprise

Public-PrivatePartnerships

High-riskResearch

Interdisciplinary Research Nanomedicine

Bioinformatics and Computational Biology

StructuralBiology

Building Blocks, Biological Pathways

and Networks

Molecular Libraries

and Imaging

ImplementationImplementationGroupsGroups

New Pathways to DiscoveryResearch Teams

ClinicalEnterprise

Key Elements of Roadmap Funding and Management

All Institutes:– Participate with their scientific community in defining all components

of the Roadmap– Contribute equally and proportionately– Participate directly in decision making and have a direct liaison to the

Roadmap

All Roadmap initiatives are offered for competition to researchers from all fields

All research communities can compete for all initiatives

The peer-review process will ensure appropriate expertise

Roadmap Funding (dollars in millions)

New Pathwaysto Discovery

Re-engineering the Clinical Research Enterprise

Research Teamsof the Future

NIH

$64.1

$26.6 $37.6

FY 2004 Funding = $128.3 (dollars in millions)

Roadmap Funding(dollars in millions)

FY04 FY05 FY06 FY07 FY08 FY09 Total

Pathways to

Discovery

64 137 169 182 209 188 948

Research

Teams

27 39 44 92 96 93 390

Clinical

Research

38 61 120 174 214 227 833

Total 128 237 332 448 520 507 2,172

To be competed for in a common pool of initiatives by all researchers from every discipline

0.34% 0.63% ~0.9%

NIH Roadmap Goals

Accelerate basic research discoveries and speed translation of those discoveries into clinical practice

Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people

“How does the NIH Roadmap benefit my research area?”

Speeding removal of major and fundamental roadblocks common to all diseases

No Institute can solve these issues alone

THIS IS A COMMON TRANS-NIH POOL OF TRANSFORMING INVESTMENTS OPEN TO ALL DISEASE AREAS FOR COMPETITION

“Yes, but we’re already doing those things. What’s new?”

THE NIH ROADMAP POOLS RESOURCES FOR SPECIFIC ENABLING INVESTMENTS THAT INDIVIDUAL INSTITUTES COULD NOT UNDERTAKE

Expanding molecular probe libraries publicly available to researchers by a factor of 7

Increasing the number of publicly available molecular probes from less than 100,000 to over 500,000

Developing a common national research informatics platform allowing interoperability for data for all patients whether seen at a research hospital or in their own community (NECTAR)

Improving the implementation of Breakthrough research trials through the creation of INTEGRATED research partnerships

MORE RAPID DIFFUSION OF BEST PRACTICES TO PATIENTS

Keep up-to-date on the Roadmap activities:

www.nihroadmap.nih.gov