Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity...

Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity

by Aasef G. Shaikh, Simon Hong, Ke Liao, Jing Tian, David Solomon, David S. Zee, R. John Leigh, and Lance M. Optican

BrainVolume 133(3):923-940

March 19, 2010

© The Author(s) 2010. Published by Oxford University Press on behalf of Brain.

Schematic representation of the Guillain–Mollaret triangle formed by connections between the deep cerebellar nuclei and contralateral inferior olive, which pass near the red nucleus (A).

Aasef G. Shaikh et al. Brain 2010;133:923-940


Three second epochs from records of binocular recordings from 15 OPT patients.



Power spectra from the same 15 OPT patients (H = horizontal; V = vertical; T = torsional).



Quantitative summary of the dominant frequency of OPT oscillations in each patient.



Schematic showing the principle of ICA. A given set of observed, mixture signals (red oscillations) are presumed to be a linear mixture (central box; hypothetically the vestibular or

deep cerebellar nuclei) of six hidden, independent oscillators (green waveforms).



An example of cycles where the residual signal (black trace), i.e. the difference of the actual signal (cyan trace) and presumed inferior olive spike (red trace) lagged (A) or led (B) the peak of

the inferior olive spike.



The qualitative illustration of 3D oscillations generated by 15 de novo model simulations (same format as Fig. 2; see legend for colors).



Power spectra from the same 15 simulations (format is the same as Fig. 3; see legend for colors).



The effects of progressively reducing the contribution of cerebellar learning or inferior olive coupling on OPT. Top row shows effects of reducing the modulation of the deep cerebellar

nuclei by Purkinje neurons (PC).



Progressively reducing the inferior olive coupling strength (green) or cerebellar modulation (blue) (gain is per cent of full strength) reduces amplitude but not frequency in simulated

oscillations.



Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity...

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