nutrition pharmacologic Clinical and Tehran university of ... · pharmacologic nutrition Kaveh...

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1 ی و روده ای تغذیه ورید کبرگبه سوء تغذیهمی:دکتز اس مدرسClinical and pharmacologic nutrition Kaveh eslami Pharm.D, board certified clinical pharmacy resident Tehran university of medical science Department of pharmacotherapy څ ڋ ثػ اـائڅٱٷىبڀڋ ټ ؛ اڌځٱڅ زڅؿڌڅ اوز٥ؽ، ټ٭ؽټبر س غڃاچؽmalnutrition ڌبundernutrition ؼاـڀؽ،ځڍٻ ڂ اڌځٱڅ اٴف ټڋ ڋ ـا سدڃڌك٠ځڃؿڌڅ ټ٥ىبڀڋ ټب ټڋ ثبڌىز س ثڅ زڅڃـ ثبڌؽؿڌڅ ـا اڀدبٺ ؼچڍٻ ز٥ غڃاچڍٻ اڌٿ سبـ ـا ثٱځڍٻ. اڌٿEffect of nutritional support on clinical outcome in patients at nutritional risk Nutrition care is a vital component of quality patient care Malnutrition can increase length of stay in hospital Patients generally are considered at risk of nutrient depletion and associated increased morbidity and mortality Clinical Nutrition (2004) 23, 539550 طثجز اق ثڍٽبـ ث٬ ڌٱڋ اق اخكاڊ ثىڍبـ ټڇٻ ؼـ ټفاnutrition support ؿڌڅ اڊ اوز؛ ڌٱڋ اق٥جز چبڊ س٬ ڌب ټفاؽپ ؼـ ثڍٽبـوشبپ ؼاـؼ ثط څ ثىڍبـ ڀكؼڌٯ ثب ټؽر ثىشفڊڅ ـاث ټىبئٹڋؿڌڅ ـا٥طث سځڋ اٴف ث١ؿڌڅ اوز. ڌ٥ ث س

Transcript of nutrition pharmacologic Clinical and Tehran university of ... · pharmacologic nutrition Kaveh...

Page 1: nutrition pharmacologic Clinical and Tehran university of ... · pharmacologic nutrition Kaveh eslami Pharm.D, board certified clinical pharmacy resident Tehran university of medical

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کبرگبه تغذیه وریدی و روده ای

سوء تغذیه

مدرس:دکتز اسالمی

Clinical and

pharmacologic

nutrition

Kaveh eslami

Pharm.D, board certified clinical pharmacy resident

Tehran university of medical science

Department of pharmacotherapy

ؼاـڀؽ، undernutritionڌب malnutritionغڃاچؽ ؽ، ټ٭ؽټبر س٥ؿڌڅ اوز؛ اڌځٱڅ زڅ ىبڀڋ ټٱٷ اـائڅ ثػڋ څ

غڃاچڍٻ اڌٿ س٥ؿڌڅ ـا اڀدبٺ ؼچڍٻ زڃـ ثبڌؽ ثڅ زڅ ىبڀڋ ټب ټڋ ثبڌىز س٥ؿڌڅ ټځڃ٠ڋ ـا سدڃڌك ځڍٻ ڂ اڌځٱڅ اٴف ټڋ

اڌٿ بـ ـا ثٱځڍٻ.

Effect of nutritional support on

clinical outcome in patients at

nutritional risk

Nutrition care is a vital component of

quality patient care

Malnutrition can increase length of stay in

hospital

Patients generally are considered at risk

of nutrient depletion and associated

increased morbidity and mortality

Clinical Nutrition (2004) 23, 539–550

ڌب ټفا٬جز چبڊ س٥ؿڌڅ اڊ اوز؛ ڌٱڋ اق nutrition support ڌٱڋ اق اخكاڊ ثىڍبـ ټڇٻ ؼـ ټفا٬جز اق ثڍٽبـ ثطث

ث س٥ؿڌڅ اوز. ڌ١ځڋ اٴف ثطث س٥ؿڌڅ ـا ټىبئٹڋ څ ـاثڅ ثىڍبـ ڀكؼڌٯ ثب ټؽر ثىشفڊ ؽپ ؼـ ثڍٽبـوشبپ ؼاـؼ ثط

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االش ڀٽبڌڍٻ قټبپ ثىشفڊ ؼـ ثڍٽبـوشبپ بچ دڍؽا ټڋ ځؽ څ اڌٿ چٻ اق خڇز والټز ثڍٽبـ ڂ چٻ اق ڀف ـبڌز

ضبئك اچٽڍز اوز. cost ڀكؼڌٱبپ ثڍٽبـ ڂ اق چٽڅ ټڇٽشف اق ڀف

PHARMACOECONOMIC

CONSIDERATIONS

Malnourished patients have increased

complications during their hospital course and

an increased length of stay (LOS), and thereby

incur increased health care costs.

Low serum albumin concentrations has been

shown to affect the complication rate, thereby

influencing hospital and ICU LOS.

Tucker HN, Miguel SG. Cost containment through nutrition intervention (Review). Nutr Rev 1996;54:111–121.

Kudsk KA, Tolley EA, DeWitt RC, et al. Preoperative albumin and surgical site identify surgical risk for major postoperative

complications. JPEN J Parenter Enteral Nutr 2003;27:1–9.

ځڍٻ؟ ثطث س٥ؿڌڅ ټڋ سڃاڀؽ ڌٯ ثطث ٠ٽڃټڋ ثبؽ ڂ ثفاڊ چٽڅ اـقٽځؽ اوز. زفا ټب ؼـ ټڃـؼ ثڍٽبـاپ طجز ټڋ

ثڍٽبـاپ ا٨فاؼڊ چىشځؽ څ غڍٹڋ ؼـ ـڌىٯ ٽجڃؼ ټىبئٷ س٥ؿڌڅ اڊ چىشځؽ چٽڅ ټب ثڅ غبف ټڋ آڂـڌٻ ىبڀڋ ـا څ

ڂ ثڅ غبڀڅ ڂاـؼ ثڍٽبـوشبپ ؽڀؽ ڂ ث١ؽ اق زځؽ ـڂق ٠ٹڋ ـ٤ٻ ضٽبڌز چبڊ اڀدبٺ ؽڄ ثب بچ ڂقپ ټڃاخڅ ؽڀؽ

ثبقٴشځؽ ٴڃڌڋ خكڌڋ اق ڂا١٬ڍز ؽڄ څ چف ىڋ ؼـ ثڍٽبـوشبپ ثىشفڊ ټڋ ڃؼ ثبڌؽ ڂقڀ ٻ ڃؼ. ؼـ ڀڇبڌز

ټٽٱٿ اوز ا٨كاڌ ڌبثؽ ڂ چٻ ټڍكاپ mortality ضشڋ اٴف اڌٿ ثڍٽبـاپ ؼزبـ بچ ڂقپ ڀڃڀؽ، چٻ ټڍكاپ

morbidity څ ثفاڊ آپ ٨فؼ ؼـ ڋ ؼڂـاپ ثىشفڊ اس٩ب٪ ټڋ ا٨شؽ ڌ١ځڋ ټڍكاپ ټفٲ ڂ ټڍف ڂ ټڍكاپ اس٩ب٬بر ڀبٴڃاـڊ

قڌبؼ ڃؼ.

چىشځؽ ڂ ټڍكاپ ب٨ڋ ضٽبڌز س٥ؿڌڅ اڊ ؼـڌب٨ز ڀٽڋ ځځؽ malnourishedټبٸ١بر اثجبر فؼڄ اڀؽ ا٨فاؼڊ څ

complication چبڊ ثڍشفڊ ثڅ چٻ ټڋ قڀځؽ. ٨ف ځڍؽ ٨فؼڊ څ ټڋ غڃاچؽ خفاضڋ ځؽ اٴف ٬فاـ اوز څ ؼڂ ـڂق ؼـ

قغٻ ڂ ټٱالر ؼڌٵف ؼڌف ثڇجڃؼٽبـوشبپ ثٽبڀؽ ڂ وذه ثڋ چڍر ټٱٹڋ ټفغ ڃؼ ټٽٱٿ اوز ؼزبـ ٩٠ڃڀز، ثڍ

ڃؼ څ ؼـ ڀڇبڌز ټځدف ثڅ ا٨كاڌ قټبپ ثىشفڊ ڂ چكڌځڅ ټڋ ڃؼ.

ثڅ ٠ځڃاپ ڌٯ ټ١ڍبـ ثفاڊ اـقڌبثڋ ڂ١ڍز س٥ؿڌڅ اڊ اق آٸجڃټڍٿ اوش٩بؼڄ ټڋ ڃؼ. ڀبپ ؼاؼڄ ؽڄ ثڍٽبـاپ ثىشفڊ ؼـ

ICU ڀؽاشڅ څ ټڍكاپ آٸجڃټڍٿ ٽشفڊ ؼاشځؽ ټؽر ا٬بټشبپ ثڍشف ثڃؼڄ. ده ټڋ ثڍځڍٻ اٴف ضٽبڌز س٥ؿڌڅ اڊ طڍص

ا٨كاڌ دڍؽا ټڋ ځؽ، ثڍٽبـڊ قاڌڋ ؼـ غڃؼ ثڍٽبـوشبپ ثڍشف ټڋ ڃؼ ڂ ؼـ ڀڇبڌز ثڍٽبـ ثبڍٻ، ټٱالر ټفٲ ڂ ټڍف

ټدجڃـ اوز ثڍشف ؼـ ثڍٽبـوشبپ ثٽبڀؽ.

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Malnutrition

Malnutrition results in:

Muscular atrophy

Delayed wound healing

Immunodeficiency and increased

risk of infections

Increase hospital stay

Increase cost

Malnutrition ڌب وڃء س٥ؿڌڅ زڅ دڍبټؽچبڌڋ غڃاچؽ ؼاز؟ ټٽٱٿ اوز ٨فؼ ؼزبـmuscular atrophy آـاٺ ڂڃؼ

قغٻ چبڌڋ څ ثف اثف خفاضڋ ثڅ ڂخڃؼ آټؽڄ ، اٴف س٥ؿڌڅ ټځبوت ؼـ ڀف ٴف٨شڅ ڀڃؼ، قغٻ سطٹڍٷ ټڋ ـڂؼ. آـاٺ ٠الر

ڃڀؽ ثڅ اڌٿ ټ١ځب څ وڍىشٻ اڌٽځڋ ؼـ immunodeficiency پ ؼزبـ چب ؼڌف ثڇجڃؼ دڍؽا ټڋ ځؽ. ټٽٱٿ اوز ثڍٽبـا

ڃـر ٽجڃؼ س٥ؿڌڅ اڊ ؼزبـ ڀ٭ ټڋ ڃؼ ثځبثفاڌٿ اڌٿ ا٨فاؼ ٩٠ڃڀز ثڍشفڊ دڍؽا ټڋ ځځؽ څ قټبپ ثىشفڊ ؽپ ڂ

cost ا٨كاڌ ټڋ ڌبثؽ.

Malnutrition definition

intake is inadequate to meet nutritional

requirements for 5 to 7 days or when

weight loss exceeds 10% of pre-illness

weight within a 3-6 month period

Based on body mass index (BMI) of less

than 18.5 kg/m2

malnutrition تعزیف

ـوشبپ اق ؼوز ثؽچؽ ـا چځٵبٺ ڂـڂؼ ثڅ ثڍٽب " اق ڂقپ10ـڂق ؼـڌب٨ز ڀٱځؽ ڌب 7سب ٨5ڋ ـا ڋ ىڋ څ ټڍكاپ س٥ؿڌڅ ب

ثبؽ، ؼزبـ وڃء س٥ؿڌڅ اوز.ؼاشڅ 5/18ٽشف اق BMIڂ٬شڋ ڂاـؼ ثڍٽبـوشبپ ټڋ ڃؼ، ڂ ڌب اق اثشؽا

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Kind of deficiency

In general, deficiency states can be

categorized as those involving protein

and calories or single nutrients such as

individual vitamins or trace elements

Protein calorie malnutrition can be

classified as

Marasmus

Kwashiorkor

Mixed marasmus/kwashiorkor

زڅ ڀڃ وڃء س٥ؿڌڅ اڊ ټڋ سڃاڀڍٻ ؼاشڅ ثبڍٻ؟

ؼـ بٸفڊ ٽجڃؼ ؼاشڅ ثبؽ ڂ ڌب ؼـ چف ؼڂڊ اڌځڇب. اق وڃڊ ٨٭ اوز ٨فؼ ٨٭ ٽجڃؼ دفڂسئڍٿ ؼاشڅ ثبؽ، ټٽٱٿ

ؼڌٵف ټٽٱٿ اوز ٨فؼ ٨٭ ڌٯ ټبؼڄ ټ٥ؿڊ ـا ٻ ؼاشڅ ثبؽ ڌ١ځڋ اٴف ٨فؼ ؼزبـ ٽجڃؼ ٨٭ ؼـ ڌٯ ڀڃ ڂڌشبټڍٿ ڌب

trace element ثبؽ، اڌٿ چٻ خكء وڃء س٥ؿڌڅ ج٭څ ثځؽڊ ټڋ ڃؼ.

ده چٽبڀڃـ څ ټڋ ثڍځڍؽ ټب اٴف ضشڋ س٥ؿڌڅ ب٨ڋ ثفاڊ ثڍٽبـ ثف٬فاـ ځڍٻ اټب اڀشػبة ټڃاؼ ٤ؿاڌڋ ټب ؼـوز ڀجبؽ،

چب څ ټٱٷ ضبؼ ڃـ ټب چىشځؽ ڂ trace element ټٽٱٿ اوز ٨فؼ ؼزبـ ٽجڃؼ ڃؼ. ټڃاؼڊ ڀڍف ڂڌشبټڍٿ چب ڂ

وش٩بؼڄ فؼپ ثفاڊ ثڍٽبـاپ ثىشفڊ ثڅ ڃـر سكـڌ٭ڋ ڀؽاـڌٻ.ټب ټشبو٩بڀڅ چڍر ڌٯ اق اڌځڇب ـا ثڅ ڃـر ـاڌح ثفاڊ ا

څ ؼـ اؼاټڅ سڃڍص ؼاؼڄ ضبال اٴف ٨فؼڊ ؼزبـ ٽجڃؼ دفڂسئڍٿ ڌب بٸفڊ ڃؼ، اڌٿ ټٱٷ ثڅ وڅ ڀڃ س٭ىڍٻ ټڋ ڃؼ

ټڋ ڃؼ.

Malnutrition; incidence

The incidence of malnutrition among

hospitalized patients has been reported

to be as high as 55%

" ڀبپ ټڋ ؼچؽ ڌ١ځڋ س٭فڌجب اق چف ؼڂ 55ا ـ malnutrition ثفـوڋ آټفڌٱبڌڋ چب ؼـ ڃـچبڊ دڍف٨شڅ ڍڃ

ټفڌ ڌٯ ڀ٩ف ؼزبـ ټٱٷ اوز څ اڌٿ اچٽڍز اڌٿ ټىبٸڅ ـا ڀبپ ټڍؽچؽ. ټبٸ١بر چٽٱبـاپ ټب ؼـ وبـڊ چٻ اڌٿ

.٬ڍڅ ـا بټال سبڌڍؽ ټڋ ځؽ

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CLASSIFICATION OF

NUTRITION DISEASE

Undernutrition usually results from:

1. starvation (inadequate nutrient intake)

2. Impaired absorption of nutrients

3. Altered metabolism (inappropriate use

of ingested nutrients)

ػڃـؼ. ټثال ثىڍبـڊ اق ثڍٽبـاپ ثڅ ؼٸڍٷ خفاضڋ ٨فؼ ثڅ ٠ٹٹڋ چڍر زڍك ڀټٽٱٿ اوز زفا وڃء س٥ؿڌڅ اڌدبؼ ټڋ ڃؼ؟

NPO ؼٸڍٷ ټٱالسڋ څ ؼـ ؼوشٵبڄ ټڍڃڀؽ ڂ چڍر ٤ؿاڌڋ ثڅ آڀڇب ؼاؼڄ ڀٽڋ ڃؼ ڌب اڌځٱڅ ٤ؿا ټڋ سڃاڀؽ ثػڃـؼ ڂٸڋ ثڅ

ثڅ ڂخڃؼ آټؽڄ، خؿة ڂڊ ټػشٷ ؽڄ اوز ڂ ضبٸز وڃٺ اڌځٱڅ ٤ؿا ڂ خؿة ب٨ڍىز ڂٸڋ ثف اثف اس٩ب٬بسڋ څ ؼـ ٴڃاـي

څ ؼزبـ ثڍٽبـڊ ٩٠ڃڀڋ ICUـ ټڋ ا٨شؽ، ټشبثڃٸڍىٻ ا٨كاڌ دڍؽا فؼڄ. ڌ١ځڋ ڀڍبق س٥ؿڌڅ اڊ ڌٯ ثڍٽبـ ثىشفڊ ؼـ ثؽپ ثڍٽب

ټش٩بڂر اوز. ثىڍبـ وز ثب ڌٯ ٨فؼ ٠بؼڊا

Marasmus

Marasmus is a chronic condition resulting from prolonged inadequate intake or use of protein and calories.

Somatic protein (skeletal muscle) and adipose tissue (subcutaneous fat) wastingoccurs

visceral protein production (e.g., albumin and transferrin) is usually preserved

Example Cancer

AIDS

Chronic starvation

انواع سوء تغذیه کمبود پزوتئین و کبلزی:

Marasmus

ؼ دفڂسئڍٿ ڂ بٸفڊ ټڋ ڃڀؽ ټبڀځؽ ڃؼبپ آ٨فڌ٭بڌڋ ؼزبـ وڃء س٥ؿڌڅ. ا٨فاؼڊ چىشځؽ څ ثڅ ڃـر ټكټٿ ؼزبـ ٽجڃ

اس٩ب٬ڋ څ ټڋ ا٨شؽ اڌٿ اوز څ ثؽپ ؼـ اڌٿ ټؽر دفڂسئڍٿ چبڊ وڃټبسڍٯ ټثٷ ٠الر ـا ٸڍك ټڋ ځؽ ڂ اق آڀڇب ثفاڊ

فثڋ چب ـا چٽبڀځؽ ڂ ٨فؼ ز ټڋ ځؽاوش٩بؼڄ ټڋ ځؽ. ٨فؼ بٸفڊ چٻ ٻ ؼاـؼ ڂ ثؽپ اق زفثڋ چب اوش٩بؼڄ آٸجڃټڍٿ وبغز

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جڍ١ڋ بپ ـا اڀؽاقڄ ٴڍفڊ ټڋ ځڍٻ ټڍكاپ آپ٠الس اق ؼوز ټڋ ؼچؽ. اڌٿ ا٨فاؼ ثىڍبـ ال٤فڀؽ ڂٸڋ ڂ٬شڋ څ آٸجڃټڍځ

اوز. قڌفا ثؽپ ثڅ چف ٬ڍٽشڋ آپ ـا ض٩ فؼڄ. اڌٿ ٨فؼ اؼٺ ڀؽاـؼ. آٸجڃټڍٿ ڌٱڋ اق اخكاڊ ثىڍبـ ټڇٻ اوز څ ثب

ؼاـڀؽ starvation ٺ خٹڃٴڍفڊ ټڋ ځؽ. ټثبٶ اڌٿ ا٨فاؼ ىبڀڋ چىشځؽ څ ثڃـ ٹڋ ڀٵڇؽاـڊ ټبڌ ؼـ ؼاغٷ ٠فڂ٪ اق اؼ

ثٹځؽ ټؽر ؼـٴڍف وفبپ چىشځؽ.ثڃـر ټبڀځؽ ىبڀڋ څ اڌؽق ؼاـڀؽ ڂ ا٨فاؼڊ څ

Kwashiorkor

Kwashiorkor develops when there is adequate calorie but inadequate protein intake.

These patients generally appear well nourished but are extremely catabolic, usually secondary to trauma, infection, or burns.

There is depletion of visceral (and to some degree somatic) protein stores with relative adipose tissue preservation, and hypoalbuminemia and edema are commonly seen.

In the setting of severe metabolic stress and protein deprivation, kwashiorkor may develop rapidly and may result in impaired immune function.

KWASHIORKOR

ڋ ټٽٱٿ اوز ؼاشڅ ثبځؽ، بچفبپ بټال ا٨فاؼڊ چىشځؽ څ دفڂسئڍٿ ب٨ڋ ؼـڌب٨ز ڀٽڋ ځځؽ. اڌٿ ا٨فاؼ بچف ؼـش

جڍ١ڋ ثبؽ ڂٸڋ ثڅ ؼٸڍٷ ټٱالر بسبثڃٸڍٱڋ ڀڍف سفڂټب ڂ ٩٠ڃڀز ؼزبـ ٽجڃؼ دفڂسئڍٿ ڃڀؽ. اڂٶ اق چٽڅ ثؽپ اق

دفڂسئڍٿ چبڊ غڃپ اوش٩بؼڄ ټڋ ځؽ ټثٷ آٸجڃټڍٿ ڂ ټ٭بؼڌف آپ ٻ ټڋ ڃؼ، ؼـ ټفاضٷ اثشؽاڌڋ اڌٿ اس٩ب٪ ټڋ ا٨شؽ زڃپ

ڋ څ ڃٶ ثٱؽ، دفڂسئڍٿ چبڊ ټطڍڋ ڀڍك اق ثڍٿ ټڋ ـڂڀؽ. ټشبو٩بڀڅ اڌٿ اس٩ب٪ بڌ اوز. ؼـ اڌٿ ثڍٽبـاپ ث١ؽ اق ټؽس

اڂٸڍٿ ټىبٸڅ اڊ څ اڌدبؼ ټڋ ڃؼ اغشالٶ ؼـ وڍىشٻ اڌٽځڋ ڂ ٩٠ڃڀز اوز، ٩٠ڃڀشڋ څ ثب ڂخڃؼ اوش٩بؼڄ اق اڀڃا

بوػڋ ثڅ ؼـټبپ ڀٽڋ ؼچؽ. ټشبو٩بڀڅ ٻ ڀڍىشځؽ ټػشٹ٧ آڀشڋ ثڍڃسڍٯ چبڊ ڂوڍ اٸڍ٧ ثڅ ؼٸڍٷ ٧١ وڍىشٻ اڌٽځڋ د

چبڊ ثڍٽبـوشبپ چبڊ ټب اق اڌځٵڃڀڅ ټٱالر ـڀح ټڋ ثفڀؽ، وڃء س٥ؿڌڅ آڀڇب ICUثڍٽبـاڀڋ څ ثڅ ڃـر ثٹځؽ ټؽر ؼـ

ثڍشف اق اڌٿ سڍخ اوز.

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Mixed

marasmus/kwashiorkor

That is a form of severe protein-calorie

malnutrition that develops in chronically ill,

starved patients during periods of

hypermetabolic stress.

There is reduced visceral protein synthesis

superimposed on wasting of somatic protein

and energy (adipose tissue) stores.

Immunocompetence is lowered, increasing

the incidence of infection, and wound

healing is compromised.

Risk factors for Undernutrition

disease state

complicating condition

Treatment

socioeconomic condition

altered metabolism

decreased nutrient intake

Malabsorption

وء تغذیه:س ایجبدریسک فبکتورهبی

ټثال ٨فؼڊ څ ثفاڊ ؼـټبپ ڀڃټڃڀڋ ثىشفڊ ؽڄ ؼـ ټ٭بڌىڅ ثب ٨فؼڊ څ ثڅ $ڊ ثڍٽبـ ، چبcomplicationڀڃ ثڍٽبـڊ،

ؼـټبپ چبڌڋ څ ثفاڊ ثڍٽبـ اوش٩بؼڄ #،ؼٸڍٷ سفڂټب ثىشفڊ ؽڄ ڂ وذه ؼزبـ ڀڃټڃڀڋ ڂ ٩٠ڃڀز ٬ىٽشڇبڊ ؼڌٵف ؽڄ

ڌ١ځڋ $څ ټفڌ اق ٬جٷ ؼاشڅ ڂ ؼاـؼ socioeconomicټڋ ڃؼ، ڂ١ڍز ټشبثڃٸڍٯ ٨فؼ، ڂ١ڍز خؿة، فاڌ

قټبڀڋ څ ټفڌ ڂاـؼ ثڍٽبـوشبپ ؽڄ س٥ؿڌڅ ټځبوجڋ ؼاشڅ، ڂقپ ټشځبوت ؼاشڅ ڌب ڀڅ اق ٬جٷ چٻ ڂ١ڍز غڃثڋ

اخبقڄ ټڋ ؼچؽ څ غبڀڃاؼڄ ٨فؼ ثڍبڌځؽ ڂ اق ڂڊ socioeconomic ڀؽاشڅ اوز ڂ آڌب ؼـ غڃؼ ثڍٽبـوشبپ چٽڍٿ فاڌ

# چٽڅ اق ـڌىٯ ٨بشڃـچبڊ اڌدبؼ وڃئ س٥ؿڌڅ ټڋ ثبځؽ.ؿڌڅ اڊ ؼاشڅ ثبځؽضٽبڌز س٥

وڃاٸڋ څ اڌدب ټفش اوز اڌٿ اوز څ ټب ؼاـڂوبقچب زفا ټڋ ثبڌىز ؼـ ټڃـؼ س٥ؿڌڅ زڍكڊ ثؽاڀڍٻ ڂ بـ ټب ثڅ ٠ځڃاپ

ځٱڅ ثفغڋ اق ثب ټشػ س٥ؿڌڅ زڅ س٩بڂسڋ ؼاـؼ؟ ثڅ ٠ٹز اڌ clinical pharmacist ؼاـڂوبق ڌب ؼـ وطڋ ؼڌٵف

ثڍٽبـاپ ڀڍبقټځؽ س٥ؿڌڅ ټځڃ٠ڋ چىشځؽ ڂ ڀٽڋ سڃاڀځؽ اق ٨فاڂـؼڄ چبڌڋ څ ټب ثڅ ٠ځڃاپ ٤ؿا ټڋ ځبوڍٻ ثڅ اڌٿ ٱٷ

ټػ ټڋ ڃؼ. ؼـ اڌځدب ڀ٭ ټب ؼاـڂوبقاپڅ اوش٩بؼڄ ځځؽ ڂ ؼـ ڂا٬ ڀڍبقټځؽ ؼاـڂچبڊ س٥ؿڌڅ اڊ چىشځؽ،

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INDICATIONS FOR

ARTIFICIAL NUTRITION

SUPPORT

1. Preexisting nutritional deprivation Involuntary weight loss of ≥ 10% within last 3-6

months

Based on body mass index (BMI) of less than

18.5 kg/m2

2. Anticipated or actual inadequate energy

intake by mouth

3. Significant multiorgan system disease

ؼاـڀؽ چٽبپ ا٨فاؼڊ چىشځؽ څ ڀڍبقټځؽ malnutritionؼاـؼ ؟ ا٨فاؼڊ څ بـثفؼ nutrition supportڊ زڅ ا٨فاؼؼـ

اڌٿ ڀڃ س٥ؿڌڅ چىشځؽ ده ټڋ ثڍځڍؽ څ س١ؽاؼ ثىڍبـ قڌبؼڊ اق ثڍٽبـاپ ټب ڀڍبقټځؽ اڌٿ ڀڃ اق س٥ؿڌڅ چىشځؽ ڌ١ځڋ ا٨فاؼڊ

ثبؽ 18.5بپ ٽشف اق BMIاؼڄ ثبځؽ ، ا٨فاؼڊ څ " اق ڂقپ ثؽڀبپ ـا ڀىجز ثڅ ڂقپ ٴؿشڅ بپ اق ؼوز ؼ10څ

ڂ ڌب اڌځٱڅ ثڍٽبـ االپ ټڍكاپ س٥ؿڌډ ب٨ڋ ؼـڌب٨ز ڀٽڋ ځؽ ڌ١ځڋ ثڍٽبـڊ اوز څ اشڇب ڀؽاـؼ ڂ زڍكڊ ڀٽڋ سڃاڀؽ ثػڃـؼ ڌب

ثػڃـؼ . ڌب اڌځٱڅ ټب ضؽن ټڋ قڀڍٻ ؼـ زځؽ ـڂق آڌځؽڄ ڀشڃاڀؽ ٤ؿا Cancerسڇڃ غڍٹڋ ؽڌؽ ؼاـؼ ، ټثٷ ثڍٽبـاپ ؼزبـ

ؼـ اثف ؼـٴڍفڊ ثبزب٬ڃ بټال اوڍت ؼڌؽڄ ثڃؼ ، څ ثڍٽبـوشبپ وڍځب ؼاشڍٻ ، خڃاڀڋ ثىڍبـ سځڃټځؽ ICUؼـ caseڌٯ

ثڃؼ ، ثؽٸڍٷ اڌځٱڅ ـڂؼڈ ڂڊ بټال آوڍت ؼڌؽڄ ثڃؼ ڂ چڍسٵڃڀڅ ٤ؿاڌڋ اق ـاڄ غڃـاڋ NPOده اق ځشفٶ فاڌ ثڍٽبـ

ثڃؼ 25اي چٻ ثڍشف اق BMIڃؼ ڂ بچ ڂقپ چٻ دڍؽا ڀٱفؼڄ ثڃؼ ، ث غڃةڀٽڍشڃاڀىز ثػڃـؼ . اڌٿ ټفڌ ڂقڀ

ـڂقآڌځؽڄ سڃاڀبڌڋ ٤ؿا غڃـؼپ ـا ڀػڃاچؽ ؼاز ثځبثفاڌٿ اق ـڂق اڂٶ ثفاڊ 5-10ڂٸڋ اـقڌبثڋ اڌٿ ثڃؼ څ اڌٿ ثڍٽبـ ؼـ

وشبپ ټفغ ڍٹڃ بچ ڂقپ اق ثڍٽبـ 6ق چٻ ثب اڌٿ ضبٶ ثب فڂ فؼڌٻ ڂ چف ـڂق ټبڀڍشڃـ ټڋ ؽ ثب TPNټفڌ

ڍت چبڊ ؽڌؽ ڂ ټفغ ؽ ثڍٽبـڊ ثب آپ آو ICUـڂق اق 7. اڌٿ ټفڌ ؼـ اثف چٽڍٿ ضٽبڌز س٥ؿڌڅ اڊ ؼـ ٠ف ؽ

ـڂق ټڋ ؽ. ثىڍبـڊ اق ثڍٽبـاڀڋ 14-13. اٴف ضٽبڌز س٥ؿڌڅ اڊ اڀدبٺ ڀٽڋ ؽ ، ڃٶ ثىشفڊ ڂڊ خؽڊ څ غڃـؼڄ ثڃؼ

اڌٿ س٥ؿڌڅ چىشځؽ ټثٷ ټفڌ چبڊ ؼڌبٸڍكڊ څ ڀڍبق چبڊ غبڋ ثڅ ؼاـڀؽ ، ڀڍبقټځؽ Multi organ dysfunctionڅ ڌٯ

. ڂ... دفڂسئڍٿ ؼاـڀؽ ، ټفڌ چبڊ وفبڀڋ

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Route of administration

Enteral nutrition

Parenteral nutrition

Current trend in Iran!!!

؟داریمچه نوع حمبیت تغذیه ای مصنوعی مب

ڀڃ ؼڌٵف اڌٿ اوز څ ـا ثڅ ثڍٽبـ ثفوبڀڍٻ ـا ثؽچڍٻ ، ڌ١ځڋ اق ـاڄ ـڂؼڄ ٤ؿاڀڃ اڂٶ اڌٿ اوز څ بټال جڍ١ڋ ثبؽ ،

. فاڂـؼڄ چبڊ ڂـڌؽڊ اوش٩بؼڄ ڀٽبڌڍٻاوش٩بؼڄ فؼ ټڋ سڃاڀڍٻ اق ٨ ڀشڃاپڀجبؽ ڂ ڌب اق ـڂؼڄ Functionalاٴف ـڂؼڈ ثڍٽبـ

-

32 5

16

22 9

ٴبڂالثڍٽبـوشبپ زڍىز؟

ب٨څ ڂ زفظ ټڋ ځځؽ ڂ ثڅ چٽفاڄ چٽبپ ؼـ ڂا٬ ټڃاؼ ٤ؿاڌڋ ټبڀځؽ ٴڃز ڂ ټف٢ ـا څ دػشڅ اڀؽ ټ٭ؽاـڊ ثفڀح ثڅ آپ ا

آة ٴڃز ثب دبـذ چبڊ دالوشڍٱڋ آټبؼڄ فؼڄ ڂ ثڅ ټفڌ ټڋ ؼچځؽ . ثب ڍڃڈ سدڃڌك ثب وفڀٳ څ اڌٿ ټىئٹڅ بټال چٻ

ابـڄ غڃاچؽ ؽ څ ڌٯ Enteral nutritionـڂسڍٿ اوز . ڂ اڌٿ ټطٹڃٶ ٴبڂال ؼـ چٽڅ خب ټ١فڂ٦ اوز . ؼـ ٬ىٽز

ثبڌؽ اڀفلڊ ؼاشڅ ثبؽ ؼـ ثڇشفڌٿ ضبٸز ، ج٫ اـقڌبثڋ څ اوبسڍؽ اڀدبٺ ؼاؼڀؽ ؼـ 1kcal/mlا٬ٷ ټطٹڃٶ اوشبڀؽاـؼ ضؽ

بڌىز ؼـڌب٨ز ځؽ ، ؼـڌب٨ز اڀفلڊ ـا څ ټڋ ث 1/5ټفڌ ؼـڀڇبڌز .اڀفلڊ ټڋ ؼچؽ 0.5kcal/mlوبـڊ اڌٿ ټطٹڃٶ

" 16ټڍكاپ ټڃـؼ ڀڍبق ڂ دفڂسئڍٿ 1/3 ڌ١ځڋ ثڃؼ"32.5. ؼـ ټبٸ١ډ وبـڊ ټڍكاپ اڀفلڊ قاڌڋ ؼـ ثڇشفڌٿ ضبٸز ټڋ ځؽ

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" 55ؼـ ڀف ثٵڍفڌؽ ڃـ چبڊ دڍف٨شڅ ثب وڍىشٻ چبڊ غب غڃؼبپ ضبٶ. ټڃـؼ ڀڍبق 1/5ڌ١ځڋ ٽشف اق

malnutrition ؟ټب ؼـ زڅ ڂ١ڋ چىشڍٻ. ڂؼاـڀؽ

How can a

Pharmacotherapist help?

Nutrition assesment

Energy requirement Calculation

Route of administration

Formula selecting

Administration techniques

IV admixture

Monitoring

ق ثبٸڍځڋ ثبؽ آڀڇب ټڋ سڃاڀځؽ اق اڌٿ اثكاـچب ثفاڊ ڂ٬شڋ څ اثكاـ چبڊ ټځبوت ؼـ ؼوز ټشػ س٥ؿڌڅ ڂ ڌب ؼاـڂوب

ڌب ڌٯ ؼاـڂوبق ټڋ pharmacotherapist ،clinical pharmacistس٥ؿڌڅ ؼـوز ثڍٽبـ اوش٩بؼڄ ڀٽبڌځؽ . زڃـ ڌٯ

؟ ٽٯ ڀٽبڌؽ ثڍٽبـ سڃاڀؽ ؼـ س٥ؿڌڅ

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NUTRITION ASSESSMENT

By identifying at-risk individuals, nutrition

screening can be a cost-effective way to

help decrease complications and length

of hospital stay.

A comprehensive nutrition

assessment should include:

Nutrition-focused medical and dietary

history

Physical examination including

anthropometric measurements and

laboratory measurements

Determining the patient’s nutrition

requirements

Determining the optimal type and timing

of nutrition intervention

ټڍكاپ ڀڍبق ثڅ اڀفلڊ ثڍٽبـ ـا ټطبوجڅ فاڌ س٥ؿڌڅ اڊ ضبٶ ضبف ثڍٽبـ ـا اـقڌبثڋ ڀٽبڌؽ. ؼڂٺ اڌځٱڅ بڌؽث اڌځٱڅ اڂٶ

$غڃـاڋ ڌب ڂـڌؽڊ # ټڇٽشف اڌځٱڅ ده ڂ وف٠ز س٥ؿڌڅ ؼـ ثڍٽبـ ـا ټػ ڀٽبڌؽ.اڀفلڊ ؼـڌب٨ز وڃٺ اڌځٱڅ ـاڄ.ڀٽبڌؽ

ؽڄ ثفاڂـؼڄ ڂڊآڌب ڀڍبق س٥ؿڌڅ اڊ ټػ ڃؼ ڃؼ سب اق اڌځٱڅ س٥ؿڌڅ ثفاڊ ټفڌ فڂ ؽ ، ټفڌ ثبڌؽ اـقڌبثڋ

؟اوز

ځڍٻ ، ثځبثفاڌٿ Adjustmentټفڌ ثف اثف س٥ؿڌڅ اڊ څ ټب ؼاؼڌٻ ؼزبـ ټٱٷ ڀؽڄ ؟ ثبڌؽ ټفست اڌٿ وڍىشٻ ـا آڌب

ؼـ آټفڌٱب ڌٯ ٨ٹڃڍخ ڂ ڌٯ clinical pharmacyؼاـڂوبق ثڃـ ټفست ؼـ س٥ؿڌډ ثڍٽبـ ؼغڍٷ اوز ، ضشڋ ؼـ ـشډ

ڂ س٥ؿڌڅ ڂخڃؼ ؼاـؼ. TPNـشډ سػڋ ثفاڊ

زڃـ اـقڌبثڋ ځڍٻ؟

ځبوبڌڋ ځڍٻ . ثبڌؽ ىبڀڋ څ ؼـ ڂ١ڍز وڃء س٥ؿڌڅ چىشځؽ ـا ڂ اوزټفش screeningثطث ؼـ اڌځدب

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CLINICAL EVALUATION

medical and dietary history

physical examination

objective evaluations (e.g., laboratory parameters and anthropometric measurements).

ڃـ ٤ؿا ټڋ غڃـؼڄ ، ثٵڍفڌٻ ، سب ځڃپ زفش ضبٶ ثف اوبن ټىبئٷ س٥ؿڌڅ اڊ اڂٶ اق چٽڅ ثبڌؽ اق ټفڌ

ڂقڀ زڃـ ثڃؼڄ ،زڅ ؼاـڂچبڌڋ ټف٦ ټڋ فؼڄ ، زڅ ثڍٽبـڊ چبڌڋ ؼاـؼ . ڌٯ ثفـوڋ ٹڋ ثؽڀڋ اڀدبٺ

ؼچڍٻ ټثٷ اڌځٱڅ ثجڍځڍٻ آڌب ٴڃڀڅ چبڊ ثڍٽبـ ٨فڂـ٨شڅ اوز ، آڌب ٬ىٽز چبڊ ش٩ ٨فڂـ٨شڅ اوز ، ؼـ ڂا٬ آپ

ڌٯ ده .آوڍت ټڋ ڃڀؽ ڂ١بپ زڃـ اوز ؼزبـ ٬malnutritionىٽز چبڌڋ څ قڂؼسف اق چٽڅ ؼـ اثف

ؼچڍٻ ڂ ټڋ ٴڍفڌٻ ، ڌٯ ټ١بڌځډ ثؽڀڋ ٹڋ اق ثڍٽبـ اڀدبٺ ټڋ اق ټفڌ medicalفش ضبٶ ؼاـڂڌڋ ، ٤ؿاڌڋ ڂ

ٱځڍٻ. ټڍاڀؽاقڄ ٴڍفڊ آٸجڃټڍٿ ـا ټثٷ ث١ڋ اق دبـاټشف چبڊ ټڇٻ ـا ثفاڊ س٥ؿڌڅ

physical examination

The nutrition-focused physical examination

consists of an assessment of

lean body mass (LBM)

physical findings of vitamin deficiency, trace

element deficiency, and essential fatty acid

deficiency.

The assessment should characterize the

presence and degree of muscle wasting,

edema, loss of subcutaneous fat, dermatitis,

glossitis, cheilosis, and/or jaundice

زڅ بـچبڌڋ اڀدبٺ ټڋ ڃؼ ؟ Physical examinationؼـ

ـا ټطبوجڅ ڀٽبڌڍٻ آڌب ٠الټز چبڌڋ lean body weightټڇٽشفڌٿ ٬ىٽز اڌٿ اوز څ ڂقپ ټفڌ ثفـوڋ ڃؼ ڂ

ټبڀځؽ اق ثڍٿ ـ٨شٿ ڋ٠الئٽ چبڊ فڂـڊ ؼاـؼ.Fatty acidڂ ٽجڃؼ Trace elementثف ٽجڃؼ ڂڌشبټڍٿ ، ټجځڋ

چف ڌٯ ڀبپ ؼچځؽڈ ټٱالر ؼڌٵف قثبپ ، ڂـٺ بڊ قڌف دڃوشڋ ، ټٱٷ ؼـټبسڍزڋ چ٠الر ، اؼٺ ، اق ثڍٿ ـ٨شٿ زفث

چبوز. trace elementڂخڃؼ ٽجڃؼ

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IBW and ABW

The IBW provides one population

reference standard

ABW can be compared to detect both

over- and undernutrition states

Evaluation of Actual Body

Weight

Shopbell JM, Hopkins B, Shronts EP. Nutrition screening and assessment. In: Gottschlich MM, ed. The Science and Practice

of Nutrition Support: A Case-Based Core Curriculum, America Society for Parenteral and Enteral Nutrition. Dubuque, IA,

Kendall/Hunt, 2001:107–140.

Actual bodyڂ ؼڌٵفڊ Ideal body weightؽاٺ ڂقپ ـا ثبڌؽ اڀؽاقڄ ٴڍفڊ ڀٽبڌڍٻ ؟ ؼڂ ڂقپ غڍٹڋ ټڇٻ اڀؽ ڌٱڋ

weight زڅ ٽٱڋ ثڅ ټب ټڋ ځؽ؟ ،

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Ideal Body Weight

Calculation and Assessment

IBW س١ڍڍٿ فؼڄ اڀؽ ، ٨فټڃٸڋ چٻ ثفاڌ س١ڍڍٿ ؽڄ څ ثفاڊ چف ٨فؼڊ ټڋ سڃاڀؽ خٽ١ڍشڋ ـا ثف اوبن ټبٸ١بر

ف اوز ، ڌ١ځڋ اق ڂقپ ال٤غڍٹڋ ثڅ ټب ټڋ ٴڃڌؽ ٨فؼ ڀىجز ثڅ ڂقپ اڌؽڄ آٸ زڅ فاڌڋ ؼاـؼ، آڌب ABWټطبوجڅ ڃؼ.

ثبؽ ، IBW" اق 69اي ٽشف اق ABW. ټثال ټڋ ٴڃڌڍٻ اٴف ټفڌ ت اوز ڌب ټشځبوت اوز ڌب زب٪ اوزاڌؽڄ آٶ ٠٭

ثبؽ اڌٿ ٨فؼ ڀفټبٶ ؼـڀف ٴف٨شڅ 120-90اوز ، اٴف ثڍٿ scaleؼزبـ وڃء س٥ؿڌډ ثىڍبـ ؽڌؽ اوز . اڌٿ ؼـ ڂا٬ ڌٯ

ـا څ ثف اوبن ٬ؽ ڂ IBWؼ اڌٿ بغ ثفاڊ غبڀٽڇب ڂ آ٬بڌبپ ټش٩بڂر اوز . ؼاـؼ. ٠ؽ ٨فټڃٶ IBWټڋ ڃؼ. ټطبوجډ

.ـا ثب ٬فاـ ؼاؼپ ټفڌ ـڂڊ سفاقڂ ثؽوز ټڋ آڂـڌٻ ABWوٿ ڂ خځه ټطبوجڅ ټڋ ځڍٻ ڂ

Change in weight over

time ‘usual body weight’

Use of the UBW as a reference point provides a more accurate reflection of clinically and nutritionally significant weight changes.

The use of UBW avoids the problems of normative tables, and it documents comparative changes in body weight

Determining a patient’s UBW depends on patient or family recall, which may be inaccurate

In adults, unintentional weight loss of more than 10% in less than 6 months has been correlated with a poor clinical outcome

Usual body weight ؼـ ڍٹڃ ڂقڀ ثڃؼڄ ڂ ٨120ف ټڋ ځڍٻ خڃاڀڋ ثڃؼڄ څ ؼاـؼ. ټفڌ ٠ٽڃټب څاوز ڂقڀڋ

ټفڌ االپ ثؽر ڂٸڋ اڌٿ س٩بڂسڋ ڀؽاـؼ IBW، ؼـ اـقڌبثڋ ثب ؽڄ اوز ڍٹڃ 80 ټبڄ اغڍف 4-٠3ف

malnourished ټبڄ اغڍف اق ؼوز ـ٨شڅ 6" اق ڂقپ ؼـ 10اٴف اوز .ڂقپ اق ؼوز ؼاؼڄ قڌفا ټ٭ؽاـ قڌبؼڊ اوز

.ٴڍفڌٻ ؼـ ڀف ټڋ malnutritionثڅ ٠ځڃاپ ثڍٽبـ ـا ثبؽ ټب

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" 85-75 ثڍٿ ، ؼاـؼ غ٩ڍ٧ malnutritionثبؽ ٨فؼ usual body weight " 85-95ثڍٿ ف ڂقپ ٨فؼاٴ

malnutrition 75ټشڃو ڂ ٽشف اق "severe malnutrition ؼاـؼ.

BIOCHEMICAL AND IMMUNE

FUNCTION STUDIES

LBM includes skeletal muscle, somatic protein, and functional proteins such as circulating proteins and the visceral proteins

Biochemically, LBM can be assessed by measuring the serum visceral proteins, albumin (ALB), transferrin (TFN), and prealbumin.

prealbuminآپ اوش٩بؼڄ ټڋ ڃؼ ، آٸجڃټڍٿ اوز ، ؼڂ بغ ؼڌٵف ڌ١ځڋ څ ٠ٽال اق ټڇٽشفڌٿ بغ آقټبڌٵبچڋ

. ٨ف٪ اڌٿ ؼـ ؼوشفن ڀڍىشځؽ ڂ ثڍشف ثڃـر فش چبڊ سط٭ڍ٭بسڋ ټفش اڀؽ. غڍٹڋ څڂ سفاڀى٩فڌٿ چٻ ڂخڃؼ ؼاـڀؽ

زڍىز؟ بغڇب ؼـ

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Visceral Proteins Used for

Assessment of Lean Body Mass

Erstad BL, Campbell DJ, Rollins CJ, Rappaport WD. Albumin and prealbumin concentrations in patients

receiving postoperative parenteral nutrition.Pharmacotherapy 1994;14:458–462

ټٽٱٿ ؽځدڍؽا malnutritionثځبثفاڌٿ اٴفټفڌڋ اق چٽڍٿ االپ ؼؼاـ ـڂق 20-18آٸجڃټڍٿ ڀڍٽڅ ٠ٽف ثىڍبـ ڃالڀڋ

دبڌڍٿ ثڍبڌؽ ڂ ثبٸ١ٱه ڂ٬شڋ ٽب ټفڌڋ ـا ټڋ ثڍځڍؽ څ آٸجڃټڍٿ ثىڍبـ غڃڀ ـڂق ڃٶ ثٱؽ سب آٸجڃټڍٿ 10اوز

بغ ، وفڌ ـڂق ڃٶ ټڍٱؽ سب آٸجڃټڍٿ ثبال ثڍبڌؽ ثځبثفاڌٿ اڌٿ 10چ٩شڅ سب 1ضؽا٬ٷ س٥ؿڌڅفڂ ثب دبڌڍځڋ ؼاـؼ

اڀؽاقڄ ڀڍٽڅ ٠ٽف ڃسبڄ سفڊ ؼاـؼ ڂ ؼـ آقټبڌٵبڄ ټثٷ ثڍٽبـوشبپ دبـن بغڇب اق چٽڅ prealbumin ڂٸڋڀڍىز ،

ؼـ ضبٶ ثبال ـ٨شٿ اوز prealbuminـڂق ث١ؽ 2اٴف ثفاڊ ټفڌ س٥ؿڌډ ؼـوشڋ ؼـ ڀف ٴف٨شڅ ڃؼ ٴڍفڊ ټڋ ڃؼ.

ـا اڀؽاقڄ ثٵڍفڌؽ ټشڃخڅ ټڋ ڃڌؽ څ ټفڌ ؼـ ٠ف prealbuminاٴف ثف٠ٱه ڂ ڂ ټفڌ ثڇشف ټڋ ڃؼ ڌب

زځؽ ـڂق ٴؿشڅ اق ڂ١ڍز س٥ؿڌڅ اڊ غڃثڋ ثفغڃـؼاـ ڀجڃؼڄ اوز ، چفزځؽ ټٽٱٿ اوز آٸجڃټڍځ جڍ١ڋ ثبؽ.

ENERGY REQUIREMENTS

simple approach

20 to 25 kcal/kg for healthy adults

25 to 30kcal/kg for malnourished or mildly

metabolically stressed adults,

30 to 35 kcal/kg for critically ill or hypermetabolic

adults

35 to 40 kcal/kg for adults with major burns.

Unfortunately, this simple approach fails to

consider age- and gender-related differences in

energy metabolism

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol,

Protein, and Amino Acids. September 5, 2002. http://www.nap.edu/books/ 0309085373/html/. Accessed June 4, 2004

ثف kcal /kg 25-20فاؼ وبٸٻ ، ټثال ثفاڊ ا٨اڌٿ اوز څ ټطبوجڅ ځڍٻ. ، ڌٯ ـاڄ وبؼڄ اڀفلڊ ټڃـؼ ڀڍبق ثڍٽبـ ـا زڃـ

اوش٩بؼڄ فؼ ، ټفڌڋ اوز څ ڂقڀ IBWټڋ سڃاپ اق اٴف ثڍٽبـ ثىڍبـ ال٤ف اوز . ؼـ ڀف ثٵڍفڌٻABWاوبن ڂقپ

ثب سڃخڅ ثڅ س٩بڂر چب اوش٩بؼڄ ABWاوش٩بؼڄ ټڋ ځڍٻ ؼـ ڀڇبڌز ټڍشڃاپ ثڃـ ٹڋ اق ABWثبالسف اوز ، اق IBWاق

30-25 ڍٽبـوشبپ ثىشفڊ چىشځؽ ڂاوشفن غ٩ڍ٩ڋ ؼاـڀؽ ټڍكاپ اڀفلڊ ټڃـؼ ڀڍبق ـا ثفاڊ ثڍٽبـاڀڋ څ ؼـ ثفؼ ،

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kcal/kg .ثڍٽبـاپ. ثفاڊ ؼـ ڀف ټڋ ٴڍفڌٻ critically ill ڌب ىبڀڋ څ ؼزبـ ټٱالرhyper metabolic چىشځؽ ټثٷ

40ىڍبـ ؽڌؽ ؼاـڀؽ سب ڂ ا٨فاؼڊ څ وڃغشٵڋ ث kcal/kg 35-30ىبڀڋ څ ست ؼاـڀؽ ڌب ٩٠ڃڀز غڍٹڋ ؽڌؽ ؼاـڀؽ ،

kcal/kg ثؽچڍٻ . اڀفلڊ ټڋ سڃاڀڍٻ ثڅ آڀڇب

پ ټڍشڃاڀڍٻ اوش٩بؼڄ ڀٽبڌڍٻ څ اق آؼاـؼ ، BMRڂخڃؼ ؼاـؼ څ چف ٨فؼڊ ڌٯ basal metabolic rateثطثڋ ثڅ ڀبٺ

ENERGY REQUIREMENTS

Daily energy requirements for children are

approximately 150% of basal metabolic rate

(BMR) with additional calories to support

activity and growth

Requirements increase with fever, sepsis,

major surgery, trauma, burns, long-term growth

failure, and chronic conditions (e.g.,

bronchopulmonary dysplasia, congenital heart

disease, and cystic fibrosis).

، سفڂټب ، surgeryؼـ ثكـٴىبالپ ٠ڃاټٹڋ ټثٷ اوز ڂٸڋ BMRثفاثف 150ؼـ ا٩بٶ اڀفلڊ څ ڀڍبق ؼاـڀؽ س٭فڌجب

سأثڍف ٴؿاـ اوز . آپ ـڂڊ COPDټثٷ وڃغشٵڋ ، ټٱالر ټكټٿ

Equations to Estimate Basal Energy

Expenditure in Adults and Children

Harris-Benedict (kcal/day)

Males: BEE = 66 + [(13 7W(kg)] + [5H(cm)] − (6 8A)

Females: BEE = 655 + [(9 6W(kg)] + [1 8H(cm)] − (4 7A)

BEE: basal energy expenditure

W: weight in kilograms (IBW or ABW)

ـا ٸطب ټڋ ځؽ ، ڂ ٬ؽ ڂ وٿ ڂ ڂخڃؼ ؼاـؼ ، اڌٿ ٨فټڃٶ ټكڌش اڌٿ اوز څ ڂقپ ٨Harris-Benedictفټڃٸڋ ثڅ ڀبٺ

ټڋ سڃاڀڍٻ ٨فټڃٶ ر اوز زڃپ ټڍكاپ ټشبثڃٸڍىٻ غبڀٻ چب ڂ آ٬بڌبپ ټش٩بڂر اوز. ثب اڌٿ ؼـ غبڀٻ چب ڂ آ٬بڌبپ ټش٩بڂ

BMR ـا ثڃـسڋ ټطبوجڅ ځڍٻbasal energy expenditure ٨فؼ ڀڍبق ؼاـؼ ـا ټطبوجڅ ټڍكاپ اڀفلڊ دبڌڅ اڊ څ ڌب

.ڀٽبڌڍٻ

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ڌب cancer ،infection ڊ څځبثفاڌٿ ٨فؼٴ٩شڍٻ څ غڍٹڋ ٨ف٪ ټڋ ځؽ څ ٨فؼ ؼـ زڅ فاڌڋ اق ثڍٽبـڊ ٬فاـ ؼاـؼ ، ث

ثفاثف ا٨كاڌ دڍؽا ټڋ 2ڂ ضشڋ سب ټٱٷ ضبؼ ؼڌٵفڊ ؼاشڅ ثبؽ ، ټڍكاپ اڀفلڊ څ ڀڍبق ؼاـؼ ټش٩بڂر اوز ،

. ـا ؼـ آپ فة ټڋ ځڍٻ activity & stress factorـا ټطبوجڅ فؼڌٻ فڌجڋ ثڅ ڀبٺ basalڋ ټب .ثځبثفاڌٿ ڂ٬شؽځ

Total energy expenditure

TEE = BEE* Stress factor * activity factor

ـا ټطبوجڅ ڀٽبڌڍٻ ڂ ټڍكاپ ٷ اڀفلڊ څ ټڋ غڃاچڍٻ ثڅ ټفڌ ثؽچڍٻ اڂٶ total energyده ڂ٬شڋ ټب ټڋ غڃاچڍٻ

ټٱٷ ثڍٽبـ ڂ ټڍكاپ ١٨بٸڍز ڂ ضفز ثڍٽبـ ثڍبڌڍٻ ټڍكاپ اڀفلڊ دبڌڅ ـا ثب آپ ٨فټڃٶ ټطبوجڅ ڀٽبڌڍٻ ڂ ث١ؽ ثف اوبن

اڀفلڊ ټڃـؼ ڀڍبق ثڍٽبـ ـا ؼ٬ڍ٭ب ثؽوز ټڋ آڂـڌٻ فڌجڋ ـا ؼـ آپ فة ټڋ ځڍٻ ڂ ټڍكاپ

ڌ١ځڋ ثشڃاڀؽ اق ـڂؼڄ ؼاـؼ GI Functional؟ اٷ اڌٿ اوز څ اٴف ټفڌ زڅ ـاچڋ ثفاڊ س٥ؿڌڅ ثڍٽبـ اڀشػبة ځڍٻ

ثڃؼ functionalاي اوش٩بؼڄ ڀٽبڌؽ ، ثڇشفڌٿ ـاڄ س٥ؿڌڅ اڊ ثبق چٻ اوش٩بؼڄ اق س٥ؿڌډ ـڂؼڄ اڌىز. ده اٴف ـڂؼڈ ټفڌ

اوش٩بؼڄ ځڍٻ . parenteralچبڊ ؼڌٵف ټدجڃـڌٻ اق indicationڀجڃؼ ڂ ڌٱىفڊ functionalڂٸڋ اٴف enteralق ـاڄ ا

اوش٩بؼڄ ځڍٻ . enteral feedingڂ چف قټبڀڋ ټفڌ سڃاڀىز اق ـڂؼڄ اي اوش٩بؼڄ ڀٽبڌؽ ثبڌؽ اق

څ ؼـ وڃءس٥ؿڌڅ ټفش اوز دفڂسئڍٿ اوز ، ثڅ ٠ځڃاپ ڌٯ خك ټڇٻ ټطبوجڅ فؼڌٻ ، ٴ٩شڍٻ ڌٱڋ اق اخكا ټڇٽڋ ـا بٸفڊ

ڂٸڋ ث١ڋ ا٨فاؼ څ اوز 0.8gr/kg/dayثفاڊ ٨فؼ ثبٸ٣ وبٸٻ ضؽڂؼ RDAز٭ؽـ دفڂسئڍٿ ثبڌؽ ثڅ ثڍٽبـ ثؽچڍٻ ؟ ټڍكاپ

ثفوؽ. اټب 1.1غبڀٻ چبڊ ثبـؼاـ ثڅ ؼـ ڂ ثفوؽ 1ټىٿ سف چىشځؽ ټٽٱٿ اوز ڀڍبق دفڂسئڍٿ بپ ا٨كاڌ دڍؽا فؼڄ ڂ ثڅ

دڍؽا ټڋ ، ٩٠ڃڀز ڃؼټڋ sepsisؼزبـټڋ ڃؼ ، ICUدبوز څ ٨فؼ ڂ٬شڋ ؼزبـ ثڍٽبـڊ ټڋ ڃؼ ، ڂاـؼ ټٱٷ اڌځ

ا٨كاڌ دڍؽا ټڋ ځؽ. ده ټب ضشٽب ثبڌؽ اق ټطٹڃٸڋ ؼـ ڂڊ ، ټڍكاپ ڀڍبق ثڅ دفڂسئڍٿ ...، ټٱالر ـڌڅ دڍؽا ټڋ ځؽ ڂ ځؽ

ټشأو٩بڀڅ ثىڍبـڊ اق اڂ٬بر څ اق ٤ؿاچبڊ ثڍٽبـوشبپ اوش٩بؼڄ .اوش٩بؼڄ ځڍٻ څ ڀڍبق چبڊ دفڂسئڍځڋ ـا چٻ ثفآڂـؼڄ ڀٽبڌؽ

ځځؽ . ثفاڊ ٽڋ دفڂسئڍٿ ـا ثڅ اڀؽاقڈ ب٨ڋ ثفاڊ ټفڌ سأټڍٿ ڀ ڂٸڋ ټڋ ڃؼ اڌځڇب ټٽٱٿ اوز بٸفڊ ـا سأټڍٿ ځځؽ

بـوبڌڋ ث١ڋ اقټڃاـؼ ټثٷ ڀبـوبڌڋ ٹڍڅ ڂ ڀ ؼـ ڂبټال ټش٩بڂر اوز ټڍكاپ دفڂسئڍٿ ټڃـؼ ڀڍبق ثڍٽبـاپ ټػشٹ٧

.ؼاـڌٻ جؽڊ ټب ټطؽڂؼڌز ثفاڊ دفڂسئڍٿ

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Clinical decision algorithm

-1ـا ټطبوجڅ ټڋ ځڍٻ . ثفاڊ ثڍٽبـاپ ٠بؼڊ ٠ٽڃټب ثب دفڂسئڍٿ فاڌ ثڍٽبـ ټڍكاپ ثب سڃخڅ ثڅ ثڃـ غالڅ ده

1.2gr/kg ڂ ضىبة ټڋ ځڍٻ. ڂ ثڍٽبـاپ ڂا١٬ب ثؽ ضبٶcritically ill 2ـا سب gr/kg ڂسئڍٿ ټطبوجڅ ټڋ ځڍٻ . دف

ـا ؼاـڌٻ څ بټال Aminofusionاچٽڍز ؼاـؼ زڃپ ټب ټطٹڃٶ Parenteral nutritionثػڃ اڌٿ ټىئٹڅ ؼـ

بټال ټػ اوز . ؼـ چف ټڍٹڋ ٸڍشف آپدفڂسئڍځڋ اوز ڂ ټڍكاپ ٴفٺ دفڂسئڍٿ

PROTEIN

the RDA is 0.8 g/kg per day

In adults older than 60 years of age, protein needs are increased to 1 g/kg per day

Protein requirements are also higher in pregnant and lactating women (1.1 g/kg per day)

Critical illness (e.g., sepsis, burns, or trauma) will result in a hypercatabolic state in which there is increased protein synthesis and degradation(1.5 to 2 g/kg per day)

Liver failure typically results in the need for protein restriction (0.5 g/kg per day) except if a hypercatabolic state is also present

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty

Acids, Cholesterol, Protein, and Amino Acids. September 5, 2002. http://www.nap.edu/books/ 0309085373/html/. Accessed

June 4, 2004.

ثىڍبـ ټڋ سڃاڀؽ غفڀبٮ ثبؽ ، ټؽر malnutritionچىشځؽ ، malnutritionـ ده ثڃـ ٹڋ : ثڍٽبـاپ ټب ٠ٽڃټب ؼزب

ـا ؼـ ڀڇبڌز ا٨كاڌ mortalityچبڌڋ څ ثڃخڃؼ ټڋ آڌؽ چكڌځڅ ڂ complication ڂا٬بټز ؼـ ثڍٽبـوشبپ ، ٩٠ڃڀز چب

ـڂي چبڊ ټػشٹ٩ڋ ڂخڃؼ ڂ ټڋ ؼچؽ ، ثفاڊ غڍٹڋ اق ثڍٽبـاپ ټب ثبڌؽ ضشٽب ڌٯ ـاچڋ ثفاڊ س٥ؿڌډ ټځڃ٠ڋ ؼاشڅ ثبڍٻ

ؼاـؼ.

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تغذیه روده ای

مدرس:دکتز ابزیشمی

Definitions

EN

Tube feeding

When one or more steps in the normal process of obtaining nutrients from oral intake is disrupted

Some digestive and absorptive function must remain intact

سفٺ ٹڋ ڀبټڍؽڄ ټڋ ڃؼ څ ڌٯ Enteral Nutritionاوش٩بؼڄ ځڍٻ س١فڌ٧ : چف خب څ اق ؼوشٵبڄ ٴڃاـي ثفاڊ س٥ؿڌڅ

ثڅ ڂڊ ٤ؿا ـوبڀؽڄ ټڋ ڃؼ ؼـ اڌٿ س١فڌ٧ ostomyاوز ؛اق ٨فؼڊ څ ثب ٬ب٫ ٤ؿا ټڋ غڃـؼ سب ثڍٽبـڊ څ اق فڌ٫

٬فاـ ټڋ ٴڍفؼ .

Term ؼڌٵفڊ ثڅ ڀبٺtube feeding چفخبڌڋ څ ټب اق ڌٯ ٸڃٸڅ اڊ ڀڍف ڂ ؼاـڌٻNG tube ،OG tube ڂ ڌب ٸڃٸڅ چبڊ

ostomy اوش٩بڄ ځڍٻ ثڅ ڀبٺtube feeding ڂ ٹٽڅ اټب آپ زڍكڊ څ ثڅ ڃـ ٹڋ خب ا٨شبؼڄ اڌٿ ؼڃؼ. غڃاڀؽڄ ټڋ

ثڅ اڌٿ ټ١ځڋ اوز څ ثڅ ثڍٽبـ اق Tube Feedingڂ چٻ Enteral Nutritionټ١بؼٶ چٻ ؼـ ڀف ٴف٨شڅ ټڋ ڃؼ . چٻ

فڌ٫ ڌٯ ٸڃٸډ غب ٤ؿا ثفوبڀڍٻ.

قټبڀڍٱڅ ټب ټڋ غڃاچڍٻ اق ؼوشٵبڄ ٴڃاـي ثڍٽبـ اوش٩بؼڄ ځڍٻ ضشٽب ثبڌؽ ڌٯ ټ٭ؽاـڊ اق ١٨بٸڍز چب ٴڃاـڋ ثڍٽبـ وبٸٻ

ڄ ثبؽ څ ثشڃاڀؽ آپ س٥ؿڌڅ ـا چٻ ڂ خؿة ڀٽبڌؽ. ڂ ؼوز ڀػڃـؼ

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Functional Unit Major Steps Diseases

Oropharynx Chew and lubricate food; swallow

ALS, muscular dystrophy, severe RA, CVA, end-stage Parkinson, paralysis,

coma, anorexia: cardiac or CA cachexia, CKD, liver failure, neurologic disease

Esophagus Transport food to the stomachUlcer, CA, obstruction, fistula,

esophagectomy, CVA

StomachHold food for mixing and grinding; add

acid and enzymes; release chyme to small bowel; osmoregulation

Severe gastritis or ulceration, gastroparesis, gastric outlet

obstruction, gastric CA, severe GERD

DuodenumOsmoregulation; neutralize stomach

acidSevere ulcer, fistula, CA: gastric,

pancreatic

Small bowel Digestion; absorption

Fistula, severe enteric infection, malnutrition, malabsorption, Crohn,

celiac, ileus and dysmotility syndrome

Pancreas Secretion of digestive enzymesPancreatitis, pancreatic CA, pancreatic

injury, pancreatic fistula

ColonAbsorb fluid; ferment soluble fiber and

unabsorbed carbohydrate; absorb water

IBD, colon CA, colocutaneous fistula, colovaginal fistula, diverticulitis, colitis,

colon surgery

ثىشڅ ثڅ اڌځٱڅ ؽاٺ ٬ىٽز ؼوشٵبڄ ٴڃاـي ثڍٽبـ ؼزبـ ټٱٷ ؽڄ اوز ټب ټىڍف اثشؽاڌڋ س٥ؿڌڅ ـا اڀشػبة ټڋ ځڍٻ .

فؼپ ٤ؿا Lubricateكڌٻ چب ڂ ث١ځڃاپ ټثبٶ ٨ف ث٩فټبڌڍؽ بـ ؼچبپ څ خڃڌؽپ ، ټػٹڃ فؼپ ٤ؿا ثب ڌٱىفڊ اق آڀ

، ؼـ اڌٿ خب ، ؼزبـ ټٱٷ ڃؼ ټبڀځؽ ثفغڋ ثڍٽبـڌڇبڊ ڀڃـڂٸڃلڌٯ څ ثڍٽبـ سڃاپ خڃڌؽپ ڀؽاـؼ اوز ، اٴف ثڅ ؼٸڍٹڋ

ڌٯ ټفضٹڅ دبڌڍٿ سف ټڋ ـڂڌٻ ڂ ٤ؿا ـا اق آڀدب فڂ ټڋ ځڍٻ . ثىشڅ ڌ١ځڋ ټڋ ٴؿاـڌٻ NGTفؼڄ ڂ Bypassؼچبپ ـا

ڄ ٴڃاـي ټب ڌٯ ڂ١ڍز دبسڃٸڃلڌٯ ؼاڅ ثبڍٻ ټطٷ ـوبڀؽپ ٤ؿا ـا اڀشػبة ټڋ ځڍٻ.ثڅ اڌځٱڅ دبڊ ؼوشٵب

ثڅ زڅ ىبڀڋ س٥ؿڌډ ـڂؼڄ اڊ ؼاؼڄ ټڋ ڃؼ ؟ ثفاڊ چف ثڍٽبـڊ څ ؼـ ثڍٽبـوشبپ اوز ، اڀشػبة اڂٶ اڌٿ اوز څ اق

ثب ـڌىٯ ٩٠ڃڀز ٽشف اوز ڂ ؼوشٵبڄ ٴڃاـي ثڍٽبـ اوش٩بؼڄ ڃؼ، اڌٿ ڀڃ س٥ؿڌڅ غڍٹڋ جڍ١ڋ سف ، ٨ڍكڌڃٸڃلڌٯ سف ،

integrity ـڂؼڄ ثب اڌٿ ـڂي ثڍشف ض٩ ټڋ ڃؼ ، اټب ڂا١٬ڍز اڌٿ اوز څ چٽڍڅ ټب ڀٽڋ سڃاڀڍٻ اق س٥ؿڌډ ـڂؼڄ اڊ

ؼاـڌٻ. contraindicationاوش٩بؼڄ ځڍٻ ڂ ؼـ خبچبڌڋ

Relative contraindications

Severe necrotizing or hemorrhagic pancreatitis

distal high-output enterocutaneous fistulae

Hypotension with significant inotropicsupport

GI ischemia

Partial bowel obstruction

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، ڃٮ $ ڃڋ څ high output entrocutaneous، ٨ڍىشڃٶ ځشفاڀؽڌٱبوڍڃپ چب ڊ ڀىجڋ بټٷ: دبڀٱفاسڍز ؽڌؽ

ثفاڊ ثڍٽبـ اڀدبٺ ؼاؼڄ اڌٻ# ، اڌځڃسفڂح supportثڅ ضؽڊ ؽڌؽ اوز څ ټڍكاپ قڌبؼڊ ؼاـڂڊ اڌځڃسفڂح ڌب ثڅ چف ضبٶ

ټڋ ثبځؽ.ؼوشٵبڄ ٴڃاـي ڀىجڋڂ ؼـ ڀڇبڌز اڀىؽاؼ ؼوشٵبڄ ٴڃاـي اڌىٱٽڋ

Contraindications

Diffuse peritonitis

Complete bowel obstruction

Paralytic ileus

Intractable vomiting or diarrhea

Severe malabsorption

Severe GI bleed

Inability to access the GI tract

ځشف اڀؽڌٱبوڍڃپ چبڊ ټٹ٫: دفڌشڃڀڍز چبڊ ڂوڍ ، اڀىؽاؼ بټٷ ؼوشٵبڄ ٴڃاـي $سڃټڃـڊ څ بټال ـؽ فؼڄ ڂ

ـڂؼڄ ـا ثىشڅ# ، اڌٹئڃن ، اوش٩فا٢ غڍٹڋ ؽڌؽ ڌب اوڇبٶ غڍٹڋ ؽڌؽ ، وڃءخؿة غڍٹڋ ؽڌؽ $ث١ڋ اق ثڍٽبـاپ وڃء

ڍر خؿثڋ ڀؽاـڀؽ ڂ ثڍٽبـاپ ثىڍبـ بٱشڍٱڋ چىشځؽ.# ، خؿثبپ ث٭ؽـڊ ؽڌؽ اوز څ چفز٭ؽـ ٤ؿا ثڅ آڀڇب ؼاؼڄ ڃؼ چ

GI bleeding ڂټڃاـؼ ؽڌؽrest ؼوشٵبڄ ڂ ٠ؽٺ ؼوشفوڋ ثڅ ڌٻاخبقڈ س٥ؿڌډ ـڂؼڄ اڊ ڀؽاـڅ ؼوشٵبڄ ٴڃاـي

$ؼالڌٹڋ ټبڀځؽ ٩٠ڃڀز ڌب خفاضڋ#. ٴڃاـي

اق زڅ فڌ٫ ثبڌؽ ثڅ ثڍٽبـ ٤ؿا ثفوبڀڍٻ ؟

Route of Administration

PO

NG

Ostomy

PEG

اوز . اٴف ثڍٽبـ چڃڍبـ اوز ڂ ؼوشٵبڄ ٴڃاـي وبٸٻ اوز ، ثڇشفڌٿ بـ اڌٿ اوز څ غڃؼي فڂ POي اڂٶ ـڂ

ثڅ ٤ؿا غڃـؼپ ځؽ ، ضؽا٬ٷ ٨بڌؽڄ اڊ څ ؼاـؼ ٸؿر خڃڌؽپ اوز څ اثف ـڂاڀڋ ثبالڌڋ ؼاـؼ .

اوز څ ؼـ ڃـ ټب غڍٹڋ بڌ اوز . NG tubeـڂي ث١ؽڊ

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Route of Administration

PEGڂ ؼـ ڀڇبڌز ـڂي چبڌڋ ټثٷ اوز jejenostomyڂ gastrostomy بټٷ OStomyـڂي ؼڌٵف

(pericutaneous endoscopic gastrostomy) .

NG

Preferred for short-term (<6wk)

In patients without obstruction of nasal, pharyngeal, esophageal, and gastric passages

ADR: mucosal trauma of nasopharynx, perforation, pharyngitis, sinusitis, otitismedia, and LES incompetence

Radiographic confirmation of tube placement is mandatory

: NGـڂي

څ ؼـ آپ ټطٷ ڂـڂؼ ٤ؿا اق ثڍځڋ ڂ ټطٷ غفڂج آپ ټ١ؽڄ اوز. ؼـ اڌٿ ـڂي ثػڋ اق ٸڃٸډ ٴڃاـي ـا ثؽٸڍٷ ټٱٹڋ

ټڋ ځڍٻ. Bypassڂخڃؼ ؼاشڅ

زڅ قټبڀڋ ڀٽڋ سڃاپ اق اڌٿ ـڂي اوش٩بؼڄ فؼ؟

چځٵبټڋ څ ؼـ غفڂخڋ ټ١ؽڄ سڃټڃـڊ ؼاـڌٻ ڂ ثڍٽبـ ؼزبـ ټٱٹڋ اوز ڂ ٤ؿا اق آپ ټطٷ ڀٽڋ سڃاڀؽ ٠جڃـ ځؽ .

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ىز ڂ اڀدبٺ ڀٽڋ ؼـ ڃـ ټب ټفوڃٺ ڀڍ Nasojejenalڂ Nasodeudenalـڂي چبڌڋ ڀڍف اوش٩بؼڄ اق ٸڃٸڅ چبڊ

اوز څ ثڅ ؼڂ ـڂي اڀدبٺ ټڋ ڃؼ؛ ڌب اق Jejenostomyڂ Gastrostomyڃؼ. ـڂي چبڊ ؼڌٵفڊ څ بڌ اوز

ڂ ثفاڌ ٸڃٸڅ ٴؿاـڊ ټڋ ڃؼ ڂ ڌب اق فڌ٫ اڀؽڂوٱڃدڍٯ ، ثڅ اڌٿ ١ځڋ ثڍٽبـ بټال ثڍڇڃي ټڋ ڃؼ فڌ٫ خفاضڋ ڌ

ڀڃـ اڀؽڂوٱڃح ـا ثڅ وٽز غبـج ټڋ سبثبڀځؽ ، ثب ؼڌؽپ ڀڃـ ـڂڊ فڌ٫ څ ڌٯ اڀؽڂوٱڃح ڂاـؼ ټ١ؽڄ ثڍٽبـ ټڋ ځځؽ ڂ

ٴؿاـڊ ټڋ ڃؼ. اڌٿ PEGدڃوز ڂ اٽڍځبپ اق ټطٷ ټ١ؽڄ اق چٽبڀدب ڂ ثؽڂپ ڀڍبق ثڅ ثڍڇڃڋ ٠ٽڃټڋ وڃـاظ ؽڄ ڂ

ـڂي ڀىجز ثڅ ـڂي خفاضڋ څ ثڍٽبـ ٱٽ بټٷ ثبق ټڋ ڃؼ، غڍٹڋ وبؼڄ سف اوز ، قڂؼسف اڀدبٺ ټڋ ڃؼ ڂ ٴ٩شڅ

٨ف٬ڋ ڀٽڋ ځؽ . $ثفاڊ ټب اڀدبٺ Mortalityچبڊ ٽشفڊ ټڋ سڃاڀؽ ؼاشڅ ثبؽ اټب اق ٸطب Complicationڃؼ ټڋ

چف ؼڂ اټٱبڀذؿڌف اوز#

Which route?

Anticipated duration of tube feeding

Disrupted region or process in the GI tract

Risk of aspiration

ؽاټڍٯ اق اڌٿ ـاچڇب اڀشػبة ټڋ ڃؼ:

وز ثڍٽبـ ـا ـڂڊ س٥ؿڌڅ ثٵؿاـڌٻ ، ټثال ثڅ زځؽ ٨بشڃـ ټػشٹ٧ ثبڌؽ سڃخڅ ؼاشڅ ثبڍٻ ، اڂٶ اڌځٱڅ زڅ ټؽسڋ ٬فاـ ا

ثڅ GI functionس٥ؿڌڅ ڂ اقآپ ـڂق ثىشفڊ ؽپ ثڍٽبـوشبپ ـا سفٮ ځؽ ڂ ث١ؽ 5-4ثڍٽبـڊ څ ٬فاـ اوز ث١ؽ اق

ـا اڀدبٺ ؼچڍٻ ، اټب ثڍٽبـڊ څ س٥ؿڌڅ بـ NGtubeاڌٿ ثڍٽبـ ټڋ سڃاپ غڍٹڋ ڃسبڄ ټؽر ثب ؼـثف ټڋ ٴفؼؼ ،ضبٸز ٠بؼڊ

چبڊ خڃڌؽپ ڂ ثٹ١ڍؽڀ ثڅ ضبٸز ٠بؼڊ ثبق ٴفؼؼ ڂ ضؽن ټڋ Functionڅ ڌٯ ؼٸڍٷ ڀڃـڂٸڃلڌٯ ٬فاـ ڀڍىز ټڋ ؼاڀڍٻ ث

ټڋ ـڂڌٻ. Ostomyټبڄ ؼـ اڌٿ فاڌ غڃاچؽ ثڃؼ ، اق چٽبپ اثشؽا وفا٢ 1قڀڍٻ ثڍٽبـ ثڍ اق

زبـ ټٱٷ ؽڄ ـاڄ ـا ڀٱشډ ټڇٻ ؼڌٵف اڌٿ اوز څ دبڊ ؼوشٵبڄ ٴڃاـي ؼزبـ ټٱٷ ؽڄ اوز ، ثىشڅ ثڅ اڌځٱڅ دب ؼ

ٽڋ سڃاڀڍٻ اق ټ١ؽڄ اوش٩بؼڄ ڀڅ اڀشػبة ټڋ ځڍٻ ، ټثال اٴف ټ١ؽڈ ثڍٽبـ ؼـ دڍٹڃـ ؼزبـ ټٱٷ اوز ڌب سڃټڃـڊ ؼاـڌٻ

اڀشػبة ټڋ ځڍٻ ، ـڌىٯ آوذڍفاوڍڃپ ـاڄ س٥ؿڌڅ ـا ځڍٻ . ټڃـؼ آغفڊ څ ثف اوبن آپ jejenostomyثبڌؽ ځڍٻ ،

چڇبڊ چڃاڌڋ اي اق وص چڃڍبـڊ ثڍٽبـ سڃاپ ض٩ ـاشفڊ ؽڄ ثؽٸڍٷ بچثى ICUاوز ، ؼـ ثڍٽبـڊ څ ؼـ

آوذڍفاوڍڃپ ـا ڀؽاـؼ. ؼـ اڌٿ ثڍٽبـ ثڇشف اوز سب آڀدب څ ټڋ سڃاپ اق ټ١ؽڄ ٽشف اوش٩بؼڄ ڃؼ ڌب ـڂي چبڌڋ اوش٩بؼڄ

ځڍٻ څ ټ١ؽڄ غڍٹڋ دف ڀڃؼ ، دف ثڃؼپ ټ١ؽڄ ثب٠ث ثبال آټؽپ ٤ؿا ڂ آوذڍفاوڍڃپ ټڋ ڃؼ.

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NG tube ٽشف اق ڌٯ ټبڄ ڂ ڀڍٻ ټڋ سڃاڀڍٻ اق ټؽر قټبپ : ثفاڊNG اوش٩بؼڄ ځڍٻ ، ف اڌٿ اوز څ ؼـ ټىڍفڊ

ڂاـؼ ټڋ ڃؼ ، اڀىؽاؼڊ ڂخڃؼ ڀؽاشڅ ثبؽ ڂ ټ١ؽڄ چٻ ؼزبـ ټٱٹڋ ڀجبؽ ، ڌ١ځڋ ٸڃٸڅ ٴڃاـي اق خبڌڋ څ NGڅ

ټب ٤ؿا ـا ڂاـؼ ټڋ ځڍٻ سب اڀشڇبڊ ټ١ؽڄ ثبڌؽ وبٸٻ ثبؽ.

: NG ٠ڃاـ

ثڅ ټڍكاپ ڂ ټٽٱٿ اوز ټڋ ثڍځؽټػب ثڍځڋ ڂ دز ضٹ٫ آوڍت ـا بـ ټڋ ٴؿاـڀؽ ڌٯ ټ٭ؽاـ NGبڌ سفڌٿ : ټڃ١٬ڋ څ

اڌدبؼ وڍځڃقڌز ڃالڀڋ ټؽر ثٽبڀؽ ټٽٱٿ اوز اڌٿ ټبڀؽٴبـڊ ؼـ ټىڍف NGٻ غڃڀفڌكڊ ځؽ څ غڍٹڋ ټڇٻ ڀڍىز. اٴف

ثڃخڃؼ ټڋ آڌؽ ڂ ٤ؿا Incompetenceؼـ ڀشڍدڅ ٸڃٸڅ ٠جڃـ فؼڄ ڂچٽڍڅ ڌٯ LESاڌٿ اوز څ اق ڀٽبڌؽ ، ټٱٷ ؼڌٵف

اق آڀدب ټڋ سڃاڀؽ ثڅ ثبال ثفٴشڅ ڂ آوذڍفڄ ڃؼ .

ؼـ ټ١ؽڄ ثڍٽبـ ٬فاـ ؼاـؼ ، اڌٿ ٸڃٸڅ ث١ؽ اق ٸڃٸڅ ٴؿاـڊ ضشٽب ثبڌؽ اق فڌ٫ ـاؼڌڃ ٴفا٨ڋ ٠ٱه ثٵڍفڌٻ څ ټٽئٿ ثبڍٻ

ڂاـؼ ثفڂڀ فؼڄ ثبڍٻ ڂ ثب ڌٱجبـ ٤ؿا ؼاؼپ ثڍٽبـ ـا اق ثڍٿ ثجفڌٻ. غف ڂخڃؼ ؼاـؼ څ ثدبڊ ټ١ؽڄ ثڍٽبـ ٸڃٸڅ ـا

ټڋ ـڂڌٻ؟ ostomyزڅ قټبڀڋ وفا٢

Ostomies

For long-term (>4wk)

Open surgery, laparoscopy, or percutaneously

NGثفڂڌٻ . اٴف چٻ اڂٶ Ostomyاٴف اق اثشؽا ثؽاڀڍٻ څ ټؽر س٥ؿڌڅ ؼاؼپ ڃالڀڋ اوز ، ثڇشف اوز اق چٽبپ اڂٶ وفا٢

خفاضڋ ، الدبـاوٱڃدڋ ڂ ټثٷ خبڌٵكڌٿ ټڋ ځڍٻ ثب ـڂڇبڌڋ ostomyـا ثب NGڄ ثڃؼڄ ڂ ضبال ڃالڀڋ ؽ

دفڃسبڀئڃن.

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Site of Delivery

Preferred site: stomach

Transpyloric feeding: when gastric dysfunction or disease is present, when risk of aspiration is high, or for early post-OP feeding when gastric emptying may be impaired

وبڌز ڂـڂؼ ٤ؿا:

ثڇشفڌٿ ضبٸز اڌٿ اوز څ ؼـ ټ١ؽڄ ثفڌكؼ ، قڌفا ټ١ؽڄ ټطٷ ٨ڍكڌڃٸڃلڌٯ اڀجبـ ؽپ ٤ؿا وز ڂ ټب ټڋ سڃاڀڍٻ ڌٯ ضدٻ

ڀٵڇؽاـڌٻ ڂ چٽسځڍٿ ا٠ٽبٶ ٨ڍكڌڃٸڃلڌٱڋ ڀڍف اق ثڍٿ ثفؼپ ثبشفڊ چب ثػبف ضبٸز اوڍؽڌشڅ ڂ غڃثڋ اق ٤ؿا ـا ؼـ آڀدب

ټػٹڃ فؼپ ٤ؿا ثب ڌٱىفڊ آڀكڌٻ چب ـا اڀدبٺ ټڋ ؼچؽ.

دڍٹڃـڌٯ ٠جڃـ ؼاؼڄ ڂ سػٹڍڅ ځڍٻ.قټبڀڋ اڌٿ بـ اڌٿ اوز څ اق ټ١ؽڄ ڂ دڍٹڃـ ٠جڃـ ځڍٻ ڂ ٤ؿا ـا سفاڀه ڊوبڌز ث١ؽ

ـ ټ١ؽڄ ڌٯ ڂ١ڍز دبسڃٸڃلڌٯ ؼاشڅ ثبڍٻ ، ضؽن ثكڀڍٻ ـڌىٯ آوذڍفاوڍڃپ ثبالوز ڂ ڌب قټبڀڍٱڅ ـا ټڋ ځڍٻ څ ؼ

ثڍٽبـ ڌٯ خفاضڋ ڂوڍ ٱٽڋ ؼاشڅ څ ؼـ اڌٿ ثڍٽبـاپ ضفبر ټ١ؽڄ سب ټؽسڋ ؼزبـ اغشالٶ اوز. ؼـ چف ڌٯ اق اڌٿ

ٿ ـڂي اڌٿ اوز څ ڂ٬شڋ ڂاـؼ ـڂؼڄ فاڌ اق دڍٹڃـ ٠جڃـ ټڋ ځڍٻ ڂ ٤ؿا ـا ؼـ للڀڃٺ سػٹڍڅ ټڋ ځڍٻ. اٱبٶ اڌ

ؽڌٻ ، چٽبڀځؽ ټ١ؽڄ، ضدٻ غڃثڋ ـا ڀٽڋ سڃاڀڍٻ ثؽچڍٻ ڂ ټدجڃـ چىشڍٻ اق ضدٻ چبڊ ٻ ڂ ثشؽـڌح اوش٩بؼڄ ځڍٻ.

: Enteral feedingاڀڃا

اڀفلڊ ؼاـؼ څ اال ث١ځڃاپ ٴبڂال ؼـ ڀف ڀٽڋ ٴڍفڌٻ. 0.4kcal/mlٴبڂالثڍٽبـوشبپ ، زڍكڊ ؼـ ضؽڂؼ -

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Formulas

Polymeric Fiber content

Calorie density

Protein content

Oligomeric

Specialized Renal failure

Hepatic failure

Critically ill

Pulmonary disease

Immune modulting

Modular

س٭ىڍٻ ثځؽڊ ٨فټڃٶ چب:

. ڀڃ ؼڂٺ اوز ڌٯ قڀدڍفڈ بټٷ دفڂسئڍٿ ڂآپ اوز دفڂسئڍٿ وبٸٻ ټڃخڃؼ ؼـ ټفڌٯ ڌ١ځڋ دفڂسئڍٿ٨فټڃٶ چبڊ دٹڋ

اٸڍٵڃټفڌٯ چىشځؽ ، ؼـ اڌٿ ٨فټڃٶ چب قڀدڍفڈ ثكـٲ آټڍځڃ اوڍؽ ـا ثب ـڂي چبڌڋ ڃسبڄ فؼڄ اڌٻ ڂ ټثال ٨فټڃٶ چبڊ

٨فاڂـؼڄ چب اڌٿ ڋ ٽٯ ټڋ ځځؽ. اٱبٶسجؽڌٷ ثڅ ؼڊ دذشڍؽ ڌب سفڊ دذشڍؽ فؼڄ اڌٻ . اڌځٱبـ اق ٸطب خؿة ؼـ خبچبڊ غب

ڂ ثب ثبال ـ٨شٿ اوٽڃالـڌشڅ ، سػٹڍڅ ټ١ؽڄ ثڅ سأغڍف ټڋ ا٨شؽ ، ٤ؿا قټبپ ڃالڀڋ ـا ثبال ټڋ ثفڀؽاوز څ اوٽڃالـڌشڅ اڌٿ

ـڌىٯ آوذڍفاوڍڃپ ثبال ټڋ ـڂؼ. ثځبثفاڌٿ سطٽٷ ٴڃاـڋ ثڍٽبـ ثفاڊ س٥ؿڌڅ سفڊ ؼـ ټ١ؽڄ ثب٬ڋ ټڋ ټبڀؽ ڂ ؼـ ڀڇبڌز

چبڊ ث١ؽڊ ڂ ضدٻ چبڊ ثڍشف دبڌڍٿ ټڋ آڌؽ . اٱبٶ ؼڌٵف آپ اڌځىز څ ٨فاڂـؼڄ ڂ٬شڋ اوٽڃالـڌشډ ثبالسفڊ ؼاشڅ

ـ اڌځٵڃڀڅ ؼاـؼ ڂ ؼـ ڀشڍدڅ ـڌىٯ اوڇبٶ چبڊ اوٽڃسڍٯ ؼټڋ ثبؽ ثڅ ـڂؼڄ څ ټڋ ـوؽ آة ثڍشفڊ ؼـ غڃؼ ڀٵڅ

ټڃاـؼ ثبال ټڋ ـڂؼ.

اق دفڂسئڍٿ ، زفثڋ ڂ فثڃچڍؽـار ٯ ٴبڂال بټٷ ڂ ټدٽڃ٠څ اڊچىشځؽ. ڌ١ځڋ ټب ڌ ٨Modularفټڃٶ آغف ٨فټڃٸڇبڊ

MCT غڃاچڍٻ ټ٭ؽاـ ثڍشفڊ زفثڋ ثؽچڍٻ،ټڋ غشڅ ؽڄ اڀؽ ، ټثال ؼـ ڌٯ ثڍٽبـؼـ ټؽڂالـ اڌٿ اخكا سٯ سٯ وب . ؼاـڌٻ

oil (medium chain triglyceride)، چبڊ غبڋ چٻ ثفاڊ ثڍٽبـڊ چبڊ غب وڍڃپ٨فټڃال ـا چٻ خؽاٴبڀڅ ؼاـڌٻ

٨فټڃٶ غبڋ ـا سڇڍڅ فؼڄ اڀؽ څ سڃڍص ؼاؼڄ غڃاچؽ ؽ. Renal failure ؼـټثال . ؼاـڌٻ

فزمول هبی پلی مزیک:

كاپ دفڂسئڍٿڂټڍ، ټڍكاپ بٸفڊ ټڍكاپ ٨ڍجف :٨فټڃٶ چبڊ دٹڋ ټفڌٯ اق زځؽ خڇز س٭ىڍٻ ثځؽڊ ټڋ ڃڀؽ

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Fiber content

•1–9 g/1,000 kcalLow

•9.1–13.9 g/1,000 kcalModerate

•>14 g /1,000 kcalHigh

س٭ىڍٻ ټڋ ڃڀؽ. low fiber ,moderate fiber , high fiberثف اوبن ټڍكاپ ٨ڍجف ثڅ

ؼـ highٴفٺ 14ڂ ثبالڊ moderateٴفٺ ؼاشڅ ثبځؽ low ،14-9ٴفٺ ٨ڍجف ؼاشڅ ثبځؽ 9اٴف kcal 1000ؼـ چف

ڀف ٴف٨شڅ ټڋ ڃڀؽ.

Fiber advantages

Increased fecal bulk

↓ transit time in patients susceptible to constipation

↑ transit time in patients with diarrhea

Reduction of serum cholesterol

Improved glycemic control in diabetics

٨ڍجفزڅ بـ ټڋ ځؽ؟

ضدٻ ټؽ٨ڃ ـا ا٨كاڌ ټڋ ؼچؽ .1

قټبپ ٠جڃـ اق ؼوشٵبڄ ٴڃاـي ـا سځڍٻ ټڋ ځؽ ؼـ ا٨فاؼڊ څ قټبپ قڌبؼ اوز آڀفا ڃسبڄ ټڋ ځؽ ڂ ثبٸ١ٱه. .2

ضفبر ٴڃاـي اوز. Modulatorثځبثفاڌٿ ڌٯ

ثڅ 14gr. ڌ١ځڋ ٨فؼ ضؽا٬ٷ ثبڌؽ ڌؽڄ ټڋ ڃؼؼ high fiberثب ٨فاڂـؼڄ چبڊ څٹىشفڂٶ غڃپ ـا ٻ ټڋ ځؽ. .3

اڀفلڊ ٨ڍجف ټف٦ ځؽ څ ٨ڃائؽ ټشبثڃٸڍٱڋ اي ـا ثجڍځؽ. 1000kcalاقاڊ چف

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غڃپـا ثڇشف ځؽ ثڅ اڌځڃـر څ ڂ٬شڋ فثڃچڍؽـار ڌب ٬ځؽ ټف٦ ټڋ ڃؼ ، ٬ځؽ ٬ځؽ ٨ڍجف ثبال ټڋ سڃاڀؽ ځشفٶ .4

.آپ دڍٯ ـا ټڋ ٴڍفؼ ثڅ ڌٯ دڍٯ ټڋ ـوؽ ڂ ث١ؽ دبڌڍٿ ټڋ آڌؽ ، ٨ڍجف خٹڃڊ

Fiber source

Insoluble fiber: changes in fecal bulk and transit time

Soluble fiber: responsible for effects on cholesterol and glycemic control

Soluble fibers: pectin, psyllium, and certain gums

Soluble fibers are fermented to short-chain FAs; they stimulate colonic blood flow, enhance fluid and electrolyte absorption, and provide a trophiceffect in the colon.

آڀڇبڌڋ چىشځؽ څ ؼـ soluble$اٸجشڅ چفؼڂ ٤ڍف ټطٹڃٶ اڀؽ# . ٨ڍجف چبڊ insolubleڂ solubleؼڂ ڀڃ ٨ڍجف ؼاـڌٻ ،

چب ټڋ ثڍځڍؽ . ثڃـ ٹڋ ٨ڍجف چبڌڋ څ ڂ٬شڋ ؼـ آة ټڋ ـڌكڌٻ ڌٯ ٸ١بثڋ ؼڂـ غڃؼ gumدٱشڍٿ ، دىڍٹڍڃٺ ڂ ث١ڋ

Insolubleغڃاڀؽڄ ټڋ ڃڀؽ. اڌٿ ٨ڍجف چب ټىئڃٶ ټكڌز چبڊ ټشبثڃٸڍٯ چىشځؽ اټب ٨ڍجف چبڊ solubleاڌدبؼ ټڋ ځځؽ

بـ ا٨كاڌ ضدٻ ټؽ٨ڃ ڂ سځڍٻ قټبپ ٠جڃـ اق ؼوشٵبڄ ٴڃاـي ـا اڀدبٺ ټڋ ؼچځؽ.

ثبشفڊ چبڌڋ سػٽڍف ټڋ اڌٿ اوز څ اڌځڇب ڂ٬شڋ ثڅ اڀشڇبڊ ؼوشٵبڄ ٴڃاـي ـوڍؽڀؽسڃو ٨solubleڍجف چبڊ ټكڌز

خؿة آة ټڋ ڌبثؽ ثځبثفاڌٿ ـڌىٯ اڌىٱٽڋ ڄ ـا ٻ ټڋ ځځؽ ڂ ڃڀؽ ڂ ؼـ اثف آپ خفڌبپ غڃپ ؼوشٵبڄ ٴڃاـي ا٨كاڌ

آپ ڂ integrityـؽ ـڂؼڄ ثڅ ض٩ ڌٯ اثف سفڂ٨ڍٯ ـڂڊ ـڂؼڄ ؼاـڀؽ ، ڌ١ځڋ ثب.ڂ اٸٱشفڂٸڍز چب ـا ثڇجڃؼ ټڋ ثػځؽ

ض٩ والټز آپ ٽٯ ټڋ ځځؽ.

ټڋ critically illٽٯ ڀٽڋ ځؽ ثځبثفاڌٿ ٨ڍجف ـا ثفاڊ ثڍٽبـ ٤ڍف ٠ICUٽٷ ؼڌؽڄ ؽڄ اوز ؼاؼپ ٨ڍجف ثڅ ثڍٽبـ ؼـ

.ٴؿاـڌٻ

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Fiber

Some patients on short-term EN without GI pathology with altered stool consistency may benefit from fiber.

The effect of fiber on patients with bowel pathology is less clear.

Fiber may be detrimental in the hypotensivepatient with subclinical ischemia.

ؼـ ثڍٽبـاڀڋ څ ـڂؼڈ وبٸٻ ؼاشڅ ثبځؽ ٴ٩شڍٻ څ ټكڌز چبڊ غڍٹڋ غڃثڋ چىز ڂٸڋ ؼـ ثڍٽبـڊ څ ـڂؼڈ ڀبوبٸٻ ؼاـؼ

ؼوشٵبڄ ٴڃاـي ثڅ چٻ ـڌػشڅ ثبؽ ڀٽڋ ؼاڀڍٻ څ آڌب اٴف ٨ڍجف ثؽچڍٻ ٽٱڋ ثڅ ثڍٽبـ ټڋ ڃؼ ڌب ڀڅ ڂ integrityڂ

controversy ؼـټبپ ڂخڃؼ ؼاـؼ ڂ ټڃـؼڊ څ چڍسٵبڄ ٨ڍجف ڀٽڋ ؼچڍٻ ، ثڍٽبـڊ اوز څ ؼـ ڃٮ اوز ڂ سطز

اڌځڃسفڂح ٬فاـ ؼاـؼ زڃپ ثفاڊ اڌٿ ثڍٽبـ ٨ڍجف ټڋ سڃاڀؽ ټف ثبؽ.

Fiber: ADR

Increase formula viscosity

Increased gas production

Abdominal discomfort

Bezoar formation

اٱبالر ٨ڍجف :

ڀبقٮ اڌٿ ٨فټڃالوڍڃپ NGڂڌىٱڃقڌشډ ٨فاڂـؼڄ ـا غڍٹڋ ثبال ټڋ ثفؼ ، اٱبٶ آپ اڌځىز څ ټب ثبڌؽ اق فڌ٫ ڌٯ ٸڃٸډ

ـا ٠جڃـ ؼچڍٻ ڂ٬شڋ ڂڌىٱڃقڌشڅ ثبال ټڋ ـڂؼ ٴبڂال فؼپ ټٱٷ ټڋ ڃؼ ٠الڂڄ ثف اڌٿ غڃؼ ڂڌىٱڃقڌشډ ثبال ټڋ سڃاڀؽ

س١ڃڌ ځڍٻ.ىؽاؼ ٸڃٸڅ ڃؼ ڂ ټب ټدجڃـ ثبڍٻ ٸڃٸڅ خت اڀڃټ

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ټٱٷ ؼڌٵف اڌٿ اوز څ ڂ٬شڋ ٨ڍجف قڌبؼڊ اوش٩بؼڄ ڃؼ ڌٱىفڊ ؼـؼ چبڊ ټجڇٻ ؼـ ث١ڋ اق ا٨فاؼ ؼڌؽڄ ټڋ ڃؼڂ ڌب

-critically ill ،intraټڋ سڃاڀؽ آڀ٭ؽـ ؽڌؽ ثبؽ څ ؼـ ڌٯ ثڍٽبـ ٽبـاپ ټڋ سڃاڀځؽ ؼزبـ ڀ٩ع ڃڀؽ څ اڌځٱڅ ثڍ

abdominal pressure .آڀ٭ؽـ قڌبؼ ڃؼ څ ٨بـ ثڅ ؼڌب٨فاٴٻ آڂـؼڄ ڂټٱالر قڌبؼسفڊ ثفاڊ ثڍٽبـ اڌدبؼ ڃؼ

gastroثؽٸڍٷ ؼڌبثز ؼزبـ $ټىٿ اوز ڌب ٨فؼ دفڌىشبٸشڍىٻ غڃثڋ ؼـ ـڂؼڄ ڀؽاـؼ ټٱٷ ؼڌٵف اڌٿ اوز څ اٴف

paresis سدٽ دڍؽا فؼڄ ڂ سٱڍٷ ڌٯ خىٻ غبـخڋ ٨ڍجف ټڋ سڃاڀؽ #ؽڄ ڂ ضفبر ؼوشٵبڄ ٴڃاـي ټځبوجڋ ڀؽاـؼ

.ثؽچؽ ڂ ټځدف ثڅ اڀىؽاؼ بټٷ ؼوشٵبڄ ٴڃاـي ڃؼ

Caloric Density

Caloric Density

Increased caloric density

Increased formula osmolality

Reduced gastric emptying

Feeding intolerance

ټڍكاپ بٸفڊ ٨فټڃٶ چبڊ دٹڋ ټفڌٯ:

س٭ىڍٻ ټڋ standard (1-1.2 kcal/ml), moderate (1.5kcal/ml) ,high (1.8-2 kcal/ml)ثف اوبن بٸفڊ ثڅ

ڃڀؽ.

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Fresubin ڀڃ HP اڀفلڊ اق ڀڃ ؼڂٺ اوز ڂoriginal اوشبڀؽاـؼ. اق ڀڃ

ٸڍشف ؼـ ـڂق ثڅ ڂڊ ٤ؿا ثؽچڍٻ څ اټٱبپ 6-5ٴبڂال ټ١فڂ٦ ثڍٽبـوشبپ اڀفلڊ بټٷ ثڅ ثڍٽبـ ثؽچڍٻ ثبڌؽ اٴف ثػڃاچڍٻ ثب

دؿڌف ڀڍىز.

ڀبـوبڌڋ ٹڍڃڊ ؼاـؼ ڂ ټدجڃـڌٻ ټبڌ١بر ثڍٽبـ ـا ٻ ټثال ثڍٽبـقڌبؼ ثؽچڍث١ڋ ڂ٬شڇب ټب ڀٽڍشڃاڀڍٻ ثڅ ثڍٽبـ ضدٻ

caloricټطؽڂؼ ځڍٻ ، ؼـ اڌٿ ټڃا٬ وفا٢ ٨فاڂـؼڄ چبڌڋ ټڋ ـڂڌٻ څ ؼـ ضدٻ ٻ اڀفلڊ ثڍشفڊ ؼاـڀؽ ؼـ ڂا٬

dense دڃؼـ چىشځؽ .calshake 1.8ثبkcal/ml اڀفلڊCaloric dense ڃـ اڌىز څ ټب ١٨ال ؼـ سفڌٿ ٨فاڂـؼڄ

calorie densityثڍشفڌٿ ټڍكاپ اڀفلڊ ؼـ ٽشفڌٿ ضدٻ ـا ټڋ سڃاڀڍٻ ثب آپ ثؽچڍٻ. ټٱٹڋ څ ثب ا٨كاڌ ؼاـڌٻ ڂ

اڌدبؼ ټڋ ڃؼ اڌٿ اوز څ اوٽڃالـڌشډ ٨فاڂـؼڄ چٻ ثبال ټڋ ـڂؼ ، غفڂج ټ١ؽڄ ؼزبـ ټٱٷ ټڋ ڃؼ ڂ ثڍٽبـ ڀىجز ثڅ

ىٯ آوذڍفڄ ؽپ ثبال ټڋ ـڂؼ.ؼـ زځڍٿ فاڌڋ ـڌڂ٨فاڂـؼڄ ٠ؽٺ سطٽٷ دڍؽا ټڋ ځؽ

Protein content

Protein needs increase disproportionately to caloric needs during injury and critical illness.

Protein or Nitrogen Content

٨فټڃٶ چب ثف اوبن ټڍكاپ دفڂسئڍٿ :

Low ڃؼ." اق اڀفلڊ ـوڍؽڄ ثڅ ثڍٽبـ ثب دفڂسئڍٿ سأټڍٿ 9-6اٴف

Standard ڃؼ. دفڂسئڍٿ سأټڍٿ" اڀفلڊ ثب 15-11 اٴف

High ثب دفڂسئڍٿ سأټڍٿ ڃؼ.ڊ اڀفل" 16اٴف ثڍ اق

ڌب وڃغشٵڋ ؽڄ ټب ثبڌؽ ټ٭بؼڌف قڌبؼڊ دفڂسئڍٿ ثڅ ڂڊ ثؽچڍٻ ثځبثفاڌٿ اق sepsis ڌبسطز اوشفن ټشبثڃٸڍٯ اٴف ثڍٽبـ

اوش٩بؼڄ ټڋ ځڍٻ. ڀڍبق چبڊ دفڂسئڍٿ ثڍٽبـ ڀبټشځبوت ثب ڀڍبق چبڊ بٸفڊ ا٨فاؼ ا٨كاڌ دڍؽا ټڋ ځؽ، ټثال ٨فؼڊ Highڀڃ

ثفاثف ؽڄ اټب ټڍكاپ ٬1.5فاـ ٴف٨شڅ ټثال وڃغشٵڋ ، ټڍكاپ اڀفلڊ اي ٨فب ڀىجز ثڅ ضبٸز ٠بؼڊ څ سطز اوشفن

ټڍكاپ ڀڍبق ثڅ دفڂسئڍٿ ڀىجز ثڅ اڀفلڊ ثڍشف ا٨كاڌ ثبؽ، ثفاثف ؽڄ . چفزڅ اوشفن ثڍشف 2ڀڍبق ثڅ دفڂسئڍٿ اي

غڃاچؽ ڌب٨ز.

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Oligomeric Formulas

Predigested, monomeric or chemically defined formulas

Require minimal digestive function

Produce little residue in the colon

For patients with pancreatic insufficiency, reduced mucosal absorption.

Uses: severe pancreatic insufficiency and short bowel syndrome

#:predigested ،monomeric ،chemically defined formula$٨فټڃٸڇبڊ اٸڍٵڃټفڌٯ

ؼـ ڃـ اق اڀڃا اٸڍٵڃټفڌٯ ڂخڃؼ ڀؽاـؼ . اڌځڇب ٨فټڃٶ چبڌڋ چىشځؽ څ قڀدڍفڈ دفڂسئڍځڋ بپ سڃو آڀكڌٻ ٱىشڅ

ٸڋ څ ؽڄ اوز. ټكڌشبپ اڌٿ اوز څ ؼڌٵف ڀڍبق ثڅ اڌځٱڅ ؼوشٵبڄ ٴڃاـي آڀكڌٻ چٽڋ ؼاشڅ ثبؽ ـا ڀؽاـڀؽ . اٱب

ثفاثف ٨فټڃالوڍڃپ ٠بؼڊ ثبؽ. 20چكڌځڅ ټٽٱٿ اوز سب ٴبچڋ ؼاـڀؽ اڌٿ اوز څ ٬ڍٽز غڍٹڋ ثبالڌڋ ؼاـڀؽ

ټكڌز ؼڌٵفبپ اڌٿ اوز څ زڃپ اڌځڇب آټبؼڄ ثفاڊ خؿة چىشځؽ ڂ چٻ ثڃـر بټٷ ؼـ آڀڇب اڀدبٺ ؽڄ وفڌ

اؼڊ ر بټٷ خؿة ټڋ ڃڀؽ. ثفاڊ ا٨فخؿة ټڋ ڃڀؽ ڂ ثب٬ڋ ټبڀؽڄ اڊ ؼـ ؼوشٵبڄ ٴڃاـي ڀٽڋ ٴؿاـڀؽ ڂ ثڃـ

١٨بٸڍز اڀؽڂفڌځڋ غڃثڋ ڀؽاـؼ ڂ ڌب ثڍٽبـ وڃء خؿة قڌبؼڊ ؼاـؼ . اټب قټبڀڋ وفا٢ اڌٿ اوش٩بؼڄ ټڋ ڃؼ څ دبڀٱفان

٨فاڂـؼڄ چب ټڋ ـڂڌٻ څ ٬جٷ اق آپ ڌٯ ٨فاڂـؼڈ ټ١ٽڃٸڋ ثڅ ثڍٽبـ ثڅ چٽفاڄ دبڀٱفاسڍٿ ؼاؼڄ ثبڍٻ ڂ ثڍٽبـټبپ ثبق چٻ

څ ثبؽ .وڃء خؿة ؼاش

Specialized Formulas

Renal failure Essential amino acid enriched

Low protein and electrolytes

Hepatic failure (high BCAA, low AAA)

Stress or critically ill Branched-chain enriched

High nitrogen plus conditionally essential nutrients

Immune modulating

Pulmonary disease

Glucose control

٨فټڃالوڍڃپ چبڊ غب:

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ثفاڊ ڀبـوبڌڋ ٹڍڅ ، جؽ ڂ ... ٨فټڃالوڍڃپ چبڊ غب سڇڍڅ ؽڄ اوز. ټثال ىبڀڋ څ جؽبپ ؼزبـ ټٱٷ اوز ڂ

اوڍؽ چبڊ غڍٹڋ اق ١٨بٸڍز چبڊ ڍٽڍبڌڋ ؼاغٷ جؽ ؼڌٵف اڀدبٺ ڀٽڋ ڃؼ. ټب ثڅ اڌٿ ا٨فاؼ ثڅ ټڍكاپ ثڍشف آټڍځڃ

branched ڂ ؼاـاڊ قڀدڍفڈ خبڀجڋ ڂ ثڅ ټڍكاپ ٽشف آټڍځڃ اوڍؽ چبڊ آـڂټبسڍٯ ټڋ ؼچڍٻ . قڌفا اٴف آټڍځڃ اوڍؽ چبڊ

ټڋ ـڂؼ ڂ ڀڃـڂسفاڀىٽڍشف چبڊ GABAثڅ وٽز سڃٸڍؽ ثڍشف آـڂټبسڍٯ ثڍشف ثڅ ثڍٽبـ ؼاؼڄ ڃؼ ټىڍف چبڊ وځشك

false ب ڂ بچ وص چڃڍبـڊ ٬فاـ ټڋ ٴڍفؼ. چٽډ اڌځڇب ؼـ سئڃـڊ ثڍشفڊ سڃٸڍؽ ټڋ ڃؼ ڂ ثڍٽبـ ؼـ ـڌىٯ ٽ

اټب ؼـ ٠ٽٷ ثڃـ ٠بٺ چڍر خب ثبثز ڀؽڄ څ ؼاؼپ ڀؽوبغشڅ ؽڄ ا اوبنؼـوز اوز ڂ ٨فاڂـؼڄ چب ثف اڌٿ

ـ ٨فټڃالوڍڃپ غب جؽڊ ثفاڊ ڌٯ ثڍٽبـ جؽڊ ټڋ سڃاڀؽ ټ٩ڍؽ ثبؽ ثځبثفاڌٿ ـڂڊ اڌځڇب غڍٹڋ ثطث ڀٽڋ ځڍٻ ؼـ ڃ

چٻ ثىڍبـ ثبالوز. اڌٿ ٨فاڂـؼڄ چب چكڌځڅ ڀڃ ؼڌبثشڍٯ ڂخڃؼ ؼاـؼ. چٻ ٨٭

Administration

Continuous

Cyclic

Intermittent

Bolus

Initiation of feeding

سب اڌځدب ٨فټڃالوڍڃپ چب ـا ثف اوبن فاڌ ثڍٽبـ ، اوشفن ڂ ڀڍبق چبڊ ثڍٽبـ ثڅ اڀفلڊ ڂ دفڂسئڍٿ اڀشػبة فؼڌٻ ،

ثڅ ثڍٽبـ ثؽچڍٻ؟ ٸڃٸڅ ـا چٻ ٴؿاشڍٻ ، ضبال ثڅ زڅ سفسڍجڋ ثبڌؽ اڌٿ س٥ؿڌڅ ـا

وب٠ز ثفاڊ ثڍٽبـ ٴبڂال ڃؼ ، اڌٿ بـ ڀڍبقټځؽ 24ثؽچڍٻ ؛ ڌ١ځڋ ٨فاڂـؼڄ ؼـ ڋ continuousـڂي اڂٶ اڌٿ اوز څ

څ ثفاڊ اڌٿ ٨فاڂـؼڄ چب فاضڋ ؽڄ اوز. اوز چٽبڀځؽ وز وفٺ administration setاوش٩بؼڄ اق ڌٯ دٽخ ڂ ڌٯ

اوز ، اڌٿ ثڍٽبـ ICUڂ ثىشفڊ ؼـ critical illnessثال ثڍٽبـڊ ؼزبـ ڌٯ قټبڀڋ اق اڌٿ ـڂي اوش٩بؼڄ ټڋ ځڍٻ څ ټ

سطٽٷ ٴڃاـڋ غڃثڋ ڀؽاـؼ ڂ اٴف ټب ڌٱؽ١٨څ ټ١ؽڄ اي ـا دف ځڍٻ چٻ ـڌىٯ آوذڍفڄ ؽپ ثبال ټڋ ـڂؼ چٻ اڌځٱڅ اڌٿ

ٻ س٥ؿڌڅ ـا rateوب٠ز ثب ڌٯ 24ثؽچڍٻ ؼـ ڋ Bolus ټطٹڃٶ س٥ؿڌڅ ـا ټ١ؽڄ سػٹڍڅ ڀػڃاچؽ ؽ . ده ثدبڊ اڌځٱڅ

اڀدبٺ ټڋ ؼچڍٻ.

:cyclicس٥ؿڌډ

ـڂي ٴ٩شڅ ټڋ ڃؼ . قټبڀڋ اق اڌٿ cyclicوب٠ز ثبؽ ثڅ آپ 24چفٴبڄ ټب س٥ؿڌڅ ـا ثڃـ ټؽاڂٺ ثؽچڍٻ اټب ٽشف اق

ثبـ ٴبڂال ټڋ ڃؼ اټب چځڃق ال٤ف 5-4ؼاـؼ ڂ غڃؼي ؼـ ڃٶ ـڂق ostomyاوش٩بؼڄ ټڋ ځڍٻ څ ټثال ثڍٽبـڊ ڌٯ

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ثڍٽبـ ؼـ ڃٶ ت څ غڃاة اوز ٴبڂال غڃؼثػڃؼ ثفاڊ cyclicس٥ؿڌڅ اي ثڅ ټڍكاپ ب٨ڋ ثبال ڀف٨شڅ . ؼـ ـڂي ټبڀؽڄ ڂ

اڀدبٺ ټڋ ڃؼ.

: bolusڂ intermittent س٥ؿڌډ

1ؼ٬ڍ٭څ $سب 20ثبـ ثڅ ثڍٽبـ ٤ؿاـوبڀڋ ځڍٻ . ٨ف٬بپ اڌٿ اوز څ اٴف ؼاؼپ ٤ؿا ثڍ اق 3ڌ١ځڋ اڌځٱڅ ټثال ؼـ ڃٶ ـڂق

غڃاڀؽڄ ټڋ ڃؼ. اڌٿ ؼڂ ضبٸز آغف bolusؼ٬ڍ٭څ ڃٶ ثٱؽ 20ڂ اٴف ٽشف اق intermittent# ڃٶ ثٱؽ وب٠ز

ثب ضدٻ ثبال ـا ٨feedingڍكڌڃٸڃلڌٯ سفڌٿ ـڂي چب چىشځؽ . اٱبٸبپ اڌٿ اوز څ ثڍٽبـاپ ثىشفڊ ټ١ٽڃال سطٽٷ

ـ سطٽٷ فؼ ضدٽڇب ـا ثبال ثفؼڄ ڂ ثڅ ضدٻ ڀڇبڌڋ ثؽچڍٻ ، وذه ٻ ٻ څ ثڍٽب continuous. ټب ټدجڃـڌٻ اثشؽا ڀؽاـڀؽ

ڂ ث١ؽ ٻ ٻ قټبپ ـا ڃسبچشف ځڍٻ ڂ ضدٻ ـا ثبال ثجفڌٻ ڂ ثڅ خبڌڋ ثفوبڀڍٻ څ ثشڃاڀڍٻ ثفاضشڋ ثفوبڀڍٻ څ ټڋ غڃاچڍٻ

ثؽچڍٻ. bolus feedingثڅ ثڍٽبـ

Complications

• Tube displacement

• Tube occlusionMechanical

• Diarrhea

• Distention

• Nausea/ vomiting

• Residual

GI

• Fluid imbalance

• Electrolyte abnormalities

• HyperglycemiaMetabolic

:انتزال تغذیه عوارض

ثفاڊ ثڍٽبـ بـٴؿاشڅ ټڋ ڃؼ ثؽالڌٷ ټػشٹ٩ڋ ټٽٱٿ اوز غبـج څ NGډ ثڍٽبـ خبثدب ڃؼ . : ٸڃٸعوارض مکبنیکبل

ڃؼ ڂ ثبال ثڍبڌؽ. ثڅ چٽڍٿ غبف چف زځؽ ڂ٬ز ڌٱجبـ ثب ٬فاـ ؼاؼپ اوششڃوٱڃح ـڂڊ ټ١ؽڈ ثڍٽبـ، ثڅ ؼاغٷ ټ١ؽڄ چڃا

سكـڌ٫ ټڋ ځڍٻ سب ټٽئٿ ڃڌٻ ٸڃٸڅ ؼـ خبڊ غڃؼ اوز.

ـا ٠ڃ فؼ . NGاٴف ثىشڅ ڃؼ ثبڌؽ ڃؼ. ٴڍف ټڋ ځؽ ڌب ثىشڅ ټڋ NG tubeاوز . occlusionټٱٷ ث١ؽڊ

وڋ وڋ آة ڍف ثڃڌڍٻ . اٴف ڌٯ 50زٵڃڀڅ ټڋ سڃاپ دڍٵڍفڊ فؼ؟ ٬جٷ ڂ ث١ؽ اق چف ثبـ ٴبڂال فؼپ ثبڌؽ ٸڃٸڅ ـا ثب

ټف٦ ـ٬ڍ٫ فؼڄ ث١ؽ ٴبڂال ځڍٻ . ټبؼڈ ؼاـڂڌڋ ثڅ ثڍٽبـ ټڋ ؼچڍٻ څ ڂڌىٱڃقڌشډ ثبالڌڋ ؼاـؼ ټڋ سڃاڀڍٻ آڀفا ٬جٷ اق

اڌدبؼ ټڋ ځؽ ڂ firmingـڌػشڅ ټڋ ڃؼ ڌٯ ٨NG tubeفټڃالوڍڃڀڋ څ ؼاـاڊ ڂڌىٱڃقڌشډ ثبالڌڋ اوز ڂ٬شڋ ؼاغٷ

بټال ثڅ ؼڂـ ٸڃٸڅ ټڋ زىجؽ ڂ ثب٠ث ټڋ ڃؼ اڌٿ ٸڃٸڅ ـ٨شڅ ـ٨شڅ سځٳ سف ؽڄ ڂ چف ثبـ څ ٤ؿا ټڋ ؼچڍٻ ، دفڂسئڍٿ چب

ڂ ثب٠ث اڀىؽاؼ ټڋ ڃؼ. ـا ثڅ غڃؼ زىجبڀؽڄ

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عوارض گوارشی :

اوڇبٶ اوز. ثب ٴبڂال، ثؽٸڍٷ اڌځٱڅ ثڍٽبـ سطٽٷ ٴڃاـي ټځبوجڋ ڀؽاشڅ ڂ ڂ ٨فټڃٶ ـا ثب ڌٯ بڌ١شفڌٿ ٠بـڅ

ڃؼ ڂ ؼـ ڀشڍدڅ ثب٠ث ڊ ثبال ثڅ ڂڊ ؼاؼڌٻ، اوٽڃالـڌشڅ ثبال ثب٠ث خؿة آة قڌبؼ ؼـ ؼوشٵبڄ ٴڃاـڋ ټڋ اوٽڃالـڌشڅ

٨فاڂـؼڄ ثؽچڍٻ ڌ١ځڋ ڀ٧ half strengthؽ څ ٨فاڂـؼڄ ـا ثفاڊ خٹڃٴڍفڊ اق اوڇبٶ ٬جال ٴ٩شڅ ټڋڃؼ، اوڇبٶ ټڋ

ټڍكاپ آٸڃؼٴڋ ٴبڂال ـا ځؽ ڂ آة ثبؽ ڂ ڀ٧ ټػٹڃ ټڃـؼ ڀف، اڌٿ ـڂي ثؽٸڍٷ اڌځٱڅ ـڌىٯ اشجبچبر ـا قڌبؼ ټڋ

ځڍٻ. ثىشڅ ثڅ فاڌ ٠ز چبڊ دبڌڍٿ اوش٩بؼڄ ټڋوفاوڇبٶ اق ڃؼ. ثفاڊ خٹڃٴڍفڊ اق ؼڌٵف اوش٩بؼڄ ڀٽڋ ځؽ قڌبؼ ټڋ

ثڍٽبـڊ ١٨بٸڍز دفڌىشبٸشڍىٻ ـڂؼڄ اي چځڃق غڃة ڀڍىز ڌب ڀٽڋ سڃاڀؽ ټڍكاپ ټځبوجڋ اق ٨فاڂـؼڄ ثڍٽبـ اٴف ضؽن ثكڀڍٻ

وب٠ز ث١ؽ اٴف سطٽٷ 2ځڍٻ. وڋ وڋ ؼـ وب٠ز فڂ ټڋ15اق وف٠ز چبڊ دبڌڍٿ فڂ ټڋ ځڍٻ. ټثال ـا سطٽٷ ڀٽبڌؽ

ـڂق ثڅ آپ اڀفلڊ څ ټڍػڃاچڍٻ 1-2سڃاڀڍٻ ؼـ ڋ ڂ ټڋؼچڍٻ ڂ ث١ؽ ثڅ سؽـڌح ا٨كاڌ ټڋ 50، 40غڃة ثڃؼ ثڍٽبـ

سڇڃ ڂ اوش٩فا٢ ڂ . ټشى ڃؼ ثڅ ؼالڌٷ ټػشٹ٧ سڃاڀؽ اوز. ٱٻ ثڍٽبـ ټڋ distentionثفوڍٻ. ٠بـڅ ؼڌٵف

residual .چٻ اق ؼڌٵف ٠ڃاـ ٴڃاـڋ ټڋ ثبؽ

Gastric residual Volume: ٽڋ ـا څ ؼاغٷ آوذڍفڄ ټڋ ځڍٻ ڌ١ځڋ ټڍكاپ ضد اثشؽا چف ثبـ څ ټب ټڍػڃاچڍٻ ٴبڂال ځڍٻ

ثبؽ څ ثىشٵڋ ثڅ دفڂسٱٷ ټڃـؼ اوش٩بؼڄ ټب ؼاـؼ، ٴبڂال ـا ضؽڊ اق ڌٯ ټڋ وځدڍٻ. اٴف ثبالسف ټ١ؽڄ ثب٬ڋ ټبڀؽڄ

3ؼچڍٻ. ټثال ټب چف ټڋ ـا ٴبڂال ټطٹڃٶ ثڃؼاٴف ٻ ؽڄ ٴڍفڌٻ ڂ ؼـ ثبـ ث١ؽڊ ٴبڂال اڀؽاقڄ ټڋځڍٻ ؼچڍٻ، جف ټڋ ڀٽڋ

ثڅ ٴبڂال ـا ټبڀؽڄ ثڃؼ CC250ثبالڊ ثب٬ڍٽبڀؽڄ ځڍٻ، اٴف ٬جال آوذڍفڄ ټڋ ځڍٻ فڂ ټڋـا وب٠ز ثفاڊ ثڍٽبـ ٴبڂال فؼپ

ر ؼوشٵبڄ سڃاڀڍٻ اڀدبٺ ؼچڍٻ اڌٿ اوز څ ؼاـڂڌڋ ټثٷ ټشڃٹڃدفاټڍؽ ثؽچڍٻ څ ضفب اڀؽاقڌٻ، بـ ؼڌٵفڊ څ ټڋ سبغڍف ټڋ

ـا قڌبؼسف فؼڄ ڂ ثب٠ث سػٹڍڅ ڃؼ.ٴڃاـي

:عوارض متببولیک

ټٱالر آة ڂ اٸٱشفڂٸڍز، ټبڀځؽ اڌځٱڅ ثڍٽبـڊ څ ٬جال ؼزبـ بچ اڀفلڊ ثڃؼڄ، س٥ؿڌڅ ټځبوت ڂ غڃثڋ ڀؽاشڅ، ضبال

ځؽ څ سفص ټڋؼچڍٻ ڂ٬شڋ اڌٿ اڀفلڊ ثبال ـا ؼاؼڌٻ ثؽپ اڀىڃٸڍٿ قڌبؼڊ ـا ڀبٴڇبپ ثڅ ڂڊ اڀفلڊ ثبالڌڋ ـا ټڋ

Hyperglycemia ؼاغٷ ڃؼ څ ثىڍبـڊ اق اٸٱشفڂٸڍشڇبڊ ټب اق غڃپ ثڅ ـا ثذڃبڀؽ، سفص قڌبؼ اڀىڃٸڍٿ ثب٠ث ټڋ

re feedingڅ ثڅ آپ ڃؼ ڀبٴڇبپ ؼزبـ چبڌذڃ بٸٽڋ ، چبڌذڃ ټځڍكټڋ ڂ چبڌذڃ ٹىٽڋ ټڍ ځځؽ ڂ ث١ؽ ثڍٽبـ shiftوٹڃٶ

syndrome ځڍٻ ڂ آة ڂ اٸٱشفڂٸڍز بپ ـا ثب ؽر ثڍٽبـاڀڋ غڍٹڋ آـاٺ آـاٺ فڂ ټڋ زځڍٿ س٥ؿڌڅ ؼـ . ټب ٴڃڌځؽ

ځڍٻ سب اڌځٱڅ ؼزبـ زځڍٿ ټٱٹڋ ڀڃڌٻ. ځشفٶ ټڋ

ثڍشف سڃڍص ؼاؼڄ TPNاوز څ ؼـ ثطث hyperglycemiaځؽ ټٱٷ اڌدبؼ ټڋ feedingټٱٷ ؼڌٵفڊ څ

غڃاچؽؽ.

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Monitoring

Baseline

Serum glucose

Creatinine, BUN

Electrolytes

Serum glucose, Na, K, Cl, and bicarbonate should be determined daily until they are stable in hospitalized patients

Monitoring frequency is decreased to once or twice weekly when results are stable

Monitoring: دبـاټشف چب ـا ثڅ ڃـر ڌٯ وفڊ Base line فاسڍځڍٿ ڂ ، ٬ځؽ ټبڀځؽ ځڍٻ ٴڍفڊ ټڋ ثفاڊ ثڍٽبـ اڀؽاقڄ

BUN ٴٹڃك، وذه ځڍٻ. ځڍٻ ڂ ث١ؽ س٥ؿڌڅ ـا آ٤بق ټڋ ، اٴف ټٱٷ اٸٱشفڂٸڍشڋ ثبؽ چٽبپ اڂٶ االش ټڋچب ، اٸٱشفڂٸڍز

ڃؼ ڂ آپ فاڌ stableسب ڂ٬شڋ څ ثڍٽبـ ځڍٻزٯ ټڋ ، ٹف، ثڋ فثځبر ـا ثڃـر ـڂقاڀڅ وؽڌٻ، دشبوڍٻ

stressful ڂا١٬ب ثڍٽبـ اٴف زٯ ټڋ ځڍٻ. ڌٱجبـ ؼـ چ٩شڅ ڌب ؼڂثبـ ؼـ چ٩شڅ ث١ؽ . ڃؼاثشؽاڌڋ ـ٨stable ثبؽ ڂ ؼـ

سڃاپ اڀدبٺ ؼاؼ. ثبـ ؼـ وبٶ چٻ ټڋ 2سب 1ټځكٶ ثػڃاچؽ آڀفا اڀؽاقڄ ثٵڍفؼ ثڃـر

Monitoring

Ca, P, Mg are determined 2~3 times during the 1st week, then once weekly if the patient is stable

Nutrition monitoring: weekly albumin, pre-albumin, transferrin, nitrogen balance

Weight and fluid status: daily

GRV: q4~8h

ثبـ ؼـ اثشؽا اڀدبٺ ټڋ ؼچڍٻ ټثٷ 3سب 2ٽشف، ثدبڊ ـڂقاڀڅ چف چ٩شڅ frequencyڌٱىفڊ آقټبڌبر ؼڌٵف ـا ثب

ځڍٻ. ث١ؽ چ٩شٵڋ ڂ ث١ؽ ٨ڃاٷ ـا قڌبؼسف ټڋ ٹىڍٻ ، ٨ى٩بر ڂ ټځڍكڌٻ

زڍكچبڌڋ ـا اڀؽاقڄ ثٵڍفڌٻ:اڊ ټب ثبڌؽ زڅ ثفاڊ ٩بڌز س٥ؿڌڅ

ؼـ ڂقڀڋ څ ټب غڃاوشڍٻ چىز ڌب ڀڅ، اٱبٸڋ څ ڂخڃؼ ؼاـؼ اڌٿ اوز څ ؼـ ثڍٽبـ ثڍٽبـ ڌبآ ث٩ڇٽڍٻ ڂقپ ثڍٽبـ سب

ثىشفڊ ا٨كاڌ ڂ بچ ڂقپ ټڍشڃاڀؽ ثؽٸڍٷ ټٱالر آة ثبؽ، ټب ټڍكاپ قڌبؼڊ آة ثڅ ثڍٽبـ ؼاؼڌٻ، ثڍٽبـ ؼزبـ اؼٺ

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ڍٻ ٨بشڃـچبڌڋ ټبڀځؽ آٸجڃټڍٿ غڃپ، آئ ؽڄ ڂ ڂقڀ ثػبف آة اوز ڀڅ ثڅ غبف اڀفلڊ څ ؼـڌب٨ز فؼڄ، ثځبثفاڌٿ ټڋ

pre-alb ڌب ڀڍشفڂلپBalance ځڍٻ. ٨ف٬بپ اڌٿ اوز څ آٸجڃټڍٿ ـا ثفاڊ س٥ؿڌڅ ڃالڀڋ ـا ثفاڊ ثڍٽبـ ضىبة ټڋ

اڊ ڀؽاـؼ ، ڌٯ ټبڄ ث١ؽ قڂؼسف اق ټبچڋ ڌٱجبـ اٴف ثٵڍفڌٻ ٨بڌؽڄڂ اٴف ٴڍفڌٻ. زڃپ ڀڍٽڅ ٠ٽف ڃالڀڋ ؼاـؼ، ټڋاڀؽاقڄ ټؽر

آٸجڃټڍٿ چځڃق دبڌڍٿ ټبڀؽڄ اوز، ڌ١ځڋ س٥ؿڌڅ ټبپ غڃة ڀجڃؼڄ ڂ بٸفڊ ـا ا٨كاڌ ثڍځڍٻ ا اڀؽاقڄ ټڍٵڍفڌٻ ټڋآٸجڃټڍٿ ـ

اڌ ؼـ ثڍٽبـوشبپ ثىشفڊ اوز څ ټڍػڃاچڍٻ وفڌ١شف ڂ١ڍز س٥ؿڌڅ ICUټڍؽچڍٻ. اټب اٴف ثڍٽبـټبپ ؼـ ثػڋ ټثٷ

ـڂق ټڋ 3ـڂق# ثځبثفاڌٿ چف 2-1ڋ ڃسبڄ اوز $ڀڍٽڅ ٠ٽفي غڍٹ pre-albـا اڀؽاقڄ ټڍٵڍفڌٻ، Pre-alb ،غڃة ڃؼ

اڊ ـا ځشفٶ ځڍؽ. سڃاڀڍؽ ثب اڀؽاقڄ ٴڍفڊ آپ ڂ١ڍز س٥ؿڌڅ

وب٠ز ثىشڅ ثڅ 4 – 8چف څ آپ ـا څ ؼـ ټ١ؽڄ ټبڀؽڄ اوز ڌب چٽبپ ټڍكاپ ٤ؿاڌڋ GRVځڍٻ ټىئٹڅ ؼڌٵفڊ څ ځشفٶ ټڋ

ؽ ټٽٱٿ اوز ثڅ خبڌڋ ثفوڍٻ څ اال ؼڌٵفڊ stableثڍٽبـ، ځڍٻ ڂ ڂ٬شڋ څ ٴڍفڊ ټڋ فاڌ ثڍٽبـ ؼـ اثشؽا اڀؽاقڄ

ـا اڀؽاقڄ ٴف٨شڍٻ ثب وفڀٳ ٴبڂال ثڍفڂپ ڍؽڌٻ، ضشٽب آپ ټبڌ١ڋ څ ثڍفڂپ GRVالقٺ ڀجبؽ. ٨٭ ڌبؼټبپ ثبؽ ڂ٬شڋ

څ اٴف آڀفا دشبوڍٻ ڂ اٸٱشفڂٸڍز چب ؼاغٷ آپ ٬فاـ ؼاـؼ. ڋټڍكاڀ ڌؽ وف خبڊ غڃؼي ثبق ٴفؼؼ. قڌفا ڍؽڌٻ ضشٽب ثب

چبڌذڃبٸٽڋ ڃؼ. ثڍفڂپ ثفڌكڌٻ، ثڍٽبـ ټڍشڃاڀؽ ؼزبـ

٨فاڂـؼڄ چبڌڋ څ ؼـ ثبقاـ ڂخڃؼ ؼاـڀؽ زځؽ ڀڃ٠ځؽ:

اوز چٽبڀځؽ آثٽڍڃڄ چبڊ ټ١ٽڃٸڋ، ڌٯ ڀڋ چٻ ؼـ ځبـي ٬فاـ ؼاؼڄ ؽڄ. اڌٿ ـا ثڅ tetra packڅ ثڃـر ڀڃ اڂٶ

ـؼپ ـا ؼاـؼ اټب س٥ؿڌڅ اي ڀبب٨ڋ اوز اشڇب ڀؽاـؼ، ڀٽڍشڃاڀؽ ٤ؿا ثڍٽبـڊ ټڍؽچڍٻ څ چڃڍبـ اوز، غڃؼي سڃاڀبڌڋ غڃ

اوز څ اڌځڇب ـا ټڍشڃاڀڍٻ ثفاڊ ثڍٽبـ چڃڍبـ اوش٩بؼڄ Bag feeding, Bottle feedingـا غڃة ثدڃؼ. ؼڂ ڀڃ ث١ؽڊ

NGڅ اڊ ټثٷ څ چٽفاچ چىز ثڅ ٸڃٸ Administration setځڍٻ ڂ چٻ ثڃـر ٴبڂال، آڀفا آڂڌكاپ ټڋ ځڍٻ ڂ ثب

. ثڇشف اوز اق دٽخ چبڊ اڀ٩ڃقڌڃپ اوش٩بؼڄ ځڍٻ څ چف فز ڃؼ ڂٷ ڂ ثفاڊ ثڍٽبـ ٴبڂال ټڋ ostomyسڍڃح ڌب

س٥ؿڌڅ اڊ ثفاڊ غڃؼ ڀڃ غب غڃؼي ـا ؼاـؼ.

Preparations

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اڂـخڍځبٶ اوز څ fresubinڅ ؼـ ڃـ ڂخڃؼ ؼاـڀؽ ڂ ثڍشف ؼـ ؼوشفن چىشځؽ، اق ٨فاڂـؼڄ چب اڀڃا٠ڋ

1kcal/ml ټڍكاپ دفڂسئڍٿ ڂ اڀفلڊ ټڍؽچؽfresubin 3.8اڂـخڍځبٶgr 100ؼـ چفml .ده ثڅ اڌځٱڅ ڀڍبق ټڋ ثبؽ

ؼـ ځڍٻ. اڀفلڊ ڂ دفڂسئڍٿ ، ڌٱڋ اق ٨فاڂـؼڄ چب ـا اڀشػبة ټڋ ڂ ثف اوبن ڀڍبق ڂڊ ثڅ ڀٵبڄ ټڋ ځڍٻ ټشبثڃٸڍٱڋ ثڍٽبـ

ضدٻ چبڊ غڃثڋ ـا ټڍشڃاپ ثڅ آڀڇب ؼاؼ، اق چٽڍٿ ڂ اق ٸطب ټبڌ ؼزبـ ټٱٷ ڀڍىشڍٻثڍٽبـاڀڋ څ ٠بؼڊ چىشځؽ ڂ

fresubin اي ثبالوز، ڌب اڌځٱڅ ؼـ ضدٻ ټٱٷ ځڍٻ، اټب اٴف ثڍٽبـ ڀڍبق ټشبثڃٸڍٱڋ ڂ دفڂسئڍځڋ اڂـخڍځبٶ اوش٩بؼڄ ټڋ

ؽچڍٻ څ اڀفلڊ چىشڍٻ ضدٻ ٽشفڊ ث ټدجڃـ ڍٻ ثؽچڍٻؼاـڀؽ ټثال ثڍٽبـ ڀبـوبڌڋ ٹڍڅ ؼاـؼ ڂ چف ضدٻ آثڋ ـا ڀٽڍشڃاڀ

ؼاـؼ. دفڂسئڍٿ 7.5gr/100mlاڀفلڊ ڂ 1.5kcal/ml څټڍفڂڌٻ، fresubin HBثڅ وفا٢ ثڍشفڊ ؼاشڅ ثبؽ ده

denseبٸفڌٯ calshakeاوز، Calshakeټڃـؼ وڃټڋ څ ثفاڊ ثڍٽبـ غب اوش٩بؼڄ ټڍڃؼ،

اڀفلڊ ټڍؽچؽ. ؼـ چف وڋ وڋ 1.8kcalثب ڍفټػٹڃ ټڍڃؼ. څ سفڌٿ ٨فاڂـؼڄ اڌىز څ ټب ؼاـڌٻ. دڃؼـڊ اوز

ثځبثفاڌٿ اڀفلڊ ثبالڌڋ ؼاـؼ. ثفاڊ ثڍٽبـاڀڋ اوش٩بؼڄ ټڍڃؼ څ چڃڍبـ اوز، اټب ڂقڀ ثڃـ ؼائٻ ثؽٸڍٷ بٱىڋ ؼـ

اڀفلڊ ثفوبڀڍٻ، ده 600kcalټڍشڃاڀڍٻ اق ٨فاڂـؼڄ . ؼـ اڌٿ ٨فؼ ثب ڌٯ ٸڍڃاپبپ#$ټثٷ ثڍٽبـ ؼزبـ وفضبٶ بچ اوز

ـا ؼـ ـڂق اوش٩بؼڄ ځؽ اڀفلڊ اي خجفاڊ ټڍڃؼ اټب اٱبٸڋ څ ٨فاڂـؼڄ ٠ؽؼ اق اڌٿ 2ڌب 1غڍٹڋ غڃة اوز ڌ١ځڋ اٴف

ڂ آپ ، ٻق اڌٿ ٨فاڂـؼڄ اوش٩بؼڄ ځڍا ٻؼاـؼ ٽڋ دفسئڍٿ آپ اوز.ثځبثفاڌٿ اٴف ثڍٽبـ سطز اوشفن ثبالڌڋ اوز ڀٽڋ سڃاڀڍ

ثڍشف ؼـ ثبقاـ ټڃخڃؼ ټؽٶ 2چٻ څ ensureثفاڊ ىبڀڋ ټڍٵؿاـڌٻ څ ټڍػڃاچڍٻ ثؽٸڍٹڋ ڂقپ ثٵڍفڀؽ. ٨فاڂـؼچبڊ ـا

1kcalوبؼڄڀڃ چىشځؽ، HPاڂـخڍځبٶ ڂ fresubinؼ٬ڍ٭ب ټثٷ plusوبؼڄ ڂ ensure .اوز ڍبةڀڍىز ڂ غڍٹڋ چٻ ٽ

.ؼاـؼ دفڂسئڍٿ ٴفٺ 6.25اڀفلڊ ڂ plus ،1.5kcalڀڃ ڍٿ ڂٴفٺ دفڂسئ4اڀفلڊ ڂ

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س٥ؿڌڅ ڂـڌؽڊ

ټؽـن:ؼشف ضڍبسبچڋ

Total Parenteral

Nutrition (TPN)Alireza Hayatshahi, PharmDBoard Certified Pharmacotherapy Specialist

Pharmaceutical Care Department, Shariati Hospital

Candidates for receiving TPN

• GI obstruction

• Surgery, Trauma

• Chemotherapy, Radiation therapy

• GI cancers

• Inflammatory bowel disease

• Oral and enteral feeding intolerance

• Any surgery or procedure requiring patient to be NPO

• Involuntary weight loss, or loss of appetite

ىبڀڋ بڀؽڌؽ ؼـڌب٨ز س٥ؿڌڅ ڂـڌؽڊ چىشځؽ څ ثڅ چف ؼٸڍٹڋ اق ـڂؼڄ ڂ ټ١ؽڄ ڀشڃاڀځؽ اوش٩بؼڄ ځځؽ، ڀشڃاڀځؽ ثػڃـڀؽ،

obstruction .ؼاشڅ ثبځؽ ڂ ټب ټدجڃـڌٻ څ ثڅ آڀڇب اق فڌ٫ ڂـڌؽ س٥ؿڌڅ ـا ثفوبڀڍٻ

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Intestinal inflammation

ثشڃاڀؽ ٤ؿا ـا ثجٹ١ؽ خؿث ټػشٷ اوز ڌ١ځڋ ټب ڀٽڋ ٨فؼ اوز. ٠ٽال ضشڋ اٴف inflammationاق خٽٹڅ اڌٿ فاڌ

ځؽ، ده ؼـ ثڍٽبـڌڇبڌڋ څ ضبٸز اڌدبؼثڍشفڊ irritationٽٱٿ اوز ؼاڀڍٻ، خؿة ز٭ؽـ اڀدبٺ ټڍڃؼ، ٤ؿا غڃؼ ټ

Inflammatory ؼـ فاڌ ڂ ؼاـڀؽexacerbation .ټڍشڃاڀځؽ خؿة ـا ټػشٷ ځځؽ

Pros & cons

• Advantages

▫ Faster serum electrolyte and macronutrient correction

▫ Useful when GI is not functional

• Disadvantages

▫ Catheter related and soft tissue infections

▫ Thrombophelebites

▫ Damage to GI mucosal integrity

▫ Cost and complicated procedure

TPN ٿ ـڂي اٸٱشفڂٸڍشڇبڊ غڃپ اوز. ٽب ؼـ اڌ وفڌاالش غڍٹڋ اڌٿ ـڂيزڅ ټكاڌبڌڋ ؼاـؼ؟ اق خٽٹڅ ټطىځبر

ڌٯ االش وفڌ ڂ ؼڌٵف ؼ٤ؽ٤ډ خؿة ـا ڀؽاـڌٻ ڂځڍؽ، ټىش٭ڍٽب اٸٱشفڂٸڍشڇب، دفڂسئڍٿ، زفثڋ ـا ڂاـؼ غڃپ ثڍٽبـ ټڋ

ڂ ڌب ثڍٽبـاڀڋ څ وفبڀڋ چىشځؽ ڂ ڌب ثڍٽبـاڀڋ څ ثػبف ڀجبؽ functionalاٴف ؼوشٵبڄ ٴڃاـي .ټ٩ڍؽ اوز څ ؼاـڌٻ

ټب ؼـ ؼـؽ خؿة اٽڍځبپ ڀؽاـڌٻ. ؼـ ڌب اٸشڇبة ـڂؼڄ ؼاـڀؽ،چىشځؽ Mucositisؼزبـ Radiationڍٽڋ ؼـټبڀڋ ڌب

ـا ؼـڌب٨ز فؼڄ اڀفلڊ ڂ اٸٱشفڂٸڍز Basal وص ڌٯ ڂ اڌځڇب چٻ س٥ؿڌڅ ڂـڌؽڊ سب ضؽڂؼ قڌبؼڊ غڍبٶ ټب ـا ـاضز ټڍٱځؽ،

اڀؽ.

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ڋ ځڍٻ ، ټڃاؼ ٤ؿاڌڋ ثفاڊ اڌځٱڅ ثبال ټڋ ـڂؼ ، ټب ثڅ چف ضبٶ اق ـاڄ ڂـڌؽ ټڃاؼ ٤ؿاڌڋ ـا ڂاـؼ ټ infection ټڍكاپټ١بڌت:

ثڅ چف ضبٶ ټٽٱٿ اوز آٸڃؼٴڋ ڂاـؼ ڂـڌؽ ڂوب٠شڅ# 24ؽ $ځثبؼاشڅ ڃالڀڋ infusion timeټٱٷ اڌدبؼ ڀٱځځؽ ثبڌؽ

ؼ٬ڍ٫ ڀجبؽ ، ثف ضىت اڌځٱڅ TPNاوٽڃالـڌشڋ ټڋ ثبؽ. ڌ١ځڋ اٴف TPNاق ؼڌٵف ٠ڃاـ سفڂټجڃ٨ٹجڍز.ؼڃټفڌ

س٥ؿڌڅ ـا ؼـڌب٨ز ټڋ ځؽ ، ټٽٱٿ اوز ـٲ ټفڌ غفاة ڃؼ . ټىئٹډ ث١ؽڊ peripheral lineب ڌ centralثڍٽبـ اق ـاڄ

damage ڂ٬شڋ ، ثڅ چف ضبٶ ؼوشٵبڄ ٴڃاـي ټڋ ثبؽثڅ ؼوشٵبڄ ٴڃاـي Functional ، ڀجبؽ ؼزبـ ټٱٷ ټڋ ڃؼ

ڂخڃؼ ؼاـؼ زڃپ Costىئٹډ ټ ؼـ ڀڇبڌز ڂ .ثب٨ز دڃڋ ـڂؼڄ ثڅ چٻ ټڋ ـڌكؼ ٠integrityڃ ټڋ ڃؼ ، آپ ٨ٹڃـ

ثڅ چف ضبٶ س٥ؿڌډ ڂـڌؽڊ چكڌځډ ثبالسفڊ ؼاـؼ

Types of TPN

• Central PN

▫ Must have central line (through SCV to SVC)

▫ Or having PICC (Peripherally Inserted Central Catheterization) line

▫ High osmolarity is ok, high blood flow

▫ Concentrated solution is ok, good for limited fluid status

▫ Good for TPNs longer than 7 days

▫ 5%-10% AA, 20%-35% Dext

Types of TPN

• Peripheral parenteral nutrition

▫ Osmolarity limitations (< 900 mOsmol/lit)

▫ Risk of phelebites due to lower blood flow rate

▫ Must change the location every 2-3 days

▫ Ok for TPNs up to 7-14 days

▫ Large volume needed to dilute the ingredients

▫ 3%-5% AA and 5%-10% dext

central parenteral nutritionڂ Peripheral parenteral nutritionاڀڃا س٥ؿڌډ ڂـڌؽڊ :

peripheralټڋ سڃاپ اق ـاڄ ثٹٱڅ ڀڍىز vein subclavianڃـ اق ـاڄضشٽب ټځ central lineڂ٬شڋ ٴ٩شڅ ټڋ ڃؼ ڀٱشڅ:

PICC line(peripherally insertثفوبڀڍٻ څ ثڅ آپ االضب superior vena cavaڂاـؼ فؼڄ ڂ ثڅ ـا بسشف

central catheter).ٴ٩شڅ ټڋ ڃؼ

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PICC line

Routes of parenteral nutrition

Routes of nutrition

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ثفاڊ ټب ؼاـؼ اڌٿ اوز څ اوٽڃالـڌشڋ ثبال ـا ټڋ سڃاڀڍٻ ثڅ ثڍٽبـ ثؽچڍٻ ، ڌ١ځڋ ثػبف central lineټكڌز ټڇٽڋ څ

ټڍٹڋ 2000-1000خفڌبپ ثىڍبـ قڌبؼڊ څ ـٲ چبڊ ټفكڊ ؼاـڀؽ ، ټٱٹڋ ثفاڊ ـٲ دڍ ڀٽڋ آڌؽ ٽب اوٽڃالـڌشڋ

ؼـ اڌٿ ڂـڌؽ چب خفڌبپ غڃپ ڃؼ زڃپ ڍؽ ـٲ ؼزبـ ټٱٷ ڀٽڋ ڃؼ ، اٸشڇبة اڌدبؼ ڀٽڋ چٻ ثؽچ اوٽڃٶ ؼـ ٸڍشف

ڌٯ اقثبؽ TPNچ٩شڅ ثبڌؽ ـڂڊ 3ڂ ڀؽاـؼ GI Functional . ټفڌڋ ـا ٨ف ځڍؽ څ ثڅ چف ؼٸڍٹڋ ثىڍبـ ثبال اوز

central line ثؽڂپ اڌځٱڅ ټٱٹڋ ثفاڊ بؼڄ فؼس٥ؿڌڅ اوش٩چ٩شڅ ثفاڊ 3-2 ثٽؽر څ ؼـوز س١جڍڅ ؽڄ ثبؽ ټڋ سڃاپ

ثىڍبـ ثبالسف اوز، آټڍځڃ اوش٩بؼڄ ځڍٻ ٤central lineٹز آټڍځڃاوڍؽ ڂ ؼىشفڂق څ ټڋ سڃاڀڍٻ ؼـ ڂڂـڌؽ دڍ آڌؽ

ڂاـؼ ځڍؽ. central lineټڋ سڃاڀڍؽ اق TPN" ؼـ ٷ ڂاضؽ 35" ڂ ؼىشفڂق ـا سب 10اوڍؽ سب

ح سفخڍص ؼاـؼ ڌب ثڅ چف ؼٸڍٹڋ دكٯ ټ١بٸ bleedingټفڌ ـڌىٯ ٨بشڃـ اٴف اوز ، peripheral lineـاڄ ث١ؽڊ

ټٱٷ ؼـ اڌٿ ـاڄ ثڍٽبـ س٥ؿڌڅ ڃؼ . اڂٸڍٿ ټٱٷ ټب peripheralاوش٩بؼڄ ځؽ ڂ ټڋ غڃاچؽ اق ـاڄ CVlineؽچؽ اق ڀٽڍ

ڃب االپ ؼـ ؼڌؽڄ ؽڄ ټىئٹډ اوٽڃالـڌشڋ اوز ، غ practiceاوٽڃالـڌشڋ اوز. ټڇٽشفڌٿ ڀٱشڅ ثف اوبن آڀسڅ ؼـ

وبغشڅ ټڋ ڃؼ ڂ nursing stationؼـ TPNغڍٹڋ اڂ٬بر ، ، TPNڀجڃؼپ وبغز computerizeڃـ ټب ثب سڃخڅ ثڅ

Compound اوٽڃالـڌشڋ ثىف٠ز اق ڃؼؼىشفڂق ثڍ اق ضؽ اوش٩بؼڄ ثٵڍفؼ ڂ اٴف اشجبڄ ڃـر ڂټڋ ڃؼ

900mosmol ثبڌؽ ڂ بال ټڋ ـڂؼټڋ ٴؿـؼ ڂ ـٲ ؼزبـ ټٱٷ ټڋ ڃؼ ـڌىٯ ٨ٹجڍز ثline فؼـا ٠ڃ .

ټڋ ټڍٹڋ اوٽڃٶ ؼـ ٸڍشف 900اوٽڃالـڌشڋ ټطٹڃٶ اق فڌ٫ ـٲ دفڌ٩فاٶ ـڂق ثبڌؽ ٠ڃ ڃؼ . ټفق 3سب 2چف lineاڌٿ

lineځؽ، ثځبثفاڌٿ چٻ ثبؽ ـٲ ـا ؼزبـ ټٱٷ ټڋ 650-600غڃة اوز ، اٴف 850ثڅ اڌٿ ټ١ځڋ اڌٿ ڀڍىز څ ثبؽ.

" ڂ 5چ٩شڅ# غڃة اوز. آټڍځڃ اوڍؽ ضؽاثف 1-2چبڊ ڃسبڄ ټؽر $ TPNثفاڊ ـڂي ڃؼ. اڌٿثبڌؽ ټفسجب ٠ڃ

ثب اڌٿ ـڂي سدڃڌك ټڋ ڃڀؽ." 10 ضؽاثف ؼىشفڂق

Types of TPN

• 3 in 1 (TNA)

▫ Visualization

▫ Filter 1.2 micron

▫ Fungal infections

ـا ثڅ ڀڃ ؼڌٵف س٭ىڍٻ ځڍٻ: TPNاٴف

3in1 TPN: ؼـ اخكاڊ اٹڋ، ضدٻ چبڊ ثكـٴڋ څ ټبTPN ڌٻ؛ دفڂسئڍٿ، ؼىشفڂق ڂ ٸڍذڍؽ اوز. اڌځڇب ثف بـ ټڋ ثڅ

ضدٻ چبڊ ثكـٲ ټب چىشځؽ ڂ ضدٻ چبڊ ڃزٯ چٻ څ اٸٱشفڂٸڍشڇب، ڂڌشبټڍٿ ڂ اټالش ٽڍبة ڂ ٴبچڋ اڀىڃٸڍٿ. ضدٻ چبڊ

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ؼاشڅ ثبڍٻ، ڌ١ځڋ دفڂسئڍٿ ڂ ؼىشفڂق څ ټ١ٽڃال ثب چٻ اڀؽ، ٸڍذڍؽ 3in1 Bagثفڌكڌٻ ڂ Bagثكـٲ ـا ټڍشڃاڀڍٻ ؼـ ڌٯ

ـا TPNٻ ثڅ آڀڇب اب٨څ ځڍٻ. ضىٿ اڌځٱبـ اڌٿ اوز څ چٽڅ زڍك ؼـ ڌٯ ڂاضؽ اوز ڂ ٽب ڂ٬شڋ څ ؼـ ؼاـڂغبڀڅ ـا چ

ټٱٷ visualizationاق ٸطب اټبځؽ. وبقڌؽ ڌٯ ڂاضؽ ـا ثڅ دفوشبـ ټڍؽچڍؽ ڂ چٽبپ ـا ثفاڊ ټفڌ اڀ٩ڃقڌڃپ ټڋ ټڋ

ڃؼ ڌب Bagټػٹڃ ټڍڃؼ ڂ ؾـاسڋ څ ټٽٱٿ اوز ڂاـؼ اڌدبؼ ټڍٱځؽ ثڅ اڌٿ سفسڍت څ ٸڍذڍؽ ټڃخت ڍفڊ ـڀٳ ؽپ

ـا ؼـ چف ضبٶ TPNؼـ آپ اڌدبؼ ڃؼ ـا ڀٽڍشڃاپ ؼڌؽ. ثفاڊ خٹڃٴڍفڊ زڅ ټڍشڃاپ فؼ. ټڍشڃاپ ٨ڍٹشف فؼ، ټطٹڃٸڇبڊ

ڃ ټ١ٽڃٸڋ څ ثفاڊ آټڍځ TPNچبڊ ڀٽبئڍٻ، اٱبٸڋ څ اڌځدب ؼاـؼ ؾـار اټڃٸىڍڃپ زفثڋ اق ض٩فار ڃزٯ ٨ڍٹشف ٨ڍٹشف ټڋ

اوز ٠جڃـ ڀٽڋ ځؽ. ٨ڍٹشفڊ څ ثفاڊ زفثڋ اوش٩بؼڄ ټڋ ځڍٻ سب 2/0اوڍؽ ڂ ؼىشفڂق ڂ اٸٱشفڂٸڍشڇب ثٱبـ ټڍفڂؼ ڂ ٨ڍٹشف

اوز ڂ اڌٿ ٨ڍٹشف ؼـز سف اوز څ ثب اڌٿ ٨ڍٹشف ؼـز سف ؾـار فڌىشبٶ ټٽٱٿ اوز ٠جڃـ ځځؽ. 1.2ٸڍذڍؽ ٠جڃـ ځؽ

Types of TPN

• 2 in 1

• Filter 0.22 micron

• Infusion rates for lipid and AA/Dext

2in1TPN: وبؼڄ سف اوز، دفڂسئڍٿ ڂ ؼىشفڂق ـا ثب چٻ سفڍت ټڋ ځڍٻ، اٸٱشفڂٸڍشڇب ـا ثڅ آپ اب٨څ ټڋ ځڍٻ ڂٸڋ

24ثب اٸٱشفڂٸڍز ـا 2in1زفثڋ ـا خؽا ټڋ ؼچڍٻ، ضىٿ ثكـٴڋ څ اڌٿ ـڂي ؼاـؼ اڌٿ اوز څ ټڋ سڃاڀڍٻ ټطٹڃٶ

ا ټڍشڃاڀڍٻ ؼـ ټؽر قټبپ ڃسبڄ سفڊ ثؽچڍٻ وب٠ز ثؽچڍٻ ڂ زفثڋ ـا څ ـڌىٯ ٩٠ڃڀز چبڊ ٬بـزڋ ؼـ آپ ثڍشف اوز ـ

ځڍٻ زڃپ ټڍػڃاچڍٻ اڌٿ ؾـار ـا اوش٩بؼڄ ټڋ 0.2خؽا ڂاـؼ ټڋ ڃؼ. ؼـ ټڃـؼ اڌٿ ټطٹڃٸڇب ټب ٨ڍٹشف 1ineزڃپ اق ڌٯ

سب ضؽ اټٱبپ ٠جڃـ ڀٱځځؽ.

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Types of TPN

• Pre-made (manufactured)

▫ Less manipulation

▫ Fewer complicated processes

▫ Less time consuming

▫ Less expensive

• Customized

▫ More appropriate for complicated cases

س٭ىڍٻ ثځؽڊ ؼڌٵف:

TPNقڊ چبڊ آټبؼڄ، ڌٯ وفڊ اق فشڇبڊ ؼاـڂوبTPNوبقڀؽ. ڌ١ځڋ ټطٹڃٶ آټبؼڄ اڊ ڌ١ځڋ دفڂسئڍٿ ڂ چبڊ آټبؼڄ ټڋ

چبڊ ثكـٲ ـا ثب ڌٯ ضفز زفغڋ ٱىشڅ ڂ اڌٿ ټطٹڃٶ چب ثب چٻ Bagچبڊ خؽاٴبڀڅ، chamberؼىشفڂق ؼـ

ف چٻ ؼاـڀؽ، ڂٸڋ اٱبٶ اڌٿ اوز څ اٴوؽڌٻ ، دشبوڍٻ ڂ ٹىڍٻ ڀڍف basalټػٹڃ ټڍڃڀؽ، ڂ ڌٯ وفڊ اٸٱشفڂٸڍشڇبڊ

ثڍٽبـ ثڅ آپ سكـڌ٫ ځڍؽ، اٱبٶ اڌٿ اوز څ اٴف خؽاٴبڀڅ ثڍٽبـ اضشڍبج ثڍشفڊ ثڅ اٸٱشفڂٸڍز ؼاشڅ ثبؽ ٽب ثبڌؽ

ڃـڌٻ اق اڌٿ ټطٹڃٶ اوش٩بؼڄ ڀٱځڍٻ.، ټب ټدج ؼاـؼ ثبال وفټڋ ٹىڍٻٽب ثڅ چف ؼٸڍٷ دشبوڍٻ ڌب

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Process

• Comprehensive initial assessment

• Calculations and formulation

• Sterile admixture

• Administration

• Monitoring and adjustments

• TPN-drug interactions and compatibilities

Initial Assessment

• Lab checks

• Physical assessment

• Nutritional history

• Disease history

• Consideration of other diseases

▫ Renal

▫ Hepatic

▫ Respiratory

▫ Cardiac

Lab values

• Electrolytes

▫ Na, K, Cl, Acetate, Phos, Mg, Ca

• Renal function evaluation

▫ Cr, BUN, urine output

• Hepatic function

▫ ALT, AST, Alk Phos, Bili

• Protein status

▫ Albumin, tarnsfferin, prealbumin

• Lipid profile

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Calculations

• Caloric needs

▫ Protein

▫ Dextrose

▫ Lipid

• Protein

• Electrolytes, vitamins, trace elements, regular insulin

Calculations

• Protein

▫ Amino acid solution

▫ 10%, 5%

▫ With Electrolytes, w/o electrolytes

• Intralipids

▫ 10%, 20%

• Dextrose

▫ 50% solution

اڀدبٺ ټڍؽچڍٻ سب ڀڍبق اڀفلڊ ڂ دفڂسئڍٿ ثڍٽبـ ثؽوز آڌؽ. assessmentاڌٿ اوز څ ټب ڌٯ TPNدفڂوڅ بـ

$Calculation# ڂ formulation وذهټطٹڃٶ ـا فاضڋ ټڋ ځڍٻAdmixture ثىڍبـ ټڇٻ اوز ـا اڀدبٺ ټڋ ؼچڍٻ څ

Bagخكءـا ؼـ ڌٯ 40ڂاضؽ ثفوؽ ڌ١ځڋ ٽب 40ټطٹڃٶ ڀڍىز ضشڋ ټڋ سڃاڀؽ ثڅ 2ڌٯ ڌب TPNثبؽ. ثبڌؽ اوشفڌٷ ڂ

سڃاڀڍؽ ثفڌكڌؽ ثىشڅ ثڅ ڀڍبق ثڍٽبـ ټڋ

admixture اڀدبٺ ڃؼ. قڌف چڃؼ اوشفڌٷ ؼاـڂغبڀڅ ثبڌؽ Administration شبـڊ اوز ڂ ثىڍبـ ف٨ب بـ دفو

ؼـ ثىڍبـڊ اق ټڃاـؼ ؼڌؽڄ ؽڄ اوز څ دفوشبـ وب٠شڅ ثبؽ. 24ثىڍبـ ټڇٻ اوز ڂ ثبڌؽ infusion timeاچٽڍز ؼاـؼ

TPN وب٠شڅ 24اڊ ـا څ ٬فاـ اوزinfuse وب٠ز 4ڃؼ ؼـ ٠فinfuse فؼڄ اوز . ڂ ڌب آټڍځڃ اوڍؽ ـا خؽاٴبڀڅ

ثىڍبـ ټڇٻ اوز ، ټب اڌٿ ټطٹڃٶ ـا ڂاـؼ غڃپ monitoring. ؽڄ اوزسكـڌ٫ وب٠ز 2ڂٷ فؼڄ اڀؽ ڂ ؼـ ٠ف

monitorؼزبـ س٥ڍڍف ټڋ ڃؼ ڂ ټفڌ ثبڌؽ ـڂقاڀڅ ...ټفڌ ټڋ ځڍٻ ڌ١ځڋ اٸٱشفڂٸڍز ، دفڂسئڍٿ ، زفثڋ ، ٬ځؽ ڂ

فڊ څ ټڋ ؼاـڂچبڊ ؼڌٵ ثبڌؽ ټٽئٿ ثبڍٻ ؼاشڅ ثبڍٻ ، Compatibilityڃؼ ڂ ټڃـؼ ثىڍبـ ټڇٻ ؼڌٵف اڌٿ اوز څ

سؽاغٷ ڀؽاشڅ ثبځؽ. TPNغڃاچڍٻ ثڅ ټفڌ ثؽچڍٻ څ ثب

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ټىبئٹڋ څ ټب ثبڌؽ ثڅ آپ سڃخڅ ځڍٻ :

ټڇٻ اوز څ ټب ثؽاڌځٻ جؽ ثڍٽبـ ؼـ زڅ ضبٶ اوز ، اق ڀف ـڌڃڊ ثڍٽبـ ؼـزڅ ڂ١ڍشڋ اوز ، ز٭ؽـ ٸڍذڍؽ ڂ

چٽڍځڃـ ڂ١ڍز ٹڍڃڊ .ثڍشف سڃٸڍؽ ڀٱځڍٻ Co2 ڂثؽچڍٻ څ ؼزبـ اوشفن سځ٩ىڋ ثڍشف ڀڃؼ ثڅ ثڍٽبـ فثڃچڍؽـار

ز٭ؽـ ټبڌ١بر ـا ټڋ سڃاڀؽ سطٽٷ ځؽ. ثڍٽبـ زٵڃڀڅ اوز ڂ

ټبڀڍشڃـ ځڍٻ ، ڌٱىفڊ اق اٸٱشفڂٸڍز چب چىشځؽ څ ثڃـ TPNڅ ټب ثبڌؽ ٬جٷ اق فڂ دبـاټشف چبڊ آقټبڌٵبچڋ

ڂسئڍځڇبڊ وفٺ ثڍٽبـ ـا چٻ زٯ ټڋ ځڍٻ.ڂ ټڍكاپ دف Hepatic, Renal functionڂـڂقاڀڅ اڀؽاقڄ ٴڍفڊ ټڋ ځڍٻ

څ اٸٱشفڂٸڍز اڀؽ " اوز . ضشڋ دفڂسئڍٿ چبڌڋ ڂاـؼ ؽڄ10" ڂ 5چىشځؽ ټڃخڃؼ ټطڃالر دفڂسئڍځڋ څ االپ ؼـ ثبقاـ

ثڇشف اوز اق اڌٿ ڀڃ ثبال ؼاشڅ ثبؽ Na ڌب Mg.٠ٹش اڌٿ اوز څ اٴف ټفڌ ڂ ثبڌؽ ثڅ اڌٿ ڀٱشڅ سڃخڅ فؼ ؽڀچٻ ؼاـ

ڀڃؼ. اوش٩بؼڄ

Formulations

Calculations

• 1-calories

• 2-fluids

• 3-protein

• 4-calories from protein

• 5-calories from dextrose and lipid

• 6-electrolytes

• 7-vitamins and trace elements

• 8-add volumes

• 9-osmolarity calculation

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Calculations

• 1800 kcal/day• 88 g protein/day• 2500 ml fluid/day• 88 x 4= 352 kcal from AA• 880 ml AA• 1800-352=1448 kcal from lipid and dext• 1448 x 0.7= 1010 kcal from dext• 1010/3.4=298 g dext 50%=595 ml• 1448 x 0.3=434 kcal from intralipid 10%• 434/1.1=395 ml IL 10%• Qs to calculated volume with SW

Calculations

• Na▫ Phosphate▫ Acetate▫ Chloride▫ Bicarbonate is not compatible with TPN

• K▫ Phosphate▫ Acetate▫ Chloride

• Mg▫ Sulfate

• Ca▫ Gluconate

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Calculation:

ڂ١ڍز خڅ ثڅ فاڌ ثڍٽبـ ڂڅ ثڍٽبـ ڀڍبق ؼاـؼ ضىبة ټڋ ځڍٻ . ثب سڃ fluidټب بٸفڊ ـا ضىبة ټڋ ځڍٻ ، ټ٭ؽاـ

ٹڍڃڊ ټفڌ دفڂسئڍٿ ـا ضىبة ټڋ ځڍٻ ، ثال٨بٹڅ بٸفڊ دفڂسئڍٿ ـا ضىبة ټڋ ځڍٻ بٸفڊ ٷ ـا چٻ څ ؼاـڌٻ ،

بٸفڊ دفڂسئڍٿ ـا اق آپ ٻ ټڋ ځڍٻ ثب٬ڋ ټبڀؽڈ بٸفڊ ـا ثبڌؽ ثڍٿ زفثڋ ڂ ٬ځؽ دػ ځڍٻ. اڌٿ بـ ـا اڀدبٺ ټڋ ؼچڍٻ

500ccؼىشفڂق ثبڌؽ اوش٩بؼڄ ڃؼ ڌب 500ccدٽڋ ؼاـڀؽ ، ڌ١ځڋ ؼـ آغف ضىبة ټڋ ځڍٻ څ څ چف ؽاټبپ چٻ ض

ثبؽ ثبڌؽ آة اب٨څ ځڍٻ ڂ زفثڋ ، ټدٽڃ اڌځڇب ؼـ ثىڍبـڊ peripherallyآټڍځڃ اوڍؽ ڂ ضشڋ ثفاڊ ـ٬ڍ٫ فؼپ اٴف

Consult noteڌبپ ثبؽ ، ڌ١ځڋ ؼـ ٸڍشف ټڋ ـوؽ ، اڌٿ ثىڍبـ ټڇٻ اوز څ دكٯ ټ١بٸح ؼـ خف 2اق ثڍٽبـاپ ـاضز ثڅ

چب ثبڌؽ ٻ fluidٸڍشف اوز ، اٴف دكٯ القٺ اوز اق ضدٻ ٷ 2ټطبوجڅ ؽڄ TPNثبڌؽ ڀڃشڅ ڃؼ څ ټ٭ؽاـ ضدٻ

ځؽ.

ڌٱڋ اق ټىبئٹڋ څ ټب ؼـ اڌفاپ ؼاـڌٻ اڌٿ اوز څ ڀٽٯ چبڊ وؽڌٻ ڂ دشبوڍٻ ټب ؼـ اڌفاپ ټطؽڂؼ اوز . ټب ڀٽٯ چبڌڋ څ

سكـڌ٭ڋ ؼـ ؼوشفن ڀڍىز ، ثڅ ڃـر بر چٻ چٽڍڅ فاڌؽ ڂ ٨ى٩بر اوز . ڀٽٯ وؽڌٻ ٨ى٩ڌٻ وؽڌٻ ٹاق وؽڌٻ ؼاـ

ثكڂؼڊ ٬فاـ اوز ڂاـؼ ڃؼ ، اټب ڀؽاـڌٻ ، ڌ١ځڋ ؼـ ٨ڇفوز ؼاـڂڌڋ اڌفاپ چٻ ڀجڃؼڄ ، ڂ اوشبر چٻ دشبوڍٻ ٨ى٩بر

اوز. ٨ف ث٩فټبڌڍؽ ثڍٽبـڊ ټځڍكڌٻ ثڃـر ټځڍكڌٻ وڃٸ٩بر اوش٩بؼڄ ټڋ ڃؼ ڂ ٹىڍٻ چٻ څ ثڃـر ٴٹڃڃڀبر

اوز 19-25ڀفټبٶ څ rangeدبڌڍٿ غڃپ ڂ اوڍؽڂقڌه ؼاـؼ ڂ ثڍٱفثځبس چٻ اق PHؼاـڌؽ څ چبڌذف ڀبسفټڍب ؼاـؼ ،

ڀٽٯ اوشبر ڀؽاـڌٻ ، اوشبر ڀٽٱڋ اوز ټبغڃؼ ـا ٽڋ ٬ٹڍبڌڋ ځڍؽ ، TPN، ٽب ڀڍبق ؼاـڌؽ څ 15دبڌڍٿ سف اوز ټثال

ټڋ اق ڌٯ ـٲ ؼڌٵف # NaHco3$ثڍٱفثځبرؽ . االپ ټٽٱٿ اوز ټفش ڃؼ څ ثڅ ټفڌ وؽڌٻ ـا ٬ٹڍبڌڋ ټڋ ځ TPNڅ

ټب ثفاڊ اڌٿ ټفڌ ؼزبـ ټٱٷ چىشڍٻ. اڀشػبة ټځبوجڋ ڀڍىز ڂؼچڍٻ ، ڂٸڋ ټفڌ ؼزبـ چبڌذف ڀبسفټڋ اوز ده اڌٿ

ثڅ آقټبڌبر ؼڌٵف ، اٴف ـا ؼـ ؼوشفن ؼاشڅ ثبڍٻ سب ثب سڃخڅ وؽڌٻ ڂ دشبوڍٻ ده ثىڍبـ ټڇٻ اوز څ چف وڅ ڀٽٯ

٨ى٩بر ڌب ٹفاڌؽ ڌب اوشبر ؼزبـ س٥ڍڍف ؽڄ ، ثشڃاڀڍٻ اق اڌٿ ڀٽٯ چب اوش٩بؼڄ ځڍٻ . ٹىڍٻ ٴٹڃڃڀبر ثڃـر ټطٹڃٶ

اوز. ټڃخڃؼ " 20" ڂ 50" ڂ ټځڍكڌٻ وڃٸ٩بر ثڃـر ټطٹڃٶ 10

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Calculations

• B vitamins

• Vit C

• Vit A

• Vit E

• Vit K

• Vit D

Calculations

• Trace elements

▫ Copper

▫ Manganese

▫ Selenium

▫ Zinc

▫ chromium

چب ټڇٻ چىشځؽ ثػڃ Trace elementټڍٿ ، ڂڌشبټڍٿ چبڊ ټطٹڃٶ ؼـ زفثڋ ڂ آة ؼـ آڀڇب ڂخڃؼ ؼاـؼ . ټڃٸشڋ ڂڌشب

، chronicغڃاچڍٻ ، ڂٸڋ اٴف ثڍٽبـ ثػڃاچؽ ثڃـر ٽڋ ڀ trace elementؼـ ڃسبڄ ټؽر TPNؼـ ؼـاق ټؽر. ثفاڊ

TPN ؼـ ڂاځ چبڊ ضڍبسڋ ث١ځڃاپ ڃ٨بشڃـ ثٵڍفؼ ، ؼزبـ ٽجڃؼ اټالش ٽڍبة ټڋ ڃؼ ، څ س١ؽاؼ قڌبؼڊ اق آڀڇب

ڂ٠ؽڄ ؼـ 1اوش٩بؼڄ ټڋ ڃڀؽ . قڌځٯ ؼـ اٸشڍبٺ قغٻ ثىڍبـ ټڇٻ اوز . اٴف ټفڌ ثشڃاڀؽ قڌځٯ غڃـاڋ ثٵڍفؼ ضؽا٬ٷ

.#ټب اق ـاڄ ڂـڌؽڊ ١٨ال قڌځٯ ڀؽاـڌٻ$ٻ ڍسڃڍڅ ټڋ ځ enteralـڂق قڌځٯ ـا اق ـاڄ غڃـاڋ ڌب

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Calculations

• Regular insulin

اڀىڃٸڍٿ :

اب٨څ ځڍٻ TPNثڅ اڀىڃٸڍٿ ـا چٻ ، ټب ټڋ سڃاڀڍٻ ثفڂؼزڅ ثڍٽبـ ؼڌبثشڋ ثبؽ زڅ ڀجبؽ ټٽٱٿ اوز څ ٬ځؽ غڃڀ ثبال

څ ؼـ ـڂق اڀىڃٸڍٿ آپ ټڍكاپ 1/3سب ½ ث١ؽ اق ڌٯ سب ؼڂ ـڂقثؽچڍٻ ثڅ ټفڌ خؽاٴبڀڅ Sliding scaleڂ چٻ ثڃـر

ث١ؽ ټػ ڃؼ ڂ ٬ځؽ غڃپ ټفڌ trend سب جف ټڋ ځڍٻ ڌ١ځڋځڍٻ . اب٨څ ټڋ TPNثڅ ټفڌ ټڋ ؼاؼڌٻ ، ثڅ

اب٨څ ټڋ ځڍٻ. TPNآڀفا ثڅ

Osmolarity

• AA (g) per liter x 10 plus

• Dext (g) per liter x 5 plus

• (Mg, Ca, Na, K) x 2 plus

• App. 150 mOsm/lit from vitamins and trace elements

• (35x10)+(119x5)+(180x2)+150=1450 mOsm/lit

• Central Line Only

ٴفٺ چف اٴفـا وفڌ ثبال ټڋ ثفڀؽ ، TPNاوٽڃالـڌشڋ ثىڍبـ اچٽڍز ؼاـؼ . دفڂسئڍٿ ڂ ؼىشفڂق ثػڃ اوٽڃالـڌشڅ

آټڍځڃ اوڍؽ ؼـ 100grټثال اٴف $ ځڍٻ،اوٽڃالـڌشڅ آپ ثؽوز ټڋ آڌؽفة 10ؼـ ا ـ ٻآټڍځڃ اوڍؽڊ څ ؼـ ڌٯ ٸڍشف ؼاـڌ

ڂ فة ټڋ ڃؼ 5ؼـ ټڍكاپ ٴفٺ آپ ؼـ ٸڍشف ؼىشفڂق ؼـ ٸڍشف ټڋ ڃؼ#. ؼـ ټڃـؼ mosmol 1000، ٸڍشف ؼاـڌٻ 1

mosmol 150ؼٶ چٻ ټ٭ؽاـڊ ټ١ب trace elementفة ټڋ ڃؼ ، ټ٭ؽاـ ټڃٸشڋ ڂڌشبټڍٿ ڂ 2اٸٱشفڂٸڍز چب ؼـ

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٬بثٷ peripheral lineثبالسف ـ٨ز 900mosmol/lit اق چٽڅ ـا ثب چٻ خٽ ټڋ ځڍٻ ، اٴف اوٽڃالـڌشڅ اڌدبؼ ټڍٱځځؽ څ

اوش٩بؼڄ ڀڍىز .

Points to be considered

• Renal insufficiencies▫ Electrolytes ▫ Protein amounts▫ Trace elements▫ Fluid balance

• Hepatic insufficiencies▫ With encephalopathy▫ Amino acids formula▫ Acetate metabolism▫ Trace elements

Renal, hepatic function ، ټڇٻ اوز

Points to be considered

• Pulmonary

▫ Carbohydrates, IL, fluids

• Pancretitis

▫ IL

• Diabetes

▫ Carbohydrates, insulin

• Cardiac

▫ Sodium and fluid overload

ڋ څ ټڋ غڃاچڍٻ ثڅ ثڍٽبـ ثؽچڍٻ ثبڌؽ ضدٽچىشځؽ ده ټب ؼـ ټ٭ؽاـ fluid retentionب ؼزبـ ڌٱىفڊ اق ټفڌ چبڊ ټ

ثىڍبـ ؼ٬ڍ٫ ثبڍٻ .

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Admixture

Admixture

• From 10 to over 40 injectable items to be mixed in a bag

• Long infusion time

• Prevention of CV or peripheral line infection and bacteremia

• Compatibility considerations

• Consistency

• Under pharmacist direct supervision

Admixture

• Large volumes

▫ Lipid stability (3 in 1)

• Electrolytes

▫ Calcium-phosphate

• Multivitamins

• Trace elements

• insulin

Admixture .اوشفڌٷ قڌف چڃؼ سٽڍك ڂ اسب٪ سٽڍك ؼاـڂغبڀڅ

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ـا ټڋ ٴڍفؼ. TPNثب ٷ ټطٹڃٶ Incompatibilityڃؼ ، اڌٿ بـ خٹڃڊ ـڌىٯ infuseٸڍذڍؽ خؽاٴبڀڅ ثڇشف اوز

On the label

• Patient’s info

• Total volume of TPN

• The term “Central Line” or “Peripheral Line”

• Rate of infusion as ml/hr

• Amount and volume of each ingredient

• Osmolarity

• Date of admixture

• Initials or stamp of compounder pharmacist

ثبڌؽ اڌٿ ټڃاـؼ ؾف ڃؼ : Labelـڂڊ

ؾف ڃڀؽ. bag، اوٽڃالـڌشڋ ثبڌؽ ـڂڊ volume ،rateڀبٺ ټفڌ ،

اوز ڂٸڋ اٴف ثڍٽبـ ڀبـاضشڋ ٹڍڃڊ ڌب جؽڊ ؼاـؼ ، ڌٯ ټطؽڂؼڌز چبڌڋ ـا اٹڋ ټب س٥ؿڌڅ ثڍٽبـ goalؼـوز اوز څ

ؼـ ٨فټڃالوڍڃپ ټب اڌدبؼ ټڋ ځؽ.

ټڋ سڃاڀځؽ ٨ى٩ف ، دشبوڍٻ ڂ ټځڍكڌٻ ڌب ڌٯ وفڊ اق ٠ځبف ٽڍبة ټثٷ څ ڀبـوبڌڋ ٹڍڃڊ ؼاـڀؽ ، اڌځڇب ټثال ثڍٽبـاڀڋ

selenium ځڍٻ. دفڂسئڍٿ ثىڍبـ ټڇٻ اوز ټڃڀڍشڃـ ـاپ ثبڌؽ ټفا٬ت ثبڍٻ ڂ اڀجبشڅ ځځؽ ده ټب ؼـ اڌٿ ثڍٽبؼـ ثؽپ ـا

، ثڍٽبـاڀڋ څ ؼزبـ ڀبـوبڌڋ ٹڍڃڊ چىشځؽ بڌؽ ؼـ ؼ٨ دفڂسئڍٿ ؼزبـ ټٱٷ ڃڀؽ ، دفڂسئڍٿ قڌبؼ ڂ اخكاڊ دفڂسئڍځڋ

جبشڅ ڃؼ ؼـ غڃپ اڀ ؽچب ٠ف ؽ څ وٹځڍڃٺ ټڋ سڃاڀ trace elementقڌبؼ ٹڍڅ ـا ؼزبـ ټٱٷ ټڋ ځؽ . اق ڀف

uresis، ىڋ څ ڀبـاضشڋ ٹڍڃڊ ؼاـؼ ڀٽڋ سڃاڀؽ ټبڌ ؼ٨ ځؽ ڌ١ځڋ fluid balanceڅ اڌدبؼ اٱبٶ ټڋ ځؽ . اق ڀف

TPNثڍٽبـ ثڅ ضؽ ب٨ڋ ڀڍىز ڂ ثڍٽبـ ؼزبـ اڀجبشٵڋ ټبڌ١بر اوز . ؼـ اڌٿ ثڍٽبـاپ ثبڌؽ ثؽر ټفا٬ت ثبڍٻ . ؼـ

اڌځٱڅ ثػڃاچڍؽ دفڂسئڍٿ ثبالڌڋ ـا ثڅ ثڍٽبـ ثفوبڀڍؽ ثػڃ ثب ٤ٹز ثىف٠ز ضدٻ ثبال ټڋ ـڂؼ ڂ ٽب ثڅ ټط

وڋ وڋ ټڋ ـوؽ ، اٴف ثػڃاچڍٻ ٬ځؽ 1000-500چبڌڋ څ ټب االپ ؼـ ثبقاـ اڌفاپ ؼاـڌٻ ثفاضشڋ اڌٿ دفڂسئڍٿ ضدٽ ثڅ

ٻ څ چىز. ڌ١ځڋ ټب ثفوبڀڍٻ ثڅ اڀؽاقڄ اڊ څ بٸفڊ ـا سأټڍٿ ځؽ ، ضدٻ ثبال ټڋ ـڂؼ ڂ ثڅ ڌٯ ٸڍشف ټڋ ـوؽ ڂ ٸڍذڍؽ چ

ټڋ ؼچڍٻ. TPN ٸڍشف ؼـ ـڂق ؼاـڌٻ اق فڌ٫ 2ټشڃو

ڌ١ځڋ ټڍكاپ ڀڍشفڂلپ فوڍؽڄاڀى٩بٸڃدبسڋ ڀثڅ ټفضٹڅ اٴف جؽڊ اچٽڍز ؼاـؼ. ڀبـوبڌڋ ؽر ؼـ ڀبـوبڌڋ جؽڊ، اڂال

ڂٸڋ اٴف ټفڌ ټ٭ؽاـڊ دفڂسئڍٿ ثؽچڍٻټڋ سڃاڀڍٻ غڃپ ثڅ ضؽڊ ثبال ڀف٨شڅ څ ثڍٽبـ ؼزبـ ټٱالر ټ٥كڊ ڃؼ ټب

دفڂسئڍٿ ـا دبڌڍٿ سف ثٵڍفڌٻ سب آټڃڀڍبٮ ڂ ڀڍشفڂلپ ٽشفڊ ؼـ غڃپ سڃٸڍؽ ڃؼ ڂ rateؼزبـ اڀى٩بٸڃدبسڋ ؽڄ ثبڌؽ

دفڂسئڍٿ اوش٩بؼڄ ټڋ ځڍٻ ڌ١ځڋ ضؽا٬ٷ ټ٭ؽاـ 0.6gr/kgوص ڀڍشفڂلپ غڃپ ثڍ اق ضؽ ثبال ڀفڂؼ څ ؼـ آپ ڃـر

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ڌكؼ ، ثځبثفاڌٿ ثڍٽبـڊ څ ؼزبـ ڀبـوبڌڋ جؽڊ اوز چٽفاڄ ثب اڀى٩بٸڃدبسڋ ، ثڅ چٻ ڀف ڋدفڂسئڍځ balanceدفڂسئڍٿ ، سب

آټڍځڃ اوڍؽ چب ثبڌؽ ثدبڊ آټڍځڃ اوڍؽ چبڊ ؼـ ټڃـؼؼـ ټ٭ؽاـ دفڂسئڍٿ ڂ ڀڃ دفڂسئڍٿ ټڃـؼ اوش٩بؼڄ ثبڌؽ سڃخڅ ځڍٻ .

ٽبپ ثفاڊ جؽ ـاضز ثبؽ . اوش٩بؼڄ ځڍٻ سب ټشبثڃٸڍى branchآـڂټبسڍٯ څ ضبٸز ضٹ٭ڃڊ ؼاـڀؽ اق آټڍځڃ اوڍؽ چبڊ

اوشبر ڂ٬شڋ ڂاـؼ غڃپ ثبڌؽ ؼ٬ز ځڍٻ څ ټڋ غڃاچڍٻ اوشبر اوش٩بؼڄ ځڍٻ ڂ ثڍٽبـ ټب ؼزبـ ڀبـوبڌڋ جؽڊ اوز ، اٴف

. ده اڌٿ سجؽڌٷ ـظ ڀٽڋ ؼچؽ ڂ اوشبر سدٽ دڍؽا ټڋ ځؽڃؼ ثبڌؽ جؽ آڀفا ثڅ ثڋ فثځبر سجؽڌٷ ځؽ ،

ؽ ڀاٴف ڀبـوبڌڋ جؽڊ ڌب ٹڍڃڊ ؽڌؽ ؼاـ٠ث وٽڍز ټڋ ڃڀؽ. ؼـ غڍٹڋ اق ثڍٽبـاپ ؼـ ڀبـوبڌڋ جؽڊ ثب ټه ڂ ټځٵځك

trace element ـڂق ؼـ ټڍبپ سدڃڌك ټڋ ڃؼ. 1ثڃـر

ڀٽڋ ځؽ. ڌ١ځڋ ڌٯ ځشفااڀؽڌٱبوڍڃپ ڀڍىز . اڌدبؼ اٴف ثڍٽبـڊ دبڀٱفاسڍز ؼاشڅ ثبؽ اٸكاټب اوش٩بؼڄ اق ٸڍذڍؽ ټٱٷ

بقاپ ټب ؼزبـ وڃءس٩بچٻ ټڋ ڃڀؽ څ اٴف ثڍٽبـ دبڀٱفاسڍز ؼاـؼ ٸڍذڍؽ ڀؽچڍٻ ، اٴف څ ثىڍبـڊ اق دكٱبپ ڌب ؼاـڂو

فؼپ ، monitorؽ. ثفاڊ ځټفڌ ثشڃاڀؽ ٸڍذڍؽ ـا سطٽٷ ڀٽبڌؽ ڂ ؼزبـ چبڌذف سفڊ ٴٹڍىفڌؽټڋ ڀڃؼ اڌدبؼ اٱبٶ ڀٽڋ

ـا ټبڀڍشڃـ ټڋ ځڍٻ اٴف ٽشف اق وب٠شڅ څ ثڅ ثڍٽبـ ؼاؼڄ ؽڄ ، سفڌٵٹڍىفڌؽ ټفڌ intralipid 10وب٠ز ث١ؽ اق 4

ڂ ث١ؽ ځڍؽhold ـا ـڂڊ ثفاڊ زځؽ ـڂق Intra lipidثبؽ ټڋ سڃاپ اؼاټڅ ؼاؼ ڂٸڋ اٴف ثڍشف ثبؽ ټڋ سڃاڀڍؽ 350-400

ـڂق ؼـ ټڍبپ ثڅ ټفڌ ثؽچڍؽ ، ده اٸكاټب اٸشڇبة دبڀٱفان ځشفااڀؽڌٱبوڍڃپ ثفاڊ اوش٩بؼڄ اق ٸڍذڍؽ ڀڍىز . 1اق آپ

ثڍٽبـ وب٠ز ڌٱجبـ ٬ځؽ 6ڂ چف sliding scaleاڀىڃٸڍٿ ـا ضشٽب ثبڌؽ ثڅ ثڍٽبـ ټفست ثؽچڍٻ ثب سڃخڅ ثڅ ؼڌبثشڋ ـ ثڍٽبـاپؼ

. ڍٻاب٨څ ټڋ ځ TPNڀ٧ آپ ـا ثڅ ټڍكاپ اڀىڃٸڍٿ ټڃـؼ ڀڍبق ثڍٽبـ ټػ ؽڄ ڂـڂق 3-2. ث١ؽ اق ټڋ ڃؼزٯ

څ ثڍٽبـ ؼزبـ چبڌذڃٴالڌىٽڋ ڀڃؼ. ثبؽ TPNسفڌٿ ـڂي اب٨څ فؼپ اڀىڃٸڍٿ ثڅ safeاڌٿ بڌؽ

اوز ، چٻ ثبڌؽ ؼـ ټ٭ؽاـ وؽڌٻ ڂ چٻ ؼـ ټ٭ؽاـ CHFدڍ ټڋ آڌؽڂ ټفڌڋ څ ؼزبـ fluidچٻ ثطث وؽڌٻ ڂ ٬ٹجڋ اق ڀف

fluid ؼ٬ز ڃؼ. ثبڌؽ څ ثڅ ټفڌ ؼاؼڄ ټڋ ڃؼ

Admixture: اٴف څوب٠ش 24اڌځڇب ټطٹڃٶ چبڌڋ چىشځؽ څ$Cyclic TPN #ڀجبؽinfuse ڃٶ ټڋ ڃڀؽ ، ڌ١ځڋ ټطٹ

ٻ اوز ڂٸڋ bag. ؼـوز اوز څ اوٽڃالـڌشڋ ثبالوز ڂ بڀه ـؽ ټڍٱفڂثڋ ؼـ غڃؼ دفڂسئڍٿ ، ٬ځؽ ڂ اٸٱشفڂٸڍشڇب

LINE ټٽٱٿ اوز آٸڃؼڄ ڃؼ ثځبثفاڌٿ ثفاڊ اڌٿ څ ټب اڌځفا ثڅ ضؽا٬ٷ ثفوبڀڍٻ ثبڌؽadmixture اوشفڌٷ ثبؽ. ضؽا٬ٷ

قڌف چڃؼ اوشفڌٷ ؼـ ؼاـڂغبڀڅ ؼـوز فؼڄ اڌٻ.آپ ـا څ غڃؼټبپ ث١ځڃاپ ؼاـڂوبق ثؽاڀڍٻ

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Monitoring

• Daily labs

▫ Na, K, Cl, Acetate, Cr, BUN, FBS

• Twice weekly labs

▫ Mg, Phos, Ca, CBC

• Weekly Labs

▫ Alb, LFTs, TG, INR

• Glucose to be checked every 6 hours and be adjusted by SSI

اڀدبٺ ڃؼ: TPNآقټبڌبسڋ څ ـڂقاڀڅ ثبڌؽ اق قټبپ آ٤بق

ـا زٯ ټڋ FBSڂ BUNٴڍفڌٻ ، وفٺ فاسڋ ڀڍٿ ، دشبوڍٻ ، ٹف ڂ اوشبر ـا اڀؽاقڄ ټڋ ـڂقاڀڅ اٸٱشفڂٸڍز چبڊ وؽڌٻ ،

ځڍٻ.

٩٠ڃڀز ثفـوڋ ثػبف CBCاوز . CBCڅ ٽشف ڀڍبق ؼاـڌٻ ـڂقاڀڅ زٯ ڃڀؽ ټځڍكڌٻ ، ٨ى٩بر ، ٹىڍٻ ڂ ڋآقټبڌبس

څ آقټبڌبسڋ څ ڂاـؼ فؼڄ اڌٻ اڌدبؼ ٩٠ڃڀز ڀٱفؼڄ ثبؽ . lineثڍشف اڀدبٺ ټڋ ڃؼ ڂ ټڋ غڃاچڍٻ ثجڍځڍٻ څ

، سفڊ ٴٹڍىفڌؽ ڂ ... LFTڃڀؽ آٸجڃټڍٿ ، ټڋ ثڃـر چ٩شٵڋ زٯ

Monitoring

• Fluid In/Out

• Patient’s wt

• IV site inspection for possible infection

• Any drug added to the pharmacotherapy regimen to be checked for possible interaction and incompatibility with TPN formula

Monitoring:

خكء 40ټطٹڃٸڋ اوز څ ټڋ سڃاڀؽ بټٷ TPNؼاـڂ اوز . –ؼـ ـاثڅ ثب ټبڀڍشڃـڌځٳ ڌٯ ټىئٹډغڍٹڋ ټڇٻ سؽاغٷ ؼاـڂ

ؽ ، ڌٱڋ اق ثبځ TPN compatibleثځبثفاڌٿ سدڃڌك ؼاـڂچبڊ ؼڌٵف ثػڃ اق چٽبپ ـاڄ ، ثبڌؽ ثب ثبؽ. ټػشٹ٧

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آپ ؼـ وبٶ اوز څ آغفڌٿ ڂـلپ injectable drugsشبة TPNثب Compatibilityڊ زٯ فؼپ ثڇشفڌٿ ټفاخ ثفا

ـا سطز TPN ثب ثفاڊ سٽبٺ ؼاـڂچب ، ڀڅ ٨٭ وبقٴبـڊ ڂاـؼ ؽ ڂ ټب ټڋ سڃاڀڍٻ اق آپ اوش٩بؼڄ ځڍٻ . اڌٿ شبة 2009

دڃ ؼاـؼ .

Drug interactions

• Propofol

▫ Rate dependent

• Ceftriaxone

▫ Calcium precipitation

• Sodium bicarbonate

Incompatibility:

ؼاـڌٻ ڂ ټڃـؼڊ mechanical ventilationاوش٩بؼڄ ټڋ ڃؼ ، ثفاڊ ثڍٽبـاڀڋ څ ICUؼـ sedationٷ ثفاڊ دفڂدڃ٨

دفڂدڃ٨ٷ ټڋ سڃاڀؽ ـڂڊ اڌځٱڅ ټب ثػڃاچڍٻ ٸڍذڍؽ ثڅ ثڍٽبـ ثؽچڍٻ ڌب ڀؽچڍٻ اثف rateڅ ثفاڊ ټب ټڇٻ اوز اڌٿ اوز څ

ټڋ holdڀؽاـؼ ڂ ٸڍذڍؽ ـا ـڂڊ intralipidڍبج ثڅ ثبؽ ټفڌ اضش 50mg/kg/minدفڂدڃ٨ٷ ثڍ اق rateاٴف ؼاـؼ.

ٴؿاـڌٻ ، ټفڌ ؼاـؼ اق آپ ټ٭ؽاـ دفڂدڃ٨ٷ اڀفلڊ القټڋ ـا څ ٽب اق ٸڍذڍؽ ټڋ غڃاوشڍؽ ټڋ ٴڍفؼ.

ثػبف ڂخڃؼ lineاوز. ټبٸ١بر اغڍف ڀبپ ؼاؼڄ څ ثػڃ ؼـ سدڃڌك چٽكټبپ ڂ اق ڌٯ ceftriaxoneټڃـؼ ؼڌٵف

. ده ضؽا٬ٷ بـڊ څ ټڋ سڃاپ فؼ اڌٿ اڌدبؼ ڀٽبڌؽ ـوڃة ٹىڍٻڂ ز اڌدبؼ اٱبٶ ڀٽبڌؽ ټٽٱٿ او TPNٹىڍٻ ؼـ

ڀؽچڍٻ. lineاق ڌٯ ڂ و٩شفڊ اىڃپ ـا TPNاوز څ

ڀجبڌؽ سدڃڌك ڃڀؽ. Lineڀبوبقٴبـڊ ؼاـؼ ڂ اق ڌٯ TPNوؽڌٻ ثڍٱفثځبر چٻ ثب ټطٹڃٶ

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TPN therapy complications

• Re-feeding syndrome risk factors:▫ BMI less than 16 kg/m2▫ More than 15% unintentional weight loss within

last 3-6 months▫ little or no nutritional intake for more than 5 days

• Intracellular electrolyte shift• hypoMg, hypoK, hypoPhos• Hyperglycemia, hyper insulinemia• Prevention: start TPN with 50% of energy

requirements for the 1st two days

Re feeding syndrome:

اڀىڃٸڍٿ ثبال ټڋ ـڂؼ ، اڀىڃٸڍٿ ،ؽچڍٻث ټ٭ؽاـ قڌبؼڊ ٬ځؽ ، دفڂسئڍٿ ڂ زفثڋ malnutritionټفڌ ؼزبـ ڂ٬شڋ ثڅ

چٽفاڄ ثب ٬ځؽ ، دشبوڍٻ ڂ ټځڍكڌٻ ـا چٻ ڂاـؼ وٹڃٶ چب ټڋ ځؽ ڂ اڌٿ ټفڌ ڌٱؽ١٨څ ؼزبـ ٽجڃؼ اٸٱشفڂٸڍز ټڋ ڃؼ ڂ

fatalټڋ سڃاڀؽ re feeding syndromeؽ ٬ځؽ ـا سطٽٷ ځؽ . ؼزبـ چبڌذف اڀىڃٸڍځٽڋ ټڋ ڃؼ ڂ ڀٽڋ سڃاڀ سځڍٿچٽ

ثب ڀ٧ ټڍكاپ ٬ځؽ ټڃـؼ ټطبوجڅ ثڍٽبـ ـا اق ـڂق اڂٶ ثڃـر بټٷ ڀٽڋ ؼچڍٻ ثٹٱڅ ثبؽ، ثفاڊ خٹڃٴڍفڊ اق اڌٿ اس٩ب٪

ڂ ف٦ ؼڂ سب وڅ ـڂق آپ ـا بټٷ ټڋ ځڍٻ. فؼڄ فڂ

TPN therapy complications

• Electrolyte imbalance▫ Adjust the electrolytes in TPN based

on the lab abnormalities and available salts

• Adjust other fluid infusion rates if needed

• IV line infection/ bacteremia• Hypertriglyceridemia

Complication :

Electrolyte imbalance

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Discontinuation of TPN

• As soon as GI is functional considering D/C process

• Titrating the rate down to prevent electrolyte and glucose disturbances

• Titrate the TPN rate down by increasing the oral or enteral feeding tolerance

• May use cyclic TPN for a few days before discontinuation or in cases of long TPN therapy

ټڋ ځڍٻ. DCـا TPNڂ ڀڇبڌشب اڀدبٺ ؼچڍٻ tapering downثبڌؽ TPNثفاڊ ٬

" ڂ وذه ثب 75ڂ ٬ ټڋ ځڍؽ. ڌ١ځڋ اڂٶ ثب 1/3،1/2وب٠ز 72سب 48ـا ؼـ ٠ف TPNاڌٿ اوز څ ٽب ڌٯ ـاچٱبـ

50 "rate ځڍؽ.ڂ ڀڇبڌشب ٬ ټڋ

وب٠ز 12وب٠شڅ ثؽچڍٻ . ـڂقڊ 12ـا volumeټڋ ٴؿاـڌٻ ، ڌ١ځڋ ٷ ٨cyclicفٺ ؼڌٵف اڌٿ اوز څ ثڍٽبـ ـا ـڂڊ

TPN وب٠ز اق 12ڂGI اوش٩بؼڄ ڃؼ.اٴفGI tolerance ، ثڍٽبـ ثبال ـ٨زTPN ـاDC .ټڋ ځڍٻ

Summary

• Use GI first if it is functional

• If TPN is indicated

▫ Initial assessment

▫ Formulation

▫ Sterile admixture

▫ Administration

▫ Monitoring until D/C

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اڌفاپسدفثڍبر بـثفؼڊ س٥ؿڌڅ ڂـڌؽڊ ؼـ

ټؽـن:ؼشف ٠الء

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ثٵؿاـڌٻ . ٠ؽٺ اوش٩بؼڄ اق ـڂؼڄ وجت TPNثفاڊ ثڍٽبـڊ څ ڀٽڋ سڃاڀؽ اقـاڄ ـڂؼڄ اڊ ٤ؿا ؼـڌب٨ز ځؽ ټدجڃـ چىشڍٻ

ـڂؼڄ ، ٨ٹح ـڂؼڄ ڂ ڀڍكـؽ ټڍٱفڂثڋ ؼـ آپ ټڋ ڃؼ. integrityټٱالسڋ ڀڍف ثفچٻ غڃـؼپ

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وبڀشڋ ټشف 165ڍٹڃٴفٺ ڂ ٬ؽ 70وبٸڅ ثبڂقپ 59ثڍٽبـڊ څ ثفاڊ ڀٽڃڀڅ ټطبوجبر ثفاڌ اڀدبٺ ټڋ ڃؼ آ٬بڌڋ اوز

ـڂق ڀٽڋ سڃاڀؽ ٤ؿاثػڃـؼ 7-5ؽڄ ڂ اق قټبپ ثفؼاشٿ ټ١ؽڄ ثڅ ټؽر gasterectomyټ١ؽڄ خفاضڋ cancer، ثؽٸڍٷ

٬جٷ اق ٠ٽٷ دفوڍؽڄ ؽڄ ڂ اټٱبڀبر اڀؽاقڄ ٴڍفڊ آڀڇب ڂخڃؼ ڃؼ. $اال٠بر ٬ؽ ڂ ڂقپ ټفڌ اق غڃؼ ڂڊ TPNڂ ثبڌؽ

اڀفلڊ غڍٹڋ ؼ٬ڍ٫ ڀڍىز# estimationڀؽاـؼ ڂ ضؽڂؼڊ اوز ڂ ثڇٽڍٿ ؼٸڍٷ

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ثب ټطبوجډ ټڍكاپ اڀفلڊ ټڃـؼ ڀڍبق فڂ ټڋ ځڍٻ. چٽبڀڃـ څ ٬جال ثطث ؽ ڌٱڋ اق ـڂي چب اوش٩بؼڄ اق ـڂاث

Harris-Benedict . اڂٶ اوزBEE ـا ټطبوجڅ ټڋ ځڍٻ ، اڌٿ ٨فټڃٶ ثف اوبن ڂقپ ، ٬ؽ ، وٿ ڂ خځه اڀفلڊ دبڌڅ اڊ

BEEټڋ ځؽ. ثڃـ ټ١ٽڃٶ اٴف ٬ؽ ڂ ڂقپ ـا ڀؽاشڍٻ over estimateټڃـؼ ڀڍبق ـا ټطبوجڅ ټڋ ځؽ ،اڌٿ ٨فټڃٶ ا٤ٹت

لڊ ټڃـؼڀڍبق ٽشف ڂ چفزڅ ٬ؽ ڂ . ثف اوبن ٨فټڃٶ چف زڅ وٿ ٨فؼ ثبالسف اڀفڌٻفڍٴټڋ ؼـ ڀف kcal/kg 25-20ـا

ڂقپ ثڍشف اڀفلڊ ټڃـؼ ڀڍبق چٻ ثڍشف ټڋ ڃؼ.

٨بشڃـ چبڊ ١٨بٸڍز ڂ اوشفن ـا اب٨څ ټڋ ځڍٻ. چف ؽاٺ اق فاڌ ثڍٽبـ BEEـا ضىبة ټڋ ځڍٻ ڌ١ځڋ ثڅ TEEوذه

فڌجڋ غب ؼاـؼ څ ا٠ٽبٶ ټڋ ڃؼ.

ؼـ ، 28kcalـؼ ثڅ اڌٿ سفسڍت څ اٴف چڍر اوشفوڋ ڀجڃؼ ـڂي وبؼڄ سفڊ ثفاڊ ټطبوجډ اڀفلڊ ټڃـؼ ڀڍبق ڂخڃؼ ؼا

ث١ځڃاپ فڌت وٿ ؼـ ڀف ټڋ ٴڍفڌٻ kcal 40ڂ ثفاڊ اوشفن ؽڌؽ mild 30 kcal ،moderate 35k calاوشفن

$اوشفن ؽڌؽ ثؽٸڍٷ 35فة ؼـ 70ټب caseڅ ضبٷ اڌٿ فة ټڋ ڃؼ ټڍكاپ اڀفلڊ ټڃـؼ ڀڍبق ، ثفاڊ اڌٿ

څ ثبڌؽ ثڅ ڂڊ اڀفلڊ ثؽچڍٻ. kcal 2500ضؽڂؼ خفاضڋ# ټڋ ڃؼ

2100kcalڍٹڃٴفٺ # ټڋ ڃؼ چٽبپ 70فة ؼـ ڂقپ ثڍٽبـ $ kcal 35-30:اق ـڂي TEEضبٶ

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ثبڌؽ اق ٬ځؽ ، زفثڋ ڂ دفڂسئڍٿ سأټڍٿ ڃؼ . دفڂسئڍٿ ـا ځبـ ټڋ ٴؿاـڌٻ ڂ اق آپ ث١ځڃاپ ټځج اڀفلڊ ڍٹڃبٸفڊ2100اڌٿ

" زفثڋ ؼـ ڀف ټڋ ٴڍفڌٻ. ؼـ ثڍٽبـڊ څ ټٱٷ ؼاـؼ ، ثڅ 30" ٬ځؽ ڂ 70ځڍٻ. ټ١ٽڃال ثڃـ ڀفټبٶ اوش٩بؼڄ ڀٽڋ

ventilator ڂٷ اوز ڂ غڃؼي چٻ آوٽبسڍٯ اوز ټب و١ڋ ټڋ ځڍٻ اق ؼـؽ ٬ځؽ ٽشف اوش٩بؼڄ ځڍٻ ټثال ٬ځؽ ـا

" ڀىجز ثڅ زفثڋ ټڋ ؼچڍٻ.50ثڅ 50" ڂ ڌب ڀڇبڌشب 40ثڅ 60ثبڀىجز

اڀفلڊ سڃٸڍؽ ټڋ ځؽ ڂٸڋ اڌځدب ٬ځؽ ټب ثڃـر چڍؽـاسڅ kcal 4. چف ٴفٺ ٬ځؽ غبٸ 1470kcalټڋ ڃؼ 2100" اق 70

ٴفٺ ٬ځؽ ؼاـڌٻ . 432ڀڍبق ثڅ kcal 1470اڀفلڊ آقاؼ ټڋ ځؽ. ده ثفاڊ kcal 3.4اوز ڂ چف ٴفٺ آپ

ٴفٺ ، ده 490ڍٹڃڌڋ ټڋ ڃؼ 70اڊ ثڍٽبـ څ ثف gr/kg/day 7اوز ڂ ڌب mg/kg/min 5سكـڌ٫ ٬ځؽ rateضؽاثف

ټڍكاپ ټطبوجڅ ؽڄ ؼـ ټطؽڂؼڈ ټدبق اوز . ټ١ٽڃال چٻ اق ټ٭ؽاـ ټدبق ثڍشف ڀٽڋ ڃؼ.

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.ټبچؽڄ ټڋ ڃؼ څ ث١ب ثفاڊ ٴؿاشٿ ټڋ ڃؼ وڋ وڋ# 50ڂڌبٶ 17" $50اق ؼىشفڂق ml 864ٴفٺ ٬ځؽ 432

څ ؼـ Aminofusionڂ ڌٯ ٠ؽؼ ٠intralipidؽؼ ڂڌبٶ ؼىشفڂق ڌب چ٩شڅ اڊ ڌٯ ٠ؽؼ 2ڋ ٴڃڌځؽ ټ TPNثڍٽبـ ـڂڊ

ڂڌبٶ اال قڌبؼ ڀڍىز ڂ اٴف ثشؽـڌح ثفاڊ ثڍٽبـ فڂ ڃؼ ، اڀىڃٸڍٿ 17ټطبوجڅ ؽڄ چڍر ڀڍىز. kcal 2100ثفاثف

ڂڌبٶ ـا ڌٱؽ١٨څ ـڂق اڂٶ 17ؽ# . ټب چڍسٵبڄ ثڍٽبـ ڀڍك چٽذبڊ آپ ثبال آټؽڄ ڂ ٬ځؽ ـا ځشفٶ ټڋ ځؽ $اٴف ٨فؼ ؼڌبثشڋ ڀجب

ڂ چٽڍځڃـ ٻ ٻ اب٨څ ټڋ ځڍٻ. 9ث١ؽڊ ٠6ؽؼ ـڂق ث١ؽ 3ثڅ ثڍٽبـ ڀٽڋ ؼچڍٻ ثٹٱڅ ټثال ـڂق اڂٶ

" اوز .ټب ټدجڃـڌٻ 50ڌٯ ټٱٹڋ څ ټب ؼـ اڌفاپ ؼاـڌٻ ټفثڃ ثڅ ٠ؽٺ ڂخڃؼ ڂڌبٸڇبڊ ثب ضدٻ چبڊ ثبال اق ؼىشفڂق

ڂڌبٸڋ څ ڍڅ ، آٸڃټڍځڍٻ ڂ زىت آپ ڂاـؼاسڋ اوز ـا ؼڂـ ثفڌكڌٻ . چٽسځڍٿ ټطٷ وبغز 17څ ثفاڊ ڌٯ ثڍٽبـ ـڂقاڀ

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دفوشبـڊ stationڂڌبٶ ؼـ 17چٻ ثىڍبـ ټڇٻ ټڋ ڃؼ اٴف ٬فاـ ثبؽ ثبق فؼپ ڂ اوش٩بؼڄ اق اڌٿ TPNټطٹڃٶ

ثبڌؽ ؼـ TPNڅ ټطٹڃٶ ڃـر ٴڍفؼ ثڅ چٽبپ ټڍكاپ آٸڃؼٴڋ ثڅ وڍىشٻ اب٨څ ټڋ ڃؼ. ټٱٷ ؼڌٵف ټب ف٨ڋ اوز

آپ آټبؼڄ ڃؼ ټب ټدجڃـ چىشڍٻ وفٺ ؼڌٵفڊ ـا غبٸڋ فؼڄ ڂ اڌٿ ټطٹڃٶ چب ـا ؼاغٹ دف ځڍٻ څ ثبق ټىئٹډ اچٽڍز

20، 10ټطٷ وبغز اڌٿ ټطٹڃٶ چب ـا ڀبپ ټڋ ؼچؽ. ٴبچڋ ؼوشڃـ ټف٦ ثڃـر ؼـؽ اوز څ اڌٿ ٤ٹز چب $

وبغز څ ثبق چٻ ثؽٸڍٷ ٠ؽٺ ڂخڃؼ ټطٹڃٶ چب ثب ضدٻ ثبال ؼـ ٤ٹز "50"# ـاثبڌؽ ج٫ ٨فټڃٶ اق ؼىشفڂق 40، 30،

" ثب ضدٻ ثبال ټڃخڃؼ اوز#70چبڊ ټػشٹ٧ اوز. $ؼـ وبڌف ڃـ چب ضشڋ

ؼىشفڂق ڂچٽسځڍٿ ټڍكاپ اڂٸڍډ آپ ثبال ثبؽ ټڃخت چبڌذف ٴالڌىٽڋ ټڋ ڃؼ ، ٬ځؽ ثبال ټڃخت ؼ٨ آپ اق rateاٴف

ىشفڂق چٽفاڄ غڃؼ آة ـا ڀڍك اق ثؽپ ؼ٨ ټڋ ځؽ ڂ ثڍٽبـ ؼچڍؽـاسڅ ټڋ ڃؼ.ڂ ٹڍڅ چب ڂ ٴٹڍٱڃقڂـڊ ټڋ ڃؼ . ؼ

اوز څ ټب ثڍ اق gr/kg/h 1وف٠ز سدڃڌك ؼىشفڂقټٽٱٿ اوز ؼزبـ چبڌذف اوٽڃالـ ٽب ڃؼ.ټبكڌٽٻ

0.5grkg/h 35ڍٹڃڌڋ 70ڀٽڋ ؼچڍٻ څ ثفاڊ ثڍٽبـ gr /h ؼاؼ . ثبق وب٠شڅ 24، ثځبثفاڌٿ ثبڌؽ اڌٿ ټطٹڃٶ ـا ټڋ ڃؼ

اوز $ټثال TPNسأڍؽ ټڋ ڃؼ فڂ ؼاؼپ ٨فاڂـؼڄ ڂ ٬ آپ ثبڌؽ سؽـڌدڋ ثبؽ. اٴف ثؽاڀڍٻ ثڍٽبـ ټؽر ڃسبچڋ ـڂڊ

٠ٽٷ ټڋ ځڍٻ. partial PNثڃـر ڂ ڂڌبٶ 4سب3ـڂق# ټڍكاپ غڍٹڋ ٽشفڊ ثڅ ڂڊ ټڋ ؼچڍٻ 3

بپ ؼوشڃـ اڀىڃٸڍٿ ټڋ ؼچځؽ ؼـ ضبٸڋ څ اڌځدب ٬ځؽ ؼائٻ څ ؽ ثىڍبـڊ اق دكٱ 100سڃخڅ ؼاشڅ ثبڍؽ ٬ځؽ ثبالڊ

ـا ؼـ ڀفټڋ ٴڍفڌٻ. 200ټفش ڀڍىز ثځبثفاڌٿ FBSڂاـؼ خفڌبپ غڃپ ټڋ ڃؼ ڂ

" ؼـ ثبقاـ ثڍشف اوز. 10" ؼاـڌٻ ، ثڃـ ټ١ٽڃٶ 10ڂ Aminofusion 5ث١ؽ اق ٬ځؽ ڀڃثز دفڂسئڍٿ اوز.

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ثبؽ mildدفڂسئڍٿ ڀڍبق ؼا ـڌٻ څ ؼـ ڃـر ڂخڃؼ اوشفن اٴف RDAثڃـر gr /kg 0.8ؼـ ـڂق ټب ثڃـ ټ١ٽڃٶ

1gr/kg ڂ اٴفsevere 2-1.5ثبؽgr/kg 1.5ڍٹڃڌڋ ثب ڀڍبق 70ڀڍبق ـڂقاڀڅ دفڂسئڍٿ غڃاچؽ ثڃؼ . ثفاڊ ثڍٽبـ gr

/kg اق ټڍكاپ اڀفلڊ ټطبوجڅ ټڋ . ټڍكاپ دفڂسئڍٿ ٨بـ٢ ټڋ ڃؼ ټطبوجڅ ٴفٺ دفڂسئڍٿ ؼـ ـڂق 105ثؽٸڍٷ خفاضڋ

$ؼـ ضبٸڋ څ ؼـ ضبٶ ضبف Aminofusionوڋ وڋ# 500ڍڅ 2ٸڍشف $ 1ٴفٺ دفڂسئڍٿ س٭فڌجب ثفاثف ثب 105ڃؼ.

" ؼڂ 10ڂ 590mOsmol" ضؽڂؼ 5ٸڍشف . اوٽڃالـڌشڋ 2" ڌ١ځڋ ٠5ؽؼ ٠4ؽؼ ؼـ چ٩شڅ سدڃڌك ټڋ ځځؽ.# ڌب 2ث١ڋ چب

اوز. ثب سڃخڅ ثڅ peripheral 900ؽاثف اوٽڃالـڌشڋ ټدبق ثفاڊ سكـڌ٫ اق ـا اوز . ض mOsmol 1030ثفاثف ڌ١ځڋ

ټڋ ڃڀؽ اق چٽبپ اثشؽا سڃڍڅ ثڅ بـ TPNڅ آڀڇب چٻ ټڃخت ثبال ـ٨شٿ اوٽڃالـڌشڋ TPNڂخڃؼ ټڃاؼ ؼڌٵف ؼـ

چٻ ټڋ ؼاـاڊ اٸٱشفڂٸڍز Aminofusion + Eڅ ټطؽڂؼڌز اوٽڃالـڌشڋ ڀؽاـؼ ټڋ ڃؼ. $ټطڃٶ CVlineٴؿاشٿ

ثبؽ.#

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" ؼـ اڌفاپ ڀڍىز. چفؼڂ اڌكڂسڃپ چىشځؽ ڂ ټڋ سڃاڀڍٻ اق ـٲ ټطڍڋ ثڅ 20" ؼاـڌٻ څ 20ڂ Intralipid 10زفثڋ : ټب

چبڊ ټڃخڃؼ ؼـ ثبقاـ ثب قـؼڈ سػٻ ټف٢ $ٸىڍشڍٿ# ثڃـر اټڃٸىڍڃپ ؼـ آټؽڄ ، چف ڌٯ Intralipidثڍٽبـ ثؽچڍٻ . زڃپ

" اڀفلڊ ـا اق زفثڋ ثٵڍفڌٻ $ثفاڊ ثڍٽبـ ؼڌبثشڋ ڌب ثب ټٱٷ سځ٩ىڋ اڌٿ 30ؼچؽ . ٬فاـ ؽ اڀفلڊ ټڋ kcal 11ٴفٺ

ٸڍشفڊ $چف 0.5" ڌب ڌٯ ٠ؽؼ 572cc Intralipid 10 ټ١بؼٶڅ kcal 630" ټڋ ڃؼ 30ؼـؽ ټڋ سڃاڀؽ ثبالسف ـڂؼ# .

1cc ،1.1kcal اڀفلڊ ټڋ ؼچؽ(.

چب اوز. ٴبچڋ اڂ٬بر essential free fatty acidاڀفلڊ آپ sourceڀٱشڅ: ٨فاڂـؼڈ ٸڍذڍؽ اڌكڂسڃپ اوز ڂ ثڍشفڌٿ

٠ؽؼ 2ڌب 1ڀڍىز ثٹٱڅ ٤ؿا ټڋ غڃـؼ ڂٸڋ اڌٿ اوڍؽ زفة چبڊ فڂـڊ ٻ اوز ټٽٱٿ اوز TPNڅ ثڍٽبـ

Intralipid .ؼـ چ٩شڅ ٴؿاشڅ ڃؼ ڂ خبڌٵكڌٿ ټځبوجڋ ثفاڊ ا٨فاؼڊ اوز څ ټطؽڂؼڌز اوش٩بؼڄ اق ٬ځؽ ؼاـڀؽ

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ـڂ٤ٿ وڃڌب اوز څ بټٷ اوڍؽچبڊ زفة ٸڍځڃٸئڍٯ ، ٸڍځڃٸځڍٯ ، اڂٸئڍٯ ، دبٸٽڍشڍٯ ڂ اوشئبـڌٯ Intralipidزفثڋ

اوز.

ٽشفڊ CO2اوز ثځبثفاڌٿ زفثڋ 0.7ڂ ثفاڊ وڃغشٿ زفثڋ 1ڀىجز ؼڊ اىڍؽ فثٿ ثڅ اىڍمپ ثفاڊ وڃغشٿ ٬ځؽ

اڌدبؼ ټڋ ځؽ.

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Intralipid اٴف ڋ ؼـ دبڀٱفاسڍز ڀؽاـؼ زڃپ ڂ٬شڋ ڂاـؼ غڃپ ؽ سڃو ٸڍذبق چبڊ غڃڀڋ ټف٦ ټڋ ڃؼټځ ټف٨

ڀٽڋ سڃاپ ؼاؼ. قټبپ اڀدبٺ ڀٽڃڀڅ ٴڍفڊ ثفاڊ ٬بڂر طڍص Intralipid ثڃؼ 400ثڍٽبـڊ سفڊ ٴٹڍىفڌؽ اي ثبالڊ

ـاخ ثڅ وص سفڊ ٴٹڍىفڌؽ ثىڍبـ ټڇٻ اوز.

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: ٠Intralipidڃاـ

ثڍٽبـ ست ڂٸفق فؼ ڀبڀؽچځؽڈ ضىبوڍز اوز ڂ ثبڌؽ ٬ ڃؼ . سځٵڋ ڀ٩ه ، سڇڃ ڂ اوش٩فا٢ ، ؼـؼ ٴفؼپ ، ؼـؼ اٴف

اوز ؼـ اڌٿ چځٵبٺ ٴبچڋ بچ وف٠ز ڌب سدڃڌك ڌٯ ـڂق ؼـ Intralipidدز اڌځڇب چٽڅ ڂاځ چبڊ ضىبوڍشڋ ثڅ

ڀٵفاپ Aminofusionڂ Intralipidؼـ ټڃـؼ ټڋ ڃڌٻ. Intralipidټڍبپ ٽٯ ځځؽڄ اوز ڂٸڋ ٴبچڋ ټدجڃـ ثڅ ضؿ٦

وب٠ز اوز زڃپ ؼـ ٤ڍف ٬Intralipid 12 فؼپ ڀڍىشڍٻ ڂ ٨٭ ؼـ ټڃـؼ ٬ځؽ ټڇٻ اوز. ضؽاثف قټبپ سكـڌ٫

اڌدبؼ غڃاچؽ ؽ څ ټڃخت hyper triglyceridemiاڌځڃـر ثؽپ ٨فز ټف٦ اڌٿ ٸڍذڍؽ چب ـا ڀػڃاچؽ ؼاز ڂ

وب٠ز ثب٬ڋ ټبڀؽڄ ثبڌؽ ؼڂـ ـڌػشڅ 12چب ڂ ا٨كاڌ ـڌىٯ ٩٠ڃڀز ټڋ ڃؼ. ث١ؽ اق اڌٿ اغشالٶ ؼـ ٠ٽٹٱفؼ ڀڃسفڂ٨ڍٷ

ڃؼ.

ٽشف ثؽچڍٻ ، قڌفا غف سځح ڂ Intralipidثڃـ ٹڋ ثڅ ا٨فاؼڌٱڅ ٩٠ڃڀز ڌب اغشالالر اڀ١٭بؼڊ ؼاـڀؽ و١ڋ ټڋ ځڍٻ

ټٱالر ؼڌٵف ڂخڃؼ ؼاـؼ.

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ٻ ثبڌؽ ثڅ ـلڌٻ ثڍٽبـ اب٨څ ځڍٻ . ټشأو٩بڀڅ ٨ى٩بر ڂ اوشبر ١٨ال ؼـ اڌفاپ ڀؽاـڌٻ . ټڍكاپ ټڃـؼ ڀڍبق اٸٱشفڂٸڍز چب ـا چ

70ڍٹڃڌڋ س٭فڌجب 70وؽڌٻ اوز ثفاڊ ثڍٽبـ 1mEq" ضبڂڊ 5اڌځڇب ؼـ خؽاڂٶ چىز . س٭فڌجب چف وڋ وڋ وؽڌٻ ٹفاڌؽ

ثؽچڍٻ ثفاڊ 1mEq/kgدشبوڍٻ اوز ڂ زڃپ ثبڌؽ 2mEq" س٭فڌجب 51وڋ وڋ القٺ اوز. چف وڋ وڋ دشبوڍٻ ٹفاڌؽ

وڋ وڋ ٹف ټڃـؼ ڀڍبق چٻ اق اڌٿ ؼڂ سأټڍٿ ټڋ ڃؼ. ټځڍكڌٻ ڂ ٹىڍٻ چٻ ثفاڊ اڌٿ 35-30ڍٹڃڌڋ ټڋ ڃؼ 70ثڍٽبـ

وڋ وڋ القٺ اوز. 10-7ثڍٽبـ ضؽڂؼا ثڍٿ

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ټڍكاپ آة ټڃـؼ ڀڍبق ثڃـ ټ١ٽڃٶ ثفاثف اوز ثب :

Ml/day=1500 ml + (IBW-20) ×20

ٸڍشف 0.5ٸڍشف اق ؼىشفڂق ڂ Aminofusion ،1ٸڍشف اق 1. ټڋ ڃؼ lit/kg 35-30ٸڍشف ؼـ ـڂق ڌب چٽبپ 2.5څ س٭فڌجب

ٸڍشف ثڅ ضدٻ اب٨څ ټڋ ڃؼ ڂ 1" ثبؽ Aminofusion 5. اٴف ټڋ ڃؼ ٸڍشفټبڌ 2.5څ چٽبپ ؼاـڌٻ Intralipidچٻ

ٻ ثفاڊ ؼ٨ ټبڌ اب٨ڋ ٨ڃـقټبڌؽ ثڅ ټطٹڃٶ اب٨څ ځڍٻ. ؼـ ټڃاـؼڊ څ ټدجڃـڌٻ ټٽٱٿ اوز ټب ټدجڃـ ڃڌ

peripheral ثؽچڍٻ چٻ ٴبچڋ ټدجڃـ ټڋ ڃڌٻ ضدٻ ـا ثبال ثجفڌٻ. اٸجشڅ ثىشڅ ثڅ فاڌ ثڍٽبـ څ ټب ټطؽڂؼڌز ؼاشڅ

أټڍٿ ټڋ ځڍٻ.ټڋ ؼچڍٻ ڌ١ځڋ ٨٭ ڌٯ ټ٭ؽاـ اق اڀفلڊ ټڃـؼ ڀڍبق ـا س TPN ،Partial PNثبڍٻ ثڅ خبڊ

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ـا ثڅ ټطٹڃٶ اب٨څ ټڋ ځڍٻ ڂ ڂڌشبټڍځڇبڊ ټطٹڃٶ ؼـ آةڂڌشبټڍٿ چب : ؼڂ ڀڃ ټطٹڃٶ ؼـ آة ڂ زفثڋ ؼاـڌٻ څ

ڋ ځڍٻ. اٴف دالز ټفڌ دبڌڍٿ اوز ثڃـر ٠الڀڋ سكـڌ٫ ټ A,E,Dټطٹڃٶ ؼـ زفثڋ ـا څ بټٷ ڂڌشبټڍځڇبڊ

ـا ثبڌؽ Kثبؽ ڀٽڋ سڃاپ اڌٿ سكـڌ٫ چبڊ ټٱفـ ـا اڀدبٺ ؼاؼ ڂٸڋ ا٤ٹت ټفڌ چب ټٱٹڋ اق اڌٿ خڇز ڀؽاـڀؽ. ڂڌشبټڍٿ

خؽاٴبڀڅ ټف٦ ځڍٻ. اٴف ثڍٽبـ فڂ ثڅ اوش٩بؼڄ اق ـڂؼڄ اي فؼ ټڋ سڃاپ ټڃٸشڋ ڂڌشبټڍٿ چب غڃـاڋ ڀڍف

centrum ڂ ڌبgeriatric pharmaton ڌب ټڃٸشڋ ټڍځفاٶ اوش٩بؼڄ فؼ اق ټڃٸشڋ سفادڍڃسڍٯ ثؽٸڍٷ ؼڂق چبڊ ثبال ٽشف

اوش٩بؼڄ ټڋ ڃؼ.

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Trace element سب ځڃپ ټب :Trace element سكـڌ٭ڋ ڀؽاشڍٻ. اٴف ڃٶTPN 5ـڂق ڂ سب ضؽاثف 3-2ڃسبڄ ثبؽ

ؽر ثبڌؽ ضشٽب ثڅ ثڍٽبـ ثؽچڍٻف٦ ڀف فؼ ڂٸڋ ؼـ ڃالڀڋ ټ Trace elementـڂق ټڋ سڃاپ اق

" اب٨څ فؼ ڂ ټٱٹڋ ڀؽاـؼ اڀىڃٸڍٿ $ثب چٽبپ ڍڃڈ سڃڍص ؼاؼڄ ؽڄ 50ثىڍبـڊ اق ټڃاؼ ـا ټڋ سڃاپ ثڅ ؼىشفڂق

، #H2 . ثالف ټبڀځؽ ـاڀڍشڍؽڌٿ $ثػبف اوشفن اڂٸىف# ، چڍؽـڂڃـسڍكڂپ ڂ آټڍځڃ ٨ڍٹڍٿ

ثڃؼ ټڋ سڃاپ ـڌػز compatibleچفزڅ Aminofusionڀفڌكڌؽ! ؼـ ؼىشفڂق ڂ چڍر زڍك Intralipidڀٱشډ ټڇٻ: ؼـ

ثؽٸڍٷ اضشٽبٶ ٱىشٿ اټڃٸىڍڃپ ڂ اڌدبؼ آټجڃٸڋ زفثڋ زڍكڊ ڀجبڌؽ ـڌػشڅ ڃؼ. Intralipidڂٸڋ ؼـ

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ثفاڊ ټبڀڍشڃـڌٳ څ ج٫ خؽڂٶ ٠ٽٷ ټڋ ڃؼ.

س٭ىڍٻ ځڍؽ ڂ ؼـ 150ٴف ټڍكاپ بٸفڊ ټڃـؼ ڀڍبق ـا ثف ڀٱشڅ : ثفاڊ ټطبوجډ دفڂسئڍٿ ـڂي ؼڌٵفڊ ڀڍك ڂخڃؼ ؼاـؼ . ا

ٴفٺ 6س٭فڌجب kcal 150فة ځڍٻ ټڋ ڃؼ ټڍكاپ دفڂسئڍځڋ څ ثڍٽبـ ڀڍبق ؼاـؼ ڂ ؼـ ڂا٬ ټڋ ٴڃڌڍٻ ثڅ اقاڊ چف 6.25

دفڂسئڍٿ ڀڍبق اوز.

١بؼٶ اٸٱشفڂٸڍز چب ، سفڂټجڃ٨ٹجڍز ڂ ثفچٻ غڃـؼپ س Pneumothoraxټڋ سڃاپ ثڅ ـڌىٯ ٩٠ڃڀز ، TPNاق ټٱالر

ابـڄ فؼ.

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تغذیه وریدی در اطفبل

مدرس:دکتز جهبنگزد

چىشځؽ اق ڀف ؼـڌب٨ز ټڃاؼ س٥ؿڌڅ اڊ ثىڍبـ ثبڌؽ pretermڀڃقاؼاڀڋ څ ثب ڂقپ ثىڍبـ ٻ ثؽڀڍب ټڋ آڌځؽ ڌب ؼـ ڂا٬

ڃڀؽ ټڋ سڃاڀؽ ؼـ ـؽبپ سأثڍف قڌبؼڊ ؼاشڅ ثبؽ ڂ deficientچٻ اٴف ڃخڅ ڂا٬ ڃڀؽ ، زڃپ ثڅ ټ٭ؽاـ ٻټڃـؼ س

ؼـ اڌٿ ڀڃقاؼاپ ټڋ سڃاڀؽ اڌٿ بچ Nutrition parenteral ڂقپ قڌبؼڊ ـا اق ؼوز ثؽچځؽ ، ثڅ چٽڍٿ ؼٸڍٷ اوش٩بؼڄ اق

full termس٥ؿڌډ ب٨ڋ ؼـ ڀڃقاؼڊ څ ـڂق 5ثڍ اق ڂقپ ـا ثڅ ضؽا٬ٷ ثفوبڀؽ ڂ ؼـ ض٭ڍ٭ز ٴ٩شڅ ټڋ ڃؼ څ اٴف ټب

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ڀٵڍفؼ ټڋ سڃاڀؽ ٠ڃا٬جڋ ـا ثڃخڃؼ ثڍبڂـؼ څ بڌؽ خجفاپ ـڂق س٥ؿڌڅ 3ثڍ اق pretermڀڃقاؼ اوز ڀؽاشڅ ثبڍٻ ڌب

.ڀبدؿڌف ثبؽ

ڀڃقاؼاپ: TPNټڃاـؼ اڀؽڌٱبوڍڃپ

ثؽڀڍب ټڋ آڌؽ . 1000grچ٩شڅ ڌب ڀڃقاؼڊ څ ثب ڂقپ ٽشف اق 30قاڌٽبپ ٽشف اق

ڋسځ٩ىثبؽ ڂ ټٱٷ Broncho pulmonary dysplasiaچ٩شڅ اٴف ڀڃقاؼ ؼزبـ ؼڌىشفن سځ٩ىڋ ڌب 30ثڍ اق قاڌٽبپ

ثفاڌبپ اڀدبٺ ڃؼ. TPN ثبڌؽ ؼاشڅ ثبؽ . اڌٿ ڀڃقاؼاپ چٻ زڃپ ثڅ ؼوشٵبڄ ڂٷ ټڋ ڃڀؽ ،

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اڀفلڊ ؼاشڅ ثبؽ. sourceټٽٱٿ اوز ڀڃقاؼ ـؽ ؼاغٷ ـضٽڋ ٽڋ ؼاشڅ ثبؽ ڂ ڂ٬شڋ ثؽڀڍب ټڋ آڌؽ ڀڍبق ثڅ ڌٯ

ؼـ اڌٿ ثڍٽبـڊ چٻ سڃڍڅ ټڋ ڃؼ څ ـڂؼڄ ڂ ؼوشٵبڄ necrotizing entrocolitisثڍٽبـڊ بڌ١ڋ ڂخڃؼ ؼاـؼ ثڅ ڀبٺ

اوز. TPNٴڃاـي ڀڃقاؼ اوشفاضز ځؽ ڂ س٥ؿڌڅ اق ـاڄ غڃـاڋ ثڅ ڂڊ ڀٽڋ ؼچڍٻ. ڌٱڋ اق ـڂڇبڊ ؼـټبڀڋ اوش٩بؼڄ اق

بٶ خفاضڋ ټثال اڀىؽاؼ ـڂؼڄ ؼاـؼ ڌب اوڇبٶ غڍٹڋ ؽڌؽ ؼاـؼ څ ڀٽڋ سڃاڀؽ ٤ؿا ـا ثڅ ؼـ ټڃاـؼڊ څ ڀڃقاؼ ڀڍبق ثڅ ا٠ٽ

دڍ ټڋ آڌؽ. TPNڃـر غڃـاڋ ټف٦ ځؽ چٻ خكء ټڃاـؼڊ اوز څ ڀڍبق ثڅ

اڌٿ اوز څ بٸفڊ ب٨ڋ ڂ ټڃاؼ س٥ؿڌڅ اڊ ب٨ڋ ـا ؼـ چ٩شڅ اڂٶ قڀؽٴڋ ڌٯ ڀڃقاؼ ڀبـن ثڅ ڂڊ TPNچؽ٦ ټب اق

ټڋ سڃاڀؽ بچ TPNڀڍٻ سب اق ٠ڃاـ ؼائٽڋ څ ټٽٱٿ اوز ثفاڊ ڀڃقاؼ ثڅ ڂخڃؼ ثڍبڌؽ خٹڃٴڍفڊ ځڍٻ. اڀدبٺ ثفوب

ڂقپ ڀڃقاؼ ـا ثڅ ضؽا٬ٷ ثفوبڀؽ ڂ ثب ـوبڀؽپ دفڂسئڍځڇبڌڋ څ ڀڃقاؼ ثفاڊ ـؽ ټ٥كڊ ثڅ آڀڇب ڀڍبق ؼاـؼ اق ٠٭ت ا٨شبؼٴڋ

ؾچځڋ ڀڃقاؼ خٹڃٴڍفڊ ځؽ.

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ثكـٴىبالپ اوش٩بؼڄ ټڋ ځڍٻ اق TPNاؼاپ ڂخڃؼ ؼاـؼ س٭فڌجب جڍڅ ټڃاؼڊ اوز څ ؼـ ڀڃق TPNټڃاؼڊ څ ؼـ

ثب وف٠ز ڂ ـا ځڍٻ ثب اڌٿ س٩بڂر څ فثڃچڍؽـاراوش٩بؼڄ ټڋ energy sourceثڅ ٠ځڃاپ intra lipidفثڃچڍؽـار ڂ

فڂـڊ ڂ ڀڍك آټڍځڃ اوڍؽچبڌڋ . دفڂسئڍځڋ څ ثڅ ڀڃقاؼاپ ټڋ ؼچڍٻ ثبڌؽ ضشٽب آټڍځڃ اوڍؽچبڊټڋ ؼچڍٻ ټ٭ؽاـ ثڍشفڊ

چب trace elementـا څ جؽ اڌٿ ڀڃقاؼاپ سڃاڀبڌڋ سڃٸڍؽبپ ـا ڀؽاـڀؽ، ـا ثڅ ڀڃقاؼ ثفوبڀؽ. اٸٱشفڂٸڍشڇب، ڂڌشبټڍٿ چب ڂ

ڀڃقاؼاپ ثبڌؽ ڂخڃؼ ؼاشڅ ثبؽ. TPNچٻ ؼـ

څ اڌٿ ـڂي قټبڀڋ سڃڍڅ ټڋ ڃؼ اوز ټبڀځؽ ثكـٴىبالپ peripheralؼـ ڀڃقاؼاپ ڌب ثڅ ڃـر TPNـڂي سدڃڌك

چ٩شڅ ٬فاـ اوز ڃٶ ثٱؽ ڂ ڀڍك ټطؽڂؼڌز ؼاؼپ ټبڌ ڂ 2ڃسبڄ ثبؽ ڂٸڋ اٴف ثڍشف اق nutritionڅ ټؽر قټبپ

اوٽڃالـڌشڅ ثڅ ڀڃقاؼ ؼاـڌٻ ثبڌؽ ضشٽب اق ـٲ ټفكڊ اوش٩بؼڄ فؼ.

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Case: ؼزبـ ڂ ؼڀڍب آټؽڄ ثڅ ڍٹڃٴفٺ 3/1ثب ڂقپ 28ؼـ چ٩شڅ ڀڃقاؼڊdistress سځ٩ىڋ اوز ڂ ثڅ ؼوشٵبڄ ڂٷ اوز

ثفاڌ اڀدبٺ ؼچڍٻ. TPNڂ ضبال ټب ڀڍبق ؼاـڌٻ

ټطبوجبر:

ؼـ ټفضٹڅ اڂٶ ثبڌؽ ټڍكاپ اڀفلڊ څ ڀڃقاؼ ڀڍبق ؼاـؼ ـا ټطبوجڅ ځڍٻ. ڀڃقاؼ ٠الڂڄ ثف ڀڍبقچبڊ ټشبثڃٸڍٯ اڂٸڍڅ ڂ دبڌڅ اڊ

ڊ ـؽ ڀڍبق غڃاچؽ ؼاز ڂ اڌٿ س٩بڂسڋ اوز څ ثب ثكـٴىبالپ ؼاـؼ. اق ڀف سفڍجڋ ثب څ ؼاـؼ ټ٭ؽاـڊ اڀفلڊ ڀڍك ثفا

اق ـا "30" اق دفڂسئڍٿ ڂ 15-10اق فثڃچڍؽـار، اڀفلڊ " 60ثكـٴىبالپ غڍٹڋ س٩بڂسڋ ڀٽڋ ځؽ ڌ١ځڋ و١ڋ ټڋ ځڍٻ

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fat ڃقاؼ سبټڍٿ ځڍٻ. ټڍكاپ بٸفڊ څ دفڂسئڍٿ ثڅ ټب ټڋ ؼچؽ ـا ؼـ ټطبوجبر ؼغڍٷ ټڋ ځڍٻ. ڌٯ ڀpreterm ضؽڂؼ

kcal/kg/day90-120 100ڍٹڃٴفٺ ڂقپ ؼاـؼ اڌٿ ټ٭ؽاـ ـا 3/1ڀڍبق ثڅ اڀفلڊ ؼاـؼ څ ټب ثفاڊ ڀڃقاؼ ټڃـؼ ڀف څ

اوز. kcal 130ؼـ ڀف ٴف٨شڍٻ ثځبثفاڌٿ ڀڍبق ـڂقاڀڅ ڂڊ

ثىشڅ ثڅ فاڌ ټطڍڋ اوز څ ڀڃقاؼ ؼـ ټفضٹڅ ؼڂٺ ثبڌؽ ټڍكاپ ټبڌ١بر ؼـڌب٨شڋ ڂ ټڃـؼ ڀڍبق ڂڊ ـا ضىبة ځڍٻ. اڌٿ

ؼـ آپ ٬فاـ ؼاـؼ. اٴف ټطڍ افا٦ ڀڃقاؼ ؼـ ـڂق اڂٶ غڍٹڋ ټفڃة اوز ثڅ ټڍكاپ ٽشفڊ ثڅ ټبڌ١بر اضشڍبج دڍؽا ټڋ

ټطڍ غٱشف اوز اڌٿ ټ٭ؽاـ ثڍشف ؽڄ ڂ ثڅ ڃـ ؼـ ڀف ټڋ ٴڍفڌٻ. اټب اٴف ml/kg 100-60ځؽ ثڅ ڃـ ٹڋ

ml/kg/day 180-120ځؽڄ اڌٿ ټ٭ؽاـ ـا ا٨كاڌ ټڋ ؼچڍٻ ڂ ٴ٩شڅ ټڋ ڃؼ څ اڌٿ ڀڃقاؼ ڀڍبق ثڅ ټشڃو ؼـ ـڂقچبڊ آڌ

ؼاـؼ. ټبڌ١بر

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ٴفٺ ؼـ ـڂق ثفاڊ ـڂقچبڊ اڂٶ 3-2ټفضٹڅ ث١ؽ ټطبوجڅ دفڂسئڍٿ اوز سڃڍڅ ټڋ ڃؼ څ آټڍځڃ اوڍؽچب ثب ټ٭ؽاـ

اوز pretermؼـ ڀڃقاؼڊ څ g/kg 4اوز ڂ termؼڊ څ ؼـ ڀڃقا g/kg 3فڂ ڃؼ ڂ وذه سب ټڍكاپ ضؽاثف

اڀفلڊ ثفاڊ ڀڃقاؼ ضىبة ټڋ ځڍٻ. sourceا٨كاڌ ڌبثؽ. چٽبڀٽڃـ څ ٴ٩شڅ ؽ ټب دفڂسئڍٿ ـا خكء

ڀڃقاؼ اب٨څ ڃؼ وڍىشئڍٿ اوز. اڌٿ اوڍؽ آټڍځڅ فڂـڊ ڀڍىز اټب ثفاڊ TPNڌٱڋ اق ټڃاؼڊ څ ثبڌؽ ضشٽب ثڅ

آڀڇب اق ـڂق وڃٺ اب٨څ ڃؼ. ټ٭ؽاـ TPNاڀبڌڋ وبغز آپ ـا اق ټشڍڃڀڍٿ ڀؽاـؼ ضشٽب ثبڌؽ ثڅ ڀڃقاؼاپ زڃپ جؽبپ سڃ

ثڅ اقاڊ چف ٴفٺ آټڍځڃ اوڍؽڊ اوز څ ثفاڊ ڀڃقاؼ ثڅ ٨فټڃٶ اب٨څ ټڋ ځڍٻ mg 30آپ

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اـڀؽ اڌٿ اوز څ زڃپ كـٴىبالپ ؼقاؼ ـا ضىبة ځڍٻ. س٩بڂسڋ څ ثب ثؼـ ټفضٹڅ ث١ؽ ثبڌؽ ټڍكاپ ؼىشفڂق ؼـڌب٨شڋ ڀڃ

جؽبپ ٬بؼـ ثڅ آقاؼ فؼپ ٴٹڃك اق ٴٹڍٱڃلپ ڀڍىز ڀڍبقبپ ثڅ ٬ځؽ ثڍشف اوز ڂ وف٠ز سدڃڌك ٬ځؽ چٻ ثڍشف اوز.

mg/kg/min 8ټڋ سڃاڀڍٻ ثؽچڍٻ. ڂٸڋ ؼـ ڃؼبپ سب mg/kg/min 5ؼـ ثكـٴىبالپ چٽبڀڃـ څ ٴ٩شڅ ؽ ضؽاثف ټب

ؼٸڍٷ اڀدبٺ ټڋ ڃؼ اڂٶ اڌځٱڅ ٴٹڃك ټڇٽشفڌٿ ټځج اڀفلڊ ټ٥كڊ ثفاڊ ڀڃقاؼاپ ثڅ چٻ ټڋ سڃاڀڍٻ ثؽچڍٻ. اڌٿ بـ ثڅ وڅ

ضىبة ټڋ آڌؽ ڂ زڃپ ڀىجز ڂقڀڋ ټ٥ك ڀڃقاؼ ثڅ ثب٬ڋ ثؽپ ڀىجز ثڅ ثكـٴشفچب ثڍشف اوز ده ڀڍبق ثڅ ٴٹڃكي چٻ

لڀك ٴٹڃك سڃٸڍؽ ځځؽ. ثڍشف اوز. اق ف٨ڋ ؾغڍفڄ زفثڋ ؼـ ثؽپ ڀڃقاؼاپ ڂخڃؼ ڀؽاـؼ څ ثشڃاڀځؽ اق فڌ٫ ٴٹڃڃڀئڃ

چٽسځڍٿ ثڅ ؼٸڍٷ ټٱالسڋ څ ڀڃقاؼ ؼاـؼ ثڇشف اوز ټځج اڀفلڊ ثڍشف ٬ځؽ ثبؽ ڀڅ زفثڋ.

ټڋ ـوبڀڍٻ ڂ ج٫ ټطبوجبر mg/kg/min 12فڂ ڂ ڋ ـڂقچبڊ آڌځؽڄ ثڅ mg/kg/min 8وف٠ز ثب ؼىشفڂق ـا

" القٺ ؼاـڌٻ.50ؼىشفڂق ml 24ثفاڊ ڀڃقاؼټبپ

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ؽ ٸڍذڍؽ ـا ثفاڊ ڀڃقاؼ ضىبة ځڍٻ. اڌٿ ٸڍذڍؽ چٻ اوڍؽچبڊ زفة فڂـڊ ـا ثڅ ثؽپ ڀڃقاؼ ټڋ ـوبڀؽ ؼـ ټفضٹڅ ث١ؽ ثبڌ

ثڅ ـلڌٻ ٤ؿاڌڋ ڀڃقاؼ اب٨څ g/kg/day 1ثب ټڍكاپ ٸڍذڍؽ ـا ڂ چٻ ټځج اڀفلڊ ٤ڍف دفڂسئڍځڋ ثفاڊ ڀڃقاؼ اوز. ټ١ٽڃال

6.5ثفوبڀڍٻ. ثب ټطبوجبر ثڅ زڍكڊ ضؽڂؼ g/kg/day 3ټڋ ځڍٻ ڂ چؽ٦ ټب اڌٿ اوز څ آپ ـا ؼـ ـڂقچبڊ آڌځؽڄ ثڅ

ml ڀڍبق ؼاـڌٻ.20ٸڍذڍؽ "

چبڊ ٬referenceؽٺ ث١ؽڊ ټطبوجڅ اٸٱشفڂٸڍشڇبوز. ثفاڊ ڀڃقاؼاپ ڂ ڃؼبپ ؼـ چف وځڋ خؽاڂٸڋ ڂخڃؼ ؼاـؼ څ ؼـ

قپ ڀڃقاؼ، ڀڍبق ـڂقاڀڅ اي ـا ټػشٹ٧ ٬بثٷ ؼوشفوڋ اوز ڂ ڀڍبقڊ ثڅ ض٩ فؼپ ڀؽاـؼ. اڌٿ خؽاڂٶ ثفاوبن وٿ ڂ ڂ

س٭ىڍٻ ثځؽڊ فؼڄ اڀؽ.

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ثفاڊ ڀڃقاؼڊ ثب ،ڂخڃؼ ؼاـؼ ثفاڊ ڀڃقاؼاپ ڀبـنڂڌشبټڍٿ چبوز. ټڃٸشڋ ڂڌشبټڍٿ چبڌڋ څ اب٨څ فؼپ ټفضٹڅ ث١ؽڊ

ڋ ثڅ ـلڌٽبپ اب٨څ ټ ml 5ڍٹڃٴفٺ، 5/2ڂ ثفاڊ ڀڃقاؼاپ ثڍ اق ml 2ڍٹڃٴفٺ زڍكڊ ضؽڂؼ 5/2ڂقپ ٽشف اق

ځڍٻ.

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٨٭ قڌځٯ ڂ وٹځڍڃٺ اق اثشؽا ثڅ ـلڌٻ ڃؼٮ اب٨څ ټڋ ڃؼ ڂ ث٭ڍڅ ڀڍف .چب ـا ؼاـڌٻ trace elementؼـ ڀڇبڌز

ټځٵځك، ټه ڂ فٺ ثفاوبن ڀڍبق ؼـ ـڂقچبڊ آڌځؽڄ اب٨څ ټڋ ڃؼ. ؼـ ڃـسڍٱڅ ڃؼٮ ؼزبـ ٹىشبق ثبؽ سڃڍڅ

ٿ ڌڃڀڇب جؽڊ اوز. اٴف ڀبـاضشڋ ٹڍڃڊ ؼاشڅ ثبؽ سڃڍڅ ټڋ ټڋ ڃؼ څ ټه ڂ ټځٵځك اب٨څ ڀڃؼ زڃپ ؼ٨ اڌ

ڃؼ وٹځڍڃٺ ڂ فٺ اق ـلڌٻ ضؿ٦ ڃؼ.

اق ټڃاؼڊ څ ؼـ اوالڌؽچبڊ ٬جٷ ؼڌؽڌٻ ؼاـڌٻ څ ثڅ ثؽپ ڃؼٮ ثفوبڀڍٻ. ml 82ؼـ ڀڇبڌز ثب ټطبوجبسڋ څ ؽ ضؽڂؼ

آة اوشفڌٷ ثڅ ټػٹڃ اب٨څ ټڋ ځڍٻ. ml 113ثڃؼ څ ثفاوبن آپ ml 195ټڍكاپ ضدٽڋ څ ڀڃقاؼ القٺ ؼاز

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ثڅ اڌٿ ڃـر اوز څ اق ڌٯ الڌٿ ټب آټڍځڃ اوڍؽ، ؼىشفڂق ڂ اٸٱشفڂٸڍشڇب ـا سكـڌ٫ ټڋ ځڍٻ ڂ اق الڌٿ ؼڌٵف سدڃڌك

66وب٠ز سكـڌ٫ ڃڀؽ. ج٫ ټطبوجبسڋ څ اڀدبٺ ؼاؼڌٻ ؼـ ـڂق اڂٶ ٨٭ 24ٸڍذڍؽ ـا ڂ چف ؼڂڊ اڌځڇب ثبڌؽ ؼـ ٠ف

kcal ـا ا٨كاڌ ټ٭ؽاـ اڀفلڊ ثڅ ثؽپ ڀڃقاؼ ټڋ ـوؽ ڌ١ځڋ ڀ٧ آپ ټ٭ؽاـڊ څ ڀڍبق ؼاـؼ ڂ ټب ڋ ـڂقچبڊ آڌځؽڄ اڌٿ

ټڋ ؼچڍٻ.

0.5ټڋ ـوبڀڍٻ. ٸڍذڍؽ ـا اق ـڂق چ٩شٻ ثب وف٠ز mg/kg/min 12ٴٹڃك ـا ثڅ سؽـڌح ا٨كاڌ ټڋ ؼچڍٻ ڂ ضؽاثف ثڅ

g/kg/day 3ا٨كاڌ ټڋ ؼچڍٻ ڂ ثڅ g/kg/day چؽ٨ڋ څ ټڍكاپ اڀفلڊ ـوبڀڍٻ ثب اڌٿ ا٨كاڌڇب ف٦ زځؽ ـڂق ثڅټڋ

ثفاڊ ڀڃقاؼ ڀڍبق ؼاشڍٻ ټڋ ـوڍٻ.

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ڀٱبر:

وب٠ز اوز ڂ ضدٻ غڍٹڋ ٽڋ ؼـ وب٠ز سكـڌ٫ ټڋ ڃؼ، ضشٽب 24زڃپ وف٠ز سكـڌ٫ اڌٿ ٨فآڂـؼڄ چب ثفاڊ ڀڃقاؼ

ټ١ٽڃال سڃڍڅ ټڋ ڃؼ ڀڍٻ سب ڌٯ ـٲ ڂ الڌٿ ض٩ ڃؼ. patencyآڀڇب اب٨څ ڃؼ سب TPNثبڌؽ چذبـڌٿ ثڅ ټطٹڃٶ

ڂاضؽ ؼـ ـڂق اوز. 137 ـڌٿ سڃڍڅ ؽڄ چذب اب٨څ ڃؼ ڂ ضؽاثف TPNڂاضؽ ؼـ ټڍٹڋ ٸڍشف، چذبـڌٿ ثڅ ټطٹڃٶ

ټبؼڄ ؼڌٵفڊ څ ثڅ ـلڌٻ ڀڃقاؼاپ اب٨څ ټڋ ڃؼ، بـڀڍشڍٿ اوز. زڃپ ڀڃقاؼاپ ڀبـن ؼـ ـڌىٯ بچ بـڀڍشڍٿ ٬فاـ

اق چ٩شڅ ؼڂٺ اڌٿ ټبؼڄ ـا ؼـڌب٨ز ځؽ. mg/kg/day 20-10اپ ؼاـڀؽ. سڃڍڅ ټڋ ڃؼ ثڅ ټڍك

ټبڀڍشڃـڌځٳ ڀڍك س٩بڂر قڌبؼڊ ثب ڌكـٴىبالپ ڀؽاـؼ. اٸٱشفڂٸڍشڇبڊ غڃڀڋ ڌ١ځڋ وؽڌٻ، دشبوڍٻ، ٹفاڌؽ ڂ ثڋ فثځبر ڂ

٨ز اڀفلڊ ټڋ سڃاپ اق ٸطب ؼـڌب TPNؽپ ڀڃقاؼ ڂ بټٷ ؽپ stableچٽسځڍٿ ٴٹڃك ثبڌؽ ـڂقاڀڅ زٯ ڃؼ. ده اق

، فاسڍځڍٿ، ٹىڍٻ، ٨ى٩ف، ټځڍكڌٻ، آٸٱبٸڍٿ ٨ى٩بسبق، سىشڇبڊ جؽڊ ڂ BUNؼـ ڀڇبڌز سڃاسف اڀؽاقڄ ٴڍفڊ ـا بچ ؼاؼ.

سىشڇبڊ اؼـاـڊ ثفاڊ ؼ٨ ٬ځؽ، اق سىشڇبڌڋ اوز څ اڀدبٺ ټڋ ڃؼ.