K-6 Pendahuluan Patologi Anatomi
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Transcript of K-6 Pendahuluan Patologi Anatomi
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DEPARTEMEN PATOLOGI ANATOMIFAKULTAS KEDOKTERAN UNIVERSITAS SUMATERA UTARA
MEDAN2011
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Tim Pelayanan Medik
2DEPARTEMEN PA USU 2011
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PATOLOGI
3DEPARTEMEN PA USU 2011
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PATOLOGI
4DEPARTEMEN PA USU 2011
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PATOLOGI ANATOMI
Merupakan suatu ilmu yang mempelajari tentang
perubahan struktur dan fungsi dari organ / jaringan / sel
yang terkena penyakit / jejas yang merugikan.
5DEPARTEMEN PA USU 2011
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ASPEK PROSES PENYAKIT
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PATOLOGI ANATOMI
Mempelajari:• Struktur / morfologi• Fungsi :
– Sel– Jaringan– Organ
• Hubungan kelainan dengan gejala klinik yang timbul
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PATOLOGI ANATOMI
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Pembagian Patologi
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Pemeriksaan di LabORATORIUM PA
Sel(Sitopatologi)
Jaringan(Histopatologi)
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PATOLOGI ANATOMI
Makroskopis (“Gross appearance”)
Mikroskopis
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Pengiriman Jaringan
Histopatologi
Sitologi
Operasi: laparatomi, radikal
mastektomi
Frozen section / Potong Beku
Biopsi
Eksisi
Si-Bajah
Cairan; pleura, sputum, BAL
Scrapping
Imprint Hasilnya:
• Menegakkan diagnosa
• Menentukan prognosa
• Rencana pengobatan
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BiopsiPengambilan jaringan / sel dari
organisme yang hidup untuk diperiksa di bawah mikroskop
Pengambilan jaringan / sel dari organisme yang hidup untuk diperiksa
di bawah mikroskop
Tujuan
Untuk diagnosa terhadap sampel jaringan tersebut
Untuk diagnosa terhadap sampel jaringan tersebut
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Teknik biopsi
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Surgical breast biopsy
Departemen PA FK-USU 2011
http://en.wikipedia.org/wiki/File:Surgical_breast_biopsy.jpg
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Brain biopsy under stereotaxy
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Liver core needle biopsy.
Departemen PA FK-USU 2011
http://en.wikipedia.org/wiki/Biopsy
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Biopsi jaringan
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Biopsi insisional(Makroskopis)
Karsinoma sel skuamous
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Biopsi insisional Leukoplakia
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21DEPARTEMEN PA USU 2011
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Tindakan merendam bahan yang berasal dari biopsi, operasi / autopsi ke dalam cairan fiksasi (volume cukup dan cairan fiksasi yang benar)
1. Mencegah terjadinya proses autolisis
2. Mencegah proses pembusukan
3. Memadatkan & mengeraskan agar mudah untuk dipotong
4. Memadatkan cairan koloid
5. Mencegah kerusakan struktur jaringan
TUJUAN
Fiksasi:
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Cairan fiksasi untuk pemeriksaan histopatologi:
• Formaldehid*• Etil alkohol• Asam asetat• Asam pikrat • Zenker• Bouin*• Carnoy, dll
* umum digunakan karena mudah didapat, cukup murah & hasil
fiksasi cukup memuaskan & sudah lazim digunakan
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Cara melakukan fiksasi jaringan
Massa tumor
Cairan fiksasi
15-20 x vol jaringan atau jaringan yang difiksasi terendam
Pada botol yang berisi jaringan yang difiksasi dicantumkan identitas pasien
Pada surat pengantar pengiriman jaringan sertakan identitas pasien & keterangan klinis.
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Sediaan
Histopatologi
Sitologi
Fiksasi : Formalin, Bouin, Zenker, dll
Staining : pewarnaan rutin HE
Fiksasi (+) : Alkohol 96%, 50%
Staining : HE, Papanicolaou
Fiksasi (-) : dry smear
Staining : Giemsa
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(10-20 mm)
(Lamelarisasi)
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28DEPARTEMEN PA USU 2011
LEBIH PRAKTIS
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DEPARTEMEN PA USU 2011 31
DEPARTEMEN PA FK USU
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33DEPARTEMEN PA USU 2011
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DEPARTEMEN PA USU 2011 34
SLIDE BISA DI LIHAT DI BAWAH MIKROSKOP BERSAMA-SAMA
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Slide Histopatologi
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1. Si-Bajah = FNA
Bahan apusan diapuskan pada gelas objek, dan segera dimasukkan dalam cairan fiksasi alkohol 96% minimal 30 menit. Sesudah 30 menit gelas objek dapat dikeringkan & dikirim ke Sentra Diagnostik Patologi Anatomi.
Dapat juga sediaan apusan dibiarkan kering dalam suhu udara kamar (untuk pewarnaan Giemsa) Lab. PA
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DEPARTEMEN PA USU 2011 37
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2. Bahan cairan
Bahan cairan dapat di kirim segera ke Sentra Diagnostik Patologi Anatomi tanpa fiksasi (sesegera mungkin) atau dimasukkan dalam cairan fiksasi alkohol 50% (vol 1: 1)
Bahan sputum sebaiknya dikirim segera di dalam wadah tertutup tanpa fiksasi
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Papanicollaou
40DEPARTEMEN PA USU 2011
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THANK YOU