Italian Society of Biochemistry and Molecular Biology · SCIENTIFIC COMMITTEE Mauro Magnani -...

Caserta, September 20 – 22, 2017

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SIB 201759th CONGRESSItalian Society of Biochemistryand Molecu lar B io logy

Sponsor

Patrocini

SCIENTIFIC COMMITTEE

Mauro Magnani - Università degli Studi di Urbino “Carlo Bo” - Presidente Società Italiana di Biochimica e Biologia Molecolare

Cesare Balduini - Università degli Studi di Pavia

Luisa Bracci - Università degli Studi di Siena

Paola Bruni - Università degli Studi di Firenze

Rita Casadio - Alma Mater Studiorum - Università di Bologna

Daniele Condorelli - Università degli Studi di Catania

Fulvio Della Ragione - Università degli Studi della Campania “Luigi Vanvitelli”

Luca Federici - Università degli Studi “G. d’Annunzio” Chieti - Pescara

Bruno Giardina - Università Cattolica - Roma

Antonio Lucacchini - Università di Pisa

Francesco Paolo Mancini - Università del Sannio di Benevento

Luigi Palmieri - Università degli Studi di Bari “Aldo Moro”

Paolo Vincenzo Pedone - Università della Campania “Luigi Vanvitelli”

Loredano Pollegioni - Università degli Studi dell’Insubria

Raffaele Porta - Università degli Studi di Napoli “Federico II”

Eugenia Schininà - Università “La Sapienza” di Roma

Alberto Spisni - Università degli Studi di Parma

Renza Vento - Università degli Studi di Palermo

ORGANIZING COMMITTEE

Paolo Vincenzo Pedone - Università degli Studi della Campania “Luigi Vanvitelli” - Presidente del 59° Congresso SIB

Rosario Ammendola - Università degli Studi di Napoli “Federico II”

Angela Arciello - Università degli Studi di Napoli “Federico II”

Ilaria Baglivo - Università degli Studi della Campania “Luigi Vanvitelli”

Maria Luisa Balestrieri - Università degli Studi della Campania “Luigi Vanvitelli”

Giovanna Cacciapuoti - Università degli Studi della Campania “Luigi Vanvitelli”

Angela Chambery - Università degli Studi della Campania “Luigi Vanvitelli”

Antimo Di Maro - Università degli Studi della Campania “Luigi Vanvitelli”

Sabrina Esposito - Università degli Studi della Campania “Luigi Vanvitelli”

Angelo Lupo - Università del Sannio Benevento

Loredana Mariniello - Università degli Studi di Napoli “Federico II”

Mariorosario Masullo - Università degli Studi di Napoli Parthenope

Marina Porcelli - Università degli Studi della Campania “Luigi Vanvitelli”

Mario Felice Tecce - Università degli Studi di Salerno

Si ringrazia il Comandante della Scuola Specialisti della Aeronautica MilitareDomenico Lobuono per la disponibilità accordata ai fini della buona riuscita del Congresso

PROGRAM AT A GLANCEWednesday, September 20

12.00 Opening of the Secretariat and RegistrationAuditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

14.00 Congress Opening and WelcomeAuditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

14.30 “E. Antonini” Lecture“NMR-from Basic Research to Daily Human Life”Kurt Wüthrich, Nobel Prize in Chemistry

Plenary SymposiumProtein Structure, Dynamics and InteractionsAuditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

17.00 Visit to the Caserta Royal Palace and Welcome Cocktail

Thursday, September 21

Plenary Symposium9.00 Signals driving cell proliferation, commitment, and self-renewal

Auditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

11.00 Coffee Break

11.30 Signals driving cell proliferation, commitment, and self-renewalAuditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

12.30 Lunch

Parallel Symposia14.00 Mitochondrial plasticity: from energetic metabolism to ROS signalling

Auditorium-Scuola Specialisti dell’Aeronautica Militare - Viale Ellittico 33, CE

14.00 Enzymes and metabolic pathways: mecha-nisms and technologies foradvancing the frontiers of enzymologyAULA 1 - Univ. degli Studi della Campania “Luigi Vanvitelli” - Polo di Viale Ellittico, 31, CE

15.30 Coffee Break and Poster ExpositionBiblioteca - Univ. degli Studi della Camp. “Luigi Vanvitelli” Polo di Viale Ellittico 31, CE

16.30/ Parallel Sessions: Short talks selected from submitted abstracts18.00 Università degli Studi della Campania “Luigi Vanvitelli” Polo di Viale Ellittico 31, CE

18.30 SIB Members AssemblyMasseria Giò Sole - Capua

20.30 Social DinnerMasseria Giò Sole - Capua

Friday, September 22

Plenary Symposium9.00 Transcriptional regulation, chromatin structure and epigenetic modifications

Auditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

10.30 Coffee Break

Parallel Symposia11.00 Proteomics in Cell Biology and Disease Mechanisms

Auditorium-Scuola Specialisti dell’Aeronautica Militare - Viale Ellittico 33, CE

11.00 Novel Frontiers of Nutritional and Environmental BiochemistryAULA 1 - Univ. degli Studi della Campania “Luigi Vanvitelli” - Polo di Viale Ellittico, 31, CE

13.00 Lunch

Plenary Symposium: Industrial and Molecular BiotechnologiesAuditorium-Scuola Specialisti dell’Aeronautica Militare Viale Ellittico 33, CE

14.30 Session I: Future perspectives in biotechnology research

15.20 Session II: Mechanisms, processes and technologies for innovative applications

16.20 Session III: Molecular targeting for drug discovery

17.00 Closing Remarks

Wednesday, September 20

12.00 Opening of the Secretariat and RegistrationAuditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

14.00 Congress Opening and WelcomeAuditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

14.30 “E. Antonini” LectureChair: Maurizio BrunoriUniversità di Roma “La Sapienza” and Accademia dei Lincei, Roma

Kurt Wüthrich, Nobel Prize in ChemistryThe Scripps Research Institute, La Jolla, CA, USA and ETH Zurich,Switzerland“NMR-from Basic Research to Daily Human Life”

Plenary SymposiumAuditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

Protein Structure, Dynamics and InteractionsChairs: Menico Rizzi

Università del Piemonte Orientale “Amedeo Avogadro”,NovaraAnna MarabottiUniversità di Salerno, Salerno

15.30 Elena ContiMax Planck Institute of Biochemistry, Munich, GermanyThe RNA exosome - ribosome connection: coupling the RNAdegradation and translation machineries

16.00 Carlo CamilloniUniversità di Milano, MilanoMulti-scale dynamics of molecular recognition and assembly

16.20 Barbara CampaniniUniversità di Parma, ParmaCompetition between a toxic tRNAse and the biosyntheticenzyme CysE for binding to O-acetylserine sulfhyrylase

16.40 Beatrice Cobucci-PonzanoIstituto di Bioscienze e Biorisorse, CNR, Napoli3D structure of human lysosomal acid-α-glucosidase providesmolecular bases of pharmacological chaperones interactionsfor the treatment of Pompe disease

16.50 Francesca ValleseUniversità di Padova, PadovaCrystal structure of lpp20 (HP1456) from Helicobacter pylorisuggests it is a human virulence factor

17.00 Visit to the Caserta Royal Palace and Welcome Cocktail



SESSION ISignals driving cell proliferation, commitment, and self-renewalChairs: Rosario Ammendola

Università di Napoli “Federico II”, NapoliAdriana BorrielloUniversità della Campania “Luigi Vanvitelli”, Napoli

9.00 Evzen AmlerCzech Technical University in Prague, Bustehrad, PragueFunctionalized nanofibers for regenerative medicine

9.30 Diego IngrossoUniversità della Campania “Luigi Vanvitelli”, NapoliOne carbon and sulfur amino acid metabolism: two biochemicalpathways connected to new signaling molecules of medicalrelevance

9.50 Daniele Dell’OrcoUniversità di Verona, VeronaPhototransduction in normal and altered conditions: frommolecules to networks

10.10 Paola BruniUniversità di Firenze, FirenzeSphingosine 1-phosphate signaling axis as mediator of vitalskeletal muscle functions

10.30 Marzia PerluigiUniversità di Roma “La Sapienza”, RomaCrosstalk between insulin and mTOR signaling in Alzheimer disease

10.50 Daria M. MontiUniversità di Napoli “Federico II”, NapoliNatural products as a source of antiaging molecules

11.00 Coffee Break

SESSION IISignals driving cell proliferation, commitment, and self-renewalChairs: Michele Caraglia

Università della Campania “Luigi Vanvitelli”, NapoliFederica Maria Angela RizziUniversità di Parma, Parma

11.30 Ferdinando ChiaradonnaUniversità di Milano-Bicocca, MilanoTargeting cell metabolism for cancer therapy: a novel class ofhexosamine Pathway inhibitors with anti-tumor activity in differenttypes of cancer

11.50 Franca EspositoUniversità di Napoli “Federico II”, NapoliImpact of cancer cells metabolic reprogramming on tumorprogression and drug resistance: potential implications for cancertreatment


12.10 Francesca SilvagnoUniversità di Torino, TorinoTGFbeta-induced epithelial-mesenchymal transition: negativefeedback regulation by vitamin D

12.20 Paola GiussaniUniversità degli Studi di Milano, MilanoSphingosine-1-P and its plasma membrane receptors in humanglioma cells

Parallel Symposia

14.00 - 15.30Auditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

Mitochondrial plasticity: from energetic metabolism to ROS signallingChairs: Paolo Sarti - Università di Roma “La Sapienza”, Roma

Giuseppe Fiermonte - Università di Bari “Aldo Moro”, Bari

14.00 Gerald Shadel - Yale School of Medicine, New Haven CT, USAMitochondrial stress signaling in disease, aging and immunity

14.30 Luca Scorrano - Università di Padova, PadovaThe cristae modulator optic atrophy 1 requires mitochondrial ATPsynthase dimerization to safeguard mitochondrial function

14.50 Rino Capitanio - Università di Foggia, FoggiaMitochondria and clock-genes interplay: a dynamic timekeepingof cell metabolism

14.00 - 15.30AULA 1 - Università degli Studi della Campania “Luigi Vanvitelli”Polo di Viale Ellittico, 31, Caserta

Enzymes and metabolic pathways: mecha-nisms and technologies foradvancing the frontiers of enzymologyChairs: Simonetta Bartolucci - Università di Napoli “Federico II”, Napoli

Giovanni Musci - Università del Molise, Campobasso

14.00 Gianfranco Gilardi - Università di Torino, TorinoHuman aromatase: catalytic mechanism and role on the emergingproblem of endocrine disruptors

14.30 Gianluca Molla - Università dell’Insubria, VareseAmino acid oxidases: metabolic complexity from structural simplicity

14.50 Chiara Schiraldi - Università della Campania “Luigi Vanvitelli”, NapoliMetabolic engineering in E. coli K4 towards chondroitin production:an insight in the biochemical machinery of capsular polysaccharidebiosynthesis

12.30 Lunch


15.10 Annamaria Porcelli - Università di Bologna, BolognaUnderstanding the signalling between respiratory Complex I andhypoxia-inducible factor-1α in tumorigenesis

18.30 SIB Members AssemblyMasseria Giò Sole - Capua

15.10 Alessio Peracchi - Università di Parma, ParmaEnzymes that make and enzymes that fix mistakes: Nit1 is a“repair” amidase that hydrolyzes deaminated glutathione

20.30 Social DinnerMasseria Giò Sole - Capua

15.30 - 16.30: Coffee Break and Poster ExpositionBiblioteca - Università degli Studi della Campania “Luigi Vanvitelli” - Polo di Viale Ellittico, 31, Caserta

16.30 - 18.00: Parallel Sessions: Short talks selected from submitted abstractsUniversità degli Studi della Campania “Luigi Vanvitelli” Polo di Viale Ellittico 31, CE

Friday, September 22Plenary SymposiumAuditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

Transcriptional regulation, chromatin structure and epigeneticmodificationsChairs: Giorgio Dieci - Università di Parma, Parma

Michela Grosso - Università di Napoli “Federico II”, Napoli

9.00 Antonio Simeone - IGB - CNR, NapoliTranscription Factors control of Plurypotency

9.30 Diego Pasini - IFOM- IEO, MilanoMechanisms of control of cellular identity by Polycomb chromatinmodifiers

9.50 Italia Di Liegro - Università di Palermo, PalermoRNA as a carrier of epigenetic information

10.05 Paola Costanzo - Università di Napoli “Federico II”, NapoliMultifunctional role of the ZNF224 transcription factor

10.20 Paola Loguercio-Polosa - Universita` di Bari “Aldo Moro”, BariMitochondrial transcription in animal systems: recent advancesand challenges

10.30 Coffee Break


Parallel Symposia

11.00-13.00Auditorium-Scuola Specialisti dell’Aeronautica MilitareViale Ellittico 33, Caserta

Proteomics in Cell Biology and Disease MechanismsChairs: Margherita Ruoppolo - Università di Napoli “Federico II”, Napoli

Andrea Urbani - Università Cattolica Sacro Cuore, Roma

11.00Robert Russell - Heidelberg University, Heidelberg, GermanyCoupling proteomics and genetics to study cilia: a disease relevantorganelle

11.30Vittorio Bellotti - Università di Pavia, PaviaProteolysis and amyloid formation: a new way of reading an old story

11.50Maria Monti - Università di Napoli “Federico II”, NapoliNot all roads lead GAA to lysosomes

12.10Massimo Castagnola - Università Cattolica Sacro Cuore, RomaHuman saliva: a precious bodily fluid rich of information

12.30Angela Chambery - Università della Campania “Luigi Vanvitelli”, CasertaDeciphering the SECRET language of cellular messengers by OMICSapproaches

11.00-13.00AULA 1 - Università degli Studi della Campania “Luigi Vanvitelli”Polo di Viale Ellittico, 31 CasertaNovel Frontiers of Nutritional and Environmental BiochemistryChairs: Cristina Angeloni - Università di Camerino, Camerino

Alberto Zullo - Università del Sannio, Benevento

11.00David Vauzour - University of East Anglia, Norwich, UKNeuroprotective effect of flavonoids and their underlying molecularmechanisms

11.30Luca Tiano - Università Politecnica Marche, AnconaThe use of trout erythrocytes as a model for the study of oxidative stressand damage associated to environmental pollutants exposure

11.50Gian Luigi Russo - Istituto di Scienze dell'Alimentazione, CNR, AvellinoPros and cons of polyphenols in cancer: the example of quercetin inchronic lymphocytic leukemia

12.10Ivana Caputo - Università di Salerno, SalernoContribution of type 2 transglutaminase to the celiac cellular phenotype


12.50Federica Ciregia - Università di Pisa, PisaProteomic approach to study pancreatic human islets after cytokineexposure

12.30Giuseppe Bruschetta - Università di Messina, MessinaEffect of diet on peripheral tryptophanhydroxylase-1 and plasma tryptophan levels in Goldfish

12.45C. Valeria L. Giosafatto - Università di Napoli “Federico II”, NapoliInfluence on food digestion and glycemic index by enzymatic proteincrosslinking


Industrial and Molecular Biotechnologies dedicated to RiccardoCortese and Anna Tramontano

SESSION IFuture perspectives in biotechnology researchChairs: Filiberto Cimino

Università di Napoli “Federico II”, NapoliFrancesco SalvatoreUniversità di Napoli “Federico II” and Ceinge-BiotecnologieAvanzate s.c.ar.l. Napoli

14.30 Gennaro Ciliberto - Istituto Tumori Regina Elena, Roma- Universitàdi Catanzaro, CatanzaroPersonalized medicine in oncology: from target therapies toadvanced molecular diagnostics to genome-based clinical trials

15.00 Roberto Danovaro - President Stazione Zoologica "A. Dohrn", NapoliMarine biotechnology: new opportunities for italian research andindustrial development

SESSION IIMechanisms, processes and technologies for innovative applicationsChairs: Marco Moracci

Università di Napoli “Federico II”, NapoliCarlos Regalado-GonzalesUniversidad Autonoma de Querètaro, Santiago de Querètaro,Mexico

15.20 Marina LottiUniversità di Milano-Bicocca, MilanoCold Biotechnology: enzymes and antifreeze proteins from Antarcticorganisms

15.40 Eugenio Notomista - Università di Napoli “Federico II”, NapoliCryptic antimicrobial peptides, a still unexploited source of bioactivepeptides

13.00 Lunch


16.00 Mohammed Sabbah - An-Najah National University, Nablus, PalestineHydrocolloid materials: reinforcement and new plasticizers

16.10 Riccardo Miggiano - IXTAL srl, NovaraUnderstanding proteins: tailor-made approaches for biotechnologysolutions in industrial processes

SESSION IIIMolecular targeting for drug discoveryChairs: Claudia Martini

Università di Pisa, PisaMarzia BianchiUniversità di Urbino, Urbino

16.20 Loredano Pollegioni - Università dell’Insubria, VareseModulation of NMDA receptor functionality acting on D-serinecatabolism: a novel therapeutic approach for various humanpathologies

16.40 Michele Menotta - Università di Urbino, UrbinoNon-conventional splicing modulation by glucocorticoids: thecase of ATM

16.50 Barbara Cellini - Università di Perugia, PerugiaUse of polymer conjugates for the intraperoxisomal delivery ofengineered human alanine:glyoxylate aminotransferase: a proteintherapy for primary hyperoxaluria type I

17.00 Closing remarks

Thursday, September 21 • POSTER SESSION • 16.30 - 18.00

Aging and Degenerative Diseases - ADD

(Biblioteca - Università degli Studi della Campania “Luigi Vanvitelli” Polo di Viale Ellittico 31, Caserta)

ADD1 - Oxidative modification of proteins in rotenone-induced neurotoxicity in PC12 cells.Elisabetta Chiaradia1*, Andrea Scaloni4, Giovanni Renzone4, Lorena Urbanelli2, Carla Emiliani2, Krizia Sagini2, Angela Gambelunghe3, Mara Caputo1, Sandra Buratta2

1Dept of Veterinary Medicine, University of Perugia, Perugia, Italy;2Dept of Chemistry Biology and Biotechnology, University of Perugia, Perugia, Italy;3Dept of Medicine, University of Perugia, Perugia, Italy;4ISPAAM, National Research Council, Napoli, Italy.

ADD2 - Ergothioneine oxidation protects against high-glucose induced endothelial senescence via SIRT1 and SIRT6.Nunzia d’Onofrio1, Rosario Casale1, Alfonso Giovane1, Luigi Servillo1, Maria Luisa Balestrieri1*

1Department of Biochemistry, Biophysics and General Pathology, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

ADD3 - In vitro evaluation of novel hybrid cooperative complexes (HCC) based on high and low molecular weight hyaluronic acid in wound healing: a steptowards improvement in bioreparationA. D’Agostino, R. Maritato, A. Pirozzi, S. Reale, A. La Gatta, A. Stellavato, L. Corsuto and C. Schiraldi*Department of Experimental medicine. University of Campania “Luigi Vanvitelli” Naples, Italy

ADD4 - A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivoSofia Giorgetti 1, Sara Raimondi 1, P. Patrizia Mangione 1,2, Guglielmo Verona 2, Julien Marcoux 3, Giulia Faravelli 1, Els Pardon 4, Raya Al-Shawi 5, J. Paul Simons 2,Alessandra Corazza 6, Julian D. Gillmore 7, Philip N. Hawkins 7, Maurizia Valli 1, Monica Stoppini 1, Jan Steyaert 4, Gennaro Esposito 8, Vittorio Bellotti *1,2.1Department of Molecular Medicine, Institute of Biochemistry, University of Pavia, Pavia, Italy;2Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London UK;3Department of Chemistry, University of Oxford, Oxford, UK;4Structural Biology Research Centre, VIB , Brussel, Belgium;5Centre for Biomedical Science, Division of Medicine, University College London, London, UK;6Department of Medical and Biological Sciences (DSMB), University of Udine, Udine, Italy;7National Amyloidosis Centre, University College London, London NW3 2PF, UK;8Department of Mathematics, Computer Science and Physics, University of Udine, Udine, Italy

ADD5 - Cyclo (His-Pro) protects SOD1G93A microglial cells from oxidative stressSilvia Grottelli1*, Ilaria Bellezza1, Egidia Costanzi1, Alba Minelli11Department of Experimental Medicine, University of Perugia, Perugia , Italy

ADD6 - The role of clusterin on alpha-synuclein aggregation in an “in vitro” model of Parkinson diseaseChiara Lenzi1,Ileana Ramazzina1, Saverio Bettuzzi1, Federica Rizzi1*

1 Department of Medicine and Surgery, University of Parma, Parma, Italy.


ADD7 - Novel multi-targeted anti-Alzheimer’s ligands from marine sourcesMariorosario Masullo1, Rosa Maria Vitale2, Doriana Desiderio1, Roberta Sgammato1, Vincenzo Rispoli3, Pietro Amodeo2, Rosaria Arcone1

1Department of Movement Sciences and Wellbeing, University of Naples “Parthenope”, Naples, Italy;2Institute of Biomolecular Chemistry, CNR, Pozzuoli (NA), Italy;3Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy.

ADD8 - Potential involvement of D-aspartate metabolism in schizophreniaTommaso Nuzzo1,2, Silvia Sacchi3,4, Francesco Errico1,5, Monica Iannotta6, Carmela Belardo6, Elena Rosini3,4, Zoraide Motta3, Daniela Punzo1,2, Francesco Napolitano1,5,Alessandro Bertolino7, Vito De Novellis6, Sabatino Maione6, Loredano Pollegioni3,4 and Alessandro Usiello*1Laboratory of Behavioral Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy;2Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy;3Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy;4The Protein Factory Research Center, Politecnico di Milano and University of Insubria, Milan, Italy;5Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Naples, Italy;6Department of Experimental Medicine, Section of Pharmacology, The Second University of Naples (SUN);7Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari “Aldo Moro”, Bari, Italy.

ADD9 - Epigenetics in Hyaluronan Synthesis ControlAlberto Passi1, D. Vigetti1, M. Viola1, E. Karousou1, I. Caon1, E. Caravà1, P. Moretto1, G. De Luca1.Department of Medicine and Surgery, University of Insubria, Varese, Italy

ADD10 - The occurrence of a Kv7.4 potassium channel in neuronal mitochondriaGianluca Paventi1*, Gennaro Raimo1, Maria Virginia Soldovieri1, Iolanda Vinciguerra1, Alessandro Medoro1, Salvatore Passarella1, Maurizio Taglialatela2

1Department of Medicine and Health Science “V. Tiberio”, University of Molise, Campobasso, Italy;2Department of Neuroscience, University of Naples, Naples, Italy

ADD11 - The methylation state of D-aspartate oxidase gene predicts D-aspartate concentration in the mammalian brain.Daniela Punzo2,3, Francesco Errico,3,4, Silvia Sacchi5,6, Simona Keller,1,4 Tommaso Nuzzo, Francesco Napolitano, Ermanno Florio,1,4 Ornella Affinito,1,4 Maria Jose` Sisalli4,Loredano Pollegioni,5,6 Lorenzo Chiariotti,1,4 and Alessandro Usiello2,3*

1Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy;2Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Caserta, Italy;3Laboratory of Behavioural Neuroscience, Ceinge Biotecnologie Avanzate, Naples, Italy;4Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;5Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy;6Protein Factory Research Center, Politecnico di Milano and University of Insubria, Milan, Italy.



ADD12 - Unraveling the TZAP interactome by BioID proximity labeling: a step toward the understanding of the telomeres trimming pathwayCamilla Rega1, Rosita Russo1, Julia Su Zhou Li2, Eros Lazzerini Denchi 2*, Angela Chambery1*

1DISTABIF, University of Campania “L. Vanvitelli”, Caserta, Italy;2Department of molecular medicine, The Scripps Research Institute, La Jolla, USA;

ADD13 - Alzheimer’s disease (AD) and Frontotemporal dementia (FTD): investigating the overlap of genetic mutations focusing on CD33 and TREM2.Antonella Rendina1, Sabrina Napoletano1, Graziella Milan2, Laura Fucci3, Emilia Vitale*1

1Institute of Protein Biochemistry (IBP), CNR, Naples, Italy;2Geriatric Clinic “Frullone” ASL Napoli 1, Naples, Italy;3Department of Biology, University of Naples Federico II, Naples, Italy

ADD14 - Impact of Ubiquinol supplementation on endothelial function in subjects with moderate cardiovascular risk: a double blind, randomised, placebo-controlled clinical study.Jacopo Sabbatinelli1, Roberto Antonicelli2, Roberta Galeazzi3, Patrick Orlando4, Laura Mazzanti1, Luca Tiano4*

1 Department of Clinical Sciences., Università Politecnica delle Marche, Ancona, Italy;2 Cardiology Department, National Institute of Hospital and Care for Elderly (INRCA), Ancona, Italy;3 Clinical Laboratory and Molecular Diagnostics, INRCA, Ancona, Italy; 4 Department of Life and Environmental Sciences, Univ. Politecnica delle Marche, Ancona, Italy;

ADD15 - Beneficial Effects of Late-life Enalapril Administration on Heart Mitochondria of Old RatsGiuseppe Sirago1, Anna Picca2, Riccardo Calvani2, Christy S. Carter3, Guglielmina Chimienti1, Angela Maria Serena Lezza1, Vito Pesce1*, Emanuele Marzetti21Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy;2Depart. of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Teaching Hospital “Agostino Gemelli”, Rome, Italy;3Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, USA;

ADD16 - Hyaluronan Hybrid cooperative complexes and linear and crosslinked ha based injectable medical devices differently affect in vitro human adiposestem cell differentiation and proliferationAntonietta Stellavato, Marcella La Noce, Luisana Corsuto, Anna Virginia Adriana Pirozzi, Mario De Rosa, Gianpaolo Papaccio, Virginia Tirino and Chiara SchiraldiDepartment of Experimental Medicine, Section of Biotechnology, Medical Histology and Molecular Biology, Università della Campania Luigi Vanvitelli, Via De Crecchio7, 80138 Naples, Italy

Computational and Systems Biology - CSB

CSB1 - Structure-Based Virtual Screening for the search of novel SMO antagonists: a ligand repurposing approachGiorgio Amendola1, Sandro Cosconati1*

1DiSTABiF, University of Campania Luigi Vanvitelli, Caserta, Italy;



CSB2 - The role of irbesartan in inflammatory processes and oxidative stress triggered by cardiac ischemiaMariarosaria Boccellino, Pasqualina Ambrosio, Giuseppe Bitti, Mario Coppola, Lucio Quagliuolo*Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli" Naples, Italy

CSB3 - BAR 3.0: going beyond protein function annotationGiuseppe Profiti1, Pier Luigi Martelli1, Rita Casadio1

1Biocomputing Group, University of Bologna, Bologna, Italy

CSB4 - N6L interacts with NPM-1 and sensitizes leukemic cells to chemotherapyAntonella De Cola1, Mimma Franceschini1, Roberta Celani1, Emanuela Clemente1, Gianni Colotti2, Adele Di Matteo2, Vincenzo De Laurenzi1, José Courty3, Luca Federici1,*1Ce.S.I MeT. Center of Excellence on Aging and Translational Medicine and Department of Medical, Oral and Biotechnological Sciences, Univ. of Chieti “G. d’Annunzio”;2Institute of Pathology and Molecular Biology, CNR, Roma;3Laboratoire de Recherche sur la Croissance Cellulaire, la Reparation et la Regeneration Tissulaires (CRRET), CNRS, Universite Paris-Est, Creteil;

CSB5 - System biology analysis for dissecting the epithelial mesenchymal transition metabolic programAnna M. Giudetti1*, Eleonora Stanca1, Stefania De Domenico2, Franck Julien3, Isabelle Fournier3, Michel Salzet3, Daniele Vergara1

1DiSTeBA, University of Salento, Lecce, Italy;2Institute of Food Production Sciences, C.N.R. Unit of Lecce, Lecce, Italy;3Laboratoire PRISM - U1192 INSERM, Université de Lille 1, Villeneuve d'Ascq, France;

CSB6 - NMR-based metabolomic investigation of metastatic melanomaVittoria Graziani1,2, Eva Crosas-Molist2, Andrew Atkinson2, Antonio Fiorentino1, Victoria Sanz-Moreno2 and Maria Rosaria Conte2

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania ‘'Luigi Vanvitelli’', via Vivaldi 43, 81100, Caserta,Italy;2Randall Division of Cell and Molecular Biophysics, New Hunt’s House, Guy’s Campus, King’s College London, London SE11UL, UK;

CSB7 - Analysing the relations among genes and polygenic diseases with eDGARGiulia Babbi1, Pier Luigi Martelli1*, Giuseppe Profiti 1, Samuele Bovo1, Castrense Savojardo1, Rita Casadio1

1 Biocomputing Group, University of Bologna, Italy;

CSB8 - Microalgae in circular economy: from waste to high-value productsGanna Petruk1*, Imma Gifuni2, Mariana Roxo3, Paola Imbimbo1, Giuseppe Olivieri2, Antonio Marzocchella2, Renata Piccoli1, Michael Wink3, Daria Maria Monti11Department of Chemical Sciences, University of Napoli “Federico II”, Napoli, Italy;2Department of Chemical Engineering, of Materials and Industrial Production, University of Napoli “Federico II”, Napoli, Italy;3Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany;



CSB9 - Metabolomic approach in the study of inborn errors of metabolismMargherita Ruoppolo1,2*, Rita Pecce 1,2, Guglielmo R.D. Villani1,2, Lucia Albano2, Marianna Caterino1,2, Daniela Crisci2, Maria Grazia Di Girolamo2, Silvia Di Tommaso2,Giovanna Gallo2, Francesco Salvatore2

1Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Naples , Italy;2CEINGE-Biotecnologie Avanzate scarl, Naples, Italy;

CSB10 - Peptidomic profile of in vitro digested bovine, camel, goat and sheep milkDavide Tagliazucchi1*, Serena Martini1, Sherif Shamsia2, Ahmed Helal2, Angela Conte1

1Department of Life Sciences, University of Modena and Reggio Emilia , Reggio Emilia , Italy;2Department of Food and Dairy Sciences and Technology, Damanhour University, Damanhour, Egypt;

CSB11 - A covalent docking approach to simulate the interactions of a novel cephalosporin derivative with their biological targetsAnna Verdino1, Sergio Simone1, Annunziata Soriente1, Margherita De Rosa1, Anna Marabotti1*

1Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano (SA), Italy;

Differentiation and Neoplastic Transformation - DNT

DNT1 - Hippo signaling pathway in human astroglial tumorsM’hammed Aguennouz1,*,Alfredo Conti2, Francesca Polito1, Roberto Arrigo1, Valeria Barresi2 , Alba Migliorato2; Domenico La Torre2, Flavio F. Angileri2, Salvatore Cardali2Antonino Germanò2 ,RM Di Giorgio1.1Department of Experimental and Clinical Medicine, University of Messina, Messina, Italy;2Department of BIOMORF, University of Messina, Messina , Italy;

DNT2 - p57Kip2 phosphorylation modulates its interaction with cyclin-dependent kinasesIlaria Caldarelli, Emanuela Stampone, Maria Speranza, Clementina Barone, Debora Bencivenga, Fulvio Della Ragione and Adriana Borriello*

1Department of Biochemistry, Biophysics and General Pathology; Università della Campania “Luigi Vanvitelli”, Napoli;

DNT3 - Sphingosine 1-Phosphate inside-out signaling is involved in bradykinin-induced myogenic differentiationFrancesca Cencetti1*, Gennaro Bruno2, Caterina Bernacchioni1, Chiara Donati1, Dagmar Meyer zu Heringdorf3, Paola Bruni1.1Dipartimento di Scienze Biomediche Sperimentali e Cliniche “Mario Serio”, Università degli Studi di Firenze, Italia;2Dipartimento di Scienze della Salute, Università degli Studi di Firenze, Italia;3Pharmazentrum Frankfurt/ZAFES, Goethe University Hospital, Frankfurt/Main, Germany;

DNT4 - Exogenous fatty acids modulate ER composition and lipid metabolism in breast cancer cellsCorsetto PA*, Montorfano G, Zava S, Colombo I, Rizzo AMDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy;



DNT5 - Investigation of Lipid Metabolism in Mucopolysaccharidosis type IIIB mouse modelMichele Costanzo1,2, Marianna Caterino1,2,3, Valeria De Pasquale1, Luigi Michele Pavone1, Margherita Ruoppolo1,2,3*

1Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;2Associazione Culturale DiSciMuS RFC 80026, Casoria, Naples, Italy;3CEINGE - Biotecnologie Avanzate scarl, Naples, Italy;

DNT6 - Development of a Novel Therapeutic Approach for Mucopolysaccharidosis DiseasesValeria De Pasquale1, Patrizia Sarogni1, Simona Paladino1, Luigi Michele Pavone1*

1Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;

DNT7 - Standardization of an experimental system of adherent primary mesenchymal colon cancer cells and paired tumorspheres for the study of cancer cellmigration, stemness features and drug response.Marina De Rosa1, Valeria Costabile1, Angelita Poziello1, Mimmo Turano2, Francesca Duraturo1, Paolo Delrio3, Daniela Rega3, Ugo Pace3, ConcettaDodaro4, Marco Milone4 and Paola Izzo1,*

1Department of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate, University of Naples “Federico II”, Naples, Italy;2Department of Biology, University of Naples FedericoII, Naples, Italy;3Colorectal Surgical Oncology, Istituto Nazionale per lo studio e la cura dei tumori, “Fondazione Giovanni Pascale” IRCCS-Naples, Italy;4Advanced Biomedical Sciences Department, University of Naples "Federico II", AOU "Federico II", Naples, Italy;

DNT8 - MSH2 3’UTR as putative binding site of MIR-137Francesca Duraturo1, Raffaella Liccardo1, Marina De Rosa1, Paola Izzo1,*

1Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Naples , Italy;

DNT9 - Nicotinamide N-methyltransferase: a new potential biomarker for cutaneous malignant melanomaGiulia Ganzetti1, Davide Sartini2, Anna Campanati1, Elisa Molinelli1, Valerio Brisigotti1, Monia Cecati2, Valentina Pozzi3, Roberto Campagna2, Stefania Fumarola2,Corrado Rubini4, Annamaria Offidani1, Monica Emanuelli2,3*.1Department of Clinical and Molecular Sciences,2Department of Clinical Sciences,3New York-Marche Structural Biology Centre (NY-MaSBiC),4Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.

DNT10 - GATA-1 isoforms differently contribute to the production and compartmentation of reactive oxygen species in myeloid cellsRaffaele Sessa, Maria Grazia Miranda, Silvia Trombetti, Rosa Catapano, Margherita Santoro, Maria Pia Ottaiano, Patrizia Riccio, Paola Izzo, Michela Grosso*Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy



DNT11 - Identification of a retinoid-responsive element in the GATA-1 promoter and its role in the promyelocytic differentiation induced by all-trans retinoicacid(ATRA)Raffaele Sessa, Rita Ruggiero, Maria Pia Ottaiano, Silvia Trombetti, Margherita Santoro, Maria Grazia Miranda, Rosa Catapano, Paola Izzo, Michela Grosso*Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;

DNT12 - Effect of hypoxia on H2S metabolism in colon cancer cellsFrancesca Malagrinò1,2, Karim Zuhra1,2, Daniela Mastronicola1,2, Ludovica Mascolo1, João B. Vicente3, Elena Forte1 and Alessandro Giuffrè2*

1Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy;2CNR Institute of Molecular Biology and Pathology, Rome, Italy;3Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal;

DNT13 - Downregulation of microRNA-125a in Hepatocellular Carcinoma and Overexpression of its Targets Sirtuin-7, Matrix Metalloproteinase-11, and c-RafMarta Panella1, Nicola Coppola2, Giorgio de Stefano3, Silvia Zappavigna4, Lorenzo Onorato2, Nunzia Farella3, Nicola Mosca1, Nicoletta Potenza1, Paola Stiuso4,Elena Amendola5, Carmine Minichini2, Mario Starace2, Michele Caraglia4, Aniello Russo1*1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Caserta, Italy;2Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy;3IX Interventional Ultrasound Unit for Infectious Diseases, AORN dei Colli, P.O. Cotugno, Naples, Italy;4Department of Biochemistry, Biophysics and General Pathology, University of Campania Luigi Vanvitelli, Naples, Italy;5Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;

DNT14 - Looking for novel antitumor compounds from Fabaceae speciesBrigida D’Abrosca1, Nicoletta Potenza1, Vittoria Graziani1, Monica Scognamiglio1, Assunta Esposito1, Aniello Russo1, Fortunato Ciardiello2, Teresa Troiani2,Antonio Fiorentino*

1Dip. di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche (DiSTABiF), Università degli Studi della Campania “Luigi Vanvitelli”, via Vivaldi 43 I-81100, Caserta,Italy;2 Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale "F. Magrassi - A. Lanzara", Università degli Studi della Campania “Luigi Vanvitelli”- I-80131,Via Pansini, 5 - Napoli, Italy;

DNT15 - Activation of the hypoxia-inducible factor 1£\ promotes myogenesis through the non-canonical WNT pathway leading to hypertrophic myotubesGiulia Resmini1,2, Federica Cirillo1, Andrea Ghiroldi1, Marco Piccoli1, Sonia Bergante1, and Luigi Anastasia1,2

1IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy;2Department of Biomedical Sciences for Health, University of Milan, Milan, Italy;

DNT16 - FR051, a novel Hexosamine Biosynthetic Pathway inhibitor, induces cell death in primary and metastatic pancreatic cancer modelsFrancesca Ricciardiello1*, Giuseppina Votta1, Roberta Palorini1, Francesca Tinelli1, Antonio Castagna1, Humberto DeVitto1,2, Barbara La Ferla1, Ferdinando Chiaradonna1

1Department of Biotechnology and Biosciences, University of Milano “Bicocca”, Milano , Italy;2Hormel Institute, University of Minnesota, United States of America.



DNT17 - Production of spheroids from human primary skin myofibroblasts: an experimental model to study myofibroblast deactivationMaria Rosaria Ruocco1, Rosarita Nasso1,2, Emmanuele De Vendittis1, Mariorosario Masullo1,2, Martina Simonetti1, Angelica Avagliano3, Giuseppina Granato3,Stefania Masone4, Stefania Montagnani3, Alessandro Arcucci3*

1Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy;2Department of Movement Sciences and Wellbeing, University of Naples “Parthenope”, Naples, Italy;3Department of Public Health, University of Naples Federico II, Naples, Italy;4Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy;

DNT18 - uL3 is a key regulator of oxidative stress response genes in multidrug resistant lung cancer cellsAnnapina Russo1, Assunta Saide1, Silvia Smaldone2, Raffaella Faraonio3 and Giulia Russo1

1Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy;2Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;3Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Via Sergio Pansini 5, 80131 Naples, Italy;

DNT19 - The Lysophosphatidic Acid Acyltransferase (LPAATs) Enzymes and their Role in Membrane Transport Alterations in CancerStefania Serpico, Angela Filograna, Daniela Corda, Alberto Luini, Carmen Valente*Institute of Protein Biochemistry, National Research Council, Naples, Italy;

DNT20 - Human acetyl-CoA carboxylase 1 mRNA translation is enhanced in HepG2 cells under endoplasmic reticulum stress, serum deprivation or hypoxiaMariangela Testini1*, Stefano Tacconi1, Gabriele V. Gnoni1, Luisa Sicuella1, Fabrizio Damiano1

1 Laboratory of Biochemistry and Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Prov. le Lecce-Monteroni, Lecce 73100, Italy;

DNT21- Cladosporols A and B from Cladosporium Tenuissimum act as PPARy ligands and inhibit adipogenesis in 3T3L1 cellsPamela Ziccardi,1 Cioffi Valentina,1 Sabrina Dallavalle,2 Salvatore Moricca,3 Vittorio Colantuoni,1 Angelo Lupo1*

1Dipartimento di Scienze e Tecnologie, Università del Sannio, via Port’Arsa 11, 82100 Benevento, Italy;2Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, via Celoria 2, 20133 Milano, Italy;3Dipartimento di Scienze delle Produzioni Agroalimentari e dell'Ambiente (DiSPAA), Università degli Studi di Firenze, Piazzale delle Cascine 18, 50144 Firenze, Italy.

Membranes - M

M1 - Fad synthase (fads) localization and function in neuronal cell models: a possible involvement of fads in the pathogenesis of neurodegenerative diseasesGraziana Difonzo, Piero Leone, Maria Tolomeo, Marianna Loredana Defrancesco, Maria Teresa Damiano, Teresa Anna Giancaspero, Matilde Colella, Maria Barile*

Department of Biosciences, Biotechnology and Biopharmaceutics, via Orabona 4, Bari 70126, Italy;



M2 - Membrane transporters as target of xenobioticsCesare Indiveri1,2, Mariafrancesca Scalise1, Michele Galluccio1, Lorena Pochini11Department DiBEST, University of Calabria, Arcavacata di Rende, Italy2CNR Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, Bari, Italy

M3 - Is the Pseudoxanthoma Elasticum (PXE) a purinergic disease?Fabio Martinelli, Maria Carmela Pace, Angela Ostuni, Maria Francesca Armentano, Rocchina Miglionico and Faustino BisacciaDepartment of Sciences, University of Basilicata, Potenza, Italy;

M4 - Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cellsSimona Daniele1, Deborah Pietrobono1, Barbara Costa1, Mariateresa Giustiniano2, Valeria La Pietra2, Chiara Giacomelli1, Giuseppe La Regina3, Romano Silvestri3,Sabrina Taliani1, Maria Letizia Trincavelli1, Federico Da Settimo1, Ettore Novellino2, Luciana Marinelli2, Claudia Martini1*1Department of Pharmacy, University of Pisa, Pisa, Italy;2Department of Pharmacy, University of Naples Federico II, Italy;3Istituto Pasteur Italia-Fondazione Cenci Bolognetti, University of Rome, Italy;

M5 - Mechanisms of CtBP-1/BARS-mediated mitotic Golgi fragmentationMichela Napolitano, Stefano De Tito, Angela Filograna, Alberto Luini, Daniela Corda, Anna Chiara De Luca and Carmen ValenteInstitute of Protein Biochemistry, National Research Council, Naples, Italy;

M6 - Mitochondrial ATP-Mg/phosphate carriers transport divalent inorganic cations in complex with ATPMagnus Monné1,2, Lucia Daddabbo1, Lorena Carla Giannossa3, Maria Cristina Nicolardi1, Luigi Palmieri1,4, Daniela Valeria Miniero1, Annarosa Mangone3,

Ferdinando Palmieri1,4 *

1Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Via E. Orabona 4, 70125 Bari, Italy;2Department of Sciences, University of Basilicata, Via Ateneo Lucano 10, 85100 Potenza, Italy;3Department of Chemistry, University of Bari, Via E. Orabona 4, 70126 Bari, Italy;4Institute of Biomembranes, Bioenergetics and Biotechnology, Consiglio Nazionale delle Ricerche, 70126 Bari, Italy;

M7 - Palmitate lipotoxicity in enteric glial cellsMaya Petricciuolo1, Magdalena Davidescu1, Leonardo Gatticchi1, Lanfranco Corazzi1, Angela Corcelli2, Rita Vitale2, Lara Macchioni1*

1Department of Experimental Medicine, University of Perugia, Perugia, Italy;2 Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “A. Moro”, Bari, Italy.

M8 - Mitochondrial cAMP prevents apoptosis of cardiac myoblast cells modulating Sirt3 protein level and OPA1 processingAnna Signorile1*, Arcangela Santeramo1, Grazia Tamma2, Tommaso Pellegrino2, Susanna D’Oria3, Paolo Lattanzio4, Domenico De Rasmo 4.1 4 Dept. of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro";2 Dept. of Bioscience, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro";3 Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”,4Institute of Biomembrane, Bioenergetics and Molecular Biotechnology, CNR, Bari



Nutrition and Environment - NE

NE1 - Neuroprotective effect of different virgin olive oil extracts in SH-SY5Y cells.Cristina Angeloni1, Maria Cristina Barbalace2, Laura Giusti3, Maria Digiacomo3,Clementina Manera3, Antonio Lucacchini3, Silvana Hrelia2*

1School of Pharmacy., University of Camerino , Camerino , Italy;2Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Rimini, Italy;3Department of Pharmacy, University of Pisa, Pisa Italy;

NE2 - Synthetic and Natural Avenanthramides from Oat: Antioxidant, Anti-proliferative and Anti-inflammatory ActivitiesElena Antonini, Emanuele Salvatore Scarpa, Michele Mari, Paolino Ninfali*Department of Biomolecular Sciences, University of Urbino, Urbino, Italy

NE3 - Glycoxidative stress and Paraoxonase-2 in intestinal cells: effect of apple polyphenolsTiziana Bacchetti1*, Camilla Morresi1, Imma Turco2, Gianna Ferretti 2, Davide Sartini2, Stefania Fumarola2, Monica Emanuelli21Department of Life and Environmental Sciences (DISVA),2Department of Clinical Sciences (DISCO), Polytechnic University of Marche, Ancona, Italy

NE4 - The uncommon redox mechanism of ergothioneineMaria Luisa Balestrieri1, Luigi Servillo1, Rosario Casale1, Alfonso Giovane1, Domenico Castaldo2, Domenico Cautela2, Nunzia D’Onofrio1*

1Department of Biochemistry, Biophysics and General Pathology, Università degli Studi della Campania "Luigi Vanvitelli," Naples, Italy;2Stazione Sperimentale per le Industrie delle Essenze e dei Derivati dagli Agrumi, Azienda Speciale della Camera di Commercio di Reggio Calabria, 12-89125,Reggio Calabria, Italy;

NE5 - Quercetin supplementation decreases erythrocytes oxidative damage at resting and after an acute bout of eccentric exercise in humansRoberta Ceci1*, Guglielmo Duranti1, Federica Patrizio3, Ilenia Bazzucchi3, Paolo Sgrò2, Luigi Di Luigi2, Stefania Sabatini1, Francesco Felici31 Laboratory of Biochemistry of Movement,2 Unit of Endocrinology and3 Laboratory of Exercise Physiology, Università degli Studi di Roma “Foro Italico”, Department of Movement, Human and Health Sciences, Rome, Italy

NE6 - Valorization of olive mill wastewaters by membrane processes to recovery natural antioxidant compounds for cosmeceutical and nutraceutical applicationsLuisana Corsuto1, Alberto Alfano1, Rosario Finamore1, Simona Barbuto Ferraiuolo1, Chiara Schiraldi1*

1Department of Experimental Medicine, Section of Biotechnology and Molecular Biology, University of Campania L. Vanvitelli, Naples, Italy



NE7 - Phytochemical profile, antioxidant and anti-ageing properties of Citrus bergamia juicesa

Eleonora Da Pozzo1, Marinella De Leo1, Chiara Sinisgalli2, Luigi Milella2, Chiara Cavallini1, Vincenzo Calderone1, Luisa Pistelli1, Alessandra Braca1, Claudia Martini1*

1Department of Pharmacy, University of Pisa, Pisa, Italy; 2Department of Science, University of Basilicata, Potenza, Italy

NE8 - Relevance of oleic acid and hydroxytyrosol, main compounds of extravirgin olive oil, in the inhibition of cholesterol and fatty acid biosyntheses in C6glioma cellsFabrizio Damiano1*, Paola Priore2, Mariangela Testini1, Stefano Tacconi1, Antonio Gnoni3, Luisa Siculella 11 Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce , Italy;2 CNR-NANOTEC, Lecce, Italy;3Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari “Aldo Moro”, Bari, Italy;

NE9 - Vegetable waste biomass as a renewable source of value-added polyphenols and polysaccharidesPaola Di Donato1,2*, Annarita Poli2, Giuseppina Tommonaro2, Gabriella Santagata3, Barbara Nicolaus2

1Department of Science and Technology, Parthenope University, Naples, Italy;2Institute of Biomolecular Chemistry; National Council of Research, Pozzuoli, Naples, Italy;3 Institute for Polymers, Composites and Biomaterials National Council of Research, Pozzuoli, Naples, Italy;

NE10 - Natural antioxidants to improve cell culture conditions of amniotic fluid stem cells.Pasquale Marrazzo1, Michela Freschi1, Cristina Angeloni2, Cecilia Prata3, Tullia Maraldi4, Silvana Hrelia1*

1Department for Life Quality Studies University of Bologna;2School of Pharmacy., University of Camerino;3Department of Pharmacy and Biotechnology University of Bologna;4Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia;

NE11 - Nutritional values and chemical composition of Eurasian woodcock (Scolopax rusticola L.) meatNicola Landi1, Sara Ragucci1, Michelina Fiorentino1, Antimo Di Maro1*

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania ‘'Luigi Vanvitelli’', Caserta, Italy;

NE12 - A new antioxidant system for the human intestinal mucosa: the archaeal peroxiredoxin Bcp1 adsorbed to spore of Bacillus megateriumDanila Limauro1*, Francesca Anna Fusco, Maria Michela Lanzilli1, Giuliana Donadio1, Simonetta Bartolucci1, Rachele Isticato1*

1Department of Biology, University of Naples Federico II, Naples, Italy.

NE13 - 17β-estradiol mediated potentiation of sulforaphane effects on cardiac cellsMaria Cristina Barbalace1, Cristina Angeloni2, Marco Malaguti1, Yury Ladilov3, Vera Regitz-Zagrosek3, Silvana Hrelia1

1Department for Life Quality Studies, University of Bologna;2School of Pharmacy, University of Camerino;



NE14 - Hydrocolloid-based coatings to prevent acrylamide formation in fried foodsAsmaa Al-Asmar1,2, Daniele Naviglio1, C. Valeria L. Giosafatto1 and Loredana Mariniello1*

1Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy;2Analysis, Poison control and Calibration Center, An-Najah National University, Nablus, Palestine;

NE15 - Expression of mitochondrial pyruvate carrier in different metabolic conditions in HepG2 and HEK 293 cellsAgata Petillo, Flavia Cuviello, Sabino Bufo, Faustino Bisaccia, Angela Ostuni*Department of Sciences, University of Basilicata, Potenza , Italy

NE16 - Bioactive peptides from buffalo milkFederica Pinto1, Alfonso Giovane1, Luigi Servillo1, Maria Luisa Balestrieri1*;1Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Naples, Italy

NE17 - Development of new nutraceutical formulations and their evaluation on in vitro simplified steatosis model.Anna Virginia Adriana Pirozzi1, Antonietta Stellavato1, Francesca de Novellis1, Ilaria Scognamiglio1, Valentina Vassallo1, Mario De Rosa1, Chiara Schiraldi1*1Department of Experimental Medicine, University of Campania Luigi Vanvitelli, Naples , Italy;

NE18 - Effect of sulfuraphane on aquaporin-8 in a leukemic cell lineCecilia Prata1, Emanuela Leoncini2, Monia Lenzi1, Tullia Maraldi3, Laura Zambonin1, Cristina Angeloni4, Silvana Hrelia2, Diana Fiorentini11 Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy;2Department for Life Quality Studies, University of Bologna, Rimini, Italy;3 Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy;4School of Pharmacy, University of Camerino, Camerino, Italy

NE19 - Spermidine, a New Cationic Plasticizer for Polysaccharide- and Protein-Based FilmsMohammed Sabbah1,2, Prospero Di Pierro1, Marilena Esposito1, Carlos Regalado Gonzales3, and Raffaele Porta1*

1Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy,2Department of Nutrition and Food Technology, An-Najah National University, Nablus, Palestine,3Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, UniversidadAutónoma de Querétaro, C.U., Cerro de la Campana s/n Querétaro, Mexico

NE20 - Endocrine distruptors: bisphenols citotoxicity and effects on cellular iron homeostasisAntonella Capuozzo, Marialuisa Piccolo, Giacomo Russo, Lucia Grumetto, Francesco Barbato, Carlo Irace and Rita Santamaria*Department of Pharmacy, School of Medicine and Surgery, University of Naples “Federico II”, Naples, Italy;



NE21 - Synthesis of 5-S-lipoylhydroxytyrosol with enhanced ability in protecting human erythrocytes from mercury toxicity compared with its precursor, thenatural phenol hydroxytyrosolFabiana Tortora1, Lucia Panzella2, Arbace Officioso1, Maria Laura Alfieri2, Alessandra Napolitano2, Caterina Manna1*

1Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Naples, Italy;2Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy;

NE22 - Modulation of Cytokine Release from Human Gingival Mesenchymal Stem Cells: Effects of Ribes Nigrum Bud ExtractM. Letizia Trincavelli1,3*, Chiara Giacomelli1, Letizia Natali1, Marinella De Leo1, Simona Daniele1, Marco Nisi2, Filippo Graziani2,3, Alessandra Braca1,3, Claudia Martini1,3

1Department of Pharmacy, University of Pisa, Pisa, Italy;2Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy;3Centro Interdipartimentale di Ricerca "Nutraceutica e Alimentazione per la Salute", University of Pisa, Pisa, Italy;

NE23 - Taste receptor polymorphisms: the hidden side of obesityArianna Vignini1, Monia Cecati1, Sofia Pugnaloni1, Francesca Borroni2, Jacopo Sabbatinelli1, Marina Taus2, Eleonora Salvolini1, Monica Emanuelli1, Laura Mazzanti11Department of Clinical Sciences, Università Politecnica Delle Marche, Ancona, Italy;2Dietetica e Nutrizione Clinica, Ospedali Riuniti di Ancona, Italy;

Proteins - P

P1 - Physicochemical, Mechanical and Antimicrobial Properties of an Edible Coating Based on Chitosan and Pea Protein Crosslinked with TransglutaminaseBlanca García Almendárez1, Prospero Di Pierro2, Carlos Regalado González1, Monserrat Escamilla García 1, Astrid Saraí García Tarabay1*

1Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de la Campana s/n Querétaro, Mexico;2Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy;

P2 - An Epitope Grafting Approach to Meioidosis Vaccine Component DesignGourlay L.J.1, Amabili M.1, Matterazzo E. 1, Tarantino D. 1, Peri C. 2, Gori A. 2, Capelli R. 2, Colombo G. 2 and Bolognesi M. 1 1Dipartimento di Bioscienze, Università di Milano, 20133, Milano, Italy 2Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Via Mario Bianco, 9, 20131, Milano, Italy

P3 - Members of the GADD45 protein family form toxic amyloid-like aggregates under physiological conditionsDaniela Caruso1,2, Giovanni Smaldone3,Annalia Focà1,Alessia Ruggiero1, Annamaria Sandomenico1, Menotti Ruvo1, Luigi Vitagliano1*

1Institute of Biostructures and Bioimaging, Italian Research National Council, Naples, Italy;2Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy;3IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy;



P4 - The archaeal lysogeny regulator F55: from discovery to in vitro and in vivo characterizationsSalvatore Fusco1,2, Martina Aulitto1, Qunxin She2, Simonetta Bartolucci1, Patrizia Contursi1*

1Dipartimento di Biologia, Università degli Studi di Napoli Federico II, Napoli, Italy;2Danish Archaea Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark;

P5 - The effect of CBX7/PRMT1 interaction on E-cadherin expressionCozzolino F.1, Federico A.2, Fusco A.2, Pucci P.1 and Monti M.11Department of Chemical Sciences, University “'Federico II” of Naples and CEINGE Biotecnologie Avanzate, Italy;2Ist. di Endocrinologia ed Oncologia Sperimentale - CNR c/o Dip. di Medicina Molecolare e Biotecnologie Mediche, Univ. degli Studi di Napoli “Federico II”, Naples, Italy

P6 - The prokaryotic zinc finger domains: folding mechanisms and amyloid fibrils formation propensityGianluca D’Abrosca1*, Maddalena Palmieri1, Luigi Russo1, Valeria Sivo1, Mario De Stefano1, Danilo Milardi2, Paolo Vincenzo Pedone1, Carla Isernia1, Gaetano Malgieri1,

Roberto Fattorusso1

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Via Vivaldi 43, 81100 Caserta (Italy);2Institute of Biostructures and Bioimaging-CNR, Viale A. Doria 6, 95125 Catania (Italy);

P7 - Transglutaminase-Crosslinked Protein Films Reinforced by Mesoporous Silica NanoparticlesProspero Di Pierro1 , Inigo Fernandez1*, Carlos Regalado-Gonzales2, Blanca E. Garcia-Almendarez2, and Raffaele Porta1

1Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy;2Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de la Campana s/n Querétaro, Mexico

P8 - Isolation of a novel ribosome-inactivating protein from seeds of Araujia sericifera Brot.Sara Ragucci1, Federica Di Costanzo1, Raffaella Piccirillo1, Nicola Landi1 Antimo Di Maro1

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, Caserta, Italy;

P9 - Quinoa Protein/Chitosan Films Crosslinked with TransglutaminaseMarilena Esposito1, Prospero Di Pierro1, Blanca Estela García Almendárez2 Carlos Regalado González2, Astrid Saraí García Tarabay2, Monserrat Escamilla García2

1Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy;2Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de la Campana s/n Querétaro, México

P10 - Butyrylcholinesterase Inhibitors: Structure-Activity Relationships of 2-Phenylbenzofuran derivativesAntonella Fais1*, Giovanna L. Delogu 1, Benedetta Era 1, Amalia Di Petrillo1, Amit Kumar2,3, Paola Caria4, Sonia Floris1, Francesca Pintus1

1Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy;2Department of Mech., Chem. and Material Engineering, University of Cagliari , Cagliari, Italy;3Biosciences Sector, CRS4 ,Pula , Italy;4Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy;



P11 - Investigations on onconase dimerizationSabrina Fasoli*, Andrea Fagagnini, Marcello Smania, Elena Butturini, Giovanni GotteSection of Biological Chemistry of the Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy;

P12 - Identification and characterization of toxin-antitoxin systems in Lactobacillus speciesAlberto Ferrari1,2, Yabre Korotoum2, Stefano Maggi3, Camilla Lazzi2, Barbara Montanini3, Claudia Folli2*

1 Interdepartment Center SITEIA.PARMA, University of Parma, Parma, Italy;2Department of Food and Drug, University of Parma , Parma , Italy;3Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma , Italy;

P13 - TtSmtB, an arsenic sensing transcriptional repressor, mediates cadmium resistance in Thermus thermophilus HB27Immacolata Antonucci1, Giovanni Gallo1, Josè Berenguer2, Simonetta Bartolucci 1, Gabriella Fiorentino1*

1Dipartimento di Biologia, Università degli Studi di Napoli Federico II, Complesso Universitario Monte S. Angelo, Naples, Italy;2Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Campus Universidad Autónoma de Madrid, 28049, Madrid, Spain;

P14 - Preparation and characterization of grass pea-based bioplastics prepared in the presence of transglutaminaseC. Valeria L. Giosafatto1*, Valentina Roviello1, Asmaa Al-Asmar1,2, Carlos Regalado-Gonzales3, Antonio D’Angelo1, Loredana Mariniello1

1Department of Chemical Sciences, University of Naples “Federico II”, Naples, Italy,2Analysis, Poison control and Calibration Center, An-Najah National University, Nablus, Palestine,3Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, C.U., Cerro de la Campana s/n Querétaro, Mexico

P15 - Carbohydrate Active Enzymes from hyperthermophilic microbial consortia for the plant biomass degradation: a metagenomic approach.Roberta Iacono1, Andrea Strazzulli1, Beatrice Cobucci-Ponzano1, Rosa Giglio1, Luisa Maurelli1, Federico M. Lauro2, Bernard Henrissat3 and Marco Moracci*1-4.1Institute of Biosciences and BioResources, Consiglio Nazionale delle Ricerche UOS Napoli, Via P. Castellino 111, 80131, Naples, Italy,2School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, NSW, 2052, Australia,3Architecture et Fonction des Macromolécules Biologiques, UMR 7257 - CNRS & Aix-Marseille Université, 163 Avenue de Luminy, 13288 Marseille, France,4 Department of Biology, University of Naples "Federico II", Complesso Universitario di Monte S. Angelo, Via Cupa Nuova Cinthia 21, 80126 Napoli, Italy;

P16 - Identification of Molecules Capable of Modulating the Activity of Enzymes Involved in the Extracellular Matrix RemodelingAndrea Ianni1, Giuseppe Celenza and Nicola Franceschini11Department of Biotechnological and Applied Clinical Sciences, University of L’'Aquila, L’Aquila, Italy;



P17 - Molecular basis of Sorcin function in calcium homeostasis and multidrug resistance in tumors.Ilaria Genovese1, Annarita Fiorillo1, Silvia Masciarelli3, Francesco Fazi3, Gianni Colotti2 Andrea Ilari21Department of Biochemical Sciences, Sapienza University, Rome, Italy;2 IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy,3 Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University, Rome, Italy;

P18 - Functional and structural comparison of human phosphomannomutasesLiguori L.1,3, Monticelli M.1,2, Cimmaruta C.1,2, Citro V.2, Cubellis M.V.2, Andreotti G.11Institute of Biomolecular Chemistry - CNR, Pozzuoli-Naples, Italy;2Department of Biology, University of Naples Federico II, Italy;3Department of Environmental, Biological, and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Italy;

P19 - Allosteric behaviour of the main endocannabinoid-degrading enzyme FAAHMauro Maccarrone1,2, Monica Simonetti3, Annalaura Sabatucci3, Clotilde B. Angelucci4, Alice Ballone5, Sergio Oddi2,4, Beatrice Dufrusine3, Gianni De Fabritiis5,Enrico Dainese2,3

1Department of Medicine, Campus Bio-Medico University of Rome, Rome, Italy;2European Center for Brain Research (CERC)/Santa Lucia Foundation, Rome, Italy;3Faculty of Biosciences, and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy;4Faculty of Veterinary Medicine, University of Teramo, Italy; 5Barcelona Biomedical Research Park (PRBB), University of Pompeu Fabra, Barcelona, Spain;

P20 - Functional characterization of L-cystathionine £^-lyase from Toxoplasma gondii.Elena Maresi, Silvia Fruncillo, Paola Dominici, Alessandra Astegno*Department of Biotechnology, University of Verona, Verona, Italy;

P21 - Crystallization of Euphorbia characias Latex PeroxidaseRosaria Medda1*, Dario Piano1, Sonia Floris1 Cristiano De Sousa Mota2, Davide De Sanctis2, Francesca Pintus1

1Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy; 2ESRF - The European Synchrotron, Grenoble, France;

P22 - RHA-P: a novel bacterial α-L-rhamnosidase of biotechnological relevance from Novosphingobium sp. PP1YFrancesca Mensitieri1, Federica De Lise1, Valeria Cafaro1, Maria Lumacone1, Andrea Strazzulli1, Eugenio Notomista1, Marco Moracci1, Alberto Di Donato1, Viviana Izzo2*

1Department of Biology, University of Naples Federico II, Naples, Italy; 2Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy;



P23 - Dependence of Oxidative Stress on the Oxygen Binding Properties of PEGylated Hemoglobin-Based Oxygen Carriers in Transfused Guinea PigsEsra'a Ali Mohammad Alomari1, Stefano Bruno1, Luca Ronda2, Gianluca Paredi1, Riccardo Piano1, Stefano Bettati2, Davide Olivari3, Francesca Fumagalli3, Deborah Novelli3,Giuseppe Ristagno3, Roberto Latini3, Chris Cooper4, Reeder Brandon4, Andrea Mozzarelli1*

1Department of Food and Drug, University of Parma, Parma, Italy;2Department of Medicine and Surgery, University of Parma, Parma , Italy;3Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy;4School of Biological Sciences, University of Essex, Colchester, United Kingdom;

P24 - Proteomic analysis of bone marrow derived human MSC secretome stimulated with pro-inflammatory cytokinesNonnis Simona1, Elisa Maffioli 1*, Fabiana Santagata 1, Francesca Grassi Scalvini 1, Morelli Silvia 2, Armando Negri 1,2, Antonella Viola 3 ,Gabriella Tedeschi 1,2

1 Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Milano, Italy;2 Fondazione Filarete, Milano, Italy; 3 Dipartimento di Scienze Biomediche, Università di Padova, Padova, Italy;

P25 - Comparative characterization of yeast and human 3-ketosteroid reductase, two moonlighting proteins that share a jobSalvatore Adinolfi1, Gianni Balliano1, Giulia Pavan1, Terenzio Ferrante1, D. Poirier2, Simonetta Oliaro-Bosso1*

1Department of Scienza e Tecnologia del Farmaco, University of Torino, Via Giuria 9, 10125 Torino, Italy;2 Department of Molecular Medicine, Université Laval, Québec, Canada;

P26 - Differentially expressed muscle proteins are associated with healthy longevity effects of lifelong football trainingEsther Imperlini1, Annalisa Mandola2, Annamaria Mancini2,3, Daniela Vitucci1, Morten Bredsgaard Randers4,5, Peter Krustrup5,6, Francesco Salvatore3, Pasqualina Buono1,2,3,Stefania Orrù1,2,3*

1SDN IRCCS, Napoli, Italy;2Dipartimento di Scienze Motorie e del Benessere, Universita` ‘'Parthenope’' di Napoli, Napoli, Italy;3CEINGE Biotecnologie Avanzate, Napoli, Italy;4Copenhagen Centre for Team Sport and Health, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark;5Department of Sports Science and Clinical Biomechanics, SDU Sport and Health Sciences Cluster (SHSC), Faculty of Health Sciences, University of Southern Denmark,Odense, Denmark;6Health Sciences, College of Life and Environmental Sciences, St. Luke’s Campus, University of Exeter, Exeter, UK

P27 - A strategy to find a cell surface receptor for the alpha-gliadin peptide 31-43Gaetana Paolella1*, Marilena Lepretti1, Stefania Martucciello1, Nanayakkara Merlin2,3, Maria Vittoria Barone2,3, Carla esposito1,2, Ivana Caputo1,2

1Department of Chemistry and Biology, University of Salerno, Fisciano (SA) , Italy;2ELFID (European Laboratory on Food-Induced Diseases), University of Salerno , Fisciano (SA), and University Federico II, Naples, Italy;3Department of Translational Medical Science, University of Federico II, Naples, Italy;



P28 - KCTD1-Ap2α interaction: a crucial point in adipocyte differentiationLuciano Pirone1, Giovanni Smaldone2, Rossella Spinelli3,4, Vincenzo Quagliariello5, Gregory Alexander Raciti3,4, Claudia Miele3,4, Alfonso Barbarisi5, Francesco Beguinot3,4,Luigi Vitagliano1, Sonia Di Gaetano1, Emilia Pedone1*

1Istituto di Biostrutture e Bioimmagini, CNR, Napoli;2 IRCCS SDN, Napoli, Italy; 3URT dell'istituto di Endocrinologia e Oncologia Sperimentale “Gaetano Salvatore”, CNR, Napoli, Italy;4Dipartimento di Scienze Mediche Traslazionali dell'Università Degli Studi Di Napoli Federico II, Napoli, Italy;5Dipartimento scienze anastesiologiche, chirurgiche e dell'emergenza, Università della Campania-Luigi Vanvitelli, Caserta, Italy.

P29 - Combination of reduced MRNA splicing and protein secretion/function determines coagulation factor VIII expression in hemophiliaIrving Donadon1,2, John H. McVey3, Isabella Garagiola4, Mortarino Mimosa4, Alessio Branchini1, Flora Peyvandi4,5, Francesco Bernardi1, Mirko Pinotti1*

1Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy;2Human Molecular Genetics, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy;3School of Biosciences & Medicine, University of Surrey, Surrey, UK;4Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico and Fondazione Luigi Villa, Milan, Italy;5Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy;

P30 - The recognition mechanism of the coactivator NCoA-1 by STAT6Luigi Russo1,2*, Karin Giller2, Edith Pfitzner3, Christian Griesinger2, Stefan Becker2

1 Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 - Caserta, Italy;2 Department for NMR based Structural Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany;3 Friedrich-Schiller-University Jena, Institute of Biochemistry and Biophysics, Philosophenweg 12, 07743 Jena, Germany;

P31 - Zn(II) to Ni(II), Hg(II) and Pb(II) replacement in the prokaryotic zinc-finger domainValeria Sivo1*, Gaetano Malgieri1, Luigi Russo1, Gianluca D’'D5Abrosca1, Rosa Iacovino1, Anna Messere1, Ilaria Baglivo1, Paolo Vincenzo Pedone1, Roberto Fattorusso1

and Carla Isernia1

1Department of Environmental, Biological and Pharmaceutical Science and Technology, University of Campania “Luigi Vanvitelli”, Caserta, Italy;

P32 - Nanosubstrates modulate mechanotransduction processes in human islets of LangerhansGabriella Tedeschi1,4, Elisa Maffioli1,4, Carla Perego2, Fabiana Santagata1,4, Eliana Di Cairano2, Francesca Grassi Scalvini1,4, Silvia Morelli4, Cristina Lenardi31 DIMEVET; Università degli Studi di Milano, Milano, Italy;2 DISFEB; Università degli Studi di Milano, Milano, Italy;3 C.I.Ma.I.Na, Università degli Studi di Milano, Milano, Italy;4 Fondazione Filarete, Milano, Italy;



P33 - Exploring the kinetics of the self-assembly of an engineered archaeal ferritin proteinMatilde Trabuco1,2*, Irene Benni1, Lorenzo Calisti1, Cécile Exertier1, Alessandra Bonamore1, Valeria de Turris3, Beatrice Vallone4, Marco Cammarata5, Matteo Levantino6,Paola Baiocco3, Francesco Malatesta2, Alberto Boffi2,4

1MoLiRom srl., Rome , Italy;2Department of Biochemical Sciences “Alessandro Rossi Fanelli”,Sapienza University of Rome, Rome, Italy;3Center for Life Nano Science@Sapienza, Instituto Italiano di Tecnologia, Rome, Italy;4Institute of Molecular Biology and Pathology, National Research Council, Rome, Italy;5Institute of Physics University of Rennes 1, Rennes, France;6European Synchrotron Radiation Facility, Grenoble, France;

P34 - Altered protein O-GlcNAcylation profile revealed by proteomics in AD: Novel insights on protein signalling mechanisms and potential therapeutic targetsAntonella Tramutola1, Nidhi Sharma1, Eugenio Barone1, Tommaso Cassano2, Marzia Perluigi1 and Fabio Di Domenico1.1 Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy;2 Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy;

P35 - Biochemical and biophysical characterisation of calmodulin-like protein 19 (CML19), the Centrin 2 of Arabidopsis thaliana.Matteo Trande1, Valentina La Verde1, Mariapina D’Onofrio1, Paola Dominici1, Alessandra Astegno1*1Department of Biotechnology, University of Verona, Verona, Italy

Other - O

O1 - Molecular mechanisms for maintenance of genomic imprinting in mouse embryonic stem cellsBasilia Acurzio1,2, Andrea Oneglia1,2, Harpreet Kukreja1,2, Laura Pignata1,2, Carlo Giaccari1,2, Diletta Dolfini3, Roberto Mantovani3, Andrea Riccio1,2

1Instituto di Genetica e Biofisica ‘'A. Buzzati-Traverso’', CNR, 80131 Napoli, Italy,2Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli Studi della Campania Luigi Vanvitelli, 81100 Caserta, Italy;3Dipartimento di Scienze Biomolecolari e Biotecnologie,Università di Milano, 20133 Milano;

O2 - Scale up of the biotechnological process to produce two recombinant thermophilic phosphotriesterases of potential use in pesticide treatmentsMaria Giovanna Borzacchiello1, Odile Francesca Restaino1, Ilaria Scognamiglio1, Luigi Fedele1, Giuseppe Manco2, Chiara Schiraldi1*

1Experimental Medicine Department, University of Campania “L. Vanvitelli”, via De Crecchio 7, Naples, Italy;2Institute of Protein Biochemistry, National Research Council of Italy, via Castellino 111, Naples, Italy;



O3 - Erythrocytosis due to a quantitative decrease of VHL protein levels: clinical and molecular featuresMartina Caiazza1, Saverio Scianguetta1, Domenico Roberti1, Immacolata Tartaglione1, Maddalena Casale1, Fulvio Della Ragione2, Silverio Perrotta1

1 Department of Woman, Children and General and Specialized Surgery, Università degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy;2Department of Biochemistry, Biophysics and General Pathology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy;

O4 - a-Lipoic acid reduces iron overload induced by oxidative stressGiuseppina Camiolo1, Cesarina Giallongo1, Vincenzo Bramanti1, Giuliano Russo1, Lucia Longhitano1, Francesco Di Raimondo2, Giovanni Li Volti1, Daniele Tibullo1,Roberto Avola1

1Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy; Division of Haematology,2 A.O.U. "Policlinico-Vittorio Emanuele", University of Catania, Via Citelli 6, 95100, Catania, Italy;

O5 - Variation of Hypoxia Inducible Factor 1 alpha subunit (HIF-1£\) and Prolyl Hydroxylase Domain 2 (PHD2) transcripts in Toxoplasma gondii infection: apreliminary comparative analysisAnnamaria Castello1,2, *, G. Bruschetta2, R. Giunta1, A.M.F. Marino1, A.M. Ferlazzo2

1IZS, Catania;2Dept. of Veterinary Sciences, University of Messina, Italy;

O6 - Novel 1,2 benzoquinone-based derivatives suppress 5-lipoxigenase and induce endoplasmic reticulum stress-mediated cell death in human glioblastomaAlessia Maria Cossu1*, Silvia Zappavigna1, Peduto Antonella2, Scuotto Maria2, Marianna Abate1, Oliver Werz3, Mario De Rosa2, Rosanna Filosa2, Michele Caraglia1

1Department of Biochemistry, Biophysic and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy;2Department of Experimental Medicin, University of Campania “Luigi Vanvitelli”, Naples, Italy;3Medicinal Chemistry, Institute of Pharmacy, Friederich-Schiller-University, Jena, Germany;

O7 - Lignanamide enriched extract from hemp seed: quali- and quantitative LC HRMS analysis and cytotoxicity assessmentGiuseppina Crescente,* Francesca Pacifico, Antonio Fiorentino, Simona Piccolella, Severina Pacifico1Department of Environmental Biological and Pharmaceutical Sciences, University of Campania Luigi Vanvitelli, Caserta, Italy;

O8 - An example of dual nature: characterization of SIRC rabbit corneal cellsCristaldi Martina1, Melania Olivieri1, Gabriella Lupo2, Carmelina D. Anfuso2, Nunzia Caporarello2, Salvatore Pezzino3, Dario Rusciano1*

1Sooft Italia - FidiaPharma, Catania, Italy;2BIOMETEC, University of Catania, Catania, Italy;3Bioos Italia –'D0 FidiaPharma, Catania, Italy;

O9 - S-Adenosylmethionine Inhibits the Growth of Human Breast Cancer Cell by Promoting Autophagy and ApoptosisDonatella Delle Cave, Laura Mosca, Concetta Paola Ilisso, Martina Pagano, Elisa Martino, Giovanna Cacciapuoti and Marina Porcelli*Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Naples, Italy



O10 - Effects of T3 and 3,5 T2 on insulin sensitivity and related metabolic changes in muscle cells treated with fatty acidsGiuseppe delli Paoli1, Antonia Giacco2, Elena Silvestri2, Rosalba Senese1, Federica Cioffi2, Maria Moreno2, Antonia Lanni1, Fernando Goglia2, Pieter de Lange1*

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Study of Campania Luigi Vanvitelli, Caserta , Italy;2Department of Sciences and Technologies, University of Sannio , Benevento , Italy

O11 - A novel TetR-like transcriptional regulator is induced in acid-nitrosative stress and controls expression of an efflux pump in mycobacteria.1Barbara De Siena, 1Filomena Perrone, 1Lidia Muscariello, 2Sharon Kendall, 3Simon Waddell and 1Margherita Sacco1Depart. of Environmental, Biological and Pharmaceutical Sciences and Technologies (DiSTABiF), Univ. degli Studi della Campania Luigi Vanvitelli, Via Vivaldi 43, Caserta.2Dep. of Pathology and infectious Diseases, The Royal Veterinary College, Centre for Emerging, Endemic and Exotic Disease, Hawkshead Lane, Hertfordshire, AL97TA,UK.3Wellcome Trust Brighton and Sussex Centre for Global Health Research, Brighton and Sussex Medical School, University of Sussex, Brighton, BN1 9PX;

O12 - Allelic variants in α and β-globin genes of the river buffalo Bubalus bubalis L. as markers of useful genotype differentiationR. Rullo1*, E. De Vendittis2, R. Nasso3, A. Di Luccia4, E. Pieragostini51ISPAAM-CNR, Napoli, Italy;2Dip. Medicina molecolare e biotecnologie mediche, Università di Napoli Federico II, Italy,3Dip. Scienze motorie e del benessere, Università di Napoli “Parthenope”, Italy;4Dip. Scienze Agrarie, degli Alimenti e dell'Ambiente, Università di Foggia, Italy:5Dip. Emergenza e Trapianti di Organi, Università di Bari, Italy;

O13 - Determining the keratan sulfate contamination in animal origin chondroitin sulfate.Paola Diana1*, Odile Francesca Restaino1, Rosario Finamore1, Mario Vitiello, Mario De Rosa1, Chiara Schiraldi11Experimental Medicine Department, University of Campania “L. Vanvitelli”, via De Crecchio 7, Naples, Italy;

O14 - Novel Selective α V β5 Integrin Antagonist Hidden into an Anophelin Family ProteinSonia Di Gaetano1*, Domenica Capasso2, Luciano Pirone1, Annarita Del Gatto1, Daniela Comegna1, Laura Zaccaro1, Michele Saviano3,Bruno Arcà4, Emilia Pedone1

1 Institute of Biostructures and Bioimaging, CNR, Naples, Italy;2Department of Pharmacy, University of Naples Federico II, Naples, Italy;3 Institute of Crystallography, CNR, Bari, Italy;4Department of Public Health and Infectious Diseases, Division of Parasitology, “Sapienza” University, Rome, Italy;

O15 - Acute tadalafil administration increases plasma fatty acids without changes in inflammatory response in healthy menGuglielmo Duranti1, Roberta Ceci1*, Paolo Sgrò2, Luigi Di Luigi2, Stefania Sabatini11 Laboratory of Biochemistry of Movement2 Unit of Endocrinology, Università degli Studi di Roma “Foro Italico”, Department of Movement, Human and Health Sciences, Rome, Italy;



O16 - The binding of MeCP2 and major satellite transcript to chromocenters is mutually dependent and critical for heterochromatin organizationSalvatore Fioriniello1, Eva Csukonyi1, Carmela Zarrillo1, Arianna Brancaccio1, Federico Marracino2, Maria Rosaria Matarazzo1, Maurizio D'Esposito1,2,

Floriana Della Ragione1,2*

1 Institute of Genetics and Biophysics "A.Buzzati Traverso", CNR, via Pietro Castellino, 111, 80131, Naples Italy; 2 IRCCS Neuromed, Pozzilli (Is), Italy;

O17 - Effects of Neu3 sialidase activation on cardiac fibrosisGhiroldi A.1, Piccoli M.1, Garatti A.2, Biondi A.2, Tettamanti G.1, Menicanti M.2, Anastasia L.11Laboratory of Stem Cell for Tissue Engineering, IRCCS Policlinico San Donato; 2Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy;

O18 - Effects of sex differences in response to inflammation under cellular stress-mimicking conditionsa.Chiara Giacomelli1, Eleonora Da Pozzo1, Chiara Cavallini1, Claudia Martini1*

1Department of Pharmacy, University of Pisa, Pisa, Italy;

O19 - Comparative proteomic approach of mitochondrial proteins in a mouse model for creatine transporter deficiencySerena Lacerenza1, Claudia Boldrini1, Angelo Molinaro2, Federica Ciregia1*, Laura Barocelli2, Maurizio Ronci3, Andrea Urbani4 , Maria Rosa Mazzoni1, Tommaso Pizzorusso2,Antonio Lucacchini1, Laura Giusti11 Department of Pharmacy, University of Pisa, Pisa, Italy;2 Institute of Neuroscience, National Research Council, Pisa, Italy;3 Department of Medical, Oral and Biotechnological Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy;4 Istituto di Biochimica e Biochimica Clinica, Università Cattolica, Rome, Italy;

O20 - 3,5-diiodothyronine (T2) induces browning of white adipose tissue through different pathwaysIannucci Liliana Felicia1, Senese Rosalba1, Cioffi Federica2, de Lange Pieter1, Leanza Cristina1, Goglia Fernando2 and Lanni Antonia1*

1Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università degli studi della Campania ‘'Luigi Vanvitelli”, Caserta, Italy;2 Dipartimento di Scienze e Tecnologie, Università degli studi del Sannio, Benevento, Italy;

O21 - Non-Coding RNAs Regulated by S-Adenosylmethionine: New Strategies for Pharmacological Treatment of Breast CancerConcetta Paola Ilisso, Donatella Delle Cave, Laura Mosca, Elisa Martino, Martina Pagano, Daniela C. Vuoso, Michele Caraglia, Giovanna Cacciapuoti, Marina Porcelli*Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Naples, Italy;

O22- Synergic effect of curcumin and ellagic acid on genomic stability of human amniotic cellsConcetta Iovine1, Filomena Mottola1, Marianna Santonastaso2, Nicola Colacurci2, Massimo Ferrara1, Veronica Feola1, Federica Farina1, Lucia Rocco1*

1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Study of Campania Luigi Vanvitelli, Caserta , Italy;2Department of DBC, University of Campania Luigi Vanvitelli , Naples, Italy;



O23 - MicroRNA-449a as powerful biomarkers and a therapeutic target of nodal metastases in laryngeal cancer patientsHiromichi Kawasaki1,2, Angela Lombardi1, Rosanna Capasso1, Gabriella Misso1, Filippo Ricciardiello3,4, Teresa Abate3, Maurizio Iengo3, Domenico Testa5, DomenicoNapolitano4, Gaetano Motta5, Marco Fornili6, Elia Mario Biganzoli6, Diego Ingrosso1, and Michele Caraglia1*

1Department of Biochemistry, Biophysics, and General Pathology, University of Campania Luigi Vanvitelli,2Drug Discovery Laboratory, Wakunaga Pharmaceutical Co., Ltd.,3Department of Ear Nose and Throat Unit, University of Naples Federico II,4Department of Ear Nose and Throat Unit, Cardarelli Hospital,5Naples Department of Ear Nose and Throat Unit, University of Campania Luigi Vanvitelli,6Department of Clinical Science and Community Health, University of Milan.

O24 - β-Sitosterol Reduces the Expression of Chemotactic Cytokine Genes in Cystic Fibrosis Bronchial Epithelial CellsIlaria Lampronti1*, Maria Cristina Dechecchi2, Alessandro Rimessi3, Valentino Bezzerri2, Alessandra Guerrini1, Anna Tamanini2, Silvia Munari2, Gianni Sacchetti1,Paolo Pinton3, Roberto Gambari1, Giulio Cabrini21Department of Life Sciences and Biotechnology, University of Ferrara, Italy;2Laboratory of Molecular Pathology, Department of Pathology and Diagnostics, University Hospital of Verona, Verona, Italy;3Department of Morphology Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of AdvancedTherapies (LTTA), University of Ferrara, Ferrara, Italy;

O25 - Alternatively spliced EDA fibronectin plays a key role during bone marrow regenerationAlessandro Malara1,2, Christian Gruppi1,2, Luigi De Marco3, Andrés Muro4, Alessandra Balduini1,2*

1 Department of Molecular Medicine, University of Pavia, Pavia, Italy.2 Laboratory of Biotechnology, IRCCS San Matteo Foundation, Pavia, Italy;3Department of Translational Research, National Cancer Center (IRCCS CRO), Aviano, Italy ,4 The International Centre for Genetic Engineering and Biotechnology, Trieste, Italy;

O26 - Annurca apple polyphenols induce cell cycle arrest and apoptosis in human breast cancer cells by increasing oxidative stressElisa Martino1, Stefania D'Angelo2, Concetta Paola Ilisso1, Donatella Delle Cave1, Laura Mosca1, Martina Pagano1, Marina Porcelli1 and Giovanna Cacciapuoti1*

1Department of Biochemistry, Biophysics and General Pathology, University of Campania “Luigi Vanvitelli”, Naples, Italy;2Department of Motor Sciences and Wellness, Parthenope University;

O27 - Urtica dioica: a new promising tool in chemotherapies strategies against non-small cell lung cancer (NSCLC)Giovanni Mastroianni1, Floriana Morgillo2, Vittoria Graziani1, Odeta Celaj1 Fortunato Ciardiello2, Antonio Fiorentino2, Brigida D’'D5Abrosca*1,1Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche - DiSTABiF, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta, Italy;2Dipartimento Medico-Chirurgico di Internistica Clinica e Sperimentale “F. Magrassi - A. Lanzara”, Università degli Studi della Campania “Luigi Vanvitelli” I-80131 ViaPansini, 5 - Napoli, Ital



O28 - Placental expression of nitric oxide synthase and vascular endothelial growth factor in obese pregnant womenEleonora Salvolini1, Arianna Vignini1, Guendalina Lucarini2, Jacopo Sabbatinelli1, Anna Maria Cester1, Andrea Ciavattini1, Monica Emanuelli1, Laura Mazzanti1*

1Department of Clinical Sciences, Università Politecnica delle Marche, Ancona, Italy;2Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy;O29 - Antiproliferative Effect of the Methyl Donor S-Adenosylmethionine in Oral Tongue Cancer CellsLaura Mosca, Martina Pagano, Concetta Paola Ilisso, Donatella Delle Cave, Elisa Martino, Giovanna Cacciapuoti, Marina Porcelli*Department of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Naples, Italy;O30 - Effects of HDAC Inhibitors on Glioblastoma CellsOlga Pastorino1,2, Maria Teresa Gentile1, Lucia Verrillo1, Maria Patrizia Stoppelli2, Luca Colucci D’'D5Amato1*1Laboratory of Molecular and Cellular Pathology, Di.S.T.A.Bi.F., University of Campania “L. Vanvitelli”, Caserta, Italy;2SignalTransductionLaboratory, IGB ABT, CNR, Naples, Italy;O31 - Human Cryptic Host Defence Peptides: identification and analysis of their antimicrobial, anti-biofilm and immunomodulatory propertiesEugenio Notomista1, Andrea Bosso1, Katia Pane1, Anna Zanfardino1, Mario Varcamonti1, Emilia Pedone2, Angela Arciello3, Edwin Veldhuizen4, César de la Fuente-Núñez5,Maria Rosaria Catania6, Valeria Cafaro1, Alberto Di Donato1, Elio Pizzo1*

1Department of Biology, University of Naples Federico II, 80126 Naples, Italy;2IBB, CNR, 80134, Naples, Italy;3Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy;4Department of Infectious Diseases and Immunology, Utrecht University, 3584 CS Utrecht, Holland;5Synthetic Biology Group, MIT Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA;6Department of Molecular Medicine and Medical Biotechnologies, Federico II University, 80131 Naples, Italy;O32 - A new tool to profile the UDP-sugar precursors of microbial capsular polysaccharides.Odile Francesca Restaino1*, Irene di Lauro1, Mario De Rosa, Chiara Schiraldi11Experimental Medicine Department, University of Campania “L. Vanvitelli”, via De Crecchio 7, Naples, Italy;O33 - Optimization of Hyaluronan-based Eye Drop FormulationsRosanna Salzillo, Chiara Schiraldi*, Luisana Corsuto, Antonella D’'D5agostino, Mario De Rosa, Annalisa La Gatta*Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy;O34 - A new strategy nanoparticle-based for personalized lymphoma therapyGennaro Sanità1*, Nunzia Migliaccio1, Nicola Martucci1, Gaetano Calì2, Ivo Rendina3, Paolo Arcari1, Annalisa Lamberti11Department of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, Italy;2Institute of Endocrinology and olecular Oncology, National Research Council, Naples, Italy;3Institute for Microelectronics and Microsystems, National Research Council, Naples, ItalyO35 - MiR-34a : a new potential therapeutic in Multiple Myeloma to enhance antitumor activity of anticancer drugsMayra Rachele Zarone1,* Gabriella Misso1, Anna Grimaldi1, Margherita Russo1, Carmela Ferri1, Michele Caraglia1

1Department of Biochemistry, Biophysics and General Pathology of University of Campania Luigi Vanvitelli, Naples, Italy;


Thursday, September 21 • PARALLEL SESSIONS • 16.30 - 18.00

SESSION1: Proteins session 1 AULA 1, Ground FloorChairs: Antimo Di Maro - Università degli Studi della Campania “Luigi Vanvitelli”, Caserta

Emilia Pedone - Istituto di Biostrutture e Bioimmagini (IBB) - CNR, Napoli

1 YFHJ is a modulator of the frataxin function in bacteria Salvatore Adinolfi2 Novel human bioactive peptides identified in Apolipoprotein B Angela Arciello3 New insights on the functional role of URG7 in the cellular response to ER stress Maria Francesca Armentano4 Successful Antibody Humanization Requires Grafting of Key Structural Residues Veronica Morea5 Characterization of novel inhibitors of CDC25 phosphatases: biochemical and biological analysis Rosarita Nasso6 Structural Insights into the Molecular Function of Human [2Fe-2S] BOLA3- GRX5 and [2Fe-2S] BOLA1-GRX5 Veronica Nasta7 Insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae Luciano Pirone8 New clues into self-assembly of the fungal hydrophobin Vmh2 Alessandra Piscitelli9 Methionine y-lyase as Anti-Cancer Biologics Samanta Raboni10 Biological activities of the ribotoxin Ageritin from Agrocybe aegerita (V. Brig.) Singer Sara Ragucci11 Human Histidine decarboxylase: a potential redox-modulated protein? Giada Rossignoli12 Protein Production Platform @ Elettra: Overcoming the bottleneck Paola Storici

SESSION 2: Proteins session 2 and Computational and Systems Biology AULA 4, Ground FloorChairs: Rosaria Medda - Università di Cagliari, Cagliari

Maurizia Valli - Università di Pavia, Pavia

1 Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT rich DNA core target site and oligomerization ability Ilaria Baglivo2 Pyrene-labelled ferritin as an excimer fluorescence based probe to study protein oligomerization Irene Benni3 New insights into the polyubiquitin gene UBC transcriptional regulation under oxidative stress Marzia Bianchi4 Cancer-associated fibroblast metabolism may control epigenetic regulation via protein acetylation Claudia Boldrini5 Proteomic signature in genetic disorders of propionate metabolism Marianna Caterino6 Provirus integration leads to CRISPRmediated autoimmunity in Sulfolobus solfataricus Salvatore Fusco7 Proteotoxicity in cardiac amyloidosis through a proteome profiling of human heart cells exposed to amyloidogenic light chains Esther Imperlini8 Adiponectin expression is specifically related to Common variable immunodeficiency Rita Polito9 Deciphering molecular aspects of Mycobacterium tuberculosis DNA repair by biochemical and structural studies Franca Rossi10 UPLC/MRM MS Quantification of Trastuzumab in Human Serum by Selective Monitoring of a Specific Peptide Marker from the

Antibody Complementarity-Determining Regions Rosita Russo11 Discovery and validation of pharmacological chaperones Valentina Citro12 Antiproliferative effects of novel synthetic nucleobase analogues on U937 Histiocytic lymphoma cell line Alessandro Trentini

(Università degli Studi della Campania “Luigi Vanvitelli” Polo di Viale Ellittico 31, Caserta)Short talks selected from submitted abstracts


SESSION 3: Differentiation and Neoplastic Transformation AULA 8, First FloorChairs: Rita Santamaria - Università di Napoli “Federico II”, Napoli

Alessandro Giuffrè - Istituto di Biologia e Patologie Molecolari (IBPM) - CNR, Roma

1 Nandrolone affects cell growth and differentiation in hepatoma cells Francesca Agriesti2 Interleukin-6 induced astrocytic differentiation modulates Mannose Binding Lectin (MBL)-Associated Serine Protease (MASP)-1

and MASP-3 expression in C6 glioma cells Rosaria Arcone3 CDKN1B gene alterations and human cancers: mechanicistic investigations on G9R missense mutation Debora Bencivenga4 CLU expression negatively modulates NF-kB activity Martina Bonacini5 FPR1 modulates endothelial cell functions by VEGFR2 transactivation Fabio Cattaneo6 The anti-apoptotic BAG3 protein is involved in BRAF inhibitor resistance in melanoma cells Margot De Marco7 Heparan sulfate proteoglycans as novel target in cancer precise therapy Chiara Falciani8 Mitochondrial “Power” Drives Tamoxifen Resistance: NQO1 and GCLC Are New Therapeutic Targets in Breast Cancer Marco Fiorillo9 Protein moonlighting in cancer cells: TRAP1 and Syndesmos regulate translation and mitochondrial function Danilo Swann Matassa10 Epidermal Growth Factor Receptor Signaling in a Cellular Model of Mucopolysaccharidosis IIIB Luigi M. Pavone11 p57Kip2 in cell biology: protein kinase network in the modulation of its phosphorylation pattern Emanuela Stampone12 Heme oxygenase 1 protects myeloma cells against bortezomib through nuclear translocation and regulation of er stress and

autophagy proteins Daniele Tibullo

SESSION 4: Aging and Degenerative Diseases - Nutrition and Environment AULA 7, First FloorChairs: Maria Luisa Balestrieri - Università degli Studi della Campania “Luigi Vanvitelli”, Caserta

Loredana Mariniello - Università di Napoli “Federico II”, Napoli

1 Analysis of protease levels in brain samples from Alzheimer’s patient Silvia Bartollino2 NLRP3 inflammasome activation in ALS mouse model Ilaria Bellezza3 Ab42 oligomers interact with GM1 ganglioside inducing neuronal calcium 6 Hypoxia induces ROS decrease in primary human

dermal fibroblasts Alessandra Bigi4 Role of peptide from Mozzarella di Bufala Campana DOP (MBCP) on intestinal barrier breakdown associatedto the inflammation

process Stefania Lama5 Mitochondrial citrate carrier deficiency causes neuromuscular transmission impairment Pasquale Scarcia6 Hypoxia induces ROS decrease in primary human dermal fibroblasts Gianluca Sgarbi7 Alteration of endothelial extracellular matrix in inflammation Manuela Viola8 Evolution of sulfhur-containing compounds: From life in the ocean to pharmacological applications Immacolata Castellano




9 Platform chemicals from Basfia succiniciproducens BPP7 growing on lignocellulosic biomasses up to the prepilot scale Donatella Cimini10 Effects of a fasting mimicking diet (FMD) on peripheral blood lipid profile in cancer patients Paola A. Corsetto11 Effect of selected lactic acid bacteria on antioxidant and anti-inflammatory properties of sourdough Simone Luti12 Expression, chromatin accessibility and DNA methylation of sirtuin genes in nutrient-restricted murine hepatoma cell line Alberto Zullo

SESSION 5: Membranes and Other Contributions AULA LICCARDO, Ground FloorChairs: Maria Basile - Università di Bari “Aldo Moro”, Bari

Gabriella Fiorentino - Università di Napoli “Federico II”, Napoli

1 Novel diacylglycerol kinase alpha inhibitors for X-linked lymphoproliferative disease 1 therapy Gianluca Baldanzi2 New insight into the A2b adenosine receptor effects on epithelialmesenchymal transition in human epithelial lung cells Simona Daniele3 Involvement of sAC-dependent cyclic- AMP in mitochondrial dysfunction of nephropathic cystinosis Domenico De Rasmo4 Ablation of type VI collagen leads to megakaryopoiesis defects Vittorio Abbonante5 Purification and characterization of extracellular nanostructures from N.sp. PP1Y: a novel example of Outer Membrane Vesicles Viviana Izzo6 Advancements in Hyaluronan Chemical Modification: Relevance to Tissue Engineering and Other Biomedical Applications Annalisa La Gatta7 Nucleolipidic-based liposomes effectively deliver a Ru(III) complex across cell membranes to nuclei promoting in concert apoptosis

and autophagy in human models of breast cancer Marialuisa Piccolo8 A combined treatment approach of p53 null colon cancer cells based on 5-FU plus the proapoptotic rpL3 gene Annapina Russo



INFORMAZIONI GENERALI

Sedi CongressualiAuditorium della Scuola Specialisti Aeronautica MilitareViale Ellittico, 33 - Caserta (vicino alla Reggia di Caserta)

Università degli Studi della Campania “Luigi Vanvitelli”Polo di Viale Ellittico, 31 - Caserta

Mensa Scuola Specialisti A. M.

Auditorium Scuola Specialisti A. M.

Università degli Studi della Campania“Luigi Vanvitelli”

Viale Ellittico, 31

Viale Ellittico, 33

Lunches150 m. - 5 min.

130 m. - 4 min.

Segreteria OrganizzativaG.P. Pubbliche Relazioni s.r.l.Via San Pasquale a Chiaia, 55 - 80121 NapoliTel. 081 401201 - Fax 081 404036e-mail: [email protected] site: www.gpcongress.com

INFORMAZIONI GENERALI

Visita agli Appartamenti della Reggia di Caserta e Welcome CocktailSi terranno Mercoledì 20 settembre dalle ore 17.00, con trasferimento a piedi dalla Sede Congressuale. Il Welcome Cocktail si svolgerà,dopo la visita guidata della Reggia, presso il Consorzio della Mozzarella di Bufala - Regie Cavallerizze, Via Raffaele Gasparri, 1, Reggiadi Caserta. Si fa presente che è possibile lasciare l’auto all’interno del parcheggio della Sede Congressuale fino al rientro dal Cocktail.

LunchesSi terranno nei giorni Giovedì 21 e Venerdì 22 Settembre presso la Mensa della Scuola Specialisti Aeronautica MilitareViale Giulio Dohuet, 2 - CasertaN.B. Si fa presente che per l’accesso alle Sedi dell’Aeronautica Militare è obbligatorio indossare il badge con il nome ed il codicea barre per l’identificazione da parte del personale addetto agli Ingressi.

Social Dinner e Assemblea Soci SIBSi terranno Giovedì 21 Settembre presso la Masseria Giò Sole - Via Giardini, 31 - Capua (Ce).Partenza dei Bus dalla Sede Congressuale: ore 18.15. Si fa presente che è possibile:• lasciare l’auto all’interno del parcheggio della Sede Congressuale fino al rientro dalla cena• raggiungere la Masseria Giò Sole con la propria auto

Sessione PosterLa sessione Posters si svolgerà presso la Biblioteca della Università della Campania “Luigi Vanvitelli” sita al Piano Terra - Viale Ellittico,31, Giovedì 21 settembre dalle ore 15.30 alle ore 18.00. I Posters, i cui numeri di assegnazione vanno verificati sul programma, potrannoessere allestiti dalle ore 9.00 di Giovedì 21 settembre e rimossi entro le ore 18.00. Il materiale necessario per l’allestimento saràdisponibile presso l’area Poster.

Presentazioni Orali (selezionate dalla sottomissione degli Abstracts)Si terranno Giovedì 21 settembre dalle ore 16.30 alle ore 18.00 in contemporanea alla Sessione Posters presso le Aule dell’Universitàdella Campania “Luigi Vanvitelli” - Viale Ellittico, 31.Si prega di verificare sul programma l’Aula dove è previsto lo svolgimento della Sessione assegnata.

Centro SlidesIl Centro Slides è situato all’interno dell’ Auditorium affianco al Tavolo dei Relatori.È necessario consegnare ai tecnici la pen-drive almeno 30 minuti prima dell’inizio della propria sessione.

Caserta, September 20 – 22, 2017

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