2013A N N U A L R E P O R T

Technology Transfer from the University of Oxford

Enabling Access to Oxford’s academic expertise

Global innovation management consultancy

Chairman’s Introduction 1

Review of the Year 2

Technology Transfer 4

Oxford University Consulting 6

Isis Enterprise 8

Software Commercialisation 10

Networks and Partnerships 12

Communications 13

Accounts 14

Company Details 16

25 years of technology commercialisation

This report highlights the achievements of the financial year 2012-13. The report presents the breadth and depth of expertise within Isis, working with colleagues across the University and with our external clients across the key technology areas and sectors of the economy. This is our 25th year, a significant milestone. Over the years the impact of our activities has grown significantly in a wide range of areas. A summary of key successes during this time is available in a special brochure, on our website, www.isis-innovation.com.

Contents

Cover: Isis works with researchers across the University. Main picture : Department of Chemistry

Delivering consultancy to companies, governments, and technology

transfer organisations worldwide.

Managing the commercialisation of IP developed in Oxford – licensing,

spin-outs and material sales.

The latest innovations, collaborations and technology transfer

25Isis insights

Providing access to academic consultancy and services from

the University of Oxford.

www.isis-innovation.com

1

Chairman’s Introduction

OUC is now well established in the University and has facilitated many hundreds of consulting relationships between academics and clients, often leading to long term collaborations.

Isis Enterprise continues to promote and sell our expertise around the world, helping technology providers and seekers to source, commercialise and develop new technologies. In addition, Isis Enterprise assists governments and other organisations interested in establishing their own innovation activities.

This report is my last as Chairman of Isis Innovation. I have been a member of the Isis Board for sixteen years and Chairman for twelve years during which time the company has grown from a handful of staff with modest revenues to the position described in this report with more than eighty staff and revenue of nearly £12m. Also the company has played an important part in changing the culture to one where innovation and technology transfer is seen universally as a good thing. This was not the case even ten years ago. I have enjoyed my time at Isis very much and it has been a huge pleasure to work with my fellow directors, the staff of Isis, and all those within the University involved with Isis. I am delighted to be succeeded as Chairman by my fellow director, Nigel Keen. Nigel has been on the board for seven years, he understands the innovation process better than anyone and I wish him and the company every success in the future.

I would like to close by thanking everyone at Isis Innovation for their support and hard work this year and throughout my time as Chairman.

Isis Innovation Ltd is a growing and successful business owned by the University of Oxford. Oxford is the biggest research-based University in the UK, with research expenditure of £542m last year. Isis acts as the fund manager of the University’s Intellectual Property, investing in and managing the portfolio of two thousand patent protected inventions arising from the University’s research activities; and then transferring the IP to industry for further investment and development around the world.

Isis revenues increased by 13% to £11.5m with growth across all areas of the business. This continues our record of impressive annual business performances during a period of exceptional economic challenges in many regions. The international reach of Isis, with offices in Oxford, Madrid, Hong Kong and Kyoto, attracts investment into Oxford technologies from established companies and financial investors around the world, and supports the growing technology transfer and innovation management consulting business.

Isis continues to deliver a positive return on investment to the University each year. The University provides Isis with £2.5m to invest in protecting intellectual property arising from the University’s research activities. This involves managing a strong portfolio of international patents (2105), technology licensing deals (644) and new company formation (70). This year Isis generated a return to the University and its researchers of £5.6m, and created shareholdings for the University in four new spin-out companies worth £0.5m.

Technology commercialisation is of growing importance to the University, to research funders, to governments and the economy. Translating the outputs of early stage research from universities to the business environment allows novel ideas to become new products which address current challenges in healthcare, the environment and communications.

Oxford University Consulting has had a very successful year connecting the expertise of Oxford’s academic community to client organisations around the world.

This year Isis generated a return to the

University and its researchers of £5.6m, and

created shareholdings for the University in

four new spin-out companies worth £0.5m.

Bernard Taylor, Chairman

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Isis delivered another very strong performance in 2013, transferring new ideas out to industry, generating financial returns and delivering impact for the University.

Over the year, Isis returned £5.6m to the University and its researchers (an increase of 6% overall from 2012). Isis provided the University with shareholdings in four new spin-out companies (valued at £0.5m) and six new software start-ups; invested £3.27m in protecting University intellectual property, increased the University’s assets by 105 new patent applications, and assisted Oxford researchers in winning translational funding awards totalling £22m. This was the final year of the 2009 to 2013 five year growth plan for Isis, with Isis receiving from the University an annual subvention of £2.5m. The University has increased investment levels to £3.1m under the new plan.

Revenue growthIsis revenues increased by 13% to £11.5m (2012: £10.2m). This is an impressive business performance during a year of continued challenging circumstances from the global financial crisis.

• The Technology Transfer Group revenues increased by 5% to £6.7m (2012: £6.4m).

• Oxford University Consulting revenues increased by 31% to £2.5m (2012: £1.9m).

• Isis Enterprise revenues increased by 31% to £2.1m (2012: £1.6m).

Isis is responsible for these activities:

Technology Transfer for OxfordIsis helps Oxford University researchers to commercialise intellectual property arising from their research through patenting, copyright, licensing, spin-out companies, research reagents and patient reported outcome measures. Isis manages the following:

Isis Angels NetworkIAN introduces private investors and seed/venture capitalists interested in investing in Oxford spin-out companies to investment opportunities, on behalf of the University.

Oxford Invention Fund & Oxford University Challenge Seed Fund Isis manages these funds on behalf of the University to provide financial investment for accelerating the transfer of Oxford technologies to market.

Isis Software IncubatorThe incubator supports Oxford University staff and students to develop software business ventures by offering specific technical and commercial advice, and allowing incubatees to develop their products and start trading.

Oxford University Consulting (OUC)Isis manages OUC which helps Oxford University researchers to identify and manage consulting opportunities and helps clients access expertise from Oxford’s world-class, interdisciplinary research base.

Oxford Innovation SocietyIsis runs the Oxford Innovation Society, a leading forum for open innovation, bringing together industry, investors, government and the business professions with researchers and inventors from the University.

Isis EnterpriseIsis provides consulting expertise and advice in technology transfer and innovation management to clients across the public and private sectors around the world.

Tom Hockaday, Managing Director

Review of the year

3

Total Isis revenues in 2013 (2012: £10.2m)

£11.5

REVENUES

Patents and patent applications on Oxford inventions managed by Isis (includes 873 granted patents)

2015PATENTS

New companies supported by the Isis Software Incubator (2012: 3)

6SOFTWARE START-UPS

Translational research funding won by Oxford researchers with direct Isis support

Technology Licence (98) and Oxford University Consulting (297) deals signed (2012: 356)

£22

395

TRANSLATIONAL FUNdINg

dEALS

Returned to Oxford University and its researchers (2012: £5.3m)

£5.6

£9.3

mIL

LIO

Nm

ILLI

ON

dISTRIbUTIONS

Isis is a world leading technology transfer business, creating links between the outstanding research capability at Oxford, and elsewhere, for the benefit of society in the UK and around the world. Isis provides opportunities for business that creates sustainable economic growth and for the University of Oxford to demonstrate substantial impact from its research activities.

New technology spin-outs created by Isis (2012: 5)

4SPIN-OUTS

Total amount awarded to develop Oxford research from Proof-of-Concept and seed funds managed by Isis Innovation

SEEd FUNd AWARdS

mIL

LIO

Nm

ILLI

ON

Isis Highlights

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Technology Transfer

The Technology Transfer group commercialises University of Oxford intellectual property through patenting, licensing and material sales. Isis holds a portfolio of more than 2000 patents and patent applications, with more than 650 active licensing deals and 70 completed spin-outs. A close and highly-valued working relationship with colleagues in Research Services ensures that IP is correctly assigned and handled.

Improving vaccine effectiveness

Oxford Vacmedix, one of this year’s spin-outs, offers the potential to significantly reduce the cost of vaccine development and to increase the effectiveness of vaccines in providing immunity against both infectious diseases and cancer.

The technology makes use of techniques that have already produced effective vaccines under laboratory conditions - manufacturing new ‘overlapping peptide’ vaccines using a natural expression system. A team from the University of Oxford, Department of Oncology and the Weatherall Institute of Molecular Medicine led by Dr Shisong Jiang is responsible for the promising technology.

International collaboration

An increasing number of Oxford spin-outs are created with international partners, this formation is a fine exemplar. The UK company formed a joint venture in Hong Kong with Chinese investors, enabling the majority of the early stage validation of the Oxford technology to be undertaken at the Changzhou Biopharmaceutical Incubator, supported by Chinese private investment and government funding. The joint venture company is focused on the Chinese market, and is eligible to access up to 2 million RMB in funding from the Changzhou Government.

Describing the advantages of their work, Dr. Jiang said:

“The present way of making overlapping peptides is to chemically synthesise all the peptides. The use of the peptide synthesiser, and the limited quantity of peptides produced in this way, made the overlapping peptides very expensive to produce.”

“In contrast, our new method of making overlapping peptides in a bacterial system will allow us to obtain the

Avian flu, strain H5N1. Coloured transmission electron

micrograph (TEM) of influenza A virus particles (red) in MDCK

culture cells.

recombinant protein and then the overlapping peptides endlessly. It is a great improvement compared with the previous method.”

“There are two clear advantages to this approach to developing new vaccines. Firstly, we expect that this technique will allow us to design an effective vaccine much more quickly than using standard vaccine development methods. Secondly, these vaccines can be made using recombinant techniques, potentially a thousand times cheaper than the current solid-phase synthesis processes used to manufacture similar vaccines.”

The best of both worlds

The CEO and investor, Dr Hong Hoi Ting, who will be leading the business and technology validation said: “We are extremely excited about the opportunity to commercially develop this Oxford technology in a region where its potential impact on healthcare is huge. This business allows us to continue building links between Oxford and China, taking advantage of the best of both and to realise the commercial potential in the technology.”

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Solar materials

Isis spin-out Oxford PV continued to make great progress in developing products for Building Integrated Photovoltaics applications, including additional recently licenced Oxford technology that gives best in class efficiency and promises the lowest cost per Watt generated in the field of photovoltaics. Construction of a new product development centre is being funded by a successful £2.7m investment round.

Hot enough?

Assessing the spiciness of chilli peppers in food has traditionally been performed by a panel of human tasters. Oxford researchers have invented a sensitive electroanalytical methodology for the determination of capsaicin using adsorptive stripping voltammetry (ASV) with multi-walled carbon nanotube (MWCNT) based electrodes.

The chilli tester has been found to be particularly useful for quality assurance in the food industry; food producers can check raw materials and finished products

using this fast and simple method. Isis has a licence agreement with Singapore-based partner, Bio-X, to commercialise the chilli tester, and Bio-X is currently working with a number of customers and electronics suppliers to build the chilli tester units

Reducing statin side effects

Having signed an exclusive US licence with Isis for a genetic biomarker for statin induced myopathy in 2011, US-based Boston Heart Diagnostics successfully developed the diagnostic test and launched it in the US market this year.

Many patients benefit from statin therapy, which effectively lowers cholesterol and results in a substantial reduction in heart attacks and stroke. This diagnostic test identifies those who are at risk of a side effect known as myopathy, a condition that causes significant pain, therefore allowing clinicians to make better choices about cholesterol lowering treatments..

PROs

Isis Outcomes again saw rapid growth in the last year (4th year running) with revenues up 40% on the previous year, taking the business into profit. With 331 licenses signed last year, Isis Outcomes continues to expand its provision and support of high quality patient reported outcome (PRO) measures. These PRO measures are increasingly being adopted and recognised by the pharmaceutical industry, medical device manufacturers, healthcare providers and academia as essential tools in quantifying the benefit of medical interventions.

Researchers in the Chemistry Department developing the

Chilli Sensor

Colour range of solid state dye sensitised solar cells

6

Oxford University Consulting

Oxford University Consulting (OUC) became part of Isis Innovation in 2002, with responsibility for assisting academics and researchers to engage in consultancy activities and for supporting University departments to make their facilities and resources available to external organisations. Today, OUC has over 1,000 consultants on its books, drawing together expertise from across the University. We negotiate around 300 client contracts a year.

Expertise in action

Oxford University’s Department of Education has made a major contribution to the study of education for over 100 years and today it has a world class reputation for teaching and research in this field. The Department maximises its research impact by applying its expertise to provide consultancy services to governments, NGOs and commercial organisations.

OUC put in place the contractual framework to support a ‘Leadership for Learning’ programme being delivered to Oxford City Council. This two-year programme for primary schools involves up to 40 staff and governors each receiving up to 12 training days a year from leading national and international researchers and practitioners.

The programme is being provided through a collaboration between the University of Oxford’s Department of Education and Oxford Brookes University’s School of Education. On completion of the programme, each participant will be eligible to receive accreditation towards a Master’s degree (20 module credits towards the 180 credits required for a Master’s degree).

The University in the community

This programme is a fine example of a mutually beneficial relationship between the University and the local community. Programme Director Ian Menter, Professor of Teacher Education and Director of Professional Programmes at Oxford University, said: “We hope that through the Leadership for Learning programme, teachers and governors will be able to tap into a pool of expertise and support each other and that this will help them to develop new leadership strategies. By working

in this way, and building upon many recent positive developments, the quality of teaching in our primary schools should continue to improve.”

Across the Social Sciences Division, OUC has seen a steady increase in the number and diversity of consultancy projects. In the last three years, we have managed more than 150 Social Science projects, successfully contracting work for more than 250 academic consultants.

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mind the gap

The efficiency of jet engines can be improved through tighter clearance between the tip of the rotating blade and the casing. Helping with the design of an eddy current sensor, capable of operating at temperatures in the order of 1500-1600K, formed the basis of an OUC consultancy project for Qinetiq, undertaken by Kam Chana from the Department of Engineering Science.

Flight consultants

OUC works with the Oxford Animal Flight Group to apply their expertise in biological sensors and actuators, low-speed aerodynamics, flapping flight, passive flow control, and acoustic noise reduction. This year, clients ranged from a film production company needing studio support to better handle insects being filmed for a 3D documentary on insect flight, through to aerospace companies seeking to learn lessons from nature in the area of flight dynamics

Access to services

OUC continues to be active in arranging laboratory service contracts with external organisations on behalf of University departments. Through OUC, the Central Proteomics Facility at the Sir William Dunn School of Pathology is providing analytical services to Allergy Therapeutics, a European-based speciality pharmaceutical company focused upon the treatment and prevention of allergy.

“The services have increased characterisation of our produc ts to a more advanced leve l us ing cut t ing e dge ana l y t i ca l p ro ce dures .” according to the client’s Development Scientist, James Hutchings. “This has al lowed a deeper understanding of drug mechanisms, thus facilitating our route to product registration and ensuring a safe and efficacious product is manufactured and released.”

Services work is important because clients not only gain access to a range of equipment and techniques but also benefit from the expertise of the teams that run the facilities in the University - frequently active researchers, working at the cutting edge of their fields. In return, as well as income, departments develop relationships that may lead to future collaborative research, whilst contributing to the wider research impact agenda by maximising use of equipment and facilities.

Phot

o: S

imon

Wal

ker

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Towards an innovative future

As universities throughout the world seek, and are required, to play a more active role in their regional economies there is a growing need for entrepreneurial skills learning at all levels. Governments and businesses recognise the need for innovation to stimulate economic growth. This brings universities to the fore - creating demand for basic and applied research, consultancy and training.

Transformation in practice

Isis Enterprise is working with the University of Malta (UoM) to build and support the local innovation ecosystem, to consolidate a knowledge transfer framework and to launch a formal training programme in technology entrepreneurship. The overall goal of the programme is to assist the UoM to achieve its goal of transforming itself into an entrepreneurial University.

Recognising that transformation does not happen overnight, a roadmap of activities and support was agreed to develop a knowledge transfer framework around the themes of business collaborations, consultancy services, technology transfer and business incubation.

Together these strands will deliver support to business by providing research, innovation and skills, support to the UoM and its individual researchers by making their expertise and resources more accessible, and support to the economy by creating business growth through licensing and formation of new companies.

Qualified students of the programme also gain credits which can be used towards the award of a Master in Entrepreneurship.

From theory to practice

The programme in technology entrepreneurship has been launched with its first group of students. Isis Innovation consultants have provided ten external and internal seminars, and are supporting the local ecosystem and UoM by providing advice on the most appropriate structures and processes of knowledge transfer, and through the provision of advanced training in technology transfer and business incubation.

Expertise from Isis

Isis Enterprise consultants bring extensive experience of building innovation ecosystems and processes to enhance university-business interactions worldwide.

Working with the UoM Isis continues to assist with implementation of the knowledge transfer framework, working with local lecturers to deliver the study units that have been designed to transform science, technology, engineer ing and media graduates into successful knowledge-based entrepreneurs.

Isis Enterprise

Isis Enterprise (IE) was formed as a business group within Isis Innovation in 2004, to provide consulting expertise and advice in technology transfer and innovation management to clients worldwide. This year consultants and associate consultants worked in 24 different countries, and additional staff joined the IE team in the UK, Spain, China and Australia.

U n i v ersi t y of M a ltaL-Università ta’ Malta

9

Siberian technology

An International Commercialisation programme with the Tomsk Regional Administration in Russia, started in January 2011, has continued with further training programmes and brokered introductions to more than five European companies, leading to research agreements, product distribution and a licensing agreement.

Adoption of LEd Lighting

The development policy of the Malaysian Government is shifting more towards a high income and knowledge-based economy under its New Economic Model. In line with this, the government has set targets to assist local LED/SSL manufacturers to achieve world class standards. Together with The Eurasia Consortium Malaysia, Isis Enterprise has been supporting this initiative, working closely with SMECorp Malaysia to develop Malaysian LED Lighting manufacturers’ internationalisation strategies to address new global markets. Activities have included market landscape research, company audits, and strategic planning.

Sharing experience

Advising and supporting other universities’ technology transfer operations is an important part of Isis Enterprise’s business. In the UK assistance was provided to six universities, through IP identification and protection, project evaluation, technology commercialisation and licensing support. Clients can reduce their on-going patent maintenance costs from patent portfolio assessment exercises which highlight non-core IP to be dropped or out-licensed. A well-received software commercialisation course was held in Oxford and attended by representatives of universities and research centres across the UK.

Tomsk, located in the Siberian region of Russia

10

Software Commercialisation

Commercialisation of software is an important activity within Isis, and can take a number of forms such as traditional licensing of some of the world’s leading software packages, access to unique software tools and algorithms developed in Oxford, and the creation of ambitious new software-based ventures through the Software Incubator.

Incubating software companies towards investor readiness

An early participant in the Isis Software Incubator, colwiz (collective wizdom), demonstrates how Isis’ incubation processes help to create new business opportunities for entrepreneurs and investors. colwiz made great progress this year with the announcement of a development partnership and a strategic investment from the American Chemical Society, the world’s largest scientific society.

colwiz is a free research management, collaboration and productivity platform for individual researchers, groups, departments and organisations. Using web, desktop, and mobile applications synched in real time, the platform manages the entire research lifecycle from an initial idea, through complex collaboration, to publication of the results. The idea for colwiz was developed by leading researchers from the University of Oxford and transformed into a thriving new venture with users from industry and leading universities worldwide by its own founders with help from the Isis Software Incubator.

Adopted by industry leader

Trade and investment are undeniable proof of the commercial viability of new ideas and technologies and are the essential ingredients for business growth. In this case the American Chemical Society (ACS) investment has resulted in colwiz providing much of the underlying technology for ACS ChemWorx, which enables researchers to quickly create online profiles with comprehensive messaging and social communication features, to organise secure workgroups and

Isis Software Incubator Portfolio Venture Companies

Isis Software Incubator

The ISI has continued to attract exciting and innovative projects from undergraduates, researchers, staff and alumni of the University. At the end of the 2012-13 financial year 21 ventures had entered the incubator, of which a number are already fully fledged businesses, providing trade, employment and investment opportunities. Others are, with the support of the incubator, trading or engaging investors whilst continuing to develop their products and services. This demonstrates that the incubator is a great launchpad for establishing new businesses for the benefit of the individuals concerned and the wider economy.

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projects, share document libraries, manage calendars and group task lists, and to maintain private discussion areas. Integrated web, desktop, and mobile applications provide powerful capabilities for content discovery, reference and document management, coordinated storage and retrieval of data, and collaborative manuscript preparation and editing, as well as personal publication tracking with ACS Publications.

Every step of the research process - from forming an initial concept, to exchanging documents and literature references with a network of global collaborators, to assembling the resulting research findings with co-authors - can now be performed within the secure and interoperable ACS ChemWorx environment.

Professor David Gavaghan of Oxford University, colwiz Chief Scientist, commented, “colwiz shares ACS Publication’s vision of providing researchers with the tools they need to work together across continents and across disciplines, via software that manages the entire research lifecycle from an initial idea, through complex collaborations, and on to publication of the results.”

FMRI of the brain listening to sounds (blue) and seeing

pictures (orange)

Improving stroke treatment

Patients who suffer a stroke need urgent assessment of their brains’ computed tomography (CT) scan in order to receive optimum treatment. Specialist stroke experts worldwide use the Alberta Stroke Program Early CT Score (ASPECTS) pioneered by Alastair Buchan, Professor of Stroke Medicine and Head of the Medical Sciences Division at the University of Oxford to predict stroke outcomes and decide on treatment.

Brainomix, a start-up from the Isis Software Incubator, will put this specialist expertise in the hands of any doctor in an emergency department by automating the ASPECTS method, leading to better patient selection for stroke treatment and a higher chance of recovering the patient’s physical and mental function. Dr Michalis Papadakis, Managing Director and co-founder of Brainomix, said “The e-ASPECTS software we are developing encompasses both clinical and medical imaging innovation which we aim to translate into significant commercial and ultimately healthcare impact”.

The company co-founded by Professor Buchan,

l a u n c h e d a f t e r just six months in the Incubator, and

subsequently received an £820K development

grant f rom the Techno logy Strategy Board (TSB).

brain imaging analysis

Oxford’s multidisciplinary neuroimaging facility (FMRIB) brings together scientists and clinicians involved in all aspects of brain imaging research. Functional MRI provides new insight into memory formation, language, pain, learning and emotion, as well as being widely used to investigate conditions such as multiple sclerosis, stroke and Alzheimer’s. It is also helping us to better understand and manage these conditions, and to develop new treatments.

The FMRIB Software Library, available to license from Isis, has been downloaded over 10,000 times since its release in 2000, and has been commercially licensed to seven of the top 10 global pharmaceutical companies.

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Networks and Partnerships

International Technology Transfer

In Asia Isis is pioneering a networking and collaboration model called an international technology transfer centre (ITTC). Each centre requires some Isis staff, some investors with Oxford connections and one or more local partners such as a government agency, private investor or technology corporation. Through the recruitment of a team, and identifying the needs of the local economy, we create a networked platform for the introduction of new business opportunities based on ideas sourced from innovators and companies from all over the world, including Oxford.

The activities undertaken at each ITTC vary according to the local business sector priorities and local business competencies.

In Jiangsu Province (East China) our ITTC company is initially focused on biopharmaceuticals, medical devices, medical instruments and environmental technologies. When Isis identified a group of Ukrainian scientists with world leading heart monitoring technologies our ITTC secured investment from China. Together we are creating a new company to coordinate further development of the technology, establish manufacturing in China and manage clinical trials with carefully selected partners in Europe and China.

Meanwhile in Guangxi Province (West China) we are mainly focusing on projects relating to the regional strengths in automotive components, manufacturing, materials, tourism and agriculture. This joint venture is also establishing a 10,000m2 technology business

An important aspect of Isis’ role is to build networks and contacts with participants at all stages of the IP commercialisation value chain. We do this through long-standing networking groups run by Isis – the Oxford Innovation Society, and Isis Angels Network, working to maximise commercial and patient benefits by managing IP from the Oxford University Hospitals NHS Trust, and forming joint venture companies.

incubator facility (The Jinhui Technology Business Incubator, illustrated above) and an industrial product design platform. This incubator is due to open in November 2013 and will provide an ideal landing ground for companies looking to establish a base in one of China’s up and coming regions.

We are in discussions to create similar collaborations in Guangdong Province (South China), India and Malaysia.

Oxford Innovation Society

The OIS continues to be a pivotal network that bridges the gap between researchers and business people, building relationships that allow technologies to be commercialised and new companies formed. During the year members received more than 70 profiles of new technologies from Oxford, and attended events that showcased technologies such as organ preservation and computer games animation.

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IiIssu

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Also inside: Consultancy, training, new Oxford technologies and more

Isis insights

The latest innovations, collaborations and technology transfer

Understanding Parkinson’s disease

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Also inside: The Kennedy Trust, Expert Witness Consulting, MS Prognostic and more

Isis insights

The latest innovations, collaborations and technology transfer

DataConnecting and protecting

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1 S

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Isis insights

The latest innovations, collaborations and technology transfer

Scanning new horizonsImaging breakthroughs from Oxford

4 Software Commercialisation & Consultancy in the Social Sciences

22 Oxford catalysis 26 Tech Transfer in Mexico

6 WilmerHale 8 Microsoft 10 NaturalMotion 18 Portable diagnosis

5 OxSonics: Ultrasound-enhanced therapies

14 Non-toxic positron emission tomography

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Also inside: Proteomics, Dengue developments, Intellectual Property workshops

Isis insights

The latest innovations, collaborations and technology transfer

Sight for the blind

Subscribe to printed and online publications from the Isis website

@IsisInnovation

www.linkedin.com/company/ isis-innovation-ltd.

Raising awareness

The cycle of disclosures, patents and licenses is continuous, leading to a steady stream of new information to share with potential licensees, investors and others.

Regular events such as OIS meetings and IAN (Isis Angels Network) investor meetings provide attendees with the latest information, and we encourage frequent meetings with researchers and business contacts.

Isis’ quarterly magazine, Isis Insights, provides news of technologies and deals, and brochures designed for researchers, investors and industrial partners were produced during the year.

www.facebook.com/isisinnovation25 june 2013

with impact

saÏd business school

university of oxfordinnovation

www.isis-innovation.com

A range of ‘E-News’ publications distributed by email, and posts on LinkedIn, Twitter, Facebook and Weibo keep subscribers and followers up to date. These channels are growing in reach and importance.

We have updated our branding to visually reinforce Isis’ role as the technology commercialisation company of the University of Oxford.

Preparations for a Technology Showcase entitled “Innovation with Impact”, which were started this year, culminated in an inspiring event at the Saïd Business School.

e.weibo.com/u/3436649802

Communications

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Accounts 2013

Income & Expenditure 1

£0

£2,000,000

£4,000,000

£6,000,000

£8,000,000

£10,000,000

£12,000,000

£14,000,000

£16,000,000

Income Expenditure

Oxford Innovation Society, other

Payments to University & Researchers

Technology Transfer Project support

Administrative expenses

University subvention

Oxford University Consulting

Technology Transfer

Isis Enterprise

Income

Isis total income comes from sales turnover of £11.5m and the University subvention of £2.5m. Sales Turnover is made up of Technology Transfer licensing income, Oxford University Consulting income, Isis Enterprise consulting income, and OIS membership subscriptions. The University subvention to Isis of £2.5m per annum is used for investment into Oxford technology transfer project costs, the majority of which is invested in patenting inventions from researchers. Isis also receives an allocation of the University’s Higher Education Innovation Fund award to support Oxford University Consulting and the Isis Software Incubator. These amounts are shown in the accounts in ‘Other operating income’.

Spin-out company shareholdings

Shares in Oxford University spin-out companies set up by Isis are owned by the University of Oxford, not by Isis Innovation Ltd. They do not therefore appear in the Isis Innovation Ltd accounts either as assets on the balance sheet or showing income from realisations of shares or the payment of dividends from shares. The total value of the University’s shares in its spin-out companies at 31 July 2013 was £43m. Shares in start-up companies which are assisted by the Isis Software Incubator are owned by Isis Innovation Ltd; Isis owns minority shareholdings in these companies valued at a minimal cash cost.

Expenditure

The University subvention is invested in patents and other project costs incurred on Oxford technology transfer projects. Administrative expenses are the costs of running Isis which include our staff costs, marketing and office expenses. Isis distributes the net technology transfer licensing income and OUC income to the University and its researchers according to University rules. These outgoings are both included in ‘Cost of sales’ in the accounts. The loss this year is a result of increased investment in protecting University of Oxford intellectual property and in the growth of Isis Enterprise.

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Isis performance from 2000

Notes

1 A full set of accounts is available from Isis Innovation Ltd. Cost of sales for 2012 is adjusted to match 2013 classification of certain expenses from Administative expenses to Cost of Sales.

2 Isis distributes these sums to the University and individuals. The University in turn distributes these sums to individuals, Departments, and central accounts according to its standard procedures. This sum also includes the amount paid as gift aid by Isis to the University (2013: £0).

The directors are responsible for the maintenance and integrity of the corporate and financial information included in the company’s website. Legislation in the United Kingdom governing the preparation and dissemination of financial information differs from legislation in other jurisdictions.

£0

£1m

£2m

£3m

£4m

£5m

£6m

£7m

£8m

£9m

£10m

£11m

£12m

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013

Sales Income

Distributions& Covenant to University & Researchers2

Investment in Projects & Patents

University subvention

Profit & Loss Account1

Year to 31 March 2013 2012

£’000 £’000

Turnover £11,510 £10,201

Cost of Sales -£9,781 -£8,123

Gross Profit £1,729 £2,078

Administrative expenses -£5,044 -£4,968

Other operating income £3,070 £2,982

Operating profit / loss -£245 £92

Other interest receivable £6 £10

Profit on ordinary activities before gift aid and taxation

-£239 £102

Gift aid payable to University of Oxford £0 -£343

Profit / loss on ordinary activities after gift aid donation and before taxation

-£239 -£241

Taxation £0 £0

Profit / loss on ordinary activities after Gift Aid donation and after taxation

-£239 -£241

balance Sheet 1

Year to 31 March 2013 2012

£’000 £’000

Assets (fixed & current)

Tangible Assets £0 £18

Investments £42 £0

Debtors £2,623 £3,118

Cash at bank and in hand £1,318 £1,144

£3,983 £4,280

Creditors -£3,071 -£3,134

Net assets / liabilities £912 £1,147

Capital Funds

Share capital £1,750 £1,750

Profit & Loss account -£838 -£603

Shareholder funds £912 £1,147

Isis Innovation Ltd is wholly owned by the University of Oxford. Isis Innovation (Hong Kong) Ltd is a wholly owned subsidiary of Isis Innovation Ltd.

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Chairman Mr Bernard Taylor

managing director Mr Tom Hockaday

Non-Executive directors Professor Sir John Bell Regius Professor of Medicine, University of Oxford

Dr Tim Cook Non-Executive Director

Professor Steve Davies Professor of Chemistry, University of Oxford

Mrs Ann Hacker Non-Executive Director

Mr Nigel Keen Chairman, Oxford Instruments

Mr Giles Kerr Finance Director, University of Oxford

Professor Ewan McKendrick Registrar, University of Oxford

Professor Lionel Tarassenko

Professor Ian Walmsley

Director, Institute for Biomedical Engineering, University of Oxford

Pro-Vice-Chancellor (Research, Academic Services and University Collections)

Company Secretary Mr William Colquhoun University Finance Division

Auditors Deloitte LLP

Isis Innovation Ltd

Registered Address University Offices, Wellington Square, Oxford OX1 2JD

Address

Company Number 2199542

VAT Number 490798885

Isis Innovation Ltd

Ewert House, Ewert Place,

Summertown, Oxford OX2 7SG

T 01865 280830

F 01865 280831

E innovation@isis.ox.ac.uk

www.isis-innovation.com

Isis Innovation (Hong Kong) Ltd

Level 12, Infinitus Plaza,

199 Des Voeux Road Central,

Sheung Wan, Hong Kong SAR

T +852 3796 3581

E innovation@isis.ox.ac.uk

Isis Innovation Japan Office

ASTEM Building, Kyoto Research Park,

134 Minami-macho,

Chudoji-machi, Shimogyo-ku,

Kyoto 600-8813

T +81 75 315 8560

Isis Innovation Spain Office

Calle Orense 104C

Madrid 28020

Spain

T +34 630 816 286

Company details

17

Isis Innovation Ltd

Ewert House, Ewert Place,

Summertown, Oxford OX2 7SG

T 01865 280830

F 01865 280831

E innovation@isis.ox.ac.uk

www.isis-innovation.com

Isis Innovation (Hong Kong) Ltd

Level 12, Infinitus Plaza,

199 Des Voeux Road Central,

Sheung Wan, Hong Kong SAR

T +852 3796 3581

E innovation@isis.ox.ac.uk

Isis Innovation Japan Office

ASTEM Building, Kyoto Research Park,

134 Minami-macho,

Chudoji-machi, Shimogyo-ku,

Kyoto 600-8813

T +81 75 315 8560

Isis Innovation Spain Office

Calle Orense 104C

Madrid 28020

Spain

T +34 630 816 286

Design by Franks and Franks. Printed by Rumbold Holland to meet ISO 14001 standards, on Forest Stewardship Council (FSC®) accredited paper stock.

Isis staff photographed in summer 2013

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Isis Innovation LtdEwert House, Ewert Place, Summertown, Oxford OX2 7SGT +44 (0)1865 280830 F +44 (0)1865 280831 E innovation@isis.ox.ac.uk www.isis-innovation.com

Isis Innovation Ltd Annual Report 2013