INDEX [jpet.aspetjournals.org]jpet.aspetjournals.org/content/jpet/279/3/local/back-matter.pdf1996...
Transcript of INDEX [jpet.aspetjournals.org]jpet.aspetjournals.org/content/jpet/279/3/local/back-matter.pdf1996...
1590
INDEX
Volume 279, October-December, 1996
A2774 cells, effects ofendogenous TNF so-creted by, 84
Abai, A. M., see Beb#{246}k,Z., 1462Abdel-Rahman, A. A., see Mao, L., 443Abe, Y., Sekioka, K., Ishisu, R., Onishi, K.,
Ueda, Y. and Nakano, T.: Resto-ration ofischemic contractile fail-ure of indo-1-loaded guinea pigheart by a calcium sensitizer,MCI-154, 47
Abecarnil, tolerance and dependence lia-bility, in mice seizure models, 561
Abiko, Y., see Hara, A., 32Abrahams, T. P., Liu, W. and Varner, K.
J.: Blockade of alpha-2 adrener-gic receptors in the rostral ventro-lateral medulla attenuates the
sympathoinhibitory response tococaine, 967
Aceclidine, enantiomers, muscarimc re-
captor interactions, 1335Acetaminophen, toxicity
cholesteryl hemisuccinate protectionagainst, 1470
in male Wistar rats, 548Acetylcholine
-mediated vasodilation, inhibition by li-popolysaccharide, 918
release at neuromuscular junction, tet-randrine effects on, in mouse, 891
release in brain, enhancement bySA4503, in rat, 106
release in tracheal smooth muscle, ET-1effects on, in rat, 1142
Acetylcholine receptors
muscarinic
aceclidine enantiomer interactions,1335
allosteric lead structures for, 926Hml, Hm3 and Hm5, functional prop-
erties, 593-operated potassium currents, inhibi-
tion by amiodarone, 617mcotinic
agonist RJR-2403, in vitro character-ization, 1413
agonist RJR-2403, in vivo character-ization, 1422
hippocampal, mapping, 1491melatonin modulation of, in rat vas
deferens, 18N-(4-Acetyl-1-piperazinyl)-p-fluorobenz-
amidemonohydrate, see FK960AChRS, see Acetylcholine receptorsAcquired immunodeficiency syndrome,
ribavirin/ddl combination in, inmurine model, 1009
Adams, J. L., see Badger, A. M., 1453Adenosine deaminase, RBC-derived, 1250Adenosine receptors
A1, 8-butylaminoadenosine partial ago-msm at, 1439
A3, broncho8pasm induced by, in BDErats, 1148
Adenylyl cyclase
-mediated cell signaling, aging and, 478membrane-based activation assay for
beta-3 agonist potency, 214Adrenal gland, Egr-1 mRNA expression
in, neural control of, 379Adrenal medulla, catecholamine secretion
and ion channel inhibition by pro-tamine in, in bovine cells, 838
Adrenergic receptorsalpha-2
angiotensin receptor interactions, inrat nucleus reticularis gigantocel-lularis, 795
in ethanol-clonidine interactions, inrats, 443
rostral ventrolateral medullary block-ade, and cocaine sympathoinhibi-
tion, 967beta-3, agonist potency, receptor density
and, 214Adrenocorticotropic hormone, m-CPP and
DOl-induced secretion, 782w-Agatoxin-1VA, effects on motor nerve
Ca�� currents, in mouse, 1229Aging, and glucocorticoids, 478Agmatine, platelet I� binding sites, 694Agrawal, A� K. and Shapiro, B. H.: Im-
printed overinduction of hepaticCYP2B1 and 2B2 in adult ratsneonatally exposed to phenobar-bital, 991
Aguayo, L G., Tapia, J. C. and Pancetti, F.C.: Potentiation of the glycine-activated Cl current by ethanolin cultured mouse spinal neu-rons, 1116
AIDS, see Acquired immunodeficiencysyndrome
Airway musclecholinergic nerve-mediated contrac-
tions, ET-1 effects on, in rat, 1142non-neurogemc relaxation in, in canine,
813Aizeninan, E., see Boeckman, F. A., 515Akaike, T., see Noda, J., 162Akerman, E. 0., see Kukkonen, J. P., 593Albuquerque, E. X., see Alkondon, M.,
1491Albuquerque, E. X., see Marchioro, M., 143Alcohol, see EthanolAlendronate, comparison with raloxifene,
in rats, 298Ales, M. D., Wang, T., Giebisch, G., Sand-
ers, M. J., Walsh, A. H. andLopez-Anaya, A.: Model develop-ment and analysis of tenidap-induced proteinuria in the rat,1318
Alifio, S. F., see Blaya, C., 472Alkondon, M., Pereira, E. F. R. and Albu-
querque, E. X.: Mapping the loca-
tion of functional mcotinic andy-aminobutyric acidA receptorson hippocampal neurons, 1491
06-Alkylguanine DNA alkyltransferase,inactivation by triazene corn-pounds, 416
Allergic responseconjunctival itching, mediation by ke-
torolac, 137MDL 105,212 effects in, in guinea pig
model, 732Allosteric lead structures, 926�
rnethyl-1-piperazinyl)-3-hydroxy-benzyl]-N,N-diethylbenzarnide,see (±)-BW373U86
Alpert, N. M., see Christian, B. T., 325Alpert, N. M., see Fischrnan, A. J., 939American Society for Pharmacology and
Experimental Therapeutics (AS-PET), Colloquium Report, 1
�y-Arninobutyric acid, -gated chloride chan-nels, [3H]EBOB binding and in-secticide action on, 1191
-y-Aminobutyric acid receptors, agonist re-nal effects, in rat, 602
�y-Axninobutyric acidA receptorsin benzodiazepine-tolerant rats, 1092hippocampal, mapping, 1491insecticides and, in cerebellar granule
neurons, 1191stanozolol effects on, 186
(2R)-2-Amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyllpropi-onamide D-tartrate, see Re 22-9194
Arninoguanidine, pharmacokinetics andeffects on diabetes, in nonobesediabetic mice, 790
2-(2’-Amino-3’-rnethoxyphenyl)-oxanaph-thalen-4-one, see PD098059
N�-2-(4-Aminophenyl)ethyladenosine,bronchospasm induced by, inBDE rats, 1148
4-Arninopyridine, Kv4.2 blockade by, 865Arniodarone, effects on mAChR-operated
potassium currents, in guinea pigatrial cells, 617
Amrnonia, toxicity, trimethylarnine pre-ventive effects against, 194
Arnore, B. M., see Bennett, G. D., 1237Anabolic steroids, stanozolol
effects on GABAA receptor function, 186liver rnicrosorne binding site, in male
rat, 1123Analgesia, see also Antinociception
N-cyclobutylrnethyl analog of normor-phinone, 539
peripheral morphine, 502
Anderson, D. J., see Nigarn, R., 1527Anderson, D. J., see Simon, W. C., 1535Androgemc/anabolic steroids, stanozolol
effects on GABAA receptor function, 186liver microsome binding site, in male
rat, 1123Anesthesia, erythropoietin pharmacoki-
netics after, in sheep, 1205
1996 Index 1591
Angiotensin II receptors, atpha-2 adreno-ceptor interactions, 795
Angiotensin III receptors, atpha-2 adreno-ceptor interactions, 795
Angiotensin II, effects on cAMP release,114
Angiotensin I converting enzyme, single-domain, 1582
Angiotensin-converting enzyme, inhibitoreffects on bradykinin vasodepres-sor and prostacyclin responses,
703Anions, inorganic, and basolateral organic
cation transport system, in rabbitkidney proximal tubules, 1086
Antiarrhythmics, Re 22-9194, effects on
ventricular fibrillation, in dogs,877
Antibody, see atso Monoclonal antibodyantihuman anti-IgE, in monkeys, 1000-conjugated plasminogen activators,
pulmonary vasculature targeting,1026
Anticonvulsantsbenzodiazepine
effects, in direct cortical stimulationmodel, 803
receptor ligands, tolerance and depen-dence liability, 561, 573
L-701,324, proffle, 492
AntidepressantsBMS-181101, cerebral pharmacokinet-
ics, 325chronic, and 5-HT7 receptor activity, in
rat frontocortical astrocytes, 1551Antinociception, see aLso Analgesia
angiotensin-atpha-2 receptor interac-
tions in, in rat nucleus reticularisgigantocellularis, 795
f3-endorphin, pertussis toxin and, inmouse, 39
inhalation opioid, in mice, 69morphine
gender-related differences in, 767pertussis toxin and, in mouse, 39
spinal SNX-111, in rat neuropathicpain, 1243
sumatriptan, in rodents and guineapigs, 884
z�9-THC and morphine, dynorphins and,in spinal cord, 608
Antioxidantseffects on fibronectin turnover, in mes-
angial cells, 1520liver enzymes, cocaine-induced peroxi-
dative stress effects on, in rat,359
Aorta, glutathione S-transferases, glyc-eryl trinitrate biotransformationby, in rat, 1527
APNEA, see N�-2-(4-Aminophenyl)ethy-ladenosine
Apoptosisacetaminophen-induced, cholesteryl
hemisuccinate protection against,1470
induction by CoA-independent transacy-lase inhibitors, in HL-60 cells,956
lead-induced, in newborn rat, 435Aquino, A., see Prete, S. P., 1574Aracava, Y., see Marchioro, M., 143Arachidonic acid, effects on superoxide
generation in HL-60 cells, 633Archer, S., see Xu, J. Y., 539
Arends, R. H. G. P., see Hoogerkamp, A.,803
Argenzio, R. A., Armstrong, M. andRhoads, J. M.: Role of the entericnervous system in piglet crypto-sporidiosis, 1109
Armstrong, M., see Argenzio, R. A., 1109
Aromatic compounds, nitroso, pyruvatedehydrogenase complex-cata-lyzed formation of N-arylacetohy-droxamic acid from, in rat, 1282
Arrhythmiasischemia- and reperfusion-induced, Re
22-9194 effects on, in dogs, 877
proarrhythmic effects of fiecainide, 317related to delayed repolarization, 231
Arrington, S., see Bencherif, M., 1413Arthritis, antiarthritic effects of SB
203580 on, in animal models,1453
N-Arylacetohydroxamic acid, formation of,in rat, 1282
Asano, M., see Nomura, Y., 830ASPET, see American Society for Pharma-
cology and Experimental Thera-peutics
Asthma, IL-S suppression by T-440 in PB-MCs, 240
Astrocytes, chronic antidepressants and5-HT7 receptor activity in, in ratfrontal cortex, 1551
Atchison, W. D., see Xu, Y.-F., 1229Atkinson, M. A., see Bowman, M. A., 790Atochina, E. N., see Muzykantov, V. R.,
1026Atrial cells, mAChR-operated potassium
currents, inhibition by amioda-rone, in guinea pig, 617
AU1akh, C. S., see Mazzola-Pornietto, P.,782
Avenet, P., see Itier, V., 10923’-Azido-3’-dideoxythymidine, antiviral
effects, in murine cells, 1268AZT, see 3’-Azido-3’-dideoxythymidine
Babich, J. W., see Christian, B. T., 325Babich, J. W., see Fischman, A. J., 939Baclofen, renal effects, in rat, 602Baculovirus expression system, musca-
rinic ACh receptor subtypes ex-pressed in Sf� cells with, 593
Badger, A. M., Bradbeer, J. N., Votta, B.,Lee, J. C., Adams, J. L. and Gris-wold, D. E.: Pharmacological pro-file of SB 203580, a selective in-hibitor of cytokine suppressivebinding protein/p38 kinase, in an-imal models of arthritis, bone re-sorption, endotoxin shock and im-mune function, 1453
Baker, D. A., Khroyan, T. V., O’Dell, L. E.,Fuchs, R. A. and Neisewander, J.L.: Differential effects of intra-accumbens sulpiride on cocaine-induced locomotion and condi-tioned place preference, 392
Bakshi, V., see Swerdlow, N. R., 1290
Barnathan, B. S., see Muzykantov, V. R.,
1026Baron, B. M., Siegel, B. W., Harrison, B.
L., Gross, R. S., Hawes, C. andTowers, P.: [3HJMDL 105,519, ahigh-affinity radioligand for theN-Methyl-D-aspartate-associatedglycine recognition site, 62
Barone, F. C., Nelson, A. H., Ohlstein, E.H., Willette, R. N., Sealey, J. B.,Laragh, J. H., Campbell, W. G.,Jr. and Feuerstein, G. Z.: Chroniccarvedilol and propranolol re-duces mortality and renal dam-age in hypertensive stroke-pronerats, 948
Barrel field cortical neurons, cocaine sub-strates in, in rat, 582
Bartolini, A., see Ghelardim, C., 884
Bates, D. J., see Fox, J. A., 1000BDF,6153, platelet I� binding sites, 694Beanum, V. C., see Traylor, L. A., 91Beauchamp, D., see Harvie, P., 1009
Bebok, Z., Ansi, A. M., Dong, J.-Y., King,S. A., Kirk, K. L., Berta, G.,Hughes, B. W., Kraft, A. S., Bur-gess, S. W., Shaw, W., Felgner, P.L. and Sorscher, E. J.: Efficiencyof plasmid delivery and expres-sion after lipid-mediated genetransfer to human cells in vitro,1462
Bekavac, I., see Waterhouse, B. D., 582Bell, R. A., see Morita, K., 379Bernis, K., see Sato, M., 298Bencherif, M., see Lippiello, P. M., 1422Bencherif, M., Lovette, M. B., Fowler, K.
W., Arrington, S., Reeves, L.,Caldwell, W. S. and Lippiello, P.M.: RJR-2403: A nicotinic agonistwith CNS selectivity I. In vitrocharacterization, 1413
Bennett, B. M., see Nigam, R., 1527Bennett, B. M., see Simon, W. C., 1535Bennett, G. D., Amore, B. M., Finnell, R.
H., Wlodarczyk, B., Kaihorn, T.
F., Skiles, G. L., Nelson, S. D. andSlattery, J. T.: Teratogenicity ofcarbamazepine-10,1 1-epoxideand oxcarbazepine in the SWV
mouse, 1237Benyas, S., see Picker, M. J., 1130Benzodiazepines
anticonvulsant effects, in direct corticalstimulation model, 803
receptor ligands, in mice seizure models,561, 573
tolerance, GABAA receptors in, in rats,1092
1-(1,3-Benzodioxol-5-yl)-2-(methylami-no)butane, neuroendocrine phar-
macology, 1261
Bergeron, M. G., see Harvie, P., 1009
Bergman, M. R. and Holycross, B. J.:Pharmacological modulation ofmyocardial tumor necrosis factora production by phosphodiester-ase inhibitors, 247
Berta, G., see Bebok, Z., 1462Bertha, C. M., see Schetz, J. A., 1069Bevan, J. A., see Xie, H., 668Bicuculline, renal effects, in rat, 602
Bidlack, J. M., see Xu, J. Y., 539Bigelow, G. E., see Walsh, S. L., 524Biliary function, TP-680 effects on, 1404Biotransformation, see also Metabolism
diltiazem, P450 inhibition during, in ratliver, 1447
glyceryl trimtrate, by rat aortic GSTs,1527
Bladder, urinary, tachykinin NK-2 recep-tore in, in dog, 423
Blaney, B., see Higashiura, K., 1386
1592 index Vol. 279
Blaya, C., Crespo, J., Crespo, A. and Alino,S. F.: Anti-interleukin 4 antibodyand indomethacin synergistic ef-fect on B16 melanoma tumor pro-
gression, 472Blink rate, dopamine agonist effects on, in
cynomolgus monkeys, 1211
Blood, see also Peripheral blooddynorphin A (1-17) biotransformation,
human and rhesus monkey, 507Blood pressure, bradykinin response, ACE
inhibitor effects on, 703Blood-brain barrier, peptide drug delivery,
CNS effects, in rats, 77Blower, P. R., see Gr#{233}lot, L., 255
BMS-181101, cerebral pharmacokinetics,325
Boada, L. D., Fern#{225}ndez, L., Zumbado, M.,Luzardo, 0. P., Chirino, R. andDfaz-Chico, B. N.: Identificationof a specific binding site for theanabolic steroid stanozolol inmale rat liver microsomes, 1123
Boeckman, F. A. and Aizenman;E.: Phar-macological properties of ac-quired excitotoxicity in Chinese
hamster ovary cells transfected
with N-methyl-D-aspartate recep-
tor subunits, 515Bomers, A. M., see Hoogerkamp, A., 803Bonab, A. A., see Fischman, A. J., 939Bone resorption, antiarthritic effects of SB
203580 on, in animal models,1453
Bonmassar, B., see Lacal, P. M., 416Bonmassar, E., see Prete, S. P., 1574Bosche, M. C., see Nandi, J., 97Bosron, W. F., see Kamendulis, L. M., 713Boulanger, C. M., see Desta, B., 1077Bowersox, S. S., Gadbois, T., Singh, T.,
Pettus, M., Wang, Y.-X. andLuther, R. R.: Selective N-typeneuronal voltage-sensitive cal-cium channel blocker, SNX-111,produces spinal antinociceptionin rat models of acute, persistentand neuropathic pain, 1243
Bowman, M. k, Simell, 0. G., Peck, A. B.,Cornelius, J., Luchetta, R., Look,z., Maclaren, N. K. and Atkinson,M. A.: Pharmacokinetics of ami-noguanidine administration andeffects on the diabetes frequency
in nonobese diabetic mice, 790
Boyd, M. R., see Currens, M. J., 645
Boyd, M. R., see Currens, M. J., 652Boyd, M. R., see Vistica, D. T., 1018Boyle, F. M., Wheeler, H. R. and Shenfield,
G. M.: Glutamate ameliorates ex-perimental vincristine neuropa-thy, 410
Bradbeer, J. N., see Badger, A. M., 1453
Bradykinin, vasodepressor and prostacy-cm responses, ACE inhibitor ef-fects on, 703
Brain
acetyicholine release in, enhancementby SA4503, in rat, 106
CRF and CRF-R1 mRNA levels afterbinge cocaine administration, inrat, 351
dopamine neurons, NMDA currents in,in rat, 457
5-hydroxytryptamine release in, effectsofrepeated MDMA on, in rat, 277
Brain tumors, cytotoxins selective for,1018
Brauneis, U., Oz, M., Peoples, R. W.,Weight, F. F. and Zhang, L.: Dif.ferential sensitivity of recombi-nant N-methyl-D-aspartate recep-tor subunits to inhibition bydynorphin, 1063
Breimer, D. D., see Math#{244}t,R. A. A., 1439
Brenic, S., see Mayer, A. M. S., 633Bristow, L. J., Hutson, P. H., Kulagowski,
J. J., Leeson, P. D., Matheson, S.,Murray, F., Rathbone, D., Say-well, K. L, Thorn, L., Watt, A. P.and Tricklebank, M. D.: Anticon-vulsant and behavioral proffle ofL-701,324, a potent, orally activeantagonist at the glycine modula-tory site on the N-methyl-D-as-partate receptor complex, 492
Brixius, K., see Mtlller-Ehmsen, J., 1220BRL 37344, potency, receptor density and,
214N-[2-(p-Bromocinnamoylamino)ethyl]-5-
isoquinoline-sulfonamide, effects
on parietal cell function, in rab-bit, 97
Bronchiolar cytotoxicity, 1,1-dichloroeth-ylene, in adult and weanlingmice, 1484
Bronchospasm, APNEA-induced, in BDErats, 1148
Brown, N. J., Ryder, D., Gainer, J. V., Mor-row, J. D. and Nadeau, J.: Differ-ential effects of angiotensin con-verting enzyme inhibitors on thevasodepressor and prostacyclinresponses to bradykinin, 703
Browne, M. J., see Wilson, S., 214Brownfield, M. S., see Li, Q., 1261Bryant, H. U., see Sate, M., 298Brzezinski, M. R., see Kamendulis, L. M.,
713Buckheit, R. W., Jr., see Currena, M. J.,
645Buflini, J. D., see Fox, A. W., 686Burcher, E., see Mussap, C. J., 423
Burgess, S. W., see Bebok, Z., 1462Burgmer, U., see Trankle, C., 926Burka, L. T., see Nomeir, A. A., 222Burke, see Zerrng, G., 23Burkhoff, D., see TOdaka, K., 120Burkholder, T. P., see Kudlacz, E. M., 732Burr, D. B., see Sate, M., 298Butelman, E. R., see Yu, J., 507Butelman, E. R., Lewis, J. W. and Woods,
J. H.: Methoclocinnamox: Agonist
and antagonist effects of a novellong-lasting opioid in rhesus mon-keys, 934
Butler, A. M., see Murray, M., 1447Butorphanol, discriminative stimulus ef-
fects of, 1130Butschky, M. F., see Pickworth, W. B., 4508-Butylaminoadenosine, partial agonism
at A1 receptor, 1439(±)-4-(3-t-Butylamino-2-hydroxypropoxy-
)benzimidazol-2-one, see CGP12177
[355] t-Butylbicyclophosphorothionate,GABA-stimulated binding, stano-
zolol effects on, 186(±)-BW373U86, methylether derivative,
metabolism of, 1069
Caine, G., see Lefebvre, M., 902
Calanolide AHIV inhibition by, 645HW reverse transcriptase inhibition by,
652Calcium
buffering by sarcoplasmic reticulum, inrat femoral arterial smooth mus-cle, 830
-dependent potassium channels, activa-tion, NO-synthase expressionand, 1514
effects in torsades de pointes, 231Calcium channels
L-type, cGMP effects on, in guinea pigventricular myocytes, 1274
motor nerve, w-agatoxin-IVA andw-conotoxin-MVIIC effects on, inmouse, 1229
voltage-sensitive, N-type, and spinal an-tinociception in rat neuropathicpain, 1243
Calcium sensitizerslevosimendan, effects on myocardial
contractility and oxygen con-sumption, 120
MCI-154, effects on ischemic dysfunc-tion, in guinea pig heart, 47
Calderon, S. N., see Schetz, J. A., 1069Caldwell, W. S., see Bencherif, M., 1413Calphostin-C, effects on parietal cell func-
tion, in rabbit, 97cAMP, see Cyclic adenosine monophos-
phateCampbell, W. G., Jr., see Barone, F. C., 948Cancer
CEA expression in, effects of 5-fiuorou-
racil on, 1574ovarian, effects of endogenous TNF in,
84Carbamazepine-10,11-epoxide, teratoge-
nicity, in SWV mouse, 1237Carbon dioxide, inhalation, inhibitory ef-
fects on pulmonary stretch recep-tors, in rabbit, 402
Carboxylesterase-mediated heroin metab-olism, 713
(R)-1-3-[3-(3-Carboxypyridine-2-yl)thio-2-(indol-2-yl)carbonylaminolpropio-nyl-4-diphenyl-methyl-pipera-zine, see TP-680
Carcillo, J. A., Herzer, W. A., Mi, Z.,Thomas, N. J. and Jackson, E. K.:Treatment with the type IV phos-phodiesterase inhibitor Ro 20-1724 protects renal and mesen-teric blood flow in endotoxemicrats treated with norepinephrine,1197
Carcillo, J. A., Jr., see Jackson, E. K., 1250
Carcinoembryonic antigen, expression, ef-fects of 5-fluorouracil on, in can-cer cells,1574
Cardiac hypertrophy, diuretic effects on,in spontaneously hypertensiverats, 983
Cardiac sympathetic ganglia, inhibition bydopamine receptors, in canine,
822Cardiovascular system
regulation of, angiotensin-atpha-2 re-
ceptor interactions in, 795thrombin receptor activation in vivo
and, 1365Caisson, L., Drews, L. and Duker, G.:
Rhythm anomalies related to de-
1996 Index 1593
layed repolarization in vivo. In-fluence of sarcolemmal Ca� � en-try and intracellular Ca�overload, 231
Carneiro, R. C. G., see Markus, R. P., 18Carnitine, derivatives containing trimeth-
ylamine, preventive effectsagainst ammonia toxicity andglutamate neurotoxicity, 194
Carroll, F. I., see Fleckenstein, A. B., 200Carvedilol, effects on survival in stroke-
prone spontaneously hyperten-sive rats, 948
Casida, J. E., see Huang, J., 1191Catalepsy, cholinergic neurons and, in
mouse striatum, 1430Catecholamine, secretion, inhibition by
protamine, in bovine adrenalmedullary cells, 838
Cathinone, N-methylated analog enanti-
omer effects, 1043Cations, organic, basolateral transport
system, in rabbit kidney proximaltubules, 1086
Cell death, see ApoptosisCell signaling, mediated through adenylyl
cyclase, aging and, 478Central nervous system
effects of peptide drug delivery to blood-brain barrier on, in rats, 77
-selective agonist RJR-2403
in vitro characterization, 1413in vivo characterization, 1422
CerebellumGABA-gated chloride channels in,
[3H]EBOB binding and insecti-cide action on, in granule neu-rons, 1191
lead neurotoxicity and apoptotic effectsin, in newborn rat, 435
Cerebrum
BMS-181101 pharmacokinetics, byPET, 325
thiopental kinetics, enantiomeric analy-sis in sheep, 291
CGMP, see Cyclic guanosine monophos-phate
CGP 12177, potency, receptor density and,214
Chabot-Fletcher, M., see Winkler, J. D.,956
Chait, B. T., see Yu, J., 507Chambers, J. K., see Wilson, S., 214Chan, A. W. K., see Devi, B. G., 359Chan, B. S. H., Lazzaro, V. A., Scale, J. P.
and Duggin, G. G.: Transport ofparaquat in a renal epithelial cellline LLC-PK1, 625
Chan, S. H. H., see Yang, C.-H., 795Chapman, C. G., see Wilson, S., 214Cheung, W.-M., see Damiano, B. P., 1365Chiba, K., see Kim, R. B., 4Chiba, K., see Thao, X.-J., 1327Chikkala, D. N., see Piletz, J. E., 694Chilton, F. H., see Winkler, J. D., 956Chinese hamster ovary cells, NMDA re-
ceptor subunit-transfected, ac-quired excitotoxicity in, 515
Chirino, R., see Boada, L. D., 112336Chloride, GABA-stimulated influx,
stanozolol effects on, 186Chloride channels
endothelin receptor coupling, in rat pul-monary arterial myocytes, 1053
GABA-gated, [3HIEBOB binding and in-secticide action on, in cerebellargranule neurons, 1191
glycine-activated, potentiation by etha-nol, in mouse spinal neurons,1116
7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)quinolone, see L-701,324
(RR,SS)-(±)-4-[(2-(2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-propyl]phe-
noxyacetate, see BRL 373443�-(3-p-Chlorophenyl)tropan-2�3-carbox-
ylic acid p-isothiocyanatophenyl-ethyl ester hydrochloride, seeRTI-76
Chlorzoxazone, oral, disposition in Japa-nese and Caucasians, 4
CHO, see Chinese hamster ovary cellsCholecystokinin, mechanisms of action, in
canine GI tract, 306
Cholecystokinin receptors, antagonist TP-680, pharmacological profile,1404
Cholesteryl hemisuccinate, protectionagainst acetaminophen hepato-toxicity, 1470
Cholinederivatives containing trimethylamine,
preventive effects against ammo-nia toxicity and glutamate neuro-toxicity, 194
hepatic uptake, in rat, 774Cholinergic system
airway, ET-1 effects on, in rat trachealsmooth muscle, 1142
effects in sumatriptan antinociception,in rodents and guinea pigs, 884
neurons, and catalepsy, in mouse stria-turn, 1430
Christian, B. T., Livni, B., Babich, J. W.,Alpert, N. M., Dischino, D. D.,Ruediger, E., Salazar, D. E., Ford,
N. F. and Fischman, A. J.: Evalu-ation of cerebral pharmacokinet-ics of the novel antidepressantdrug, BMS-181101, by positronemission tomography, 325
Chu, Y., see Taguchi, H., 1514
Cicero, T. J.: Gender-related differences inthe antinociceptive properties ofmorphine, 767
Cipris, S., see Vergara, P., 306Cisplatin-induced emesis, delayed by
granisetron, in piglet, 255Claes, C., see De Ryck, M., 748
Clerico, L., see Debernardis, D., 84Clincke, G., see De Ryck, M., 748Clobazam
anticonvulsant effects, in direct corticalstimulation model, 803
tolerance and dependence liability, inmice seizure models, 561
Cloccinamox, opioid receptor blockade, 23Clonazepam
anticonvulsant effects, in direct corticalstimulation model, 803
tolerance and dependence liability, inmice seizure models, 561
Clonidine, ethanol interactions, in rats,443
Cocainebinge administration, CRF and CRF-R1
mRNA levels after, in rat brainand pituitary, 351
chronic withdrawal, CRF and CRF-R1mENA levels during, in rat brainand pituitary, 351
conditioned place preference induced by,intra-accumbens sulpiride and,177
esterase-mediated metabolism, 713
immunotoxicity, in B6C3F1 and DBAJ2mice, 3
liver toxicity, in rat, 359locomotive effects, intra-accumbens
sulpiride and, 177opioid interactions, 524plasma concentrations, arterial and ye-
nous, 1345
substrates, in rat barrel field corticalneurons, 582
sympathoinhibitory responses, blockadeby rostral ventrolateral medul-lary alpha-2 receptor, 967
Codeine, inhalation exposure, antinocicep-tire effects, in mice, 69
Coenzyme A-independent transacylase in-hibitors, apoptosis induction by,in HL-60 cells, 956
Cognition, enhancement by FK960, inrats, 1157
Coirault, C., see Joseph, T., 464Coffins, A. C., see Lippiello, P. M., 1422Collins, K. A., see Tseng, L. F., 39Colon carcinoma, CEA expression in, ef-
fects of 5-fluorouracil on, 1574Compounds, dermal application, local
deep tissue penetration of, 908
Conditioned place preferencecocaine-induced, intra-accumbens
sulpiride and, 392morphine-induced, TAN-67 effects on, in
mice, 177Cone, E. J., see Evans, S. M., 1345Conjunctival pruritus, ketorolac effects
against, 137w-Conotoxin-MVIIC, effects on motor
nerve Ca� � currents, in mouse,1229
ContractionscGMP effects on, in guinea pig ventric-
ular myocytes, 1274cholinergic nerve-mediated, ET-1 effects
on, in rat tracheal smooth muscle,1142
flow-induced, PKC effects in, 668
giant migrating, PAP-induced, duringileal inflammation, 207
myocardial, levosimendan effects on,120
Cornelius, J., see Bowman, M. A., 790Coronary artery
effects of dexfenfluramine on, porcine,1077
vasodilatory actions of mcorandil on, in
human tissue, 1220Corpus striatum
cholinergic neurons, organization, inmouse, 1430
dopamine transporter, inactivation byRTI-76, 200
GDNF functional effects in, in rat, 1181histamine release in, effects ofacute and
chronic methamphetamine on, inrat, 271
Corradetti, R., see Pugliese, A. M., 1100
Cortex
1594 Index VoL 279
chronic antidepressants and 5-HT7 re-ceptor activity in, in rat astro-cytes, 1551
cocaine substrates in, in rat, 582Corticotropin-releasing factor, mRNA 1ev-
els after binge cocaine adminis-tration, 351
Corticotropin-releasing factor receptors,type 1, mRNA levels after bingecocaine administration, 351
Crankshaw, D. J., see Senchyna, M., 262Crespo, A., see Blaya, C., 472Crespo, J., see Blaya, C., 472CRF, see Corticotropin-releasing factorCromakalim, mechano-energetic effects on
left ventricular papillary muscle,in guinea pig, 464
Cronk, D. W., see Wilson, S., 214Cryptosporidiosis, enteric nervous system
in, in piglet, 1109Currens, M. J., Gulakowski, R. J., Marl-
ncr, J. M., Moran, R. A., Buck-heit, R. W., Jr., Gustafson, K. R.,McMahon, J. B. and Boyd, M. R.:Antiviral activity and mechanismof action of calanolide A against
the human immunodeficiency vi-rus, 645
Currens, M. J., Mariner, J. M., McMahon,J. B. and Boyd, M. R.: Kineticanalysis of inhibition of humanimmunodeficiency virus reversetranscriptase by calanolide A, 652
Cu,Zn-superoxide dismutase, succinylatedkeratin fragment conjugate, ef-fects, 162
Cyclic adenosine monophosphateaccumulation, 5-HT7 receptor-mediated,
chronic antidepressants and, inrat, 1551
accumulation assay for beta-3 agonist
potency, 214release in kidney, angiotensin II effects
on, in spontaneously hyperten-sive rat, 114
Cyclic guanosine monophosphate, effectson L-type calcium current andcontractions, in guinea pig yen-tricular myocytes, 1274
N-Cyclobutylmethyl, normorphinone ana-log binding and analgesia, 539
3-(3-Cyclopropyl-5-isoxazolyl)-6-fluoro-5-morpholino-imidazo[1,5-a]quina-
zoline, see NNC 14-0185
3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-7-fluoro-5-(4-methyl-1-piperazinyl)-
imidazol[1 ,5-a]quinazoline, seeNNC 14-0189
Cyclo[-D-a-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonyl1-L-alanyl-i�-a-aspar-tyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl]disodium salt, seeTAK-044
Cytochrome P4502B1, imprinted overinduction of, in
adult rats neonatally exposed tophenobarbital, 991
2B2, imprinted overinduction of, inadult rats neonatally exposed tophenobarbital, 991
2C19, quinine 3-hydroxylation by, inliver microsomes, 1327
2D, impipramine-induced inactivationof, in rat liver microsomes, 724
2E1, activity in Japanese and Cauca-sians, 4
3A2, inhibition during diltiazem bio-transformation, in rat liver, 1447
3A4, quinine 3-hydroxylation by, in livermicrosomes, 1327
human recombinant, quinine 3-hy-droxylation by, in liver micro-somes, 1327
Cytokine receptors, soluble, as carrier pro-teins, 340
Cytokine suppressive binding protein, in-hibitor SB 203580, pharmacolog-ical proffle, in animal models,1453
Cytotoxicitybronchiolar, 1,1-dichloroethylene, in
adult and weanling mice, 1484
indomethacin, leminoprazole protection
against, in rabbit gastric mucosalcells, 975
lipid A, nitric oxide effects in, 91Cytotoxins, brain tumor-selective, 1018
Daggett, L. P., see Varney, M. A., 367DaM, S. G., see SOUIard, C. D., 1379Dams, K., Hitzemann, B. and Hitzemann,
R.: Genetics, neuroleptic responseand the organization of cholin-ergic neurons in the mouse stria-turn, 1430
Dal Cason, T. A., see Sparago, M., 1043Damiano, B. P., Cheung, W.-M., Mitchell,
J. A. and Falotico, R.: Cardiovas-cular actions ofthrombin receptoractivation in vivo, 1365
Dan, K., see Mukai, M., 822Danhof, M., see Hoogerkamp, A., 803Danhof, M., see Math#{244}t,R. A. A., 1439Daniel, B. B., see Vergara, P., 306Danilov, S. M., see Muzykantov, V. R.,
1026D’Atri, S., see Local, P. M., 416ddl, see 2’,3’-DideoxyinosineDc Filippi, R., see Prete, S. P., 1574De Ryck, M., Keersmaekers, R.,
Duytschaever, H., Claes, C.,Clincke, G., Janssen, M. and VanReet, G.: Lubeluzole protects son-
sorimotor function and reduces
infarct size in a photochemicalstroke model in rats, 748
Dc Santis, S., see Prete, S. P., 1574De Vecchis, L., see Prete, S. P., 1574Deal, C., see Varney, M. A., 367Dean, R. A., see Kamendulis, L. M., 713Debernardis, D., Stanzione, S., Ottobom,
C., Clerico, L., Mancuso, T.,Parodi, S. and Russo, P.: Endoge-nous tumor necrosis factor en-hances topoisomerase II inhibi-tors activity in human ovariancancer cell lines, 84
Deddish, P. A., Wang, L.-X., Jackman, H.L., Michel, B., Wang, J., Skidgel,R. A. and ErdOs, E. G.: Single-domain angiotensin I convertingenzyme (kininase II): Character-ization and properties, 1582
Deitrich, R. A., see Erwin, V. G., 1310Delyani, J. A., Nossuli, T. 0., Scalia, R.,
Thomas, G., Garvey, D. S. andLefer, A. M.: S-Nitrosylated tis-sue-type plasminogen activatorprotects against myocardial iseh-
emia/reperfusion injury in cats:Role of the endothelium, 1174
Dependencebenzodiazepine receptor ligand liability,
in mice, 561, 573
ethanol, ganglioside effects against, 128morphine, substance P(1-7) effects on,
662reverse use, ofKv4.2 blockade by 4-ami-
nopyridine, 865Depoortere, H., see Itier, V., 1092L-Deprenyl, effects on excitatory synaptic
transmission, in rat hippocam-pus, 740
Dermal application of compounds, localdeep tissue penetration, 908
D#{233}sormeaux, A., see Harvie, P., 1009
Desta, B., Schultz, D., Ravel, D., Lau-dignon, N., Vanhoutte, P. M. andBoulanger, C. M.: Acute andchronic effects of dexfenfluramine
on the porcine coronary artery,1077
Devi, B. G. and Chan, A. W. K.: Cocaine-induced peroxidative stress in ratliver: Antioxidant enzymes andmitochondria, 359
Dexfenfluramine, acute and chronic ef-fects on coronary artery, porcine,1077
Diabetes, aminoguanidine effects on, innonobese diabetic mice, 790
Dfaz-Chico, B. N., see Boada, L. D., 1123Diazepam
anticonvulsant effects, in direct corticalstimulation model, 803
dependence liability, in mice seizuremodels, 561
toleranceGABAA receptors in, in rats, 1092liability, in mice seizure models, 561
Dicarboxylate, carrier, fluorescein interac-
tions, in rat kidney cortex mito-chondria, 1559
1,1-Dichioroethylene, metabolism, inadult and weanling mice, 1484
2’,3’-Dideoxyinosine, combined with riba-vim, in murine AIDS model,1009
Dilazep, effects on PALCAR-induced me-
chanical derangement, in ratheart, 32
Diltiazem, metabolismorgan-specific, in rabbits, 902P450 inhibition during, in rat liver, 1447
1-(2,5-Dimethoxy-4-iodophenyl)-2-amin-opropane, neuroendocrine effects,tolerance, 782
1-(3,4-Dimethoxyphenethyl)-4-(3-phenyl-propyl)piperazine dihydrochlo-ride, see SA4503
Dischino, D. D., see Christian, B. T., 325l4cr,14’f3-[Dithiobis[(2-oxo-2,1-ethanediy-
l)imino]]bis[7,8-dihydro-N-(cy-clobutylmethyl)-normorphinone],binding and analgesia, 539
Diuresis, effects of fedotozine vs other �c
agonists on, in rats, 1379Diuretics, effects on cardiac hypertrophy,
in spontaneously hypertensiverats, 983
DOl, see 1-(2,5-Dimethoxy4-iodophenyl)-2-aminopropane
Dombrowski, D. S., see Pugh, G., Jr., 608Dong, J.-Y., see Bebok, Z., 1462
1996 Index 1595
DopamineGDNF functional effects on, in rat stri-
atum, 1181neuron NMDA currents, in rat brain,
457transporter inactivation by intrastriatal
RTI-76, 200Dopamine receptors
agonist effects on eye blink rate, in cyno-molgus monkeys, 1211
antagonist effects on METH-inducedhistamine release, in rat stria-turn, 271
D4 antagonist U-101387, pharmacologi-cal characterization, 1392
ganglionic inhibition by, in canine car-diac sympathetic ganglia, 822
Dowsley, T. F., see Forkert, P. G., 1484Drews, L., see Carlsson, L., 231Drug delivery
peptide blood-brain barrier, CNS ef-fects, in rats, 77
solute structure and penetration, 908Drug discrimination, butorphanol, 1130Drug interactions, fluorescein, in rat kid-
ney cortex mitochondria, 1559Du Souich, P., see Lefebvre, M., 902Duckles, S. P., Krause, D. N. and Miller, V.
M.: Effects of gonadal steroids onvascular function, 1
Ducros, L., see Joseph, T., 464Duggin, G. G., see Chan, B. S. H., 625Duker, G., see Carlsson, L., 231Dusserre, N., see Harvie, P., 1009
Dutton, P. L., see Johansson, J. S., 56Duytschaever, H., see De Ryck, M., 748Dynorphin
NMDA receptor sensitivity, 1063and i�#{176}-THCcombined with morphine,
in spinal cord, 608Dynorphin A (1-17), biotransformation,
human and rhesus monkey blood,507
Eaton, M. J., see Merchant, K. M., 1392Ebert, U., see Loscher, W., 561Ebert, U., see Loscher, W., 573[3H]EBOB, see [3H]Ethynylbicycloortho-
benzoateEckhardt, U., see Kontaxi, M., 1507Egr-1, neural control of, in rat adrenal
gland, 379Ehlert, F. J., Griffin, M. T. and Glidden,
P.: The interaction of the enanti-omers of aceclidine with subtypesof the muscariic receptor, 1335
Elfas, M. M., see Monasterolo, L. A., 602Elfas, M. M., see Trumper, L., 548Ellipticines, quaternized, accumulation by
human tumor cells, 1018Elmaleh, D. R., see Fischman, A. J., 939Emesis, delayed, by repeated granisetron,
in piglet, 255Endoh, T., see Suzuki, T., 177
13-Endorphin, antinociceptive effects, per-tussis toxin and, in mouse, 39
Endothelin-1effects on airway cholinergic nerves, in
rat, 1142electrophysiological effects, in rat pul-
monary arterial myocytes, 1053Endothelin receptors, potassium and chlo-
ride channel coupling, in rat pul-monary arterial myocytes, 1053
EndothelinA receptor, antagonism byTA.K-044, 675
Endothelin5 receptor, antagonism byTAK-044, 675
Endotoxemia, norepinephnne combinedwith Re 20-1724 treatment, inrat, 1197
Endotoxin shock, antiarthritic effects ofSB 203580 on, in animal models,1453
Ensinger, H. A., see Meade, C. J., 1148
Enteric nervous system, in cryptosporidi-osis, in piglet, 1109
Enterocyte microsomes, riuabutin disposi-tion and metabolism by, in rats,1300
Erd#{246}s,E. G., see Deddish, P. A., 1582Ens, T., see Winkler, J. D., 956Erwin, V. G. and Deitrich, R. A.: Genetic
selection and characterization of
mouse lines for acute functionaltolerance to ethanol, 1310
Erythrocytes, injured, adenosine deami-nase release by, 1250
Erythropoietin, pharmacokinetics, insheep, 1205
Esterase-mediated heroin metabolism,713
Estrogen, comparison with raloxifene, inrats, 298
ET, see EndothelinEthanol
clonidine interactions, in rats, 443dependence, ganglioside effects against,
128glycine receptor potentiation by, in
mouse spinal neurons, 1116tolerance, genetic selection for, in mouse
lines, 1310[3H]Ethynylbicycboorthobenzoate, binding
on GABA-gated chloride channel,in cerebellar granule neurons,1191
ET-18-O-CH3, see 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocho-line
Evans, H. L., see Oberto, A., 435Evans, S. M., Cone, E. J. and Henning-
field, J. E.: Arterial and venouscocaine plasma concentrations inhumans: Relationship to route ofadministration, cardiovasculareffects and subjective effects,1345
Excitation, decrease by felbamate, in CAlrat hippocampal slices, 1100
Excitatory synaptic transmission, L-depre-nyl effects on, in rat hippocam-pus, 740
Excitotoxicity, acquired, in NMDA recep-tor subunit-transfected CHOcells, 515
Eye blink rate, dopamine agonist effectson, in cynomolgus monkeys, 1211
Falotico, R., see Damiano, B. P., 1365Fant, R. V., see Pickworth, W. B., 450Faraci, F. M., see Taguchi, H., 1514Fariss, M. W., see Ray, S. D., 1470Fedotozine, effects on diuresis, in rats,
1379Felbamate, excitation decrease by, in CAl
rat hippocampal slices, 1100Felgner, P. L., see Bebok, Z., 1462Felipo, V., see Mi#{241}na, M.-D., 194Female-dominant sulfotransferases, on-
togeny and hormonal basis, in ratliver, 386
Femoral arterial smooth muscle, sarco-plasmic reticulum calcium buffer-ing action in, in rat, 830
Fentanyl, inhalation exposure, antinoci-ceptive effects, in mice, 69
Fernandes, L. B., see Knott, P. G., 1142Fern#{225}ndez,L., see Boada, L. D., 1123Fernandez-Botran, R., see Ma, V., 340Ferrier, G. R., 317Feuerstein, G. Z., see Barone, F. C., 948Fibrinolytics, lung targeting, 1026Fibronectin, turnover, silibinin effects on,
in mesangial cells, 1520Figini, M., see Ghelardini, C., 884Finnell, R. H., see Bennett, G. D., 1237Fischman, A. J., see Christian, B. T., 325Fischman, A. J., Bonab, A. A., Babich, J.
W., Alpert, N. M., Rauch, S. L.,Elmaleh, D. R., Shoup, T. M., Wil-hams, S. A. and Rubin, R. H.:Positron emission tomographicanalysis ofcentral 5-hydroxytryp-tamine2 receptor occupancy inhealthy volunteers treated withthe novel antipsychotic agent, zi-prasidone, 939
Fisher, A. B., see Muzykantov, V. R., 1026FK960, cognitive enhancement by, in rats,
1157Flecainide, proarrhythmic effects, 317Fleckenstein, A. E., Pogun, S., Carroll, F.
I. and Kuhar, M. J.: Recovery ofdopamine transporter bindingand function after intrastriataladministration of the irreversibleinhibitor RTI-76 {3�3-(3-p-chloro-phenyl)tropan-213-carboxylic acidp-isothiocyanatophenylethyl es-ter hydrochloride), 200
Flow-induced contraction, PKC effects in,
668
Flunitrazepam, anticonvulsant effects, indirect cortical stimulation model,803
Fluorescein, dicarboxylate carrier interac-tions, in rat kidney cortex mite-
chondria, 15594-(4-Fluorophenyl)-2-(4-methylsulfinyl-
phenyl)-5-(4-pyridyl)imidazole,see SB 203580
5-Fluorouracil, effects on CEA expression,in cancer cells, 1574
Fluoxetine, chronic, desensitization of
5�1A receptors by, 1035Ford, N. F., see Christian, B. T., 325Forkert, P. G., Dowsley, T. F., Lee, R. P.,
Hong, J.-Y. and Ulreich, J. B.:Differential formation of 1,1-dichloroethylene-metabolites inthe lungs of adult and weanlingmale and female mice: Correla-tion with severities of bronchiolarcytotoxicity, 1484
Fossati, G., see Patrini, G., 172Fowler, K. W., see Bencherif, M., 1413Fox, A. W., Sullivan, B. W., Buffini, J. D.,
Neichin, M. L., Nicora,R.,Hoehier, F. K., O�Rourke, R. andStoltz, R. R.: Reduction of serumlactate by sodium dichloroac-etate, and human pharmacoki-netic-pharmacodynamic relation-ships, 686
Fox, J. A., Hotaling, T. E., Struble, C.,Ruppel, J., Bates, D. J., and
1596 Index VoL 279
Schoenhoff, M. B.: Tissue distri-bution and complex formationwith IgE of an anti-IgE antibodyafter intravenous administrationin cynomolgus monkeys, 1000
Fox-Threlkeld, J. E. T., see Vergara, P.,306
Free radicals, effects on K� channels innon-neurogenic relaxation, in ca-nine airway muscle, 813
Friedlaender, M. H., see Woodward, D. F.,
137Frontal cortex, chronic antidepressants
and 5-HT7 receptor activity in, inrat astrocytes, 1551
Fuchs, R. A., see Baker, D. A., 392Fujisawa, Y., see Masuda, Y., 675Furosemide, effects on cardiac hypertro-
phy, in spontaneously hyperten-sive rats, 983
Furukawa, T., see Mukai, M., 822
Gadbois, T., see Bowersox, S. S., 1243Gainer, J. V., see Brown, N. J., 703Galeotti, N., see Ghelardii, C., 884Gallagher, M. J., see Lynch, D. R., 154Ganglia, sympathetic, inhibition by dopa-
mine receptors, in canine heart,822
Gangliosides, effects against ethanol do-pendence, 128
Garner, J. E., see Walsh, S. L., 524Gartside, S. E., McQuade, R. and Sharp,
T.: Effects of repeated admiis-tration of 3,4-methyl-enedioxymethamphetamine on5-hydroxytryptamine neuronalactivity and release in the ratbrain in vivo, 277
Garvey, D. S., see Delyani, J. A., 1174Gastric acid secretion
inhibition by secretin, in canine, 718TP-680 effects on, 1404
Gastric mucosa, leminoprazole cytoprotec-tion in, in rabbit, 975
Gastrointestinal tract, cholecystokininmechanisms of action in, in ca-nine, 306
GDNF, see Glial cell-line derived neurotro-phic factor
Gender-related differences, in morphineantinociception, 767
Gene transfer, lipid-mediated, plasmid de-livery efficiency after, 1462
Genescardiac, diuretic effects on, in spontane-
ously hypertensive rats, 983PNMT, and Egr-l mRNA expression, in
rat adrenal gland, 379prostaglandin G/H synthase-2, thymo-
cyte expression, in rats, 1566selection for ethanol tolerance, in mouse
lines, 1310and striatal cholinergic neurons, in
mouse, 1430Gerber, J. G. and Payne, N. A.: Secretin
inhibits canine gastric acid secre-tion in response to pentagastrinby modulating gastric histaminerelease, 718
Gerber, N., see Koudriakova, T., 1300Gerhardt, G. A., see Hebert, M., 1181Gessa, G. L., see Ghelardii, C., 884
Geyer, M. A., see Swerdlow, N. R., 1290
Ghanayem, B. I., see Nomeir, A. A., 222
Ghelardini, C., Galeotti, N., Figii, M., Im-perato, A., Nicolodi, M., Sicuteri,F., Gessa, G. L and Bartolini, A.:The central cholinergic systemhas a role in the antinociceptioninduced in rodents and guineapigs by the antimigraine drugsumatriptan, 884
Giant migrating contractions, PAF-in-duced, during ileal inflammation,207
Giebisch, G., see Aleo, M. D., 1318Gill, G. S., see Merchant, K. M., 1392
Giuliani, A., see Prete, S. P., 1574Glaser, K. B., see Mayer, A. M. S., 633Glial cell-line derived neurotrophic factor,
functional effects, in rat striatum,1181
Glidden, P., see Ehlert, F. J., 1335Glucocorticoids, aging and, 478Glucose, high, fibronectin turnover effects,
silibinin and antioxidants and,1520
Glutamateneurotoxicity
lubeluzole protective effects against,759
trimethylamine preventive effectsagainst, 194
and vincristine neuropathy, 410Glutathione S-transferase
glyceryl trinitrate biotransformation by,in rat aorta, 1527
inhibition, glyceryl trinitrate actionsand, 1535
Glyceryl trinitrate
biotransformation by rat aortic GSTs,1527
pharmacological actions after GST inhi-bition, 1535
Glycine receptorsantagonist L-701,324, behavioral pro-
ifie, 492[3H]MDL 105,519 site, 62potentiation by ethanol, in mouse spinal
neurons, 1116Goldie, R. G., see Knott, P. G., 1142Gonadal steroids, vascular effects, 1Gori, E., see Patrii, G., 172Gotzsch, U., see Wiegand, H., 891Gould, E. M., see Waterhouse, B. D., 582Gourde, P., see Harvie, P., 1009
Granger, P., see Itier, V., 1092Granisetron, repeated, delayed emesis by,
in piglet, 255Grant, C., see Mather, L. B., 291Gray, E., see Mather, L. E., 291Gray, J. A., see Lippiello, P. M., 1422Graziani, G., see Local, P. M., 416Graziani, G., see Prete, S. P., 1574Greiner, J. W., see Prete, S. P., 1574Gr#{233}lot,L., Le Stunff, H., Milano, S.,
Blower, P. R. and Remain, D.: Re-peated administration of the5-HT3 receptor antagonist granis-etron reduces the incidence of do-layed cisplatin-induced emesis inthe piglet, 255
Greven, J., see Hohage, H., 1086Griffin, M. T., see Ehiert, F. J., 1335Griffin, R. J., see Nomeir, A. A., 222Grigoryan, G., see Lippiello, P. M., 1422Grisoll, S., see Mifina, M.-D., 194Griswold, D. E., see Badger, A. M., 1453Gross, R. S., see Baron, B. M., 62
GST, see glutathione S-transferase
Guengerich, F. P., see Kim, R. B., 4Guerif, S., see Soulard, C. D., 1379Guidotti, A., see Oberto, A., 435Gulakowski, R. J., see Currens, M. J., 645Gustafson, K. R., see Currens, M. J., 645
H-7, see 1(5-Isoquinolinesulfonyl)-2methyl piperazine
H-8, see N-[(Methylamine)ethyl]-5-iso-quinoline sulfonamide
H-89, see N-[2-(p-Bromocinnamoylamin-o)ethyl]-5-isoquinoline-sulfon-amide
HA-1004, see N-(2-Quindinoethyl)-5-iso-quinoline sulfonamide
Hadac, E. M., see Holtmann, M. H., 555Hagenbuch, B., see Kontaxi, M., 1507
Haloperidol, inhibition ofNMDA receptorsby, 154
Halothane, tetra-a-helix-bundle proteinbinding, 56
Halushka, P. V., see Higashiura, K., 1386Hamaguchi, A., see Kim, S., 983Hara, A., Hashizume, H. and Abiko, Y.:
Dilazep and its derivative,K-7259, attenuate mechanical de-rangement induced by palmitoyl-L-carnitine in the isolated, per-fused rat heart, 32
Hara, Y., see Watanabe, Y., 617
Harris, D. W., see Merchant, K. M., 1392Harrison, B. L., see Baron, B. M., 62Harvie, P., Omar, R. F., Dusserre, N.,
Lansac, N., D#{233}sormeaux, A.,Gourde, P., Simard, M., Trem-blay, M., Beauchamp, D. andBergeron, M. G.: Ribavirin poten-tiates the efficacy and toxicity of
2’,3’-dideoxyinosine in the mu-rime acquired immunodeficiencysyndrome model, 1009
Hashida, M., see Sawai, K., 284Hashizume, H., see Hara, A., 32Hatzidimitriou, G., see Sparago, M., 1043Hawes, C., see Baron, B. M., 62Heart
PALCAR-induced mechanical derange-
ment, dilazep and K-7259 effectson, in rat heart, 32
sympathetic ganglia, inhibition by dopa-mine receptors, in canine, 822
Hebert, M., Van Home, C. G., Hoffer, B. J.and Gerhardt, G. A.: Functionaleffects of GDNF in normal ratstriatum: Presynaptic studies us-ing in vivo electrochemistry and
microdialysis, 1181Heisler, B. E. and Ferrier, G. R.: Proar-
rhythmic actions of flecainide inan isolated tissue model of isch-emia and reperfusion, 317
Heisted, D. D, see Taguchi, H., 1514Helterbrand, J., see Sato, M., 298Henningfield, J. B., see Evans, S. M., 1345Henningfield, J. B., see Pickworth, W. B.,
450Henry, P. J., see Knott, P. G., 1142Hepatectomy, erythropoietin pharmacoki-
netics after, in sheep, 1205Hepatotoxicity, acetaminophen, cho-
lesteryl hemisuccinate protection
against, 1470Hermenegildo, C., see Minna, M.-D., 194Heroin
esterase-mediated metabolism, 713
1996 Index 1597
inhalation exposure, antinociceptive ef-fects, in mice, 69
Herzer, W. A., see Carcillo, J. A., 1197Herzer W. A., see Jackson, E. K., 1250Hess, S. D., see Varney, M. A., 367Higashiura, K., Blaney, B., Morgan, E.,
Mathur, R. S. and Halushka, P.V.: Inhibition of testosterone 5a-reductase: Evidence for tissue-specific regulation of thrombox-ane A� receptors, 1386
Higgs, R., see Sato, M., 298Hippocampus
CAl region, excitation decrease by fel-bamate in, in rat, 1100
excitatory synaptic transmission, L-
deprenyl effects on, in rat, 740GABAA receptors
in benzodiazepine-tolerant rats, 1092mapping, 1491
nicotinic receptors, mapping, 1491NMDA receptors, lead effects on, in rat,
143Histamine
gastric release, modulation by secretin,in canine, 718
striatal release, effects of acute andchronic methamphetamine on, inrat, 271
Hitzemann, B., see Dams, K., 1430Hitzemann, R., see Dams, K., 1430HN, see Human immunodeficiency virusHL-60 cells
apoptosis induction by CoA-independenttransacylase inhibitors, 956
superoxide generation, 633Ho, A., see Zhou, Y., 351Hodges, H., see Lippiello, P. M., 1422Hoehler, F. K., see Fox, A. W., 686Hoffer, B. J., see Hebert, M., 1181Hoffman, P. L., see Snell, L. D., 128Hohage, H., Querl, I. U., M#{246}rth,D. M. and
Greven, J.: The basolateral or-ganic cation transport system ofrabbit kidney proximal tubules.Influence of anorganic anions,1086
Hoischen, S., see Mttller-Ehmsen, J., 1220Holsapple, M. P., see Matulka, R. A., 3Holtmann, M. H., Hadac, E. M., Ulrich, C.
D. and Miller, L. J.: Molecular ba-515 and species specificity of highaffinity binding of vasoactive in-testinal polypeptide by the rat so-cretin receptor, 555
Holycross, B. J., see Bergman, M. R., 247H#{246}nack,D., see Loscher, W., 561H#{246}nack,D., see Loscher, W., 573Hong, J.-Y., see Forkert, P. G., 1484
Hoogerkamp, A., Arends, R. H. G. P.,Bomers, A. M., Mandema, J. W.,Voskuy, R. A�, and Danhof, M.:
Pharmacokinetic/pharmacody-namic relationship of benzodiaz-epines in the direct cortical stim-ulation model of anticonvulsanteffect, 803
Horie, T., see Masubuchi, Y., 724Hormones, regulation of female-dominant
sulfotransferases by, in rat liver,386
Horwitz, J. A., see Picker, M. J., 1130Hotaling, T. E., see Fox, J. A., 1000
Hsu, K.-S., Huang, C.-C., Su, M.-T. andTsai, J.-J.: L-Deprenyl (selegiline)
decreases excitatory synaptictransmission in the rat hip-pocampus via a dopaminergicmechanism, 740
5-HT, see 5-Hydroxytryptamine
HT-29 cells, CEA expression, effects of5-fluorouracil on, 1574
Huang, C.-C., see Hsu, K.-S., 740Huang, J. and Casida, J. B.: Characteriza-
tion of [3H]ethynylbicycloortho-benzoate ([3H]EBOB) bindingand the action of insecticides onthe -y-aminobutyric acid-gatedchloride channel in cultured cere-bellar granule neurons, 1191
Huang, J. L., see Mather, L. E., 291Huang, S.-J., see Mazzola-Pomietto, P.,
782Huff, R. M., see Merchant, K. M., 1392Hughes, B. W., see Bebok, Z., 1462
Human immunodeficiency virusinhibition by calanolide A, 645reverse transcriptase, inhibition by cal-
anolide A, 652Hursey, M., see Vistica, D. T., 1018Hurst, H. E., see Ma, V., 340Hutson, P. H., see Bristow, L. J., 492Hydrogen, secretion of, modulation by
PKC, in rabbit parietal cells, 97Hydromorphone, cocaine interactions, in
humans, 5243-Hydroxylation, quinine, by cytochrome
P450 isoforms, in liver, 13275-Hydroxytryptamine
function, effects of repeated MDMA on,in rat, 277
mitogen-activated protein kinase activa-tion by, in vascular smooth mus-cle, 1541
release in brain, effects of repeatedMDMA on, in rat, 277
releasers, neuroendocrine pharmacol-ogy, 1261
5-Hydroxytryptamine� receptors, desen-sitization by chronic fluoxetine,1035
5-Hydroxytryptamine3 receptors, antago-nist granisetron, delayed emesisby, in piglet, 255
5-Hydroxytryptamine7 receptors, chronicantidepressants and, in rat fron-tocortical astrocytes, 1551
5-Hydroxytryptamine2 receptors, ziprasi-done and, PET analysis, 939
Hypertension, spontaneousangiotensin II effects on renal cAMP re-
lease in, in rat, 114carvedilol effects on survival in, in
stroke-prone rats, 948effects of diuretics on cardiac hypertro-
phy in, in rats, 983Hypertrophy, cardiac, diuretic effects on,
in spontaneously hypertensiverats, 983
Hypothalamus, CRF and CRF-Rl mRNAlevels after binge cocaine admin-istration, in rat, 351
Hypothermia, early neuroprotective ef-fects against metabolic stress,332
Iatsimirskaia, E., see Koudriakova, T.,1300
Igarashi, S., see Masubuchi, Y., 724IGROV-l cells, effects ofendogenous TNF
secreted by, 84
Ijzerman, A. P., see MathSt, R. A. A., 1439Ikezawa, K., see Kaminuma, 0., 240IL, see Interleukinileal inflammation, PAl contractile effects
during, 207Imaizumi, Y., see Nomura, Y., 830Imidazoline, platelet binding sites, 694Imidazoquinazolines, NNC 14-0185 and
NNC 14-0189, tolerance and de-pendence liability, in mice seizuremodels, 573
Imipramine, inactivation of CYP2D by, inrat liver microsomes, 724
Immune cells, opioid receptor density,morphine and methadone effectson, on murine splenocytes, 172
Immune function, antiarthritic effects ofSB 203580 on, in animal models,1453
Immunodeficiency, see Acquired iminuno-deficiency syndrome; Human im-munodeficiency virus
Immunoglobulin E, antthuman anti-IgEantibody, in monkeys, 1000
Immunotoxicity, cocaine, in B6C3F1 andDBA/2 mice, 3
Imperato, A., see Ghelardini, C., 884
Indomethacincombined with anti-1L4, effect on tumor
metastasis, 472cytotoxicity, leminoprazole protection
against, in rabbit gastric mucosalcells, 975
Infarcts, size, lubeluzole effects on, in ratphotochemical stroke model, 748
Inflammation, ileal, PAY contractile ef-fects during, 207
Inhalationcarbon dioxide, inhibitory effects on pul-
monary stretch receptors, in rat>bit, 402
opioid, antinociceptive effects, in mice,69
Injuryischemia/reperfusion
focal, lubeluzole neuroprotection in, in
rat photochemical stroke model,748
-induced arrhythmias, Re 22-9194 ef-fects on, in dogs, 877
mesenteric, norepinephrmne combinedwith Re 20-1724 and, in endotox-emic rats, 1197
myocardial, MCI-154 effects on, inguinea pig heart, 47
myocardial, NO-tPA effects against,in cats, 1174
proarrhythmic effects of flecainide in,in tissue model, 317
red blood cells, adenosine deaminase re-lease by, 1250
Insecticides, action on GABA-gated chlo-ride channel, in cerebellar gran-ule neurons, 1191
Insulin-dependent diabetes, aminoguani-
dine effects on, in nonobese dia-betic mice, 790
Interferon-gamma, in met-enkephalin an-
tiviral effects, in murine cells,1268
Interleukin-4anti-HA effect on tumor metastasis, 472pharmacokinetics, effects ofsoluble IL-4
receptors on, in mouse, 340
1598 Index Vol. 279
soluble, receptors effects on murine IL-4pharmacokinetics, 340
Interleukin-5, suppression by T-440, inPBMCs, 240
Ion channels, inhibition by protamine, inbovine adrenal medullary cells,838
Ischemia/reperfusion injuryarrhythmias, Re 22-9194 effects on, in
dogs, 877
focal, lubeluzole neuroprotection in, in
rat photochemical stroke model,748
mesenteric, norepinephrine combinedwith Re 20-1724 and, in endotox-emic rats, 1197
myocardialMCI-154 effects on, in guinea pig
heart, 47NO-tPA effects against, in cats, 1174
proarrhythmic effects offlecainide in, intissue model, 317
Ishisu, R., see Abe, Y., 47Ishizaki, T., see Kim, R. B., 4Ishizaki, T., see Thao, X.-J., 1327S(-)-4-{-[2-(Isochroman-1-yl)ethyl]pipera-
zin-lyl)benzenesulfonamide, seeU-101387
Isoquinoline sulfonamides, effects on pan-etal cell function, in rabbit, 97
l(5-Isoquinolinesulfonyl)-2 methyl pipera-zine, effects on parietal cell func-tion, in rabbit, 97
Itching, allergic conjunctival, mediationby ketorolac, 137
Itier, V., Granger, P., Perrault, G., Depoor-tore, H., Scatton, B. and Avenet,P.: Protracted treatment with di-azepam reduces benzodiazepine1receptor-mediated potentiation of
‘y-aminobutyric acid-induced cur-rents in dissociated rat hippocam-pal neurons, 1092
Ito, C., Onodera, K., Sakurai, E., Sato, M.and Watanabe, T.: Effects of do-
pamine antagonists on neuronalhistamine release in the striatumof rats subjected to acute andchronic treatments with metham-phetamine, 271
Ito, K., see Nomura, Y., 830Itoh, Y., see Masuda, Y., 675Iversen, P., see Sato, M., 298Iwao, H., see Kim, S., 983Izumi, F., see Minami, K., 838
Jachec, C., see Varney, M. A., 367Jackman, H. L., see Deddish, P. A., 1582Jackson, B. K., see Carcfflo, J. A., 1197Jackson, E. K., see Vyas, S. J., 114Jackson, B. K., Mi, Z., Koehler, M. T., Car-
cillo, J. A., Jr. and Herzer W. A.:Injured erythrocytes releaseadenosine deaminase into the cir-culation, 1250
Jan, 5., see Kolesnikov, Y. A., 502Janssen, L. J. and Wattie, J.: Non-neuro-
genic electrically evoked relax-ation in canine airway muscle in-volves action of free radicals onK’ channels, 813
Janssen, M., see De Ryck, M., 748
Jiang, M., see Tseng, G.-N., 865Johansson, J. S., Rabanal, F. and Dutton,
P. L: Binding of the volatile an-esthetic halothane to the hydro-
phobic core of a tetra-a-helix-bundle protein, 56
Johnson, E. C., see Varney, M. A., 367Johnson, S. W., see Wu, Y.-N., 457Jordan, S. see Matulka, IL A., 3Joseph, T., Coirault, C., Ducros, L., and
Lecarpentier, Y.: Mechanical andenergetic effects of cromakalim
on guinea pigleft ventricular pap-illary muscle, 464
Jou#{235}t,P. and Sarna, S. K.: Platelet-activating factor (PAY) stimu-lates giant migrating contrac-tions during ileal inflammation,207
K-7259, effects on PALCAR-induced me-chanical derangement, in ratheart, 32
Kathorn, T. see Bennett, G. D., 1237Kallender, H., see Wilson, S., 214Kamendulis, L M., Brzezinski, M. R., Pin-
del, E. V., Bosron, W. F. andDean, R. A.: Metabolism of co-caine and heroin is catalyzed bythe same human liver carboxyles-terases, 713
Kaminuma, 0., Mori, A., Suko, M.,Kikkewa, H., Ikezawa, K. andOkudaira, H.: Interleukin-5 pro-duction by peripheral bloodmononuclear cells of asthmaticpatients is suppressed by T-440:Relation to phosphodiesterase in-hibition, 240
Kanagawa, K., see Tachibana, I., 1404Kanazawa, T., see Murakami, M., 877Kato, Y., see Kim, S., 983
Katz, see Sparago, M., 1043Kawata, A., see Masuda, Y., 675
Keersmaekers, R., see De Ryck, M., 748
Kenney, S., see Vistica, D. T., 1018Keratin, succinylated fragment, SOD con-
jugate, effects, 162Ketorolac, antipruritic effects, 137Khroyan, T. V., see Baker, D. A., 392Kidney, see also under Renal
cAMP release, angiotensin II effects on,in spontaneously hypertensiverat, 114
GABA agonist effects on, in rat, 602oligonucleotide disposition, in rat, 284paraquat transport, in LLC-PK1 cells,
625proximal tubules
basolateral organic cation transportsystem, in rabbit, 1086
nitric oxide generation by, 91Kidney cortex, dicarboxylate carrier, flue-
rescein interactions, in rat mite-chondria, 1559
Kidney damage, carvedilol effects on, instroke-prone spontaneously hy-pertensive rats, 948
Kidney failure, in endotoxemia, norepi-nephrine combined with Re 20-1724 treatment, in rats, 1197
Kikkewa, H., see Kaminuma, 0., 240Kikuchi, T., see Masuda, Y., 675Kim, R. B., Yamazaki, H., Chiba, K.,
O’Shea, D., Mimura, M.,Guengerich, F. P., Ishizaki, T.,
Shimada, T. and Wilkinson, G.R.: In vivo and in vitro character-ization ofCYP2E1 activity in Jap-
anese and Caucasians, 4
Kim, S., Hamaguchi, A., Shinkawa, T.,Kato, Y., Tsuchiya, N., Miura, K.,
Ohta, K. and Iwao, H.: Moleculareffects of M17055, furosemideand thiazide on cardiac hypertro-phy of spontaneously hyperten-sive rats, 983
Kinaseinhibitor effects on superoxide genera-
tion in HL-60 cells, 633inhibitor SB 203580, pharmacological
proffle, in animal models, 1453mitogen-activated protein, activation by
serotonin, in vascular smoothmuscle, 1541
King, S. A., see Bebok, Z., 1462Kininase II, characterization and proper-
ties, 1582Kinukawa, M., see Murakami, M., 877Kirk, K. L., see Beb#{246}k,Z., 1462
Kistard, J. A., see Widness, J. A., 1205Klaassen, C. D., see Liu, L., 386Kleven, M. S. and Kook, W.: Differential
effects ofdirect and indirect dopa-mine agonists on eye blink rate in
cynomolgus monkeys, 1211Knecht, M., see Todaka, K., 120Knippenberg, R. W., see Kudlacz, E. M.,
732Knott, P. G., Fernandes, L. B., Henry, P. J.
and Goldie, R. G.: Influence of en-dothelin-1 on cholinergic nerve-mediated contractions and acetyl-choline release in rat isolatedtracheal smooth muscle, 1142
Kobayashi, T., Matsuno, K., Nakata, K.and Mita, S.: Enhancement ofacetylcholine release by SA4503,a novel o� receptor agonist, in therat brain, 106
Koehler, M. T., see Jackson, E. K., 1250
Koek, W., see Kleven, M. S., 1211Kolesnikov, Y. A., Jam, S., Wilson, R. and
Pasternak, G. W.: Peripheralmorphine analgesia: Synergywith central sites and a target ofmorphine tolerance, 502
Kontaxi, M., Eckhardt, U., Hagenbuch, B.,Stieger, B., Meier, P. J. and Petz-inger, E.: Uptake of the myco-toxin ochratoxin A in liver cellsoccurs via the cloned organic an-ion transporting polypeptide,1507
Kostenis, E., see Tranlde, C., 926Koudriakova, T., Iatsimirskaia, E., Thle-
baev, S., Spetie, D., Utkin, I.,Mullet, D., Thompson, T., Vouros,
P. and Gerber, N.: In vivo dispo-sition and metabolism by liverand enterocyte microsomes of theantitubercular drug rifabutin inrats, 1300
Kozlowski, R. Z., see Salter, K. J., 1053Kraft, A. S., see Bebok, Z., 1462Kramer, U., see Wiegand, H., 891Krause, D. N., see Duckles, S. P., 1Kreeger, J. S. and Larson, A. A.: The sub-
stance P amino-terminal metabo-lite substance P(l-7), adminis-tered peripherally, prevents thedevelopment of acute morphinetolerance and attenuates the ex-pression of withdrawal in mice,662
1996 Index 1599
Kreek, M. J., see Yu, J., 507Kreek, M. J., see Zhou, Y., 351Kudlacz, E. M., Knippenberg, R. W., Lo-
gan, D. E. and Burkholder, T. P.:Effect ofMDL 105,212, a nonpep-tide NK-1/NK-2 receptor antago-nist in an allergic guinea pigmodel, 732
Kuhar, M. J., see Fleckenstein, A. E., 200
Kukkonen, J. P., Nasman, J., Ojala, P.,Oker-Blom, C. and Akerman, E.0.: Functional properties of mus-carinic receptor subtypes Hml,Hm3 and Hm5 expressed in Sf9
cells using the baculovirus ex-pression system, 593
Kulagowski, J. J., see Bristow, L. J., 492Kuo, A., see Muzykantov, V. R., 1026Kurl, R. N., see Olnes, M. J., 1566Kushiku, K., see Mukai, M., 822Kv4.2, blockade by 4-aminopyridine, 865Kvl.2, quiidine effects on, 844
Kwon, V., Lee, R. D. and Morris, M. E.:Hepatic uptake of choline in ratliver basolateral and canalicularmembrane vesicle preparations,774
L-701,324, anticonvulsant and behavioral
profile, 492L929 cells, effects of endogenous TNF
against, 84Lacal, P. M., D’Atri, S., Orlando, L., Bon-
massar, E. and Graziarn, G.: Invitro inactivation of human O�-alkylguanine DNA alkyltrans-ferase by antitumor triazene com-pounds, 416
Lactate, serum, reduction by sodium di-chioroacetate, 686
Ladurner, A., see Wilson, S., 214LaForge, K. S., see Zhou, Y., 351Laker, I., see Xie, H., 668Lansac, N., see Harvie, P., 1009Laragh, J. H., see Barone, F. C., 948Larson, A. A., see Kreeger, J. S., 662Laser desorption/ionization mass spec-
trometry, matrix-assisted, dynor-phin A (1-17) biotransformation,human and rhesus monkey blood,507
Laudignon, N., see Desta, B., 1077Lazzaro, V. A., see Chan, B. S. H., 625Le Stunif, H., see Gr#{233}lot,L., 255Lead
allosteric structures, 926neurotoxicity and apoptotic effects, in
newborn rat, 435NMDA receptor effects, in rat hippocam-
pal neurons, 143Lecarpentier, Y., see Joseph, T., 464Lee, J. C., see Badger, A. M., 1453Lee, R. D., see Kwon, Y., 774Lee, R. P., see Forkert, P. G., 1484
Lee, S-F., see Nigam, R., 1527Leeson, P. D., see Bristow, L. J., 492Lefebvre, M., Caille, G. and Du Souich, P.:
Organ-specific pattern of inhibi-tion of diltiazem metabolism atsteady state in rabbits, 902
Lefer, A. M., see Delyani, J. A., 1174Left ventricular papillary muscle,
mechano-energetic effects of cro-
makalim on, in guinea pig, 464Lemaire, M., see Yamada, T., 1357
Leminoprazole, cytoprotective effects, inrabbit gastric mucosal cells, 975
Leon, I., see Meade, C. J., 1148
Lesage, A. S., Peeters, L. and Leysen, J.E.: Lubeluzole, a novel long-termneuroprotectant, inhibits the glu-tamate-activated nitric oxide syn-thase pathway, 759
Levine, R. A., see Nandi, J., 97Levosimendan, effects on myocardial con-
tractility and oxygen consump-tion, 120
Levy,A. D.,seeLi,Q., 1261Lewis, J. W., see Butelman, B. R., 934
Lewis, J. W., see Zernig, G., 23Lewis, S. J., see Peters, T. S., 918Leysen, J. E., see Lesage, A. S., 759Li, Q., Muma, N. A. and Van De Kar, L. D.:
Chronic fluoxetine induces agradual desensitization of 5-HT�receptors: Reductions in hypotha-lamic and midbrain G. and G0proteins and in neuroendocrineresponses to a 5-HT1A agonist,1035
Li, Q., Murakami, I., Stall, S., Levy, A. D.,Brownfield, M. S., Nichols, D. E.and Van de Kar, L. D.: Neuroen-docrine pharmacology ofthree se-rotonin releasers: 1-(l,3-Benzodi-oxol-5-yl)-2-(methylamino)butane(MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAI) and p-meth-ylthioamphetamine (MTA), 1261
Lichtman, A. H., Meng, Y. and Martin, B.R.: Inhalation exposure to volatil-ized opioids produces antinocicep-tion in mice, 69
Ling, S., see Tseng, G.-N., 844Lipid-mediated gene transfer, plasmid do-
livery efficiency after, 1462Lipid A, cytotoxicity, nitric oxide effects in,
91Lipopolysaccharide, inhibition of ACh-
and NO-mediated vasodilationby, 918
Liposome-mediated gene transfer, plas-mid delivery efficiency after, 1462
Lippiello, P. M., see Bencherif, M., 1413Lippiello, P. M., Bencherif, M., Gray, J. A.,
Peters, S., Grigoryan, G., Hodges,H. and Collins, A. C.: RJR-2403:A nicotinic agonist with CNS so-lectivity II. In vivo characteriza-tion, 1422
Liu, L. and Klaassen, C. D.: Ontogeny andhormonal basis of female-domi-nant rat hepatic sulfotrans-ferases, 386
Liu, W., see Abrahams, T. P., 967Liver
acetaminophen toxicity, cholesterylhemisuccinate protection against,1470
choline uptake, in rat basolateral mem-brane vesicles and canalicularmembrane vesicles, 774
cocaine toxicity, in rat, 359cytochrome P450
inhibition during diltiazem biotrans-formation, in rat, 1447
isoforms in quinine metabolism, 1327cytochrome P450 2D inactivation, impi-
pramine-induced, in rat micro-somes, 724
heroin metabolism, carboxylesterase-mediated, 713
membrane vesicles, choline uptake, inrat, 774
microsomesquinine metabolism, cytochrome P450
isoforms in, 1327stanozolol binding site, in male rat,
1123ochratoxin A uptake, 1507rifabutin metabolism, in rats, 1300sulfotransferases, female-dominant, on-
togeny and hormonal basis, 386Livni, E., see Christian, B. T., 325Llansola, M., see Mi#{241}na, M.-D., 194LLC-PK1 cells, paraquat transport by, 625Locomotion, cocaine-induced, intra-ac-
cumbens sulpiride and, 392
Logan, D. E., see Kudlacz, E. M., 732Look, Z., see Bowman, M. A., 790Lookingland, K., see Merchant, K. M.,
1392Lopez-Anaya, A., see Aleo, M. D., 1318Loscher, W., Rundfeldt, C., H#{246}nack, D.
and Ebert, U.: Long-term studieson anticonvulsant tolerance andwithdrawal characteristics ofbenzodiazepine receptor ligandsin different seizure models inmice. I. Comparison of diazepam,clonazepam, clobazam and abe-
carnil, 561Loscher, W., Rundfeldt, C., H#{246}nack, D.
and Ebert, U.: Long-term studieson anticonvulsant tolerance andwithdrawal characteristics ofbenzodiazepine receptor ligandsin different seizure models inmice. II. The novel imidazoquina-zolines NNC 14-0185 and NNC
14-0189, 573Lovette, M. E., see Bencherif, M., 1413
Lowe, L. S., see Widness, J. A., 1205Lubeluzole, neuroprotective effects
in focal ischemia, in rat photochemicalstroke model, 748
against glutamate toxicity, 759Luchetta, R., see Bowman, M. A., 790Ludbrook, G. L., see Mather, L. E., 291Lung
arterial myocytes, endothelin receptorcoupling to potassium and chlo-ride channels in, in rat, 1053
1,1-dichloroethylene metabolism, inadult and weanling mice, 1484
fibrinolytic targeting to, 1026stretch receptors, inhibitory effects of
CO2 inhalation on, in rabbit, 402vasculature, antibody-conjugated plas-
minogen activator targeting to,1026
Luther, R. R., see Bowersox, S. S., 1243Lutzke, B. S., see Merchant, K. M., 1392
Luzardo, 0. P., see Boada, L. D., 1123Lynch, D. R. and Gallagher, M. J.: Inhibi-
tion of N-methyl-D-aspartate re-ceptors by haloperidol: Develop-mental and pharmacologicalcharacterization in native and re-combinant receptors, 154
M17055, effects on cardiac hypertrophy, inspontaneously hypertensive rats,983
Ma, Y., Hurst, H. E. and Fernandez-Botran, R.: Soluble cytokine re-
1600 Index
ceptors as carrier proteins: Ef-fects of soluble interleukin-4receptors on the pharmacokinet-ics of murine interleukin-4, 340
Maclaren, N. K., see Bowman, M. A., 790Maeda, H., see Noda, J., 162Maeda, N., see Yamazaki, M., 1157Maggos, C. E., see Thou, Y., 351Mahato, R. I., see Sawai, K., 284Mancuso, T., see Debernardis, D., 84Mandema, J. W., see Hoogerkamp, A., 803Mao, L. and Abdel-Rahman, A. A.: Syner-
gistic behavioral interaction be-tween ethanol and clonidine inrats: Rele of alpha-2 adrenocep-tors, 443
MAPK, see Mitogen-activated protein ki-nase
Marchioro, M., Swanson, K. L., Aracava,Y. and Albuquerque, E. X.: Gly-cine- and calcium-dependent ef-fects oflead on N-methyl-D-aspar-tate receptor function in rathippocampal neurons, 143
Mariner, J. M., see Currens, M. J., 645Mariner, J. M., see Currens, M. J., 652Markham, P., see Nomeir, A. A., 222Marks, N., see Oberto, A., 435Markus, R. P., Zago, W. M. and Carneiro,
R. C. G.: Melatonin modulation ofpresynaptic nicotinic acetylcho-line receptors in the rat vas defer-ens, 18
Martin, B. R., see Lichtman, A. H., 69Maruyama, K., see Murakami, M., 877Masci, G., see Prete, S. P., 1574Masereeuw, R., Saleming, W. C., Miller, D.
S. and Russel, F. G. M.: Interac-tion of fluorescein with the dicer-boxylate carrier in rat kidney cor-tex mitochondria, 1559
Masonis, A. B. T. and McCarthy, M. P.:Effects ofthe androgenic/anabolicsteroid stanozolol on GABAA re-ceptor function: GABA-stimu-lated 36C1 influx and [355] TBPSbinding, 186
Mass spectrometry, matrix-assisted laserdesorption/ionization, dynorphinA (1-17) biotransformation, hu-man and rhesus monkey blood,507
Massi, P., see Patrii, G., 172Masubuchi, Y., Igarashi, S., Suzuki, T.,
Hone, T. and Narimatsu, S.: Imi-pramine-induced inactivation of acytochrome P450 2D enzyme inrat liver microsomes: In relationto covalent binding of its reactiveintermediate, 724
Masuda, Y., Sugo, T., Kikuchi, T., Kawata,A., Satoh, M., Fu.jisawa, Y., Itoh,Y., Wakimasu, M. and Ohtaki, T.:Receptor binding and antagonistproperties of a novel endothelinreceptor antagonist, TAK-044 {cy-clo[-D-a-aspartyl-3-[(4-phe-nylpiperazin-1-yl)carbonyll-L-ala-
nyl-L-a-aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl]disodium salt), inhuman endothelinA and endo-thelin9 receptors, 675
Mather, L. E., Upton, R. N., Huang, J. L.,Ludbrook, G. L., Gray, E. and
Grant, C.: The systemic and cere-bra! kinetics of thiopental insheep: Enantiomeric analysis,291
Matheson, S., see Bristow, L. J., 492Mathewson, C., see Picker, M. J., 1130Math#{244}t,R. A. A., Van der Wenden, B. M.,
Soudijn, W., Breimer, D. D., Ijz-erman, A. P. and Danhof, M.: Par-tial agonism of the nonselectiveadenosine receptor agonist 8-bu-tylaminoadenosine at the A1 ro-ceptor in vivo, 1439
Mathur, R. S., see Higashiura, K., 1386Matrix-assisted laser desorption/ioniza-
tion mass spectrometry, dynor-phin A (1-17) biotransformation,human and rhesus monkey blood,507
Matsumoto, S., Okamura, H., Suzuki, K.,Sugai, N. and Shiniizu, T.: Inhib-itory mechanism of CO2 inhala-tion on slowly adapting pulmo-nary stretch receptors in theanesthetized rabbit, 402
Matsuno, K., see Kobayashi, T., 106
Matsuoka, N., see Yamazaki, M., 1157Matuilca, R. A., Jordan, S. D., Stanulis, E.
D. and Holsapple, M. P.: Evalua-tion of sex- and strain-depen-dency of cocaine-induced immu-nosuppression in B6C3F1 andDBA/2 mice, 3
Mayer, A. M. S., Brenic, S. and Glaser, K.B.: Pharmacological targeting ofsignaling pathways in protein ki-nase C-stimulated superoxidegeneration in neutrophil-likeHL-60 cells: Effect of phorbol es-ter, arachidonic acid and inhibi-tors of kinase(s), phosphatase(s)and phospholipase A�, 633
Mayer, R. J., see Winkler, J. D., 956Mayeux, P. R., see Traylor, L. A., 91Mazzola-Pomietto, P., Aulakh, C. S.,
Huang, S.-J. and Murphy, D. L.:Repeated administration of meta-chiorophenylpiperazine or 1-(2,5-dimethoxy-4-iodophenyl)-2-amin-opropane produces tolerance toits stimulatory effect on adreno-corticotropin hormone but notprolactin or corticosterone secre-tion in rats, 782
Mazzone, A., see Patrini, G., 172Mazzuccheffi, I., see Patrini, G., 172MBDB, see 1-(1,3-Benzodioxol-5-yl)-2-
(methylamino)butaneMcCall, R. B., see Merchant, K. M., 1392McCarthy, M. P., see Masonis, A. E. T., 186
McCook, C., see Slotkin, T. A., 478MCI-154, effects on ischemic dysfunction,
in guinea pig heart, 47McIntosh, L. J., see Wiegand, H., 891McMahon, J. B., see Currens, M. J., 645McMahon, J. B., see Currens, M. J., 652m-CPP, see Meta-chiorophenylpiperazineMcQuade, R., see Gartside, S. B., 277MDL 105,212, effects in allergic response,
in guinea pig model, 732MDL 105,519, NMDA receptor-glycine
site, 62MDMA, see 3,4-Methylenedioxymetham-
phetamine
Vol. 279
Meade, C. J., Mierau, J., Leon, I. and Ens-inger, H. A.: In vivo role of theadenosine A3 receptor: N#{176}-2-(4-Aminophenyl)ethyladenosine in-duces bronchospasm in BDE ratsby mast-like cell-mediated andneurally mediated mechanisms,1148
Meier, P. J., see Kontaxi, M., 1507Melanoma, B16 tumor progression, anti-
IL4 effect on, 472Melatonin, modulation of nAChRS by, in
rat vas deferens, 18Memory, enhancement by FK960, in rats,
1157Meng, Y., see Lichtman, A. H., 69Meperidine, inhalation exposure, antinoci-
ceptive effects, in mice, 69Merchant, K. M., Gifi, G. S., Harris, D. W.,
Huff, R. M., Eaton, M. J., Look-ingland, K., Lutzke, B. S., Mc-Call, R. B., Piercey, M. F.,Schreur, P. J. K. D., Sethy, V. H.,Smith, M. W., Svensson, K. A.,Tang, A. H., Vonvoigtlander, P. F.and Tenbrink, R E.: Pharmaco-logical characterization ofU-101387, a dopamine D4 recep-tor selective antagonist, 1392
Mesangial cells, fibronectin turnover, sill-binin effects on, 1520
Mesenteric blood flow, in endotoxemia,norepinephrine combined with Re20-1724 and, in rats, 1197
Messenger RNA
CRF and CRF-Rl, levels after binge co-
caine administration, in rat, 351Egr-1, neural control of, in rat adrenal
gland, 379Metabolic stress, hypothermia and neuro-
protection against, 332Metabolism
diltiazemorgan-specific, in rabbits, 902P450 inhibition during, in rat liver,
1447
glyceryl trinitrate, by rat aortic GSTs,1527
heroin, esteraso-mediated, 713methylether derivative of (±)-
BW373U86, 1069
nalidixic acid, species differences in, 222quinine, by cytochrome P450 isoforms,
in liver, 1327rifabutin, in rats, 1300
Meta-chlorophenylpiperazine, neuroendo-crine effects, tolerance, 782
Metastasis, tumor, anti-IL4 effect on, 472Met-enkephalin, see Methionine enkepha-
lin
METH, see MethamphetamineMethadone, combined with morphine, opi-
old receptors and, on murinesplenocytes, 172
Methamphetamine, acute and chronic, ef-fects on neuronal histamine ro-lease, in rat striatum, 271
Methcathinone, enantiomer effects, 1043Methionine enkephalin, antiviral effects,
in murmne cells, 1268
Methoclocinnamox, agonist and antago-nist effects, in rhesus monkeys,934
5-Methoxy-6-methyl-2-aminoindan, neu-roendocrine pharmacology, 1261
1996 Index 1601
N-[(Methylamine)ethyl]-5-isoquinolinesulfonamide, effects on parietalcell function, in rabbit, 97
N-Methyl-D-aspartate, currents in dopa-mine neurons, in rat brain, 457
N-Methyl-D-aspartate receptorsantagonist L-701,324, behavioral pro-
file,492inhibition by dynorphin, 1063inhibition by haloperidol, 154[3H]MDL 105,519-glycine site, 62modulation by lead, in rat hippocampal
neurons, 143recombinant human subtypes
NMDAR1A/2A and NMDAR1A/
2B, in mammalian cells, 367subunit-transfected CHO cells, acquired
excitotoxicity in, 5153,4-Methylenedioxymethamphetamine,
repeated, effects on 5-HT func-
tion, in rat brain, 277O6-Methylguanine-DNA methyifrans-
ferase, see 0#{176}-Alkylguanine DNAalkyltransferase
2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,l2,l2aa-octahydro-quinolino [2,3,3,-g] isoquinoline,see TAN-67
(E)-N-Methyl-4-(3-pyridinyl)-3-butene-l-amine, see RJR-2403
p-Methylthioamphetamine, neuroendo-crime pharmacology, 1261
Meyer, E. R., see Cicero, T. J., 767Mi, Z., see Carcillo, J. A., 1197Mi, Z., see Jackson, E. K., 1250Mi, Z., see Vyas, S. J., 114Michel, B., see Deddish, P. A., 1582Microsomes
impipramine-induced inactivation ofCYP2D in, in rat liver, 724
quinine metabolism, cytochrome P450isoforms in, 1327
stanozolol binding site, in male rat liver,1123
Midazolam, anticonvulsant effects, in di-rect cortical stimulation model,803
Mierau, J., see Meade, C. J., 1148
Migrating contractions, giant, PAY-in-duced, during ileal inflammation,207
Milano, S., see Gr#{233}lot,L., 255Miller, D. S., see Masereeuw, R., 1559Miller, L. J., see Holtmann, M. H., 555Miller, V. M., see Duckles, S. P., 1Mimura, M., see Kim, R. B., 4Minami, K., Yanagihara, N., Segawa, K.,
Sata, T., Tsutsui, M., Shige-matsu, A. and Izumi, F.: Inhibi-tion by protamine of catechol-amine secretion and ion influxes
in bovine adrenal medullary cellsin culture, 838
Mifina, M.-D., Hermenegildo, C., Llansola,M., Montoliu, C., Grisoli, S. andFelipo, V.: Carnitine and cholinederivatives containing a trimeth-
ylamine group prevent ammoniatoxicity in mice and glutamatetoxicity in primary cultures ofneurons, 194
Misawa, M., see Suzuki, T., 177Mite, S., see Kobayashi, T., 106Mitchell, J. A., see Damiano, B. P., 1365Mitochondria
cocaine-induced peroxidative stress ef-fects on, in rat liver, 359
dicarboxylate carrier, fluorescein inter-actions, in rat kidney cortex, 1559
Mitogen-activated protein kinaseactivation by serotonin, in vascular
smooth muscle, 1541effects on superoxide generation in
HL-60 cells, 633
Miura, K., see Kim, S., 983Miyagi, M., see Murakami, M., 877Miyata, H., see MUrakami, M., 877MMAI, see 5-Methoxy-6-methyl-2-amin-
oindanMohr, K., see Trankle, C., 926Monasterolo, L. A., see Trumper, L., 548
Monasterolo, L. A., Trumper, L., andElfas, M. M.: Effects of ‘y-ami-nobutyric acid agonists on the iso-lated perfused rat kidney, 602
Monoamine oxidase B inhibitors, i..-depre-nyl, effects on excitatory synaptictransmission, in rat hippocam-pus, 740
Monoclonal antibody, anti-IL4, effect ontumor metastasis, 472
Mononuclear cells, peripheral blood, IL-5suppression by T-440 in, 240
Montoliu, C., see Mifina, M.-D., 194Moran, R. A., see Currens, M. J., 645Moran, T., see Varney, M. A., 367Morgan, E., see Higashiura, K., 1386Mori, A., see Kaminuma, 0., 240Mori, T., see Suzuki, T., 177Morita, K., Bell, R. A., Siddall, B. J. and
Wong, D. L.: Neural stimulationof Egr-1 messenger RNA expres-sion in rat adrenal gland: Possi-ble relation to phenylethano-lamine N-methyltransferase generegulation, 379
Morphineacute, tolerance, substance P(1-7) ef-
fects on, 662
antinociceptive effectsgender-related differences in, 767pertussis toxin and, in mouse, 39
combined with methadone, opioid recep-tors and, on murine splenocytes,172
combined with �9-THC, dynorphinsand, in spinal cord, 608
dependence, substance P(1-7) effects on,662
inhalation exposure, antinociceptive ef-fects, in mice, 69
peripheral analgesia, 502place preference induced by, TAN-67 ef-
fects on, in mice, 177Morris, M. E., see Kwon, Y., 774Morrison, J. H., see Varney, M. A., 367Morrow, J. D., see Brown, N. J., 703Mortality, carvedilol effects on, in stroko-
prone spontaneously hyperten-sive rats, 948
Morth, D. M., see Hohage, H., 1086
Motor nerve terminals, calcium channelsin, w-agatoxin-WA and w-cono-toxin-MVIIC effects on, in mouse,1229
Moxonidine, platelet I� binding sites, 694MTA, see p-MethylthioamphetamineMucosa, gastric, leminoprazole cytoprotec-
tion in, in rabbit, 975
Mukai, M., Kushiku, K., Yamada, H.,Yamada, K., Dan, K. and Fu-rukawa, T.: The inhibition of gan-glionic transmission via presyn-aptic dopamine DA1 andpostsynaptic DA� receptor activa-tion in the canine cardiac sympa-thetic ganglia, 822
Muller-Ehmsen, J., Brixius, K., Hoischen,S., and Schwinger, R. H. G.: Ino-tropic and coronary vasodilatoryactions of the K-adenosinetriphosphate channel modulatornicorandil in human tissue, 1220
Mullet, D., see Koudriakova, T., 1300Muma, N. A., see Li, Q., 1035Mumaw, V. R., see Ray, S. D., 1470Murakami, I., see Li, Q., 1261Murakami, M., Kinukawa, M., Kanazawa,
T., Maruyama, K., Miyagi, M.,Miyata, H. and Ujiie, A.: Effectsofthe new class I antiarrhythmicagent Re 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyllpropionamide D-tartrate, on ischemia- andreperfusion-induced arrhythmiasin dogs: Involvement of throm-boxane A2 synthase inhibitory ac-tivity, 877
Murphy, D. L., see Mazzola-Pomietto, P.,782
Murphy, G. J., see Wilson, S., 214Murray, F., see Bristow, L. J., 492Murray, M. and Butler, A. M.: Enhanced
inhibition of microsomal cyto-chrome P450 3A2 in rat liver dur-ing diltiazem biotransformation,1447
Muscarinic receptorsaceclidine enantiomer interactions,
1335allosteric lead structures for, 926Hml, Hm3 and Hm5, functional proper-
ties, in Sf9 cells, 593-operated potassium currents, inhibi-
tion by amiodarone, 617Muscimol, renal effects, in rat, 602Muscle, see also Smooth muscle
airway, non-neurogenic relaxation in, incanine, 813
left ventricular papillary, mechano-energetic effects of cromakalimon, in guinea pig, 464
Mussap, C. J., Stamatakos, C. andBurcher, E.: Radioligand binding,autoradiographic and functionalstudies demonstrate tachykininneurokinin-2 receptors in dog urn-nary bladder, 423
Muzykantov, V. R., Barnathan, E. S.,Atochina, E. N., Kuo, A., Danilov,S. M. and Fisher, A. B.: Targetingof antibody-conjugated plasmino-gen activators to the pulmonaryvasculature, 1026
Mycotoxins, ochratoxin A, hepatocellulartransport, 1507
Myocardial ischemia/reperfusion injuryMCI-154 effects on, in guinea pig heart,
47NO-tPA effects against, in cats, 1174
Myocardiumcontractility, levosimendan effects on,
120
1602 Index Vol. 279
function, MCI-l54 effects on, in guineapig heart, 47
oxygen consumption, levosimendan ef-fects on, 120
TNF-a production in, modulation byPDE inhibitors, 247
Myocytes
pulmonary arterial, endothelin receptorcoupling to potassium and chlo-ride channels in, in rat, 1053
ventricular, cGMP effects on L-type cal-cium current and contractions in,in guinea pig, 1274
Myometrium, TP receptors in, 262
Nadeau, J., see Brown, N. J., 703Nagase, H., see Suzuki, T., 177Nakano, T., see Abe, Y., 47Nakata, K., see Kobayashi, T., 106Nakaya, H., see Watanabe, Y., 617Nalidixic acid, disposition and metabolism
of, species differences in, 222Naltrexone, effects on cocaine/opioid inter-
actions, in humans, 524Nandi, J., Bosche, M. C. and Levine, R. A.:
Effects of a phorbol ester and iso-quinoline sulfonamides on rabbitparietal cell function, 97
Naphazoline, platelet I� binding sites, 694Nanmatsu, S., see Masubuchi, Y., 724N#{228}sman, J., see Kukkonen, J. P., 593N-CPM-TAMO, see l4a,14’�3-[Dithiobis[(2-
oxo-2, 1-ethanediyl)imino-]]bis[7,8-dihydro-N-(cyclobutylm-
ethyl)-normorphinone]Necrosis, acetaminophen-induced, cho-
lesteryl hemisuccinate protectionagainst, 1470
Neichin, M. L., see Fox, A. W., 686Neisewander, J. L., see Baker, D. A., 392Nelson, A. H., see Barone, F. C., 948Nelson, S. D., see Bennett, G. D., 1237Neonates
exposed to phenobarbital, imprintedoverinduction of CYP2B1 and2B2 in, in adult rats, 991
lead neurotoxicity and apoptotic effectsin, in rat, 435
Nephrectomy, erythropoietin pharmacoki-netics after, in sheep, 1205
Nephrotoxicity, acetaminophen, in maleWistar rats, 548
Nervous systemcentral
effects of peptide drug delivery toblood-brain barrier on, in rats, 77
-selective agonist RJR-2403, in vitrocharacterization, 1413
-selective agonist RJR-2403, in vivocharacterization, 1422
enteric, in cryptosporidiosis, in piglet,1109
peripheral, morphine analgesia, 502sympathetic
inhibition by cocaine, blockade by ros-tral ventrolateral medullary al-pha-2 receptor, 967
inhibition by dopamine receptors, incanine heart, 822
Neurokinin receptorsNK-1INK-2 antagonist MDL 105,212, ef-
fects in allergic response, inguinea pig model, 732
NK-2, in dog urinary bladder, 423Neuroleptic response, cholinergic neurons
and, in mouse striatum, 1430
Neuromuscular junction, acetylcholine re-lease at, tetrandrine effects on, inmouse, 891
Neuronscholinergic, and catalepsy, in mouse
striatum, 1430dopamine, NMDA currents, in rat brain,
457Neuropathy
pain, SNX-111 spinal antinociception in,in rat models, 1243
vincristine, glutamate effects on, 410Neuroprotection
early hypothermic, against metabolicstress, 332
lubeluzole
in focal ischemia, in rat photochemicalstroke model, 748
against glutamate toxicity, 759Neurotoxicity
glutamatelubeluzole protective effects against,
759trimethylamine preventive effects
against, 194lead, in newborn rat, 435methcathinone enantiomers, 1043vincristine, glutamate effects on, 410
Neurotrophic factor, glial cell-line derived,functional effects, in rat striatum,1181
Newborns, see NeonatesNichols, D. E., see Li, Q., 1261Nicklas, W. J., see Zeevalk, G. D., 332Nicolodi, M., see Ghelardini, C., 884
Nicora, R., see Fox, A. W., 686Nicorandil, inotropic and coronary vasodi-
latory actions, in human tissue,1220
Nicotine, acute withdrawal, transdermalnicotine and, 450
Nicotinic receptorsagonist RJR-2403
in vitro characterization, 1413in vivo characterization, 1422
hippocampal, mapping, 1491melatonin modulation of, in rat vas do-
ferens, 18Nieves, A. L., see Woodward, D. F., 137Nigam, R., Anderson, D. J., Lee, S.-F. and
Bennett, B. M.: Isoform-specificbiotransformation of glyceryltrinitrate by rat aortic glutathi-one S-transferases, 1527
Niinuma, K., see Yamada, T., 1357Nishida, A., see Shimizu, M., 1551Nitric oxide
and cholecystokinin mechanisms of ac-tion, in canine GI tract, 306
generation by proximal tubules, 91-mediated vasodilation, inhibition by li-
popolysaccharide, 918-tissue-type plasminogen activator, pro-
tective effects against myocardialischemia/reperfusion injury, incats, 1174
Nitric oxide synthaseglutamate-activated pathway, inhibi-
tion by lubeluzole, 759inducible, vascular expression, and K�
channel activation, 1514Nitroso aromatic compounds, pyruvate do-
hydrogenase complex-catalyzedformation of N-arylacetohydrox-amic acid from, in rat, 1282
NK, see NeurokininNMDA, see N-Methyl-D-aspartateNNC 14-0185, tolerance and dependence
liability, in mice seizure models,573
NNC 14-0189, tolerance and dependenceliability, in mice seizure models,573
Nock, B., see Cicero, T. J., 767Noda, J., Otagiri, M., Akaike, T. and
Maeda, H.: Pharmacological ad-vantages of conjugation of Cu,Zn-superoxide dismutase with succi-nylated keratin fragment:Improvement ofbiological proper-ties and resistance to oxidativedamage, 162
Nomeir, A. A., Markham, P., Burka, L. T.,Griffin, R. J. and Ghanayem, B.I.: Species differences in the dis-position and metabolism of nali-dixic acid, 222
Nomura, Y., Asano, M., Ito, K., Uyama, Y.,Imaizumi, Y. and Watanabe, M.:Superficial sarcoplasmic reticu-lum calcium buffering of resting,voltage-dependent, Ca� � influxin rat femoral arterial smoothmuscle, 830
Norepinephnne, combined with Re 20-1724, treatment for endotoxemia,in rats, 1197
Normorphinone, N-cyclobutylmethyl ana-log binding and analgesia, 539
Nossuli, T. 0., see Delyani, J. A., 1174Nucleus reticularis gigantocellularis, an-
giotensin-alpha-2 receptor inter-actions, in rat, 795
Oberto, A., Marks, N., Evans, H. L. andGuidotti, A.: Lead (Pb�) pro-motes apoptosis in newborn ratcerebella neurons: Pathologicalimplications, 435
Ochratoxin A, hepatocellular transport,1507
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine, apoptosis induc-tion by, in HL-60 cells, 956
Octreotide, tissue distribution and biliaryexcretion mechanism, 1357
O’Dell, L. B., see Baker, D. A., 392OGAT, see O6-Alkylguanine DNA alkyl-
transferaseOhkubo, Y., see Yamazaki, M., 1157Ohlstein, E. H., see Barone, F. C., 948Ohno, H., see Yoshioka, T., 1282Ohta, K., see Kim, S., 983Ohtaki, T., see Masuda, V., 675Ojala, P., see Kukkonen, J. P., 593Oka, Y., see Sawai, K., 284Okabe, S., see Takahashi, S., 975Okamura, H., see Matsumoto, S., 402Oker-Blom, C., see Kukkonen, J. P., 593Okudaira, H., see Kaminuma, 0., 240Oligonucleotides, renal disposition, in rat,
284Olnes, M. J., Verma, M. and Kurl, R. N.:
2,3,7,8-Tetrachlorodibenzo-p-di-oxin modulates expression of theprostaglandin G/H synthase-2gene in rat thymocytes, 1566
Omar, R. F., see Harvie, P., 1009
Onishi, K., see Abe, Y., 47Onodera, K., see Ito, C., 271
1996 Index 1603
Ontogeny, female-dominant sulfotrans-ferase, in rat liver, 386
Ooboshi, H., see Taguchi, H., 1514Opioid receptors
blockade by cloccinamox, 23delta
agonist effects on butorphanol dis-crimination, 1130
agonist TAN-67 effects on morphine-induced place preference, in mice,177
inhalation exposure, antinociceptive ef-fects, in mice, 69
kappaagonist effects on butorphanol dis-
crimination, 1130agonist effects on diuresis, in rats,
1379mu
agonist effects on butorphanol dis-crimination, 1130
N-CPM-TAMO antagonism, 539
N-CPM-TAMO agomsm, 539
splenocyte density, morphine and meth-adone effects on, in mouse, 172
Opioidscocaine interactions, 524methoclocinnainox, agonist and antago-
nist effects, in rhesus monkeys,
934and �9-THC combined with morphine,
in spinal cord, 608Organic cations, basolateral transport sys-
tem, in rabbit kidney proximal tu-bules, 1086
Orlando, L., see Lacal, P. M., 416; Prete, S.P., 1574
O’Reurke, R., see Fox, A. W., 686O’Shea, D., see Kim, R. B., 4Otagiri, M., see Noda, J., 162Otsuki, M., see Tachibana, I., 1404
Ottoboni, C., see Debernardis, D., 84Ovarian cancer, effects of endogenous
TNF in, 84OVCAR-8 cells, effects ofendogenous TNF
secreted by, 84Owan, I., see Sate, M., 298Oxazepam, anticonvulsant effects, in di-
rect cortical stimulation model,803
Oxcarbazepine, teratogenicity, in SWV
mouse, 1237Oxygen consumption, myocardial, levosi-
mendan effects on, 120Oz, M., see Brauneis, U., 1063
p38 kinase, inhibitor SB 203580, pharma-cological profile, in animal mod-els, 1453
Packer, M., see Todaka, K., 120Pain, neuropathic, SNX-lll spinal antino-
ciception in, in rat models, 1243PALCAR, see Palmitoyl-L-carnitine
Palmitoyl-L-carnitine, mechanical de-rangement induced by, dilazepand K-7259 effects on, in ratheart, 32
Pancetti, F. C., see Aguayo, L. G., 1116Pancreas, function, TP-680 effects on,
1404Papillary muscle, left ventricular,
mechano-energetic effects of cm-
makalim on, in guinea pig, 464
Pappano, A. J., see Shirayama, T., 1274Paraquat, renal transport, in LLC-PK1
cells, 625
Pardridge, W. M., see Wu, D., 77Panetal cells, H� secretion in, modulation
by PKC, in rabbit, 97Park, J. E., see Wilson, S., 214Parodi, S., see Debernardis, D., 84Parolaro, D., see Patrini, G., 172Passanil, M. B., see Pugliese, A. M., 1100Pasternak, G. W., see Kolesnikov, V. A.,
502Patch, nicotine, and acute nicotine with-
drawal, 450Patrii, G., Massi, P., Ricevuti, G., Maz-
zone, A., Fossati, G., Mazzucch-elli, I., Gori, E. and Parolaro, D.:Changes in opioid receptor den-sity on murine splenocytes in-duced by in vivo treatment withmorphine and methadone, 172
Payne, A., see Soulard, C. D., 1379Payne, N. A., see Gerber, J. G., 718PBMCs, see Peripheral blood mononuclear
cellsPCP, see PhencycidinePD098059, and serotonin activation of
MAPK, in vascular smooth mus-cle, 1541
Peck, A. B., see Bowman, M. A., 790Peeters, L., see Lesage, A. S., 759Pentagastrin, gastric acid secretion re-
sponse, inhibition by secretin, incanine, 718
Peoples, R. W., see Brauneis, U., 1063Pepeu, G., see Pugliese, A. M., 1100Peptide, blood-brain barrier drug delivery,
CNS effects, in rats, 77Pereira, E. F. R., see Alkondon, M., 1491Peripheral blood mononuclear cells, IL-S
suppression by T-440 in, 240Peripheral morphine analgesia, 502Peroxidative stress, cocaine-induced, in
rat liver, 359Perrault, G., see Itier, V., 1092Pertussis toxin, effects in morphine and
13-endorphin antinociception, inmouse, 39
PET, see Positron emission tomographyPeters, C., see Widness, J. A., 1205Peters, see Lippiello, P. M., 1422Peters, T. S. and Lewis, S. J.: Lipopolysac-
charide inhibits acetylcholine-and nitric oxide-mediated vasodi-lation in vivo, 918
Pettus, M., see Bowersox, S. S., 1243
Petzinger, B., see Kontaxi, M., 1507Phencyclidine, prepulse inhibition disrup-
tion, seroquel effects on, in rats,1290
Phenobarbital, neonatal exposure, im-printed overinduction of CYP2B1and 2B2 after, in adult rats, 991
(E)-3-(2-Phenyl-2-carboxyethenyl)-4,6-dichloro-1H-indole-2-carboxylicacid, see [3H]MDL 105,519
Phenylethanolamine N-methyltrans-ferase, gene regulation, and Egr-1mRNA expression, in rat adrenalgland, 379
Phorbol estereffects on parietal cell function, in rat>
bit, 97effects on superoxide generation in
HL-60 cells, 633Phosphatase, effects on superoxide gener-
ation in HL-60 cells, 633Phosphodiesterase inhibitors
modulation ofmyocardial TNF-a by, 247T-440, IL-S suppression by, in PBMCs,
240type N, Re 20-1724, for endotoxemia, in
rats, 1197Phospholipase A�, effects on superoxide
generation in HL-60 cells, 633Picker, M. J., Benyas, S., Horwitz, J. A.,
Thompson, K., Mathewson, C.and Smith, M. A.: Discriminativestimulus effects of butorphanol:Influence of training dose on thesubstitution patterns producedby mu, kappa and delta opioidagonists, 1130
Pickworth, W. B., Fant, R. V., Butschky,M. F. and Henningfield, J. E.: Ef-fects of transdermal nicotine do-livery on measures of acute nice-tine withdrawal, 450
Piercey, M. F., see Merchant, K. M., 1392Piletz, J. E., Thu, H. and Chikkala, D. N.:
Comparison of ligand binding aS-finities at human I1-imidazolinebinding sites and the high affinitystate of alpha-2 adrenoceptorsubtypes, 694
Pindel, E. V., see Kamendulis, L. M., 713Pituitary gland, CRF and CRF-Rl mRNA
levels after binge cocaine admin-istration, in rat, 351
Place preferencecocaine-induced, intra-accumbens
sulpiride and, 392morphine-induced, TAN-67 effects on, in
mice, 177Plasma cocaine, arterial and venous con-
centrations, 1345Plasmid delivery, efficiency after lipid-
mediated gene transfer, 1462Plasminogen activators
antibody-conjugated, targeting to pul-monary vasculature, 1026
S-nitrosylated tissuo-type, protective ef-fects against myocardial isch-emia/reperfusion injury, in cats,1174
Platelet-activating factor, contractile ef-
fects, during ileal inflammation,207
Platelets, imidazoline binding sites, 694PNMT, see Phenylethanolamine N-meth-
yltransferasePogun, S., see Fleckenstein, A. E., 200Porreca, F., see Schetz, J. A., 1069Positron emission tomography
cerebral BMS-181101 pharmacokineticsby, 325
of ziprasidone and 5�’F2 receptors, 939Potassium channels
activation, NO-synthase expressionand, 1514
Ca � k-activated, w-agatoxin-IVA andw-conotoxin-MVIIC effects on, inmouse motor nerve terminals,1229
endothelin receptor coupling, in rat pul-
monary arterial myocytes, 1053free radical effects on, in non-neurogenic
relaxation, in canine airway mus-cle, 813
Kvl.2 clone, quiidine effects on, 844Kv4.2 clone, blockade by 4-aminopyri-
dine, 865
1604 Index Vol. 279
mAChR-operated, inhibition by amioda-rone, in guinea pig atrial cells,617
slow delayed rectifier, blockade by quin-idine, 856
Potassium-ATP channel openers, nicoran-di!, inotropic and coronary vase-dilatory actions, 1220
Prepulse inhibition, disruption by phen-cycidine, seroquel effects on, inrats, 1290
Preston, K. L., see Walsh, S. L., 524Prete, S. P., Aquino, A., Masci, G., Or-
lando, L., Giuliani, A., De Santis,S., De Vecchis, L., De Filippi, R.,Greiner, J. W., Bonmassar, E.and Graziani, G.: Drug-inducedchanges of carcinoembryonic an-tigen expression in human cancercells: Effect of 5-fluorouracil,1574
Proksch, J. W., see Traylor, L. A., 91Propranolol, effects on survival in stroke-
prone spontaneously hyperten-sive rats, 948
Prostacyclin, bradykinin response, ACEinhibitor effects on, 703
Prostaglandin D2 receptors, effects inprostanoid-induced conjunctivalpruritus, 137
Prostaglandin E2 receptors, effects inprostanoid-induced conjunctival
pruritus, 137Prostaglandin G/H synthase-2, gene ex-
pression, in rat thymocytes, 1566
Prostaglandin 12mediation by enteric nerves, in piglet
cryptosporidiosis, 1109receptor effects in prostanoid-induced
conjunctival pruritus, 137Prostaglandins, pruritogenic, 137Prostanoids, TP receptors, in human non-
pregnant myometrium, 262Protamine, catecholamine secretion and
ion channel inhibition by, in ho-vine adrenal medullary cells, 838
Protein kinase Ceffects on superoxide generation in
HL-60 cells, 633in flow-induced contraction, 668modulation ofW secretion by, in rabbit
parietal cells, 97Protein serine-threonine phosphatase 1,
effects on superoxide generationin HL-60 cells, 633
Protein serine-threonine phosphatase 2a,effects on superoxide generationin HL-60 cells, 633
Protein tyrosine phosphatase, effects onsuperoxide generation in HL-60cells, 633
Proteinsmitogen-activated, kinase activation by
serotonin, in vascular smoothmuscle, 1541
tetra-a-helix-bundle, halothane binding,56
Proteinuria, tenidap-induced, rat model,1318
Proximal tubulesbasolateral organic cation transport sys-
tom, in rabbit, 1086nitric oxide generation by, 91
Pruritogenic prostaglandins, 137
Pruritus, conjunctival, ketorolac effectsagainst, 137
Pugh, G., Jr., Smith, P. B., Dombrowski,D. S. and Welch, S. P.: The role ofendogenous opioids in enhancingthe antinociception produced bythe combination of i�”-tetrahydro-cannabinol and morphine in thespinal cord, 608
Pugliese, A. M., Passanil, M. B., Pepeu, G.and Corradetti, R.: Felbamate do-creases synaptic transmission inthe CAl region of the rat hip-pocampal slices, 1100
Pulmonary arterial myocytes, endothelinreceptor coupling to potassiumand chloride channels in, in rat,1053
Pulmonary stretch receptors, inhibitoryeffects of CO2 inhalation on, inrabbit, 402
Pulmonary vasculature, antibody-conju-gated plasminogen activator tar-geting to, 1026
Pyruvate dehydrogenase complex, -cata-lyzed formation of N-arylacetohy-droxamic acid, in rat, 1282
Quaternized ellipticines, accumulation byhuman tumor cells, 1018
Querl, I. U., see Hohage, H., 1086N-(2-Quindinoethyl)-5-isoquinoline sul-
fonamide, effects on parietal cellfunction, in rabbit, 97
QuinidineKvl.2 effects, 844slow delayed rectifier potassium chan-
nel blockade by, 856Quinine, 3-hydroxylation by cytochrome
P450 isoforms, in liver, 1327
Rabanal, F., see Johansson, J. S., 56Raje, R. R., see Ray, S. D., 1470Raloxiuene, comparison with alendronate
and estrogen, in rats, 298Rathbone, D., see Bristow, L. J., 492Rauch, S. L., see Fischman, A. J., 939Ravel, D., see Desta, B., 1077Ray, S. D., Mumaw, V. R., Raje, R. R. and
Fariss, M. W.: Protection of acet-aminophen-induced hepatocellu-lar apoptosis and necrosis by cho-lesteryl hemisuccinatepretreatment, 1470
RBC, see Red blood cellsReceptors
adenosine A3, bronchospasm inducedby, in BDE rats, 1148
adenosine A1, 8-butylaminoadenosinepartial agonism at, 1439
adrenergic
alpha-2, angiotensin receptor interac-tions, 795
alpha-2, in ethanol-clonidine interac-tions, in rats, 443
alpha-2, rostral ventrolateral medul-lary blockade, and cocaine sym-pathoinhibition, 967
beta-3 agonist potency, receptor den-sity and, 214
angiotensin, alpha-2 adrenoceptor in-teractions, 795
benzodiazepine, ligands, in mice seizure
models, 561, 573cholecystokinin, antagonist TP-680,
pharmacological profile, 1404
corticotropin-releasing factor, type 1,mRNA levels after binge cocaineadministration, 351
cytokine, soluble, as carrier proteins,340
dopamineagonist effects on eye blink rate, in
cynomolgus monkeys, 1211antagonist effects on METH-induced
histamine release, in rat stria-tum, 271
ganglionic inhibition by, in canine car-diac sympathetic gangia, 822
dopamine D4, antagonist U-l0l387,pharmacological characteriza-tion, 1392
endothelin, potassium and chloridechannel coupling, in rat pulmo-nary arterial myocytes, 1053
endothelinA, antagonism by TAK-044,675
endothelinB, antagonism by TAK-044,675
GABA, agonist renal effects, in rat, 602GABAA
in benzodiazepine-tolerant rats, 1092
hippocampal, mapping, 1491insecticides and, in cerebellar granule
neurons, 1191
stanozolol effects on, 186glycine
antagonist L-70l,324, behavioral pro-file, 492
[3HIMDL 105,519 site, 62potentiation by ethanol, in mouse spi-
nal neurons, 1116
5�”�1A’ desensitization by chronic flu-oxetine, 1035
5-HT2, ziprasidone and, PET analysis,939
5-HT3, antagonist granisetron, delayedemesis by, in piglet, 255
5-HT7, chronic antidepressants and, inrat frontocortical astrocytes, 1551
IL-4, soluble, effects on murine IL-4pharmacokinetics, 340
imidazoline, platelet binding sites, 694muscarinic
aceclidine enantiomer interactions,1335
allosteric lead structures for, 926Hml, Hm3 and HmS, functional prop-
erties, 593-operated potassium currents, inhibi-
tion by amiodarone, 617neurokinin NK-1INK-2 antagonist MDL
105,212 effects in allergic re-sponse, in guinea pig model, 732
neurokinin NK-2, in dog urinary blad-der, 423
nicotiicagonist RJR-2403, in vitro character-
ization, 1413agonist EJR-2403, in vivo character-
ization, 1422hippocampal, mapping, 1491melatonin modulation of, in rat vas
deferens, 18NMDA
antagonist L-701,324, behavioral pro-ifie, 492
[3H]MDL 105,519-glycine site, 62inhibition by dynorphin, 1063inhibition by haloperidol, 154
1996 Index 1605
modulation by lead, in rat hippocam-pal neurons, 143
recombinant human subtypesNMDAR1A/2A and NMDAR1A/2B, in mammalian cells, 367
subunit-transfected CHO cells, ac-quired excitotoxicity in, 515
opioidblockade by cloccinamox, 23delta, agonist effects on butorphanol
discrimination, 1130delta, agonist TAN-67 effects on mor-
phine-induced place preference,in mice, 177
inhalation exposure, antinociceptiveeffects, in mice, 69
kappa, agonist effects on butorphanoldiscrimination, 1130
kappa, agonist effects on diuresis, inrats, 1379
methoclocinnamox agonist and antag-onist effects, in rhesus monkeys,934
mu, agonist effects on butorphanoldiscrimination, 1130
mu, N-CPM-TAMO antagonism, 539N-CPM-TAMO agonism, 539splenocyte density, morphine and
methadone effects on, in mouse,172
prostaglandin D2 effects in prostanoid-induced conjunctival pruritus,137
prostaglandin E2, effects in prostanoid-induced conjunctival pruritus,137
prostaglandin ‘2, effects in prostanoid-induced conjunctival pruritus,137
pulmonary stretch, inhibitory effects ofCO2 inhalation on, in rabbit, 402
scavenger, effects in renal oligonucleo-tide disposition, in rat, 284
secretin, VIP specificity, in rat, 55501, agonist SA4503, enhancement of
acetylcholine release by, in ratbrain, 106
soluble cytokine, as carrier proteins, 340soluble IL-4, effects on murine IL-4
pharmacokinetics, 340tachykinin, in dog urinary bladder, 423thrombin, activation in vivo, cardiovas-
cular effects of, 1365thromboxane A�, regulation by testos-
terone 5a-reductase, 1386TP, in human nonpregnant myome-
trium, 262
Red blood cells, injured, adenosine deami-nase release by, 1250
Reeves, L., see Bencherif, M., 1413Relaxation, see also Vasodilation
non-neurogenic, in canine airway mus-cle, 813
Renal cortex, dicarboxylate carrier, flue-rescein interactions, in rat mito-chondria, 1559
Renal damage, carvedilol effects on, instroke-prone spontaneously hy-pertensive rats, 948
Renal failure, in endotoxemia, norepi-nephrine combined with Re 20-1724 treatment, in rats, 1197
Renal proximal tubulesbasolateral organic cation transport sys-
tem, in rabbit, 1086
nitric oxide generation by, 91Reperfusion injury
arrhythmias, Re 22-9194 effects on, indogs, 877
NO-tPA effects against, in cats, 1174proarrhythmic effects offlecainide in, in
tissue model, 317Repolarization, delayed, rhythm anoma-
lies related to, 231
Reproductive tissues, long-term effects ofraloxifene vs alendronate or es-trogen on, in rats, 298
Reverse transcriptase, HN, inhibition bycalanolide A, 652
Reward, morphine, TAN-67 effects on, inmice, 177
Rhoads, J. M., see Argenzio, R. A., 1109Rhythm anomalies, related to delayed re-
polarization, 231Ribavirin, combined with 2’,3’-dideoxyi-
nosine, in murine AIDS model,1009
Ricaurte, G., see Sparago, M., 1043Rice, K., see Schetz, J. A., 1069Ricevuti, G., see Patrini, G., 172Rifabutin, disposition and metabolism by
liver, in rats, 1300Rios, C. D., see Taguchi, H., 1514RJR-2403
in vitro characterization, 1413in vivo characterization, 1422
RNA, see Messenger RNARo 20-1724, for endotoxemia, in rats,
1197Re 22-9194, and ventricular fibrillation,
in dogs, 877Reberts, M. S., see Singh, P., 908Remain, D., see Gr#{233}lot,L., 255Rostral ventrolateral medulla, alpha-2 re-
ceptor blockade in, and cocainesympathoinhibition, 967
RTI-76, intrastriatal, dopamine trans-porter inactivation by, 200
Rubin, R. H., see Fischman, A. J., 939Ruediger, B., see Christian, B. T., 325Rundfeldt, C., see Loscher, W., 561Rundfeldt, C., see Loscher, W., 573Ruppel, J., see Fox, J. A., 1000
Russel, F. G. M., see Masereeuw, R., 1559Russo, P., see Debernardis, D., 84Ryder, D., see Brown, N. J., 703
SA4503, enhancement of acetylcholine re-lease by, in rat brain, 106
Sakurai, B., see Ito, C., 271Salazar, D. E., see Christian, B. T., 325Saleh, J. L., see Slotkin, T. A., 478Saleming, W. C., see Masereeuw, R., 1559Salter, K. J. and Kozlowski, R. Z.: Endo-
thelin receptor coupling to potas-sium and chloride channels in iso-
lated rat pulmonary arterialmyocytes, 1053
Sanders, M. J., see Aleo, M. D., 1318Sarcolemma, Ca� � entry and intracellular
overload, effects in torsades depointes, 231
Sarcoplasmic reticulum, calcium bufferingaction of, in rat femoral arterialsmooth muscle, 830
Sarna, S. K., see Jou#{235}t,P., 207Sata, T., see Minami, K., 838Sato, M., see Ito, C., 271Sate, M., Bryant, H. U., Iversen, P., Hel-
terbrand, J., Smietana, F., Bemis,K., Higgs, R., Turner, C. H.,
Owan, I., Takano, Y. and Burr, D.B.: Advantages of raloxifene overalendronate or estrogen on nonre-productive and reproductive tis-sues in the long-term dosing ofovariectomized rats, 298
Satoh, M., see Masuda, Y., 675Sawai, K., Mahato, R. I., Oka, Y.,
Takakura, V. and Hashida, M.:Disposition of oligonucleotides inisolated perfused rat kidney: In-volvement of scavenger receptorsin their renal uptake, 284
Saywell, K. L., see Bristow, L. J., 492SB 203580, pharmacological profile, in an-
imal models, 1453Scalia, R., see Delyani, J. A., 1174Scatton, B., see Itier, V., 1092Scavenger receptors, effects in renal oligo-
nucleotide disposition, in rat, 284Schetz, J. A., Calderon, S. N., Bertha, C.
M., Rice, K. and Porreca, F.:Rapid in vivo metabolism of amethylether derivative of (±)-
BW373U86: The metabolic fate of[3H]SNC121 in rats, 1069
Schmidt, R. L., see Widness, J. A., 1205Schoenhoff, M. B., see Fox, J. A., 1000Schreur, P. J. K. D., see Merchant, K. M.,
1392Schultz, D., see Desta, B., 1077Schwinger, R. H. G., see M#{252}ller-Ehmsen,
J., 1220Seale, J. P., see Chan, B. S. H., 625Sealey, J. E., see Barone, F. C., 948Secretin, gastric histamine release modu-
lation by, in canine, 718Secretin receptors, VIP specificity, in rat,
555Segawa, K., see Minami, K., 838Seidler, F. J., see Slotkin, T. A., 478Seizures, benzodiazepine receptor ligands
in, in mice models, 561, 573Sekioka, K., see Abe, Y., 47Selegiline, see L-DeprenylSenchyna, M. and Crankshaw, D. J.: Char-
acterization of the prostanoid TPreceptor population in humannonpregnant myometrium, 262
Sensitivity, dynorphin, to NMDA recep-tors, 1063
Sensorimotor gating, seroquel effects on,in PCP-treated rats, 1290
Seroquel, effects in PCP-treated rats, 1290Serotonin, see 5-Hydroxytryptamine
Serum lactate, reduction by sodium di-chloroacetate, 686
Sethy, V. H., see Merchant, K. M., 1392Sex
and cocaine immunotoxicity, in B6C3F1and DBA/2 mice, 3
differences in morphine antinociception,767
Seyed-Mozaffari, A., see Xu, J. Y., 539Sf9 cells, muscarinic receptor subtypes
functional properties, 593Shapiro, B. H., see Agrawal, A. K., 991Sharp, T., see Gartside, S. E., 277Shaw, W., see Bebok, Z., 1462Shenfield, G. M., see Boyle, F. M., 410Shigematsu, A., see Minami, K., 838Shimada, T., see Kim, R. B., 4Shimizu, M., Nishida, A., Zensho, H. and
Yamawaki, S.: Chronic antide-pressant exposure enhances
1606 Index Vol. 279
S-Hydroxytryptamine7 receptor-mediated cyclic adenosine mono-phosphate accumulation in ratfrontocortical astrocytes, 1551
Shimizu, T., see Matsumoto, S., 402Shinkawa, T., see Kim, S., 983Shirayama, T. and Pappano, A. J.: Bipha-
sic effects of intrapipette cyclicguanosine monophosphate on L-type calcium current and contrac-tion of guinea pig ventricularmyocytes, 1274
Shock, endotoxin, antiarthritic effects ofSB 203580 on, in animal models,1453
Shoup, T. M., see Fisckman, A. J., 939Shyr, M.-H., see Yang, C.-H., 795Sicuteri, F., see Ghelardini, C., 884
Siddall, B. J., see Morita, K., 379Siegel, B. W., see Baron, B. M., 62U1 receptors, agonist SA4SO3, enhance-
ment of acetylcholine release by,in rat brain, 106
Silibinin, effects on fibronectin turnover,in mesangial cells, 1520
Simard, M., see Harvie, P., 1009
Simell, 0. G., see Bowman, M. A., 790
Simon, W. C., Anderson, D. J. and Ben-nett, B. M.: Inhibition ofthe phar-macological actions of glyceryltrinitrate after the electroporeticdelivery of a glutathione S-trans-ferase inhibitor, 1535
Sin, J.-I. and Specter, S.: The role of inter-feron-gamma in antiretroviral ac-tivity of methionine enkephalinand AZT in a murine cell culture,1268
Singh, P. and Reberts, M. S.: Local deeptissue penetration of compoundsafter dermal application: Struc-ture-tissue penetration relation-ships, 908
Singh, T., see Bowersox, S. S., 1243Skidgel, R. A., see Deddish, P. A., 1582Skiles, G. L., see Bennett, G. D., 1237Skvoretz, R., see Varney, M. A., 367Slattery, J. T., see Bennett, G. D., 1237Slotkin, T. A., Thai, L., McCook, C., Saleh,
J. L., Zhang, J. and Seidler, F. J.:Aging and glucocorticoids: Effectson cell signaling mediatedthrough adenylyl cyclase, 478
Slowly adapting pulmonary stretch recep-tors, inhibitory effects of CO2 in-halation on, in rabbit, 402
Smietana, F., see Sate, M., 298Smith, M. A., see Picker, M. J., 1130Smith, M. W., see Merchant, K. M., 1392Smith, P. B., see Pugh, G., Jr., 608
Smooth musclefemoral arterial, sarcoplasmic reticulum
calcium buffering action in, inrat, 830
tracheal, cholinergic nerve-mediatedcontractions, ET-1 effects on, inrat, 1142
vascular, mitogen-activated protein ki-nase activation by serotonin in,1541
[3H]SNC121, metabolic fate, in rats, 1069Snell, L. D., Szab#{243},G., Tabakoff, B. and
Hoffman, P. L.: Gangliosides re-
duce the development of ethanol
dependence without affecting eth-anol tolerance, 128
SNX-l11, spinal antinociceptive effects, inrat neuropathic pain, 1243
SOD, see Superoxide dismutaseSodium dichloroacetate, serum lactate re-
duction by, 686
Solutes, structure and penetration, 908
Somatosensory-evoked discharges, co-caine-induced enhancement of,
substrates of, in rat barrel fieldcortical neurons, 582
Soose, M., see Wenzel, S., 1520Sorscher, E. J., see Bebok, Z., 1462Soudijn, W., see MathSt, R. A. A., 1439Soulard, C. D., Guerif, S., Payne, A. and
Dahi, S. G.: Differential effects offedotozine compared to other scagonists on diuresis in rats, 1379
Spangler, R., see Thou, Y., 351Sparago, M., Wios, J., Yuan, J., Hatzidimi-
triou, G., Tolliver, J., Dal Cason,T. A., Katz, J. and Ricaurte, G.:Neurotoxic and pharmacologicstudies on enantiomers of the N-methylated analog of cathinone(methcathinone): A new drug ofabuse, 1043
Species differences, in nalidixic acid me-
tabolism, 222Specter, S., see Sin, J.-I., 1268
Spetie, D., see Koudriakova, T., 1300Spinal antinociception, SNX-lll, in rat
neuropathic pain, 1243
Spinal cord, dynorphins and combined �
THC and morphine in, 608Spinal neurons, glycine receptor potentia-
tion by ethanol in, in mouse, 1116Splenocytes, opioid receptor density, mor-
phine and methadone effects on,in mouse, 172
Spontaneous hypertensionangiotensin II effects on renal cAMP re-
lease in, in rat, 114carvedilol effects on survival in, in
stroke-prone rats, 948effects of diuretics on cardiac hypertro-
phy in, in rats, 983Stall, S., see Li, Q., 1261Stamatakos, C., see Mussap, C. J., 423Stanozolol
effects on GABAA receptor function, 186liver microsome binding site, in male
rat, 1123Stanulis, E. D., see Matulka, R. A., 3Stanzione, S., see Debernardis, D., 84
Stennett, R., see TOdaka, K., 120Steroids
gonadal, vascular effects, 1stanozolol
effects on GABAA receptor function,186
liver microsome binding site, in malerat, 1123
Stieger, B., see Kontaxi, M., 1507Stolte, H., see Wenzel, S., 1520Stoltz, R. R., see Fox, A. W., 686
Stomachgastric acid secretion
inhibition by secretin, in canine, 718TP-680 effects on, 1404
gastric mucosa, leminoprazole cytopro-tection in, in rabbit, 975
H� secretion, modulation by PKC, inrabbit parietal cells, 97
histamine release, modulation by secre-tin, in canine, 718
Stressmetabolic, hypothermia and neuropro-
tection against, 332peroxidative, cocaine-induced, in rat
liver, 359Stroke
lubeluzole neuroprotective effects in, inrat photochemical model, 748
-prone spontaneously hypertensive rats,carvedilol effects on survival in,948
Struble, C., see Fox, J. A., 1000
Su, M.-T., see Hsu, K.-S., 740Substance P(l-7), effects on morphine tel-
erance and dependence, 662Succinylated keratin fragment, SOD con-
jugate, effects, 162Sugai, N., see Matsumoto, S., 402Sugiyama, Y., see Yamada, T., 1357Sugo, T., see Masuda, Y., 675Suko, M., see Kaminuma, 0., 240Sulfotransferases, female-dominant, on-
togeny and hormonal basis, in ratliver, 386
Sullivan, B. W., see Fox, A. W., 686Sullivan, J. T., see Walsh, S. L., 524Sulpiride, intra-accumbens, effects on co-
caine-induced locomotion andconditioned place preference, 392
Sumatriptan, antinociception, in rodentsand guinea pigs, 884
Sung, C.-H., see Winkler, J. D., 956Superoxide, generation in HL-60 cells, 633Superoxide dismutase, succinylated kera-
tin fragment conjugate, effects,162
Surette, M. E., see Winkler, J. D., 956Suzuki, K., see Matsumoto, S., 402Suzuki, T., see Masubuchi, Y., 724Suzuki, T., Tsuji, M., Mori, T., Misawa, M.,
Endoh, T. and Nagase, H.: Effectof the highly selective and non-peptide 8 opioid receptor agonistTAN-67 on the morphine-inducedplace preference in mice, 177
Svensson, K. A., see Merchant, K. M., 1392SW626 cells, effects of endogenous TNF
secreted by, 84Swanson, K. L., see Marchioro, M., 143Swerdlow, N. R., Bakshi, V. and Geyer, M.
A.: Seroquel restores sensorimo-tor gating in phencyclidine-treated rats, 1290
Sympathoinhibition
cocaine, blockade by rostral ventrolat-eral medullary alpha-2 receptor,967
dopamine receptor, in canine heart, 822Synaptic transmission, decrease by fel-
bamate, in CAl rat hippocampalslices, 1100
Synthetic proteins, halothane binding, 56Szab#{243},G., see Snell, L. D., 128
T-440, IL-S suppression by, in PBMCs, 240Tabakoff, B., see Snell, L. D., 128Tachibana, I., Kanagawa, K., Yamamoto,
Y. and Otsuki, M.: Pharmacolog-ical profile of a new serine deriv-ative, the cholecystokinin recep-tor antagonist TP-680, onpancreatic, biliary and gastricfunction, 1404
1996 Index 1607
Van De Kar, L. D., see Li, Q., 1035
Tachykinin receptors, in dog urinary blad-der, 423
Taguchi, H., Heistad, D. D, Chu, Y., Bios,C. D., Ooboshi, H. and Faraci, F.M.: Vascular expression of induc-ible nitric oxide synthase is asso-ciated with activation of Ca� �-
dependent K� channels, 1514TAK-044, endothelin receptor binding and
antagonist properties, 675Takahashi, S. and Okabe, S.: The cytopro-
tective effect of leminoprazole onindomethacin-induced damage torabbit gastric mucosal cells, 975
Takakura, Y., see Sawai, K., 284Takano, Y., see Sato, M., 298Tamagawa, M., see Watanabe, Y., 617TAN-67, effects on morphine-induced
place preference, in mice, 177Tan, P. P. C., see Yang, C.-H., 795Tang, A. H., see Merchant, K. M., 1392Tapia, J. C., see Aguayo, L. G., 1116[355] TBPS, see [355] t-Butylbicyclophos-
phorothionateTenbrink, R. E., see Merchant, K. M., 1392Temdap proteinuria, rat model, 1318Terasaki, T., see Yamada, T., 1357Teratogenicity, carbamazepine-l0,l 1-
epoxide and oxcarbazepine, inSWV mouse, 1237
Testosterone Sa-reductase, regulation ofthromboxane A2 receptors by,1386
2,3,7,8-Tetrachlorodibenze-p-dioxin, pros-taglandin G/H synthase-2 geneexpression and, in rat thymo-cytes, 1566
12-O-Tetradecanoylphorbol-13-acetate, ef-fects on parietal cell function, inrabbit, 97
Tetraethylammonium, tubular transport,in rabbit, 1086
Tetra-a-helix-bundle proteins, halothanebinding, 56
i�9-Tetrahydrocannabinol, combined withmorphine, dynorphins and, in spi-nal cord, 608
Tetrandrine, effects on acetylcholine re-lease, in mouse neuromuscularjunction, 891
Thai, L., see Slotkin, T. A., 478THC, see �9-TetrahydrocannabinolThiazide, effects on cardiac hypertrophy,
in spontaneously hypertensiverats, 983
Thiopental, systemic and cerebral kinet-ics, enantiomeric analysis insheep, 291
Thomas, G., see Delyani, J. A., 1174Thomas, N. J., see Carcillo, J. A., 1197Thompson, K., see Picker, M. J., 1130Thompson, T., see Koudriakova, T., 1300Thorn, L., see Bristow, L. J., 492Thrombin receptors, activation in vivo,
cardiovascular effects of, 1365
Thromboxane A� receptors, regulation bytestosterone 5a-reductase, 1386
Thromboxane A� synthase, inhibition byRe 22-9194, in dogs, 877
Thymocytes, prostaglandin G/H syn-thase-2 genes expression in, inrats, 1566
Tissueoctreotide distribution mechanism, 1357
structure-tissue penetration relation-ships, 908
Tissue-type plasminogen activator, S-nitrosylated, protective effectsagainst myocardial ischemia/reperfusion injury, in cats, 1174
Tizanidine, platelet I� binding sites, 694TNF, see Tumor necrosis factorTobacco, see NicotineTodaka, K., Wang, J., Yi, G.-H., Stennett,
R., Knecht, M., Packer, M. andBurkhoff, D.: Effects of levosi-mendan on myocardial contractil-ity and oxygen consumption, 120
Toleranceacute ethanol, genetic selection for, in
mouse lines, 1310acute morphine, substance P(l-7) effects
on, 662benzodiazepine, GABAA receptors in, in
rats, 1092benzodiazepine receptor ligand liability,
in mice, 561, 573DOI, 782m-CPP, 782morphine, and peripheral morphine an-
algesia, 502Tolliver, J., see Sparago, M., 1043Topical application of compounds, local
deep tissue penetration of, 908Topoisomerase II, inhibitors, activity en-
hancement by endogenous TNF,in ovarian cancer cells, 84
Torsades de pointes, calcium effects in,231
Towers, P., see Baron, B. M., 62Toxicity
acetaminophencholesteryl hemisuccinate protection
against, 1470in male Wistar rats, 548
ammonia, trimethylamine preventiveeffects against, 194
cocainein B6C3F1 and DBA/2 mice, 3in rat liver, 359
1,1-dichioroethylene, in adult and wean-ling mice, 1484
excitotoxicity, acquired, in NMDA re-ceptor subunit-transfected CHOcells, 515
glutamatelubeluzole protective effects against,
759trimethylamine preventive effects
against, 194indomethacin, leminoprazole protection
against, in rabbit gastric mucosalcells, 975
lead, in newborn rat, 435lipid A, nitric oxide effects in, 91vincristine, glutamate effects on, 410
Toxinsw-agatoxin-NA, effects on motor nerve
Ca� � currents, in mouse, 1229brain tumor-selective, 1018w-conotoxin-MVIIC, effects on motor
nerve Ca� � currents, in mouse,1229
ochratoxin A, hepatocellular transport,1507
pertussis, effects in morphine and 13-en-dorphin antinociception, inmouse, 39
TP-680, pharmacological profile, 1404
TP receptors, in human nonpregnant myo-metrium, 262
Tr#{228}nkle,C., Kostenis, E., Burgmer, U. andMohr, K.: Search for lead struc-tures to develop new allostericmodulators of muscariic recep-tors, 926
Transacylase, CoA-independent, inhibi-tors, apoptosis induction by, 956
Transdermal nicotine, and acute nicotinewithdrawal, 450
Traylor, L. A., Proksch, J. W., Beanum, V.C. and Mayeux, P. R.: Nitric oxidegeneration by renal proximal tu-bules: Rele of nitric oxide in thecytotoxicity of lipid A, 91
Tremblay, M., see Harvie, P., 1009Triazene compounds, OGAT inactivation
by, 416Tricklebank, M. D., see Bristow, L. J., 492Trimethylamines, carnitine and choline
derivatives containing, preven-tive effects against ammonia tox-icity and glutamate neurotoxic-ity, 194
Trumper, L., see Monasterolo, L. A., 602Trumper, L., Monasterolo, L. A. and Elfas,
M. M.: Nephrotoxicity of acet-aminophen in male Wistar rats:Rele of hepatically derived me-tabolites, 548
Trybulski, E. J., see Yao, J.-A., 856Tsai, J.-J., see Hsu, K.-S., 740Tseng, G.-N., see Yao, J.-A., 856Tseng, G.-N., Jiang, M. and Yao, J.-A.:
Reverse use dependence of Kv4.2blockade by 4-aminopyridine, 865
Tseng, G.-N., Thu, B., Ling, S. and Yao,J.-A.: Quinidine enhances andsuppresses Kvl.2 from outsideand inside the cell, respectively,844
Tseng, L. F. and Collins, K. A.: Pretreat-ment with pertussis toxin differ-entially modulates morphine-and 13-endorphin-induced antino-ciception in the mouse, 39
Tsuchiya, N., see Kim, S., 983Tsuji, M., see Suzuki, T., 177Tsutsui, M., see Minami, K., 838Tulebaev, S., see Koudriakova, T., 1300Tumor necrosis factor a, myocardial, mod-
ulation by PDE inhibitors, 247Thmor necrosis factor, endogenous, topo II
inhibitor activity enhancementby, in ovarian cancer cells, 84
Tumorsbrain, cytotoxins selective for, 1018metastasis, anti-IL4 effect on, 472
Turner, C. H., see Sate, M., 298
U-101387, pharmacological characteriza-tion, 1392
Ueda, Y., see Abe, Y., 47Uematsu, T., see Yoshioka, T., 1282Ujiie, A., see Murakami, M., 877Ulreich, J. B., see Forkert, P. G., 1484
Ulrich, C. D., see Holtmann, M. H., 555Upton, R. N., see Mather, L. E., 291Urcan, M., see Varney, M. A., 367Urinary bladder, tachykiin NK-2 recep-
tors in, in dog, 423Utkin, I., see Koudriakova, T., 1300Uyama, Y., see Nomura, Y., 830
1608 Index VoL 279
Van de Kar, L. D., see Li, Q., 1261Van der Wenden, E. M., see MathOt, R. A.
A., 1439
Van Home, C. G., see Hebert, M., 1181Van Reet, G., see De Ryck, M., 748Vanhoutte, P. M., see Desta, B., 1077Varner, K. J., see Abrahams, T. P., 967Varney, M. A., Jachec, C., Deal, C., Hess,
S. D., Daggett, L. P., Skvoretz, R.,Urcan, M., Morrison, J. H., Mo-ran, T., Johnson, B. C. and Veli-#{231}elebi,G.: Stable expression andcharacterization of recombinanthuman heteromeric N-methyl-n-aspartate receptor subtypesNMDAR1A/2A andNMDAR1AJ2B in mammaliancells, 367
Vas deferens, melatonin modulation ofnAChRS, in rat, 18
Vascular function, gonadal steroid effectson, 1
Vascular smooth muscle, mitogen-acti-vated protein kinase activationby serotonin in, 1541
Vasculature, pulmonary, antibody-conju-gated plasminogen activator tar-geting to, 1026
Vasoactive intestinal peptide
blood-brain barrier drug delivery, CNSeffects, in rats, 77
and cholecystokinin mechanisms of ac-tion, in canine GI tract, 306
secretin receptor specificity, in rat, 555Vasodilation
ACh- and NO-mediated, inhibition bylipopolysaccharide, 918
coronary, nicorandil effects, in humantissue, 1220
Vasospasm, coronary, acute and chronicdexfenfluramine and, porcine,1077
Veli#{231}elebi, G., see Varney, M. A., 367Veng-Pedersen, P., see Widness, J. A.,
1205Ventricular fibrillation, Re 22-9194 ef-
fects on, in dogs, 877Ventricular function, levosimendan effects
on, 120Ventricular myocytes, cGMP effects on L-
type calcium current and contrac-tions in, in guinea pig, 1274
Ventricular papillary muscle, left,mechano-energetic effects of cm-makalim on, in guinea pig, 464
Vergara, P., Woskowska, Z., Cipris, S.,Fox-Threlkeld, J. E. T. andDaniel, E. E.: Mechanisms of ac-tion of cholecystokinin in the ca-nine gastrointestinal tract: Releof vasoactive intestinal peptideand nitric oxide, 306
Verma, M., see Olnes, M. J., 1566
Vincristine, neurotoxicity, glutamate ef-fects on, 410
VIP, see Vasoactive intestinal peptideViruses
HNinhibition by calanolide A, 645reverse transcriptase inhibition by
calanolide A, 652met-enkephalin and AZT effects
against, in murine cells, 1268Vistica, D. T., Kenney, S., Hursey, M. and
Boyd, M. R.: Rele of membrane
potential in the accumulation ofquaternized ellipticines by hu-man tumor cell lines, 1018
Voltage-sensitive calcium channels, N-type, and spinal antinociceptionin rat neuropathic pain, 1243
Vonvoigtlander, P. F., see Merchant, K.M., 1392
Voskuy, R. A., see Hoogerkamp, A., 803Votta, B., see Badger, A. M., 1453Vouros, P., see Koudriakova, T., 1300Vyas, S. J., Mi, Z. and Jackson, E. K.: The
inhibitory effect of angiotensin IIon stimulus-induced release ofcAMP is augmented in the genet-ically hypertensive rat kidney,114
Wakimasu, M., see Masuda, Y., 675Walsh, A. H., see AIeo, M. D., 1318Walsh, S. L, Suffivan, J. T., Preston, K. L.,
Garner, J. E. and Bigelow, G. B.:Effects of naltrexone on responseto intravenous cocaine, hydro-morphone and their combinationin humans, 524
Wang, J., see Deddish, P. A., 1582; Todaka,K., 120
Wang, L.-X., see Deddish, P. A., 1582Wang, T., see Aleo, M. D., 1318Wang, Y.-X., see Bowersox, S. S., 1243Wanwimolruk, S., see Thao, X.-J., 1327Watanabe, M., see Nomura, Y., 830
Watanabe, T., see Ito, C., 271Watanabe, Y., Ham, Y., Tamagawa, M.
and Nakaya, H.: Inhibitory effectof amiodarone on the muscarinicacetylcholine receptor-operatedpotassium current in guinea pigatrial cells, 617
Waterhouse, B. D., Gould, E. M. and Beka-vac, I.: Monoaminergic substratesunderlying cocaine-induced en-hancement of somatosensory-evoked discharges in rat barrelfield cortical neurons, 582
Watt, A. P., see Bristow, L J., 492Wattle, J., see Janssen, L. J., 813Watts, S. W.: Serotonin activates the mi-
togen-activated protein kinasepathway in vascular smooth mus-cle: Use of the mitogen-activatedprotein kinase kinase inhibitorPD098059, 1541
Weight, F. F., see Brauneis, U., 1063Welch, S. P., see Pugh, G., Jr., 608Wenzel, S., Stolte, H. and Soose, M.: Ef-
fects of siibinin and antioxidantson high glucose-induced alter-ations of fibronectin turnover inhuman mesangial cell cultures,1520
Wheeler, H. R., see Boyle, F. M., 410Widness, J. A., Veng-Pedersen, P.,
Schmidt, R. L, Lowe, L S., Kis-taM, J. A. and Peters, C.: In vivo1mI�Erythropoietin pharmacoki-netics are unchanged after anes-thesia, nephrectomy and hepato-ctomy in sheep, 1205
Wiegand, H., McIntosh, L J., Gotzsch, U.and Kramer, U.: Effects of tetran-drine on spontaneous and evokedrelease of acetylcholine at themouse neuromuscular junction,891
Wilkinson, G. R., see Kim, R. B., 4Willette, R. N., see Barone, F. C., 948Williams, S. A., see Fischman, A. J., 939Wilson, R., see Kolesnikov, Y. A., 502Wilson, S., Chambers, J. K., Park, J. E.,
Ladurner, A., Cronk, D. W.,Chapman, C. G., Kallender, H.,Browne, M. J., Murphy, G. J., andYoung, P. W.: Agonist potency atthe cloned human beta-3 adreno-
ceptor depends on receptor ex-pression level and nature of as-say, 214
Winkler, J. D., Eris, T., Sung, C.-H.,Chabot-Fletcher, M., Mayer, R.J., Surette, M. B. and Chilton, F.H.: Inhibitors of coenzyme A-in-dependent transacylase induceapoptosis in human HL-60 cells,956
Withdrawalacute nicotine, transdermal nicotine
and, 450anticonvulsant, benzodiazepine receptor
ligand characteristics, in mice,561, 573
chronic cocaine, CRF and CRF-RlmRNA levels during, in rat brainand pituitary, 351
Wlodarczyk, B., see Bennett, G. D., 1237Wlos, J., see Sparago, M., 1043Wong, D. L., see Morita, K., 379Woods, J. H., see Butelman, E. R., 934; Yu,
J., 507; Zernig, G., 23Woodward, D. F., Nieves, A. L. and Fried-
laender, M. H.: Characterizationof receptor subtypes involved inprostanoid-induced conjunctivalpruritus and their role in mediat-ing allergic conjunctival itching,137
Woskowska, Z., see Vergara, P., 306Wu, D. and Pardridge, W. M.: Central ner-
vous system pharmacologic effectin conscious rats after intrave-nous injection of a biotinylatedvasoactive intestinal peptide ana-log coupled to a blood-brain bar-rier drug delivery system, 77
Wu, Y.-N. and Johnson, S. W.: Pharmaco-logical characterization of inwardcurrent evoked by N-Methyl-D-aspartate in dopamine neurons inthe rat brain slice, 457
Xie, H., Laher, I. and Bevan, J. A.: Proteinkinase C modulates flow-initiatedcontraction, 668
Xu, J. Y., Seyed-Mozaffari, A., Archer, S.and Bidlack, J. M.: N-Cyclobutyl-methyl analog of normorphinone,14a,l4’13-[dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis[7,8-dihy-dro-N-(cyclobutylmethyl)-nor-morphinone]: A short-term opioidagonist and long-term mu-selec-tive irreversible opioid antago-nism, 539
Xu, Y.-F. and Atchison, W. D.: Effects ofw-agatoxin-NA and w-conothxin-MVIIC on perineurial Ca� andCa4 ‘-activated K� currents ofmouse motor nerve terminals,1229
Yamada, H., see Mukai, M., 822
1996 Index 1609
Yamada, K., see Mukai, M., 822Yamada, T., Niinuma, K., Lemaire, M.,
Terasaki, T. and Sugiyama, Y.:Mechanism ofthe tissue distribu-tion and biliary excretion of thecyclic peptide octreotide, 1357
Yamaguchi, I., see Yamazak.i, M., 1157Yamamoto, Y., see Tachibana, I., 1404Yamawaki, S., see Shimizu, M., 1551Yamazaki, H., see Kim, R. B., 4Yamazaki, M., Matsuoka, N., Maeda, N.,
Ohkubo, Y. and Yamaguchi, I.:N-(4-Acetyl-l-piperazinyl)-p-flu-orobenzamidemonohydrate amo-liorates the impaired memory ofrats in passive avoidance, watermaze and eight-arm radial mazetasks through a novel mechanismofaction, 1157
Yanagthara, N., see Minami, K., 838Yang, C.-H., Shyr, M.-H., Tan, P. P. C. and
Chan, S. H. H.: Participation ofAT1 and AT2 receptors in the dif-ferential interaction between an-giotensin II or III and alpha-2 ad-renoceptors in the nucleusreticularis gigantocellularis incardiovascular regulation and an-tinociception in rats, 795
Yao, J.-A., see Tseng, G.-N., 844Yao, J.-A., see Tseng, G.-N., 865
Yao, J.-A., Trybuiski, E. J. and Tseng, G.-N.: Quinidine preferentiallyblocks the slow, delayed rectifierpotassium channel in the restedstate, 856
Yi, G.-H., see Todaka, K., 120Yokoyama, H., see Thao, X.-J., 1327Yoshioka, T., Ohno, H. and Uematsu, T.:
Pyruvate dehydrogenase com-plex-catalyzed formation of N-arylacetohydroxamic acids fromnitroso aromatic compounds inrat isolated cells and perfused or-gans, 1282
Young, P. W., see Wilson, S., 214Yu, J., Butelman, E. R., Woods, J. H.,
Chait, B. T. and Kreek, M. J.: Invitro biotransformation of dynor-phin A (1-17) is similar in humanand rhesus monkey blood as stud-ied by matrix-assisted laser de-sorption/ionization mass spec-trometry, 507
Yuan, J., see Sparago, M., 1043
Zago, W. M., see Markus, R. P., 18Zeevalk, G. D. and Nicklas, W. J.: Hype-
thermia and metabolic stress:Narrowing the cellular site ofearly neuroprotection, 332
Zensho, H., see Shimizu, M., 1551
Zernig, G., Burke, T., Lewis, J. W. andWoods, J. H.: Mechanism of dc-cinamox blockade of opioid recep-tors: Evidence from in vitro andex vivo binding and behavioral as-says, 23
Zhang, J., see Slotkin, T. A., 478Zhang, L., see Brauneis, U., 1063Zhao, X.-J., Yokoyama, H., Chiba, K.,
Wanwimolruk, S. and Ishizaki,T.: Identification of human cyte-chrome P450 isoforms involved inthe 3-hydroxylation of quinine byhuman liver microsomes and ninerecombinant human cytochromesP450, 1327
Thou, Y., Spangler, R., LaForge, K. S.,Maggos, C. E., Ho, A. and Kreek,M. J.: Corticotropin-releasing fac-tor and type 1 corticotropin-releasing factor receptor messen-ger RNAs in rat brain andpituitary during “binge”-patterncocaine administration andchronic withdrawal, 351
Thu, B., see Tseng, G.-N., 844Thu, H., see Piletz, J. B., 694Ziprasidone, and � receptors, PET
analysis, 939Zumbado, M., see Boada, L. D., 1123
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