THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Copyright C 1972 by The Williams & Wilkins Co.vol. 182, No. 3

Printed in U.S.A.

Volume 182, July-September 1972

533

INDEX

Acara, M. and Rennick B. : Renal tubular trans-

port of aeetylcholine and atropiae : Enhance-meat and inhibition, 14

Acara, M. and Rennick, B. : Renal tubular trans-

port of choline : Modifications caused byintrarenal metabolism, 1

Acetylation method, sensitive assay for hepatie

N-demethylation of chioreyclizine in vitro,

312Acetyleholine

acetyicholine mustard and, comparison of

action on muscarime and iucotinie receptors,

303atropine and, renal tubular transport, enhance-

meat and inhibition, 14-induced smooth muscle contraction, effect of

ouabain, 378Acetyleholine mustard , (chloroethylmethylami-

noethyl acetate) , acetylcholine and, compari-son of action on muscarinic and nicotinic

receptors, 303Action potential, of squid giant axons, blockade

by allethrin, mechanism of negative tem-

perature coefficient, 442Adenosine triphosphatase, effect on uptake of

ouabain by rabbit myometrium, 166Adrenergic drugs

sterie aspects, accumulation of (-)- and

(+)-norepinephrine-”C by peripheral tissuesof rat, 273

steric aspects, influence of various factors onstereoseleetivity of pre- and postjunetioaalsites to norepinephrine isomers in isolatedrat vasa deferentia, 101

Adrenergic neurons, in perfused guinea-pig heart,

mechanism of action of nicotine in, 454Adrenergic receptor

alpha , activity and melanophore stimulatinghormone action �n melanophores , sulfhydryl

requirement, 93beta, blockade in rat, 256

Adriamyeindaunomycin and, identification of new metab-

olites of, 70

daunomycin and, metabolism via reductiveglycosidic cleavage, 63

Agid, Y., see Javoy, F., 454

Akerman, S. B. A., see Ross, S. B., 351Alcohol, marihuana and, comparison of effects on

temporally controlled operant in humans, 195

Allethrin, nerve blocking action, mechanism of

negat ive temperature coefficient, 442Amatuzio, D. S., Bates, H. A. and Hay, L. J.:

Observations on the interactions of protaminewith mouse whole blood components, 528

Aminoguanidine, quinidine and, effect on hista-mine levels in rat and rabbit blood vessels,239

Amphetamine-induced release of norepinephrine

from rat cerebral cortex in vitro, characteris-

tics, 284

d-Amphetamine, as cause of anorexia in rats, 464

Anesthetic effect, local, of three N-w-haloalkyl-N-methylaminoaceto-2,6-xylidide derivatives,

cyelization in relation to, 351Aniline, effect on reserpine metabolism in vitro,

500Anorexia, in rats, induced by SK&F 1-39728,

fenfiuramine and (I-amphetamine, 464Antihypertensive agents (methyldopa , hydrala-

zine and guanethidine), contribution ofcentral nervous system to action of, 135

Anti-inflammatory drugs, steroidal and iionste-

roidal, effects on integrity in vivo of rat liver

lysosomes, 179Antimalarial drug

4,4’-diformamidodiphenylsulfone, pharmacol-

ogy in dog and monkey, 34

4,4’-diformamidodiphenylsulfone, pharmacol-ogy in man, 48

Antimitotic compounds, ability to inhibit rathindpaw edema, 344

Aorta, rat, contractile responses to norepineph-rine and tyramine, 264

Arrhythmias , cardiac , digi talis-induced, sup-pression by clonidine, 218

Asbell, M. A., Schwartzbach, E., Bullock, F. J.

and Yesair, D. W. : Daunomycin andadriamycin metabolism via reductive gly-

eosidie cleavage, 63Asbell, M. A., see Bullock, F. J., 70

Atriaguinea pig, in vitro effects of Rb 7-2956, 399rat, responses to isoproterenol, effects of

propranolol, practolol and butoxamine, 256Atropine

acetylcholine and , renal tubular transport,

enhancement and inhibition, 14effects on cardiovascular function in squirrel

monkey during behavioral experiments, 204

534 INDEX

ylalanine, 155

Brasted, M., see Westfall, T. C., 409

effects 011 ouabain-induced changes in automa-

ticity of blood-perfused canine papillary

muscle, 388

Axelrod, J.see Molinoff, P. B., 116

see Saavedra, J. M. , 363

Azzaro, A. J., see Ziance, It. J. , 284

Bartl, P., see Dalton, C., 491Bates, H. A., see Amatuzio, 1). 8., 528Baum, T. , Shropshire, A. T. and Varner, L. L.:

Contribution of the central nervous system to

the action of several antihypertensive agents

(methyldopa, hydralazine and guanethidine),

135

Bend, J. it, see hook, (. E. IL, 474Bevan, J. A. and Su, C. : Uptake of nicotine by the

sympathetic nerve terminals in the blood

vessel, 419

Benzphetamine N-demethylase , concent rations i a

rabbit lung and liver subeellular fractions,

4741-Benzyl-�1-methoxy-3-trifluoromet hylphenethyla-

mine, see SK&F 1-39728Betaine, intrarenal metabolism of choline to, 1Bile, formation itt sheep, dogs, rats, guinea pigs

and rabbits, effect of ethacrynic acid, 27Biphenyl 4-hydroxylase , concentrat ions in rabbit

lung and liver subcellular fractions, 474

Blehm, I). J., see Johnson, E. M., Jr., 56

Blood, whole, components, mouse, interactionswith protamine, 528

Blood pressurein squirrel monkey during behavioral experi-

meats, effects of propranolol, phentolamineand methyl atropine, 204

spontaneous running activity , salt appetite

and, in ovariectomized rats, effect of oral

contraceptive, 335

Blood vessel(s)

mammalian, disposition of histamine, 239

uptake of nicotine by sympathetic nerve ter-

minals in, 419

Borzelleca, J. F., see Putney, J. W., Jr., 515

Bouvet, D., see Javoy, F., 454

Bradykinin-induced smooth muscle contraction,

effect of ouabain, 378

Braincat, effects of 2,5-dimethoxy-4-methylamphet-

amine on, 145

rat, assay for tryptamine in, 363

rats, monoamine stores, effects of SK&F 1-39728,

fenfluramine and d-amphetainine , 464serotonin turnover, in morphine tolerant-

dependent mice, influence of p-chlorophen-

Bretyliumeffect oti activity of dopamine-�-hydroxylase

and tyrosine hydroxylase in rat hearts and

ganglia, 116effects on nicotine-induced changes in perfused

guinea-pig heart, 409Brimijoin, S., see Molinoff, P. B., 116Bruni, H. J., see Bullock, F. J., 70Buckley, J. P., see Kline, R. L., 399Bullock, F. J., Bruni, H. J. and Asbell, M.

A. : Identification of new metabolites ofdaunomvcin and adriamycin, 70

Bullock, F. J., see Asbell, M. A., 63Butoxamine, effect on responses to isoproterenol

of rat uterus, atria and fundus, 256N-t-Butylnorchlorcyclizine, in vivo and in vitro

N-dealkylation to norchlorcvclizine by rat,

507

Calcium, serum, concentration in rats, effect of

urethane, 522Caple, I., see Shaw, H., 27Cappell, H., Webster, C. D., Herring, B. S. and

Ginsberg, R. : Alcohol and marihuana : Acomparison of effects on a temporally con-

trolled operant in humans, 195Cardiac glycosides, uptake by rabbit and rat

myometrium, 166

Cardiovascular function , in squirrel monkey

during behavioral experiments, effects of

propranolol, phentolamine arid methyl atro-pine, 204

Catecholaminesbinding to human serum albumin, 295

depletion, effect on activity of dopamine.$-hydroxylase and tyrosine hydroxylase in rat

hearts and ganglia, 116glucose release from rabbit liver slices induced

by, antagonism by propranolol and phentol.

amine, 370Cat(s)

neuropharmacological examination of 2,5-

dimethoxy-4-methylamphetamine in, 145suppression by clonidine of digitalis-induced

cardiac arrhythmias, 218sympathetic nervous system, effect of chronic

treatment with pargyline and l-dopa, 130Central nervous system

contribution to action of several antihyper-

tensive agents (methyldopa, hydralazineand guanethidine), 135

neurons, release of norepinephrine from, 284Cerebral cortex, rat, characteristics of in vitro

amphetamine-induced release from , 284

Chan, P. S., see M#{252}hlbachov#{225},E., 370Cheney, D. L., Judson, B. A. and Goldstein, A.:

Failure of an opiate to protect mice against

naloxone-precipitated withdrawal, 189

535

and liver suhcellular fractions, 474

INDEX

Chickenenhancement and inhibition of renal tubular

transport of acetylcholine and atropine, 14

modifications iii renal tubular transport of

choline caused by ilitrarenal metabolism, 1Chlorcyclizine, hepatic N-demethylation in

vitro, sensitive assay for, 312Chloroethylmethylami noethyl ace tate , see Ace-

tyicholine mustard

p-Chlorophenylalanine , influence OIl morphinetolerance and physical dependence and re-gional brain serotonin turnover in morphine

tolerant-dependent mice, 155

Choline , renal tubular transport , modificat ionscaused by intrarenal metabolism, 1

Clonidine (St-155) , suppression of digitalis-in-

duced cardiac arrhythmias, 218

Cocaineeffect on accumulation of norepinephrine isomers

in rat vasa deferentia, 101effects OR nicotine-induced changes in perfused

guinea-pig heart, 409effects on nicotine uptake in rabbit aortic strip,

419isomers, effect on uptake of (-)- and (+)-nor-

epinephrine-”C by rat peripheral tissues, 273pretreatment, influence on effects of norepi-

nephrine and tyramine on rat aorta, 264

Coichicine, derivatives, correlation of antimitoticactivity with inhibition of sodium tirate-

induced rat hindpaw edema, 344

Compound 48/80, effect on histamine levels inrat and rabbit blood vessels, 239

Cooper, C. W. , see Peng, T.-C. , 522Costa, E., see Groppetti, A., 464Cytochrome P-450, concentrations in rabbit lung

Dalton, C., Kamm, J. J. and Bartl, P. : 5,5’-l)i-phenyl-2-thiohydantoin (1)PTH) : An inducer

of microsomal drug-metabolizing enzymes,491

Daniel, E. E., see Murthy, R. V. , 166

Danon, A. and Sapira, J. D. : Binding of cate-cholamines to human serum albumin, 295

I)aunomyci n

adriamycin and, identification of new metab-olites of, 70

adriamycin and, metabolism via reductive

glycosidie cleavage, 63N-Dealkylation, in vivo and in vitro, of N-t-bu-

tylnorchlorcyclizine to norchlorcyclizine by

rat, 507N-Demethylation, hepatic, of chlorcyclizine

in vitro, sensitive assay for, 312

Desipramineeffects on nicotine uptake in rabbit aortic strip,

419

pretreatment, influence on effects of norepi-

aephrine and tyramine on rat aorta, 264l)eslanoside-induced cardiac arrhythmias , sup-

pression by clonidine, 2184, 4’-Diaminodiphenylsulfone, role of 4 , 4’-di-

formamidodiphenyisulfone it dog and monkeyin relation to, 34

Dibenamine, action on melanophores of lizard, 934,4’-Diformamidodiphenylsulfone

antimalarial drug, pharmacology in dog and

monkey, 34, 48antimalarial drug, pharmacology in man, 48

Digitalis-induced cardiac arrhythmias, suppres-

sion by clonidine, 218

Digitoxin, uptake by rabbit and rat myometrium,

166

4-(3,4-Dimethoxybenzyl) -2 -imidazolidinone, see

Ro 7-2956

2,5 - Dimethoxy -4 - methylamphetamine, neuro-pharmacological examination , 145

Dionne, H. A., see Gillis, H. A., 2185,5’-Diphenylhydantoin, as inducer of microsomal

drug-metabolizing enzymes , comparison with5,5’-diphenyl-2-thiohydantoin, 491

5 ,5’-Diphenyl-2-thiohydantoin, inducer of mi-

crosomal drug-met abolizing enzymes , 491

Dogblood-perfused papillary muscle preparation,

automaticity in, effects of therapeutic and

toxic doses of ouabain, 388

effects of norepinephrine and propranoiol onmyocardial subcellular distribution of t ri-glycerides and free fatty acids, 246

man and, mass spectrometric identification ofsix new metabolites of propranolol in, 83

modifications in renal tubular transport of

choline caused by intrarenal metabolism, 1monkey and, pharmacology of antimalarial

drug 4,4’-diformamidodiphenylsulfone in, 34

sheep, rats, guinea pigs, rabbits and, effect of

ethacrynic acid on bile formation in, 27Dopa, effect on activity of dopamine-fi-hydrox-

ylase and tyrosine hydroxylase in rat hearts

and ganglia, 116l-Dopa, pargyline and, chronic treatment, effect

on sympathetic nervous system, 130

Dopamineamphetamine-induced release from rat cerebral

cortex, 284brain, effect of 2,5-dimethoxy-4-methylam-

phetamine on, 145

concentrations in rat brain, effects of SK&F

1-39728, fenfluramine and d-amphetamine, 464synthesis in dopaminergic terminals of rat

striatum, feedback control, 454Dopamine-fl-hydroxylase, tyrosine hydroxylase

and, induction in rat hearts and sympathetic

ganglia, 116

536 INDEX

351

Edema, sodium urate-induced, in rat hindpaw,inhibition by colchiciae derivatives correlated

with antimitotic activity, 344Ellis, S., see M#{252}hlbachov#{225},E., 370Endoh, M., see Hashimoto, K., 388End-plate membranes, mechanisms of dual action

of nicotine, 427

Enovid, effect on spontaneous running activity,

salt appetite and blood pressure of ovariec-

tomized rats, 335Enzymatic assay, specific and sensitive, for

tryptamine in tissues, 363

Enzymesdistribution , comparison between subcellular

fractions of rabbit lung and liver, 474

drug-metabolizing, microsomal , induced by5 ,5’-diphenyl-2-thiohydantoin, 491

extrusion from lysosomes, effects of anti-in-flammatory drugs, 179

Epinephrinebinding to human serum albumin, 295-induced glucose release from rabbit liver slices,

antagonism by propranolol and phentolamine,

370Erythrityl tetranitrate, degradation by rat liver,

56Ethacrynic acid, effect on bile formation in sheep,

dogs, rats, guinea pigs and rabbits, 27Ethylmorphine N-demethylase, activity in rat

liver, effect of 5 , 5’-diphenyl-2-thiohydantoin,

491Ethynodiol diacetate , norethindrone , progester-

one and, whole body distribution in pregnant

mouse, 328

Fenfluramine, as cause of anorexia in rats, 464Fouts, J. R., see Hook, G. E. B., 474Free fatty acids, triglycerides and, myocardial

subcellular distribution, effects of norepi-nephrine and propranolol , 246

Fregly, M. J. : Effect of an oral contraceptive onspontaneous running activity, salt appetiteand blood pressure of ovariectomized rats, 335

Freudenthal, B. I., Martin, J. and Wall, M. E.:The whole body distribution of norethindrone,

ethynodiol diacetate and progesterone in thepregnant mouse, 328

Friedman, E., see Wallach, M. B., 145

Frog

rectus abdominus preparations, comparison ofact ions of acetylcholine and acetylcholine

mustard on, 303

sartorius muscle end-plate membranes, mecha-nisms of dual action of nicotine, 427

sciatic nerve, cyclization of three N-w-haloalkyl-N-methylaminoaceto-2,6-xylidide derivativesin relation to their local anesthetic effect in,

Fundus, rat, responses to isoproterenol, effects

of propranolol, practolol and butoxamine, 256

Gaffney, T. E., see Walle, T., 83Gershon, S., see Wallach, M. B., 145Gillis, R. A., Dionne, 11. A. and Standaert, F. G.:

Suppression by clonidine (St-155) of cardiac

arrhythmias induced by digitalis, 218Ginsberg, H., see Cappell, H., 195

Glaviallo, V. V., see Masters, T. N., 246

Glowinski, J., see Javoy, F., 454Glucose, release from rabbit liver slices induced

by catecholamines, antagonism by pro-pranolol and phentolamine, 370

Glyceryl trinitrate, degradation by rat liver, 56

Glycosides, cardiac, uptake by rabbit and rat

myometrium, 166Goldman, J. M. and Hadley, M. E. : Sulfhydryl

requirement for alpha adrenergic receptoractivity and melanophore stimulating hor-

mone (MSH) action on melanophores, 93Goldstein, A., see Cheney, D. L., 189

Gram, T. E., see Hook, G. E. II., 474

Griffin, J. D., Szaro, 11. P. and Weltmaii, J. K.:Ouabain antagonism of smooth muscle con-

traction, 378Grollman, A., see Krishnamurty, V. S. II., 264

Groppetti, A., Misher, A., Naimzada, M.,Revuelta, A. and Costa, E. : Evidence that inrats 1-benzyl-$-methoxy-3-trifluoromethyl-

phenethylamine (SK&F 1-39728) dissociatesanorexia from central stimulation and actions

on brain monoamine stores, 464Guanethidine

effects on mcotine uptake in rabbit aortic strip,

419methyldopa , hydralazine and , antihypertensive

agents, contribution of central nervous system

to action of, 135

pretreatment, effect on accumulation of (-)-

and (+)-norepinephrine-”C by rat peripheral

tissues, 273

Guinea pig(s)

atria, in vitro effects of Ho 7-2956, 399

heart, isolated, quantitative comparison of

effects of exogenous and immunologicallyreleased histamine on, 227

intestinal smooth muscle, contraction, antago-

aism by ouabain, 378

perfused heart, adrenergic neurons, mechanism

of action of nicotine in, 409

sciatic nerve, cyclization of three N-w-haloalkyl..

N-methylaminoaceto-2,6-xylidide derivatives

in relation to their local anesthetic effects in,

351

sheep, dogs, rats, rabbits and, effect of

ethacrynic acid on bile formation in, 27

537INDEX

Hadley, M. E., see Goldman, J. M., 93

N-w-Haloalkyl-N-methylaminoaceto-2,6-xylidide,

derivatives, cyclization in relation to their

local anesthetic effect, 351

Harkey, A. B., see Johnson, E. M., Jr., 56Hashimoto, K., Kimura, T. and Endoh, M.:

Effects of therapeutic and toxic doses ofouabain on automaticity in the blood-perfused

canine papillary muscle preparation, 388Hay, L. J., see Amatuzio, D. S., 528

Heart(s)digitalis-induced arrhythmias, suppression by

clonidine, 218

isolated, quantitative comparison of effects of

exogenous and immunologically released

histamine on, 227perfused, guinea-pig, adrenergic neurons, mech-

anism of action of nicotine in, 409rat, sympathetic ganglia and, induction of

dopamiae-fl-hydroxylase and tyrosine hy-droxylase in, 116

Heart rate, in squirrel monkey during behavioral

experiments, effects of propranolol, phentol-

amine and methyl atropine, 204Heath, T., see Shaw, H., 27

Herd, J. A., see Kelleher, II. T., 204

Herring, B. S., see Cappell, H., 195

Hexamet honium

effects on nicotine-induced changes in perfused

guinea-pig heart, 409effects on nicotine uptake in rabbit aortic strip,

419

Hexobarbital, effect on reserpine metabolism in

vitro, 500

H indpaw , edema , rat , sodium urate-induced,inhibit 1011 by colchicine derivatives correlatedwith ant imitotic activity , 344

Histamine

disposition in mammalian blood vessels, 239

exogenous and immunologically released, quaIl-

titative comparison of effects on isolatedheart, 227

-induced smooth muscle contraction, effect ofouabain, 378

Ho, I. K., Lu, S. E., Stolman, S., Loh, H. ii., and Way,E. L. : Influence of p-chlorophenylalanine on

morphine tolerance and physical dependenceand regional brain serotonin turnover studies

in morphine tolerant-dependent mice, 155

Hoel, D., see Hook, Cl. E. H., 474

Hook, G. E. H., Bend, J. H., Hoel, D., Fouts, J.

H. and Gram, T. E. : Preparation of lung

microsomes and a comparison of the distri-bution of enzymes between subcellular frac-

tions of rabbit lung and liver, 474lowland, H. D. and Spector, S. : Disposition of

histamine iii mammalian blood vessels, 239

Hudgins, P. M. and Stubbins, J. F. : A comparison

of the action of acetylcholine and acetyl-choline mustard (chloroethylmethylamino-

ethyl acetate) on muscarinic and nicotinicreceptors, 303

Hydralazine , met hyldopa , guanethidine and,

aatihypertensive agents , contribution ofcentral nervous system to action of, 135

Hydrocortisone, capacity to alter in vivo integrity

of rat liver lysosomes, 1796-Hydroxydopamine

effect on accumulation of norepinephrine

isomers in rat vasa deferentia, 101pretreatment , effects on nicotine-induced

changes in perfused guinea-pig heart, 409

pretreatment, influence on effects of norepi-

nephrine and tyramine on rat aorta, 264

Hypocalcemia, caused by urethane in rats, 522Hypotension, after prolonged treatment with

pargyline or l-dopa, cause, 130

Ignarro, ii. J. : Lysosome membrane stabilizationin vivo : Effects of steroidal and nonsteroidalanti-inflammatory drugs on the integrity of

rat liver lysosomes, 179Infrared spectroscopy, use in identification of

metabolites of daunomycin and adriamycin,

70

Iproniazid, pretreatment, effect on accumulation

of (-)- and (+)-norepiaephrine-”C by rat

peripheral tissues, 273Isomers

of norepinephrine, accumulation by rat periph-eral tissues, 273

of norepiriephrine in isolated rat vasa deferentia,influence of various factors on stereoselec-

tivity of pre- and postjunctional sites to, 101Isoprotereriol

-induced glucose release from rabbit liver slices,antagonism by propranolol and phentol-

amine, 370responses of rat uterus, atria and fundus to,

antagonism by propranolol , practolol andbutoxamine, 256

Isosorbide dinitrate, degradation by rat liver, 56

Jacobson, M. M., Tsai, I., Poland, A. and

Kuntzman, H. : A sensitive assay for thehepatic N-demethylation of chlorcyclizine in

vitro, 312

Javoy, F., Agid, Y., Bouvet, D. and (ilowiaski, J.:

Feedback control of dopamine synthesis in

dopaminergic terminals of the rat striatum,

454

Johnson, E. M., Jr., Harkey, A. B., Blehm, D. J.

and Needleman, P. : Clearance and metabo-

lism of organic nitrates, 56

Judson, B. A., see Cheney, D. L., 189

538 INDEX

Kamm, J. J., Szuna, A. and Kuntzman, H. : Studies

on an unusual N-dealkylation reaction. I.

In vivo and in vitro N-dealkylation of N-I-

butylchlorcyclizine to norchiorcyclizine bythe rat, 507

Kamm, J. J., see Dalton, C., 491

Kelleher, II. T., Morse, W. H. and Herd, J. A.:Effects of propranolol, phentolamine and

methyl atropine on cardiovascular function

in the squirrel monkey during behavioral

experiments, 204

Kidneytubular transport of acetylcholine and atropine,

enhancement and inhibition, 14

tubular transport of choline, modificationscaused by intrarenal metabolism, 1

Kidwai, A. M., see Murthy, H. V., 166

Kimura, T., see Hashimoto, K., 388Kirpekar, S. M., see Puig, M., 130Kline, R. L. and Buckley, J. P. : In vitro myocar-

dial effects of 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956), 399

Krell, H. D. and Patil, P. N. : Steric aspects of

adrenergic drugs. XIX. Influence of various

factors on the stereoselectivity of pre- and

postjunctional sites to norepinephrine isomersin isolated rat vasa deferentia, 101

Krell, R. D. and Patil, P. N. : Steric aspects of

adrenergic drugs. XX. Accumulation of (-)-

and (+)-norepinephrine-”C by peripheral

tissues of the rat, 273Krishnamurty, V. S. R. and Groliman, A. : Con-

tractile response of rat aorta to norepine-phrine and tyramine, 264

Kuntzman, H.,

see Jacobson, M. M., 312

see Kamm, J. J., 507

Levi, R. : Effects of exogenous and immunolog-ically released histamine on the isolated

heart: A quantitative comparison, 227

Levorphanol, failure to protect mice againstnaloxone-precipitated withdrawal, 189

Levy, B., see Wasserman, M. A., 256Lidocaine, effects on nicotine-induced changes

in perfused guinea-pig heart, 409Liver

lung and, rabbit, subcellular fractions, corn-

parison of distribution of enzymes between,

474

rat, drug metabolism, in vitro inhibition bymetabolites of progesterone, 320

rat, in vivo and in vitro N-dealkylation of N-t-

butylnorchlorcyclizine to norchiorcyclizinein, 507

rat, lysosomes, integrity in vivo, effects of steroi-

dal and nonsteroidal anti-inflammatorydrugs on, 179

rat , microsomal drug-metabolizing enzymes,5 ,5’-diphenyl-2-thiohydantoin as inducer of,

491rat, microsomal N-dernethylation of chlor-

cyclizine in vitro, sensitive assay for, 312

rat, pathway for daunornycin and adriamycinmetabolism in, 63

rat , rate of degradation of organic nitrates by,

56

slices, rabbit, glucose release by catecholamines,

antagonism by propranolol and phentolarnine,

370Lizard , melanophores , sulfhydryl requirement

for alpha adrenergic receptor activity and

melanophore stimulating hormone action on,

93Loh, H. H., see Ho, I. K., 155Long, II. J., see Soyka, L. F., 320

Lu, S. E., see Ho, I. K., 155

Lungliver and, rabbit, subcellular fractions, corn-

parison of distribution of enzymes between,

474microsomes, preparation, 474

Lysosornes, rat liver, effects of steroidal and

nonsteriodal ant i-inflammatory drugs on

integrity in vivo of, 179

Maling, H. M., see Zweig, M. H., 344

Mancomparison of effects of alcohol and marihuana

On temporally controlled operant in, 195dog and, mass spectrometric identification of

six new metabolites of propranolol in, 83

pharmacology of antimalarial drug 4,4’-di-formamidodiphenylsulfone in, 48

serum albumin, binding of catecholamines to,295

Mannitol hexanitrate, degradation by rat liver, 56Maren, T. H., see Sonntag, A. C., 34, 48Marihuana, alcohol and, comparison of effects on

temporally controlled operant in humans, 195Martin, J., see Freudenthal, R. I., 328Mass spectroscopy

high resolution, use in identification of metab-olites of daunomycin and adriamycin, 70

use in identification of six new metabolites ofpropranolol in man and dog, 83

Masters, T. N. and Glaviano, V. V. : The effects of

norepinephrine and propranolol on myocar-

dial subcellular distribution of triglycerides

and free fatty acids, 246Melanophore stimulating hormone and alpha

adrenergic receptor activity action on mela-

nophores, sulfhydryl requirement, 93

Meperidine, effect on reserpine metabolism invitro, 500

Mercurials, action on melanophores of lizard, 93

of

INDEX 539

Metabolism

clearance and, of organic nitrates, 56

drug, in vitro inhibition by metabolites of pro-gesterone, 320

intrarenal, modifications in renal tubular trans-port caused by, 1

microsomal, of 3H-reserpine, 500

of daunomycin and adriamycin via reductive

glycosidic cleavage, 63

of 4 , 4’ -diformamidodiphenylsulfone in man,

48of propranolol in man and dog studied by mass

spectrometry, 83Metabolites

new, of daunornycin and adriamycin, identifi-

cation, 70new, of propranolol in man and dog, mass spec-

trometric identification, 83Metanephrine, effects on nicotine-induced changes

in perfused guinea-pig heart, 409Methyl atropine, propranolol, phentolamine and,

effects on cardiovascular function in squirrel

monkey during behavioral experiments, 204

Methyldopa, hydralazine, guanethidine and,

antihypertensive agents , contribution of

central nervous system to action of, 135

Miceextracellular toxic reactions of some sulfur and

nitrogen mustards, 77

rnicrosomal metabolism of 3H-reserpine, 500morphine tolerant-dependent, influence of

p-chlorophenylalanine on morphine toleranceand physical dependence and regional brain

serotonin turnover studies in, 155pregnant, whole body distribution of nor-

ethindrone, ethynodiol diacetate and pro-

gesterone in, 328

protection against naloxone-precipitated with-

drawal, failure of opiate, 189

whole blood components, interactions with

protamine, 528

Microsomes

drug-metabolizing enzymes, 5,5’-diphenyl-2-

thiohydantoin as inducer of, 491

lung, preparation and comparison of distri-

bution of enzymes between subcellular frac-

tions of rabbit lung and liver, 474

mice, metabolism of 3H-reserpine, 500

Misher, A., see Groppetti, A., 464

Molinoff, P. B., Brimijoin, S., and Axelrod, J.:

Induction of dopamine-�9-hydroxylase and

tyrosine hydroxylase in rat hearts and sym-

pathetic ganglia, 116

Monkey

dog and, pharmacology of antimalarial drug

4, 4’-diformamidodiphenylsulfone in, 34

squirrel, cardiovascular function during be-

havioral experiments, effects of propranolol,

phentolamine and methyl atropine, 204

Monoamine, stores in rat brain, effects of SK&F1-39728, fenfluramine and d-amphetamine,

464

Monoamine oxidase

inhibition, effect on accumulation of norepi-nephrine isomers in rat vasa deferentia, 101

inhibition, effects on dopamine levels in rat

striatum, 454

inhibitors, effect on activity of dopamine-�-

hydroxylase and tyrosine hydroxylase in rathearts and ganglia, 116

Morphine

effects on nicotine-induced changes in perfused

guinea-pig heart, 409

tolerance and physical dependence and regionalbrain serotonin turnover in tolerant-de-

pendent mice, influence of p-chlorophenylal-

anine, 155Morse, W. H., see Kelleher, R. T., 204

M#{252}hlbachov#{225}, E., Chan, P. S. and Ellis, S. : Quan-

titative studies of glucose release from rabbit

liver slices induced by catecholamines andtheir antagonism by propranolol and phen-

tolamine, 370

Munson, P. L., see Peng, T.-C., 522

Murthy, R. V., Kidwai, A. M. and Daniel, E. E.:

The uptake of cardiac glycosides by rabbit

and rat myometrium, 166

Muscarinic receptors, nicotinic and, comparison

of action of acetylcholine and acetylcholine

mustard on, 303

Muscle

papillary , blood-perfused, canine , automa-

ticity in, effects of therapeutic and toxic

doses of ouabain, 388

sartorius, frog, end-plate membranes, mecha-

nisms of dual action of nicotine, 427

smooth, contraction, ouabain antagonism of,

378

Mustards, sulfur and nitrogen, extracellular

toxic reactions, 77

Myocardium, subcellular distribution of triglyc-

erides and free fatty acids, effects of norepi-

nephrine and propranolol, 246Myometrium, rabbit and rat, uptake of cardiac

glycosides by, 166

Naimzada, M., see Groppetti, A., 464

Naloxone-precipitated withdrawal, failure

opiate to protect mice against, 189

Narahashi, T., see Wang, C. M., 427, 442

Needleman, P., see Johnson, E. M., Jr., 56

Nerveblocking action of allethrin, mechanism of

negative temperature coefficient, 442

�540 INDEX

terminals, sympathetic, in blood vessel, uptakeof nicotine, 419

Nervous system

. central , contribution to action of antihyper-tensive agents (methyldopa, hydralazine and

guanethidine), 135central, neurons, release of norpinephrine from,

284sympathetic, effect of chronic treatment with

pargyline and l-dopa on, 130Neurons

adrenergic, in perfused guinea-pig heart, media-

nism of action of nicotine in, 409central nervous system, release of norepi-

nephrine from, 284Nicotine

mechanism of action in adrenergic neurons �I1

perfused guinea-pig heart , 409mechanisms of dual actions On end-plate mem-

branes, 427uptake by sympathetic nerve terminals in

blood vessel, 419Nicotinic receptors, muscarinic and, comparison

of action of acetyicholine and acetylcholine

mustard on, 303

Nitrates, organic, clearance and metabolism, 56p-Nitroanisole, effect on hepatic drug metabolism,

320

Nitrogen and sulfur mustards, extracellular toxic

reactions, 77Norchiorcyclizine, N-dealkylation by rat of N-t-

butylnorchlorcyclizine to, 507Norepinephrine

amphetamine-induced release from rat cerebral

cortex in vitro, characteristics, 284. binding to human serum albumin, 295

brain, effect of 2,5-dimethoxy-4-methylam-phetamine on, 145

concentrations in rat brain, effects of SK&F1-39728, fenfluramine and d-amphetamine,464

content of cat spleen and coeliac ganglia, effectof chronic treatment with pargyline andl-dopa, 130

-induced glucose release from rabbit liver slices,antagonism by propranolol and phentolamine,

370

isomers, in isolated rat vasa deferentia, in-fluence of various factors on stereoselectivity

of pre- and postjunctioaal sites to, 101neuronal uptake , relationship with nicotine-

. induced release of norepinephrine, 409propranolol and, effects on myocardial sub-

cellular distribution of triglycerides and freefatty acids, 246

tyramine and, contractile response of rat aorta. to,264

Norepinephriae-’�C, (-)- and (+)-, accumulation

by peripheral tissues of rat, 273Norethindrone , ethynodiol diacetate , progester-

one and, whole body distribution in pregnant

mouse, 328

Oral contraceptive, effect on spontaneous running

activity, salt appetite and blood pressure of

ovariectomized rats, 335Organic nitrates, clearance and metabolism, 56Ouabain

antagonism of smooth muscle contraction, 378therapeutic and toxic doses, effects on automa-

ticity ill blood-perfused canine papillary

muscle preparation, 388uptake by rabbit and rat myometrium, 166

Papillary muscle, blood-perfused, canine, auto-

maticity in, effects of therapeutic and toxic

doses of ouabain, 388Pargyline

-induced changes in dopainine levels iii rat

striatum, 454l-dopa and, chronic treatment, effect on sym-

pathetic nervous system, 130Paroxon, effect on acetylcholine transport efli-

ciency in kidney, 14Patil, P. N., see Krell, it. 1)., 101, 273

Peng, T.-C., Cooper, C. W. and Munson, P. L.:The hypocalcemic effect of urethane in rats,

522Pentaerythritol trinitrate, degradation by rat

liver, 56Pentolinium, effects on nicotine uptake in rabbit

aortic strip, 419Phenobarbital, as inducer of drug-metabolizing

enzymes , comparison with 5 , 5’-diphenyl-2-thiohydantoin, 491

Phenoxybeazamineaction on melanophores of lizard, 93

effects on nicotine-induced changes in perfused

guinea-pig heart, 409

effects on nicotine uptake in rabbit aortic strip,419

Phentolamineblockade of effects of norel)inephrine and tyra-

mine on rat aorta, 264

propranolol and, antagonism of glucose release

from rabbit liver slices induced by catechol-

amines, 370

propranolol, methyl atropine and, effects on

cardiovascular function in squirrel monkey

during behavioral experiments, 204

Physical dependence, on morphine in mice, tol-

erance and, influence of p-chlorophenylal-

anine on, 155

INDEX 541

Physostigmine , effect on acetylcholine transport

efficiency in kidney, 14Piperocaine , effects on nicotine-induced changes

in perfused guinea-pig heart, 409

Poland, A., see Jacobson, M. M., 312Practolol, effect on responses to isoproterenol of

rat uterus, atria and fundus, 256

Pregnanedione, effect on hepatic drug metabolism,320

Pregnanolone, effect on hepatic drug metabolism,320

Progesterone

metabolites, in vitro inhibition of drug metabo-lism by, 320

norethindrone, ethynodiol diacetate and, wholebody distribution in pregnant mouse, 328

Propranololeffect on responses to isoproterenol of rat

uterus, atria and fundus, 256

effect on Ro 7-2956-induced changes in guinea-pig atria, 399

effects on ouabain-iaduced changes in auto-

maticity of blood-perfused canine papillarymuscle, 388

metabolism in man and dog, mass spectrometricidentification of six new metabolites, 83

norepinephrine and, effects on myocardialsubcellular distribution of triglycerides and

free fatty acids, 246phentolamine and, antagonism of glucose re-

lease from rabbit liver slices induced by

catecholamines, 370

phentolamine, methyl atropine and, effects oncardiovascular function in squirrel monkey

during behavioral experiments, 204Protamine, interactions with mouse whole blood

components, 528Puig, M., Wakade, A. R. and Kirpekar, S. M.:

Effect on the sympathetic nervous system ofchronic treatment with pargyline and l-dopa,

130Putney, J. W., Jr. and Borzelleca, J. F. : Mecha-

nisms of “C-salicylic acid excretion by the

rat submaxillary gland, 515

Quinidine, aminoguanidine and, effect on hista-Inine levels in rat and rabbit blood vessels,

239

Rabbit(s)aortic strips, comparison of actions of acetyl-

choline and acetylcholine mustard on, 303aortic strips, uptake of nicotine, 419blood vessels, disposition of histamine in, 239liver slices, glucose release by catecholamines,

antagonism by propranolol and phentola-mine, 370

lung and liver, subcellular fractions, comparison

of distribution of enzymes between, 474myometrium, rat and, uptake of cardiac gly-

cosides by, 166

sheep, dogs, rats, guinea pigs and, effect ofethacrynic acid on bile formation in, 27

Rat(s)

aorta, contractile responses to norepinephrineand tyramine, 264

blood vessels, disposition of histamine in, 239cerebral cortex, characteristics of in vitro am-

phetamine-induced release from, 284clearance and metabolism of organic nitrates

in, 56contribution of central nervous system to action

of antihypertensive agents (methyldopa,hydralazine and guanethidine) in, 135

daunomycin and adriamycin metabolism eia

reductive glycosidic cleavage in, 63

5 ,5’-diphenyl-2-thiohydantoin as inducer ofmicrosomal drug-metabolizing enzymes in,

491evidence that 1-benzyl-�3-methoxy-3-triflu-

oromethylphenethylamine (SK&F 1-39728)

dissociates anorexia from central stimulationand actions on brain monoamine stores, 464

hearts, sympathetic ganglia and, induction ofdopamine-�9-hydroxylase and tyrosine hy-

droxylase in, 116

hindpaw edema, sodium urate-induced, in-hibition by colchicine derivatives correlated

with antimitotic activity, 344in vitro inhibition of drug metabolism by metab-

olites of progesterone in, 320

in vivo and in vitro N-dealkylation of N-t-butyl-norchlorcyclizine to norchlorcyclizine by,

507hypocalcemic effect of urethane in, 522

jejunum, comparison of action of acetylcholine

and acetylcholine mustard on, 303

liver lysosomes, integrity in vivo, effects of

steroidal and nonsteroidal ant i-inflammatory

drugs on, 179

myometrium, rabbit and, uptake of cardiac

glycosides by, 166ovariectomized, effect of oral contraceptive on

spontaneous running activity, salt appetite

and blood pressure of, 335

peripheral tissues, accumulation of (-)- and

(+)-norepinephrine-’�C by, 273selective beta adrenergic receptor blockade in,

256

sensitive assay for hepatic N-demethylation ofchlorcyclizine in vitro in, 312

sheep, dogs, guinea pigs, rabbits and, effect of

ethacrynic acid on bile formation in, 27

542 INDEX

striatum, dopaminergic terminals, feedbackcontrol of dopamine synthesis in, 454

submaxillary gland, mechanisms of ‘4C-salicylic

acid excretion by, 515tissues, assay for tryptamine in, 363

vasa deferentia, isolated, influence of variousfactors on stereoselectivity of pre- andpostjunctional sites to norepinephrine in,

101

Renal tubule

transport of acetylcholine and atropine, en-hancement and inhibition, 14

transport of choline, modifications caused byintrarenal metabolism, 1

Rennick, B., see Acara, M., 1, 14

Reserpine

effect on accumulation of norepinephrine iso-

mers in rat vasa deferentia, 101

effect OII activity of dopamine-�-hydroxylase

and tyrosine hydroxylase in rat hearts andganglia, 116

effect On histamine levels in rat and rabbit

blood vessels, 239pretreatment, influence on effects of norepi-

nephrine and tyramine on rat aorta, 2643H-Reserpine, microsomal metabolism, 500

Revuelta, A., see Groppetti, A., 464

Ro 7-2956 [4-(3,4-dimethoxybenzyl)-2-imidaz-

olidionel, in vitro myocardial effects, 399Ross, S. B. and Akerman, S. B. A. : Cyclization of

three N -w - haloalkyl -N-methylaminoaceto-

2,6-xylidide derivatives in relation to their

local anesthetic effect in vitro and in vivo, 351

Rutledge, C. 0., see Ziance, H. J., 284

Saavedra, J. M. and Axelrod, J. : A specific andsensitive enzymatic assay for tryptamine intissues, 363

‘4C-Salicylic acid, mechanisms of excretion by ratsubmaxillary gland, 515

Salt appetite , spontaneous running activity,blood pressure and, in ovariectomized rats,

effect of oral contraceptive, 335

Sapira, J. D., see Dalton, A., 295Sartorius muscle, end-plate membranes, frog,

mechanisms of dual action of nicotine, 427Schwartzbach, E., see Asbell, M. A., 63Sciatic nerves, guinea pig and frog, cyclization of

three N - w - haloalkyl - N - methylaminoaceto -

2,6-xylidine derivatives in relation to their

local anesthetic effect in, 351

Scuka, M., see Wang, C. M., 442

Seligman, A. M., see Williamson, C. E., 77

Serotoninbrain, effect of 2,5-dimethoxy-4-methylam-

phetamine on, 145brain, turnover, in morphine tolerant-dependent

mice, influence of p-chlorophenylalanine, 155

concentrations in rot brain, effects of SK&F

1 -39728, fenfluramine and d-amphetami tie,464

-induced smooth muscle contraction, effect of

ouabain, 378Serum albumin, human, binding of catechola-

mines to, 295Shaw, H., Caple, I. and Heath, T. : Effect of

ethacrynic acid on bile formation in sheep,dogs, rats, guinea pigs and rabbits, 27

Sheep, dogs, rats, guinea pigs, rabbits and, effect

of ethacrynic acid on bile formation in, 27Shropshire, A. T., see Baum, T., 135SK&F 1-39728 (1-benzyl-fl-methoxy-3-trifluo-

romethylphenethylamine) , dissociation of

anorexia from central stimulation and actions

OIl brain monoamines stores in rat by , 464

SKF 525A, effect on reserpine metabolism in vitro,

500

Smooth muscle, contraction, ouabaia antagonismof, 378

Sodium thiosulfate, use to prevent toxic effects of

sulfur and nitrogen mustards, 77Sodium orate-induced rat hindpaw edema, in-

hibition by colchicine derivatives correlatedwith antimitotic activity, 344

Sonatag, A. C., Stenger, V. (. and Maren, T. II.:The pharmacology of the antimalarial drug

4, 4’-diformamidodiphenylsulfone in man, 48Sonntag, A. C. , Stenger, V. U. , Vogh, B. P. and

Marezi, T. H. : The pharmacology of the an-

timalarial drug 4 , 4’-diformamidodiphenyl-sulfone (DFD) in dog and monkey, 34

Soyka, L. F. and Long, R. J. : In vitro inhibitionOf drug metabolism by metabolites of pro-

gesterone, 320

Spector, S., see Howland, H. D. , 239Squid, giant axons, mechanism of negative tem-

perature coefficient of nerve blocking action

of allethrin in, 442St-155, see ClonidineStaadaert, F. (l., see Gillis, H. A., 218

Stawarz, 11. J., see Stitzel, H. E., 500

Stenger, V. G., see Sonntag, A. C. , 34, 48

Stitzel, H. E., Wagner, L. A. and Stawars, II. J.:

Studies on the microsomal metabolism of

‘H-reserpine, 500

Stolman, S., see Ho, I. K., 155Striatum, rat, dopaminergic terminals, feedback

control of dopamine synthesis in, 454Stubbins, J. F., see Hudgins, P. M., 303Su, C., see Bevan, J. A., 419

Subcellular fractions, of rabbit lung and liver,

comparison of distribution of enzymes, 474

Submaxillary gland, rat, mechanisms of 14csalicylic acid excretion by, 515

Sulfhydryl requirement, for alpha adrenergicreceptor activity and melanophore stimu-

INDEX 543

lating hormone action on melanophores, 93Sulfur and nitrogen mustards, extracellular toxic

reactions, 77

Sympathetic ganglia, hearts and, rat, induction of

dopamine-$-hydroxylase and tyrosine hy-droxylase in, 116

Sympathetic nerve, terminals, in blood vessel,

uptake of nicotine, 419

Sympathetic nervous system, effect of chronic

treatment with pargyline and l-dopa on, 130Szaro, H. P., see Griffin, J. D., 378Szuna, A., see Kamm, J. J., 507

Temperature coefficient , itegat ive , of nerveblocking action of allethrin, mechanism, 442

Tetrodotoxin , effects on nicotine-induced changes

in perfused guinea-pig heart, 409Tissues

peripheral, rat, accumulation of (-)- and (+)-

norepinephrine-14C by, 273specific and sensitive assay for tryptamine in,

363

Toxic reactions, extracellular, of some sulfur and

nitrogen mustards, 77Triglycerides, free fatty acids and, myocardial

subcellular distribution, effects of norepi-

nephrine and propranolol, 246Tropolone , pretreatment , effect on accumulation

of (-)- and (+)-norepinephrine-’4C by rat

peripheral tissues, 273Tryptamine, in tissues, specific and sensitive

assay for, 363Tsai, I., see Jacobson, M. M., 312

d-Tubocurarineeffects on nicotine-induced changes in end-

plate membranes, 427

effects on nicotine uptake in rabbit aortic strip,

419Tyramine, norepinephrine and, contractile re-

spouse of rat aorta to, 264Tyrosine hydroxylase, dopamine-�9-hydroxylase

and, induction ill rat hearts and sympathetic

ganglia, 116

Urethane, hypocalcemic effect in rats, 522Uterus, rat, responses to isoproterenol, effects of

propranolol, practolol and butoxamine, 256

Varner, L. L., see Baum, T., 135Vas deferens, rat, isolated, influence of various

factors on stereoselectivity of pre- and

postjunctional sites to norepinephrine in, 101

Vogh, B. P., see Sonatag, A. C., 34

Wagner, L. A., see Stitzel, B. E., 500

Wakade, A. IL, see Puig, M., 130

Wall, M. E., see Freudenthal, H. I., 328

Wallach, M. B., Friedman, E. and Gershon,S. : 2,5 - Dimethoxy-4 -methylamphetamine

(DOM) , a neuropharmacological examination,

145Walle, T. and Gaffney, T. E. : Propranolol metab-

olism in man and dog: Mass spectrometricidentification of six new metabolites, 83

Wang, C. M. and Narahashi, T. : Mechanisms of

dual action of nicotine on end-plate mem-

branes, 427

Wang, C. M., Narahashi, T. and Scuka, M. : Mech-

anism of negative temperature coefficient

of nerve blocking action of allethrin, 442

Wasserman, M. A. and Levy, B. : Selective beta

adrenergic receptor blockade in rat , 256Way, E. L., see Ho, I. K., 155

Webster, C. D., see Cappell, H., 195

Webster, M. E., see Zweig, M. H., 344Weltman, J. K., see Griffin, J. D., 378

Westfall, T. C. and Brasted, M. : The mechanismof action of nicotine in adrenergic neurons in

the perfused guinea-pig heart , 409Williamson, C. E., Seligman, A. M. and Witten,

B. : Extracellular toxic reactions of somesulfur and nitrogen mustards, 77

Witten, B., see Williamson, C. E., 77

Yesair, D. W., see Asbell, M. A., 63

Ziance, H. J., Azzaro, A. J. and Rutledge, C. 0.:

Characteristics of amphetamine-induced re-

lease of norepinephrine from rat cerebralcortex in vitro, 284

Zweig, M. H., Maling, H. M. and Webster, M. E.:Inhibition of sodium urate-induced rat

hindpaw edema by colchicine derivatives:Correlation with antimitotic activity, 344