INDEX [jpet.aspetjournals.org]jpet.aspetjournals.org/content/jpet/234/3/local/back...effect, 708...
Transcript of INDEX [jpet.aspetjournals.org]jpet.aspetjournals.org/content/jpet/234/3/local/back...effect, 708...
837
INDEX
Volume 234, July-September 1985
A23187aorta contraction and (rats), 443leukotriene release and, lung parenchyma,
217
Abel, P. W., see Nasseri, A., 350Abernethy, D. R., Greenblatt, D. J., Ameer,
B. and Shader, R. I.: Probenecid im-pairment of acetaminophen and br-azepam clearance: Direct inhibitionof ether glucuronide formation, 345
Abraham, R. T., Benson, L. M. and Jardine,I.: Influence of hepatic oxidative me-tabolism on the immunosuppressiveactivities of 6-thiopurines, 670
Abuse liability
nicotine, intravenous and inhaled, 1triazolam us. pentobarbital, 120
Acetaminophenclearance, probenecid impairment of, 345
hepatic necrosis induced by, cimetidine
and N-acetylcysteine treatment(rats), 550
Acetazolamide, electrolyte reabsorption, in-
hibitory effect, kidney tubules (dogs),
747
N-Acetylation, polymorphism, genetics,liver (hamster), 358
Acetylcholineend-plate receptor-channel complex, ed-
rophonium, physostigmine and
methanesulfonyl fluoride interac-
tions with (snakes), 5395-hydroxytryptamine and, calcium chan-
nels activated by, coronary artery
(cows), 641
3H-labeled, release, dopamine regulationof, stomach (guinea pigs), 713
motility stimulated by, cyclooxygenase in-hibit.or effects, colon (rats), 742
nonadrenergic bronchodilation and
(cats), 590
Acetylcholinesterase, inhibition, end-platereceptor-channel complex (snakes),
539N-Acetylcysteine, cimetidine and, acet-
aminophen -induced hepatic necrosis(rats), 550
N-Acetyltryptamine, melatonin, receptor,retina (rabbits, chickens), 395
Action potentialcalcium-dependent, dynorphin effects
(mice), 49prolongation, (k.n#{252}�ra toxins and, ax-
ons (crayfish), 307
Adenosine, cardiac effects, atrial and yen-tricular preparations (guinea pigs),766
S-Adenosylmethionine, isoproterenol 0-methylation, aorta (rabbits), 184
Adenylate cycbase, norepinephrine-coupledgenerating system, imipramine andadrenocorticotropin effects on, brain(rats), 409
Adrenoceptoralpha adrenergic
nimodipine effects, saphenotss vein(dogs), 598
postjunctional, intermediate auricularartery (dogs), 698
alpha-i, antagonists, cardiovascular re-flexes (dogs), 456
alpha-i and aLpha-2, peripheral circula-
tion (dogs), 728a�pha-2, saphenous vein contractions, cal-
cium role (dogs), 161Adrenocorticotropin, imipramine and, nor-
epinephrine-coupled cyclic nucleo-tide generating system, brain (rats),409
Age, [3Hjouabain binding, digitalis recep-tore and, skeletal muscle (guinea
pigs), 720Agonist-antagonist interactions, opiate,
three-key drug discrimination proce-dare (pigeons), 81
Airways, nonadrenergic relaxation, neurallymediated, cholinergic mechanismsand (cats), 590
Albuminalpha-i acid glycoprotein and, prazosin
and antipyrine elimination, liver(rats), 636
serum
enzyme-albumin conjugates, chronic
administration (mice), 250polyacryl starch microparticles trap-
ping, immune response (mice), 255Alkadhi, K. A., see Lokhandwala, M. F., 337Allen, T. M., Murray, L., Bhardwaj, D. and
Poznansky, M. J.: cs-Glucosidase-al-bumm conjugates: Effect of chronicadministration in mice, 250
Altiere, R. J., Szarek, J. L. and Diamond,L.: Neurally mediated nonadrenergicrelaxation in cat airways occurs in-
dependent of cholinergic mecha-nisms, 590
Ambrose, J. M., see Silver, P. J., 629
Ameer, B., see Abernethy, D. R., 345
Amine, biogenic, drug-induced changes,brain (rats), 141
p-Aminobenzoic acid, N-acetylation, ge-
netic differences, liver (hamster), 358-y-Aminobutyric acid
antagonists, vasopressin release stimula-tion by (rats), 378
vagal afferent stimulation, sympatheticnerve inhibitory response, effects on(cats), 288
-�-Aminobutyric acid-benzodiazepine chan-nel antagonists, supraspinal convul-sions (rabbits), 274
L-(aS,5S)-a-AminO-3-chlOrO-4,5-dihy-
dro-5-isoxazoleacetic acid, methyl-mercury urinary excretion, effects on(mice), 156
Aminoglycoside
nephrotoxicity, endotoxemia and (rab-bits), 425
renal excretion, nephrectomy and (dogs),90
N-(6-Aminohexyl)-5-chloro- 1 -naphtha-lenesulfonamide, anticahnodulinproperties, artery (rats, rabbits), 476
6-Aminolevulinic acid dehydratase, inhibi-tion by lead, reversal by renal lead-binding protein (rats), 365
Ammonium, quaternary compounds, a�pha-1 acid glycoprotein, binding to, 703
Amnesia, triazolam vs. pentobarbital ef-fects, 120
D-Amphetamine, tetrahydrobiopterin andbiogenic amine concentrations,changes induced by, brain (rats), 141
Analgesia, thiorphan and (rats), 386Anaphylaxis
mediators, collateral ventilation, lung pa-riphery (dogs), 491
slow-reacting substance of, leukotrienereceptors and, lung (guinea pigs), 316
Anemia, hemolytic, propylthiouracil toxic-ity (cats), 13
Angiotensin converting enzyme, pulmonary,
inhibition (rabbits), 372Anion transport, specific inhibition, gossy-
pol and erythrocyte membrane func-tion, 575
Antagonist, see specific type
Antibiotics, nephrotoxicity, endotoxemiaand (rabbits), 425
Antibody, antinuclear, drug-induced (cats),13
Antidepressantsbeta adrenergic receptor/N-protein cou-
pling, cerebral cortex (rats), 30forced swim and, beta adrenergic receptor
down-regulation (rats), 402Antipyrine
elimination, albumin and a�pha-1 acidglycoprotein effects, liver (rats), 636
metabolism, hypoxia and pregnancy ef-fects on, liver (rats), 584
Aortacalcium channels, bepridil hydrochloride
effects (rabbits), 63
contraction inhibition, SQ 29,548 effects(rats), 435
contraction mechanism, calcium ionchannels and phospholipase C (rats),443
isoproterenol, 0-methylation of (rabbits),184
APP-201-533, vascular and cardiac con-tractile protein function, effects on(cows, dogs), 629
Arachidonic acidinfusion, prostaglandin E� and renin
release (dogs), 261
metabolism, diabetes mellitus and (rats),211
metabolites, beta adrenergic responsive-
ness and, coronary artery (cows), 555
Araki, K., see Iwainoto, K., 470Arginine vasopressin, protein phosphoryla-
838 Index Vol. 234
tion mediated by, urinary bladder(toads), 515
AR-L 115 BS, positive inotropic effect, yen-tricular muscle (dogs), 267
Artursson, P., Edman, P. and Sj#{246}holm,I.:Biodegradable microspheres II: Im-mune response to a heterologous andan autobogous protein entrapped inpolyacryl starch microparticles, 255
Asano, M. and Hidaka, H.: Pharmacolog-ical properties of N-(6-aminohexyl)-5-chboro- 1 -naphthalenesulfonam-ide(W-7), a calmodulin antagonist inarterial strips from rats and rabbits,476
Aslanian, W. A., see Wedlund, P. J., 662
Aspirin, antihypertensive effect, inhibition
by metoprolol (rats), 166
Asthma, leukotrienes and, lung (guineapigs), 316
AT-125, see L-(aS,5S)-a-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
Atriumadenosine effects (guinea pigs), 766supersensitivity (rats, guinea pigs), 280
Atropine, nonadrenergic noncholinergic re-laxation, airway (cats), 590
Aucoin, D. P., Peterson, M. E., Hurvitz, A.I., Drayer, D. E., Lahita, R. G.,Quimby, F. W. and Reidenberg, M.M.: Propylthiouracil-induced im-
mune-mediated disease in the cat, 13Auricular artery, intermediate, postjunc-
tional alpha adrenoceptors in (dogs),698
Axon, Goniopora toxin effects on (crayfish),307
Azathioprine, immunosuppression, hepaticoxidative metabolism influence on
(mice), 670
Bahouth, S. W. and Musacchio, J. M.: Spa-cific binding of [3Hjsubstance P to
the rat submaxillary gland. The ef-facts of ions and guanine nucleotides,326
Band 3, gossypol interaction with, erythro-cyte membrane function and, 575
Banziger, V., see Tuttle, R. S., 166
Barakeh, J. F., see Nasseri, A., 350
Barbital, chronic, dependence, abstinenceeffects, cerebellar cyclic GMP system(rats), 569
Barbituratedependence, abstinence effects, cerebellar
cyclic GMP system (rats), 569pentobarbital, triazolam us., 120slow outward current, alterations induced
by (mollusks), 821Barone, S., see Head, R. J., 184
Barorefiex, sympathetic nerve inhibitory re-sponse, vagal afferent stimulation, -y-aminobutyric acid mediation (cats),288�
Barrett, J. E., see Brady, L. S., 106
Bartobome, M. B., see Kuhn, C. M., 204
Behaviorantidepressants and forced swim, beta ad-
renergic receptor down-regulation
(rats), 402locomotor activity, hyperbilirubinemia
and cerebellar proteins (rats), 522nicotine, cocaine and metabolites, effects
on (dogs, monkeys), 106
phencyclidine withdrawal (rats), 415
punished, shock termination and food
presentation (monkeys), 106
self-mutilation, dopamine receptors,functional supersensitivity (rats),447
tolerance, escape titration and (monkeys),94
Bennett, B. M., Brien, J. F., Nakatsu, K.
and Marks, G. S.: Role of hemoglobinin the differential biotransformationof glyceryl trinitrate and isosorbidedinitrate by human erythrocytes, 228
Benowitz, N., see Simon, R. P., 830
Benowitz, N. L. and Jacob, P., III: Nicotinerenal excretion rate influences nico-tine intake during cigarette smoking,153
Benson, L. M., see Abraham, R. T., 670Benzodiazepine
antagonists, supraspinal convulsions in-
duced by (rabbits), 274triazolam, pentobarbital us., 120
Ben-Zvi, Z., see Garty, M., 391Bepridil hydrochloride
antiarrhythmic and electrophysiologic ef-fects, myocardal ischemia and infarc-tion (dogs), 72
calcium channels, effects on, vascular
smooth muscle of aorta (rabbits), 63Berti, F., see Sautebin, L., 217Bethanechol, nonadrenergic noncholinergic
relaxation, airway (cats), 590Bhardwaj, D., see Allen, T. M., 250B-HT 920, nimodipine and, saphenous vein
(dogs), 598Bicuculline, vasopressin release stimulated
by (rats), 378Bladder, protein phosphorylation, vasopres-
sin-mediated (toads), 515Blanquet, F., Bouvier, M. and Gonella, J.:
Action of trimebutine in cat and rab-bit colon: Evidence of an opioid-likeeffect, 708
Blockade, reticuloendothelial, enzyme-al-bumin conjugates, chronic adininis-tration effects (mice), 250
Blood flow, liver, propranobol clearance, car-bon tetrachloride effects (rats), 470
Blood pressuredopamine and bromocriptine effects, neu-
ronal and postjunctional componentsof (rabbits), 681
sympathetic nerve inhibitory response,vagal afferent stimulation, �y-amino-butyric acid mediation (cats), 288
Bone, mobilization, glucopyranoside effects(rats), 25
Bone marrow, cell cycle kinetics, alterationby diphenylhydantoin (mice), 57
Boorman, G. A., see Tucker, A. N., 57Bouvier, M., see Blanquet, F., 708Bowman, K. F., see Riviera, J. E., 90
Boyd, M. R., see Kramer, R. A., 498Boyer, I. J., Cory-Slechta, D. A. and Di-
Stefano, V.: Lead induction of cropdysfunction in pigeons through a di-rect action on neural or smooth mus-cle components of crop tissue, 607
Boyer, I. J. and DiStefano, V.: An investi-gation of the mechanism of lead-in-duced relaxation of pigeon cropsmooth muscle, 616
Brady, L. S. and Barrett, J. E.: Effects ofserotonin receptor antagonists on
punished responding maintained by
stimulus-shock termination or food
presentation in squirrel monkeys,106
Brainmarijuana binding sites (rats), 784muscarinic cholinergic receptors from,
[3H]pirenzepine binding to (rats), 37pentylenetetrazol concentrations, infu-
sion rate effects on, convulsions(rats), 624
phenobarbital uptake, blood-brain pHgradient influence on, status epilep-ticus (rats), 830
Branch, R. A., see Wedlund, P. J., 662Breese, G. R., Napier, T. C. and Mueller, R.
A.: Dopamine agonist-induced loco-motor activity in rats treated with 6-hydroxydopamine at differing ages:
Functional supersensitivity of D-1dopamine receptors in neonatally le-sioned rats, 447
Breese, G. R., see Duncan, G. E., 402
Brian, J. F., see Bennett, B. M., 228Broadley, K. J., MacLeod, K. M., Rodgers,
R L. and McNeil, J. H.: Regionaldifferences in the responses ofguinea-pig cardiac tissue to carbacholand their potentiation by hypother-mia, 222
Bromocriptine, blood pressure effects, neu-ronal and postjunctional components(rabbits), 681
Bronchodilation, nonadrenergic, acetylcho-
line and (cats), 590
Brouwer, K. L. R and Vore, M.: Effect ofhypoxia and pregnancy on antipyrinemetabolism in isolated perfused ratlivers, 584
Brown, J. A., see Marrazzi, M. A., 804Bruckner, R, Fenner, A., Meyer, W., Nobis,
T.-M., Schmitz, W. and Scholz, H.:Cardiac effects of adenosine andadenosine analogs in guinea-pigatrial and ventricular preparations:Evidence against a role ofcyclic AMPand cyclic GMP, 766
Buthionine sulfoximide, 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-ni-trosourea nephrotoxicity, effects on(rats), 498
Caffeine, calcium overload induced by, re-versal, Purkinje fibers (dogs), 172
Calciumantagonist
vascular and cardiac contractile proteinfunction, effects on (cows, dogs), 629
vasodepressor effects (dogs), 728conductance, kappa opioid effects (mice),
49dopamine release dependent on, mela-
tonin and, retina (rabbits, chickens),395
entry blocker, alpha adrenergic activationinhibition, saphenous vein (dogs),598
extracellular, saphenous vein contrac-tions and, a�pha-2 adrenoceptors(dogs), 161
fluxes, W-7 effects, vascular smooth mus-cle (rats, rabbits), 476
overload, caffeine-induced, reversal, Pur-kinje fibers (dogs), 172
surface membrane bound, displacement,skeletal muscle (frogs), 233
Index 8391985
transport, glucopyranoside effects (rats),25
Calcium channelacetylcholine- and 5-hydroxytryptamine-
activated, coronary artery (cows), 641
antagonist, myocardial calcium and p0-tassium channel blocking (frogs), 134
blockers, beta receptors, heart, 561potential-dependent and receptor-oper-
ated, bepridil hydrochloride effects,vascular smooth muscle ofaorta (rab-bits), 63
Calcium ionionophore A23187, leukotriene release
and, lung parenchyma, 217
voltage-dependent channels, 5-hydroxy-tryptamine receptor-mediated aorta
contraction (rats), 443
Calmodulinantagonist, N-(6-aminohexyl)-5-chloro-
1-naphthalenesulfonamide (rats,rabbits), 476
vascular and cardiac contractile proteinfunction (cows, dogs), 629
Cannabinoid, binding sites, brain (rats), 784
Cannabis, binding sites, brain (rats), 784
Caporali, M. G., see Massotti, M., 274Captopril, angiotensin converting enzyme
inhibition induced by, kinetics (rab-
bits), 372
Carbachol, cardiac tissue responses to, po-tentiation by hypothermia (guineapigs), 222
Carbon tetrachloride, chronic, reduced he-patic propranolol clearance (rats),
470Cardiotonics, vascular and cardiac contract-
ile protein function, effects on (cows,dogs), 629
Cardiovascular system
contractile proteins, calcium antagonisteffects on (cows, dogs), 629
dopamine receptors, SKF 82526 and
(dogs), 337
reflex tachycardia, alpha-i adrenoceptorantagonists (dogs), 456
renal nerve activity suppression, methio-nine enkephalin (rabbits), 534
Carter, R. B. and Dykstra, L. A.: Effects ofpicenadol (LY150720) and its ster-eoisomers on electric shock titrationin the squirrel monkey, 299
Cassis, L. A., see Goto, K., 280
Cassis, L. A., Stitzel, R. E. and Head, R. J.:Hypernoradrenergic innervation ofthe caudal artery of the sponta-neously hypertensive rat: An influ-ence upon neuroeffector mecha-nisms, 792
Catalepsy, met.aphit effects on (pigeons),
648
Catecholamine, detection, atrium (rats,guinea pigs), 280
Catechol-0-methyltransferase, isoprotere-
nol and, aorta (rabbits), 184
Caudal artery
hypernoradrenergic innervation, sponta-neous hypertension (rats), 792
postjunctional supersensitivity, reser-pine-induced, alpha adrenergic recep-tors and (rats), 350
Cell cycle, kinetics, bone marrow, alterationby diphenylhydantoin (mice), 57
Central nervous system, see Nervous system
Cephalosporin, nephrotoxicity, endotox-emia and (rabbits), 425
Cerebellumcyclic GMP, barbital tolerance develop-
ment, subsequent abstinence and,cerebellum (rats), 569
hypoplasia, bilirubin neurotoxicity and
(rats), 522Cerebral cortex
beta adrenergic receptor/N-protein cou-pling, clenbuterol and antidepressantdrugs (rats), 30
cyclic GMP, barbital tolerance develop-ment, abstinence effects, cerebellum(rats), 569
Cerebrospinal fluid, pentylenetetrazol con-centrations, infusion rate effects on,convulsions (rats), 624
Chiba, S., see Ito, T., 698Chimeric toxin, binding, cholinergic neuro-
muscular junction (mice), 100
1-(2-Chloroethyl)-3-(trans-4-methylcyclo-
hexyl)-1-nitrosourea, nephrotoxicity,buthionine sulfoximime effects on(rats), 498
Chuang, D.-M., see Nakaki, T., 442
Cigarette smoking
abuse liability and pharmacodynamiccharacteristics, 1
nicotine intake, renal clearance and, 153Cimetidine, N-acetylcysteine and, acet-
aniinophen-induced hepatic necrosis(rats), 550
Cinnarizine, vascular and cardiac contract-ile protein function, effects on (cows,dogs), 629
Cirazoline, nimodipine and, saphenous vein
(dogs), 598Cisapride, motor-stimulating properties,
gastrointestinal (guinea pigs), 775
Clark, M. A., see Mong, S., 316Clausen, T., see Kjeldsen, K., 720Clenbuterol, beta adrenergic receptor/N-
protein coupling, cerebral cortex
(rats), 30Clonidine
a’pha adrenoceptors and, intermediate
auricular artery (dogs), 698
kappa opioids vs. , diuresis and vasopressinsuppression (rats), 463
tolerance, escape titration and (monkeys),94
Cocaine
behavioral effects (dogs, monkeys), 106
tetrahydrobiopterm and biogenic amineconcentrations, changes induced by,brain (rats), 141
Colonelectromyogram, trimebutine effects
(cats, rabbits), 708motility, cycbooxygenase inhibitor effects
(rats), 742Cone, E. J., see Risner, M. E., 113
Conn, P. J. and Sanders-Bush, E.: Seroto-nm-stimulated phosphoinositideturnover: Mediation by the S� bind-ing site in rat cerebral cortex but notin subcortical regions, 195
Contraception, gossypol, erythrocyte mem-
brane function and, 575Contractile force, caffeine-induced calcium
overload, Purkinje fibers (dogs), 172Convulsion
pentylenetetrazol infusion rate and, se-
rum, brain and cerebrospinal fluid(rats), 624
spontaneous, barbital tolerance develop-ment, abstinence effects, cerebellarcyclic GMP system (rats), 569
supraspinal, benzodiazepine antago-nist-induced (rabbits), 274
Cooke, J. P., Rimele, T. J., Flavahan, N. A.and Vanhoutte, P. M.: Nimodipineand inhibition ofa�pha adrenergic ac-tivation of the isolated canine saphe-nous vein, 598
Copeland, J., see Simon, R. P., 830
Corn, R. E., see Haspel, H. C., 575Coronary artery
arachidonic acid metabolites in, beta ad-renergic responsiveness and (cows),555
calcium channels, acetylcholine- and 5-hydroxytryptamine-activated (cows),
641
Corticotropin releasing factor, tetrahydro-biopterin and biogenic amine concen-trations, changes induced by, brain(rats), 141
Cory-Slechta, D. A., see Boyer, I. J., 607
Costa, E., see Nakaki, T., 442
Cotinine, behavioral effects (dogs, mon-keys), 106
Crivellari, M. T., see Sautebin, L., 217Crooke, S. T., see Mong, S., 316Crop
neural or smooth muscle components,
lead-induced dysfunction (pigeons),607
smooth muscle, lead-induced relaxation(pigeons), 616
Current, slow outward, barbiturate-induced
alterations (mollusks), 821Cyclic AMP
bilirubin neurotoxicity, cerebellar pro-teins and (rats), 522
cardiac effects, atrial and ventricularpreparations (guinea pigs), 766
norepinephrine-coupled generating sys-tem, imipramine and adrenocortico-tropin effects on, brain (rats), 409
phosphodiesterase inhibition, ventricular
muscle (dogs), 267SQ 29,548 effects, platelets (humans,
guinea pigs, rats), 435vasopressin-mediated protein phosphor-
ylation and, urinary bladder (toads),515
Cyclic GMPbarbital tolerance, development, subse-
quent abstinence and, cerebellum(rats), 569
bilirubin neurotoxicity, cerebellar pro-
teins and (rats), 522cardiac effects, atrial and ventricular
preparations (guinea pigs), 766Cycbooxygenase
beta adrenergic responsiveness and, ar-achidonic acid metabolite effects on,coronary artery (cows), 555
inhibitors, Met-enkephalin- and acetyl-choline-stimulated motility, effectson, colon (rats), 742
SQ 29,548 effects, platelets (humans,guinea pigs, rats), 435
Cytochrome P-450, inhibition, cimetidine
effects, acetaminophen-induced hep-atotoxicity (rats), 550
840 Index VoL 234
Dachiw, J., see Silver, P. J., 629Dawson, J. R., Weitering, J. G., Mulder, G.
J., Stillwell, R. N. and Pang, K. S.:Alteration of transit time and direc-
tion of flow to probe the heteroge-neous distribution of conjugating ac-tivities for harmol in the perfused ratliver preparation, 691
De Cou#{235}t,G., see Dumont, M., 239Deguchi, N., see Iwamoto, K., 470de la Lande, I. S., see Head, R. J., 184
Desmopressin
diuresis and, kappa opioids (rats), 463peroral, diabetes insipidus, 754
Diabetes insipidus, peroral treatment, des-mopressin, 754
Diabetes mellitus, arachidonic acid metab-olism, urinary prostaglandin andthromboxane excretion (rats), 211
Diamond, L., see Altiere, R. J., 590
Digitalis receptors, see ReceptorDigoxin
3H-labeled, binding, digitalis receptors
and, skeletal muscle (guinea pigs),720
renal clearance, spironolactone effects(dogs), 190
Dihydroergotamine, liver uptake, trolean-domycin effects (rats), 239
Diltiazem
calcium channels, effects on, vascularsmooth muscle of aorta (rabbits), 63
vasodepressor effects (dogs), 728verapamil and, coronary artery contrac-
tion (cows), 641
Dimethylpropranolol, ventricular muscles,electrophysiobogy (guinea pigs), 507
DiMicco, J. A., see Wible, J. H., Jr., 378Diphenylhydantoin, bone marrow cell cycle
kinetics, alteration by (mice), 57DiStefano, V., see Boyer, I. J., 607DiStefano, V., see Boyer, I. J., 616Diuresis, vasopressin suppression and,
kappa opioids (rats), 463
Diurnal rhythms, tetrahydrobiopterin andbiogenic amine concentrations, drug-induced changes, brain (rats), 141
Domino, E. F., see Koek, W., 648
Domperidone[3H]acetylcholine release, dopamine reg-
ulation of, stomach (guinea pigs), 713
dopamine and, blood pressure (rabbits),681
Dopamine[3Hjacetylcholine release, regulation by,
stomach (guinea pigs), 713blood pressure effects, neuronal and post-
junctional components (rabbits), 681calcium-dependent release, melatonin
and, retina (rabbits, chickens), 3956-hydroxy, locomotor activity and, flee-
nate and adult (rats), 447receptors, see Receptor
Dorsal root ganglion neuron, action poten-tial duration, dynorphin and neoen-dorphin peptide effects (mice), 49
Drack, E., see Scheurer, U., 742Drayer, D. E., see Aucoin, D. P., 13Drug abuse
nicotine, abuse liability and pharmaco-dynamic characteristics, 1
triazolam vs. pentobarbital, 120Drug dependence
agonist-antagonist interactions (pigeons),
81
barbital, abstinence effects, cerebellarcyclic GMP system (rats), 569
phencyclidine (rats), 415
Drug discrimination, lysergic acid diethyl-amide, serotonin agonists and antag-onists (monkeys), 244
Drug metabolism, polymorphic, mepheny-thin, normal subjects, 662
Drug tolerance, methadone, neuroendocrinefunction and (rats), 204
Dubocovich, M. L.: Characterization of aretinal melatonin receptor, 395
Duman, R. S., Strada, S. J. and Enna, S. J.:Effect of imipramine and adrenocor-ticotropin administration on the ratbrain norepinephrine-coupled cyclicnucleotide generating system: Alter-
ations in a4.�ha and beta adrenergic
components, 409Dumont, M., De Cou#{235}t,G., Le Bigot, J.-F.
and Erlinger, S.: Mechanism of up-take of dihydroergotamine by iso-lated rat hepatocytes: Effect of tro-leandomycin, 239
Duncan, G. E., Paul, I. A., Harden, T. K.,Mueller, R. A., Stumpf, W. E. andBreese, G. R: Rapid down regulationof beta adrenergic receptors by corn-bini’ng antidepressant drugs withforced swim: A model of antidepres-sant-induced neural adaptation, 402
Dykstra, L. A., see Carter, R B., 299
Dynorphincalcium-dependent action potential du-
ration, effects (mice), 49infusion into substantia nigra, maximal
electroshock seizure protection(rats), 45
Ear, artery, a4�lza adrenoceptors in (dogs),698
Edman, P., see Artursson, P., 255
Edrophonium, physostigmine and methane-sulfonyl fluoride, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539
Edvinsson, L., see Wahlestedt, C., 735Effeney, D. J., see Wasehek, J. A., 431Ekblad, E., see Wahlestedt, C., 735Electrical control activity, migrating my-
oelectric complex, morphine, intes-tine (dogs), 814
Electrical field stimulation, airways (cats),590
Electrical response activity, migrating my-oelectric complex, morphine, intes-tine (dogs), 814
Electrolyte, reabsorption, acetazolamide in-
hibitory effects, kidney tubules(dogs), 747
Electromyogram, trimebutine effects, colon(cats, rabbits), 708
Electroshockseizure, protection, opiate infusion into
substantia nigra (rats), 45titration, picenadol effects (monkeys),
299
Enalapril, angiotensin converting enzymeinhibition induced by, kinetics (rab-bits), 372
Endoh, M., Yanagisawa, T., Morita, T. andTaira, N.: Differential effects of sul-mazole (AR-L 115 BS) on contractileforce and cyclic AMP levels in canine
ventricular muscle: Comparison withMDL 17,043, 267
Endotoxemia, antibiotic nephrotoxicityaugmentation by (rabbits), 425
Endotoxin, renal injury and, antibioticnephrotoxicity (rabbits), 425
Enkephalin, cycbooxygenase inhibitors and,interaction, colon (rats), 742
Enkephalinase A, thiorphan and analgesia(rats), 386
Enna, S. J., see Duman, R. S., 409Ensinger, H., Majewski, H., Hedler, L. and
Starke, K.: Neuronal and postjunc-tional components in the blood pros-sure effects of dopamine and bromo-criptine in rabbits, 681
Epilepsy, opiate infusion into substantia ni-gra and (rats), 45
Erlinger, S., see Dumont, M., 239Erythrocyte
glyceryltrinitrate and isosorbide dinitratebiotransformation, hemoglobin rolein, 228
membrane function, gosaypol effects on,575
Escape titration, drug tolerance and (mon-keys), 94
Eulie, P. J., see Rhee, H. M., 534
Evanich, M. J., Sander, G. E, Rice, J. C.and Giles, T. D.: Ventilatory re-sponse to intravenous methionine
enkephalin in awake dogs, 677
Fenner, A., see Bruckner, R., 766
Ferguson, R. J., see Hein, D. W., 358
Fibrillation, ventricular, bepridil effects
(dogs), 72Fiekers, J. F.: Interactions of edrophonium,
physostigmine and methanesulfonylfluoride with the snake end-plate ace-tylcholine receptor-channel complex,539
Fielding, R. M., see Wasehek, J. A., 431Fiori, F., see #{248}ie,S., 636Flaim, S. F., Ratz, P. H., Swigart, S. C. and
Gleason, M. M.: Bepridil hydrochlo-ride alters potential-dependent andreceptor-operated calcium channelsin vascular smooth muscle of rabbitaorta, 63
Flaim, S. F., see Ratz, P. H., 641
Flavahan, N. A., see Cooke, J. P., 598Fleming, W. W., see Goto, K., 280
Fluorescence, catecholamine detection,atrium (rats, guinea pigs), 280
Folate, bone marrow cell cycle kinetics and,diphenyihydantoin effects (mice), 57
Folco, G., see Sautebin, L., 217Forced swim test, antidepressants and, beta
adrenergic receptor down-regulation
(rats), 402Fowler, B. A., see Goering, P. L., 365
France, C. P. and Woods, J. H.: Opiateagonist-antagonist interactions: Ap-plication of a three-key drug discrim-ination procedure, 81
Frank, G. B., see Shetty, S. S., 233Fraser, A., see O’Donnell, J. M., 30Frederickson, R. C. A., see Mendelsohn, L
G., 386Fujiwara, M., see Muramatsu, I., 307
�9-Funaltrexamine, vasopressin suppressionand (rats), 463
Gale, K., see Garant, D. S., 45
1985 Index 841
Galli, G., see Sautebin, L., 217Garant, D. S. and Gale, K.: Infusion of
opiates into substantia nigra protects
against maximal electroshock sei-zures in rats, 45
Garty, M., Ben-Zvi, Z. and Hurwitz, A.:Opioid effects on lidocaine disposi-tion and toxicity in mice, 391
Gastrointestinal tract, cisapride, motor-
stimulating properties (guinea pigs),775
Gatta, F., see Massotti, M., 274Gawronska-Szklarz, B., see Rane, A., 761
Genetics, N-acetylation differences, liver(hamster), 358
Gentamicin, decreased fractional renal ex-cretion, nephrectomy and (dogs), 90
Gibson, T. P., see O’Brien, M. S., 190
Gibes, T. D., see Evanich, M. J., 677Gillis, C. N., see Moalli, R., 372Gleason, J. G., see Mong, S., 316Gleason, M. M., see Flaim, S. F., 633fi-D-Glucopyranosides, vitamin D com-
pounds, biologic activity (rats), 25a-Glucosidase-albumin, conjugates, chronic
administration, effects (mice), 250
Glucostat, “gold thioglucose-lesioned,” thio-glucose and, interactions (mice), 804
Glucuronidation, inhibition, probenecid,345
Glutathionebiosynthesis, 1-(2-chloroethyl)-3-(trans-
4-methylcyclohexyl)- 1 -nitrosoureaeffects, buthionine sulfoximide and(rats), 498
reduced, leukotriene formation and, lungparenchyma, 217
urinary excretion, L-(aS,5S)-a-aminO-3-chloro-4,5-dihydro-5-isoxazoleacetic
acid effects (mice), 156Glyceryl trinitrate, biotransformation by
erythrocytes, hemoglobin role in, 228Glycoprotein
alpha-i acid, prazosin and antipyrineelimination, liver (rats), 636
alpha-i acid and asialo a�pha-1 acid, cat-ion binding, 703
Glycoside, vitamin D analogs, biologic ef-fects (rats), 25
Goering, P. L. and Fowler, B. A.: Mecha-nism of renal lead-binding proteinreversal of �-aminolevulinic acid de-hydratase inhibition by lead, 365
Goldberg, S. R., see Risner, M. E., 113Gold thioglucose, glucostat lesioned by,
thioglucose and, interactions (mice),804
Gonella, J., see Blanquet, F., 708
Goniopora toxin, axons, effects on (cray-fish), 307
Gosselin, R. E., see Weselcouch, E. 0., 19Gossypol, erythrocyte membrane function,
effects on, 575Goto, K., Longhurst, P. A., Cassis, L. A.,
Head, R. J., Taylor, D. A., Rice, P. J.and Fleming, W. W.: Surgical sym-pathectomy of the heart in rodentsand its effect on sensitivity to ago-nists, 280
Grassi, E., see Sautebin, L., 217Greenberg, R., see Ogletree, M. L., 435
Greenblatt, D. J., see Abernethy, D. R., 345
Griffiths, R. R., see Roache, J. D., 120Gross, M., see Londowski, J. M., 25
G-substrate, bilirubin neurotoxicity and(rats), 522
Guanine, nucleotides, [3H]substance Pbinding, submaxillary gland (rats),326
H#{224}kanson, R., see Wahlestedt, C., 735Haloperidol, [3H]acetylcholine release, do-
pamine regulation of, stomach(guinea pigs), 713
Halter, F., see Scheurer, U., 742
Hammer, M. and Vilhardt, H.: Peroraltreatment of diabetes insipidus witha polypeptide hormone analog, des-mopressin, 754
Hansen, 0., see Kjeldsen, K., 720
Harden, T. K., see Duncan, G. E., 402Harmol, conjugation, transit time and flow
direction alteration, effects on, liver
(rats), 691Harris, D. N., see Ogletree, M. L., 435
Hart, J. C., see Leander, J. D., 463
Hartmann, A., see Langberg, H., 747Hashish, cannabinoid binding sites, brain
(rats), 784Haslanger, M. F., see Ogletree, M. L., 435Haspel, H. C., Corin, R. E. and Sonenberg,
M.: Effect of gossypol on erythrocyte
membrane function: Specific inhibi-tion of inorganic anion exchange andinteraction with band 3, 575
Head, R., see Koek, W., 648Head, R. J., Irvine, R. J., Barone, S., Stitzel,
R. E. and de la Lande, I. S.: Nonin-tracellular, cell-associated 0-meth-ylation of isoproterenol in the iso-
lated rabbit thoracic aorta, 184
Head, R. J., see Cassis, L. A., 792Head, R. J., see Goto, K., 280
Heartbeta-i and beta-2 adrenergic receptors, co-
existence in, 561carbachol effects, potentiation by hypo-
thermia (guinea pigs), 222digitalis receptors, [3Hjouabain distribu-
tion (guinea pigs), 720electrophysiology, myocardial Ca� and
K� channel blocking (frogs), 134Purkinje fibers, see Purkinje fibersrate, urapidil and prazosin effects (dogs),
456sympathectomy, sensitivity to agonists
and (rats, guinea pigs), 280transcapillary solute transport (rabbits),
19ventricles
adenosine effects (guinea pigs), 766contractile force and cyclic AMP levels
(dogs), 267electrophysiology, dimethylpropranobol
effects (guinea pigs), 507tachycardia and fibrillation, bepridil ef-
fects (dogs), 72Hedberg, A., Kempf, F., Jr., Josephson, M.
E. and Molinoff, P. B.: Coexistenceofbeta-i and beta-2 adrenergic recep-tors in the human heart: Effects oftreatment with receptor antagonistsor calcium entry blockers, 561
Hedler, L., see Ensinger, H., 681Hedlund, R, see Simon, R P., 830
Hem, D. W., Kirlin, W. G., Ferguson, R. J.and Weber, W. W.: Biochemical in-vestigation ofthe basis for the genetic
N-acetylation polymorphism in theinbred hamster, 358
Hemicholinium, nonadrenergic inhibitorysystem, lung (cats), 590
Hemoglobin, biotransformation, organic ni-trates, 228
Henningfield, J. E., Miyasato, K. and Jas-inski, D. R.: Abuse liability and phar-macodynamic characteristics of in-travenous and inhaled nicotine, 1
Hepatocyte, dihydroergotamine uptake, tro-leandomycin effects (rats), 239
Hepatotoxicity, acetaminophen, cimetidineand N-acetylcysteine effects (rats),550
Hexamethonium, nonadrenergic noncholin-ergic relaxation, airway (cats), 590
Hidaka, H., see Asano, M., 476Hisaoka, M. and Levy, G.: Kinetics of drug
action in disease states. XIII. Effectof dialyzable component(s) of uremicblood on phenobarbital concentra-tions in rats at onset of loss of right-ing reflex, 180
Histamine
airway reactivity to (dogs), 491capillary permeability and, myocardium
(rabbits), 19receptors, see Receptor
Hoffman, B. B., see Lurie, K. G., 147
Holsztynska, E. J., see Koek, W., 648
Hong, L., see Thcker, A. N., 57Howell, R. E., see Moalli, R., 372
Hsu, C.-Y., see Tune, B. M., 425Huguenard, J. R. and Wilson, W. A.: Bar-
biturate-induced alterations in thekinetic parameters of slow outwardcurrent in Aplysia giant neurons, 821
Hume, J. R.: Comparative interactions oforganic Ca� channel antagonistswith myocardial Ca4� and K� chan-nels, 134
Humphrey, S. J. and McCall, R. B.: Evi-dence for �y-aminobutyric acid media-tion of the sympathetic nerve inhib-itory response to vagal afferent stim-
ulation, 288Hurvitz, A. I., see Aucoin, D. P., 13Hurwitz, A., see Garty, M., 391Hydrolysis, phosphoinositide, serotonin-
stimulated (rats), 1956-Hydroxydopamine, see Dopamine5-Hydroxytryptamine, see Serotonin
Hyperbiirubinemia, cerebellar proteins and(rats), 522
Hyperinnervation, caudal artery, sponta-neous hypertension and (rats), 792
Hypersensitivity diseases, leukotriene re-
ceptors and smooth muscle contrac-tion, lung (guinea pigs), 316
Hypertension
spontaneous
aspirin antihypertensive effect, meto-probol inhibition of (rats), 166
hypernoradrenergic innervation, caudal
artery (rats), 792Hypoplasia, cerebellar, bilirubin neurotox-
icity and (rats), 522Hypothermia, cardiac tissue response to
carbachol, potentiation by (guineapigs), 222
Hypoxia, pregnancy and, antipyrine metab-olism, liver (rats), 584
Imipramine
842 Index Vol.234
adrenocorticotropin and, norepinephrine-coupled cyclic nucleotide generatingsystem, brain (rats), 409
forced swim and, beta adrenergic receptordown-regulation (rats), 402
Immune function, bone marrow cell cyclekinetics, diphenylhydantoin effects(mice), 57
Immune response, trapped protein (mice),255
Indomethacin, beta adrenergic responsive-ness, arachidonic acid metabolite ef-fects on, coronary artery (cows), 555
Infarction, myocardial, bepridil effects(dogs), 72
Intestine
absorption, desmopressin and diabetes in-sipidus, 754
migrating myoelectric complex, biphasic
response to morphine (dogs), 814Inulin, permeability-surface area products,
transcapillary transport, myocar-dium (rabbits), 19
Ions, [3Hjsubstance P binding, effects on,submaxillary gland (rats), 326
Iprindole, forced swim and, beta adrenergicreceptor down-regulation (rats), 402
Irvine, R. J., see Head, R. J., 184Ischemia, myocardial, bepridil effects
(dogs), 72
Isometric tension, bepridil hydrochloride,effects on calcium channels, vascularsmooth muscle of aorta (rabbits), 63
Isoniazid, N-acetylation, genetic differ-
ences, liver (hamster), 358
Isoproterenol, capillary permeability and,myocardium (rabbits), 19
Isosorbide dinitrate, biotransformation byerythrocytes, hemoglobin role in, 228
Ito, T. and Chiba, S.: Existence of two typesof postjunctional a�pha adrenocep-
tors in the isolated canine interme-diate auricular artery, 698
Iwamoto, K., Watanabe, J., Araki, K., Se-toh, M. and Deguchi, N.: Reducedhepatic clearance of propranolol in-duced by chronic carbon tetrachlo-ride treatment in rats, 470
Jacob, P., III, see Benowitz, N. L., 153
Jacobson, A. E., see Koek, W., 648Jacqz, E., see Wedlund, P. J., 662
Janasen, P. A. J., see Schuurkes, J. A. J.,775
Jardine, I., see Abraham, R. T., 670Jasinski, D. R., see Henningfield, J. E., 1
Jim, K. F. and Matthews, W. D.: Role of
extracellular calcium in contractionsproduced by activation of postsyn-aptic a�pha-2 adrenoceptors in thecanine saphenous vein, 161
Johnson, B. G., see Mendelsohn, L. G., 386Josephson, M. E., see Hedberg, A., 561
Junction potentials, colon electromyogram,trimebutine effects (cats, rabbits),708
Kadowitz, P. J., see Spannhake, E. W., 491
KB-944, vasodepressor effects (dogs), 728Kempf, F., Jr., see Hedberg, A., 561
Kidneydigoxin clearance, spironolactone effects
(dogs), 190
disease, aminoglycoside excretion, ne-phrectomy and (dogs), 90
failure, phenobarbital and uremia (rats),180
lead-binding proteins, �-aminolevulinic
acid dehydratase inhibition reversal(rats), 365
nephrotoxic injury, antibiotics and (rab-bits), 425
nicotine clearance, nicotine intake and,153
prostaglandins E,� and E�, metoprolol andaspirin antihypertensive effects(rats), 166
tubules, electrolyte reabsorption, acet-azolamide inhibitory effects (dogs),
747
Kiil, F., see Langberg, H., 747
Kiil, F., see Vikse, A., 261Kinzig, C. M., see Mong, S., 316Kirlin, W. G., see Hem, D. W., 358Kjeldsen, K., N#{248}rgaard, A., Hansen, 0. and
Clausen, T.: Significance of skeletalmuscle digitalis receptors for[3Hjouabain distribution in the
guinea pig, 720Kleeberger, S. R., see Spannhake, E. W.,
491Klingman, G. I., see Spain, J. W., 415Kodama, I., Kondo, N., Shibata, S. and Ya-
made, K.: Effects of dimethylpro-
pranolol (UM-272) on the electro-physiological properties of guinea-pigventricular muscles, 507
Koek, W., Head, R., Holsztynska, E. J.,Woods, J. H., Domino, E. F., Jacob-son, A. E., Rafferty, M. F., Rice, K.C. and Lessor, R. A.: Effects of me-taphit, a proposed phencyclidine(PCP) receptor acylator, on catalepsyin pigeons, 648
Kondo, N., see Kodama, I., 507Konieczkowski, M. and Rudolph, S. A.:
Vasopressin-mediated protein phos-phorylation in intact toad urinary
bladder, 515Kost, S. B., see Londowski, J. M., 25
Kostyniak, P. J., see Mulder, K. M., 156
Kramer, R. A., Schuller, H. M., Smith, A.C. and Boyd, M. R: Effects of buth-ionine sulfoximine on the nephrotox-icity of 1-(2-chloroethyl)-3-(trans-
4-methylcyclohexyl)-1-nitrosourea
(MeCCNU), 498Kuhn, C. M. and Bartolome, M. B.: Effect
of chronic methadone administrationon neuroendocrine function in youngadult rats, 204
Kumar, R., see Londowski, J. M., 25
Kusunoki, M., Taniyama, K. and Tanaka,C.: Dopamine regulation of[3H]acetylcholine release fromguinea-pig stomach, 713
Labler, L., see Londowski, J. M., 25Lahita, R. G., see Aucoin, D. P., 13Lane, S. J. and Morgan, W. W.: Develop-
ment of tolerance to chronic barbital
treatment in the cerebellar cyclic
guanosine monophosphate systemand its response to subsequent bar-bital abstinence, 569
Lang, I. M., see Sarna, S. K., 814Langberg, H., Hartmann, A. and Kiil, F.:
Inhibitory effect of acetazolamide onrenal tubular reabsorption of
NaHCO3 and NaC1 in dogs variesinversely with plasma pH, 747
Lanthanum, surface membrane bound cal-cium, displacement, skeletal muscle(frogs), 233
Lead6-aminolevulinic acid dehydratase inhi-
bition, reversal, renal lead-bindingprotein (rats), 365
crop dysfunction induced by (pigeons),607
relaxation induced by, crop smooth mus-dc (pigeons), 616
Leander, J. D., Zerbe, R. L and Hart, J. C.:Diuresis and suppression of vasopres-
sin by kappa opioids: Comparisonwith mu and delta opioids and cloni-dine, 463
Le Bigot, J.-F., see Dumont, M., 239Lee, E. H. Y. and Mandell, A. J.: Relation-
ships between drug-induced changesin tetrahydrobiopterin and biogenicamine concentrations in rat brain,141
Lesch-Nyhan disease, dopamine receptors,functional supersensitivity (rats),
447Lessor, R A., see Koek, W., 648Leukotriene
C4 and D4, beta adrenergic responsivenessand, coronary artery (cows), 555
receptors, see Receptor
release pattern, lung parenchyma, 217Levy, G., see Hisaoka, M., 180Levy, G., see Ramzan, I. M., 624
Lewis, M. A., see Mong, S., 316Lidocaine, disposition and toxicity, opioid
effects (mice), 391Light reflex, pupillary, morphine effects
(cats), 603
Lindup, W. E., see Rosenbaum, S. E., 485Lipoxygenase, beta adrenergic responsive-
ness and, arachidonic acid metaboliteeffects on, coronary artery (cows),555
LiverN-acetylation, genetic differences (ham-
star), 358antipyrine metabolism, hypoxia and preg-
nancy effects on (rats), 584blood flow, see Blood flowdihydroergotamine uptake, troleandomy-
cm effects (rats), 239harmol conjugation, transit time and flow
direction alteration, effects on (rats),691
injury, carbon tetrachioride-induced, re-duced propranolol clearance (rats),470
necrosis, acetaminophen-induced, cimet-idine and N-acetylcysteine effects(rats), 550
oxidative metabolism, immunosuppres-
sive activities of 6-thiopurines(mice), 670
prazosin and antipyrine elimination, al-bumin and alpha-i acid glycoproteineffects (rats), 636
Lokhandwala, M. F., Watkins, H. 0., Se-bouni, M. H. and Alkadhi, K. A.:Pharmacological analysis of the ac-tions ofSKF 82526 on cardiovasculardopamine receptors, 337
Londowski, J. M., Kost, S. B., Gross, M.,Labler, L., Meier, W. and Kumar, R.:
1985 Index 843
Biologic activity of 3$-D-glucopyran-osides of vitamin D compounds, 25
Longhurst, P. A., see Goto, K., 280Lorazepam, clearance, probenecid impair-
meat of, 345Lucantom, D., see Massotti, M., 274Lucchesi, B. R., see Lynch, J. J., 72
Lucchesi, K. J., see Weselcouch, E. 0., 19Luneau, C. J., see Weselcouch, E. 0., 19Lung
compliance, in vivo measurements (dogs),491
metabolism, angiotensin converting en-zyme inhibition (rabbits), 372
nonadrenergic noncholinergic inhibitorysystem, 590
parenchyma, leukotriene release patterns,217
smooth muscle contraction, leukotrienereceptors and (guinea pigs), 316
Lurie, K. G., Tsujimoto, G. and Hoffman,B. B.: Desensitization of a�pha-1 ad-renergic receptor-mediated vascularsmooth muscle contraction, 147
Luster, M. I., see Tucker, A. N., 57
Luthin, G. R. and Wolfe, B. B.: Characteri-zation of [3Hjpirenzepine binding to
muscarinic cholinergic receptors sol-ubiized from rat brain, 37
LY150720, antinociceptive effects (mon-keys), 299
LY-171555, D-2 agonist, locomotor activityand (rats), 447
Lynch, J. J., Montgomery, D. G., Ventura,A. and Lucchesi, B. R.: Antiar-rhythmic and electrophysiologic ef-fects of bepridil in chronically in-farcted conscious dogs, 72
Lysergic acid diethylamide, discriminativestimulus properties (monkeys), 244
Macdonald, R. L., see Werz, M. A., 49MacLeod, K. M., see Broadley, K. J., 222
Majewski, H., see Ensinger, H., 681
Maldonado, A. L., see Speeg, K. V., Jr., 550Mandell, A. J., see Lee, E. H. Y., 141Maniwa, T., see Morita, T., 728Marijuana, binding sites, brain (rats), 784Marks, G. S., see Bennett, B. M., 228Marrazzi, M. A., McRae, W. and Brown, J.
A.: Thioglucose interactions with a“gold thioglucose-lesioned glucostat,”804
Massotti, M., Lucantoni, D., Caporali, M.G., Mele, L. and Gatta, F.: Supraspi-nal convulsions induced by inversebenzodiazepine agonists in rabbits,274
Matthews, W. D., see Jim, K. F., 161Mayersohn, M., see Woodworth, J. R., 654
McAllister, C. B., see Wedlund, P. J., 662
McCall, R. B., see Humphrey, S. J., 288McGiff, J. C., see Quilley, J., 211McNeil, J. H., see Broadley, K. J., 222McRae, W., see Marrazzi, M. A., 804
MDL 17,043, positive inotropic effect, yen-tricular muscle (dogs), 267
Meier, W., see Londowski, J. M., 25Meijer, D. K. F., see van der Sluijs, P., 703Melatonin receptors, see ReceptorMele, L., see Massotti, M., 274Membrane, depolarization, Goniopora tox-
ins and, axons (crayfish), 307Memory, triazolam us. pentobarbital effects,
120
Mendelsohn, L. G., Johnson, B. G., Scott,
W. L. and Frederickson, R C. A.:Thiorphan and analogs: Lack of cor-relation between potency to inhibit
“enkephalinase A” in vitro and an-algesic potency in vivo, 386
Mephenytoin, pharmacokinetics, pheno-
typic differences, normal subjects,662
Metal, urinary excretion, L-(aS,5S)-a-
amino-3-chloro-4,5-dihydro-5-isoxa-
zoleacetic acid effects (mice), 156Metaphit, phencyclidine receptor acylator,
effects on catalepsy (pigeons), 648Met-enkephalin, see Methionine enkepha-
haMethadone, chronic administration, neu-
roendocrine function and (rats), 204
Methanesulfonyl fluoride, edrophonium,physostigmine and, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539
Methionine enkephalininfusion into substantia nigra, maximal
electroshock seizure protection(rats), 45
intravenous, ventilatory response (dogs),677
motility stimulated by, cycbooxygenase in-hibitor effects, colon (rats), 742
renal nerve activity, suppression by (rab-bits), 534
Methoxamine, pressor response (dogs), 7280-Methylation, isoproterenol, aorta (rab-
bits), 184
Methylmercury, urinary excretion, L-(aS,
5S)-a-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid effects (mice),156
Methylphenidate, tetrahydrobiopterin and
biogenic amine concentrations,changes induced by, brain (rats), 141
Metoproloh, aspirin antihypertensive effect,
inhibition by (rats), 166
Meyer, W., see Bruckner, R., 766Mezzetti, M., see Sautebin, L., 217Microparticles, polyacryl starch, trapped
protein, immune response (mice), 255Microspheres, biodegradable, trapped pro-
tein, immune response (mice), 255Migrating myoelectric complex, biphasic re-
sponse to morphine, intestine (dogs),814
Miller, D. B., see O’Callaghan, J. P., 522Minneman, K. P., see Nasseri, A., 350Mitchell, M. C., see Speeg, K. V., Jr., 550Miura, A., see Muramatsu, I., 307Miyasato, K., see Henningfield, J. E., 1Moalli, R., Howell, R. E. and Gilhis, C. N.:
Kinetics of captopril- and enalapril-induced inhibition of pulmonary an-giotensin converting enzyme in vivo,372
Mohinoff, P. B., see Hedberg, A, 561Mong, S., Wu, H.-L., Scott, M. 0., Lewis,
M. A., Clark, M. A., Weichman, B.M., Kinzig, C. M.,Gleason, J. G. andCrooke, S. T.: Molecular heteroge-neity of leukotriene receptors: Cor-relation of smooth muscle contrac-tion and radioligand binding inguinea-pig lung, 316
Monoamine, regulation, drug effects, brain(rats), 141
Monomorphine, N-acetylation, genetic dif-ferences, liver (hamster), 358
Montgomery, D. G., see Lynch, J. J., 72
Morgan, W. W., see Lane, S. J., 569Morita, T., Maniwa, T., Satoh, K. and
Taira, N.: Undifferentiated effects ofcalcium antagonists on pressor re-sponses to selective a�pha-1 and a!-
pha-2 adrenoceptor agonists in anes-thetized, spinal dogs, 728
Morita, T., see Endoh, M., 267Morphine
biphasic response to, intestinal migratingmyoelectric complex (dogs), 814
electric shock titration and (monkeys),299
enantiomers, natural and unnatural(rats), 761
infusion into substantia nigra, maximalelectroshock seizure protection
(rats), 45opiate agonist-antagonist interactions,
drug discrimination (pigeons), 81pupillary effects (cats), 603
tolerance, escape titration and (monkeys),94
Mueller, R. A., see Breese, G. R., 447Mueller, R. A., see Duncan, G. E., 402
Mulder, G. J., see Dawson, J. R, 691Mulder, K. M. and Kostyniak, P. J.: Effect
of L-(aS,5S)-a-amino-3-chboro-4,5-dihydro-5-isoxazoleacetic acid on un-nary excretion of methylmercury inthe mouse, 156
Munamatsu, I., Fujiwara, M., Miura, A. and
Narahashi, T.: Effects of Gonioporatoxin on crayfish giant axons, 307
Murray, L., see Allen, T. M., 250Musacchio, J. M., see Bahouth, S. W., 326
Muscle, skeletaldigitalis receptors, [3H)ouabain distribu-
tion (guinea pigs), 720surface membrane bound calcium, dis-
placement (frogs), 233Muscle, smooth
contraction5-hydnoxytryptamine receptor-medi-
ated, aorta (rats), 443leukotriene receptors and, lung (guinea
pigs), 316dysfunction, lead-induced, crop (pigeons),
607postjunctional supersensitivity, reser-
pine-induced, alpha adnenergic recep-tors and (rats), 350
relaxation, lead-induced, crop (pigeons),616
vascularalpha-i receptor-mediated contraction,
desensitization (rabbits), 147calcium channels, bepnidil hydnochlo-
ride effects, aorta (rabbits), 63relaxation, W-7 anticalmodulin prop-
erties (rats, rabbits), 476ventricular, electrophysiobogy, dimethyl-
propranolol effects (guinea pigs), 507
Mydniasis, morphine-induced, pupillarylight reflex and fluctuation inhibition(cats), 603
Myocardium
Ca� and K� channels, blocking (frogs),134
ischemia and infarction, bepridil effects
(dogs), 72
844 Index Vol. 234
solutes, transcapillary transport (rabbits),19
Myosin, phosphorylation, perhexilene andcinnarizine effects, vascular and car-diac contractile protein (cows, dogs),629
Nakaki, T., Roth, B. L., Chuang, D.-M. andCosta, E.: Phasic and tonic compo-nent.s in 5-HT2 receptor-mediated rat
aorta contraction: Participation ofCa� channels and phospholipase C,442
Nakane, M., see Ogletree, M. L., 435Nakatsu, K., see Bennett, B. M., 228
Naloxonebiphasic response to, intestinal migrating
myoelectric complex (dogs), 814methionine enkephalin and, renal nerve
activity (rabbits), 534opiate infusion into substantia nigra and,
maximal electroshock seizure protec-tion (rats), 45
Naloxone methobromide, methionine en-kephalin and, renal nerve activity(rabbits), 534
Naltrexone, opiate agonist-antagonist inter-actions, drug discrimination (pi-geons), 81
l-Nantradol, tolerance, escape titration and
(monkeys), 94Napier, T. C., see Breese, G. R., 447Narahashi, T., see Muramatsu, I., 307Nasseri, A., Barakeh, J. F., Abel, P. W. and
Minneman, K. P.: Reserpine-inducedpostjunctional supersensitivity in rat
vas deferens and caudal artery with-out changes in alpha adnenergic re-ceptors, 350
Neostigmine, nonadnenergic inhibitory sys-tam, lung (cats), 590
Nephrectomy, gentamicin excretion and(dogs), 90
Nephrotoxicity
aminoglycoside excretion, nephrectomyand (dogs), 90
antibiotic, augmentation by endotoxemia(rabbits), 425
1-(2-chloroethyl)-3-(trans-4-methylcy-cbohexyl)-1-nitrosourea, buthioninesulfoximime effects on (rats), 498
Nervous systemcentral
bihirubin neurotoxicity and cerebellarproteins (rats), 522
SKF 82526 and, cardiovascular dopa-mine receptors (dogs), 337
sympathetichyperinnervation, spontaneous hyper-
tension and, caudal artery (rats), 792
inhibitory response, y-aminobutyricacid mediation (cats), 288
renal nerve activity, suppression by me-thionine enkephahin (rabbits), 534
Neural adaptation, antidepressants andforced swim, beta adnenergic receptordown-regulation (rats), 402
Neuromuscular junction, cholinergic, teta-
nus toxin binding (mice), 100Neuron, giant, slow outward current, bar-
biturate-induced alterations (mol-
lusks), 821Neuropeptide Y, noradnenaline-eyoked va-
soconstriction and (rabbits), 735
Neunotoxicity, bihirubin, cerebellar proteins
and (rats), 522Nicotine
behavioral effects (dogs, monkeys), 106
intravenous and inhaled, abuse liabilityand pharmacodynamic characteris-tics, 1
renal clearance, nicotine intake and, 153
Nielsen, E. B.: Discriminative stimulusproperties of lysergic acid diethyl-amide in the monkey, 244
Nifedipine
aorta contraction and (rats), 443beta receptors and, heart, 561calcium channels, effects on, vascular
smooth muscle of aorta (rabbits), 63vasodepressor effects (dogs), 728
Nimodipine, a�pha adnenergic activation, in-hibition by, saphenous vein (dogs),598
Nitrate, organic, biotransformation byerythrocytes, 228
2-Nitro-4-carboxyphenyl-N,N-diphenylcar-
bamate, aorta contraction and (rats),443
Nitroglycerin, capillary permeability and,myocardium (rabbits), 19
Nobis, T.-M., see Bruckner, R., 766Nomifensine, forced swim and, beta adne-
nergic receptor down-regulation
(rats), 402Noradrenaline, see Norepinephnine
Norcocaine, behavioral effects (dogs, mon-keys), 106
Norepinephrinealpha adnenoceptors and, intermediate
auricular artery (dogs), 698cyclic nucleotide generating system, imi-
pramine and adrenocorticotropin ef-fects on, brain (rats), 409
hyperinnervation, spontaneous hyperten-sion and, caudal artery (rats), 792
nimodipine and, saphenous vein (dogs),598
release, blood pressure, dopamine andbromocriptine effects (rabbits), 681
reserpine-induced postjunctional super-sensitivity and, van deferens and cau-dal artery (rats), 350
vasoconstriction evoked by, potentiationby neuropeptide Y (rabbits), 735
N#{248}rgaard, A., see Kjeldsen, K., 720Nornicotine, behavioral effects (dogs, mon-
keys), 106Northrup, N., see Tuttle, R. S., 166
Nucheotide, guanine, [3H]substance P bind-ing, submaxillary gland (rats), 326
Nyc, J. S., Seltzman, H. H., Pitt, C. G. andSnyder, S. H.: High-affinity canna-binoid binding sites in brain mem-branes labeled with [3H]-5’-trimeth-ylammoniuin �8-tetrahydnocannabi-nol, 784
O’Brien, M. S., Salamone, L. F. and Gibson,T. P.: Effect of spironolactone on therenal clearance of digoxin in dogs,190
O’Callaghan, J. P. and Miller, D. B.: Cere-bellar hypoplasia in the Gunn rat isassociated with quantitative changesin neurotypic and ghiotypic proteins,522
Oculomucocutaneous syndrome, practobol-induced (hamsters), 476
O’Donnell, J. M. and Fraser, A.: Effects ofclenbuterol and antidepressant drugs
on beta adrenergic receptor/N-pro-tein coupling in the cerebral cortexof the rat, 30
Ogletree, M. L., Harris, D. N., Greenberg,R, Haslanger, M. F. and Nakane, M.:Pharmacological actions of SQ29,548, a novel selective thrombox-ane antagonist, 435
#{248}ie,S. and Fiori, F.: Effects of albumin andalpha-i acid glycoprotein on ehimi-nation of prazosin and antipynine inthe isolated perfused rat liver, 636
Opiate
biphasic response to, intestinal migratingmyoelectric complex (dogs), 814
infusion into substantia nigra, maximal
electroshock seizure protection
(rats), 45methadone, chronic administration, neu-
roendocrine function and (rats), 204
Opioidkappa, diuresis and vasopressin suppres-
sion (rats), 463lidocaine disposition and toxicity, effects
on (mice), 391pupillary light reflex, effects on (cats), 603
surface membrane bound calcium, dis-placement, skeletal muscle (frogs),233
Opioid peptidecalcium-dependent action potential du-
ration, dorsal root ganglion neuron(mice), 49
methionine enkephalin, renal nerve activ-ity suppression (rabbits), 534
Orton, T. C., see Rosenbaum, S. E., 485Ouabain, 3H-labehed, binding, digitalis re-
ceptors and, skeletal muscle (guineapigs), 720
Owens, S. M., see Woodworth, J. R., 654Oxidative metabolism, hepatic, influence on
6-thiopunine metabolites (mice), 670
Pang, K. S., see Dawson, J. R., 691Parenchyma
contractility, mediators of anaphylaxisand (dogs), 491
lung, leukotriene release patterns, 217
Pargyline, forced swim and, beta adrenergic
receptor down-regulation (rats), 402Patel, S., see Tuttle, R. S., 166
Paul, I. A., see Duncan, G. E., 402Paul, R J., see Rubanyi, G. M., 555
Pentobarbital, triazolam vs., 120Pentylenetetrazol, convulsions and, serum,
brain and cerebrospinal fluid (rats),624
Peptideopioid, see Opioid peptideperoral, diabetes insipidus treatment, 754
Peptidoleukotriene, smooth muscle contrac-tion and, lung (guinea pigs), 316
Perhexilene, vascular and cardiac contract-ile protein function, effects on (cows,dogs), 629
Peterson, D. F., see Rhee, H. M., 534Peterson, M. E., see Aucoin, D. P., 13pH
blood-brain gradient, influence on pheno-barbital uptake, status epilepticus,830
electrolyte reabsorption and, acetazol-
1985 Index 845
amide effects, kidney tubules (dogs),747
urinary, nicotine intake and clearance,153
Phagocytic index, enzyme-albumin conju-gates, chronic administration effects
(mice), 250Pharmacokinetics, probenecid, glucuroni-
dation inhibition, 345Phencycidine
disposition kinetics (dogs), 654receptor acylator, catalepsy, effects on
(pigeons), 648tolerance and physical dependence (rats),
415
Phenidone, beta adnenergic responsiveness,arachidonic acid metabolite effectson, coronary artery (cows), 555
Phenobarbitalmorphine and, comparative metabolism
(rats), 761uptake, blood-brain pH gradient influence
on, status epilepticus (rats), 830
uremia and (rats), 180Phenotype, oxidative, mephenytoin, normal
subjects, 662
Phenoxybenzamine, nimodipine and, saphe-nous vein (dogs), 598
Phenylephrine, a�pha adrenoceptors and,intermediate auricular artery (dogs),698
Phenylethylhydantoin, pharmacokinetics,phenotypic differences, normal sub-jects, 662
Phosphoinositide, hydrolysis, serotonin-stimulated (rats), 195
Phosphoinositol, turnover, a!pha-1 receptor
stimulation of, desensitization (rab-bits), 147
Phosphohipase C, calcium ion channels and,aorta contraction mechanism (rats),
443
Phosphohipids, serotonin effects (rats), 195
Phosphorylationmyosin, perhexilene and cinnarizine ef-
fects, vascular and cardiac contractileprotein (cows, dogs), 629
protein, vasopressin-mediated, urinary
bladder (toads), 515Physostigmine, edrophonium and methane-
sulfonyl fluoride, end-plate acetyl-choline receptor-channel complex,interactions (snakes), 539
Picenadol, antinociceptive effects (mon-keys), 299
Pickworth, W. B. and Sharpe, L. G.: Mor-phine-induced mydniasis and inhibi-tion ofpupillary light reflex and fluc-tuations in the cat, 603
Picrotoxin, vasopressin release stimulatedby (rats), 378
Pinto, P. B., see Silver, P. J., 629Pirenzepine, radiolabeled, binding to mus-
caninic chohinergic receptors, brain(rats), 37
Pitt, C. G., see Nye, J. S., 37Platelet, aggregation inhibition, SQ 29,548,
435Polyacryl starch, microparticles, protein
trapped in, immune response (mice),255
Pond, S. M., see Waschek, J. A., 431
Potassium, currents, blocking, calciumchannel antagonists (frogs), 134
Poznansky, M. J., see Allen, T. M., 250
Practolol, metabohites, disposition (ham-stern), 485
Prada, J. A., see Risner, M. E., 113
Prazosinalpha adrenoceptors and, intermediate
auricular artery (dogs), 698elimination, albumin and a4,ha-1 acid
glycoprotein effects, liver (rats), 636nimodipine and, saphenous vein (dogs),
598urapidil and, reflex tachycandia suppres-
sion (dogs), 456Pregnancy, hypoxia and, antipynine metab-
olism, liver (rats), 584Probenecid, glucuronidation inhibition by,
345
Propranololbeta receptors and, heart, 561clearance, reduced, carbon tetrachloride
and, liver (rats), 470Propylthiouracil, toxicity (cats), 13Prostacychin
beta adrenergic responsiveness, effects on,
coronary artery (cows), 555vascular, diabetes melhitus (rats), 211
Prostaglandin
colonic motility and (rats), 742SQ 29,548 effects (humans, guinea pigs,
rats), 435urinary excretion, diabetes melhitus and
(rats), 211Prostaglandin E�
beta adrenergic responsiveness, effects on,coronary artery (cows), 555
prostaglandin E� and, renal, metoprololand aspirin antihypertensive effects(rats), 166
renin release and, arachidonic acid infu-sion (dogs), 261
Prostaglandin E�, prostaglandin E� and,renal, metoprolol and aspirin anti-hypertensive effects (rats), 166
Prostanoids, prostaglandin D2 and Ff4,, air-way reactivity to (dogs), 491
Proteinalpha-i acid and asialo c4pha-1 acid gly-
coprotein, cation binding, 703alpha-i acid glycoprotein, prazosin and
antipynine elimination, liver (rats),
636contractile, vascular and cardiac, calcium
antagonist effects on (cows, dogs),629
lead-binding, renal, #{246}-aminolevulinic aciddehydratase inhibition reversal(rats), 365
myelin basic, bihirubin neurotoxicity and(rats), 522
neurotypic and gliotypic, cerebehlar hy-poplasia and (rats), 522
phosphorylation, vasopressin-mediated,urinary bladder (toads), 515
Psychoactive drugs, marijuana, bindingsites, brain (rats), 784
Psychomotor performance, triazolam vs.pentobarbital effects, 120
Pung, 0., see Tucker, A. N., 57
Pupil, light reflex and fluctuation, inhibi-tion, morphine-induced mydniasisand (cats), 603
Purkinje cells, biirubin neurotoxicity, cer-ebellum (rats), 522
Purkinje fibers, caffeine-induced calciumoverload, reversal (dogs), 172
Quilley, J. and McGiff, J. C.: Arachidonicacid metabolism and urinary excre-tion ofprostaglandins and thrombox-ane in rats with experimental diabe-tes melhitus, 211
Quimby, F. W., see Aucoin, D. P., 13
Radioligandbinding
cannabinoid, brain (rats), 784smooth muscle contraction and, leuko-
triene receptors, lung (guinea pigs),
316Rafferty, M. F., see Koek, W., 648Ramzan, I. M. and Levy, G.: Kinetics of
drug action in disease states. XIV.Effect of infusion rate on pentylene-tetrazol concentrations in serum,brain and cerebrospinal fluid of ratsat onset of convulsions, 624
Rane, A., Gawronska-Szklarz, B. and Svens-son, J.-O.: Natural (-)- and unnatu-ral (+)-enantiomers of morphine:Comparative metabolism and effectof morphine and phenobarbital treat-
ment, 761Ratz, P. H., see Flaim, S. F., 63Ratz, P. H. and Flaim, S. F.: Acetylchohine-
and 5-hydroxytryptamine-stimulatedcontraction and calcium uptake inbovine coronary arteries: Evidencefor two populations of receptor-op-erated calcium channels, 641
Rauwolscine, nimodipine and, saphenousvein (dogs), 598
Receptor
alpha adrenergic, reserpine and, vas def-erens and caudal artery (rats), 350
alpha-i adnenergic, smooth muscle con-
traction, desensitization (rabbits),147
a4pha and beta adrenergic, cyclic nucleo-tide generating system, imipramineand adnenocorticotropin effects on,brain (rats), 409
beta adrenergiccoupling with N-protein, clenbuterol
and antidepressant drug effects(rats), 30
down-regulation, antidepressants andforced swim (rats), 402
beta-i and beta-2 adrenergic, coexistence,heart, 561
calcium channel operation, coronary ar-
tery contraction (cows), 641
cannabinoid binding sites, brain (rats),784
digitalis, [3H]ouabain binding and, skele-tel muscle (guinea pigs), 720
dopaminecardiovascular, SKF 82526 and (dogs),
337functional supersensitivity (rats), 447pre- and postjunctional, blood pressure
effects (rabbits), 681
histamine, smooth muscle contractionmediated by, desensitization (rab-bits), 147
leukotriene, molecular heterogeneity,
lung (guinea pigs), 316melatonin, retinal (rabbits, chickens), 395muscaninic cholinergic, [3H]pirenzepine
binding to, brain (rats), 37opiate, trimebutine effects on colon elec-
tromyogram (cats, rabbits), 708
846 Index Vol. 234
opioid, kappa, calcium conductance(mice), 49
phencyclidine, acylator, effects on cats-
lepsy (pigeons), 648reserve, nimodipine and, saphenous vein
(dogs), 598serotonin
aorta contraction, phasic and toniccomponents (rats), 443
5-HT1 and 5-HT2, behavior and (mon-keys), 106
substance P, binding, submaxillary gland(rats), 326
Receptor acylator, phencychidine, catalepsyand (pigeons), 648
Receptor-channel complex, end-plate ace-tylchohine, edrophonium, physostig-mine and methanesulfonyl fluorideinteractions with (snakes), 539
Red blood cell, see ErythrocyteReidenberg, M. M., see Aucoin, D. P., 13Renal artery, constriction, prostaghandin E�
and ream release, arachidonic acidinfusion (dogs), 261
Renal nerve, activity suppression, methio-nine enkephalin (rabbits), 534
Renin, release, prostaglandin E� and, arach-idonic acid infusion (dogs), 261
Reserpine, postjunctional supersensitivityinduced by, vas deferens and caudalartery (rats), 350
Responsiveness, beta adnenergic, arachi-
donic acid metabohite effects on, cor-onary artery (cows), 555
Reticuloendothelial system, enzyme-albu-mm conjugates, chronic administra-tion effects (mice), 250
Retina, melatonin receptor (rabbits, chick-ens), 395
Reyntjens, A. J., see Schuurkes, J. A. J., 775
Rhee, H. M., Eulie, P. J. and Peterson, D.F.: Suppression of renal nerve activ-ity by methionine enkephahin inanesthetized rabbits, 534
Rice, J. C., see Evanich, M. J., 677Rice, K. C., see Koek, W., 648Rice, P. J., see Goto, K., 280Righting reflex, loss, phenobarbital and ure-
mia (rats), 180
Rimele, T. J., see Cooke, J. P., 598Risner, M. E., Goldberg, S. R., Prada, J. A.
and Cone, E. J.: Effects of nicotine,cocaine and some of their metaboliteson schedule-controlled responding bybeagle dogs and squirrel monkeys,113
Riviere, J. E., Bowman, K. F. and Rogers,R. A.: Decreased fractional renal ex-cretion of gentamicin in subtotal
nephrectomized dogs, 90Roache, J. D. and Griffiths, R. R.: Compar-
ison of triazolam and pentobarbital:Performance impairment, subjectiveeffects and abuse liability, 120
Rodgers, R. L., see Broadley, K. J., 222
Rogers, R A., see Riviere, J. E., 90
Rosenbaum, S. E., Lindup, W. E. and Orton,T. C.: Practolol and its metabohites:
Tissue localization and retention inthe hamster, 485
Rotarod, phencycidine tolerance and (rats),415
Roth, B. L., see Nakaki, T., 442
Rubanyi, G. M. and Paul, R. J.: Modulationof beta adnenergic responsiveness by
arachidonic acid metabolites in iso-lated bovine coronary arteries, 555
Rubin, G. M., see Waschek, J. A., 431Rudolph, S. A., see Konieczkowski, M., 515
Sabouni, M. H., see Lokhandwala, M. F.,337
Salamone, L. F., see O’Brien, M. S., 190Salicylamide, dose-dependent sulfoconjuga-
tion (dogs), 431
Sander, G. E., see Evanich, M. J., 677Sanders-Bush, E., see Conn, P. J., 195Saphenous vein
a4pha adrenergic receptors, nimodipine ef-fects (dogs), 598
contractions, a�pha-2 adnenoceptors and,calcium role (dogs), 161
Sarna, S. K. and Lang, I. M.: Dose- andtime-dependent biphasic response to
morphine on intestinal migratingmyoelectric complex, 814
Satoh, H. and Vassalle, M.: Reversal of cal-feine-induced calcium overload incardiac Purkinje fibers, 172
Satoh, K., see Morita, T., 728Satoh, M., see Iwamoto, K., 470
Sautebin, L., Vigan#{244}, T., Grassi, E., Crivel-
lan, M. T., Galhi, G., Berti, F., Mez-zetti, M. and Folco, G.: Release ofheukotrienes, induced by the Ca�ionophore A23187, from human lungpanenchyma in vitro, 217
SCH-23390, D-1 antagonist, locomotor ac-tivity and (rats), 447
Scheurer, U., Drack, E. and Halter, F.: Cy-cbooxygenase inhibitors affect Met-
enkephalin- and acetylchohine-stim-ulated motility of the isolated rat co-ba, 742
Schmitz, W., see Bruckner, R., 766Scholz, H., see Bruckner, R., 766Schuller, H. M., see Kramer, R. A., 498Schuurkes, J. A. J., Van Nueten, J. M., Van
Daele, P. G. H., Reyntjens, A. J. andJanssen, P. A. J.: Motor-stimulatingproperties of cisapride on isolatedgastrointestinal preparations of the
guinea pig, 775Scott, M. 0., see Mong, S., 316Scott, W. L., see Mendelsohn, L. G., 386Seizure, maximal electroshock, protection,
opiate infusion into substantia nigra
(rats), 45Sejersted, 0. M., see Vikse, A., 261Seltzman, H. H, see Nye, J. S., 37Serotonin
acetylchohine and, calcium channels acti-vated by, coronary artery (cows), 641
agonists and antagonists, lysergic acid di-ethylamide discriminative stimulusproperties (monkeys), 244
antagonists, behavioral effects (mon-keys), 106
binding sites, phosphoinositide hydrolysisand (rats), 195
receptors, see ReceptorSerum, pentylenetetrazol concentrations,
infusion rate effects on, convulsions(rats), 624
Shader, R. I., see Abernethy, D. R., 345Sharpe, L. G., see Pickworth, W. B., 603
Shebuski, R. J. and Zimmerman, B. G.: Sup-pression of reflex tachycardia by cen-tm! administration ofthe aLpha-i ad-
renoceptor antagonists unapidil and
prazosin in anesthetized dogs, 456Shetty, S. S. and Frank, G. B.: Displacement
of the surface membrane bound cal-cium of the skeletal muscle fibers ofthe frog Effects of lanthanum andopioids, 233
Shibata, S., see Kodama, I., 507Silver, P. J., Dachiw, J., Ambrose, J. M. and
Pinto, P. B.: Effects of the calciumantagonists perhexiline and cinnari-zine on vascular and cardiac con-tractile protein function, 629
Simon, R. P., Benowitz, N., Hedlund, R.and Copeland, J.: Influence of theblood-brain pH gradient on brain
phenobarbital uptake during statusepilepticus, 830
Simpson, L. L.: Pharmacological experi-meats on the binding and internali-zation of the 50,000 dalton carboxy-
terminus of tetanus toxin at the cho-linergic neuromuscular junction, 100
Sj#{246}holm, I., see Artursson, P., 255SKF-38393, D-i agonist, locomotor activity
and (rats), 447SKF 82526, cardiovascular dopainine recep-
tors and (dogs), 337Smith, A. C., see Kramer, R. A., 498
Smith, J. B.: Effects of single and repeateddaily injections of morphine, clom-dine and 1-nantradol on respondingof squirrel monkeys under escape ti-tration, 94
Snyder, S. H., see Nye, J. S., 37Sodium, conductance, dimethylpropranolol
effects, ventricular muscles (guineapigs), 507
Sodium channelfast, dimethylpropranohol effects, ventric-
ular muscles (guinea pigs), 507Gornopora toxin effects, axons (crayfish),
307Sonenberg, M., see Haspel, H. C., 575
Spain, J. W. and Klingman, G. I.: Continu-ous intravenous infusion of phency-cidine in unrestrained rats results inthe rapid induction of tolerance andphysical dependence, 415
Spannnhake, E. W., Kadowitz, P. J. andKleeberger, S. R.: Influence of media-tors of anaphylaxis on collateral yen-tilation and the lung periphery of thedog, 491
Speeg, K. V., Jr., Mitchell, M. C. and Mal-donado, A. L.: Additive protection ofcimetidine and N-acetylcysteinetreatment against acetaminophen-induced hepatic necrosis in the rat,550
Spinal cord, transection, vasopressin releasestimulation, �y-aminobutynic acid an-tagonista (rats), 378
Spironolactone, digoxin, renal clearance(dogs), 190
SQ 29,548, thromboxane antagonist (hu-mans, guinea pigs, rats), 435
St-587, nimodipine and, saphenous vein
(dogs), 598Starke, K., see Ensinger, H., 681Status epilepticus, phenobanbital uptake
during, blood-brain pH gradient in-fluence on (rats), 830
Stiliwell, R. N., see Dawson, J. R., 691Stitzel, R. E., see Cassis, L. A., 792
1985 Index 847
Stitzel, R. E., see Head, R. J., 184
Stomach, [3H�acetylcholine release, dope-mine regulation or (guinea pigs), 713
Strada, S. J., see Duman, R. S., 409
Street value, estimated, triazolam vs. pen-tobarbital, 120
Structure-activity relationships, melatoninderivatives (rabbits, chickens), 395
Stumpf, W. E., see Duncan, G. E., 402Submaxillary gland, [3Hjsubstance P, spa-
cific binding (rats), 326Substance P, [3H]-labeled, specific binding,
submaxillary gland (rats), 326Substantia nigra, opiate infusion into, max-
imal electroshock seizure protection(rats), 45
Sucrose, permeability-surface area prod-ucts, transcapillary transport, myo-cardium (rabbits), 19
Sulfate, depletion or administration, sulfo-conjugation (dogs), 431
Sulfoconjugation, dose-dependent, salicyl-amide (dogs), 431
Sulmazole, positive inotropic effect, ventric-ular muscle (dogs), 267
Sulpiride, [3Hjacetylcholine release, dopa-mine regulation of, stomach (guineapigs), 713
Supersensitivity, reserpine-induced. a�phaadrenergic receptors and, vas defer-ens and caudal artery (rats), 350
Svensson, J.-O., see Rane, A., 761Swigart, S. C., see Flaim, S. F., 63Sympathectomy, cardiac, sensitivity to ag-
onists and (rats, guinea pigs), 280Sympathetic nervous system, see Nervous
systemSynapsin I, phosphoprotein, bihirubin neu-
rotoxicity and, cerebellum (rats), 522Szarek, J. L., see Altiere, R. J., 590
Tachycardia
reflex, aZpha-1 adrenoceptor antagonist
effects (dogs), 456ventricular, bepridil effects (dogs), 72
Tachykinin receptors, see ReceptorTaira, N., see Endoh, M., 267Taira, N., see Morita, T., 728Tanaka, C., see Kusunoki, M., 713Taniyama, K., see Kusunoki, M., 713Taylor, D. A., see Goto, K., 280Tetanus toxin, binding, cholinergic neuro-
muscular junction (mice), 100
12-O-Tetradecanoylphorbol-13-acetate,aorta contraction and (rats), 443
Tetrahydrobiopterin, drug effects on, brain(rats), 141
Tetrahydrocannabinol, binding sites, brain(rats), 784
Tetrodotoxincaffeine-induced calcium overload and,
Purkinje fibers (dogs), 172Goniopora toxins and, axons (crayfish),
307Thioglucose, “gold thioglucose-lesioned glu-
costat” and, interactions (mice), 8046-Thiopurine, metabolites, immunosuppres-
sive, hepatic oxidative metabolisminfluence on (mice), 670
Thiorphan, analgesia and (rats), 386
Thromboxaneantagonist, SQ 29,548 (humans, guinea
pigs, rats), 435urinary excretion, diabetes melhitus and
(rats), 211
Thromboxane A2antagonist, SQ 29,548 (humans, guinea
pigs, rats), 435formation, lung, 217
Thromboxane synthetase, SQ 29,548 ef-fects, platelets (humans, guinea pigs,rats), 435
Tozer, T. N., see Waschek, J. A., 431Trachea
contraction inhibition, SQ 29,548 effects(guinea pigs), 435
neurally mediated nonadrenergic relaxa-
tion (cats), 590
Transmembrane potential, dimethylpro-pranolol effects, ventricular muscles(guinea pigs), 507
Triazolam, pentobarbital vs., 120Trimebutine, colon electromyogram, effects
on (cats, rabbits), 708Troleandomycin, dihydroergotamine up-
take, effects on, liver (rats), 239Tsujimoto, G., see Lurie, K. G., 147Tucker, A. N., Hong, L., Boorman, G. A.,
Pung, 0. and Luster, M. I.: Alterationof bone marrow cell cycle kinetics bydiphenylhydantoin: Relationship to
folate utilization and immune func-tion, 57
Tune, B. M. and Hsu, C.-Y.: Augmentationof antibiotic nephrotoxicity by endo-toxemia in the rabbit, 425
Tuttle, R. S., Banziger, V., Patel, S. andNorthrup, N.: Inhibition by metopro-
lol of the antihypertensive effect ofaspirin in young rats, 166
Tyramine, nimodipine and, saphenous vein(dogs), 598
UM-272, see DimethylpropranololUrapidil, prazosin and, reflex tachycardia
suppression (dogs), 456Uremia, dialyzable components, phenobar-
bital concentrations and, loss ofrighting reflex (rats), 180
Ureter, occlusion, prostaglandin E� andream release, anachidonic acid infu-sion (dogs), 261
Urination, vasopressin suppression, diuresisand, kappa opioids (rats), 463
Urinemethylmercury excretion, L-(aS,5S)-a-
amino-3-chloro-4,5-dihydro-5-isoxa-zoleacetic acid effects (mice), 156
pH, nicotine intake and clearance, 153prostaglandin and thromboxane excre-
tion, diabetes mellitus (rats), 211
Van Daele, P. G. H., see Schuurkes, J. A. J.,775
van der Sluijs, P. and Meijer, D. K. F.:Binding of drugs with a quaternaryammonium group to a�pha-i acid gly-coprotein and asialo a!pha-1 acid gly-coprotein, 703
Vanhoutte, P. M., see Cooke, J. P., 598Van Nueten, J. M., see Schuurkes, J. A. J.,
775Vardax, vascular and cardiac contractile
protein function, effects on (cows,dogs), 629
Vas deferens, postjunctional supersensitiv-ity, reserpine-induced, a�pha adrener-gic receptors and (rats), 350
Vasoconstriction, noradrenaline-evoked,
potentiation by neuropeptide Y (rab-bits), 735
Vasodilation
autoregulatory, prostaglandin E� andrenin release, arachidonic acid infu-sion (dogs), 261
coronary, transcapillany solute transport,myocardium (rabbits), 19
Vasopressin
protein phosphorylation mediated by, un-nary bladder (toads), 515
release, stimulation by y-aminobutynicacid antagonists (rats), 378
suppression, diuresis and, kappa opioids(rats), 463
Vassalle, M., see Satoh, H., 172Velocity, maximal initial, dimethylpropran-
olol effects, ventricular muscles(guinea pigs), 507
Ventilationcollateral, anaphylaxis mediators and,
lung periphery (dogs), 491methionine enkephalin effects (dogs), 677
Ventura, A., see Lynch, J. J., 72Verapamil
calcium channels, effects on, vascularsmooth muscle of aorta (rabbits), 63
diltiazem and, coronary artery contrac-tion (cows), 641
Vigan#{244},T., see Sautebin, L., 217
Vikse, A., Sejersted, 0. M. and Kiil, F.:Autoregulatory vasodilation en-hances renal prostaglandin E� andassociated ream release during ar-achidonic acid infusion in dogs, 261
Vilhardt, see Hammer, M., 754Vitamin D, 3�-D-glucopynanosides, biologic
activity (rats), 25Voltage clamp
cardiac, myocardial Ca� and K� channelblocking (frogs), 134
Goniopora toxins and, axons (crayfish),307
slow outward current, barbiturate-in-duced alterations (mollusks), 821
Vore, M., see Brouwer, K. L. R., 584
W-7anticalmodulin properties, artery (rats,
rabbits), 476vascular and cardiac contractile protein
function, effects on (cows, dogs), 629Wahlestedt, C., Edvinsson, L., Ekblad, E.
and H#{226}kanson,R: Neuropeptide Ypotentiates noradrenaline-evokedvasoconstriction: Mode of action, 735
Waschek, J. A., Fielding, R. M., Pond, S.M., Rubin, G. M., Effeney, D. J. andTozer, T. N.: Dose-dependent sulfo-conjugation of sahicylamide in dogs:Effect of sulfate depletion or admin-istration, 431
Watanabe, J., see Iwamoto, K., 470Watkins, H. 0., see Lokhandwala, M. F.,
337Weber, W. see Hein, D. W., 358Wedlund, P. J., Aslanian, W. A., Jacqz, E.,
McAllister, C. B., Branch, R. A. andWilkinson, G. R.: Phenotypic differ-ences in mephenytoin pharmacoki-netics in normal subjects, 662
Weichman, B. M., see Mong, S., 316Weitering, J. G., see Dawson, J. R., 691Werz, M. A. and Macdonald, R. L.: Dynor-
phin and neoendorphin peptides de-
848 Index
crease dorsal root ganglion neuroncalcium-dependent action potentialduration, 49
Weselcouch, E. 0., Lucchesi, K. J., Luneau,C. J. and Gossehin, R. E.: Transcap-illary transport ofsolutes in the myo-cardium: Effects of nitroglycerin, iso-proterenol and histamine on perme-ability-surface area products of insu-ha and sucrose, 19
Wible, J. H., Jr., Zerbe, R. L. and DiMicco,J. A.: Stimulation of vasopressinrelease by ‘y-aminobutynic acid an-tagonists in spinal cord transectedrats, 378
Wilkinson, G. R., see Wedlund, P. J., 662
Wilson, W. A., see Huguenard, J. R., 821Withdrawal abstinence syndrome, phency-
cidine, rotarod performance and(rats), 415
Wolfe, B. B., see Luthin, G. R., 37Woods, J. H., see France, C. P., 81Woods, J. H., see Koek, W., 648Woodworth, J. R., Owens, S. M. and May-
ersohn, M.: Phencyclidine (PCP) dis-position kinetics in dogs as a functionof dose and route of administration,654
Wu, H.-L., see Mong, S., 316
Vol. 234
Xylazine
a’pha adrenoceptors and, intermediateaunicular artery (dogs), 698
pressor response (dogs), 728
Yamada, K., see Kodama, I., 507Yanagisawa, T., see Endoh, M., 267Yohimbine, alpha adrenoceptors and, inter-
mediate auricular artery (dogs), 698
Zerbe, R.L., see Leander, J. D., 463Zerbe, R. L., see Wible, J. H., Jr., 378Zimmerman, B. G., see Shebuski, R. J., 456