655

INDEX

Volume 216, January-March 1981

Abukhres, M. M., see Voilmer, R.

It, 580Acetaldehyde, effect on placental

valine uptake (rats), 465Acetylcholine, effect of reserpine

pretreatment on femoral ar-terial responses to (dogs), 447

levo-a-Acetylmethadol, and me-tabolites, effects on schedule-

controlled behavior (pi-geons), 299

Acivicin, sex- and age-relatedtoxicity and disposition of

(mice), 433

Acyclovir, pharmacokinetics and

bioavailability (dogs), 281Adenine nucleotides, involvement

in sympathetic nerves of bas-ilar artery (dogs), 401

Adenosine

effect of reserpine pretreatment

on femoral arterial responsesto (dogs), 447

effects on mechanical perform-ance and electrical activity in

heart (dogs), 254

S-adenosylmethionine adminis-tration, decreased cerebral

catabolism of [3B]histamineafter (mice), 118

Adenylate cyclase, in striatal tin-

sue, activation by ethanol(mice), 129

Adrenergic blockade, beta, effectson renal and splanchic bloodflows during nicotine infusion(dogs), 363

Adrenergic receptors (see alsoAdrenoceptors)

agonists and antagonists, ef-fects on vesicourethral

smooth muscle (rabbits), 95a�pha-2, in isOlated islets of

Langerhans (rats), 607

beta, in submaxillary glands,

changes after reserpine orisoproterenol (rats), 419

Adrenoceptors (see also Adrener-

gic receptors)

alpha, agonist activity of do-butamine (rats, rabbits, dogs,guinea pigs), 210

aLpha, postsynaptic vascular,

variation in basilar and pal-

monary arteries (rabbits), 83alpha, presynaptic, in spleen

(cat), 162beta quinacrine-blocked desen-

itization after immobilizationstress and isoproterenol(rats), 334

classification into beta-i in-nervated and beta-2 hor-

monal receptors in atria(rats), 395

Airway smooth muscles, compar-ison of effects of ipratropiumbromide and diphemanilmethylsulfate on (guineapigs, cats), 1

Al-Turk, W. A., Stohs, S. J. andRoche, E. B.: Effect of hy-pophysectomy and castration

on hepatic, pulmonary andintestinal aryl hydrocarbonhydroxylase activities in therat, 492

Amethopterin, transport in jeju-num (rats), 329

Amidon, G. L and Buckner, C.K.: On the use of a dynamicapproach to the estimation ofdissociation constants for re-versible competitive antago-nists, 352

a-Aminoisobutyric acid, uptake inplacental villi, effects of cho-line acetyltransferase inhibi-

tom on (man), 232Amphetamine

comparison with tyramine andelectrical stimulation on do-

pamine release from caudatenucleus (rabbits), 592

interaction with drugs inhibit-

ing neurotransmission inspleen (cat), 162

d-Amphetamine, behavioral ef-fects, comparison with nico-tine (monkeys), 484

Amrinone, effects on sodiumtransport and cyclic AMPmetabolism in bladder (toad),220

Anderson, H. T., see Carp, J. S.,270

Angiotensin I, pressor responses,

effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L.Pro

and MK-421 on (guinea pigs,rats, dogs), 552

Angiotensin II, role of releasedcatecholamines in vascularresponse to (dog), 104

Antagonists, reversible competi-tive, use ofdynamic approachto estimation of dissociationconstants for (rats), 352

Antihypertensive agent (RO 12-4713), cardiovascular effects

(dogs), 624

Antihypertensive effects, of MK-421 (rats, dogs), 558

Antitumor agent, (acivicin), age-and sex-related toxicity(mice), 433

Antiviral agent, new (5-methoxy-methyl-2’-deoxyuridine), 275

Arbegast, P. T., see Sweet, C. S.,558

Arbilla, S., see Kamal, L A., 592Arrhythmias, ventricular, post-

myocardial infarction re-en-trant, suppression by bretyl-ium tosylate (dogs), 453

Arteries and veins, renal, compar-ison of dependence on cal-cium for responses to norepi-nephrine and potassium

(dogs), 239

Arterybasilar, involvement of adenine

nucleotides in sympatheticnerves of (dogs), 401

basilar and pulmonary, compar-ison of contractile responsesto sympathomimetic agonists(rabbits), 83

femoral, responses to vasodila-tor agents, effect of reserpinepretreatment (dogs), 447

Aryl hydrocarbon hydroxylaseactivity in liver, lung and intes-

tine, effect of hypophysec-tomy and castration (rats),

492of brain, characterization of

(rats, mice, guinea pigs, kites,crows, vultures, pigeons), 156

L-Asparagmase, from Escheria-chin coli, modification withmonomethoxypolyethyleneglycol (rats, mice), 410

Atkinson, A. J., Jr., see Ruo, T. I.,357

Atria, classification of beta-i in-nervated and beta-2 hor-monal adrenoceptors in(rats), 395

Autonomic nervous system (see

Nervous system, autonomic)

Axeirod, J., see Torda, T., 334

Backlund, E. P., see Gross, D. M.,552

Bannon, M. J., see Braszko, J. J.,

289

Barchas, J. D., see Edelman, A.M., 647

Barbieri, E. J., see Khanna, 0. P.,95

Baroreceptor reflex, alteration byan effect of propranolol onisolated carotid sinus (dogs),lii

Bashour, F. A., see Downey, H.F., 372

Beer, B., see Young, W. S. Ill, 434Behavior

discriminative stimulus proper-ties, evaluation of phencyci-dine analogs (rats), 543

effects of fixed ratio and dose

on methohexital-reinforcedresponding (rats), 205

schedule-controlled, effects oflevo-a-acetylmethadol andits metaboites on (pigeons),299

schedule-controlled, effects ofnaltrexone and naloxone on(monkeys, pigeons), 500

schedule-controlled, effects ofnicotine (monkeys), 484

self-administration of cocainederivatives (monkeys), 532

Benowitz, N. L, see Fredericks,

A. B., 247

Benzodiazepine receptors, locali-zation by light microscopicradiohistochemistry (rats),425

Bevan, J. A.: A comparison of thecontractile responses of therabbit basilar and pulmonary

arteries to sympathomimetic

agonists: Further evidence

for variation in vascular ad-renoceptor characteristics, 83

Bigger, J. T., Jr., see Davis, J. C.,39

Bioavailability and pharmacoki-

netics of acyclovir (dogs), 281

Biosynthesis, ofprostaglandins byhydronephrotic kidneys (rab-

bits, cats), 510Bladder

smooth muscle, effects of adre-nergic agonists and antago-mite on (rabbits), 95

urinary, effects of amrinone onsodium transport and cyclicAMP metabolism in (toad),220

Blood flowcerebral, effects of 5-hydroxy-

tryptamine (goats), 599

ischemic myocardial, effects ofsotalol and vagal stimulationon (dogs), 347

renal and splanchnic, duringnicotine infusion, effects ofbeta adrenergic blockade(dogs), 363

renal, effects ofprostaglandin 12and 6-keto-E1 (dogs), 24

Blood pressure, effects of �-9-te-

trahydrocannabinolon (mon-keys), 247

Bloom, F. E., see Schultz, J. E., 28Bloom, F. E., see Wiener, S. G.,

572

656 Index

Blum, M. R, see Krasny, H. C.,

281

Boccagno, J. A., see Voilmer, RR., 225

Bohn, D. L, see Gross, D. M., 552Bovine serum albumin, reversal of

inhibition of opiate receptorbinding by phospholipase A

(rats), 149Boyd, M. R. and Dutcher, J. S.:

Renal toxicity due to reactivemetabolites formed in situ inthe kidney: Investigations

with 4-ipomeanol in themouse, 640

Bradykinin, cardiovascular andsympathetic nerve responses

to (rats), 192

Brain (see also specific part)cerebral cortex, benzodiazepine

receptors (rats), 183characterization of aryl hydro-

carbon hydroxylase of (rats,mice, guinea pigs, kites,crows, vultures, pigeons), 156

decreased catabolism of [3H]-histamine after S-adenosyl-methionine administration(mice), 118

endogenous histamine, role incentral cardiovascular regu-lation (rats), 315

inhibition of opiate receptorbinding by phospholipase Aand reversal by bovine serum

albumin (rats), 149interaction of lisuride with so-

rotonergic and dopaminergicreceptors in (rabbits), 526

localization of benzodiazepinereceptors by light micro-scopic radiohistochemistry in

(rats), 425methionine sulfoximine epilep-

togemc, metabolism of 5-hy-droxytryptamine in (rats), 77

serotonin2 and histamine, re-

captors, Labeling with [3H]-mianserin (rat, guinea pig),142

Tyrosine hydroxylase, phos-

phorylation by cyclic AMP-dependent protein kinase

(cow), 647

Branch, R A., see Jackson, E. K.,24

Branch, R A., see Verbeeck, RK., 479

Braszko, J. J., Bannon, M. J.,Bunney, B. S. and Roth, R.H.: Intrastriatal kainic acid:Acute effects on electrophys-iological and biochemicalmeasures of nigrostriatal do-paminergic activity, 289

Breese, G. R, see Frye, G. D., 306Bretylium tosylate, suppression of

postmyocardial infarction re-entrant ventricular arrhyth-miss by (dogs), 453

Britt, P. M., see Sweet, C. S., 558

Bromberg, J. M., see Speier, S.,101

Bronchodilator agents, parasym-patholytic, ipratropium bro-

mide and diphemanil meth-ylsulfate, comparative study(guinea pigs, cats), 1

Bryan, L. J., Cole, J. J.,O’Donnell, S. R and Wan-stall, J. C.: A study designed

to explore the hypothesis

that beta-i adrenoceptors are“innervated” receptors andbeta-2 adrenoceptors are“hormonal” receptors, 404

Buck, J. D., Warltier, D. C., Hard-man, H. F. and Gross, G. J.:Effects of sotalol and vagalstimulation on ischemic myo-cardial blood flow distribu-tion in the canine heart, 347

Buckner, C. K., see Amidon, G.L, 352

Bu#{241}ag,R D., see Takahashi, H.,

192Bunney, B. S., see Braszko, J. J.,

289

Bush, E. N., see Voilmer, R. R,580

1,3-Butanediol, effects on central

nervous system, comparison

with ethanol (rats), 306Butyryicholinesterases, mono-

meric, from liver, inhibitionby chiorpromazine and otherdrugs (rabbit), 586

Calcium, binding and mobiliza-tion, comparison in renal ar-teries and veins (dogs), 239

Captopril (SQ 14,225), antihyper-tensive activity (dogs), 225

Cardiovascular effects, of Ro 12-4713 (dogs), 624

Cardiovascular regulation, cen-tral, role of histamine in(rats), 315

Cardiovascular responses, tobradykinin (rats), 192

Carp, J. S. and Anderson, R. J.:Modification of spinal cordtransmission by an interac-tion of chiorpromazine andphenytoin, 270

Castration, effect on hepatic, put-monary and intestinal aryl

hydrocarbon hydroxylase ac-tivities (rats), 492

Catabolism, decreased cerebral, of[3H]histamine after S-adeno-sylmethionine administra-

tion (mice), 118Catecholamines (see also specific

names)central, peripheral and gangli-

onic, effects of morphine on(rats), 321

released, role in vascular re.

sponse to angiotensin H(dog), 104

Cations, organic, transport in kid-ney plasma membrane veal-

des (dogs), 294

Cauvin, C. A., Devia, C. J. andKirkendol, P. L: Effect of re-serpine pretreatment on invivo femoral arterial re-

sponses to vasodilator agents,447

Cell R-15, neurosecretory, dopa-mine-sensitive receptor me-diating burst-firing inhibition

of (shellfish), 368Cells, capillary endothelial, sero-

tonin uptake by (rat), 125Cerebellum, effects oflithium and

tricyclic antidepressants onPurkinje cell discharge fre-

quency, norepinephrine re-sponses and beta receptorbinding in (rat), 28

Cerebrovascular effects, of 5-hy-droxytryptamine (goats), 599

Chang, J. K., see Pang, P. K. T.,567

Chapin, H. E., see Frye, G. D., 306

Chaturvedi, A. K., see Sastry, B.

V. R, 387

Chlorothiazide, effects on renal

tubular handling of uric acid(chickens), 441

Chlorpromazineinhibition of monomeric bu-

tyrylcholinesterases (rab-bit), 586

interaction with phenytoin,modification of spinal cordtransmission by (cats), 270

Choline acetyltransferaseinhibitors, effects on a-amino-

isobutyric acid uptake in pie-cental villi (man), 232

inhibitors, inhibition of spermmotility by (man), 378

Cholinergic system, in placental

(man), 232Cicero, T. J., see Owens, D. P.,

135Cimetidine, renal excretion of

(rats), 516Clarkson, T. W., see Dunn, J. D.,

19

Clearance, reduced, of modifiedEacherichia coli L-asparagen-

am (rats, mice), 410Clime, W. J., Jr.: Role of releasd

catecholamines in the vascu-lar response to injected an-giotensin H in the dog, 104

Clomde, effects on tolerance to

ethanol (rats), 459

Cocainederivatives, self-administration

(monkeys), 532

interaction with drugs inhibit-ing neurotransmission inspleen (cat), 162

Cole, J. J., see Bryan, L. J., 404Conjugation, and mixed-function

oxidation, postnatal develop-ment in hemoglobin-free per-fused liver (rats, puppies),473

Contractile responses, of basilarand pulmonary arteries tosympathomimetic agonists

(rabbits), 83Costa, E., see Karoum, F., 321Covalent binding, of[3H]doxorub-

icin (mice), 55

Crystal, G. J., see Downey, H. F.,372

Cyclic 3’ :5’-adenosine monophos-phate, accumulation by al-

Vol. 216

pha-2 adrenergic receptors inisolated islets of Langerhans(rats), 607

Cyclic AMP-dependent proteinkinase, phosphorylation of

tyrosine hydroxylase from

brain by (cow), 647

Das, M., Seth, P. K. and MUkhtar,

H.: Characterization of mi-crosomal aryl hydrocarbon

hydroxylase of rat brain, 156

Daum, A., see Gerold, M., 624

Davis, J. C. and Bigger, J. T., Jr.:The effects ofthioridazine onelectrical and ischemic yen-tricular fibrillation in the dogheart in situ, 39

de Miranda, P., see Krasny, H. C.,281

De Noble, V., see Pickers, H., 205Dependence, physical, on enka-

phalin analogs (rats), 12Dersham, G. H. and Han, J.: Ac-

tions of verapamil on Pur-kinje fibers from normal andinfarcted heart tissues, 261

Desethyl procainamide, metabo-

lite of procainamide, identifi-cation of (mice), 357

Desipramine, effects on discharge

frequency, norepinephrine

responses and beta receptor

binding in cerebellum (rat),28

Devia, C.J., see Cauvin, C. A., 447

Dewey, W. L, see Lamb, H. G.,496

Dexamethasone, effect on matu-ration of sympathetic neuro-transmission in heart (rat), 6

Diamond, L and O’Donnell, M.:

A comparative study of two

parasympatholytic broncho-dilator agents: Ipratropiumbromide and diphemanilmethylsulfate, 1

Dibona, G. F., see Osborn, J. L.,265

Dibutyryl cyclic AMP, effect ofreserpine pretreatment on

femoral arterial responses to(dogs), 447

Dieguez, G., GOmez, B. and Lluch,S.: Analysis of the cerebro-vascular effects of 5-hydroxy-tryptamine in unanesthetized

goats, 599

Diets, D. D., see Sellinger, 0. Z.,77

Diphemanil methylsulfate, corn-parison with ipratropiumbromide (guinea pigs, cats), 1

Dispositionof acivicin (mice), 433of [3H]doxorubicin (mice), 55

of furosemide, liver (dogs), 479of phenol red, effects of narcot-

ice on (mice), 90Dissociation constants, for revere-

ible competitive antagonists,use of dynamic approach to

estimation of (rats), 352Dobutamine

alpha adrenoceptor agonist ac-

1981 lndx 657

tivity of (rats, rabbits, dogs,guinea pigs), 210

Dopaminecell activity, nigrostriatal, ef-

fects of kainic acid on (rats),289

receptors, in brain, interactionwith lisuride (rabbits), 526

release from caudate nucleus,comparison of amphetamine,tyramine and electrical stim-

ulation (rabbits), 592-sensitive receptor mediating

burst-free inhibition of cellR-15 (shellfish), 368

Downey, H. F., Crystal, G. J. andBashour, F. A.: Regionalrenal and splanchnic blood

flows during nicotine infli-

sion: Effects of beta adrener-gic blockade, 372

[�H]Doxorubicin, pharmacoki-netics, covalent binding andsubcellular distribution of(mice), 55

Dubocovich, M. L, see Langer, S.z., 162

Dunn, J. D., Clarkson, T. W. andMagos, L: Interaction ofethanol and inorganic mer-cury: Generation of mercuryvapor in vivo, 19

Durant, N. see Lambert, J. J.,62

Dutcher, J. S., see Boyd, M. R,

640

Edelman, A. M., Reese, J. D., La-

zar, M. A. and Barchas, J. D.:Tyrosine hydroxylase: Stud-ies on the phosphorylation ofapurified preparation of thebrain enzyme by the cyclicAMP-dependent protein Id-

nase, 647

Eigenmann, R, see Gerold, M.,624

Elion, G. B., see Krasny, H. C.,281

Endotoxin-induced pyrexia, influ-ence on pharameokinetics ofgentamicin (rabbits), 415

End-plate conductance, in fran-

sected muscle, modification

by drugs (frog), 62Enkaphalin analogs, ability to

produce physical dependence

(rats), 12Enzyme

angiotensin converting, effectof N-[(S)-1-carboxy-3-phen-ylpropyl]-L-Ala-L-Pro andMK-421 on (guinea pigs, rats,

dogs), 552angiotensin converting, inhibi-

tion by captopril (dogs), 225angiotensin converting, inhibi-

tion by MK-421 (rats, dogs),558

Enzymes, hepatic drug metaboliz-ing, retrograde perfusion toprobe distribution of (rats),339

Eriaii, R, see Plante, G. E., 617Ethacrynic acid, effects on renal

tubular handling of uric acid(chickens), 441

Ethanolactivation of adenylate cyclase

in striata.l tissue by (mice),129

effects on central nervous sys-tern, comparison with 1,3-bu-tanediol (rats), 306

interaction with nutrition dur-lag gestation, influence onmaternal and offspring devel-opment (rats), 572

maternal consumption, inhibi-tion of placental valine up-

take after (rats), 465role in mercury exhalation

(mice), 19tolerance to, interactions with

pimozide and clonidine (rats),459

Excretionrenal, of cimetidine (rats), 516renal, oflevamisole (dogs), 617

Faulkner, G. D, see Rush, R S.,586

Ferko, A. P., see Mullin, M. J., 459Fibrillmion, ventricular, effect of

thioridazine on (dogs), 39[3H]Flunitrazepan, use in identi-

fication ofbenzodiazepine re-ceptors in cerebral cortex

(rats), 183Fredericks, A. B., Benowitz, N. L

and Savanapndi, C. Y.: Thecardiovascular and auto-nomic effects of repeated ad-ministration of �-9-tetrahy-drocannabinol to rhesusmonkeys, 247

Frye, G. D., Chapin, H. E., Vogel,H. A., Mailman, H. B., Kilts,C. D., Mueller, H. A. andBreese, G. R: Effects of acute

and chronic 1,3-butanedioltreatment on central nervoussystem function A compari-

son with ethanol, 306Fujiwara, M., see Muramatsu, I.,

410Furosemide

disposition in liver (dogs), 479effects on renal tubular han-

dling of uric acid (chickens),441

oxotoxicity of (chinchilla), 537

GalaCtOse, uptake into centrilob-tiler and periportal enriched

hepatocytes (rats), 634

Gardner, M. L, see Spealman, RD., 484

Gaul, S. L, see Sweet, C. S., 558Gentainicin, pharmacokinetics,

influence of endotoxin-in-duced pyrexia on (rabbits),415

Gerkens, J. F., see Jackson, E. K.,24

Gerkens, J. F., see Verbeeck, R.K., 479

Gerold, M., Eigenmann, R, Hefti,F., Daum, A. and Haeusler,G.: Cardiovascular effects of

a novel vasoactive antihyper-tensive agent, Ho 12-4713,

624Gertner, S. B., see Klein, M. C.,

315Gestation, interaction of ethanol

and nutrition during (rats),572

Gibson, J. K., see Patterson, E.,453

Girl, S. N., see Marafino, B. J., Jr.,55

Glands, submaxillary, changes inbeta adrenergic receptors

after reserpine or isoprotere-

not (rats), 419Goldberg, D. M., see Goldberg, S.

R,500

Goldberg, S. R, Morse, W. H. andGoldberg, D. M.: Acute andchronic effects of naltrexoneand naloxone on schedule-

controlled behavior of squir-rel monkeys and pigeons, 500

Goldberg, S. R, see Spealman, R

D., 484G#{243}mez, B., see Dieguez, 0., 599Gospe, S. M., Jr. and Wilson, W.

A., Jr.: Pharmacological stud-ies of a novel dopamine-sen-sitive receptor mediatingburst-firing inhibition of neu-rosecretory cell R-15 in Aply-ski californica, 377

Green, T. P., Rybak, L P., Mirkin,

B. L, Juliri, S. K. and Mori-

zono, T.: Pharmacologic de-terminants of ototoxicity offurosemide in the chinchilla,

537Gross, D. M., see Sweet, C. S., 558Gross, D. M., Sweet, C. S., Uhn,

E. H., Backlund, E. P., Mor-na, A. A., Weitz, D., Balm, D.

L, Wenger, H. C., Vassil, T.C. and Stone, C. A.: Effect ofN-[(S)-1-carboxy-3-phenyl-

propyl]-L-Ala-i.-Pro and itsethyl ester (MK-421) on an-giotensin converting enzyme

in vitro and angiotensin Ipressor responses in vivo, 552

Gross, F., see Khayyal, M, 399Gross, G. J., see Buck, J. D., 347Gupta, V. S., see Meldrum, J. B.,

275

Haeusler, G., see Gerold, M., 624

Halldn, H., Lidji, M. and Rubin-stein, E.: The influence ofendotoxin-induced pyrexiaon the pharmacokinetics ofgentan#{252}cin in the rabbit, 424

Han, J., see Dersham, G. H., 261Harden, T. K., see McCarthy, K.

D., 183Hardman, H. F., see Buck, J. D.,

347Heart

effects ofsotaloland vagal stim-ulation on ischemic myocar-dial blood flow in (dogs), 347

maturation ofsympathetic neu-retransmission in (rat), 6

mechanical performance and

electrical activity, effects ofadenosine (dogs), 254

muscle, effects of quinidine on(guinea pigs, cats), 176

postmyocardial infarction re-entrant ventricular arrhyth-miss, suppression by bretyl-ium tosylate (dogs), 453

ventricular fibrillation, effects

of thioridazine (dogs), 39Heart rate, effects of A-9-tetra-

hydrocannabinol on (mon-keys), 247

Heart tissues, normal and in-farcted, actions of verapamilon Purkinje fibers from(dogs), 261

Hechtman, H. B., see Robinson-

White, A., 125Hefti, F., see Gerold, M., 624Henderson, E. G., see Lambert, J.

J_, 62Henderson, G. I., Turner, D., Pa-

twardhan, R V., Lumeng, L,Hoyumpa, A. M. andSchenker, S.: Inhibition ofplacental valine uptake after

acute and chronic maternalethanol consumption, 465

Henthorn, T., see Ruo, T. I., 357Hepatocytes, centrilobuler and

periportal enriched, uptakeofgalactose, ouabain and tau-rocholate into (rats), 634

Heroin, self-administration, ef-fects of naltrexone (man), 45

Hen, A., see Schulz, R., 604

Herser, W. A., see Jackson, E. K.,24

Hester, R K. and Weiss, G. B.:Comparison of degree of de-pendence of canine renal ax-

teries and veins on high andlow affinity calcium for re-ponses to norepinephrine andpotassium, 239

Hirata, F., see Torda, T., 334Histamine, endogenous, role in

central cardiovascular regu-lation (rats), 315

[�H]Histamine, decreased core-bra! catabolism after S-ad-enosylmethionine adminis-

tration (mice), 118Histamine-N-methyltransferase,

inhibition by SKF 91488

(rats), 315Ho, I. K., see Nabeshima, T., 198Holland, M.-J. C., see Lin, H-K.,

149Holmberg, S., see Reingold, D. F.,

510

Holohan, P. D. and Roes, C. R:Mechanisms of organic cat-ion transport in kidneyplasma membrane vesicles: 2.�pH studies, 294

Honegger, U. E., see Reacher, A.A., 428

Horovitz, Z. P., see Voilmer, R.R., 225

HUYW1tZ, A.: Narcotic effects onphenol red disposition in

mice, 90Hoyumpa, A. M., see Henderson,

658 Index

G. I., 465Hydralazine

effect ofreserpine pretreatmenton femoral arterial responsesto (dogs), 447

in isolated renal artery, vasodi-lator effect of (rabbit), 390

Hydromorphine, effect on phenolred disposition (mice), 90

5-(p-Hydroxyphenyl)-5-phenyl-

hydantoin, interaction with

phenytoin and valproate(rats), 613

5-Hydroxytryptamine (see alsoserotonin)

cerebrovascular effects of(goats), 599

metabolism in methionine sal-foximine epileptogenic brain(rats), 77

Hyperlactatemia, effects of so-dium 2-chloropropionate on(dogs), 172

Hypertension, two-kidney model,

antihypertensive effect ofcaptopril (dogs), 225

Hypophysectomy, effect on he-patic, pulmonary and intes-

tinal aryl hydrocarbon hy-droxylase activities (rats),492

Hypotension, induced by sodium

nitroprusside, effects of die-tary sodium on role of reninangiotensin system duringand after (rats), 580

Hypotensive action, of syntheticfragments of parathyroidhormone (dogs, rats), 567

Hypothalamic-pituitary-luteiniz-

ing hormone axis, toleranceto effects of naloxone on(rat), 135

Imipramine, effects on discharge

frequency, norepinephrineresponses and beta receptorbinding in cerebellum (rat),28

Immunogenicity, reduced, ofmodified Escherichia coil L-

asparaginase (rats, mice), 410made, Y., see Kamisaki, Y., 419Infarction, myocardial, re-entrant

ventricular arrhythmiasafter, suppression by bretyl-

ium tosylate (dog), 453Insulin, release by aipha-2 adre-

nergic receptors in isOlated is-lets of Langenhans (rats), 607

Intestineeffect of hypophysectomy and

castration on aryl hydrocar-

hon hydroxylase activity in(rats), 492

small, HgCl2 inhibition of nutri-

ent transport in (fish), 70transit, interactions of reserpine

and morphine on (rats), 5214-Ipomeanol, metabolites, renal

toxicity by (mice), 640Ipratropium bromide, comparison

with diphemanil methylsul-fate (guinea pigs, cats), 1

Ishii, K., see Nakaki, T., 607

Islets of Langerhans, isolated, in-

sulin release and cyclic 3’:5’-adenosine monophosphateaccumulation by alpha-2 ad-renergic receptors in (rats),

607

Isoproterenolchanges in beta adrenergic re-

ceptors in submaxillaryglands after (rats), 419

effect of reserpine pretreatmenton femoral arterial responsesto (dogs), 447

quinacrine-blocked desensitiza-

tion of beta adenoceptorsafter (rats), 334

Jackson, E. K., Herzer, W. A.,Zimmerman, J. B., Branch,R A., Oaths, J. A. and Ger-kens, J. F.: 6-Keto-prosta-glandin E, is more potentthan prostaglandin 12 as arenal vasodilator and reninsecretagogue, 24

Jacoby, M., see Levine, S. D., 220James, T. N., see Urthaler, F., 254

Janson, V. E., see Sastry, B. V. R,387

Jejunum, transport of pteroylglu-

tamate and amethopterin in(rats), 329

Juhn, S. K., see Green, T. P., 537

Kainic acid, intrastriatal, effectson nigrostriatal dopaminecell activity (rats), 289

Kamal, L A., Arbilla, S. and Lan-ger, S. Z.: Presynaptic modu-lation of the release of dopa-mine from the rabbit caudatenucleus: Differences betweenelectrical stimulation, am-phetamine and tyramine, 592

Kamisaki, Y., Wads, H., Yagura,T., Mataushima, A. and In-

ada, Y.: Reduction in immu-nogenicity and clearance rateof Escherichia coli L-aspara-

ginase by modification withmonomethoxypolyethyleneglycol, 419

Karoum, F., Wyatt, R J. andCosta, E.: A comparativestudy on the effects of mor-

phine on central, peripheral

and gangliomc stores of cat-echolamines, 321

Kato, H., see Nakaki, T., 607

Kelleher, R. T., see Spealinan, R.

D., 532Kenakin, T. P.: An in vitro quan-

titative analysis of the alphaadrenoceptor partial agonist

activity of dobutamine andits relevance to inotropic so-

lectivity, 210Khanna, 0. P., Barbieri, E. J. and

McMichael, R F.: The effectsof adrenergic agonists andantagonists on vesicourethralsmooth muscle of rabbits, 95

Khayyal, M., Gross, F. and Kreye,V. A. W.: Studies on the di-rect vasodilator effect of hy-dralazine in the isOlated rab-bit renal artery, 399

Kidney

arteries and veins, dependenceon calcium for responses tonorepinephrine and potas-sium (dogs), 239

beta-i receptor mediation of reamsecretion from (dogs), 265

blood flow during nicotine in-fusion, effects of beta adre-nergic blockade (dogs), 363

effects of 4-ipomeanol meta-bolic activation (mice), 640

excretion of cimetidine (rats),516

excretion of levamisole (dogs),617

hydronephrotic, biosynthesis of

prostaglandins by (rabbits,cats), 510

involvement of prostaglandin 12

and 6-keto-E3 on ream secre-tion from (dogs), 24

isolated artery, vasodilator ef-fect of hydralazine in (rab-bit), 390

plasma membrane vesicles, or-ganic cation transport in(dogs), 294

tubular handling of uric acid,effects of furosemide, etha-crynic acid and chiorothia-ride (chickens), 441

Kilpatrick, B. F., see Rush, R. S.,586

Kilts, C. D., see Frye, G. D., 306Kinetics (see also Pharmacoki-

netics)of end-plate conductance, in

transected muscle, modifica-

tion by drugs (frog), 62Kirkendol, P. L, see Cauvin, C.

A., 447

Klaassen, C. D., see Stacey, N. H.,634

Klein, M. C. and Gertner. S. B.:Evidence for a role of endog-enous histamine in centralcardiovascular regulation: In-

hibition of histamine-N-methyltransferase by SKF 91

488, 315Koda, L. Y., see Wiener, S. G., 572Kopin, I. J., see Torda, T., 334Krasny, H. C., de Miranda, P.,

Blum, M. R. and Elion, G. B.:Pharmacokinetics and bioa-vailabiity of acyclovir in thedog, 281

Kreye, V. A. W., see Khayyal, M.,399

Kuehnle, J. C., see Mello, N. K.,45

Kuhar, M. J., see Young, W. S.ifi, 434

Lamb, R G. and Dewey, W. L:Effect of morphine exposureon mouse liver triglycerideformation, 496

Lambert, J. J., Durant, N. N.,Reynolds, L S., Voile, R Land Henderson, E. G.: Char-acterization of end-plate con-ductance in transected frogmuscle: Modification bydrugs, 62

Vol. 216

Langer, S. Z. and Dubocovich, M.L: Cocaine and amphet-amine antagonize the de-crease of noradrenergic neu-rotransmission elicited by ox-ymetazoline but potentiatethe inhibition by a-methyl-norepinephrine in the per-fused cat spleen, 162

Langer, S. Z., see Kamal, L A.,

592

Lau, C. and Slotkin, T. A.: Matu-ration of sympathetic neuro-transmission in the rat heart.VII. Suppression of sympa-thetic responses by dexa-methasone, 6

Laubscher, A., Pletscher, A. andNoil, H.: Interaction of D-

LSD with blood platelets ofrabbits: Shape change andspecific binding, 394

Lazar, M. A., see Edelman, A. M.,647

Lempert, N., see Speier, S., 101Levamisole, renal excretion of

(dogs), 617

Levine, S. D., Jacoby, M., Satri-ano, J. A. and &hlondorff,D.: The effects of amrinoneon transport and cyclic AMPmetabolism in toad urinarybladder, 220

Lidji, M., see Halkin, H., 424Light microscopic radiohisto-

chemistry, localization ofbenzodiazepine receptors by(rats), 425

IAn, H.-K., Holland, M.-J. C. andSimon, E. J.: Characteriza-tion of phospholipase A inhi-bition ofstereospecific opiatebinding and its reversal bybovine serum albumin, 149

Lippa, A. S., see Young, W. S. III,434

Lisuride, interaction with seroto-nergic and dopaminergic re-ceptors in brain (rabbits), 526

Lithium, effects on discharge fre-quency, norepinephrine re-sponse and beta receptorbinding in cerebellum (rat),28

Liverdisposition of furosemide in

(dogs), 479drug metabolizing enyzmes, ret-

rograde perfusion to probedistribution (rats), 339

effect of hypophysectomy andcastration on aryl hydrocar-boa hydroxylase activity in(rats), 492

inhibition by chlorpromazine ofmonomeric butyrylcholines-terases from (rabbit), 586

perfused, hemoglobin-free,postnatal development ofmixed-function oxidation andconjugation in (rats, pup-pies), 473

triglyceride formation, effect of

morphine exposure (mice),

496Lluch, S., see Dieguez, G., 599

1981 Index 659

Loubatieres-Mariani, M. M., seeRibes, G., 172

D-LSD, interaction with bloodplatelets (rabbits), 385

Lucchesi, B. R., see Patterson, E.,453

Ludden, C. T., see Sweet, C. S.,558

Lumeng, L., see Henderson, G. I.,465

Lung, effect of hypophysectomyand castration on aryl hydro-

carbon hydroxylase activityin (rats), 492

Magos, L., see Dunn, J. D., 19Mailman, R. B., see Frye, G. D.,

306Main, A. R, see Rush, R S., 586Makman, M. H., see Rosenfeld,

M. R., 526Marafino, B. J., Jr., Gin, S. N. and

Siegel, D. M.: Pharmacoki-netics, covalent binding andsubcellular distribution of[3H]doxorubicin after intra-venous administration in themouse, 55

Matsushima, A., see Kamisaki, Y.,419

McCarthy, K. D. and Harden, T.K.: Identification of two ben-zodiazepine binding sites oncells cultured from rat cere-bral cortex, 183

McGivney, W. T. and McMillan,D. E.: The effects of ievo-a-acetylmethadol and its me-tabolites on schedule-con-trolled behavior in the pi-geon, 299

McGovren, J. P., Neil, G. L, Sem,P. C. C. and Stewart, J. C.:Sex- and age-related mousetoxicity and disposition of theamino acid antitumor agent,acivicin, 433

McMichael, R. F., see Khanna, 0.P., 95

McMillan, D. E, see McGivney,

W. T., 299Mercury, exhalation, role of

ethanol (mice), 19Mercury chloride, inhibition of

nutrient transport in small

intestine (fish), 70Meldrum, J. B., Gupta, V. S., Ta-

neja, A. K. and Sisodia, C. S.:Pharmacological studies on5-methoxymethyl-2’-deoxy-uridine: A new antiviral

agent, 275Mello, N. K., Mendelson, J. H.,

Kuehnle, J. C. and Sellers, M.

S.: Operant analysis of hu-man heroin self-administra-tion and the effects of nut-trexone, 45

Mendelson, J. H., see Mello, N.K., 45

Metabolism

cyclic AMP, in bladder, effectsof amrinone (toad), 220

of 5-hydroxytryptamine in me-thionine sulfoximine epilep-togenic brain (rats), 77

Methadone, effect on phenol red

disposition (mice), 90

Methionine sulfoximine, effectson metabolism of 5-hydroxy-tryptamine in brain (rats), 77

Methohexital-reinforced re-sponding, effects of fixed ra-tio and dose (rats), 205

5-Methoxymethyl-2’-deoxyuri-dine, pharmacological studies

(mice, rats, rabbits), 275a-Methylnorepinephrine-in-

hibited neurotransmission in

spleen, effect of cocaine andamphetamine (cat), 162

Methylprednisolone sodium suc-ciiiate and phenytoin, effectson skin graft survival (mice),101

[3H}Mianserin, labeling of sero-tonin2 and histamine, recep-tore in brain (rat, guinea pig),142

Miller, D. S.: HgC1� inhibition ofnutrient transport in teleostfish small intestine, 70

Mirkin, B. L, see Green, T. P.,537

Miura, A., see Muramatsu, I., 410MK-421

antihypertensive activity of

(rats, dogs), 558effecton angiotensin converting

enzyme and angiotensin Ipresser responses (guinea

pigs, rats, dogs), 552Molinoff, P. B., see Rabin, R A.,

129

Monomethoxypolyethylene gly-col, modification of Esche-richia coil L-asparaginase

(rats, mice), 410Morita, Y., see Ruo, T. I., 357

Morizono, T., see Green, T. P.,537

Morphineeffects on central, peripheral

and ganglionic catechol-amines (rats), 321

effect on phenol red disposition(mice), 90

exposure, effect on liver triglyc-eride formation (mice), 496

interactions with reserpine onintestinal transit (rats), 521

Morris, A. A., see Gross, D. M.,552

Morse, W. H., see Goldberg, S. R,500

Motility index, ofsperm, effects ofinhibitors of choline acetyl-transferase (man), 378

Muchow, D., see Pickens, R., 205Mueller, R. A., see Frye, G. D.,

306Mukhtar, H., see Das, M., 156Mullin, M. J. and Ferko, A. P.:

Ethanol and functional to!.erance: Interactions with pi-mozide and clonidine, 459

Muramatsu, I., Fujiwara, M.,Miura, A. and Sakakibara, Y:Possible involvement of ade-nine nucleotides in sympa-

thetic neuroeffector mecha-nisms of dog basilar artery,

410Murthy, V. S., see Voilmer, R. R,

225Muscle

smooth, vesicourethral, effects

of adrenergic agonists andantagonists on (rabbits), 95

transected, end-plate conduct-ance, modification by drugs(frog), 62

Nabeshima, T. and Ho, I. K.:Pharmacological responses

to pentobarbital in different

strains of mice, 198Nakadate, T, see Nakaki, T., 607

Nakaki, T, Nakadate, T., Ishui, K.and Kato, R.: Postsynapticaipha-2 adrenergic receptors

in isolated rat islets of Lan-gerhans: Inhibition of insulinrelease and cyclic 3’:S’-aden-osine monophosphate accu-mutation, 607

Naloxoneeffects on hypothalamic-pitu-

itary-luteinizing hormoneaxis, tolerance to (rat), 135

effect on phenol red disposition(mice), 90

effects on schedule-controlledbehavior (monkeys, pigeons),500

Naltrexoneeffects on heroin seif-adminis-

tration (man), 45effects on schedule-controlled

behavior (monkeys, pigeons),500

Narcotics (see specific drug)

Nawrath, H.: Action potential,membrane currents and forceof contraction in mammalian

heart muscle fibers treatedwith quinidine, 176

Needleman, P., see Reingold, D.

F., 510Neil, G. L, see McGovren, J. P.,

433Nerve

sympathetic, of basilar artery,

involvement of adenine nu-cleotides (dogs), 401

sympathetic, responses tobradykinin (rats), 192

Nerve stimulation, renal, beta-i

receptor mediation of renin

secretion elicited by (dogs),

265

Nervous systemautonomic, effects of i�-9-te-

trahydrocannabinol on (mon.keys), 247

central, comparison of effects of1,3-butanediol and ethanol

(rats), 306central, interactions of chior-

promazine and phenytoin(cats), 270

sympathetic, maturation (rat),6

Neurotransmissionnoradrenergic, inhibited by

drugs, effects of cocaine andamphetamine (cat), 162

sympathetic, maturation in

heart (rat), 6Nicotine

effects on schedule-controlledbehavior (monkeys), 484

infusion, effects on renal andsplanchnic blood flows withand without beta adrenergic

blockade (dogs), 363Niehoff, D., see Young, W. S. IH,

434Nigrostriatal dopamine cell activ-

ity, effects of intrastriatalkainic acid on (rats), 289

Nitroglycerin, effect of reserpinepretreatment on femoral ax-

terial responses to (dogs), 447

Noll, H., see Laubscher, A., 394Norepinephrine

responses, in cerebellum, effectof lithium and tricyclic anti-depressants (rat), 28

responses, of renal arteries andveins, dependence on calcium(dogs), 239

N[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro, effect on anglo-tensin converting enzyme

and angiotensin I presser re-spouses (guinea pigs, rats,dogs), 552

Nutrient, absorption in small in-testine, inhibition by HgCl2(fish), 70

Nutrition, interaction with eth-

anol during gestation, influ-ence on maternal and off-spring development (rats),572

Oates, J. A., see Jackson, E. K., 24O’Donnell, M., see Diamond, L,

O’Donnell, S. R., see Bryan, L J.,404

O’Leary, T. D. and Sansom, L N.:Interaction between pheny-

toin, 5-(p-hydroxyphenyl)-5-phenyihydantoin and val-proate in the rat, 613

Osborn, J. L, Dibona, G. F. andThames, M. D.: Beta-i recep-tor mediation of ream secre-tion elicited by low-frequencyrenal nerve stimulation, 265

Ouabain, uptake into centrilobu-

lar and periportal enrichedhepatocytes (rats), 634

Owens, D. P. and Cicero, T. J.:Development of acute toter-ance to the effects of nalox-one on the hypothalamic-pi-tuitary-luteinizing hormoneaxis in the male rat, 135

Oxidation, mixed-function andconjugation, postnatal devel-opment in hemoglobin-freeperfused liver (rats, puppies),473

Oxotoxicity, of furosemide (chin-

cilia), 537

Oxymetazoline-inhibited neuro-transmission in spleen, effectof cocaine and amphetamine(cat), 162

Pang, K. S. and Terrell, J. A.:

660 Index

Retrograde perfusion toprobe the heterogeneous cbs-tribution of hepatic drug me-

tabolizing enzymes in rats,339

Pang, P. K. T., Yang, M. C. M.,Tenner, T. E., Jr., Chang, J.K. and Shimizu, M.: Hype-tensive action of syntheticfragments of parathyroidhormone, 567

Parathyroid hormone, synthetic

fragments, hypotensive ac-tions of (dogs, rats), 567

Patterson, E., Gibson, J. K. andLucchesi, B. R: Postmyocar-dial infarction re-entrantventricular arrhythmias inconscious dogs: Suppression

by bretylium tosylate, 453Patwardhan, R. V., see Hender-

son, G. I., 465Pentobarbital, pharmacological

responses in different strains

(mice), 198

Peroutka, S. J. and Snyder, S. H.:(3H]Mianserin: Differentiallabeling ofserotonin2 and his-tamine1 receptors in ratbrain, 142

Peterson, S., see Robinson-White,

A., 125

Petitclerc, C., see Plante, G. E.,617

Pharmacokinetics (see also Xi-netics)

and bioavailability of acyclovir(dogs), 281

of acivicin (mice), 433of [‘Hjdoxonibicin (mice), 55

of gentamicin, influence ofendotoxin-induced pyrexiaon (rabbits), 415

of 5-methoxymethyl-2’-deoxy-uridine (mice, rats, rabbits),275

of phenacetin and acetamino-phen, studied by retrogradeperfusion (rats), 339

Pharmacological responses, topentobarbital in different

strains (mice), 198

Phencycidine analogs, discrimi-native stimulus properties(rats), 543

Phenol red, disposition, effects ofnarcotics on (mice), 90

Phenothiazine, inhibition of mon-omeric butyrylcholinester-ases (rabbit), 586

Phenytoinand methylprednisolone so-

dium succinate, effects on

skin graft survival (mice), 101interaction with chlorproma-

zine, modification of spinalcord transmission by (cats),

270interaction with 5-(p-hydroxy.

phenyl)-5-phenylhydantoin

and valproate (rats), 613Phospholipase A, inhibition of

opiate receptor binding by(rats), 149

Phosphorylation, of tyrosine hy-

droxylase from brain by

cyclic AMP-dependent pro-tein kinase (cow), 647

Pickens, R, Muchow, D. andDeNoble, V.: Methohexital-reinforced responding in rats:Effects of fixed ratio size andinjection dose, 205

Pimozide, effects on tolerance to

ethanol (rats), 459Placental

isolated, cholinergic system in(man), 232

valine uptake, inhibition aftermaternal ethanol consump-

tion (rats), 465Plante, G. E., Erian, R and Petit-

clerc, C.: Renal excretion oflevamisole, 617

Plasma, membrane vesicles, kid-

ney, organic cation transport

in (dogs), 294Platelets, blood, interaction with

D-LSD (rabbits), 385Pletscher, A., see Laubscher, A.,

394Potassium, responses, of renal ax-

teries and veins, dependenceon calcium (dogs), 239

Procainamide, new metabolite(desethyl procainamide)(mice), 357

Propranolol, effects on isolated

carotid sinus (dogs), liiProstaglandin

byosynthesis by hydro-ne-

phrotic kidneys (rabbits,cats), 510

6-keto-E, and 12, effect on reninsecretion in kidney (dogs), 24

Pteroylglutamate, transport in je-junum (rats), 329

Purkinje fibers, from normal andinfarcted heart tissues, ac-tions of verapamil on (dogs),

261Pyrexia, endotoxin-induced, influ-

ence on pharmacokinetics ofgentamicin (rabbits), 415

Quebbemann,, A. J., see Shide-man,J.R.,441

Quinacrine-blocked desensitize-

tion of beta adrenoceptorsafter immobilization stress orisoproterenol (rats), 334

Quinidine, effects on heart muscle

(guinea pigs, cats), 176

Rabin, R A. and Molinoff, P. B.:Activation of adenylate cy-clam by ethanol in mousestriate! tissue, 129

Reese, J. D., see Edelman, A. M.,647

Receptorsbenzodiazepine, in cerebral cor-

tex (rats), 183benzodiazepine, localization by

light microscopic radiohisto-

chemistry (rats), 425beta-i, mediation of renin so-

cretion elicited by renal nervestimulation (dogs), 265

binding, beta, in cerebellum, ef-

fects of lithium and tricycic

antidepressanth (rat), 28dopamine, presynaptic in cau-

date nucleus (rabbits), 592dopamine-sensitive, mediating

burst-firing inhibition of cellR-15 (shellfish), 368

opiate, binding, inhibition byphosphoipase A and reversalby bovine serum albumin

(rats), 149serotonergic and dopaminergic,

in brain, interaction of lisur-ide with (rabbits), 526

serotonin2 and histamine, inbrain, labeling with [3H]-mianserin (rat, guinea pig),142

Reingold, D. F., Watters, K.,Holmberg, S. and Needle-

man, P.: Differential biosyn-thesis of prostaglandins byhydronephrotic rabbit andcat kidneys, 510

Reinke, L. A., see Sonawane, B.R., 473

Renin angiotensin system, roleduring and after sodium am-troprusside-induced hype-

tensin, effect of dietary so-dium on (rats), 580

Renmsecretion elicited by renal nerve

stimulation, beta-i receptormediation (dogs), 265

secretion from kidney, involve-ment of prostaglandin 12 and6-keto-E1 (dogs), 24

Reserpinechanges in beta adrenergic re-

ceptors in submaxillary

glands after (rats), 419interactions with morphine on

intestinal transit (rats), 521pretreatment, effect on femoral

arterial responses to vasodi-

lator agents (dogs), 447

Retrograde perfusion, to probedistribution of hepatic drugmetabolizing enzymes (rats),

339Reynolds, L S., see Lambert, J.

J.,62Ribes, G., Valette, G., Valette, J.

F. and Loubatieres-Mariani,M. M.: Sodium 2-chloropro-pionate: Its effects on exper-imental hyperlactatemia inthe dog, 172

Ho 12-4713, cardiovascular effects(dogs), 624

Robinson-White, A., Peterson, S.,Hechtman, H. B. and Shepro,D.: Serotonin uptake by iso-lated adipose capillary endo-

thelium, 125

Roche, E. B., see Al-Turk, W. A.,492

Reacher, A. A., Wiesmann, U. N.

and Honegger, U. E.:Changes in beta adrenergicreceptors in submaxillaryglands of chronically reser-pine- or isoproterenol-treatedrats, 428

Vol. 216

Rosenfeld, M. R and Makman,M. H.: The interaction of is-uride, an ergot derivative,with serotonergic and dope-minergic receptors in rabbitbrain, 526

Ross, C. R, see Holohan, P. D.,294

Roth, L., see Weiner, I. M., 516Roth, R H., see Braszko, J. J., 289Rowell, P. P. and Sastry, B. V. R.:

Human placental cholinergicsystem: Depression ofthe up-

take of a-aminoisobutyricacid in isolated human pta-cental villi by choline acetyl-transferase inhibitors, 232

Rubinstein, E., see Halide, H., 424Ruo, T. I., Morita, Y., Atkinson,

A. J., Jr., Henthorn, T. andThenot, J.-P.: Identificationof desethyl procainamide inpatients: A new metabolite ofprocainamide, 357

Rush, R. S., Main, A. R, Kilpa-trick, B. F. and Faulkner, G.D.: Inhibition of two mono-

meric butyrylcholinesterasesfrom rabbit liver by chiorpro-maxine and other drugs, 586

Rybak, L see Green, T. P., 537

Sakakibara, Y., see Muramatsu,

I.,410Sansom, L N., see O’Leary, T. D.,

613Sastry, B. V. It, Janson, V. E. and

ChaturVedi, A. K.: Inhibitionof human sperm motility byinhibitors of choline acetyl-transferase, 387

Sastry, B. V. R, see Howell, P. P.,232

Satriano, J. A., see Levine, S. D.,220

Savanapridi, C. Y., see Fredericks,A. B., 247

Schatz, H. A., Stramentinoli, G.

and Sellinger, 0. Z.: De-creased cerebral catabolism

of[’Hjhistamine in vivo after

S-adenosylmethionine ad-ministration, 118

Schenker, S., see Henderson, G.I., 465

Schiondorif, see Levine, S. D.,220

Sehocker, F. W., see Schultz, J.E., 28

Schults, H. D. and Zehr, J. E.:Alteration of the barorecep-tor reflex by an effect of pro-pranolol on the isolated ca-rotid sinus, lii

Schultz, J. E., Siggins, G. R,Schocker, F. W., Tilrck, M.and Bloom, F. E.: Effects ofprolonged treatment withlithium and tricycic antide-pressants on discharge fre-quency, norepinephrine re-sponses and beta receptorbinding in rat cerebellum:Electrophysiological and bio-chemical comparison, 28

1981 Index 661

Schulz, R, W#{252}ster, M. and Hen,A.: Pharmacological charac-

terization of the s-opiate re-ceptor, 604

Sellers, M. see Mello, N. K., 45Sellinger, 0. Z. and Diets, D. D.:

The metabolism of 5-hy-droxytryptamine in the me-thionine sulfoximine epilep-togemc rat brain, 77

Sellinger, 0. Z., see SChatZ, R A.,118

Sem, P. C. C., see McGovren, J.P., 433

Serotoninreceptors, in brain, interaction

with lisuride (rabbits), 526uptake by isolated adipose cap-

illary endothelium (rat), 125

Seth, P. K., see Das, M., 156

Shannon, H. E.: Evaluation ofphencycidine analogs on thebasis of their discriminativestimulus properties in the rat,543

Shepro, D., see Robinson-White,

A., 125Shideman, J. R, Zmuda, M. J.

and Quebbemann, A. J.: Theacute effects of furosemide,ethacryrnc acid and chloro-thiazid#{235} on the renal tubularhandling of uric acid in thechicken, 441

Shimizu, M., see Pang, P. K. T.,567

Shoemaker, W. J., see Wiener, S.G., 572

Siegel, D. M., see Marafino, B. J.,Jr., 55

Siggins, G. R., see Schultz, J. F.,28

Simon, E. J., see Lin, H.-K., 149Sinus, isOlated carotid, effects of

propranolol (dogs), liiSisodia, C. S., see Meldrum, J. B.,

275SKF 91488, inhibition of hista-

mine-N-methyltransferase(rats), 315

Skin graft survival, effects ofphenytoin and methylpred-nisolone sodium succinate

(mice), 101Slotkin, T. A., see Lau, C., 6Snyder, S. H. see Peroutka, S. J.,

142Sodium

dietary, effect on renin angie-tensin system during andafter sodium nitroprusside-

induced hypotensin (rats),580

transport in bladder, effects ofamrinone (toad), 220

Sodium 2-chloropropionate, ef-fects on hyperlactatemia(dogs), i72

Sodium nitroprusside-inducedhypotensin, effect of dietary

sodium on role ofrenin anglo-tensin system during andafter (rats), 580

Sonawane, B. R, Yaffe, S. J.,Reinke, L A. and Thurman,

a G.: Postnatal developmentof mixed-function oxidationand conjugation in hemoglo-bin-free perfused rat liver,473

Sotalol, effects on ischemic myo-cardial blood flow (dogs), 347

Spealman, R D. and Kelleher, RT.: Self-administration of co-caine derivatives by squirrel

monkeys, 532Spealman, R. D., Goldberg, S. R

and Gardner, M. L: Be-havioral effects of nicotine:Schedule-controlled re-

spending by squirrel mon-keys, 484

Speier, S., Bromberg, J. M. andLempert, N.: Phenytoin,methylprednisolone sodiumsuccinate and graft survival,101

Sperm motility, inhibition by in-hibitors of choline acetyl-transferase (man), 378

Spinal cord, transmission, modi-fication by an interaction ofchiorpromazine and pheny-toin (cats), 270

Spleen, perfused, effect of cocaineand amphetamine on inhibi-tion of neurotranamission in(cat), 162

Stacey, N. H. and Klaassen, C. D.:Uptake of galactose, ouabainand taurocholate into centri-lobular and periportal en-riched hepatocyte subpopu-

lations, 634Steinbacher, T. E., see Voilmer,

R. R, 225Stewart, J. C., see McGovren, J.

P., 433Stewart, J. J.: Interactions of re-

serpine and morphine on ratintestinal transit, 521

Stimulationelectrical, comparison with am-

phetamine and tyramine ondopamine release from cau-

date nucleus (rabbits), 592vagal, effects in ischemic myo-

cardial blood flow (dogs), 347

Stobs, S. J., see Al-Turk, W. A.,492

Stone, C. A., see Gross, D. M., 552

Stone, C. A., see Sweet, C. S., 558Stramentinoli, G., see SChatZ, R.

A., 118

Stress, immobilization, quina-crine-blocked desensitization

of beta adrenoceptors after(rats), 334

Striatum, activation of adenylatecyclase by ethanol in (mice),129

Strum, W. B.: Characteristics ofthe transport of pteroylglu-tamate and amethopterin inrat jejunum, 329

Sweet, C S., Gross, D. M., Arbe-gast, P. T., Gaul, S. L, Britt,

P. M., Ludden, C. T, Weitz,D. and Stone, C. A.: Anti-hypertensive activity of

N-[(S)- i-(ethoxycarbonyl)-3-phenypropyl]-L-Ala-L-Pro

(MK-42i), an orally activeconverting enzyme inhibitor,

558

Sweet, C. S., see Gross, D. M., 552

Sympathomimetic agonists, com-parison of contractile re-sponses of basilar and pal-monary arteries to (rabbits),83

Takahashi, H. and Bufiag, R D.:Centrally induced cardiovas-cular and sympathetic nerveresponses to bradykinin inrats, 192

Taneja, A. K., see Meldrum, J. B.,275

Taurocholate, uptake into centri-lobular and periportal en-riched hepatocytes (rats), 634

Tenner, T. E., Jr., see Pang, P. K.T., 567

Terrell, J. A., see Pang, K. S., 339�-9-Tetrahydrocannabinol, car-

diovascular and autonomiceffects of (monkeys), 247

Thames, M. D., see Osborn, J. L,265

Thenot, J.-P., see Ruo, T. I., 357

Thioridazine, effects on ventricu-tar fibrillation in heart (dogs),39

Thurman, R. G., see Sonawane,B. R, 473

Toleranceto effects of naloxone on hype-

thalamic-pituitary-luteiniz-ing hormone axis (rat), 135

to ethanol, interactions with pi-mozide and clonidine (rats),459

Torda, T., Yamaguchi, I., Hirata,F., Kopin, I. J. and Axelrod,J.: Quinacrine-blocked damn-sitization of adrenoceptorsafter immobilization stress orrepeated injection of isopro-

terenol in rats, 334Toxicity

renal, by 4-ipomeanol meta-bolic activation (mice), 640

sex- and age-related, of acivicin(mice), 433

Tricycic antidepressants (see

specific drug)Triglyceride formation, liver, ef-

fect of morphine exposure(mice), 496

T#{252}rck, M., see Schultz, J. E., 28Turner, D., see Henderson, G. I.,

465

Tyramine, comparison with am-phetamine and electricalstimulation on dopaminerelease from caudate nucleus(rabbits), 592

Tyrosine hydroxylase, brain,phosphorylation by cyclicAMP-dependent protein lii-nase (cow), 647

Ulni, E. H., see Gross, D. M., 552

Uric acid, effects of furosemide,

ethacryrnc acid and chloro-thiazide on renal tubular han-dling of (chickens), 441

Urthaler, F., Woods, W. T.,James, T. N. and Walker, A.A.: Effects of adenosine onmechanical performance andelectrical activity in the ca-nine heart, 254

Valette, G., see Ribes, G., 172Valette, J. F., see Ribes, G., 172Valine, placental uptake, inhibi-

tion after maternal ethanolconsumption (rats), 465

Valproate, interaction withphenytoin and 5-(p-hydrox-yphenyl)-5-phenylhydantoin

(rats), 613Vascular response, to angiotensin

H, role of released catechol-amines in (dog), 104

Vas deferens, pharmacologicalcharacterization of a-opiatereceptors in (rats), 604

Vasodilator, effect of hydralazinein isolated renal artery (rab-

bit), 390Vassil, T. C., see Gross, D. M., 552Veins and arteries, comparison of

dependence on calcium forresponses to norepinephrineand potassium (dogs), 239

Verapamil, actions on Purkinje fi-bers from normal and in-farcted heart tissues (dogs),261

Verbeeck, R K., Gerkens, J. F.,Wilkinson, G. R and Branch,R A.: Disposition of furose-mide in functionally hepatec-

tomized dogs, 479Vogel, R. A., see Frye, G. D., 306Voile, R. L., see Lambert, J. J., 62Voilmer, R R, Boccagno, J. A.,

Steinbacher, T. E., Horovits,z. P. and Murthy, V. S.: Anti-

hypertensive activity of cap-topril (SQ 14,225), an orallyactive inhibitor of angioten-sin converting enzyme in con-scious two-kidney perine-

phritic hypertensive dogs,225

Voilmer, R R, Bush, E. N. andAbukhres, M. M.: Influenceof dietary sodium on reninangiotensin system involve-ment in sodium nitroprussidehypotension in consciousrats, 580

Wads, H., see Kamisaki, Y., 419

Walker, A. A., see Urthaler, F.,254

Wanstall, J. C., see Bryan, L J.,404

Warltier, D. C., see Buck, J. D.,

347Watters, K., see Reingold, D. F.,

510Wei, E. T.: Enkephalin analogs

and physical dependence, 12Weiner, I. M. and Roth, L: Renal

excretion of cimetidine, 516

662 Index

Weiss, G. B., see Hester, R K.,239

Weitz, D., see Gross, D. M., 552

Weitz, D., see Sweet, C. S., 558Wenger, H. C., see Gross, D. M.,

552Wiener, S. G., Shoemaker, W. J.,

Koda, L Y. and Bloom, F. E.:Interaction of ethanol andnutrition during gestation:Influence on maternal and

offspring development in therat, 572

Wiesmann, U. N., see Roscher, A.A., 428

Wilkinson, G. H., see Verbeeck, RK., 479

Wilson, W. A., Jr., see Gospe, S.M., Jr., 377

Woods, W. T., see Urthaler, F.,254

)W#{252}ster,M., see Schulz, R., 604

Wyatt, R� J., see Karoum, F., 321

Yaffe, S. J., see Sonawane, B. R.,

473Yagura, T., see Kamisaki, Y., 419Yamaguchi, I., see Torda, T, 334

Yang, M. C. M., see Pang, P. K.T., 567

Young, W. S. Ill, Niehoff, D., Ku-liar, M. J., Beer, B. andLippa, A. S.: Multiple benzo-

Vol. 216

diazepine receptor localize-tion by light microscopic ra-

diohistochemistry, 434

Zehr, J. E., see Schultz, H. D., liiZimmerman, J. B., see Jackson,

E. K., 24Zmuda, M. J., see Shideman, J.

R, 441