741

INDEX

Volume 188, January-March 1974

Abboud, F. M., see $chmid, P. (1., 124

‘4C-Acetylchoiine, uptake and release in isolatedsynaptosomes, effect of narcotic analgesic

drugs, 419

Action potential of cat ventricle, effect of nico-tine, 157

Adanms, H. R., .�ee Goodnmarm, F. IL, 472Na�-K�-Adenosine t riphosphatase

binding and inhibition by cardiac giycosides in

rabbit myomet ri tim , dissociat ion fronm

contractile effect, 575

interactions of digoxin and ethacrynic acid with,

605Adrenergic blocking agent (s)

beta, effect on plasma reimin activity of COIISCiOIS

rabbit, 234

beta, propranolol, effect on ketamine-inducedreimiim release in rat, 229

Adreimergic nervefunction, effects of reserpine on, 654ternminais in guinea-pig atria, reserpine-resistaimt

norepinephrine store in, 668Adreimergic receptor

beta, aimtagonism in armesthetized dog, 357

block, alpha, relationship with inhibition of

norepinephrine uptake and release aimd

immetabolism of ‘H-norepinephrine , 368Adrenergic response, alpha, indirect, to isopro-

terenol iii dog spleen, 353Adreimergic vasoconst rid ion , inhibit ion by (luini-

dine, 124

Aghajaniaim, (l. K., see Haigler, H. J., 668

Alcohol, Imeilte and chronic administration, effect

on renal henmodvnanmics and nmonovalen

ion excretion, 461

Alprenoiol-treated cat ventricular muscles, effect of niCo-

tome on action potential of, 157-treated cat ventricular nmuscle, umot ropic

effects of nicotine, 148

Alvares, A. P., �ee Bickers, I). IL, 300

Alvin, J. and Bush, M. T. : The metabolic fate of

N , N’-di-nmet hoxvme� hyl-phenobarbit al in

1 he rat , 8

‘H--�.-.A.nminobutyric. acid, syrmaptosonmal 111)1 ake,regioimai differences and possii)le role ofexcimaimge processes, 429

3-(�-Anmiimoet hyl ) -1 , 2 , 4-t riazole , lust anmine rout�log, effects on cardia( coot ract iiitv , pimos-

phorylase act ival ion :111(1 cyclic adenosine

amoimophosphate i)loCked 1)� i)urinmanmide, 180

Aminophylline

effect on neuromuscular transmission in rat, 347

effect on removal of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386

Aminosalicylic acid, effects of salicylate andprobenecid on cerebrospinal fluid transport

of, 55Amphetamines, methoxylated, effects on dog

vascular strips, 114d-Amphet amine

conmparisons with pentobarbital aimd chior-

promazine on multiple and mixed schedules,

724effects on repeated acquisition of behavioral

chains, 700

rate-dependent effects, relationship to spatialand paw preferences iim rats, 714

Analog(s)of angiotensin , influence of sarcosine substituted

in position 1, 222

of histamine, effects on cardiac contractility,

phosphorylase activation and cyclic adeno-sine monophosphate blocked by burim-

amide, 180of vasopressiim (1 -deanmino-[8-D-arginine] -vaso-

pressin), antidiuretic action jim rats, 241

Aimdrogeim

assimilation by epitheliunm and muscle of guinea-

pig seminal vesicle, 324met abolism by liver microsonmes increased by

phenobarbitai, correlat ion wit h decreasedandrogen action oim rat seminal vesicies, 287

Angiotensinanalogs, influence of sarcosine substituted in

position 1, 222

effect of quinidine on vasoconstrictor responsesto, 124

Angiotensin TI-induced cormt ractile responses inrabbit aorta, effects of imeonmycin, 472

An t icoagulan t act ion , dist ri 1)Ut id)Im , elinminat ionand, of dicumarol, 293

Anticoimvuisant activity of propranolol and givcol

nietaboiite in rat , 86

Ant iditiret ic act ioim of 1 -deanmino-[8-o-arginine}-vasopressin in unanestimetized rats, 241

Antipyrine, eiimiimatioim 1�’ liver in imman, effects

of physical St ress on , 1

Almtd)nItccio, \I. J. and Simmith, C. B. : iffects of

chronic pretreatment witim simmall doses of

reserpine upon acirenergic nerve function,

668

742 INDEX Vol. 188

Antonaccio, M. J., see Van Orden, L. S., III, 654

Aorta, rabbit, effects of neonmycin on 45Ca move-

ments and contractile responses in, 472Aronson, B. S. and Gelles, J. M. : Electrophysio-

logical effects of dopamine on sheep cardiac

Purkinje fibers, 596Aspirin and actioim of leukocytic endogenous

mediator, 516Atria

guinea-pig, adrenergic nerve terminals, reser-pine-resistant norepinephrine store in, 668

guinea-pig, effect of reserpine on adrenergic

nerve function in, 654

guinea-pig, inotropic stimuli and systolic trarms-

membrane calcium flow in, 166

guinea-pig, release of norepinephrine by phenyl-

ephrine in, 640

Atropine , effect s on t hermoregulat.ion against

body cooliimg in conscious rabbit , 400

Autoradiographic dist ri but ion of ‘4C-hernicho-linium-3 in nmouse whole body and dog brain,

77

AY 22, 241 and At’ 22, 248, senmisynthetic cardiacgi ycosides with unique lactone linkage,actions compared in dog heart. with ouabain

and dihydro-ouabain, 189

Barbital, action in nmouse, potentiation by sodiumnitrite, 481

Barbiturate, potentiation in mouse by sodiumnitrite , role of nmet hemoglobin -induced hy-

poxia, 481

Barfknecht., C. F., see Cheng, H. C., 114

Barr, G. A., Cousins, M. J., Mazze, II. I., Hitt.,B. A. and Kosek, J. C. : A comparison of therenal effects and metabolism of enflurane

and methoxyflurane in Fischer 344 rats, 257Bassett, A. L. and Gelband, H. : Nicotine and the

action potential of cat ventricle, 157

Bassett., A. L. , Wiggins, J. H., Danilo, P., Jr.,Nilsson, K. and Geiband, H. : l)irect andindirect inotropic effects of nicotine on cat.

ventricular muscle, 148Bat, influence of �19-tetrahydrocannabinoi on

cardiovascular and subcut aneous micro-

circulatory systems in, 624

Baumei, I. P., Pitternman, A., Patel, (4., I)eFeo,J. J. and Lal, H. : Mechanisms underlyingpotentiation of barbiturate action by so�dium nitrite in the nmouse: The role ofmethemoglobin-induced hypoxia, 481

Beard, J. D., see Sargent, W. Q., 461

Belis, J. A., see Mawhinney, M. G., 324

Benzomethamine, absorption in rats treated

with antibiotics, 277Bertollini, A., see Levi, (1., 429Betazoie, histanmirme analog, effects on cardiac

cont ract ility , phosphorylase act ivat ion and

cyclic adenosine nmonophosphate blockaded

by burimamide, 180Bianchi, C. P. and Bolton, T. C. : Effect of hyper-

tonic solutions and “glycerol treatment”

on calcium and magnesium Immovements of

frog skeletal muscle, 536

Bickers, 1). IL, Kappas, A. aimd Alvares, A. P.:

1)ifferences in inducibility of cutarmeous and

Bile

hepatic drug nmetabolizing enzynmes andcytochronme P-450 by polychiorinated hi-

phenyls and 1,1,1-trichloro-2,2-bis(p-chlo-

rophenyl)ethane (1)1)T), 300

excret ion of morphine , nmorphine-3-glucuronide

and other compounds, effects of novobiocin,

504nman and dog, excretion of ouabain jim, 615

Bilirubin, effects of novobiocin on biliarv excre-

tion of, 504

Bloch, H., see Misra, A. L., 34

Blood, rat, distribution of hexobarbital in, 15

Blood pressure, after decarhoxylase iimhibition in

cat, effect of L-dOpa, 107

Blood urea nitrogen, in rabbits, effect of synthetic

salmon caicitonin, 318

Bolton, T. C., see Bianchi, C. P., 536

Braindog, autoradiographic distributioim of ‘4C-henmi-

cholinium-3 in, 77

dog, levels of bevo-nmethadone-1-’H irm, 34

synaptosonmes, rat, effect of narcotic analgesic

drugs on uptake and release of imeurotrans-mitters in, 419

synapt osomes , rat , upt ake of ‘H --y-anminobutyric

acid and ‘4C-glut amate, regional differencesand possible role of exchange processes, 429

Brown, 1). J., Miller, F. N., Longnecker, 1). E.,

Greenwald, E. K., Harris, P. I). and Forney,H. B. : The influence of A9-tetrahydrocan-nabinol on cardiovascular and subcutaneous

microcirculatory systems in time rat, 624

Bufotenine , action on 5-hydroxyt rypt amine re-ceptors in umbilical vasculature, 336

Bumpus, F. M., see Hall, M. M., 222

Burimamide, blockade of effects of histanmine andanalogs on cardiac contract ility , phos-phorylase activatioim and cyclic adenosine

monophosphate, 180

Burkhart, S. M., see Ledsonme, J. IL, 198

Bush, M. T.

see Alvirm, J., 8see Holcomb, R. H., 15

Butacaine, blockade of potassium exchange inmuscle by, comparison with SKF 525-A, 553

Butler, T. C., see 1)udlev, K. H., 491

But oxami ime , effect on isoproterenol -inducedresponses in anesthetized dog, 357

1974 INDEX 743

Calcitonin, synthetic salmon, effect oim glucose,blood urea nitrogen and serum electroiytesin rabbits, 318

Calciumflow, systolic t ransnmenmbrane, inot ropic st inmitii

and, in depolarized guinea-pig atria, 166

movements in frog skeletal muscle, effect of

hypertonic solut ions and ‘ ‘ glycerol t reat -

ment.,” 536Calcium-45, movements in vascular sinoothnmuscle,

effects of neomycin, 472

Carbachol, effect on cyclic adenosine monophos-phate in rabbit superior cervical ganglion,

676

Cardiac contractilityblockade by burimamide of effects of imistanmine

and analogs on, 180

effects of nicotine, 148

relationship to calcium flow in depolarizedguinea-pig atria, 166

Cardiac effects of histamirme and analogs blocked

by burinmamide, 180

Cardiac glycosidesbinding to rat. and rabbit myometrium, 582influence of position of attachmeimt. of lactone

ring to steroid nucleus on action of, 189inhibitioim and binding of Na�-K�-adeimosine

triphosphatase in rabbit myonmetriunm by,

dissociation from contractile effect, 575

Cardiovascular effectsof intracerebroventricular d-, 1- and dl-pro-

praimoiol in conscious rabbit, 394

of A9-tetrahydrocannabinol in bat, 624produced by purified scorpion toxin in rat , 207

Cardon, P. V., see Watanabe, A. M., 107

Cassano, Ci. B., see 1)onmino, E. F., 77

Cat(s)

effect of i�-dopa on blood pressure and sympa-thetic nerve activity after decarboxylase

inhibition iim, 107

effect of methyiguarmidine on norepinepimrinemetabolism in isolated, perfused spleen and

heart of, 93

effects of salicylate and probenecid on cerebro-spinal fluid transport of penicillin, amino-saiicyiic acid and iodide in, 55

nictit ating menmbrane, release of imorepinephrineby phenylephriime in, 640

pithed, nictitating membrane, sensitivity tob-norepinephrine after denervat ion or

decentralization, 630

prostaglandin inhibit ion of metabolically in-

duced coronary vasodilation in, 135

spleen, relationships between alpha receptorblock, inhibition of norepinephrirme uptakeand release and metabolism of ‘H-norepi-

nephrine in, 368

ventricle, effect of nicotine on action potential

of, 157

ventricular muscle, direct and indirect inotropiceffects of nicotine on, 148

Catecholamine

-induced changes in heart rate, antagonized bypropranolol, 198

-induced reiease of renal prostaglandin, relation

to renal endocrine function, 453

Central nervous systemdog, levels of levo-methadone-l-’H in, 34effects, metabolic disposition and, of glycol

metabolite of propranolol, 86

Cephaioridine, effect on uptake of 5-hydroxy-

indoleacetic acid by rat choroid plexus, 410

Cerebrospinal fluid

mode of elinmitmat ion of 5-hydroxyindoleaceticacid from, 410

transport of penicillin, amirmosalicylic acid and

iodide, effects of salicylate aimd probenecid,

55

Chen, J., see Levi, (1.,429

Cheng, H. C., Long, J. P., Nichols, D. E. andBarfknecht, C. F. : Effects of psychoto-mimetics on vascular strips: Studies ofmet hoxylat ed anmphet amines and opticalisomers of 2 , 5-dimet hoxy-4-methylamphet -

amine and 2 , 5-dimet hoxy -4 -bromoamphet -

amine, 114

a- and -y-Chlordane, effect on cyclic adenosine

3’ , 5’ -monophosphate -‘H formation by rat

kidney cortex, 265Chlordiazepoxide, effects on repeated acquisition

of behavioral chains, 700Chloride

excretion in dog, effect of acute and chronic

alcohol administration, 461serum, irm rabbits, effect of synthetic salmon

calcitonin, 318

Chlorpromazineabsorption in rats treated with antibiotics, 277

comparisons with d-amphetamine and chior-

pronmazine on multiple and mixed schedules,

724Choline acetylt ransferase, t raris-synaptic induc-

tion in pregangliormic neuron of peripheralsympat hetic nervous system , 439

Cholinergic receptor blocking drugs, central

effects on thermoregulation against bodycooling in conscious rabbit, 400

Choroid plexus, rat, acid transport system in, 410Clouet, I). H. and Wiliianms, N. : The effect. of

narcotic analgesic drugs on the uptake andrelease of neurotransmitters in isolated

synaptosomes, 419

Cocaineeffect on norepinephrine metabolism in isolated,

perfused cat spleen and heart , 93

744 INDEX Vol. 188

effect on removal of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386

effect on uptake and release of norepinephrine incat spleen , 368

Conney, A. H., see Levin, W., 287Contractile responses in vascular smooth muscle,

effects of neomycin, 472

Coronary vasodilat ioim , nmet abolically induced,prostaglandin inhibitiorm of, 135

Corticoids, giuco-, nmineralo- armd gluconmineralo-,pharnmacodynamic iimteract ions wit h various

drugs, 45

Corticosterone , interact ions wit h various drugs,45

Cousins, I�I. J., see Barr, G. A., 257

Cubeddu, ii., X., Langer, S. Z. and Weiner, N.:

The relationships between alpha receptorblock , inhibit ion of norepinephrine uptakeand time release aimd metabolism of ‘H-norepinephrine, 368

Cubeddu, L., X., Mosiimmanim, W. and Weiner, N.:The effect of nmethylguanidine on norepi-

nephrine umet aboiisnm in isolat ed , perfused

spleen and heart, 93

Cucinell, S. A, see Swartz, B. 1)., 1Cyclic adetmosine monophosphat e

blockade by burimanmide of effects of histamine

and analogs oim, 180

synaptically nmediated increase in rabbit

superior cervical ganglion, 676Cyclic adenosine monophosphate-’H fornmat ioim by

rat kidney cortex, effect of 1)l)T, 265

Cytochronme P-450, inducibility by polychlori-

nat.ed bipheimyls and 1)1)T, 300

Daniel, E. E., see Murtimy, IL V., 575, 582

Danilo, P., Jr., see Bassett, A. L., 148

1)a Silva, 0., see Szabo, S., 45

Dayton, P. (L, see Pruitt, A. W., 248

D1)T [1 , 1 , 1-t richloro-2 , 2-his (p-chiorophenyl)-eth-ane]

effect on cyclic adenosine 3’ , 5’ -Immonophosphate-

‘H formatioim by rat kidney cortex, 265iimducibiiitv of cutaimeous and hepatic drug

nmetaboiizing eimzynmes and cytochrome P-450 by, 300

1 -Deamino-[8-o-argiimiime]-vasopressin, ant idiuret ic

action in unaimesthetized rats, 241Decarboxylase inhibition in cats, effect of i�-dopa

Oil blood pressure and sympathetic imerve

activity after, 1071)eFeo, J. J., see Batimel, I. P., 481

l.)esoxvcort icosterone acet ate , interactions with

various drugs, 451)ext.rorphan, effect Oil uptake and release of

neurot ransnmitters iim isolated syrmaptosomes,

419

Diazoxide, nietabolism in man and experinmental

animals, 248

1)ibutyryl cyclic adenosine monophosphate, ef-

fects cam neuronmuscular transnmission in rat.,447

l)icunmarol , dist ribution , elinminat ion aimd armti-

coagulant action of, 293

1)ieidrin, effect on cyclic adenosine 3’,S’-nmono-

phosphate-’H fornmat.ion l)y rat kidneycortex, 265

$-l)iet imylaminoet hyl dipheimylpropyiacet ate (see

SKF 525-A)

1)igitoxin

effects of novobiocirm on hiliary excretiorm of, 504inhibition and binding of Na�-K�-adeimosirme

t riphosphat ase in rabbit myonmet riuimm by,

dissociation from contractile effect, 5751)igoxin

bindiimg irm rabbit armd rat rmm.yonmetriunm, 582

interact ion with renal Na-K�-adenosiime tn-phosphatase, 605

met abolisnm iim hypokalenmic aimd nornmokaieniic

dogs, effect of irmsuiin and glucose, 564Dihydroergot amine, effect on Sch islosonia n)anson.i,

529

l)ihydro-ouabain, ouabain and, act ions iim clogheart compared wit h semisynthet ic cardiacgiycosides, 189

2 , 5-1 )imethoxy-4-bronmoanmphetanmine, opticalisomers, effects Ofl dog vascular strips, 114

2 , 5-i)imet hoxy-4 -nmet hylanmphet ainirme , opticalisomers, effects on dog vascular strips, 114

1)iimmet hyiphenylpiperaziniurim , interact ioim with

prostagiandin 1 � in c�it heart , 135l)iphenylhydant oiim , ahsorpt iorm in rats tneate(l

� antibiotics, 277

Dog(s)

ai)iiitv of pr�pranol�i to antagormize in(luced

changes in imeart rate irm, 198

acutely hvpokaiem i c and normokalemic , effectof insulin and glucose on nmyocardial andskelet al nmuscie upt tke of digoxiim in , 564

anesthetized, bela adrenergic receptor antago-

nism in, 357brain, autoradiographic distribution of ‘4C-

hemichoiiniunm-3 in, 77heart , cormmpanison of nat oral and seimmisynt imet ic

cardiac glycosides in, 189inhibition of adrenergic vasocoimst net ion by

quinidine in, 124inhibitory effect of i��i�phl�retiii phosphate on

platelet aggregat iOim and henmodynanmic andrespiratory changes caused by timroimmhin and

protamine in, 214interactions of digoxin and ethacrynic acid with

renal Na � J� � -:ldlenosine t niphosphatase in,

605

1974 INDEX 745

metabolism of diazoxide in, 248physiological disposition and biotransformation

of levo-nmethadone-1-’H in, 34

reimai and gastrointestinal excretion of ouabain

in, 615spleen, indirect alpha adrenergic respoimse to

isopnoterenoi in, 353

vascular strips, effects of psychotominmeticanmphetamiimes on, 114

Dollery, C. T., see Reid, J. L., 3941)onmino, E. F., Cassano, G. B. and Placidi, (1.-F.:

Autoradiographic distribution of ‘4C-hemi-choliimium-3 in mouse whole body and dog

brairm, 77

L-Dopa, effect on blood pressure atmd sympathetic

nerve act ivit y after decarboxylase iimhibi -

tion iim cats, 1071)opamine, electrophysiological effects oim sheep

cardiac Purkinje fibers, 596

‘4C-Dopamine, uptake and release in isolatedsynaptosomes, effect of narcotic analgesic

drugs, 419Douglas, J. II., Jr., see Needlenmalm, P., 453Drug interactioims

among glucominenalocont icoids , pregnenolone -

16a-carbonitnile and various drugs, 45

digoxin and ethacrynic acid with renal Na�-K�-adenosine tniphosphatase, 605

Drug-receptor reaction, adsorption isotherimm us.

ion-exchange models for, 520

Dudley, K. H., Butler, T. C. aimd Johimsoim, D.:Chemical studies of potential relevaimce to

penicillin hypersensitivity : Kitmetic st tidies

of methicillin, phenoxymethylpeimiciliin andtheir penicillenic acids, 491

1)yer, I). C. : Fvidence for the actiorm of (1-lysergic

acid diethylanmide, mescaline and bufote-nilme on 5-hydroxytryptanmine receptors inumbilical vasculature, 336

Electrolytes, seruimm, in rabbits, effect of syrmthetic

salmon calcit.onin, 318Electrophysiological effects of dopamiime on sheep

cardiac Purkinje fibers, 596

Endnin, effect on cyclic adenosine 3’,S’-nmono-phosphate-’H formation by rat kidney

cortex, 265Enfiuirane, renal effects and nmetabolisnm in Fischer

344 rats , comparison wit h nmet hoxyflurane,

257Enzymes, drug metabolizing, cutaneous and

hepatic, inducibility by polychiorinated

biphenyis and .L)DT, 300(- )-‘4C-Ephednine, accunmulation by pigmented

and nonpigmented iris, 342Epinephnine-induced release of renal prosta-

glandin, relation to renal function, 453

Etimacrynic acid , interactiorm with renal sodium-

pot assium -act ivated adenosine t niphospha-

tase, 605

Ethanol, pentobarbital and, differential effects on

sleep time in C57BL and BALB mice, 27Exchange processes, possible role in regioimal dif-

ferences in synaptosomal uptake of ‘H-

y-anminobutynic acid and “C-glut aimmate, 429

Faraj, B. A., see Pruitt, A. W., 248

Feller, D. II., see Patil, P. N., 342Feisenfeld, A. J., see Park, J. P., 353

Fluorocortisol acetate , interactions with various

drugs, 45

Forney, II. B., see Browim, 1). J., 624Francis, D. J., Georoff, M. E., Jackson, B. and

Marcus, F. I. : The effect. of insuliim andglucose on the nmyocardial and skeletalrmmuscle uptake of tritiated digoxirm in acutely

imypokalenmic and normokalenmic dogs, 564Franco, I. , see Freire-Maia, L. , 207

Freire-NIaia, L. , Pinto, G. I. and Franco, I.:Mechanism of the cardiovascular effects

produced by purified scorpion toxin in therat, 207

Frog

immuscle, blockade of potassium exchange bySKF 525-A irm, conmpanison with butacaine,

553skeletal nmuscle, effect of hypertonic solutions

and “glycerol treatnment” on calcium and

Immagimesituim nmovenmeimts of, 536

Frohnman, L. A., see Goldnman, J. II., 310

Fujinmoto, J. 1\�I., see Snmith, 1)., 504

(iaffimey, T., see Saelens, D. A., 86

Ganglion , rabbit superior cervical , synapticallymediated cyclic adetmosine immonopimosphateirmcrease irm, 676

Gelbaimd, H., see Bassett, A. L., 148, 157

(ielles, J. M., see Aronson, H. S., 596

Georoff, � E., see Francis, D. J., 564

Gerber, N., see Holcomb, II. II., 15

Giant axons, squid, effect of strychnine on ionicconductances of, 66

Gillis, C. N., see Twasawa, Y., 386

Glick, S. D. armd Jerussi, T. It. : Spatial and pawpreferences in rats: Their relationship to

rate-dependent effects of (l-anmphetanmine,

714

Glucocorticoid admirmistration to rats, effects on

in vitro intermediary metabolisnm, 310

Glucose

effect. on nmyocardial and skeletal nmuscle uptakeof digoxin in acutely hypokalenmic and

normokalemic dogs, 564

746 INDEX Vol. 188

in rabbits, effect of synthetic salmon calcitonin,

318

metaboiisnm in rat., effects of glucocorticoids, 310‘4C-Glut anmat e , synapt osonmal tipt ake , regional

differeimces and possible role of exchangeprocesses, 429

“Glycerol treatnment,” effect orm calcium and mag-nesiuni movements of frog skeletal muscle,

536

Glycosides, cardiac (see Cardiac glycosides)

Goldman, J. H. and Frohman, L. A. : Effects ofglucocorticoid administration to rats on in

vitro intermediary met abolism, 310Goodman, F. II., Weiss, (1. B. and Adams, H. IL:

Alterations by neomycin of 45Ca movementsand coimtractile responses in vascular

smooth muscle, 472Goodwin, 1). W., see Hill, S. Y., 415

Greengard, P., see Kalix, P., 676

Greenwaid, E. K., see Brown, D. J., 624

Guinea pig

atria, adrenergic nerve terminals, reserpine-

resistaimt norepinephrine stores in, 668

atria, effect of reserpine on adrenergic nerve

furmction irm, 654

atria, inotropic stimuli and systolic transmem-

brane calcium flow in, 166

atria, release of imorepinephrine by phenyl-

ephrine in, 640

heart , blockade by burimamide of effects ofhistamine and analogs on, 180

metabolism of diazoxide in, 248

pigmented and nonpigmented iris, accumulat ionof (-)-‘4C-ephedrine by, 342

seminal vesicie, androgen assimilation by

epithelium and muscle of, 324

Guntheroth, W. G., see Park, J. P., 353

Haigler, H. J. and Aghajanian, (i. K. : Lysergic

acid diet.hylamide and serotonin : A corn-parison of effects on serotonergic neurons

and neurons receiving a serotonergic input,

688

Hall, M. � Khosla, M. C., Khairailah, P. A. andBumpus, F. M. : Angiotensin analogs: The

influence of sarcosine substituted in position1, 222

Hallucinogens, actions on sheep umbilical ar-teries, 336

Harris, P. 1)., see Browim, D. J., 624

Heart

dog, conmparison of natural and semisynthetic

cardiac glycosides in, 189

dog, levels of bevo-methadone-1-’H in, 34

guinea-pig, blockade by burirnamide of effectsof histamine and analogs on, 180

in acutely hypokalemic and nornmokalemic dogs,

uptake of digoxin in, effects of insulin aimd

glucose, 564isolated, perfused, effect of methylguanidine on

norepinephrirme met abolism in , 93

sheep , Purki nj e fibers , elect rophysiologicaleffects of dopamine on, 596

Heart rate, ability of propranolol to aimtagonizeinduced changes in, 198

Heistad, D. I)., see Schrnid, P. G., 124

‘4C-Hemicholinium-3, autoradiographic distribu-

tion in nmoiise whole body and dog brain, 77Hemodynanmic changes, caused by thrombin and

protamine, inhibitory effect of poly-

phloretin phosphate, 214

Henderson, E. G. and Voile, H. L. : Asymmetricalblockade of potassiunm exchange in muscle

by SKF 525-A: Conmparison with butacaine,

553Heptachior, effect on cyclic adenosine 3’,5’-mormo-

phosphate-’H formation by rat kidney

cortex, 265

Hexarnet honium , effect s on t hermoregulat ion

against body cooling in conscious rabbit,400

Hexobarbital

action in mouse, potentiation by sodium nitrite,

481

nmetabolic fate in rat, 15

Hill, S. Y., Schwin, H., Goodwin, D. W. andPowell, B. J. : Marihuana and pain, 415

Hiilrnan, G. it, Olsen, N. J. and Senft, A. W.:Effect of niethysergide and dihydroergot-

amine on Schistosonia mansoni, 529

Histamineand analogs, effects on cardiac contractility,

phosphorylase activation and cylic aden-

osine monophosphate blocked by burirn-

amide, 180-iimduced coimtractile responses in rabbit. aorta,

effects of neomycin, 472

Hitt, B. A., see Barr, G. A., 257

Holcomb, li. IL, Gerber, N. and Bush, M. T.:The metabolic fate of hexobarbitai in the

rat, 155-Hydroxyindoleacetic acid, mode of elimination

from cerebrospinai fluid, 410

5-Hydroxyt rypt amine (see also Serotonin)effect of quinidine on vasoconstrictor responses

to, 124

receptors in dog vascular strips, effects of

psychotomimetic amphetamines, 114

receptors in umbilical vasculature, action ofLSD, mescaline and bufotenine on, 336

removal from puimotmary circulation, effect. of

drugs, 386Hypertonic solutions, effect on calcium and mag-

nesium movements of frog skeletal muscle,536

1974 INDEX 747

Jackson, B., see Francis, 1). J., 564

J#{228}hnchen, 1’�. and Levy, (1. : Relationship between

Hypoxia , nmet henmoglobi im-iimduced , role in po-tentiation of barbiturate action by sodiumnitrite in nmouse, 481

Tmipramine, effect oim removal of norepineplmrineand 5-hydroxytryptanmine from rabbit lung,

386

Inagaki, C., see Martinez-Maldonado, M., 605

Indocyanine green, elinminatiorm by liver in man,

effects of physical stress on, 1

Indoleacetic acid, effect on uptake of 5-hydroxy-

indoleacetic acid by rat choroid plexus, 410

Inotropic effects, direct and indirect, of nicotitme

on cat ventricular nmuscle, 148

Inot ropic st imuli, syst olic transnmenmbrane calciunmflow and, in depolarized guinea-pig atria,

166

Insect icides, halogenated hydrocarbon , effect. on

cyclic adenosine 3’ , 5’ -monophosphat e -‘Hformation by rat. kidney cortex, 265

Insulin, effect on nmyocardial and skeletal nmuscie

uptake of digoxin in acutely hypokalemicand normokalemic dogs, 564

Intestinedog, levels of levo-nmethadone-1-’H in, 34small, rat, effect of armtibiotics on drug absorp-

tion from, 277

Iodide, effects of salicylate and probenecid oncerebrospinal fluid transport of, 55

Ton, monovalent, excretion, effect of acute aimdchronic alcohol adnministration on, 461

Ion-exchange models, us. adsorption isothernm fordrug-receptor reaction, 520

Ionic conductances of squid axon nmenmbrane,

effects of strychnine, 66

Iris, pigmented and imoimpigmented, accunmulat ionof (-)-14C-ephedrine by, 342

Isoproterenol

cardiac effects in depolarized guinea-pig atria,

166

indirect alpha adrenergic response in dog spleen

to, 353

-induced cardiovascular responses in anes-

thetized dog, effects of beta adrenergic

receptor blocking agents, 357-induced changes in heart rate, antagonized by

propranoiol, 198

interaction with prostaglandin E1 iii cat heart,

135

Iwasawa, Y. and (lillis, C. N. : Pharmacological

analysis of norepinephrine and 5-hydroxy-tryptanmine removal from the pulmonary

circulation : 1)ifferentiation of uptake sitesfor each anmine, 386

distribution , elimination aimd aimticoagulant

action of dicumarol, 293Jakschik, B., see Needieman, P., 453Jerussi, T. P., see Glick, S. I)., 714

Johnson, 1)., see Dudley, K. H., 491

Johnson, E. M., Jr., see Needleman, P., 453

Judy, W. V., see Wat.anabe, A. M., 107

Kabela, E., see Mendez, It., 189

Kacew, S. aimd Singhal, H. L. : Effect of certainhaiogenat ed hydrocarbon insect icides on

cyclic adenosine 3’ , 5’ -nmonophosphate-’H

formation by rat kidney cortex, 265

Kalix, P., McAfee, I). A., Schorderet, M. and(.reengard, P. : Pharmacological analysis of

syimapticaliy nmediated increase in cyclic

adenosine monophosphate in rabi)it superior

cervical gaimglion, 676Kanmpschrnidt, H. F., see Merrinman, C. H., 516

Kappas, A., see Bickers, D. IL, 300Kellett , H. P., see Ledsome, J. H., 198

Ket amine-induced cardiovascular Stimulation,renism release and, in rat, 229

Khairallaim, P. A., see Hall, M. 1�I., 222

Khosla, M. C., see Hall, M. M., 222

Kidneycortex, rat , effect of halogenated hydrocarbon

insecticides on cyclic adenositme 3’,5’-mon-ophosphate-’H formation by, 265

dog, levels of levo-nmethadone-1-’H in, 34

rat, distribution of hexobarbital in, 15

Kidwai, A. M., see Murthy, H. V., 575, 582Kimapp, 1). IL, see Saeiens, 1). A., 86Kosek, J. C., see Barr, G. A., 257Kourounakis, P., see Szaho, S., 45

Krejl�i, I., see V#{225}vra,I., 241

Kuhn, W. L., see Tsai, T. H., 630

Lactoime ring, position of attachnment to steroidnucleus as influence on action of cardiac

giycosides, 189

Lal, H., see Baumel, I. P., 481

Langer, S. Z.see Cubeddu, L., X., 368

see Luchelli-Fortis, lvi. A., 640Leander, J. 1). and McMiilan, D. E. : liate-de-

pendent effects of drugs. I. Conmparisons of(/-amphetamine, pentobarbital and chlor-

promazine on multiple and nmixed schedules,724

Ledsome, J. IL, Keilett, H. P. and Burkhart, S.M. : The ability of propranolol to antagonizeinduced changes in heart rate, 198

Lester, 1)., see Randall, C. L., 27Leukocytic endogenous mediator, actioim of, pros-

tagiandin, aspirin and, 516Levi, (4., Bertoilini, A., Chen, J. and ilaiteri, M.:

Regional differences in the synaptosomai

748 INDEX Vol. 188

uptake of ‘H--y-aminobutyric acid and ‘4C�

glutamate and possible role of exchangeprocesses, 429

Levin, W., Welch, H. M. and Conney, A. H. : In-creased liver microsomal androgen metabo-

lism by phenobarbital : Correlation withdecreased androgen action on the seminal

vesicles of the rat, 287

Levine, H . IL, see Walsh, C. T., 277Levorphanol, effect. on uptake and release of

neurotraimsmit.ters in isolated synaptosomes,419

Levy, B., see Wasserman, M. A., 357Levy, G., see J#{228}hnchen, E., 293Lewis, P. J., see Reid, J. L., 394Lincomycin-treated rats, drug absorption in, 277

Liverdog, levels of levo-methadone-1-’H in, 34man, effects of physical stress on disposition of

drugs eliminated by, 1microsomal androgen metabolism increased by

phermobarbit al , correlat ion with decreased

androgen action on rat seminal vesicles, 287rat., distribution of hexobarbital in, 15rat , enzyme and cytochrome P-450 induction by

polychiorinated biphenyls and DDT, 300

Lloyd, J. W., see Mawhinney, M. G., 324Long, J. P., see Cheimg, H. C., 114

Longnecker, D. E., see Brown, 1). J., 624

Lorenzo, A. V., see Spector, R., 55LSD

action on 5-hydroxyt ryptamine receptors inunmbiiical vasculature, 336

effects on serotonergic neurons, comparison with

serotonin, 688Lucheili-Fortis, M. A. and Langer, S. Z. : Heser-

pine-induced depletion of t he norepineph-

rine stores: Is it. a reliable criterion for the

classification of the mechanism of action of

synipathomimetic amines, 640

Lungdog, levels of levo-methadorme-1-’H in, 34

rabbit, effect of drugs on removal of Imorepi-imephrine and 5-hydroxytryptamine from,

386Lupulescu, A. : F�ffect of synthetic salnmon cal-

citoimin mm glucose, blood urea nitrogen aimd

serunm electrolytes in rabbits, 318

d-Lysergic acid diethylamide (see LSD)

Machov#{225}, A., see V#{225}vra,I., 241

Magnesi iiimmimmovenmeimts in frog skeletal nmuscle, effect of

hypertoimic soliit iorms and ‘ ‘ glycerol t reat -rnent,’’ 536

serunm, iim rabbits, effect of synthetic salmon(alcitonin, 318

Malspeis, I.., see Patil, P. N., 342

Man

effects of physical stress on disposition of drugseliminated by liver in, 1

inhibition of adrenergic vasoconstriction by

quinidine in, 124marihuana and pain in, 415

metabolism of diazoxide in, 248

renal and gastrointestinal excretion of ouabainin, 615

Marcus, F. I., see Francis, I). J., 564

Margolies, M. N., see Selden, R., 615Marihuana and pain, 415

Mark, A. L., see Schmid, P. G., 124Martinez-Maldonado, M . , Tsaparas, N . , Inagaki,

C. and Schwartz, A. : Interactions of digoxin

and ethacrynic acid with renal sodium-

potassium -activated adenosine triphos-

phatase, 605

Mawhinney, M. G., Schwartz, F. L., Thomas, J.A., Belis, J. A. armd Lloyd, J. W. : Androgen

assimilation by the epithelium and muscle

of the guinea-pig seminal vesicle, 324

Mazze, H. I., see Barr, G. A., 257

McAfee, 1). A., see Kalix, P., 676

McMillan, D. E., see Leander, J. I)., 724McNeill, J. H. and Verma, S. C. : Blockade by

burinmamide of the effects of histamine and

hist amine analogs on cardiac contractility,

phosphorylase activation and cyclic adeno-

sine monophosphate, 180

Mecanmylamine , effect s on t hermoregulat.ion

against body cooling in conscious rabbit, 400

Melanin, relationship to mydriatic effect of (-)-

‘4C-ephedrine, 342

Mendez, IL, Pastelin, (.1. and Kabela, E. : Theinfluence of the position of attachment ofthe lactoime ring to the steroid nucleus on theaction of cardiac glycosides, 189

Merrinman, C. H., Upchurch, H. F. andKanmpschmidt, H. F. : Prostaglandin E,,

aspirin and the action of leukocytic endog-

enous nmediator, 516

Mescaline , act ion on 5-hydroxytryptamine re-

ceptors in umbilical vasculature, 336

Met abolisniandrogelm, liver microsornal, increased by pheno-

barbit al, correlation with decreased andro-

germ action on rat senmitmal vesicles, 287internmediary, in rats, effects of giucocorticoids,

310of diazoxide in nmarm and experimeimtai anmmals,

248of digoxin in acutely hypokalenmic and nornmo-

kaleimmic dogs, effect of insulin and glucoseorm, 564

ofenflurane inFischer344 rats, conmparisoim with

met imoxvflurane , 257

d)f hexobarbit al iii rat , 15

1974 INDEX 749

of levo-nmethadone-1-’H in dog, 34

of N , N’-di-methoxyniethyi-phenobarbital inrat, 8

of imorepirmephrine in isolated, perfused spleenand heart, effect of methyiguanidine, 93

of testosterotme by guinea-pig seminal vesicle,

324release and, of ‘H-norepinephrine, relationship

with alpha receptor block and inhibition of

norepinephrine uptake, 368

Metaboiite, glycol, of propranolol [3-(a-imaph-t hoxv) -1 , 2-propanediol] , cent ral nervous

svstenm effects and metabolic disposition of,

86

Methadone, effect on uptake and release of neuro-

transmitters in isolated synaptosomes, 419levo-Methadone-1 -‘H, physiological dispositioim

and biotransformation in dog, 34Methemoglobin-induced hypoxia, role in pot.eimtia-

tion of barbiturate action by sodiunm nitrite

in mouse, 481Methicillin, kiimetic studies, 491

Methoxyflurane, renal effects and nmetaboiism inFiscimer 344 rats, conmparison with enflurane,

257

N -Met hoxynmet hylphenobarbit ai , as prinmary

metabolite of N , N’-di-nmet hoxynmethyl-phenobarbital in rat , 8

N , N ‘-l)i-nmet hoxymet hyl-phenobarbital, nmeta-bolic fate in rat, 8

Methylguanidine, effect on norepinephriime nmetab-oiisnm itm isolated, perfused spleen and heart,

93

Methyipimenidate, effects on repeated acquisitionof behavioral chains, 700

Met hysergide , effect on Schistosoma uuua uuson i, 529Mice

C57BL and BALB, differential effects of etimaimol

aimd petmtobarbitai mm sleep tinme in, 27central imervous system effects and nmetabolic

disposition of glycol nmetabolite of pro-

prarmolol in, 86

potentiation of barbiturate action by sodiumhit rite irm, role of nmethenmoglobirm-inducedhypoxia, 481

��hole body , nut oradiographic dist ribut ion of

‘4C-hemicholinium-3 in, 77Microcirculat ory systems, cardiovascular and sub-

cutatmeous, in bat, influence of �1’-tetrahv-

drocaimnabinol, 624Miller, F. N., see Brown, 1). J., 624

Misra, A. I.�.,Bioch, H., Vadianmani, N. L. andMule, s. J. : Physiological disposition andi)iOt raimsformatioim of bevo-nmet hadone-l -‘H

in the dog, 34

MJ 1999, effect mm cyclic adenosine nmonophosphatein rabbit superior cervical ganglioim, 676

Monkey, metabolisnm of diazoxide in, 248

Morphine

biliarv excretion, effects of novobiocin, 504effect on uptake and release of neurotransmit-

ters in isolated synaptosonmes, 419

Morphine-3-glucuroimide , biiiary excretion , effectsof novobiocirm, 504

Mosimann, W., see Cubeddu, L., X., 93Mule, S. J., see Misra, A. L., 34

Murthy, H. V., Kidwai, A. M. and Daniel, F�. E.:Dissociation of contractile effect and

binding and inhibition of Na�-K�-adenosine

triphosphatase by cardiac giycosides in

rabbit myometrium, 575Murthy, II. V., Kidwai, A. M. and I)aniel, E. E.:

Subcellular distribution of cardiac glyco-

sides in rabbit and rat myometriurn and

their binding to isolated plasma membrane,

582

Musclepotassium exchange in, blockade by SKF 525-A

compared with butacaine, 553

skeletal, frog, effect of hypertonic solutions and“glycerol treatment” on calcium and mag-

nesium movements of, 536skeletal, in acutely hypokalemic and nornmo-

kalemic dogs, uptake of digoxin in, effect of

insulin and glucose, 564

smooth, vascular, effects of neomycin on 45Ca

movements armd contractile responses in, 472ventricular, cat, direct and indirect effects of

nicotine on, 148

ventricular, cat, effect of nicotine on action

potential of, 157Myers, M. G., see Reid, J. L., 394Myomet rium

rabbit and rat, binding of cardiac glycosides iim,

582

rabbit, dissociation of contractile effect. andbinding and inhibition of Na�-K4-adenosine

triphosphatase by cardiac glycosides in, 575

Narahashi, T., see Shapiro, B. I., 66

Narcotic analgesic drugs, effect on uptake andrelease of imeurotransmitters iim isolated

synaptosomes, 419Needlenman, P., Douglas, J. H., Jr., Jakschik, B.,

Stoeckiein, P. B. and Johnson, E. M., Jr.:Release of renal prostaglandin by catechola-nmines: Relationship to renal endocrine

function, 453

Neff, N. H., see Sanipath, S. S., 410

Nelson, L. D., see Schmid, P. G., 124

Neomycin

aimd l)elmicillin-treated rats, drug absorption in,

277

effects on 45Ca movements and contractile

responses in vascular smooth muscle, 472Nerve, sympathetic (see Sympathetic nerve)

Oesch, F. : Trans-synaptic induction of choline

750 INDEX Vol. 188

Nervous systenm

central (see Central nervous systenm)synmpathetic (see Sympathetic nervous system)

Neuromuscular transmission, irm rat, effects ofdibutyryl cyclic adenosine 3’ , 5’-moimophos-phate, theophylline and aminophylline, 447

Neurons, serotonergic, comparison of effects of

LSl) and serotonin on, 688

Nichols, D. E., see Cheng, H. C., 114

Nicotinedirect and indirect effects on cat ventricular

muscle, 148effect on action potential of cat ventricle, 157

Nictitating nmembrane

cat., release of norepinephrine by phenylephrinein, 640

pithed cat, seimsitivity to l-norepineplmrine after

denervation or decent ralization , 630

Nilsson, K., see Bassett., A. L., 148

Norepinephrinecontent of guinea-pig atria, effect of reserpiime,

654

effect of quinidine on vasoconstrictor responses

to, 124

-induced changes in heart rate, antagonized by

propranolol, 198-induced contractile responses in rabbit aorta,

effects of neomycin, 472

-induced release of renal prostagiandirm, relationto renal function, 453

interaction with prostaglandin E� in cat heart.,

135

metabolism in isolated, perfused spleen andheart, effect. of methylguanidine, 93

removal from pulmonary circulation, effect ofdrugs, 386

store, reserpine-resistant, in adrenergic nerve

terminals of guinea-pig atria, 668

store, reserpine-induced depletiorm in, as criterionfor mechanism of action of sympatho-

mimetic amines, 640

‘4C.Norepinephrine, uptake and release in isolatedsynaptosomes, effect. of narcotic analgesic

drugs, 419

3H-Norepinephrine , release and nmet abolism,relationship wit.h alpha receptor block and

inhibition of norepinephrine uptake, 368l-Norepinephrine, sensit ivity of cat nictitating

menmbrane after denervation or decentrali-

zation to, 630Normetanephrine, effect. on removal of norepi-

nephrine and 5-hydroxyt rypt ami ne fromrabbit lung, 386

Novobiocin, effects on biiiary excretion of nmor-

phine, morphine-3-glucuronide armd other

compounds, 504

acetylt raimsferase in the preganglionicneuron of the peripheral sympathetic

imervous system, 439Olsen, N. J., see Hillman, G. IL, 529Ouabain

binding in rabbit and rat myonmetrium, 582cardiac effects in depolarized guinea-pig atria,

166

diimvdro-ouabain and, actions in dog heart.

compared with senmisynt.hetic cardiac giy-

cosides, 189

effects of novobiocin on biliarv excretion of, 504inhibition and binding of Na�-K�-adenosine

triphosphatase in rabbit myornetrium by,

dissociation from contractile effect, 575renal and gastrointestinal excretion in maim and

dog, 615Oxprenoloi, effects on plasma ream activity in

rabbit, 234

Park, J. P., Felsenfeid, A. J., Sands., M. P. and

(luntheroth, W. G. : Indirect alpha adre-imergic response to isoproterermol in the dog

spleen, 353Pastelin, C)., see Mendez, II., 189

Patel, C;., see Baumel, T. P., 481

Patil, P. N., Shimada, K., Feller, D. H. andMalspeis, L. : Accumulation of (-)-‘4C-ephedrine by the pigmented and the nonpig-mented iris, 342

Penicillenic acids of methicillin and phenoxy-

methylpenicillin, kinetic studies, 491

Penicillinand neonmycin-treat.ed rats, drug absorption in,

277

effects of salicylate and probeimecid on cerebro-

spinal fluid transport of, 55hypersensitivity, studies of potential relevance

to, 491

Pent obarbit alconmparisons wit h d-amphet.anmine and chlor-

promazine on multiple and mixed schedules,724

ethanol and, differential effects of sleep time inC57BL and BALB mice, 27

Pettinger, W. A., see Tanaka, K., 229

Phenobarbitaieffects on repeated acquisition of behavioral

chains, 700increased liver microsomal androgen metabolism

by, correlation with decreased androgen

action on rat seminal vesicles, 287Phenoxybenzanmine

effect on alpha receptors and uptake armd releaseof norepinephrine in cat spleen, 368

effect on contractions induced in sheep umbilical

arteries by LSD, nmescaline and bufotenine,336

1974 INDEX 751

inhibition of adrenergic vasoconstriction by, 124

effect on cyclic adenosine nmormophosphate inrabbit superior cervical gangliorm, 676

effect on renmoval of norepinephrine and 5-hydroxytryptamine from rabbit lung, 386

Phenoxynmethylpeimicillin , kinetic studies, 491

Phentolamine

effect on alpha receptors and uptake aimd release

of norepiimephrine in cat spleen, 368effect on cyclic adenosine monophosphate iim

rabbit superior cervical ganglion, 676

effect. orm removal of norepinephrine and 5-hy-droxytryptanmine fronm rabbit. lung, 386

Phenylephrine, release of imorepiimephrine from

guinea-pig atria and cat nictitating nmenm-

brane by, 640

Phosphorus, serunm, in rabbits, effect of synthetic

salmon calcitonin, 318

Phosphorylase activation, blockade by burim-

amide of effects of histamine and analogs

on, 180

Physical stress, effects on disposition of drugs

eliminated by liver in man, 1

Pigeonscomparisons of (l-amphet amine , pent obarbit al

and chiorpronmazine on multiple and mixed

schedules in, 724

repeated acquisition of behavioral chains under

chronic drug conditions in, 700

Pinto, G. T., see Freire-Maia, L., 207

Pitternman, A., see Baumel, I. P., 481

Placidi, Cl-F., see Domino, E. F., 77

Plasmadog, levels of levo-methadone-l-’H itm, 34renin activity irm conscious rabbit, effects of beta

adrenergic blocking agents, 234

Platelet, aggregation, caused by thrombin and

protanmine, inhibitory effect of polyphlor-etin phosphate, 214

Polychlorinated biphenyls, inducibility of cu-taneous and hepatic drug metabolizing

enzynmes and cytochrome P450 by, 300

Polyphloretin phosphate, inhibitory effect. onplatelet aggregation and henmodynamic and

respiratory changes caused by thrombinand protanmine, 214

Potassium

exchange in nmuscle, blockade by SKF 525-Acompared with butacaine, 553

excretion in dog, effect of acute and chronicalcohol administration, 461

-induced contractile responses in rabbit. aorta,effects of imeomycin, 472

serum, in rabbits, effects of synthetic salmoncalcitonin, 318

Powell, B. J., see Hill, S. Y., 415

Pract.oloi, effect on isoproterenol-induced re-sponses in anesthetized dog, 357

Pregarmglionic neuron of peripheral sympathetic

nervous system , t raims-synapt ic inductionof choline acetvltransferase in, 439

Pregnenolone -16a-carbonit rile , pharmacodynamicinteractions with various drugs, 45

Preston, E. : Central effects of cholinergic-receptor

blocking drugs on the conscious rabbit’s

thermoregulation against body cooling, 400Prindoiol, effects on plasnma renin activity in

rabbit, 234

Privitera, P. J., see Saelens, D. A., 86Probenecid

effect on cerebrospinal fluid transport of peni-cillin, aminosalicylic acid and iodide, 55

effect. on uptake of 5-hydroxyindoleacetic acidby rat choroid plexus, 410

ability to antagonize induced changes in heart

rate, 198and glycol met.abolite [3-(a-naphthoxy-1 , 2-

propanediol], central nervous system effects

and nmetabolic disposition, 86effect on isoproterenol-induced responses in

anesthetized dog, 357effect on ketamine-induced renin release in rat,

229

effect. on plasma ream activity in rabbit, 234effect on removal of norepinephrine and 5-hy-

droxytryptamine from rabbit. lung, 386

-treated cat ventricular muscles, effect of nico-tine on action potential of, 157

-treated cat ventricular muscle, inotropic effects

of nicotine, 148d-, 1- and dl-Propranolol, intracerebroventricular,

cardiovascular effects in conscious rabbit,

394

Prost aglandininhibition of metabolically induced coronary

vasodilation, 135E1, and action of leukocytic endogenous media-

tor, 516renal, released by catecholamines, relation to

renal endocrine function, 453

Protamine, inhibitory effect of polyphioretin phos-

phate on platelet. aggregation and hemo-dynamic and respiratory changes caused by,

214

Pruitt, A. W., Faraj, B. A. and Dayton, P. G.:

Metabolism of diazoxide in man and experi-mental animals, 248

Psychotomimetics (see also specific drug) , effectson vascular strips, 114

Purkinje fibers, sheep, electrophysiological effectsof dopamine on, 596

Quinidinecardiac effects in depolarized guinea-pig atria,

166

752 INDEX Vol. 188

Rabbitaorta, influence of sarcosine substituted in

position 1 on potency of angioteimsin analogs

in, 222conscious, cardiovascular effects of izmt racere-

brovent ricular (1-, 1- and (lb-propranolol in,

394conscious, ceimtral effects d)f cholinergic receptor

blocking drugs Ofl thernmoregulation against.body cooliimg in, 400

conscious, effects d)f beta adrenergic blockingagents on piasnma renin activity in, 234

effect of neomvcin on 45Ca immovements andcont met ile responses in vascular smoothmuscle of, 472

effect of salicylate and probetmecid on cerei)ro-spinal fluid transport of penicillin, amitmo-

saiicviic acid and iodide in, 55

effect of synthetic sainmon caicitonin on glimcose,

blood urea nitrogeim and serunm electrolytesin, 318

lung, effect of drugs oim renmovai c)f norepineph-

rine and 5-hydroxytryptanmine fronm, 386metaboiisnm of diazoxide in, 248

immyometriunm, i)inding of cardiac glvcosides to,

582

myonmet riuni , dissociat ion of cont met ile effectand biiidiiig and inhibition of Na�-K�-

adermosine t riphosphat ase by cardiac giv -cosides in, 575

release of renal prost aglaimdi ii by cat echolaimmines,

relation to renal endocrine functioim in, 453superior cervical ganglion , syiiapt icaliy nme-

diated increase irm cyclic adenosine immono-

phosphate in, 676

Raiteri, M., see Levi, G., 429Randall, C. L. and Lester, 1). : 1)ifferential effects

of ethanol and pentobarbital on sleep tinmeiim C57BL and BALB mice, 27

Rat(s)aorta, influence of sarcosirme substituted in

position 1 on potency of angiotensin analogs

in, 222brain synaptosomes, effect of narcotic anal-

gesic drugs on uptake and release of imeuro-transmitters ‘II, 419

brain synaptosomes, uptake of ‘H--y-anm�no-hutyric acid and ‘4C-glutamate, regiormal

differences and possible role of exchaimgeprocesses, 429

cardiovascular effects produced by purifiedscorpion toxin in, 207

choroid plexus, acid transport systenm in, 410comparison of effects of LSD and serotonirm on

serotonergic neurt�ns in, 688cutaneous and hepatic drug nmetaboiizing en-

zymes and cytochronme P-450 induction bypolychiorinated biphenyis and 1)l)T, 300

dist ribut ion , eliminat ion aimd anticoagulantaction of dicumarol iim, 293

effect of dibutyryi cyclic adenosirme 3’,5’-immono-

j)h0sphIlte , theophylline and anminophyllineon, 447

effect of novobiocin during biliarv excretion of

nmorphine , rmiorpimiime-3-glucuroimide andotimer compounds in, 504

Fischer 344, comparisoim of renal effects and

immetalmoiism of enflurane and nmet hoxyflurane

in, 257

giucocorticoid administration to, effects on iii

vitro intermediary nmetabolisnm, 310kidney cortex, effect. of halogenated hydrocar-

1)01) iimsecticides on cyclic adenosiime 3’S’-nmonophosphate-’H format iotm by, 265

nietabolic fate of hexobarhital jim, 15

nmetaboiic fate of N , N’-di-nmethoxvnmethyl-

phenobarbital jim, S

Immetai)olism of diazoxide iii, 248

immyonmetriunm, i)inding of cardiac glvcosides to,

582

pharnmacodynanmic iimteract ions among gluco-,nmiime mb- and ghiconmi imeralocort icoids,

pregimenolone -16a-carbon it rile and various

drugs in, 45

pretreated with antibiotics, drug absorption in,

277

prost aglandin E � , aspirin aimd act ion of icuko-cvtic eimdogenous mediator iim, 516

renum release and ketanmiime-iimduced cardio-

vascular st imitlat ion in , 229

seimminai vesicles, correlatioim of iimcreased liver

nu crosonmal androgeim immetaholisnm by 1)heno-

harhit al wit h decreased androgeim act ion on,

287

S1)atial and paw preferences in, relatioimship to

rate-dependent effects of (/-anmphet anmine,

714

t raims-synapt ic iimduct ion of choline Icetyl-

t ransferase in pregaimglionic neuron of

peripimeral sympat het ic imervous systenm of,

439

unanest hetized, ant idiuret ic act ion of 1-

(leanmino-[8-D-argininel-vasopressin in , 241

Reid, J. 1.�., Lewis, P. J., Myers, 1�vI. G. aimd 1)ollery,

C. T. : Cardiovascular effects of intracere-

brovermtricular d-, 1- and (bl-propranoloi iim

the conscious rabbit, 394

Beimal effects of enflurane irm Fiscimer 344 rats,

conmparison with methoxvfluraime, 257

Renal function

effect of acute aimd cimronic alcohol adimministra-

tioii oil, 461

rel:mt ioim t 0 catechoianmine-iimducecl release of

prostaglandin, 453

1974 INDEX 753

cat , relatioimships between alpha receptor block,inhibitiorm of norepinephrine uptake and

Renin

activity, plasma, in conscious rabbit, effects ofbeta adrenergic blocking agents, 234

release, ket anmine-induced cardiovascular stinm-

ulatiorm and, in rat., 229

Repeated acquisition of behavioral chains, chroniceffects of drugs on, 700

Reserpirme

effects on adrenergic nerve function, 654-iimduced depletion of norepinephrine stores aS

criterion for mechaimism of action of svm-

pathonmimetic amines, 640

-resistant norepinephrine store in adreimergicnerve terminals in guinea-pig atria, 668

-treated cat ventricular nmuscle, effects of imico-

tine, 148

-treated rats, trans-synaptic iimduction ofcholine acetyltransferase in, 439

-treated vermtricuiar nmuscles, effect of nicotine

01) actiorm potential of, 157

Respiratory changes caused by throimmbin and

prot anmine , iimhibit c�ry effect of pd)iy-

phloretin phosphate, 214

Saeleims, D. A., Waile, T., Privitera, P. J., Kimapp,

1). II. and (1affney, T. : Cermtrai imervous

system effects and metabolic disposition of a

glycol inet.abolite of propranolol, 86

Salicylate, effects on cerebrospirmal fluid transport.of penicillin, aminosalicylic acid aimd iodide,

55Sampath, S. S. and Neff, N. H. : The eiizmminatioim

of 5-hydroxyindoleacet ic acid fronm cerebro-

spinal fluid: Characteristics of the acid

trarmsport system of the choroid plexus, 410Sands, M. P., see Park, J. P., 353

[1-Sarcosinelaimgiotensin and analogs, poteimcy, 222Sargent, W. Q., Simpson, J. H. and Beard, J. 1).:

The effect of aci.ite and chronic alcoholadnmirmistration on reimal heinodynanmics and

monovalent ion excretion , 461Schaefer, J.-M., see Van Orden, L. S., III, 654

Schistosoma niauisoni, effect of methysergide anddihydroergotamirme, 529

Schmid, P. U., Nelson, L. 1)., Mark, A. L., HeistadD. 1). aimd Abboud, F. M. : Inhibition of

adrenergic vasoconstriction by quinidine,

124Schorderet , M., see Kalix, P., 676Schwartz, A., see Martinez-Maidonado, M., 605

Schwartz, F. L., see Mawhinney, M. G., 324Schwin, H., see Hill, S. Y., 415

Scorpion toxin, purified, cardiovascular effects in

rat, 207

Selden, H, Margolies, M. N. aimd Smith, T. W.:Henai and gastrointestinal excretion ofouabain in dog aimd maim, 615

Selye, H., see Szabo, S., 45

Seminal vesicie(s)

guinea-pig, androgen assimilation by epithelium

and muscle of, 324rat., correlation of increased liver microsomal

androgen immetabolism by phenobarbital

with decreased androgen action on, 287

Senft, A. W., see Hillman, G. R., 529

Serotonin (see also 5-1-lydroxytrypt amine)

effects on serot onergic neurons , comparisonwith LSD, 688

-induced contractile responses in rabbit aorta,

effects of imeomycin, 472

Shapiro, B. I., Wang, C. M. and Narahashi, T.:Effects of st.rychniime on ionic conductances

of squid axon immembrane, 66

Sheep

cardiac Purki nj e fibers , elect rophvsiological

effects of dopanmine on, 596umbilical arteries, action of LSD, mescaline and

bufot en i ime d)im 5-hydroxyt rypt anmine re-ceptors in, 336

Shimada, K., see Patil, P. N., 342

Sidell, F. IL, see Swartz, H. 1)., 1

Simpson, J. IL, see Sargent, W. Q., 461

Singhal, H. L. , see Kacew, S. , 265

Skeletal nmuscle (see Muscle, skeletal)

SKF 525-A (�-diethylamiimoethyl diphenyipropyl-

acetate), blockade of potassium exchange inmuscle by, conmparisoim with butacaine, 553

Skin, rat, enzynme armd cytochroine P-450 irmduction

by polychiorinat.ed biphenyls and Dl)T, 300

Sleep time in C57BL and BALB mice, differentialeffects of ethanol aimd pentobarbital on, 27

Smith, C. B.

see Aimtonaccio, M. J., 668see Van Orden, L. S., III, 654

Smith, 1). and Fujimoto, J. M. : Alterations

produced by novobiocin during biliaryexcret ioim of morphine , morphi ne -3-gui-curonide and other compounds, 504

Smith, T. W., see Seldeim, IL, 615

Smooth muscle (see Muscle, smooth)

Sodium

excretion iim dog, effect of acute arid chronicalcohol adnministration, 461

serum, in rabbits, effect of synthetic serumcalcitonin, 318

Sodiunm imit rite , potentiation of barhit orate actionin nmouse by, role of methemoglobirm-inducedhypoxia, 481

Spector, H. and Lorenzo, A. V. : The effects of

Spleen

salicylate and probenecid on the cerebro-spinal fluid transport of peniciliin, anmino-

salicylic acid and iodide, 55

754 INI)EX Vol. 188

Talesnik, J., see Sunahara, F. A., 135

release and metabolism of ‘H-norepineph-

rine in, 368dog, indirect alpha adrenergic response to

isoproterenol in, 353dog, levels of levo-methadone-1-’lI in, 34i8Olated, perfused, effect of nmethylguaimidine on

norepinephrine metabolism in, 93Squid, axon membrane, effects of strychnine on

ionic conductances of, 66

Steroid(s)and drug interactions, 310

metabolic effects, 310nucleus, position of att.achnment of lactone rirmg

to as influence on actioim of cardiac gly-

cosides, 189Stoecklein, P. B., see Needleman, P., 453

Stokes, G. S., see Weber, M. A., 234Strychnine, effects on ionic conductances of squid

axon membrane, 66Sulfobromophthalein, effects of novobiocin on

biliary excretion of, 504Sunahara, F. A. and Talesnik, J. : Prostaglaimdin

inhibition of metabolically induced

coronary vasodilation, 135Supersensitivity of cat nictitating membrane to

l-norepinephrine, 630Swartz, H. 1)., Sidell, F. H., and Cucinell, S. A.:

Effects of physical stress on the disposition

of drugs eliminated by the liver in maim, 1

Swedenborg, J. : Inhibitory effects of polyphioretinphosphate upon platelet aggregation and

hemodynamic and respirat ory changescaused by thrombin and protamine, 214

Sympat het ic nerve, activity , after decarboxylase

inhibition in cat, effect of L-dOpa, 107Sympat hetic nervous system

dog, effects of psychotomimetic amphetamines,114

peripheral, trans-synapt ic induct ion of cholineacetyltransferase in preganglionic neuron of,439

Synapt osomesisolated, effect of narcotic analgesic drugs on

uptake and release of neurotransmitters in,419

regional differences in uptake of ‘H--y-amino-

butyric acid and ‘4C-glutamate, possiblerole of exchange processes, 429

Sympathomimetic amines, mechanism of action,

reserpine-induced depletion of norepineph-rine stores as criterion of, 640

Szabo, S., Kourounakis, P., Selye, H. and 1)aSilva, 0. : Pharmacodynamic interactions

among gluco-, mineralo- and glucomineraio-corticoids, pregnenolone-lGa-carbonitrile

and various drugs, 45

Tanaka, K. aimd Pettiimger, W. A. : lleniim releaseand ketanmine-induced cardiovascular stim-

ulation in the rat, 229Testosterone

effect on growth of semiimai vesicles in pheno-barbital-pretreated rats, 287

metabolism by guinea-pig seminal vesicie, 324Tetracyciirme, absorption iim rats treated with

antibiotics, 277

�1 9-Tet rahydrocan nabinoi , ii fi iience on cardio-

vascular and subcut aimeous nmicrocircula-tory svstenms in hat, 624

Theophylline , effects on neuroimmuscular t rans-

mission in rat, 447

Thermoregulation against body cooling in con-scious rabbit, effects of choiinergic receptor

blocking drugs, 400

Thomas, J. A., see Mawhinnev, M. (., 324

Thompson, 1). M. : Repeated acquisition of be-havioral chains tinder chronic drug coiidi-

tions, 700

Thorneil, I. IL, see Weber, M. A., 234

Thronmbin , inhibitory effect of polyphloretinphosphate on platelet aggregation and

henmodvnamic and respi rat ory changes

caused by, 214

Thynmoxamine, effect on cyclic adenosine nmono-

phosphate in rabbit superior cervical gan-

giion, 676

Thyrunm, P. T. : Inotropic stimuli and systolic

traimsmeimmbrane calciunm flow iii depolarized

guinea-pig atrium, 166

Tissues (see also specific nanme)

dog, levels of le,’o-methadone-l-’H irm, 34guinea-pig, assimiiatioim of testosterone by, 324mouse , autoradiographic dist ri but ioim of 14C_

hemicholinium-3 in, 77

Trans-synapt ic induct ion of choline acetylt miss-

ferase in preganglionic imeuron of peripheralsynmpathetic nervous systenm, 439

Triamcinoioime, iimteract iorms with various drugs, 45

1 , 1 , 1 - Trichloro - 2 , 2 - bis ( p -chioropheimyl ) et.hane(see 1)I)T)

Tsai, T. H. and Kuhn, W. L. : Sensitivity of thenictitating membrane of the pithed cat toinfusions of l-norepinephrine after deimerva-tion or decentralization, 630

Tsaparas, N., see Martinez-Maldonado, M., 605

d-Tubocuramine, effects of novobiocin on biiiary

excretion of, 504

Tyramine, responses of guinea-pig atria to, effect

of resempine, 654

TJpchurch, C. it, see Merminman, C. R., 516

Urine

man and dog, excretion of ouahain in, 615

rat, met.abolites of hexobarbital in, 15

1974 INDEX 755

Walle, T., see Saelens, D. A., 86

Vadlanmani, N. L., see Misra, A. L., 34

Vanillyimandelic acid, effect on uptake of 5-hydroxyindoleacetic acid by rat choroid

plexus, 410

Van Orden, L. S., III, Schaefer, J.-M., Aimtonac-cio, M. J. and Smith, C. B. : Fine structuralidentification of a reserpine-resistant nor-epinephrine store in adrenergic nerveterminals in guinea-pig atria, 654

Vascular responses to quinidine in dog and man,124

Vasopressin analog (1 -deamino-[8-D-arginine}-vasopressin), antidiuretic action in rats, 241

V#{225}vra,I.,Machov#{225}, A. and Krej�i, I. : Antidiuretic

action of 1 -deamino-[8-D-argininej-vaso-pressin in unanesthetized rats, 241

Ventricle

cat., direct and indirect inotropic effects ofnicotine on , 148

cat, effect of nicotine on action potential of, 157

Verapamil, cardiac effects in depolarized guinea-pig atria, 166

Verma, S. C., see McNeill, J. H., 180

Voile, H. L., see Henderson, E. (4., 553

Walsh, C. T. and Levine, R. II. : Drug absorptionin rats pretreated with antibiotics, 277

Wang, C. M., see Shapiro, B. I., 66

Wasserman, M. A. and Levy, B. : Selective beta

adrenergic receptor antagonism in theanesthetized dog, 357

Watanabe, A. M., Judy, W. V. and Cardon, P. V.:Effect of L-dOpa on blood pressure and

sympathetic nerve activity after decar-boxylase inhibition in cats, 107

Waud, D. R. : Adsorption isotherm vs. ion-ex-

change models for the drug-receptor reac-

tion, 520

Weber, M. A., Thornell, I. II. and Stokes, G. S.:Effects of beta adrenergic blocking agents

on plasma renin activity in the conscious

rabbit, 234Welch, R. M., see Levin, W., 287

Weiner, N., see Cubeddu, L., X., 93, 368

Weiss, G. B., see Goodman, F. R., 472Wiggins, J. R., see Bassett, A. L., 148Williams, N., see Clouet, D. H., 419Wilson, D. F. : The effects of dibut.yryl cyclic

adenosine 3’ , 5’-monophosphate , theophyl-

line and aminophylline on neuromusculartransmission in the rat, 447