Henochscholen
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Henoch-Schönlein purpura Henoch-Schönlein purpura (HSP) is an inflammatory disorder characterized by a generalized vasculitis involving the small vessels of the skin, GI tract, kidneys, joints, and, rarely, the lungs and CNS. It is the most common vasculitis in children. Pathophysiology It is thought to be multifactorial with genetic, environmental, and antigenic components. 75% of patients report antecedent upper-respiratory, pharyngeal, or GI infections Multiple bacterial and viral infectious agents drug ingestions and vaccinations. thought to be an immunoglobulin A (IgA)–mediated autoimmune phenomenon. Symptoms Abdominal pain Joint pain Purple spots on the skin (purpura), usually over the buttocks, lower legs, and elbows Bloody stools Hives or angioedema Nausea Diarrhea Painful menstruation Vomiting
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Henoch-Schönlein purpura
Henoch-Schönlein purpura (HSP) is an inflammatory disorder characterized by a generalized vasculitis involving the small vessels of the skin, GI tract, kidneys, joints, and, rarely, the lungs and CNS. It is the most common vasculitis in children.
Pathophysiology
It is thought to be multifactorial with genetic, environmental, and antigenic components. 75% of patients report antecedent upper-respiratory, pharyngeal, or GI infections Multiple bacterial and viral infectious agents drug ingestions and vaccinations. thought to be an immunoglobulin A (IgA)–mediated autoimmune phenomenon.
Symptoms Abdominal pain Joint pain Purple spots on the skin (purpura), usually over the buttocks, lower
legs, and elbows Bloody stools Hives or angioedema
Nausea
Diarrhea
Painful menstruation
Vomiting
